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Tytuł:
Sporadic Amyotrophic Lateral Sclerosis Skeletal Muscle Transcriptome Analysis: A Comprehensive Examination of Differentially Expressed Genes.
Autorzy:
Gascón E; Department of Anatomy, Embryology and Animal Genetics, University of Zaragoza, 50013 Zaragoza, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), 28029 Madrid, Spain.; Agroalimentary Institute of Aragon (IA2), University of Zaragoza, 50013 Zaragoza, Spain.; Institute of Health Research of Aragon (IIS), 50009 Zaragoza, Spain.
Zaragoza P; Department of Anatomy, Embryology and Animal Genetics, University of Zaragoza, 50013 Zaragoza, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), 28029 Madrid, Spain.; Agroalimentary Institute of Aragon (IA2), University of Zaragoza, 50013 Zaragoza, Spain.; Institute of Health Research of Aragon (IIS), 50009 Zaragoza, Spain.
Calvo AC; Department of Anatomy, Embryology and Animal Genetics, University of Zaragoza, 50013 Zaragoza, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), 28029 Madrid, Spain.; Agroalimentary Institute of Aragon (IA2), University of Zaragoza, 50013 Zaragoza, Spain.; Institute of Health Research of Aragon (IIS), 50009 Zaragoza, Spain.
Osta R; Department of Anatomy, Embryology and Animal Genetics, University of Zaragoza, 50013 Zaragoza, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), 28029 Madrid, Spain.; Agroalimentary Institute of Aragon (IA2), University of Zaragoza, 50013 Zaragoza, Spain.; Institute of Health Research of Aragon (IIS), 50009 Zaragoza, Spain.
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Źródło:
Biomolecules [Biomolecules] 2024 Mar 20; Vol. 14 (3). Date of Electronic Publication: 2024 Mar 20.
Typ publikacji:
Review; Journal Article
MeSH Terms:
Amyotrophic Lateral Sclerosis*/genetics
Amyotrophic Lateral Sclerosis*/metabolism
MicroRNAs*/genetics
MicroRNAs*/metabolism
Humans ; Transcriptome/genetics ; Muscle, Skeletal/metabolism ; Biomarkers
SCR Disease Name:
Amyotrophic lateral sclerosis 1
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Ensemble-imbalance-based classification for amyotrophic lateral sclerosis prognostic prediction: identifying short-survival patients at diagnosis.
Autorzy:
Papaiz F; Federal University of Rio Grande Do Norte, Natal, Brazil. .; University of Coimbra, Coimbra, Portugal. .; Federal Institute of Rio Grande Do Norte, Natal, Brazil. .
Dourado MET Jr; Federal University of Rio Grande Do Norte, Natal, Brazil.
de Medeiros Valentim RA; Federal University of Rio Grande Do Norte, Natal, Brazil.
Pinto R; Federal University of Rio Grande Do Norte, Natal, Brazil.; Federal Institute of Rio Grande Do Norte, Natal, Brazil.
de Morais AHF; Federal Institute of Rio Grande Do Norte, Natal, Brazil.
Arrais JP; University of Coimbra, Coimbra, Portugal.
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Źródło:
BMC medical informatics and decision making [BMC Med Inform Decis Mak] 2024 Mar 19; Vol. 24 (1), pp. 80. Date of Electronic Publication: 2024 Mar 19.
Typ publikacji:
Journal Article
MeSH Terms:
Amyotrophic Lateral Sclerosis*/diagnosis
Amyotrophic Lateral Sclerosis*/drug therapy
Humans ; Prognosis ; Machine Learning
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
TBK1, a prioritized drug repurposing target for amyotrophic lateral sclerosis: evidence from druggable genome Mendelian randomization and pharmacological verification in vitro.
Autorzy:
Duan QQ; Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.; Institute of Brain Science and Brain-Inspired Technology, West China Hospital, Sichuan University, Sichuan, Chengdu,, 610041, China.; Rare Disease Center, West China Hospital, Sichuan University, Sichuan, Chengdu, 610041, China.
Wang H; Department of Pathophysiology, West China College of Basic Medical Sciences and Forensic Medicine, Sichuan University, Sichuan, Chengdu, 610041, China.
Su WM; Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.; Institute of Brain Science and Brain-Inspired Technology, West China Hospital, Sichuan University, Sichuan, Chengdu,, 610041, China.; Rare Disease Center, West China Hospital, Sichuan University, Sichuan, Chengdu, 610041, China.
Gu XJ; Mental Health Center, West China Hospital, Sichuan University, Sichuan, Chengdu, 610041, China.
Shen XF; TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, 610072, China.
Jiang Z; Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.; Institute of Brain Science and Brain-Inspired Technology, West China Hospital, Sichuan University, Sichuan, Chengdu,, 610041, China.; Rare Disease Center, West China Hospital, Sichuan University, Sichuan, Chengdu, 610041, China.
Ren YL; Department of Pathophysiology, West China College of Basic Medical Sciences and Forensic Medicine, Sichuan University, Sichuan, Chengdu, 610041, China.
Cao B; Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.; Institute of Brain Science and Brain-Inspired Technology, West China Hospital, Sichuan University, Sichuan, Chengdu,, 610041, China.; Rare Disease Center, West China Hospital, Sichuan University, Sichuan, Chengdu, 610041, China.
Li GB; Key Laboratory of Drug Targeting and Drug Delivery System of Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu, 610041, China.
Wang Y; Department of Pathophysiology, West China College of Basic Medical Sciences and Forensic Medicine, Sichuan University, Sichuan, Chengdu, 610041, China. .
Chen YP; Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China. .; Institute of Brain Science and Brain-Inspired Technology, West China Hospital, Sichuan University, Sichuan, Chengdu,, 610041, China. .; Rare Disease Center, West China Hospital, Sichuan University, Sichuan, Chengdu, 610041, China. .
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Źródło:
BMC medicine [BMC Med] 2024 Mar 05; Vol. 22 (1), pp. 96. Date of Electronic Publication: 2024 Mar 05.
Typ publikacji:
Journal Article
MeSH Terms:
Amyotrophic Lateral Sclerosis*/drug therapy
Amyotrophic Lateral Sclerosis*/genetics
Aminopyridines*
Humans ; Drug Repositioning ; Mendelian Randomization Analysis ; Protein Serine-Threonine Kinases/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
C9ORF72 patient-derived endothelial cells drive blood-brain barrier disruption and contribute to neurotoxicity.
Autorzy:
Aragón-González A; Sheffield Institute for Translational Neuroscience, University of Sheffield, 385 Glossop Road, S10 2HQ, Sheffield, UK. .; Facultad de Medicina, Universidad de Málaga, 29010, Malaga, Spain. .; Center for Gene Therapy, The Abigail Wexner Research Institute, Nationwide Children's Hospital, OH 43205, Columbus, USA. .
Shaw AC; Sheffield Institute for Translational Neuroscience, University of Sheffield, 385 Glossop Road, S10 2HQ, Sheffield, UK.
Kok JR; Sheffield Institute for Translational Neuroscience, University of Sheffield, 385 Glossop Road, S10 2HQ, Sheffield, UK.
Roussel FS; Center for Gene Therapy, The Abigail Wexner Research Institute, Nationwide Children's Hospital, OH 43205, Columbus, USA.
Santos Souza CD; Sheffield Institute for Translational Neuroscience, University of Sheffield, 385 Glossop Road, S10 2HQ, Sheffield, UK.
Granger SM; Sheffield Institute for Translational Neuroscience, University of Sheffield, 385 Glossop Road, S10 2HQ, Sheffield, UK.
Vetter T; Center for Gene Therapy, The Abigail Wexner Research Institute, Nationwide Children's Hospital, OH 43205, Columbus, USA.; Department of Pediatrics, The Ohio State University, Columbus, OH, USA.
de Diego Y; Research Group PAIDI CTS-546, Institute of Biomedical Research of Málaga (IBIMA), 29010, Malaga, Spain.; Department of Cell Biology, Physiology, and Immunology, University of Córdoba, Campus Rabanales, Cordoba, Spain.
Meyer KC; Center for Gene Therapy, The Abigail Wexner Research Institute, Nationwide Children's Hospital, OH 43205, Columbus, USA.; Department of Pediatrics, The Ohio State University, Columbus, OH, USA.
Beal SN; Sheffield Institute for Translational Neuroscience, University of Sheffield, 385 Glossop Road, S10 2HQ, Sheffield, UK.
Shaw PJ; Sheffield Institute for Translational Neuroscience, University of Sheffield, 385 Glossop Road, S10 2HQ, Sheffield, UK.; NIHR Sheffield Biomedical Research Centre, Sheffield Teaching Hospitals NHS Foundation Trust, Glossop Road, Sheffield, UK.
Ferraiuolo L; Sheffield Institute for Translational Neuroscience, University of Sheffield, 385 Glossop Road, S10 2HQ, Sheffield, UK. .
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Źródło:
Fluids and barriers of the CNS [Fluids Barriers CNS] 2024 Apr 11; Vol. 21 (1), pp. 34. Date of Electronic Publication: 2024 Apr 11.
Typ publikacji:
Journal Article
MeSH Terms:
Amyotrophic Lateral Sclerosis*/genetics
Induced Pluripotent Stem Cells*/physiology
Humans ; Blood-Brain Barrier/metabolism ; Endothelial Cells/metabolism ; C9orf72 Protein/genetics ; C9orf72 Protein/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The nuclear import receptor Kapβ2 modifies neurotoxicity mediated by poly(GR) in C9orf72-linked ALS/FTD.
Autorzy:
Cicardi ME; Weinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA, USA.
Kankate V; Weinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA, USA.
Sriramoji S; Weinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA, USA.
Krishnamurthy K; Weinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA, USA.
Markandaiah SS; Weinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA, USA.
Verdone BM; Weinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA, USA.
Girdhar A; Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA, USA.
Nelson A; Weinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA, USA.
Rivas LB; Weinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA, USA.
Boehringer A; Weinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA, USA.
Haeusler AR; Weinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA, USA.
Pasinelli P; Weinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA, USA.
Guo L; Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA, USA. .
Trotti D; Weinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA, USA. .
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Źródło:
Communications biology [Commun Biol] 2024 Mar 28; Vol. 7 (1), pp. 376. Date of Electronic Publication: 2024 Mar 28.
Typ publikacji:
Journal Article
MeSH Terms:
Frontotemporal Dementia*/genetics
Amyotrophic Lateral Sclerosis*/genetics
Amyotrophic Lateral Sclerosis*/metabolism
Humans ; Active Transport, Cell Nucleus ; C9orf72 Protein/genetics ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Receptors, Cytoplasmic and Nuclear/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Exploring SVA Insertion Polymorphisms in Shaping Differential Gene Expressions in the Central Nervous System.
Autorzy:
Hughes LS; Perron Institute for Neurological and Translational Science, Perth, WA 6009, Australia.
Fröhlich A; Perron Institute for Neurological and Translational Science, Perth, WA 6009, Australia.; Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L69 3BX, UK.
Pfaff AL; Perron Institute for Neurological and Translational Science, Perth, WA 6009, Australia.; Centre for Molecular Medicine and Innovative Therapeutics, Murdoch University, Perth, WA 6150, Australia.
Bubb VJ; Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L69 3BX, UK.
Quinn JP; Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L69 3BX, UK.
Kõks S; Perron Institute for Neurological and Translational Science, Perth, WA 6009, Australia.; Centre for Molecular Medicine and Innovative Therapeutics, Murdoch University, Perth, WA 6150, Australia.
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Źródło:
Biomolecules [Biomolecules] 2024 Mar 17; Vol. 14 (3). Date of Electronic Publication: 2024 Mar 17.
Typ publikacji:
Journal Article
MeSH Terms:
Retroelements*
Amyotrophic Lateral Sclerosis*/genetics
Humans ; Minisatellite Repeats ; DNA Transposable Elements ; Central Nervous System ; Gene Expression
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Trimetazidine Improves Mitochondrial Dysfunction in SOD1 Cellular Models of Amyotrophic Lateral Sclerosis through Autophagy Activation.
Autorzy:
Salvatori I; Department of Experimental Medicine, University of Roma 'La Sapienza', 00185 Rome, Italy.; IRCCS, Fondazione Santa Lucia, 00179 Rome, Italy.
Nesci V; IRCCS, Fondazione Santa Lucia, 00179 Rome, Italy.; Department of Systems Medicine, Tor Vergata University of Rome, 00133 Rome, Italy.
Spalloni A; IRCCS, Fondazione Santa Lucia, 00179 Rome, Italy.
Marabitti V; Department of Biology, Tor Vergata University of Rome, 00133 Rome, Italy.
Muzzi M; Department of Science, LIME, University of Roma Tre, 00165 Rome, Italy.
Zenuni H; Unit of Neurology, Fondazione PTV Policlinico Tor Vergata, 00133 Rome, Italy.
Scaricamazza S; IRCCS, Fondazione Santa Lucia, 00179 Rome, Italy.
Rosina M; IRCCS, Fondazione Santa Lucia, 00179 Rome, Italy.; Unit of Neurology, Fondazione PTV Policlinico Tor Vergata, 00133 Rome, Italy.
Fenili G; Department of Movement, Human and Health Sciences, University of Rome 'Foro Italico', 00135 Rome, Italy.
Goglia M; Unit of Neurology, Fondazione PTV Policlinico Tor Vergata, 00133 Rome, Italy.
Boffa L; Unit of Neurology, Fondazione PTV Policlinico Tor Vergata, 00133 Rome, Italy.
Massa R; Unit of Neurology, Fondazione PTV Policlinico Tor Vergata, 00133 Rome, Italy.
Moreno S; Department of Science, LIME, University of Roma Tre, 00165 Rome, Italy.
Mercuri NB; IRCCS, Fondazione Santa Lucia, 00179 Rome, Italy.; Department of Systems Medicine, Tor Vergata University of Rome, 00133 Rome, Italy.; Unit of Neurology, Fondazione PTV Policlinico Tor Vergata, 00133 Rome, Italy.
Nazio F; Department of Biology, Tor Vergata University of Rome, 00133 Rome, Italy.
Longone P; IRCCS, Fondazione Santa Lucia, 00179 Rome, Italy.
Ferri A; IRCCS, Fondazione Santa Lucia, 00179 Rome, Italy.; Institute of Translational Pharmacology (IFT), National Research Council (CNR), 00133 Rome, Italy.
Valle C; IRCCS, Fondazione Santa Lucia, 00179 Rome, Italy.; Institute of Translational Pharmacology (IFT), National Research Council (CNR), 00133 Rome, Italy.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Mar 13; Vol. 25 (6). Date of Electronic Publication: 2024 Mar 13.
Typ publikacji:
Journal Article
MeSH Terms:
Amyotrophic Lateral Sclerosis*/metabolism
Trimetazidine*/pharmacology
Trimetazidine*/therapeutic use
Mitochondrial Diseases*
Mice ; Animals ; Humans ; Superoxide Dismutase-1/metabolism ; Mice, Transgenic ; Leukocytes, Mononuclear/metabolism ; Superoxide Dismutase/metabolism ; Autophagy ; Disease Models, Animal
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Progressive Irreversible Proprioceptive Piezo2 Channelopathy-Induced Lost Forced Peripheral Oscillatory Synchronization to the Hippocampal Oscillator May Explain the Onset of Amyotrophic Lateral Sclerosis Pathomechanism.
Autorzy:
Sonkodi B; Department of Health Sciences and Sport Medicine, Hungarian University of Sports Science, 1123 Budapest, Hungary.; Department of Sports Medicine, Semmelweis University, 1122 Budapest, Hungary.
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Źródło:
Cells [Cells] 2024 Mar 12; Vol. 13 (6). Date of Electronic Publication: 2024 Mar 12.
Typ publikacji:
Journal Article
MeSH Terms:
Amyotrophic Lateral Sclerosis*/metabolism
Channelopathies*
Neurodegenerative Diseases*
Humans ; Syndecan-3 ; Mechanotransduction, Cellular ; Protons ; Proprioception/physiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Novel insights into RAGE signaling pathways during the progression of amyotrophic lateral sclerosis in RAGE-deficient SOD1 G93A mice.
Autorzy:
Nowicka N; Department of Human Physiology and Pathophysiology, Faculty of Medicine, Collegium Medium, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland.
Zglejc-Waszak K; Department of Human Physiology and Pathophysiology, Faculty of Medicine, Collegium Medium, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland.
Juranek J; Department of Human Physiology and Pathophysiology, Faculty of Medicine, Collegium Medium, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland.
Korytko A; Department of Human Physiology and Pathophysiology, Faculty of Medicine, Collegium Medium, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland.
Wąsowicz K; Department of Pathophysiology, Forensic Veterinary Medicine and Administration, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland.
Chmielewska-Krzesińska M; Department of Pathophysiology, Forensic Veterinary Medicine and Administration, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland.
Wojtkiewicz J; Department of Human Physiology and Pathophysiology, Faculty of Medicine, Collegium Medium, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland.
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Źródło:
PloS one [PLoS One] 2024 Mar 08; Vol. 19 (3), pp. e0299567. Date of Electronic Publication: 2024 Mar 08 (Print Publication: 2024).
Typ publikacji:
Journal Article
MeSH Terms:
Amyotrophic Lateral Sclerosis*/genetics
Amyotrophic Lateral Sclerosis*/metabolism
Amyotrophic Lateral Sclerosis*/pathology
Neurodegenerative Diseases*
Superoxide Dismutase-1*/genetics
Superoxide Dismutase-1*/metabolism
Animals ; Humans ; Mice ; Disease Models, Animal ; Disease Progression ; Mice, Transgenic ; Prospective Studies ; Receptor for Advanced Glycation End Products/genetics ; Signal Transduction ; Superoxide Dismutase/genetics ; Superoxide Dismutase/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Structural insights into the modulation Of SOD1 aggregation By a fungal metabolite Phialomustin-B: Therapeutic potential in ALS.
Autorzy:
Unni S; Department of Biophysics, National Institute of Mental Health and Neurosciences, Bengaluru, India.
Kommu P; Department of Biophysics, National Institute of Mental Health and Neurosciences, Bengaluru, India.
Aouti S; Department of Biophysics, National Institute of Mental Health and Neurosciences, Bengaluru, India.
Nalli Y; CSIR-Indian Institute of Integrative Medicine, Natural Product Division, Jammu, India.
Bharath MMS; Department of Clinical Psychopharmacology and Neurotoxicology, National Institute of Mental Health and Neurosciences, Bengaluru, India.
Ali A; CSIR-Indian Institute of Integrative Medicine, Natural Product Division, Jammu, India.; Medicinal & Process Chemistry Division, CSIR-Central Drug Research Institute, Jankipuram Extension, Lucknow, India.
Padmanabhan B; Department of Biophysics, National Institute of Mental Health and Neurosciences, Bengaluru, India.
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Źródło:
PloS one [PLoS One] 2024 Mar 06; Vol. 19 (3), pp. e0298196. Date of Electronic Publication: 2024 Mar 06 (Print Publication: 2024).
Typ publikacji:
Journal Article
MeSH Terms:
Amyotrophic Lateral Sclerosis*/drug therapy
Amyotrophic Lateral Sclerosis*/genetics
Humans ; Superoxide Dismutase-1/genetics ; Cytoskeleton ; Muscular Atrophy
SCR Disease Name:
Amyotrophic lateral sclerosis 1
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Unraveling the Heterogeneity of ALS-A Call to Redefine Patient Stratification for Better Outcomes in Clinical Trials.
Autorzy:
Tzeplaeff L; Department of Neurology, Rechts der Isar Hospital, Technical University of Munich, 81675 München, Germany.
Jürs AV; Translational Neurodegeneration Section 'Albrecht Kossel', Department of Neurology, University Medical Center Rostock, 18057 Rostock, Germany.
Wohnrade C; Department of Neurology, Hannover Medical School, 30625 Hannover, Germany.
Demleitner AF; Department of Neurology, Rechts der Isar Hospital, Technical University of Munich, 81675 München, Germany.
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Źródło:
Cells [Cells] 2024 Mar 05; Vol. 13 (5). Date of Electronic Publication: 2024 Mar 05.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Amyotrophic Lateral Sclerosis*/pathology
Humans ; Treatment Outcome ; Clinical Trials as Topic
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Update on Antioxidant Therapy with Edaravone: Expanding Applications in Neurodegenerative Diseases.
Autorzy:
Yamashita T; Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama 700-8558, Japan.
Abe K; Department of Neurology, National Center of Neurology and Psychiatry, Tokyo 187-8551, Japan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Mar 03; Vol. 25 (5). Date of Electronic Publication: 2024 Mar 03.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Amyotrophic Lateral Sclerosis*/drug therapy
Neurodegenerative Diseases*/drug therapy
Neuroprotective Agents*/pharmacology
Animals ; Female ; Pregnancy ; Antioxidants/therapeutic use ; Antipyrine ; Edaravone/pharmacology ; Edaravone/therapeutic use ; Free Radical Scavengers/pharmacology ; Placenta
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Cerebrospinal fluid and blood exosomes as biomarkers for amyotrophic lateral sclerosis; a systematic review.
Autorzy:
Darabi S; Cellular and Molecular Research Center, Research Institute for Non-communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran.
Ariaei A; Student Research Committee, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Rustamzadeh A; Cellular and Molecular Research Center, Research Institute for Non-communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran. .; Department of Anatomical Sciences, School of Medicine, Iran University of Medical Sciences, Hemmat Highway, next to Milad Tower, Tehran, Iran. .
Afshari D; Department of Neurology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Charkhat Gorgich EA; Department of Anatomy, School of Medicine, Iranshahr University of Medical Sciences, Iranshahr, Iran.
Darabi L; Department of Neurology, Tehran Medical Science Branch, Amir Al Momenin Hospital, Islamic Azad University, Tehran, Iran.
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Źródło:
Diagnostic pathology [Diagn Pathol] 2024 Mar 01; Vol. 19 (1), pp. 47. Date of Electronic Publication: 2024 Mar 01.
Typ publikacji:
Systematic Review; Journal Article; Review
MeSH Terms:
Exosomes*
Amyotrophic Lateral Sclerosis*/diagnosis
Humans ; Superoxide Dismutase-1 ; Biomarkers ; DNA-Binding Proteins ; Disease Progression
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Resting-state fMRI functional connectome of C9orf72 mutation status.
Autorzy:
Stanziano M; Neuroradiology Unit, Foundation IRCCS Neurological Institute Carlo Besta, Milan, Italy.; ALS Centre, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Turin, Italy.
Fedeli D; Neuroradiology Unit, Foundation IRCCS Neurological Institute Carlo Besta, Milan, Italy.
Manera U; ALS Centre, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Turin, Italy.; Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, SC Neurologia 1U, Turin, Italy.
Ferraro S; Neuroradiology Unit, Foundation IRCCS Neurological Institute Carlo Besta, Milan, Italy.; MOE Key Laboratory for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
Medina Carrion JP; Neuroradiology Unit, Foundation IRCCS Neurological Institute Carlo Besta, Milan, Italy.
Palermo S; Neuroradiology Unit, Foundation IRCCS Neurological Institute Carlo Besta, Milan, Italy.
Sciortino P; Neuroradiology Unit, CTO Hospital, AOU Città della Salute e della Scienza di Torino, Turin, Italy.
Cogoni M; Neuroradiology Unit, CTO Hospital, AOU Città della Salute e della Scienza di Torino, Turin, Italy.
Agosta F; Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Neurology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy.
Basaia S; Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Filippi M; Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Neurology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy.; Neurorehabilitation Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Neurophysiology Service, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Grisoli M; Neuroradiology Unit, Foundation IRCCS Neurological Institute Carlo Besta, Milan, Italy.
Valentini MC; Neuroradiology Unit, CTO Hospital, AOU Città della Salute e della Scienza di Torino, Turin, Italy.
De Mattei F; ALS Centre, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Turin, Italy.; Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, SC Neurologia 1U, Turin, Italy.
Canosa A; ALS Centre, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Turin, Italy.; Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, SC Neurologia 1U, Turin, Italy.
Calvo A; ALS Centre, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Turin, Italy.; Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, SC Neurologia 1U, Turin, Italy.
Bruzzone MG; Neuroradiology Unit, Foundation IRCCS Neurological Institute Carlo Besta, Milan, Italy.
Chiò A; ALS Centre, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Turin, Italy.; Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, SC Neurologia 1U, Turin, Italy.; Institute of Cognitive Sciences and Technologies, National Council of Research, Rome, Italy.
Nigri A; Neuroradiology Unit, Foundation IRCCS Neurological Institute Carlo Besta, Milan, Italy.
Moglia C; ALS Centre, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Turin, Italy.; Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, SC Neurologia 1U, Turin, Italy.
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Źródło:
Annals of clinical and translational neurology [Ann Clin Transl Neurol] 2024 Mar; Vol. 11 (3), pp. 686-697. Date of Electronic Publication: 2024 Jan 17.
Typ publikacji:
Journal Article
MeSH Terms:
Amyotrophic Lateral Sclerosis*/diagnostic imaging
Amyotrophic Lateral Sclerosis*/genetics
Amyotrophic Lateral Sclerosis*/pathology
Connectome*
Humans ; Magnetic Resonance Imaging ; C9orf72 Protein/genetics ; DNA Repeat Expansion/genetics ; Proteins/genetics ; Mutation
Czasopismo naukowe
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Tytuł:
New Insights into Oxidative Stress and Inflammatory Response in Neurodegenerative Diseases.
Autorzy:
Scarian E; Cellular Models and Neuroepigenetics Unit, IRCCS Mondino Foundation, Via Mondino 2, 27100 Pavia, Italy.
Viola C; Cellular Models and Neuroepigenetics Unit, IRCCS Mondino Foundation, Via Mondino 2, 27100 Pavia, Italy.; Department of Brain and Behavioral Sciences, University of Pavia, Via Agostino Bassi 21, 27100 Pavia, Italy.
Dragoni F; Department of Biology and Biotechnology 'L. Spallanzani', University of Pavia, Via Adolfo Ferrata, 9, 27100 Pavia, Italy.; Molecular Biology and Transcriptomics Unit, IRCCS Mondino Foundation, Via Mondino 2, 27100 Pavia, Italy.
Di Gerlando R; Department of Biology and Biotechnology 'L. Spallanzani', University of Pavia, Via Adolfo Ferrata, 9, 27100 Pavia, Italy.; Molecular Biology and Transcriptomics Unit, IRCCS Mondino Foundation, Via Mondino 2, 27100 Pavia, Italy.
Rizzo B; Molecular Biology and Transcriptomics Unit, IRCCS Mondino Foundation, Via Mondino 2, 27100 Pavia, Italy.
Diamanti L; Neuroncology Unit, IRCCS Mondino Foundation, Via Mondino 2, 27100 Pavia, Italy.
Gagliardi S; Molecular Biology and Transcriptomics Unit, IRCCS Mondino Foundation, Via Mondino 2, 27100 Pavia, Italy.
Bordoni M; Cellular Models and Neuroepigenetics Unit, IRCCS Mondino Foundation, Via Mondino 2, 27100 Pavia, Italy.
Pansarasa O; Cellular Models and Neuroepigenetics Unit, IRCCS Mondino Foundation, Via Mondino 2, 27100 Pavia, Italy.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 26; Vol. 25 (5). Date of Electronic Publication: 2024 Feb 26.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Neurodegenerative Diseases*/metabolism
Amyotrophic Lateral Sclerosis*/metabolism
Humans ; Oxidative Stress/physiology ; Antioxidants/metabolism ; Inflammation/drug therapy
Czasopismo naukowe
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Tytuł:
Stimulating VAPB-PTPIP51 ER-mitochondria tethering corrects FTD/ALS mutant TDP43 linked Ca and synaptic defects.
Autorzy:
Markovinovic A; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, SE5 9RX, London, UK. .
Martín-Guerrero SM; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, SE5 9RX, London, UK.
Mórotz GM; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, SE5 9RX, London, UK.
Salam S; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, SE5 9RX, London, UK.
Gomez-Suaga P; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, SE5 9RX, London, UK.
Paillusson S; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, SE5 9RX, London, UK.
Greig J; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, SE5 9RX, London, UK.
Lee Y; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, SE5 9RX, London, UK.
Mitchell JC; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, SE5 9RX, London, UK.
Noble W; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, SE5 9RX, London, UK.
Miller CCJ; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, SE5 9RX, London, UK. .
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Źródło:
Acta neuropathologica communications [Acta Neuropathol Commun] 2024 Feb 23; Vol. 12 (1), pp. 32. Date of Electronic Publication: 2024 Feb 23.
Typ publikacji:
Journal Article
MeSH Terms:
Amyotrophic Lateral Sclerosis*/pathology
Frontotemporal Dementia*/genetics
Frontotemporal Dementia*/metabolism
Neurodegenerative Diseases*/metabolism
Vesicular Transport Proteins*/genetics
Humans ; Calcium/metabolism ; Endoplasmic Reticulum/metabolism ; Glycogen Synthase Kinase 3 beta/metabolism ; Mitochondria/metabolism ; Protein Tyrosine Phosphatases/metabolism ; Synapses/pathology ; TDP-43 Proteinopathies/metabolism
SCR Disease Name:
Frontotemporal Dementia With Motor Neuron Disease
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Zebrafish CCNF and FUS Mediate Stress-Specific Motor Responses.
Autorzy:
Aksoy YA; Sydney Medical School, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2006, Australia.; Cancer Diagnosis and Pathology Group, Kolling Institute of Medical Research, Royal North Shore Hospital, St Leonards, NSW 2065, Australia.; Macquarie Medical School, Macquarie University, Sydney, NSW 2109, Australia.
Cole AJ; Centenary Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2006, Australia.
Deng W; School of Biomedical Engineering, University of Technology Sydney, Ultimo, NSW 2007, Australia.
Hesselson D; Centenary Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2006, Australia.
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Źródło:
Cells [Cells] 2024 Feb 21; Vol. 13 (5). Date of Electronic Publication: 2024 Feb 21.
Typ publikacji:
Journal Article
MeSH Terms:
Amyotrophic Lateral Sclerosis*/metabolism
Cyclins*/metabolism
Neurodegenerative Diseases*/metabolism
RNA-Binding Protein FUS*/genetics
RNA-Binding Protein FUS*/metabolism
Zebrafish*/metabolism
Animals ; Humans ; Motor Neurons/pathology ; Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The cycad genotoxin methylazoxymethanol, linked to Guam ALS/PDC, induces transcriptional mutagenesis.
Autorzy:
Verheijen BM; School of Gerontology, University of Southern California, Los Angeles, CA, 90089, USA. .; Department of Neuroscience, Maastricht University, Maastricht, The Netherlands. .
Chung C; School of Gerontology, University of Southern California, Los Angeles, CA, 90089, USA.
Thompson B; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.
Kim H; Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Nakahara A; Department of Pathology, Brain Research Institute, Niigata University, Niigata, Japan.
Anink JJ; Department of Neuropathology, Amsterdam UMC, University of Amsterdam, Amsterdam Neuroscience, Amsterdam, The Netherlands.
Mills JD; Department of Neuropathology, Amsterdam UMC, University of Amsterdam, Amsterdam Neuroscience, Amsterdam, The Netherlands.; Department of Clinical and Experimental Epilepsy, University College London Queen Square Institute of Neurology, London, WC1N 3BG, UK.; Chalfont Centre for Epilepsy, Chalfont St Peter, SL9 0RJ, UK.
Lee JH; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.
Aronica E; Department of Neuropathology, Amsterdam UMC, University of Amsterdam, Amsterdam Neuroscience, Amsterdam, The Netherlands.
Oyanagi K; Division of Neuropathology, Department of Brain Disease Research, Shinshu University School of Medicine, Matsumoto, Nagano, Japan.
Kakita A; Department of Pathology, Brain Research Institute, Niigata University, Niigata, Japan.
Gout JF; Department of Biological Sciences, Mississippi State University, Mississippi State, MS, 39762, USA.
Vermulst M; School of Gerontology, University of Southern California, Los Angeles, CA, 90089, USA.
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Corporate Authors:
NYGC ALS Consortium
Źródło:
Acta neuropathologica communications [Acta Neuropathol Commun] 2024 Feb 21; Vol. 12 (1), pp. 30. Date of Electronic Publication: 2024 Feb 21.
Typ publikacji:
Letter
MeSH Terms:
Mutagens*
Amyotrophic Lateral Sclerosis*/genetics
Methylazoxymethanol Acetate/*analogs & derivatives
Humans ; Guam ; Mutagenesis
Opinia redakcyjna
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Neuregulin-1 and ALS19 (ERBB4): at the crossroads of amyotrophic lateral sclerosis and cancer.
Autorzy:
Adashek JJ; Department of Oncology, The Johns Hopkins Hospital, The Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA. .
Pandya C; Center for Personalized Cancer Therapy and Division of Hematology and Oncology, Department of Medicine, UC San Diego Moores Cancer Center, La Jolla, CA, USA.
Maragakis NJ; Department of Neurology, The Johns Hopkins Hospital, Baltimore, MD, USA.
De P; Cancer Genomics, Avera Cancer Institute, Sioux Falls, SD, USA.
Cohen PR; Department of Dermatology, Davis Medical Center, University of California, Sacramento, CA, USA.; Touro University California College of Osteopathic Medicine, Vallejo, CA, USA.
Kato S; Center for Personalized Cancer Therapy and Division of Hematology and Oncology, Department of Medicine, UC San Diego Moores Cancer Center, La Jolla, CA, USA.
Kurzrock R; WIN Consortium, Paris, France. .; MCW Cancer Center, Milwaukee, WI, USA. .; University of Nebraska, Omaha, NE, USA. .
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Źródło:
BMC medicine [BMC Med] 2024 Feb 19; Vol. 22 (1), pp. 74. Date of Electronic Publication: 2024 Feb 19.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Amyotrophic Lateral Sclerosis*/genetics
Neoplasms*/genetics
Neuregulin-1*/genetics
Neuregulin-1*/metabolism
Receptor, ErbB-4*/genetics
Receptor, ErbB-4*/metabolism
Humans ; Signal Transduction
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Unraveling the Genetic Landscape of Neurological Disorders: Insights into Pathogenesis, Techniques for Variant Identification, and Therapeutic Approaches.
Autorzy:
Firdaus Z; Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA.; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA.
Li X; Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA.; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 15; Vol. 25 (4). Date of Electronic Publication: 2024 Feb 15.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Neurodegenerative Diseases*/genetics
Neurodegenerative Diseases*/therapy
Neurodegenerative Diseases*/pathology
Parkinson Disease*/genetics
Parkinson Disease*/therapy
Parkinson Disease*/pathology
Alzheimer Disease*/pathology
Amyotrophic Lateral Sclerosis*/genetics
Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 1-20 z 67117

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