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Wyszukujesz frazę ""Amyloid"" wg kryterium: Temat


Tytuł :
31-35 Decreases Neprilysin-Mediated Alzheimer's Amyloid-β Peptide Degradation.
Autorzy :
Leite JP; i3S-Instituto de Investigação e Inovação em Saúde, Rua Alfredo Allen, 208, Porto 4200-135, Portugal.; IBMC-Instituto de Biologia Molecular e Celular, Universidade do Porto, Rua Alfredo Allen, 208, Porto 4200-135, Portugal.; Programa Doutoral em Biologia Molecular e Celular (MCbiology), ICBAS-Instituto de Ciências Biomédicas Abel Salazar, Rua de Jorge Viterbo Ferreira 228, Porto 4050-313, Portugal.; ICBAS-Instituto de Ciências Biomédicas Abel Salazar, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal.
Lete MG; CIC bioGUNE, Bizkaia Technology Park, Building 801A, Derio 48170, Spain.
Fowler SB; Antibody Discovery & Protein Engineering R&D, AstraZeneca, Cambridge CB21 6GH, U.K.
Gimeno A; CIC bioGUNE, Bizkaia Technology Park, Building 801A, Derio 48170, Spain.
Rocha JF; UCIBIO/REQUIMTE, BioSIM-Department of Biomedicine, Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, Porto 4200-319, Portugal.
Sousa SF; UCIBIO/REQUIMTE, BioSIM-Department of Biomedicine, Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, Porto 4200-319, Portugal.
Webster CI; Antibody Discovery & Protein Engineering R&D, AstraZeneca, Cambridge CB21 6GH, U.K.
Jiménez-Bar Bero JJ; CIC bioGUNE, Bizkaia Technology Park, Building 801A, Derio 48170, Spain.; Ikerbasque, Basque Foundation for Science, Bilbao 48013, Spain.; Department of Organic Chemistry II, Faculty of Science and Technology, UPV-EHU, 48940 Leioa, Spain.
Gales L; i3S-Instituto de Investigação e Inovação em Saúde, Rua Alfredo Allen, 208, Porto 4200-135, Portugal.; IBMC-Instituto de Biologia Molecular e Celular, Universidade do Porto, Rua Alfredo Allen, 208, Porto 4200-135, Portugal.; ICBAS-Instituto de Ciências Biomédicas Abel Salazar, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal.
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Źródło :
ACS chemical neuroscience [ACS Chem Neurosci] 2021 Oct 06; Vol. 12 (19), pp. 3708-3718. Date of Electronic Publication: 2021 Sep 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alzheimer Disease*
Amyloid beta-Peptides*
Amyloid ; Humans ; Neprilysin ; Plaque, Amyloid
Czasopismo naukowe
Tytuł :
Effect of involuntary chronic physical exercise on beta-amyloid protein in experimental models of Alzheimer's disease: Systematic review and meta-analysis.
Autorzy :
Vasconcelos-Filho FSL; Pró-reitoria de Cultura, Universidade Federal do Cariri, Juazeiro do Norte, Ceará, Brazil; Laboratório de Bioquímica e Expressão Gênica, Instituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, Fortaleza, Ceará, Brazil. Electronic address: .
da Rocha Oliveira LC; Departamento de Ciências da Saúde, Faculdade de Medicina, Universidade Federal Rural do Semi-árido, Mossoró, Rio Grande do Norte, Brazil.
de Freitas TBC; Departamento de Ciências da Saúde, Faculdade de Medicina, Universidade Federal Rural do Semi-árido, Mossoró, Rio Grande do Norte, Brazil.
de Pontes PADS; Departamento de Ciências da Saúde, Faculdade de Medicina, Universidade Federal Rural do Semi-árido, Mossoró, Rio Grande do Norte, Brazil.
Rocha-E-Silva RCD; Faculdade de Medicina Veterinária, Centro Universitário de Juazeiro do Norte, Juazeiro do Norte, Ceará, Brazil.
Godinho WDN; Laboratório de Bioquímica e Expressão Gênica, Instituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, Fortaleza, Ceará, Brazil.
Chaves EMC; Instituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, Fortaleza, Ceará, Brazil.
da Silva CGL; Faculdade de Medicina, Universidade Federal do Cariri, Juazeiro do Norte, Ceará, Brazil.
Soares PM; Laboratório de Bioquímica e Expressão Gênica, Instituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, Fortaleza, Ceará, Brazil.
Ceccatto VM; Laboratório de Bioquímica e Expressão Gênica, Instituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, Fortaleza, Ceará, Brazil.
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Źródło :
Experimental gerontology [Exp Gerontol] 2021 Oct 01; Vol. 153, pp. 111502. Date of Electronic Publication: 2021 Jul 31.
Typ publikacji :
Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Review; Systematic Review
MeSH Terms :
Alzheimer Disease*/therapy
Amyloid beta-Peptides*
Amyloid beta-Protein Precursor ; Animals ; Disease Models, Animal ; Exercise ; Female ; Mice ; Mice, Transgenic ; Models, Theoretical ; Plaque, Amyloid
Czasopismo naukowe
Tytuł :
Age-related amyloidosis outside the brain: A state-of-the-art review.
Autorzy :
Tasaki M; Department of Morphological and Physiological Sciences, Graduate School of Health Sciences, Kumamoto University, Kumamoto, Japan.
Lavatelli F; Amyloidosis Research and Treatment Center, Fondazione IRCCS Policlinico San Matteo and University of Pavia, Pavia, Italy. Electronic address: .
Obici L; Amyloidosis Research and Treatment Center, Fondazione IRCCS Policlinico San Matteo and University of Pavia, Pavia, Italy.
Obayashi K; Department of Morphological and Physiological Sciences, Graduate School of Health Sciences, Kumamoto University, Kumamoto, Japan.
Miyamoto T; Department of Orthopedic Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Merlini G; Amyloidosis Research and Treatment Center, Fondazione IRCCS Policlinico San Matteo and University of Pavia, Pavia, Italy.
Palladini G; Amyloidosis Research and Treatment Center, Fondazione IRCCS Policlinico San Matteo and University of Pavia, Pavia, Italy.
Ando Y; Department of Amyloidosis Research, Nagasaki International University, Sasebo, Japan.
Ueda M; Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan. Electronic address: .
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Źródło :
Ageing research reviews [Ageing Res Rev] 2021 Sep; Vol. 70, pp. 101388. Date of Electronic Publication: 2021 Jun 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Amyloid Neuropathies, Familial*
Amyloid beta-Peptides*
Aged ; Amyloid/metabolism ; Brain/metabolism ; Humans ; Prealbumin/metabolism
Czasopismo naukowe
Tytuł :
EK100 and Antrodin C Improve Brain Amyloid Pathology in APP/PS1 Transgenic Mice by Promoting Microglial and Perivascular Clearance Pathways.
Autorzy :
Tsay HJ; Institute of Neuroscience, School of Life Science, National Yang-Ming Chiao Tung University, Taipei 112, Taiwan.
Liu HK; National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei 112, Taiwan.; Program in Clinical Drug Development of Chinese Medicine, Taipei Medical University, Taipei 112, Taiwan.
Kuo YH; Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan.; Department of Biotechnology, Asia University, Taichung 413, Taiwan.; Chinese Medicine Research Center, China Medical University, Taichung 404, Taiwan.
Chiu CS; Institute of Biopharmaceutical Science, National Yang-Ming Chiao Tung University, Taipei 112, Taiwan.
Liang CC; Institute of Anatomy and Cell Biology, National Yang-Ming Chiao Tung University, Taipei 112, Taiwan.
Chung CW; Institute of Traditional Medicine, National Yang-Ming Chiao Tung University, Taipei 112, Taiwan.
Chen CC; Biotech Research Institute, Grape King Bio Ltd., Taoyuan City 320, Taiwan.
Chen YP; Biotech Research Institute, Grape King Bio Ltd., Taoyuan City 320, Taiwan.
Shiao YJ; National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei 112, Taiwan.; Program in Clinical Drug Development of Chinese Medicine, Taipei Medical University, Taipei 112, Taiwan.; Institute of Biopharmaceutical Science, National Yang-Ming Chiao Tung University, Taipei 112, Taiwan.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Sep 27; Vol. 22 (19). Date of Electronic Publication: 2021 Sep 27.
Typ publikacji :
Journal Article
MeSH Terms :
Alzheimer Disease*/drug therapy
Alzheimer Disease*/genetics
Alzheimer Disease*/metabolism
Maleimides*/chemistry
Maleimides*/pharmacology
Plaque, Amyloid*/drug therapy
Plaque, Amyloid*/genetics
Plaque, Amyloid*/metabolism
Amyloid beta-Protein Precursor/*metabolism
Microglia/*metabolism
Polyporales/*chemistry
Presenilin-1/*metabolism
Amyloid beta-Protein Precursor/genetics ; Animals ; Cell Line ; Mice ; Mice, Transgenic ; Microglia/pathology ; Presenilin-1/genetics
SCR Organism :
Taiwanofungus camphoratus
Czasopismo naukowe
Tytuł :
Amyloid β production along the neuronal secretory pathway: Dangerous liaisons in the Golgi?
Autorzy :
Fourriere L; The Department of Biochemistry and Pharmacology and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia.
Gleeson PA; The Department of Biochemistry and Pharmacology and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia.
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Źródło :
Traffic (Copenhagen, Denmark) [Traffic] 2021 Sep; Vol. 22 (9), pp. 319-327. Date of Electronic Publication: 2021 Jul 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alzheimer Disease*
Amyloid beta-Peptides*/metabolism
Amyloid Precursor Protein Secretases/metabolism ; Amyloid beta-Protein Precursor/metabolism ; Aspartic Acid Endopeptidases/metabolism ; Humans ; Neurons/metabolism ; Protein Transport ; Secretory Pathway
Czasopismo naukowe
Tytuł :
Transthyretin amyloid-related transitory events (TARTEs): Descriptive analysis of clinical, imagiological, and neurophysiological features.
Autorzy :
Carvalho V; Department of Neurology, Hospital Pedro Hispano/Matosinhos Local Unit, Matosinhos, Portugal. Electronic address: .
Cunha C; Medical Practitioner, Lismore GP Superclinic, Goonellabah, Australia.
Rocha R; Department of Neurology, Hospital Pedro Hispano/Matosinhos Local Unit, Matosinhos, Portugal.
Massano J; Department of Neurology, Centro Hospitalar Universitário São João, Porto, Portugal; Department of Clinical Neurosciences and Mental Health, Faculty of Medicine University of Porto, Porto, Portugal.
Correia F; Department of Neurology, Hospital Pedro Hispano/Matosinhos Local Unit, Matosinhos, Portugal.
Coelho P; Department of Neurology, Hospital Pedro Hispano/Matosinhos Local Unit, Matosinhos, Portugal.
França S; Department of Neurology, Hospital Pedro Hispano/Matosinhos Local Unit, Matosinhos, Portugal.
Cruz VT; Department of Neurology, Hospital Pedro Hispano/Matosinhos Local Unit, Matosinhos, Portugal; Epidemiologic Research Unit, Public Health Institute, University of Porto, Porto, Portugal.
Cruto C; Department of Neurology, Hospital Pedro Hispano/Matosinhos Local Unit, Matosinhos, Portugal.
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Źródło :
Journal of the neurological sciences [J Neurol Sci] 2021 Oct 15; Vol. 429, pp. 118068. Date of Electronic Publication: 2021 Sep 04.
Typ publikacji :
Journal Article
MeSH Terms :
Amyloid Neuropathies, Familial*/diagnostic imaging
Amyloid Neuropathies, Familial*/genetics
Prealbumin*/genetics
Amyloid/genetics ; Amyloidogenic Proteins ; Humans ; Phenotype
Czasopismo naukowe
Tytuł :
Physalin B reduces Aβ secretion through down-regulation of BACE1 expression by activating FoxO1 and inhibiting STAT3 phosphorylation.
Autorzy :
Zhang W; School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang 453003, China.
Bai SS; School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang 453003, China; Central Laboratory, the First Affiliated Hospital of Henan University of Science and Technology, Luoyang 471003, China.
Zhang Q; Grade 2019, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang 453003, China.
Shi RL; School of Public Health, Xinxiang Medical University, Xinxiang 453003, China.
Wang HC; School of Life and Pharmaceutical Sciences, Dalian University of Technology, Panjin 124221, China.
Liu YC; School of Basic Medical Sciences, Sanquan College of Xinxiang Medical University, Xinxiang 453003, China.
Ni TJ; School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang 453003, China.
Wu Y; School of Nursing Care, Xinxiang Medical University, Xinxiang 453003, China.
Yao ZY; School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang 453003, China.
Sun Y; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China. Electronic address: .
Wang MY; School of Laboratory Medicine, Xinxiang Medical University, Xinxiang 453003, China; Xinxiang Key Laboratory of Immunoregulation and Molecular Diagnostics, Xinxiang 453003, China. Electronic address: .
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Źródło :
Chinese journal of natural medicines [Chin J Nat Med] 2021 Oct; Vol. 19 (10), pp. 732-740.
Typ publikacji :
Journal Article
MeSH Terms :
Alzheimer Disease*
Amyloid Precursor Protein Secretases*/genetics
Amyloid Precursor Protein Secretases*/metabolism
Amyloid beta-Peptides/metabolism ; Aspartic Acid Endopeptidases/genetics ; Aspartic Acid Endopeptidases/metabolism ; Down-Regulation ; Forkhead Box Protein O1/genetics ; Humans ; Phosphorylation ; STAT3 Transcription Factor/genetics ; STAT3 Transcription Factor/metabolism ; Secosteroids
Czasopismo naukowe
Tytuł :
Cerebrospinal fluid levels of the neurotrophic factor neuroleukin are increased in early Alzheimer's disease, but not in cerebral amyloid angiopathy.
Autorzy :
De Kort AM; Department of Neurology, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Centre, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands.
Kuiperij HB; Department of Neurology, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Centre, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands.
Alcolea D; Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.; Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), Madrid, Spain.
Kersten I; Department of Neurology, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Centre, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands.
Versleijen AAM; Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.
Greenberg SM; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Stoops E; ADx NeuroSciences, Ghent, Belgium.
Schreuder FHBM; Department of Neurology, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Centre, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands.
Klijn CJM; Department of Neurology, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Centre, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands.
Lleó A; Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.; Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), Madrid, Spain.
Claassen JAHR; Department of Geriatrics, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Centre, Nijmegen, The Netherlands.
Verbeek MM; Department of Neurology, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Centre, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands. .; Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, The Netherlands. .
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Źródło :
Alzheimer's research & therapy [Alzheimers Res Ther] 2021 Sep 24; Vol. 13 (1), pp. 160. Date of Electronic Publication: 2021 Sep 24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Alzheimer Disease*/complications
Cerebral Amyloid Angiopathy*/complications
Amyloid beta-Peptides ; Biomarkers ; Glucose-6-Phosphate Isomerase ; Humans ; Nerve Growth Factors ; Protein-Serine-Threonine Kinases
Czasopismo naukowe
Tytuł :
Characterization of a Conformation-Restricted Amyloid β Peptide and Immunoreactivity of Its Antibody in Human AD brain.
Autorzy :
Kageyama Y; Molecular Neuroscience Research Center, Shiga University of Medical Science, Shiga 520-2192, Japan.
Irie Y; Division of Food Science & Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan.
Matsushima Y; Division of Food Science & Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan.
Segawa T; Immuno-Biological Laboratories Co., Ltd., Fujioka-Shi, Gunma 375-0005, Japan.
Bellier JP; Molecular Neuroscience Research Center, Shiga University of Medical Science, Shiga 520-2192, Japan.
Hidaka K; Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan.
Sugiyama H; Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan.
Kaneda D; Choju Medical Institute, Fukushimura Hospital, 19-14 Noyoricho, Yamanaka, Aichi 441-8124, Japan.
Hashizume Y; Choju Medical Institute, Fukushimura Hospital, 19-14 Noyoricho, Yamanaka, Aichi 441-8124, Japan.
Akatsu H; Choju Medical Institute, Fukushimura Hospital, 19-14 Noyoricho, Yamanaka, Aichi 441-8124, Japan.; Department of Community-Based Medical Education, Nagoya City University Graduate School of Medicine, Nagoya, Aichi 467-8601, Japan.
Miki K; Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan.
Kita A; Institute for Integrated Radiation and Nuclear Science, Kyoto University, Kumatori, Sennan, Osaka 590-0494, Japan.
Walker DG; Molecular Neuroscience Research Center, Shiga University of Medical Science, Shiga 520-2192, Japan.
Irie K; Division of Food Science & Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan.
Tooyama I; Molecular Neuroscience Research Center, Shiga University of Medical Science, Shiga 520-2192, Japan.
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Źródło :
ACS chemical neuroscience [ACS Chem Neurosci] 2021 Sep 15; Vol. 12 (18), pp. 3418-3432. Date of Electronic Publication: 2021 Aug 31.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alzheimer Disease*
Amyloid beta-Peptides*/metabolism
Amyloid ; Brain/metabolism ; Humans ; Peptide Fragments ; Plaque, Amyloid
Czasopismo naukowe
Tytuł :
OAB-14 Effectively Ameliorates the Dysfunction of the Endosomal-Autophagic-Lysosomal Pathway in APP/PS1 Transgenic Mice.
Autorzy :
Guo X; Department of Pharmacology, Life Science and Biopharmaceutics School, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, Liaoning 110016, P. R. China.
Bao X; Key Laboratory of Structure-Based Drugs Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, Liaoning 110016, P. R. China.
Wang X; Department of Pharmacology, Life Science and Biopharmaceutics School, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, Liaoning 110016, P. R. China.
Liu D; Department of Pharmacology, Life Science and Biopharmaceutics School, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, Liaoning 110016, P. R. China.
Liu P; Department of Pharmacology, Life Science and Biopharmaceutics School, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, Liaoning 110016, P. R. China.
Chi T; Department of Pharmacology, Life Science and Biopharmaceutics School, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, Liaoning 110016, P. R. China.
Ji X; Department of Pharmacology, Life Science and Biopharmaceutics School, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, Liaoning 110016, P. R. China.
Zheng Z; Shandong Xinhua Pharmaceutical Co., Ltd., Zibo, Shandong 255086, P. R. China.
Chen G; Key Laboratory of Structure-Based Drugs Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, Liaoning 110016, P. R. China.
Zou L; Department of Pharmacology, Life Science and Biopharmaceutics School, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, Liaoning 110016, P. R. China.
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Źródło :
ACS chemical neuroscience [ACS Chem Neurosci] 2021 Nov 03; Vol. 12 (21), pp. 3985-3993. Date of Electronic Publication: 2021 Oct 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alzheimer Disease*/drug therapy
Amyloid beta-Peptides*
Amyloid beta-Protein Precursor/genetics ; Animals ; Autophagy ; Disease Models, Animal ; Lysosomes ; Mice ; Mice, Transgenic
Czasopismo naukowe
Tytuł :
Extracellular-Signal-Regulated Kinase Inhibition Switches APP Processing from β- to α-Secretase under Oxidative Stress: Modulation of ADAM10 by SIRT1/NF-κB Signaling.
Autorzy :
Thonda S; Department of Applied Biology, CSIR─Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad 500007, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.
Puttapaka SN; Department of Applied Biology, CSIR─Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad 500007, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.
Kona SV; Department of Applied Biology, CSIR─Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad 500007, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.
Kalivendi SV; Department of Applied Biology, CSIR─Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad 500007, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.
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Źródło :
ACS chemical neuroscience [ACS Chem Neurosci] 2021 Nov 03; Vol. 12 (21), pp. 4175-4186. Date of Electronic Publication: 2021 Oct 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alzheimer Disease*/drug therapy
Amyloid Precursor Protein Secretases*/metabolism
ADAM10 Protein/metabolism ; Amyloid beta-Protein Precursor/genetics ; Amyloid beta-Protein Precursor/metabolism ; Animals ; Aspartic Acid Endopeptidases/metabolism ; Cell Line, Tumor ; Extracellular Signal-Regulated MAP Kinases ; Hydrogen Peroxide ; NF-kappa B ; Oxidative Stress ; Rats ; Sirtuin 1
Czasopismo naukowe
Tytuł :
The apolipoprotein receptor LRP3 compromises APP levels.
Autorzy :
Cuchillo-Ibañez I; Instituto de Neurociencias de Alicante, Universidad Miguel Hernández de Elche-CSIC, Sant Joan d'Alacant, Spain. .; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain. .; Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), Alicante, Spain. .
Lennol MP; Instituto de Neurociencias de Alicante, Universidad Miguel Hernández de Elche-CSIC, Sant Joan d'Alacant, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
Escamilla S; Instituto de Neurociencias de Alicante, Universidad Miguel Hernández de Elche-CSIC, Sant Joan d'Alacant, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
Mata-Balaguer T; Instituto de Neurociencias de Alicante, Universidad Miguel Hernández de Elche-CSIC, Sant Joan d'Alacant, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
Valverde-Vozmediano L; Instituto de Neurociencias de Alicante, Universidad Miguel Hernández de Elche-CSIC, Sant Joan d'Alacant, Spain.
Lopez-Font I; Instituto de Neurociencias de Alicante, Universidad Miguel Hernández de Elche-CSIC, Sant Joan d'Alacant, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.; Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), Alicante, Spain.
Ferrer I; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.; Instituto de Neuropatología, Hospital Universitario de Bellvitge, Universidad de Barcelona, Hospitalet de Llobregat, Barcelona, Spain.
Sáez-Valero J; Instituto de Neurociencias de Alicante, Universidad Miguel Hernández de Elche-CSIC, Sant Joan d'Alacant, Spain. .; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain. .; Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), Alicante, Spain. .
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Źródło :
Alzheimer's research & therapy [Alzheimers Res Ther] 2021 Nov 02; Vol. 13 (1), pp. 181. Date of Electronic Publication: 2021 Nov 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alzheimer Disease*/genetics
Amyloid beta-Protein Precursor*/genetics
LDL-Receptor Related Proteins*/genetics
Amyloid beta-Peptides ; Animals ; Apolipoproteins ; Humans ; Middle Aged
Czasopismo naukowe
Tytuł :
Loss of APP in mice increases thigmotaxis and is associated with elevated brain expression of IL-13 and IP-10/CXCL10.
Autorzy :
Mayagoitia K; Department of Pathology and Human Anatomy, School of Medicine, Loma Linda University, 24785 Stewart, St., Loma Linda, CA, 92354, United States.
Tolan AJ; Department of Pathology and Human Anatomy, School of Medicine, Loma Linda University, 24785 Stewart, St., Loma Linda, CA, 92354, United States.
Shammi S; Department of Pathology and Human Anatomy, School of Medicine, Loma Linda University, 24785 Stewart, St., Loma Linda, CA, 92354, United States.
Shin SD; Department of Pathology and Human Anatomy, School of Medicine, Loma Linda University, 24785 Stewart, St., Loma Linda, CA, 92354, United States.
Menchaca JA; Department of Pathology and Human Anatomy, School of Medicine, Loma Linda University, 24785 Stewart, St., Loma Linda, CA, 92354, United States.
Figueroa JD; Department of Basic Sciences, Center for Health Disparities and Molecular Medicine, Loma Linda University School of Medicine, Loma Linda CA, United States.
Wilson CG; Lawrence D. Longo, MD Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, CA, United States.
Bellinger DL; Department of Pathology and Human Anatomy, School of Medicine, Loma Linda University, 24785 Stewart, St., Loma Linda, CA, 92354, United States.
Ahmed ASI; Lawrence D. Longo, MD Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, CA, United States.
Soriano S; Department of Pathology and Human Anatomy, School of Medicine, Loma Linda University, 24785 Stewart, St., Loma Linda, CA, 92354, United States. Electronic address: .
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Źródło :
Physiology & behavior [Physiol Behav] 2021 Oct 15; Vol. 240, pp. 113533. Date of Electronic Publication: 2021 Jul 19.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Alzheimer Disease*
Amyloid beta-Protein Precursor*/genetics
Amyloid beta-Peptides/metabolism ; Animals ; Brain/metabolism ; Chemokine CXCL10/genetics ; Disease Models, Animal ; Female ; Interleukin-13 ; Male ; Maze Learning ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic
Czasopismo naukowe
Tytuł :
Citrullination of Amyloid-β Peptides in Alzheimer's Disease.
Autorzy :
Mukherjee S; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria 3010, Australia.
Perez KA; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria 3010, Australia.
Dubois C; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria 3010, Australia.
Nisbet RM; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria 3010, Australia.; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia.
Li QX; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria 3010, Australia.
Varghese S; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria 3010, Australia.
Jin L; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria 3010, Australia.
Birchall I; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria 3010, Australia.
Streltsov VA; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria 3010, Australia.
Vella LJ; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria 3010, Australia.; Department of Surgery, The University of Melbourne, The Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria 3010, Australia.
McLean C; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria 3010, Australia.; Department of Anatomical Pathology, Alfred Hospital, Prahran, Victoria 3004, Australia.
Barham KJ; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria 3010, Australia.
Roberts BR; Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia 30322, United States.; Department of Neurology, Emory University School of Medicine, Atlanta, Georgia 30322, United States.
Masters CL; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria 3010, Australia.
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Źródło :
ACS chemical neuroscience [ACS Chem Neurosci] 2021 Oct 06; Vol. 12 (19), pp. 3719-3732. Date of Electronic Publication: 2021 Sep 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alzheimer Disease*
Amyloid beta-Peptides*/metabolism
Brain/metabolism ; Citrullination ; Humans ; Plaque, Amyloid
Czasopismo naukowe
Tytuł :
Artificial Chiral Interfaces against Amyloid-β Peptide Aggregation: Research Progress and Challenges.
Autorzy :
Zhou Z; Department of Neurology, The First Hospital of Lanzhou University, Lanzhou 730000, China.
Gu YQ; Department of Neurology, The First Hospital of Lanzhou University, Lanzhou 730000, China.
Wang HX; College of Chemistry and Chemical Engineering, Hubei University, Wuhan 430062, China.
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Źródło :
ACS chemical neuroscience [ACS Chem Neurosci] 2021 Nov 17; Vol. 12 (22), pp. 4236-4248. Date of Electronic Publication: 2021 Nov 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Alzheimer Disease*/drug therapy
Amyloid beta-Peptides*
Amyloid ; Humans
Czasopismo naukowe
Tytuł :
Recognition and Implications of Undiagnosed Cardiac Amyloid Patients in HFpEF Trials.
Autorzy :
Cheng RK; Division of Cardiology, University of Washington, Seattle, Washington, USA.
Maurer MS; Division of Cardiology, Columbia University Irving Medical Center, New York, New York, USA. Electronic address: .
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Źródło :
JACC. Heart failure [JACC Heart Fail] 2021 Nov; Vol. 9 (11), pp. 803-806. Date of Electronic Publication: 2021 Sep 08.
Typ publikacji :
Editorial; Research Support, N.I.H., Extramural
MeSH Terms :
Amyloid Neuropathies, Familial*
Cardiomyopathies*
Heart Failure*/diagnosis
Heart Failure*/therapy
Amyloid ; Humans ; Prealbumin ; Stroke Volume
Raport
Tytuł :
Strong inhibition of peptide amyloid formation by a fatty acid.
Autorzy :
Pallbo J; Division of Physical Chemistry, Department of Chemistry, Lund University, Lund, Sweden. Electronic address: .
Olsson U; Division of Physical Chemistry, Department of Chemistry, Lund University, Lund, Sweden.
Sparr E; Division of Physical Chemistry, Department of Chemistry, Lund University, Lund, Sweden.
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Źródło :
Biophysical journal [Biophys J] 2021 Oct 19; Vol. 120 (20), pp. 4536-4546. Date of Electronic Publication: 2021 Sep 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amyloid*
Fatty Acids*
Amyloid beta-Peptides ; Circular Dichroism ; Hydrophobic and Hydrophilic Interactions ; Peptide Fragments ; alpha-Synuclein
Czasopismo naukowe
Tytuł :
Interaction of Amyloid-β-(1-42) Peptide and Its Aggregates with Lipid/Water Interfaces Probed by Vibrational Sum-Frequency Generation Spectroscopy.
Autorzy :
Strazdaite S; Department of Organic Chemistry, Center for Physical Sciences and Technology, Sauletekio Ave. 3, Vilnius LT-10257, Lithuania.
Roeters SJ; Department of Chemistry, Aarhus University, Langelandsgade 140, 8000 Aarhus C, Denmark.
Sakalauskas A; Institute of Biotechnology, Life Sciences Center, Vilnius University, Sauletekio 7, LT-10257 Vilnius, Lithuania.
Sneideris T; Institute of Biotechnology, Life Sciences Center, Vilnius University, Sauletekio 7, LT-10257 Vilnius, Lithuania.
Kirschner J; Institute of Solid State Physics, TU Wien, Wiedner Hauptstrasse 8-10, 1040 Vienna, Austria.
Pedersen KB; Department of Chemistry, Aarhus University, Langelandsgade 140, 8000 Aarhus C, Denmark.
Schiøtt B; Department of Chemistry, Aarhus University, Langelandsgade 140, 8000 Aarhus C, Denmark.
Jensen F; Department of Chemistry, Aarhus University, Langelandsgade 140, 8000 Aarhus C, Denmark.
Weidner T; Department of Chemistry, Aarhus University, Langelandsgade 140, 8000 Aarhus C, Denmark.
Smirnovas V; Institute of Biotechnology, Life Sciences Center, Vilnius University, Sauletekio 7, LT-10257 Vilnius, Lithuania.
Niaura G; Department of Organic Chemistry, Center for Physical Sciences and Technology, Sauletekio Ave. 3, Vilnius LT-10257, Lithuania.
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Źródło :
The journal of physical chemistry. B [J Phys Chem B] 2021 Oct 14; Vol. 125 (40), pp. 11208-11218. Date of Electronic Publication: 2021 Oct 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amyloid beta-Peptides*
Water*
Amyloid ; Lipids ; Microscopy, Atomic Force ; Spectrum Analysis
Czasopismo naukowe
Tytuł :
Aducanumab and the "post-amyloid" era of Alzheimer research?
Autorzy :
Musiek ES; Department of Neurology, Knight Alzheimer's Disease Research Center, Washington University School of Medicine in St. Louis, St. Louis, MO, USA. Electronic address: .
Bennett DA; Rush Alzheimer's Disease Center, Rush Medical College, Rush University Medical Center, Chicago, IL, USA. Electronic address: .
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Źródło :
Neuron [Neuron] 2021 Oct 06; Vol. 109 (19), pp. 3045-3047. Date of Electronic Publication: 2021 Sep 27.
Typ publikacji :
Historical Article; Journal Article
MeSH Terms :
Amyloid*
Alzheimer Disease/*drug therapy
Antibodies, Monoclonal, Humanized/*therapeutic use
Aged ; Aged, 80 and over ; Device Approval ; History, 19th Century ; History, 20th Century ; Humans ; Immunotherapy ; Middle Aged ; Plaque, Amyloid
Czasopismo naukowe
Tytuł :
Micro-Raman spectroscopy of lipid halo and dense-core amyloid plaques: aging process characterization in the Alzheimer's disease APPswePS1ΔE9 mouse model.
Autorzy :
Fonseca EA; Departamento de Física, ICEx, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil. .; Programa de Pós-Graduação em Inovação Tecnológica e Biofarmacêutica, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil.
Lafeta L; Departamento de Física, ICEx, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil. .
Luiz Campos J; Departamento de Física, ICEx, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil. .
Cunha R; Departamento de Física, ICEx, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil. .
Barbosa A; Departamento de Física, ICEx, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil. .; Departamento de Oftalmologia, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 30130-100, Brazil.
Romano-Silva MA; Departamento de Saúde Mental, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 30130-100, Brazil.
Vieira R; Departamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil.
Malard LM; Departamento de Física, ICEx, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil. .
Jorio A; Departamento de Física, ICEx, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil. .; Programa de Pós-Graduação em Inovação Tecnológica e Biofarmacêutica, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil.
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Źródło :
The Analyst [Analyst] 2021 Sep 27; Vol. 146 (19), pp. 6014-6025. Date of Electronic Publication: 2021 Sep 27.
Typ publikacji :
Journal Article
MeSH Terms :
Alzheimer Disease*/diagnosis
Plaque, Amyloid*
Aging ; Amyloid beta-Peptides ; Animals ; Brain ; Lipids ; Mice ; Mice, Transgenic ; Spectrum Analysis, Raman
Czasopismo naukowe

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