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Wyszukujesz frazę ""Amyloid beta-Protein Precursor"" wg kryterium: Temat


Tytuł :
Treadmill Exercise Ameliorates Adult Hippocampal Neurogenesis Possibly by Adjusting the APP Proteolytic Pathway in APP/PS1 Transgenic Mice.
Autorzy :
Yu H; Key Laboratory of Adolescent Health Assessment and Exercise Intervention of Ministry of Education, East China Normal University, Shanghai 200241, China.; School of Physical Education and Health Care, East China Normal University, Shanghai 200241, China.
Zhang C; Key Laboratory of Adolescent Health Assessment and Exercise Intervention of Ministry of Education, East China Normal University, Shanghai 200241, China.; School of Physical Education and Health Care, East China Normal University, Shanghai 200241, China.
Xia J; Key Laboratory of Adolescent Health Assessment and Exercise Intervention of Ministry of Education, East China Normal University, Shanghai 200241, China.; School of Physical Education and Health Care, East China Normal University, Shanghai 200241, China.
Xu B; Key Laboratory of Adolescent Health Assessment and Exercise Intervention of Ministry of Education, East China Normal University, Shanghai 200241, China.; School of Physical Education and Health Care, East China Normal University, Shanghai 200241, China.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Sep 03; Vol. 22 (17). Date of Electronic Publication: 2021 Sep 03.
Typ publikacji :
Journal Article
MeSH Terms :
Neurogenesis*
Physical Conditioning, Animal*
Proteolysis*
Alzheimer Disease/*metabolism
Amyloid beta-Protein Precursor/*metabolism
Hippocampus/*metabolism
Alzheimer Disease/genetics ; Alzheimer Disease/pathology ; Amyloid beta-Protein Precursor/genetics ; Animals ; Disease Models, Animal ; Hippocampus/pathology ; Humans ; Mice ; Mice, Transgenic
Czasopismo naukowe
Tytuł :
Dysregulated APP expression and α-secretase processing of APP is involved in manganese-induced cognitive impairment.
Autorzy :
Yang Y; Department of Toxicology, School of Public Health, Guangxi Medical University, Nanning 530021, Guangxi, China; Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning 530021, Guangxi, China.
Zhang J; Department of Toxicology, School of Public Health, Guangxi Medical University, Nanning 530021, Guangxi, China.
Yang X; Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, Nanning 530021, Guangxi, China.
Li Z; Department of Toxicology, School of Public Health, Guangxi Medical University, Nanning 530021, Guangxi, China.
Wang J; Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, Nanning 530021, Guangxi, China.
Lu C; Department of Nutrition and Food Hygiene, School of Public Health, Guangxi Medical University, Nanning 530021, Guangxi, China.
Nan A; Department of Toxicology, School of Public Health, Guangxi Medical University, Nanning 530021, Guangxi, China. Electronic address: .
Zou Y; Department of Toxicology, School of Public Health, Guangxi Medical University, Nanning 530021, Guangxi, China; Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning 530021, Guangxi, China. Electronic address: .
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Źródło :
Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2021 Sep 01; Vol. 220, pp. 112365. Date of Electronic Publication: 2021 May 28.
Typ publikacji :
Journal Article
MeSH Terms :
Amyloid Precursor Protein Secretases/*metabolism
Amyloid beta-Protein Precursor/*metabolism
Cognitive Dysfunction/*chemically induced
Manganese/*toxicity
Amyloid Precursor Protein Secretases/genetics ; Amyloid beta-Protein Precursor/genetics ; Animals ; Cell Line ; Cognitive Dysfunction/metabolism ; Cognitive Dysfunction/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Synapses/drug effects ; Synapses/metabolism ; Synapses/pathology
Czasopismo naukowe
Tytuł :
Tyrosine O -GalNAc Alters the Conformation and Proteolytic Susceptibility of APP Model Glycopeptides.
Autorzy :
Singh Y; Department of Chemistry and Biochemistry, Charles E, Schmidt College of Science, Florida Atlantic University, 777 Glades Road, Boca Raton, Florida 33431, United States.
Ormaza D; Department of Chemistry and Biochemistry, Charles E, Schmidt College of Science, Florida Atlantic University, 777 Glades Road, Boca Raton, Florida 33431, United States.
Massetti A; Department of Chemistry and Biochemistry, Charles E, Schmidt College of Science, Florida Atlantic University, 777 Glades Road, Boca Raton, Florida 33431, United States.
Minond D; College of Pharmacy and Rumbaugh-Goodwin Institute for Cancer Research, Nova Southeastern University, 3301 College Ave, Fort Lauderdale, Florida 33314, United States.
Cudic M; Department of Chemistry and Biochemistry, Charles E, Schmidt College of Science, Florida Atlantic University, 777 Glades Road, Boca Raton, Florida 33431, United States.
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Źródło :
ACS chemical neuroscience [ACS Chem Neurosci] 2021 Aug 18; Vol. 12 (16), pp. 2974-2980. Date of Electronic Publication: 2021 Jul 29.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Alzheimer Disease*
Amyloid beta-Protein Precursor*/genetics
Amyloid Precursor Protein Secretases ; Amyloid beta-Peptides ; Glycopeptides ; Humans ; Tyrosine
Czasopismo naukowe
Tytuł :
The Amyloid Precursor Protein C99 Fragment Modulates Voltage-Gated Potassium Channels.
Autorzy :
Manville RW; Bioelectricity Laboratory, Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA, USA.
Abbott GW; Bioelectricity Laboratory, Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA, USA, .
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Źródło :
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology [Cell Physiol Biochem] 2021 Jul 28; Vol. 55 (S3), pp. 157-170.
Typ publikacji :
Journal Article
MeSH Terms :
Amyloid beta-Protein Precursor/*pharmacology
KCNQ Potassium Channels/*genetics
KCNQ2 Potassium Channel/*genetics
KCNQ3 Potassium Channel/*genetics
Peptide Fragments/*pharmacology
Amino Acid Sequence ; Amyloid beta-Protein Precursor/genetics ; Amyloid beta-Protein Precursor/metabolism ; Animals ; Anthracenes/pharmacology ; Gene Expression ; Humans ; KCNQ Potassium Channels/metabolism ; KCNQ2 Potassium Channel/metabolism ; KCNQ3 Potassium Channel/metabolism ; Membrane Potentials/drug effects ; Membrane Potentials/physiology ; Oocytes/cytology ; Oocytes/drug effects ; Oocytes/metabolism ; Patch-Clamp Techniques ; Peptide Fragments/genetics ; Peptide Fragments/metabolism ; Ranvier's Nodes/drug effects ; Ranvier's Nodes/metabolism ; Rats ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Sciatic Nerve/drug effects ; Sciatic Nerve/metabolism ; Sequence Alignment ; Sequence Homology, Amino Acid ; Tetraethylammonium/pharmacology ; Xenopus laevis
Czasopismo naukowe
Tytuł :
Molecular Details of a Coupled Binding and Folding Reaction between the Amyloid Precursor Protein and a Folded Domain.
Autorzy :
Jensen TMT; Center for Biopharmaceuticals, Department of Drug Design and Pharmacology, University of Copenhagen, Jagtvej 162, 2100 Copenhagen, Denmark.; Department of Medical Biochemistry and Microbiology, Uppsala University, BMC, Box 582, SE-75123 Uppsala, Sweden.
Bartling CRO; Center for Biopharmaceuticals, Department of Drug Design and Pharmacology, University of Copenhagen, Jagtvej 162, 2100 Copenhagen, Denmark.
Karlsson OA; Department of Medical Biochemistry and Microbiology, Uppsala University, BMC, Box 582, SE-75123 Uppsala, Sweden.
Åberg E; Department of Medical Biochemistry and Microbiology, Uppsala University, BMC, Box 582, SE-75123 Uppsala, Sweden.
Haugaard-Kedström LM; Center for Biopharmaceuticals, Department of Drug Design and Pharmacology, University of Copenhagen, Jagtvej 162, 2100 Copenhagen, Denmark.
Strømgaard K; Center for Biopharmaceuticals, Department of Drug Design and Pharmacology, University of Copenhagen, Jagtvej 162, 2100 Copenhagen, Denmark.
Jemth P; Department of Medical Biochemistry and Microbiology, Uppsala University, BMC, Box 582, SE-75123 Uppsala, Sweden.
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Źródło :
ACS chemical biology [ACS Chem Biol] 2021 Jul 16; Vol. 16 (7), pp. 1191-1200. Date of Electronic Publication: 2021 Jun 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amyloid beta-Protein Precursor/*metabolism
Cadherins/*metabolism
Carrier Proteins/*metabolism
Nerve Tissue Proteins/*metabolism
Amyloid beta-Protein Precursor/chemical synthesis ; Amyloid beta-Protein Precursor/genetics ; Animals ; Cadherins/chemical synthesis ; Cadherins/genetics ; Carrier Proteins/chemical synthesis ; Carrier Proteins/genetics ; Hydrogen Bonding ; Hydrophobic and Hydrophilic Interactions ; Intrinsically Disordered Proteins/chemical synthesis ; Intrinsically Disordered Proteins/genetics ; Intrinsically Disordered Proteins/metabolism ; Kinetics ; Mutation ; Nerve Tissue Proteins/chemical synthesis ; Nerve Tissue Proteins/genetics ; Protein Binding ; Protein Domains/genetics ; Protein Engineering ; Protein Folding ; Rats ; Thermodynamics
Czasopismo naukowe
Tytuł :
Levetiracetam Treatment Normalizes Levels of Presynaptic Endocytosis Machinery and Restores Nonamyloidogenic APP Processing in App Knock-in Mice.
Autorzy :
Rao NR; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, United States.
Savas JN; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, United States.
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Źródło :
Journal of proteome research [J Proteome Res] 2021 Jul 02; Vol. 20 (7), pp. 3580-3589. Date of Electronic Publication: 2021 Jun 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Alzheimer Disease*/drug therapy
Alzheimer Disease*/genetics
Amyloid beta-Protein Precursor*/genetics
Amyloid Precursor Protein Secretases ; Amyloid beta-Peptides ; Animals ; Disease Models, Animal ; Endocytosis ; Humans ; Levetiracetam/pharmacology ; Mice ; Mice, Transgenic ; Proteomics
Czasopismo naukowe
Tytuł :
CK1δ-Derived Peptides as Novel Tools Inhibiting the Interactions between CK1δ and APP695 to Modulate the Pathogenic Metabolism of APP.
Autorzy :
Roth A; Surgery Centre, Department of General and Visceral Surgery, Ulm University Hospital, Albert-Einstein-Allee 23, 89081 Ulm, Germany.
Gärtner F; Surgery Centre, Department of General and Visceral Surgery, Ulm University Hospital, Albert-Einstein-Allee 23, 89081 Ulm, Germany.
Mayer K; Surgery Centre, Department of General and Visceral Surgery, Ulm University Hospital, Albert-Einstein-Allee 23, 89081 Ulm, Germany.
Beyrle J; Surgery Centre, Department of General and Visceral Surgery, Ulm University Hospital, Albert-Einstein-Allee 23, 89081 Ulm, Germany.
König I; Surgery Centre, Department of General and Visceral Surgery, Ulm University Hospital, Albert-Einstein-Allee 23, 89081 Ulm, Germany.
Knippschild U; Surgery Centre, Department of General and Visceral Surgery, Ulm University Hospital, Albert-Einstein-Allee 23, 89081 Ulm, Germany.
Bischof J; Surgery Centre, Department of General and Visceral Surgery, Ulm University Hospital, Albert-Einstein-Allee 23, 89081 Ulm, Germany.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jun 15; Vol. 22 (12). Date of Electronic Publication: 2021 Jun 15.
Typ publikacji :
Journal Article
MeSH Terms :
Amyloid beta-Protein Precursor/*metabolism
Casein Kinase Idelta/*metabolism
Peptides/*metabolism
Amyloid beta-Protein Precursor/chemistry ; Casein Kinase Idelta/chemistry ; Cell Death ; Cell Survival ; Humans ; Molecular Docking Simulation ; Neurons/metabolism ; Phosphorylation ; Plaque, Amyloid/metabolism ; Plaque, Amyloid/pathology ; Protein Binding
Czasopismo naukowe
Tytuł :
Effect of Global Brain Ischemia on Amyloid Precursor Protein Metabolism and Expression of Amyloid-Degrading Enzymes in Rat Cortex: Role in Pathogenesis of Alzheimer's Disease.
Autorzy :
Babusikova E; Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin, Department of Medical Biochemistry, Martin, 036 01, Slovakia. .
Dobrota D; Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin, Department of Medical Biochemistry, Martin, 036 01, Slovakia. .
Turner AJ; School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, United Kingdom. .
Nalivaeva NN; School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, United Kingdom. .; Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, 194223, Russia.
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Źródło :
Biochemistry. Biokhimiia [Biochemistry (Mosc)] 2021 Jun; Vol. 86 (6), pp. 680-692.
Typ publikacji :
Journal Article
MeSH Terms :
Alzheimer Disease/*etiology
Amyloid Precursor Protein Secretases/*metabolism
Amyloid beta-Protein Precursor/*metabolism
Brain Ischemia/*metabolism
Cerebral Cortex/*metabolism
Alzheimer Disease/metabolism ; Amyloid Precursor Protein Secretases/genetics ; Amyloid beta-Protein Precursor/genetics ; Animals ; Brain Ischemia/complications ; Brain Ischemia/enzymology ; Cerebral Cortex/enzymology ; Endothelin-Converting Enzymes/genetics ; Endothelin-Converting Enzymes/metabolism ; Gene Expression Regulation ; Insulysin/genetics ; Insulysin/metabolism ; Male ; Neprilysin/genetics ; Neprilysin/metabolism ; Oxidative Stress ; Rats ; Rats, Wistar ; Reperfusion Injury/complications ; Reperfusion Injury/enzymology ; Reperfusion Injury/metabolism
Czasopismo naukowe
Tytuł :
The Density of Group I mGlu 5 Receptors Is Reduced along the Neuronal Surface of Hippocampal Cells in a Mouse Model of Alzheimer's Disease.
Autorzy :
Martín-Belmonte A; Synaptic Structure Laboratory, Instituto de Investigación en Discapacidades Neurológicas (IDINE), Departamento de Ciencias Médicas, Facultad de Medicina, Universidad de Castilla-La Mancha, Campus Biosanitario, C/Almansa 14, 02006 Albacete, Spain.
Aguado C; Synaptic Structure Laboratory, Instituto de Investigación en Discapacidades Neurológicas (IDINE), Departamento de Ciencias Médicas, Facultad de Medicina, Universidad de Castilla-La Mancha, Campus Biosanitario, C/Almansa 14, 02006 Albacete, Spain.
Alfaro-Ruiz R; Synaptic Structure Laboratory, Instituto de Investigación en Discapacidades Neurológicas (IDINE), Departamento de Ciencias Médicas, Facultad de Medicina, Universidad de Castilla-La Mancha, Campus Biosanitario, C/Almansa 14, 02006 Albacete, Spain.
Albasanz JL; Department of Inorganic, Organic and Biochemistry, Faculty of Chemical and Technological Sciences, Universidad de Castilla-La Mancha, School of Medicine of Ciudad Real, Regional Center of Biomedical Research (CRIB), 13071 Ciudad Real, Spain.
Martín M; Department of Inorganic, Organic and Biochemistry, Faculty of Chemical and Technological Sciences, Universidad de Castilla-La Mancha, School of Medicine of Ciudad Real, Regional Center of Biomedical Research (CRIB), 13071 Ciudad Real, Spain.
Moreno-Martínez AE; Synaptic Structure Laboratory, Instituto de Investigación en Discapacidades Neurológicas (IDINE), Departamento de Ciencias Médicas, Facultad de Medicina, Universidad de Castilla-La Mancha, Campus Biosanitario, C/Almansa 14, 02006 Albacete, Spain.
Fukazawa Y; Division of Brain Structure and Function, Research Center for Child Mental Development, Life Science Innovation Center, School of Medical Science, University of Fukui, Fukui 910-1193, Japan.
Luján R; Synaptic Structure Laboratory, Instituto de Investigación en Discapacidades Neurológicas (IDINE), Departamento de Ciencias Médicas, Facultad de Medicina, Universidad de Castilla-La Mancha, Campus Biosanitario, C/Almansa 14, 02006 Albacete, Spain.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 May 30; Vol. 22 (11). Date of Electronic Publication: 2021 May 30.
Typ publikacji :
Journal Article
MeSH Terms :
Alzheimer Disease/*genetics
Amyloid beta-Protein Precursor/*genetics
Cell Membrane/*metabolism
Hippocampus/*metabolism
Pyramidal Cells/*metabolism
Receptor, Metabotropic Glutamate 5/*genetics
Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Amyloid beta-Protein Precursor/metabolism ; Animals ; Cell Membrane/pathology ; Disease Models, Animal ; GTP-Binding Protein alpha Subunits, Gq-G11/genetics ; GTP-Binding Protein alpha Subunits, Gq-G11/metabolism ; Gene Expression Regulation ; Hippocampus/pathology ; Humans ; Male ; Mice ; Mice, Transgenic ; Phospholipase C beta/genetics ; Phospholipase C beta/metabolism ; Presenilin-1/genetics ; Presenilin-1/metabolism ; Pyramidal Cells/pathology ; Receptor, Metabotropic Glutamate 5/metabolism ; Synaptic Transmission
Czasopismo naukowe
Tytuł :
Alzheimer's Disease Animal Models: Elucidation of Biomarkers and Therapeutic Approaches for Cognitive Impairment.
Autorzy :
Nakai T; Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya 466-8560, Japan.
Yamada K; Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya 466-8560, Japan.
Mizoguchi H; Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya 466-8560, Japan.; Medical Interactive Research and Academia Industry Collaboration Center, Research Institute of Environmental Medicine, Nagoya University, Nagoya 464-8601, Japan.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 May 24; Vol. 22 (11). Date of Electronic Publication: 2021 May 24.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Disease Models, Animal*
Alzheimer Disease/*drug therapy
Alzheimer Disease/*metabolism
Amyloid beta-Protein Precursor/*metabolism
Cognitive Dysfunction/*metabolism
tau Proteins/*metabolism
Alzheimer Disease/pathology ; Amyloid beta-Protein Precursor/genetics ; Animals ; Biomarkers/metabolism ; Cognitive Dysfunction/pathology ; Gene Knock-In Techniques ; Mice ; Mice, Transgenic
Czasopismo naukowe
Tytuł :
Green Tea Epigallocatechin-3-gallate (EGCG) Targeting Protein Misfolding in Drug Discovery for Neurodegenerative Diseases.
Autorzy :
Gonçalves PB; Faculty of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro 21949-900, Brazil.
Sodero ACR; Faculty of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro 21949-900, Brazil.
Cordeiro Y; Faculty of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro 21949-900, Brazil.
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Źródło :
Biomolecules [Biomolecules] 2021 May 20; Vol. 11 (5). Date of Electronic Publication: 2021 May 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Amyloid beta-Protein Precursor/*chemistry
Catechin/*analogs & derivatives
Neurodegenerative Diseases/*metabolism
Tea/*chemistry
alpha-Synuclein/*chemistry
Alzheimer Disease/drug therapy ; Alzheimer Disease/metabolism ; Amyloid beta-Protein Precursor/drug effects ; Catechin/pharmacology ; Catechin/therapeutic use ; Drug Discovery ; Humans ; Molecular Targeted Therapy ; Neurodegenerative Diseases/drug therapy ; Parkinson Disease/drug therapy ; Parkinson Disease/metabolism ; Protein Aggregates/drug effects ; Protein Folding/drug effects ; alpha-Synuclein/drug effects
Czasopismo naukowe
Tytuł :
Phenotypic Differences between the Alzheimer's Disease-Related hAPP-J20 Model and Heterozygous Zbtb20 Knock-Out Mice.
Autorzy :
Gulbranson DR; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA 94158.
Ho K; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA 94158.
Yu GQ; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA 94158.
Yu X; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA 94158.
Das M; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA 94158.
Shao E; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA 94158.
Kim D; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA 94158.
Zhang WJ; Department of Pathophysiology, Naval Medical University, Shanghai 200433, China.
Choudhary K; Gladstone Institute of Data Science and Biotechnology, Gladstone Institutes, San Francisco, CA 94158.
Thomas R; Gladstone Institute of Data Science and Biotechnology, Gladstone Institutes, San Francisco, CA 94158.
Mucke L; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA 94158 .; Department of Neurology and Weill Institute for Neurosciences, University of California, San Francisco, CA 94158.
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Źródło :
ENeuro [eNeuro] 2021 May 13; Vol. 8 (3). Date of Electronic Publication: 2021 May 13 (Print Publication: 2021).
Typ publikacji :
Journal Article
MeSH Terms :
Alzheimer Disease*/genetics
Amyloid beta-Protein Precursor*/genetics
Amyloid beta-Peptides/genetics ; Animals ; Disease Models, Animal ; Mice ; Mice, Knockout ; Mice, Transgenic ; Phenotype ; Transcription Factors
Czasopismo naukowe
Tytuł :
Molecular Characteristics of Amyloid Precursor Protein (APP) and Its Effects in Cancer.
Autorzy :
Lee HN; Department of Molecular Biology, College of Natural Sciences, Pusan National University, Jangjeon-dong, Geumjeong-gu, Busan 46241, Korea.
Jeong MS; Insitute for Plastic Information and Energy Materials and Sustainable Utilization of Photovoltaic Energy Research Center, Pusan National University, Jangjeon-dong, Geumjeong-gu, Busan 46241, Korea.
Jang SB; Department of Molecular Biology, College of Natural Sciences, Pusan National University, Jangjeon-dong, Geumjeong-gu, Busan 46241, Korea.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 May 08; Vol. 22 (9). Date of Electronic Publication: 2021 May 08.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Amyloid beta-Protein Precursor/*metabolism
Neoplasms/*metabolism
Amyloid beta-Protein Precursor/chemistry ; Animals ; Humans ; Models, Biological ; Protein Processing, Post-Translational
Czasopismo naukowe
Tytuł :
Brain Lipid Dynamics in Amyloid Precursor Protein/Presenilin 1 Mouse Model of Early Alzheimer's Disease by Desorption Electrospray Ionization and Matrix Assisted Laser Desorption Ionization-Mass Spectrometry Imaging Techniques.
Autorzy :
Zhang X; Postdoctoral Innovation Base, Zhuhai Yuanzhi Health Technology Co. Ltd, Hengqin New Area, Zhuhai, Guangdong 519000, China.; College of Pharmacy, Jinan University, Guangzhou, Guangdong 510632, China.
Wu C; College of Pharmacy, Jinan University, Guangzhou, Guangdong 510632, China.
Tan W; College of Biomedicine, Guangdong University of Technology, Higher Education Mega Center, Guangzhou, Guangdong 510006, China.
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Źródło :
Journal of proteome research [J Proteome Res] 2021 May 07; Vol. 20 (5), pp. 2643-2650. Date of Electronic Publication: 2021 Mar 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alzheimer Disease*/diagnostic imaging
Amyloid beta-Protein Precursor*/genetics
Amyloid beta-Peptides/metabolism ; Animals ; Brain/diagnostic imaging ; Brain/metabolism ; Lasers ; Lipids ; Mice ; Mice, Transgenic ; Presenilin-1 ; Spectrometry, Mass, Electrospray Ionization ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Czasopismo naukowe
Tytuł :
Analysis the alteration of systemic inflammation in old and young APP/PS1 mouse.
Autorzy :
Liu L; School of Food Science and Engineering, South China University of Technology, Guangzhou, China. Electronic address: .
Cao J; School of Food Science and Engineering, South China University of Technology, Guangzhou, China. Electronic address: .
Huang C; School of Food Science and Engineering, South China University of Technology, Guangzhou, China.
Yuan E; School of Food Science and Engineering, South China University of Technology, Guangzhou, China.
Ren J; School of Food Science and Engineering, South China University of Technology, Guangzhou, China. Electronic address: .
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Źródło :
Experimental gerontology [Exp Gerontol] 2021 May; Vol. 147, pp. 111274. Date of Electronic Publication: 2021 Feb 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alzheimer Disease*/genetics
Amyloid beta-Protein Precursor*/genetics
Aged ; Amyloid beta-Peptides ; Animals ; Disease Models, Animal ; Humans ; Inflammation ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Presenilin-1/genetics
Czasopismo naukowe
Tytuł :
Multi-target inhibition ability of neohesperidin dictates its neuroprotective activity: Implication in Alzheimer's disease therapeutics.
Autorzy :
Chakraborty S; Amity Institute of Biotechnology, Amity University, Action Area II, Rajarhat, Kolkata 700135, India. Electronic address: .
Rakshit J; Department of Biotechnology, Maulana Abul Kalam Azad University of Technology, West Bengal, NH 12, Haringhata 741249, West Bengal, India.
Bandyopadhyay J; Department of Biotechnology, Maulana Abul Kalam Azad University of Technology, West Bengal, NH 12, Haringhata 741249, West Bengal, India. Electronic address: .
Basu S; Department of Microbiology, University of Calcutta, 35, Ballygunge Circular Road, Kolkata 700019, India. Electronic address: .
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2021 Apr 15; Vol. 176, pp. 315-324. Date of Electronic Publication: 2021 Feb 11.
Typ publikacji :
Journal Article
MeSH Terms :
Amyloid Precursor Protein Secretases*/chemistry
Amyloid Precursor Protein Secretases*/metabolism
Amyloid beta-Peptides*/chemistry
Amyloid beta-Peptides*/metabolism
Amyloid beta-Protein Precursor*/chemistry
Amyloid beta-Protein Precursor*/metabolism
Aspartic Acid Endopeptidases*/chemistry
Aspartic Acid Endopeptidases*/metabolism
Neuroprotective Agents*/chemistry
Neuroprotective Agents*/pharmacology
Peptide Fragments*/chemistry
Peptide Fragments*/metabolism
Alzheimer Disease/*drug therapy
Hesperidin/*analogs & derivatives
Alzheimer Disease/metabolism ; Cell Line, Tumor ; Hesperidin/chemistry ; Hesperidin/pharmacology ; Humans
Czasopismo naukowe
Tytuł :
Amyloid precursor protein binds with TNFRSF21 to induce neural inflammation in Alzheimer's Disease.
Autorzy :
Zhang T; Department of Rehabilitation, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China. Electronic address: .
Yu J; Department of Rehabilitation, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Wang G; Department of Rehabilitation, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Zhang R; Department of Rehabilitation, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
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Źródło :
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences [Eur J Pharm Sci] 2021 Feb 01; Vol. 157, pp. 105598. Date of Electronic Publication: 2020 Oct 16.
Typ publikacji :
Journal Article
MeSH Terms :
Alzheimer Disease*
Amyloid beta-Protein Precursor*/genetics
Amyloid beta-Protein Precursor*/metabolism
Amyloid beta-Peptides/metabolism ; Animals ; Brain/metabolism ; Disease Models, Animal ; Inflammation ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic
Czasopismo naukowe
Tytuł :
Cholesterol-lowering drugs reduce APP processing to Aβ by inducing APP dimerization.
Autorzy :
Langness VF; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093.; Sanford Consortium for Regenerative Medicine, University of California, San Diego, La Jolla, CA 92037.
van der Kant R; Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University, Amsterdam de Boelelaan 1087, 1081 HV Amsterdam, The Netherlands.; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Amsterdam UMC, De Boelelaan 1118, 1081 HZ Amsterdam, The Netherlands.
Das U; Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093.; Sanford Consortium for Regenerative Medicine, University of California, San Diego, La Jolla, CA 92037.
Wang L; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093.; Sanford Consortium for Regenerative Medicine, University of California, San Diego, La Jolla, CA 92037.
Chaves RDS; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093.; Sanford Consortium for Regenerative Medicine, University of California, San Diego, La Jolla, CA 92037.
Goldstein LSB; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093.; Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093.; Sanford Consortium for Regenerative Medicine, University of California, San Diego, La Jolla, CA 92037.
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Źródło :
Molecular biology of the cell [Mol Biol Cell] 2021 Feb 01; Vol. 32 (3), pp. 247-259. Date of Electronic Publication: 2020 Dec 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Amyloid beta-Protein Precursor/*metabolism
Hydroxymethylglutaryl-CoA Reductase Inhibitors/*pharmacology
Neurons/*metabolism
Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Amyloid Precursor Protein Secretases/metabolism ; Amyloid beta-Peptides/metabolism ; Amyloid beta-Peptides/physiology ; Amyloid beta-Protein Precursor/drug effects ; Amyloid beta-Protein Precursor/physiology ; Aspartic Acid Endopeptidases/metabolism ; Cholesterol/metabolism ; Dimerization ; HEK293 Cells ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/metabolism ; Induced Pluripotent Stem Cells/metabolism ; Neurons/drug effects ; Neurons/physiology ; Protein Binding
Czasopismo naukowe
Tytuł :
Trem2 restrains the enhancement of tau accumulation and neurodegeneration by β-amyloid pathology.
Autorzy :
Lee SH; Department of Neuroscience, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Meilandt WJ; Department of Neuroscience, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA. Electronic address: .
Xie L; Department of Biomedical Imaging, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Gandham VD; Department of Biomedical Imaging, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Ngu H; Department of (3)Pathology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Barck KH; Department of Biomedical Imaging, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Rezzonico MG; Department of Bioinformatics and Computational Biology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Imperio J; Department of Neuroscience, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Lalehzadeh G; Department of Neuroscience, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Huntley MA; Department of Bioinformatics and Computational Biology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Stark KL; Department of Neuroscience, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Foreman O; Department of (3)Pathology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Carano RAD; Department of Biomedical Imaging, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Friedman BA; Department of Bioinformatics and Computational Biology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Sheng M; Department of Neuroscience, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Easton A; Department of Neuroscience, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Bohlen CJ; Department of Neuroscience, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Hansen DV; Department of Neuroscience, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA. Electronic address: .
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Źródło :
Neuron [Neuron] 2021 Apr 21; Vol. 109 (8), pp. 1283-1301.e6. Date of Electronic Publication: 2021 Mar 05.
Typ publikacji :
Journal Article
MeSH Terms :
Alzheimer Disease/*metabolism
Amyloid/*metabolism
Amyloid beta-Protein Precursor/*metabolism
Brain/*metabolism
Membrane Glycoproteins/*metabolism
Receptors, Immunologic/*metabolism
tau Proteins/*metabolism
Alzheimer Disease/genetics ; Alzheimer Disease/pathology ; Amyloid beta-Peptides/metabolism ; Amyloid beta-Protein Precursor/genetics ; Animals ; Atrophy/genetics ; Atrophy/metabolism ; Atrophy/pathology ; Brain/pathology ; Disease Models, Animal ; Membrane Glycoproteins/genetics ; Mice ; Mice, Transgenic ; Receptors, Immunologic/genetics ; tau Proteins/genetics
Czasopismo naukowe
Tytuł :
Dietary-challenged mice with Alzheimer-like pathology show increased energy expenditure and reduced adipocyte hypertrophy and steatosis.
Autorzy :
Schreyer S; Department of Neurology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin 10117, Germany.
Berndt N; Institute for Imaging Science and Computational Modelling in Cardiovascular Medicine, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin 13353, Germany.
Eckstein J; Institute of Biochemistry, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin 10117, Germany.
Mülleder M; Core Facility High Throughput Mass Spectrometry, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin 10117, Germany.
Hemmati-Sadeghi S; Department of Neurology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin 10117, Germany.
Klein C; Department of Neurology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin 10117, Germany.
Abuelnor B; Department of Neurology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin 10117, Germany.
Panzel A; Department of Neurology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin 10117, Germany.
Meierhofer D; Max Planck Institute for Molecular Genetics, Berlin 14195, Germany.
Spranger J; Department of Endocrinology and Metabolism, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin 10117, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Berlin, Germany.
Steiner B; Department of Neurology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin 10117, Germany.
Brachs S; Department of Endocrinology and Metabolism, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin 10117, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Berlin, Germany.
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Źródło :
Aging [Aging (Albany NY)] 2021 Apr 16; Vol. 13 (8), pp. 10891-10919. Date of Electronic Publication: 2021 Apr 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adipocytes/*pathology
Alzheimer Disease/*metabolism
Amyloid beta-Protein Precursor/*genetics
Fatty Liver/*diagnosis
Glucose Intolerance/*diagnosis
Alzheimer Disease/genetics ; Alzheimer Disease/pathology ; Amyloid beta-Protein Precursor/metabolism ; Animals ; Brain/pathology ; Diet, High-Fat/adverse effects ; Dietary Sucrose/administration & dosage ; Dietary Sucrose/adverse effects ; Disease Models, Animal ; Energy Metabolism/genetics ; Fatty Liver/etiology ; Fatty Liver/metabolism ; Fatty Liver/pathology ; Female ; Glucose Intolerance/etiology ; Glucose Intolerance/metabolism ; Glucose Intolerance/pathology ; Humans ; Hypertrophy/diagnosis ; Hypertrophy/etiology ; Hypertrophy/metabolism ; Hypertrophy/pathology ; Liver/pathology ; Mice ; Mice, Transgenic ; Severity of Illness Index
Czasopismo naukowe

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