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Wyszukujesz frazę ""Angiotensin-Converting Enzyme 2"" wg kryterium: Temat


Tytuł :
Repositioning of histamine H 1 receptor antagonist: Doxepin inhibits viropexis of SARS-CoV-2 Spike pseudovirus by blocking ACE2.
Autorzy :
Ge S; School of Pharmacy, Xi'an Jiaotong University, Yanta West Road No.76, Xi'an, Shaanxi, 710061 China.
Wang X; School of Pharmacy, Xi'an Jiaotong University, Yanta West Road No.76, Xi'an, Shaanxi, 710061 China.
Hou Y; School of Pharmacy, Xi'an Jiaotong University, Yanta West Road No.76, Xi'an, Shaanxi, 710061 China.
Lv Y; School of Pharmacy, Xi'an Jiaotong University, Yanta West Road No.76, Xi'an, Shaanxi, 710061 China.
Wang C; School of Pharmacy, Xi'an Jiaotong University, Yanta West Road No.76, Xi'an, Shaanxi, 710061 China.
He H; School of Pharmacy, Xi'an Jiaotong University, Yanta West Road No.76, Xi'an, Shaanxi, 710061 China. Electronic address: .
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Źródło :
European journal of pharmacology [Eur J Pharmacol] 2021 Apr 05; Vol. 896, pp. 173897. Date of Electronic Publication: 2021 Jan 23.
Typ publikacji :
Journal Article
MeSH Terms :
Angiotensin-Converting Enzyme 2*/antagonists & inhibitors
Angiotensin-Converting Enzyme 2*/metabolism
COVID-19*/drug therapy
COVID-19*/metabolism
SARS-CoV-2*/drug effects
SARS-CoV-2*/physiology
Doxepin/*pharmacology
Protein Binding/*drug effects
Virus Internalization/*drug effects
Antiviral Agents/pharmacology ; Drug Repositioning ; HEK293 Cells ; Histamine H1 Antagonists/classification ; Histamine H1 Antagonists/pharmacology ; Humans ; Spike Glycoprotein, Coronavirus/metabolism
Czasopismo naukowe
Tytuł :
Characterization of Critical Determinants of ACE2-SARS CoV-2 RBD Interaction.
Autorzy :
Brown EEF; Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada.
Rezaei R; Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada.
Jamieson TR; Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada.
Dave J; Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada.
Martin NT; Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada.
Singaravelu R; Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada.
Crupi MJF; Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada.
Boulton S; Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada.
Tucker S; Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada.
Duong J; Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada.
Poutou J; Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada.
Pelin A; Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada.
Yasavoli-Sharahi H; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON K1N 6N5, Canada.
Taha Z; Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada.
Arulanandam R; Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada.
Surendran A; Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada.
Ghahremani M; Department of Biology, University of Ottawa, Ottawa, ON K1N 6N5, Canada.
Austin B; Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada.
Matar C; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON K1N 6N5, Canada.
Diallo JS; Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada.
Bell JC; Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada.
Ilkow CS; Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada.
Azad T; Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Feb 25; Vol. 22 (5). Date of Electronic Publication: 2021 Feb 25.
Typ publikacji :
Journal Article
MeSH Terms :
Angiotensin-Converting Enzyme 2/*chemistry
Angiotensin-Converting Enzyme 2/*metabolism
COVID-19/*metabolism
COVID-19/*virology
SARS-CoV-2/*metabolism
Spike Glycoprotein, Coronavirus/*chemistry
Spike Glycoprotein, Coronavirus/*metabolism
Amino Acid Sequence ; Angiotensin-Converting Enzyme 2/genetics ; Antibodies, Neutralizing/immunology ; Antiviral Agents/pharmacology ; Binding Sites ; COVID-19/drug therapy ; COVID-19/immunology ; HEK293 Cells ; Host Microbial Interactions ; Humans ; Models, Molecular ; Mutation ; Protein Binding ; Protein Interaction Domains and Motifs ; Receptors, Virus/chemistry ; Receptors, Virus/metabolism ; SARS-CoV-2/drug effects ; Sequence Alignment
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Determining available strategies for prevention and therapy: Exploring COVID‑19 from the perspective of ACE2 (Review).
Autorzy :
Cai L; The Second Clinical School, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.
Guo X; Medical College of Rehabilitation, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.
Cao Y; The Second Clinical School, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.
Ying P; The Second Clinical School, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.
Hong L; The Second Clinical School, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.
Zhang Y; The Second Clinical School, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.
Yi G; Department of Ophthalmology, The Sixth Affiliated Hospital of Sun‑Yat‑Sen University, Guangzhou, Guangdong 510655, P.R. China.
Fu M; Department of Ophthalmology, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong 510282, P.R. China.
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Źródło :
International journal of molecular medicine [Int J Mol Med] 2021 Apr; Vol. 47 (4), pp. 1. Date of Electronic Publication: 2021 Feb 12.
Typ publikacji :
Journal Article
MeSH Terms :
Angiotensin-Converting Enzyme 2/*physiology
Antiviral Agents/*pharmacology
COVID-19/*prevention & control
COVID-19/*therapy
Host-Pathogen Interactions/*physiology
Angiotensin-Converting Enzyme 2/antagonists & inhibitors ; Angiotensin-Converting Enzyme 2/pharmacology ; COVID-19/virology ; Cardiovascular Diseases/etiology ; Chloroquine/analogs & derivatives ; Chloroquine/pharmacology ; Host-Pathogen Interactions/drug effects ; Humans ; Indoles/pharmacology ; Molecular Targeted Therapy ; SARS-CoV-2/pathogenicity ; Spike Glycoprotein, Coronavirus/metabolism ; Virus Internalization
Czasopismo naukowe
Tytuł :
Gene expression analysis identifies genes associated with SARS-COV-2 receptors, ACE2 and TMPRSS2, in normal human lung tissues.
Autorzy :
Hu RW; Tongji Cancer Research Institute, Tongji Hospital, Tongji Medical College in Huazhong University of Science and Technology, Wuhan, Hubei, China. .
Liu C
Gong JP
Cao ZX
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Źródło :
European review for medical and pharmacological sciences [Eur Rev Med Pharmacol Sci] 2021 Mar; Vol. 25 (5), pp. 2409-2414.
Typ publikacji :
Journal Article
MeSH Terms :
Angiotensin-Converting Enzyme 2/*genetics
COVID-19/*genetics
Receptors, Virus/*genetics
Serine Endopeptidases/*genetics
Angiotensin-Converting Enzyme 2/biosynthesis ; Angiotensin-Converting Enzyme 2/metabolism ; COVID-19/metabolism ; COVID-19/virology ; Correlation of Data ; Gene Expression ; Humans ; Receptors, Virus/biosynthesis ; Receptors, Virus/metabolism ; SARS-CoV-2/isolation & purification ; SARS-CoV-2/metabolism ; Serine Endopeptidases/biosynthesis ; Serine Endopeptidases/metabolism
Czasopismo naukowe
Tytuł :
Angiotensin-Converting-Enzyme 2 and Renin-Angiotensin System Inhibitors in COVID-19: An Update.
Autorzy :
Shukla AK; Molecular and Human Genetics Laboratory, Department of Zoology, University of Lucknow, Lucknow, Uttar Pradesh, India.
Banerjee M; Molecular and Human Genetics Laboratory, Department of Zoology, University of Lucknow, Lucknow, Uttar Pradesh, India. .
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Źródło :
High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension [High Blood Press Cardiovasc Prev] 2021 Mar; Vol. 28 (2), pp. 129-139. Date of Electronic Publication: 2021 Feb 26.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Angiotensin Receptor Antagonists/*therapeutic use
Angiotensin-Converting Enzyme 2/*antagonists & inhibitors
Angiotensin-Converting Enzyme Inhibitors/*therapeutic use
Antiviral Agents/*therapeutic use
COVID-19/*drug therapy
Diabetes Mellitus, Type 2/*drug therapy
Renin-Angiotensin System/*drug effects
SARS-CoV-2/*drug effects
Angiotensin Receptor Antagonists/adverse effects ; Angiotensin-Converting Enzyme 2/metabolism ; Angiotensin-Converting Enzyme Inhibitors/adverse effects ; Animals ; Antihypertensive Agents/therapeutic use ; Antiviral Agents/adverse effects ; Blood Pressure/drug effects ; COVID-19/enzymology ; COVID-19/virology ; COVID-19 Vaccines/therapeutic use ; Diabetes Mellitus, Type 2/enzymology ; Diabetes Mellitus, Type 2/physiopathology ; Host-Pathogen Interactions ; Humans ; Hypertension/drug therapy ; Hypertension/enzymology ; Hypertension/physiopathology ; Patient Safety ; Risk Assessment ; Risk Factors ; SARS-CoV-2/genetics ; SARS-CoV-2/pathogenicity ; Treatment Outcome ; Virus Internalization/drug effects
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Angiotensin-converting enzyme 2 and kidney diseases in the era of coronavirus disease 2019.
Autorzy :
Suh SH; Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.
Ma SK; Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.
Kim SW; Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.
Bae EH; Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.
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Źródło :
The Korean journal of internal medicine [Korean J Intern Med] 2021 Mar; Vol. 36 (2), pp. 247-262. Date of Electronic Publication: 2020 Oct 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Renin-Angiotensin System*/drug effects
Virus Internalization*
Angiotensin-Converting Enzyme 2/*metabolism
COVID-19/*virology
Kidney/*enzymology
Kidney Diseases/*enzymology
Receptors, Virus/*metabolism
SARS-CoV-2/*pathogenicity
Angiotensin Receptor Antagonists/therapeutic use ; Angiotensin-Converting Enzyme 2/antagonists & inhibitors ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Animals ; COVID-19/enzymology ; Host-Pathogen Interactions ; Humans ; Kidney/drug effects ; Kidney/physiopathology ; Kidney Diseases/drug therapy ; Kidney Diseases/physiopathology ; SARS-CoV-2/metabolism
Czasopismo naukowe
Tytuł :
A pressor dose of angiotensin II has no influence on the angiotensin-converting enzyme 2 and other molecules associated with SARS-CoV-2 infection in mice.
Autorzy :
Wang Y; Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
Takeshita H; Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
Yamamoto K; Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
Huang Y; Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
Wang C; Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
Nakajima T; Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
Nozato Y; Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
Fujimoto T; Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
Yokoyama S; Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
Hongyo K; Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
Nakagami F; Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
Akasaka H; Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
Takami Y; Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
Takeya Y; Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
Sugimoto K; Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
Rakugi H; Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
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Źródło :
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2021 Mar; Vol. 35 (3), pp. e21419.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
SARS-CoV-2*
Angiotensin II/*pharmacology
Angiotensin II Type 1 Receptor Blockers/*pharmacology
Angiotensin-Converting Enzyme 2/*metabolism
COVID-19/*metabolism
Losartan/*pharmacology
ADAM17 Protein/genetics ; ADAM17 Protein/metabolism ; Angiotensin II/administration & dosage ; Angiotensin II Type 1 Receptor Blockers/administration & dosage ; Angiotensin-Converting Enzyme 2/genetics ; Animals ; Furin/genetics ; Furin/metabolism ; Gene Expression Regulation, Enzymologic/drug effects ; Losartan/administration & dosage ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Serine Endopeptidases/genetics ; Serine Endopeptidases/metabolism ; Vasoconstrictor Agents/pharmacology
Czasopismo naukowe
Tytuł :
ACE2 mutation might explain lower COVID-19 burden in malaria endemic areas.
Autorzy :
De A; ICMR-National Institute of Malaria Research, New Delhi, 110077, India.
Tiwari A; ICMR-National Institute of Malaria Research, New Delhi, 110077, India.; Kumaun University, Nainital, 263001, Uttarakhand, India.
Dash M; ICMR-National Institute of Malaria Research, New Delhi, 110077, India.; Kumaun University, Nainital, 263001, Uttarakhand, India.
Sinha A; ICMR-National Institute of Malaria Research, New Delhi, 110077, India. .
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Źródło :
Human cell [Hum Cell] 2021 Mar; Vol. 34 (2), pp. 702-705. Date of Electronic Publication: 2021 Jan 25.
Typ publikacji :
Letter
MeSH Terms :
Endemic Diseases*
Mutation*
Receptors, Virus*
SARS-CoV-2*/pathogenicity
Angiotensin-Converting Enzyme 2/*genetics
Angiotensin-Converting Enzyme 2/*physiology
COVID-19/*epidemiology
COVID-19/*virology
Malaria/*epidemiology
Angiotensin-Converting Enzyme 2/metabolism ; COVID-19/prevention & control ; Comorbidity ; Female ; Humans ; Male ; Polymorphism, Single Nucleotide ; Spike Glycoprotein, Coronavirus
Opinia redakcyjna
Tytuł :
Lung and Kidney ACE2 and TMPRSS2 in Renin-Angiotensin System Blocker-Treated Comorbid Diabetic Mice Mimicking Host Factors That Have Been Linked to Severe COVID-19.
Autorzy :
Batchu SN; Keenan Research Centre for Biomedical Science and Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.
Kaur H; Keenan Research Centre for Biomedical Science and Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.
Yerra VG; Keenan Research Centre for Biomedical Science and Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.
Advani SL; Keenan Research Centre for Biomedical Science and Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada .
Kabir MG; Keenan Research Centre for Biomedical Science and Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.
Liu Y; Keenan Research Centre for Biomedical Science and Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.
Klein T; Department of Cardiometabolic Diseases Research, Boehringer Ingelheim Pharma, Biberach, Germany.
Advani A; Keenan Research Centre for Biomedical Science and Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada .
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Źródło :
Diabetes [Diabetes] 2021 Mar; Vol. 70 (3), pp. 759-771. Date of Electronic Publication: 2020 Dec 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Diet, High-Fat*
Angiotensin-Converting Enzyme 2/*genetics
Diabetes Mellitus, Experimental/*metabolism
Kidney/*metabolism
Lung/*metabolism
Serine Endopeptidases/*genetics
Age Factors ; Angiotensin II Type 1 Receptor Blockers/pharmacology ; Angiotensin-Converting Enzyme 2/drug effects ; Angiotensin-Converting Enzyme 2/metabolism ; Angiotensin-Converting Enzyme Inhibitors/pharmacology ; Animals ; COVID-19 ; Immunoblotting ; In Situ Hybridization ; Kidney/drug effects ; Lung/drug effects ; Male ; Mice ; Ramipril/pharmacology ; Receptors, Coronavirus/drug effects ; Receptors, Coronavirus/genetics ; Receptors, Coronavirus/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; SARS-CoV-2 ; Serine Endopeptidases/drug effects ; Serine Endopeptidases/metabolism ; Telmisartan/pharmacology
Czasopismo naukowe
Tytuł :
Neuroinvasion of SARS-CoV-2 in human and mouse brain.
Autorzy :
Song E; Department of Immunobiology, Yale School of Medicine, New Haven, CT.
Zhang C; Department of Genetics, Yale School of Medicine, New Haven, CT.; Department of Neuroscience, Yale School of Medicine, New Haven, CT.
Israelow B; Department of Immunobiology, Yale School of Medicine, New Haven, CT.; Department of Internal Medicine, Section of Infectious Diseases, Yale School of Medicine, New Haven, CT.
Lu-Culligan A; Department of Immunobiology, Yale School of Medicine, New Haven, CT.
Prado AV; Sorbonne Université, INSERM U1127, French National Centre for Scientific Research, Joint Research Unit 7225, Paris Brain Institute, Institut du Cerveau et de la Moelle Épinière, Paris, France.
Skriabine S; Sorbonne Université, INSERM U1127, French National Centre for Scientific Research, Joint Research Unit 7225, Paris Brain Institute, Institut du Cerveau et de la Moelle Épinière, Paris, France.
Lu P; Department of Immunobiology, Yale School of Medicine, New Haven, CT.
Weizman OE; Department of Immunobiology, Yale School of Medicine, New Haven, CT.
Liu F; Department of Immunobiology, Yale School of Medicine, New Haven, CT.; Department of Biomedical Engineering, Yale University, New Haven, CT.
Dai Y; Department of Immunobiology, Yale School of Medicine, New Haven, CT.
Szigeti-Buck K; Department of Comparative Medicine, Yale School of Medicine, New Haven, CT.
Yasumoto Y; Department of Comparative Medicine, Yale School of Medicine, New Haven, CT.
Wang G; Yale Center for Genome Analysis, West Haven, CT.
Castaldi C; Yale Center for Genome Analysis, West Haven, CT.
Heltke J; Yale Center for Genome Analysis, West Haven, CT.
Ng E; Yale Center for Genome Analysis, West Haven, CT.
Wheeler J; Yale Center for Genome Analysis, West Haven, CT.
Alfajaro MM; Department of Immunobiology, Yale School of Medicine, New Haven, CT.; Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT.
Levavasseur E; Sorbonne Université, INSERM U1127, French National Centre for Scientific Research, Joint Research Unit 7225, Paris Brain Institute, Institut du Cerveau et de la Moelle Épinière, Paris, France.
Fontes B; Yale Environmental Health and Safety, Yale University, New Haven, CT.
Ravindra NG; Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT.; Department of Computer Science, Yale University, New Haven, CT.
Van Dijk D; Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT.; Department of Computer Science, Yale University, New Haven, CT.
Mane S; Department of Genetics, Yale School of Medicine, New Haven, CT.; Yale Center for Genome Analysis, West Haven, CT.
Gunel M; Department of Genetics, Yale School of Medicine, New Haven, CT.; Department of Neuroscience, Yale School of Medicine, New Haven, CT.; Department of Neurosurgery, Yale School of Medicine, New Haven, CT.
Ring A; Department of Immunobiology, Yale School of Medicine, New Haven, CT.
Kazmi SAJ; Department of Laboratory Medicine, Geisinger Medical Center, Danville, PA.
Zhang K; Department of Laboratory Medicine, Geisinger Medical Center, Danville, PA.
Wilen CB; Department of Immunobiology, Yale School of Medicine, New Haven, CT.; Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT.
Horvath TL; Department of Comparative Medicine, Yale School of Medicine, New Haven, CT.
Plu I; Sorbonne Université, INSERM U1127, French National Centre for Scientific Research, Joint Research Unit 7225, Paris Brain Institute, Institut du Cerveau et de la Moelle Épinière, Paris, France.; Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Département de Neuropathologie, Paris, France.
Haik S; Sorbonne Université, INSERM U1127, French National Centre for Scientific Research, Joint Research Unit 7225, Paris Brain Institute, Institut du Cerveau et de la Moelle Épinière, Paris, France.; Yale Environmental Health and Safety, Yale University, New Haven, CT.; Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Département de Neuropathologie, Paris, France.; Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Cellule nationale de référence des maladies de Creutzfeldt-Jakob, Paris, France.
Thomas JL; Sorbonne Université, INSERM U1127, French National Centre for Scientific Research, Joint Research Unit 7225, Paris Brain Institute, Institut du Cerveau et de la Moelle Épinière, Paris, France.; Department of Neurology, Yale School of Medicine, New Haven, CT.
Louvi A; Department of Neuroscience, Yale School of Medicine, New Haven, CT.; Department of Neurosurgery, Yale School of Medicine, New Haven, CT.
Farhadian SF; Department of Internal Medicine, Section of Infectious Diseases, Yale School of Medicine, New Haven, CT.; Department of Neurology, Yale School of Medicine, New Haven, CT.
Huttner A; Department of Pathology, Yale School of Medicine, New Haven, CT.
Seilhean D; Sorbonne Université, INSERM U1127, French National Centre for Scientific Research, Joint Research Unit 7225, Paris Brain Institute, Institut du Cerveau et de la Moelle Épinière, Paris, France.; Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Département de Neuropathologie, Paris, France.
Renier N; Sorbonne Université, INSERM U1127, French National Centre for Scientific Research, Joint Research Unit 7225, Paris Brain Institute, Institut du Cerveau et de la Moelle Épinière, Paris, France.
Bilguvar K; Department of Genetics, Yale School of Medicine, New Haven, CT.; Yale Center for Genome Analysis, West Haven, CT.
Iwasaki A; Department of Immunobiology, Yale School of Medicine, New Haven, CT.; Department of Molecular, Cellular, and Developmental Biology, Yale School of Medicine, New Haven, CT.; Howard Hughes Medical Institute, Chevy Chase, MD.
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Źródło :
The Journal of experimental medicine [J Exp Med] 2021 Mar 01; Vol. 218 (3).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Angiotensin-Converting Enzyme 2*/antagonists & inhibitors
Angiotensin-Converting Enzyme 2*/metabolism
COVID-19*/metabolism
COVID-19*/pathology
Cerebral Cortex*/metabolism
Cerebral Cortex*/pathology
Cerebral Cortex*/virology
Neurons*/metabolism
Neurons*/pathology
Neurons*/virology
Antibodies, Blocking/*chemistry
SARS-CoV-2/*metabolism
Animals ; Disease Models, Animal ; Female ; Humans ; Male ; Mice ; Middle Aged ; Organoids/metabolism ; Organoids/pathology ; Organoids/virology
Czasopismo naukowe
Tytuł :
Comparative analysis of ACE2 protein expression in rodent, non-human primate, and human respiratory tract at baseline and after injury: A conundrum for COVID-19 pathogenesis.
Autorzy :
Soni S; Department of Pediatric Newborn Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.
Jiang Y; Department of Pediatric Newborn Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.; Department of Respiratory Medicine, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi, China.
Tesfaigzi Y; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.
Hornick JL; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.
Çataltepe S; Department of Pediatric Newborn Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.
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Źródło :
PloS one [PLoS One] 2021 Feb 24; Vol. 16 (2), pp. e0247510. Date of Electronic Publication: 2021 Feb 24 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Angiotensin-Converting Enzyme 2/*biosynthesis
Angiotensin-Converting Enzyme 2/*genetics
Lung Injury/*enzymology
Age Factors ; Alveolar Epithelial Cells/metabolism ; Angiotensin-Converting Enzyme 2/metabolism ; Animals ; Animals, Newborn ; COVID-19/genetics ; COVID-19/metabolism ; COVID-19/pathology ; Female ; Gene Expression ; Humans ; Lung Injury/metabolism ; Lung Injury/pathology ; Macaca fascicularis ; Male ; Mice ; Mice, Inbred C57BL ; Papio papio ; Respiratory Mucosa/enzymology ; Respiratory Mucosa/metabolism ; Respiratory System/metabolism ; Respiratory System/virology ; SARS-CoV-2/isolation & purification ; Transcriptome
Czasopismo naukowe
Tytuł :
Lack of Evidence of Angiotensin-Converting Enzyme 2 Expression and Replicative Infection by SARS-CoV-2 in Human Endothelial Cells.
Autorzy :
McCracken IR; Centre for Cardiovascular Science (I.R.M., A.H.B.), University of Edinburgh, Little France Crescent, United Kingdom.
Saginc G; National Heart and Lung Institute, National Institute for Health Research Imperial Biomedical Research Centre, Imperial College London, United Kingdom (G.S., A.H., C.P., V.K., G.M.B., M.N., A.M.R.).
He L; Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Sweden (L.H., M.A.-M., C.B.).; Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin Neurological Institute, Key Laboratory of Post-Neuroinjury Neuro-Repair and Regeneration in Central Nervous System, Ministry of Education and Tianjin City, Tianjin, China (L.H.).
Huseynov A; National Heart and Lung Institute, National Institute for Health Research Imperial Biomedical Research Centre, Imperial College London, United Kingdom (G.S., A.H., C.P., V.K., G.M.B., M.N., A.M.R.).
Daniels A; Infection Medicine (A.D., S.J.G., J.G.H.), University of Edinburgh, Little France Crescent, United Kingdom.
Fletcher S; The Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, United Kingdom (S.F., N.M.C., C.T.-B.).
Peghaire C; National Heart and Lung Institute, National Institute for Health Research Imperial Biomedical Research Centre, Imperial College London, United Kingdom (G.S., A.H., C.P., V.K., G.M.B., M.N., A.M.R.).
Kalna V; National Heart and Lung Institute, National Institute for Health Research Imperial Biomedical Research Centre, Imperial College London, United Kingdom (G.S., A.H., C.P., V.K., G.M.B., M.N., A.M.R.).
Andaloussi-Mäe M; Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Sweden (L.H., M.A.-M., C.B.).
Muhl L; Integrated Cardio Metabolic Centre (L.M., U.L., C.B.), Karolinska Institute, Sweden.
Craig NM; The Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, United Kingdom (S.F., N.M.C., C.T.-B.).
Griffiths SJ; Infection Medicine (A.D., S.J.G., J.G.H.), University of Edinburgh, Little France Crescent, United Kingdom.
Haas JG; Infection Medicine (A.D., S.J.G., J.G.H.), University of Edinburgh, Little France Crescent, United Kingdom.
Tait-Burkard C; The Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, United Kingdom (S.F., N.M.C., C.T.-B.).
Lendahl U; Integrated Cardio Metabolic Centre (L.M., U.L., C.B.), Karolinska Institute, Sweden.; Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden (U.L.).
Birdsey GM; National Heart and Lung Institute, National Institute for Health Research Imperial Biomedical Research Centre, Imperial College London, United Kingdom (G.S., A.H., C.P., V.K., G.M.B., M.N., A.M.R.).
Betsholtz C; Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Sweden (L.H., M.A.-M., C.B.).; Integrated Cardio Metabolic Centre (L.M., U.L., C.B.), Karolinska Institute, Sweden.; Department of Medicine Huddinge (C.B.), Karolinska Institute, Sweden.
Noseda M; National Heart and Lung Institute, National Institute for Health Research Imperial Biomedical Research Centre, Imperial College London, United Kingdom (G.S., A.H., C.P., V.K., G.M.B., M.N., A.M.R.).
Baker AH; Centre for Cardiovascular Science (I.R.M., A.H.B.), University of Edinburgh, Little France Crescent, United Kingdom.
Randi AM; National Heart and Lung Institute, National Institute for Health Research Imperial Biomedical Research Centre, Imperial College London, United Kingdom (G.S., A.H., C.P., V.K., G.M.B., M.N., A.M.R.).
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Źródło :
Circulation [Circulation] 2021 Feb 23; Vol. 143 (8), pp. 865-868. Date of Electronic Publication: 2021 Jan 06.
Typ publikacji :
Letter
MeSH Terms :
Virus Replication*
Angiotensin-Converting Enzyme 2/*physiology
Endothelial Cells/*virology
SARS-CoV-2/*physiology
Angiotensin-Converting Enzyme 2/genetics ; Endothelial Cells/enzymology ; Humans
Opinia redakcyjna
Tytuł :
An engineered decoy receptor for SARS-CoV-2 broadly binds protein S sequence variants.
Autorzy :
Chan KK; Orthogonal Biologics, Champaign, IL 61821, USA.
Tan TJC; Department of Biochemistry and Cancer Center at Illinois, University of Illinois, Urbana, IL 61801, USA.
Narayanan KK; Department of Biochemistry and Cancer Center at Illinois, University of Illinois, Urbana, IL 61801, USA.
Procko E; Department of Biochemistry and Cancer Center at Illinois, University of Illinois, Urbana, IL 61801, USA. .
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Źródło :
Science advances [Sci Adv] 2021 Feb 17; Vol. 7 (8). Date of Electronic Publication: 2021 Feb 17 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
COVID-19*/drug therapy
Protein Engineering*
Angiotensin-Converting Enzyme 2/*chemistry
SARS-CoV-2/*chemistry
Angiotensin-Converting Enzyme 2/genetics ; Angiotensin-Converting Enzyme 2/metabolism ; Angiotensin-Converting Enzyme 2/therapeutic use ; Animals ; Cell Line ; Chiroptera ; Humans ; Mutagenesis ; Protein Domains ; SARS-CoV-2/genetics ; SARS-CoV-2/metabolism
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Binding of SARS-CoV-2 to Cell Receptors: A Tale of Molecular Evolution.
Autorzy :
Gómez SA; Instituto de Química, Universidad de Antioquia UdeA, Calle 70 No. 52-21, Medellín, Colombia.
Rojas-Valencia N; Instituto de Química, Universidad de Antioquia UdeA, Calle 70 No. 52-21, Medellín, Colombia.; Escuela de Ciencias y Humanidades, Departamento de Ciencias Básicas, Universidad Eafit, AA, 3300, Medellín, Colombia.
Gómez S; Scuola Normale Superiore, Classe di Scienze, Piazza dei Cavalieri 7, 56126, Pisa, Italy.
Egidi F; Scuola Normale Superiore, Classe di Scienze, Piazza dei Cavalieri 7, 56126, Pisa, Italy.
Cappelli C; Scuola Normale Superiore, Classe di Scienze, Piazza dei Cavalieri 7, 56126, Pisa, Italy.
Restrepo A; Instituto de Química, Universidad de Antioquia UdeA, Calle 70 No. 52-21, Medellín, Colombia.
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Źródło :
Chembiochem : a European journal of chemical biology [Chembiochem] 2021 Feb 15; Vol. 22 (4), pp. 724-732. Date of Electronic Publication: 2020 Nov 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Angiotensin-Converting Enzyme 2/*metabolism
COVID-19/*prevention & control
Receptors, Virus/*metabolism
SARS-CoV-2/*metabolism
Spike Glycoprotein, Coronavirus/*metabolism
Amino Acid Sequence ; Angiotensin-Converting Enzyme 2/chemistry ; Angiotensin-Converting Enzyme 2/genetics ; COVID-19/epidemiology ; COVID-19/virology ; Humans ; Molecular Dynamics Simulation ; Pandemics ; Protein Binding ; Protein Domains ; Receptors, Virus/chemistry ; Receptors, Virus/genetics ; SARS-CoV-2/genetics ; SARS-CoV-2/physiology ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/genetics
Czasopismo naukowe
Tytuł :
The ACE2-binding Interface of SARS-CoV-2 Spike Inherently Deflects Immune Recognition.
Autorzy :
Hattori T; Perlmutter Cancer Center, New York University Langone Health, New York, NY 10016, USA; Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY 10016, USA. Electronic address: .
Koide A; Perlmutter Cancer Center, New York University Langone Health, New York, NY 10016, USA; Department of Medicine, New York University Grossman School of Medicine, New York, NY 10016, USA.
Noval MG; Department of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA.
Panchenko T; Perlmutter Cancer Center, New York University Langone Health, New York, NY 10016, USA.
Romero LA; Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY 10016, USA.
Teng KW; Perlmutter Cancer Center, New York University Langone Health, New York, NY 10016, USA.
Tada T; Department of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA.
Landau NR; Department of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA.
Stapleford KA; Department of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA.
Koide S; Perlmutter Cancer Center, New York University Langone Health, New York, NY 10016, USA; Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY 10016, USA. Electronic address: .
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Źródło :
Journal of molecular biology [J Mol Biol] 2021 Feb 05; Vol. 433 (3), pp. 166748. Date of Electronic Publication: 2020 Dec 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Angiotensin-Converting Enzyme 2/*immunology
Angiotensin-Converting Enzyme 2/*metabolism
Spike Glycoprotein, Coronavirus/*immunology
Spike Glycoprotein, Coronavirus/*metabolism
A549 Cells ; Angiotensin-Converting Enzyme 2/genetics ; Animals ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology ; Binding Sites ; Chlorocebus aethiops ; Epitopes/immunology ; Host-Pathogen Interactions ; Humans ; Immune Sera ; Immunoglobulin G/metabolism ; Mutation ; Spike Glycoprotein, Coronavirus/genetics ; Vero Cells
Czasopismo naukowe
Tytuł :
A single-dose mRNA vaccine provides a long-term protection for hACE2 transgenic mice from SARS-CoV-2.
Autorzy :
Huang Q; CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Ji K; CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China.
Tian S; CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China.
Wang F; CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China.
Huang B; MHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, China CDC, Beijing, China.
Tong Z; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.; Shanxi Academy of Advanced Research and Innovation, Taiyuan, China.
Tan S; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Hao J; Core Facility for Protein Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Wang Q; CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Tan W; MHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, China CDC, Beijing, China. .
Gao GF; University of Chinese Academy of Sciences, Beijing, China. .; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China. .; Chinese Center for Disease Control and Prevention (China CDC), Beijing, China. .
Yan J; CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China. .; University of Chinese Academy of Sciences, Beijing, China. .; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China. .
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Źródło :
Nature communications [Nat Commun] 2021 Feb 03; Vol. 12 (1), pp. 776. Date of Electronic Publication: 2021 Feb 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Angiotensin-Converting Enzyme 2/*immunology
COVID-19/*prevention & control
COVID-19 Vaccines/*administration & dosage
COVID-19 Vaccines/*immunology
SARS-CoV-2/*genetics
SARS-CoV-2/*immunology
Angiotensin-Converting Enzyme 2/genetics ; Angiotensin-Converting Enzyme 2/metabolism ; Animals ; Antibodies, Neutralizing/immunology ; COVID-19/immunology ; COVID-19 Vaccines/genetics ; Cell Line ; Female ; Humans ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Transgenic ; Pandemics/prevention & control ; RNA, Messenger/genetics ; RNA, Messenger/immunology ; RNA, Viral/genetics ; RNA, Viral/immunology ; Spike Glycoprotein, Coronavirus/immunology ; Spike Glycoprotein, Coronavirus/metabolism ; Vaccines, Synthetic/administration & dosage ; Vaccines, Synthetic/genetics ; Vaccines, Synthetic/immunology ; Viral Envelope Proteins/immunology
Czasopismo naukowe
Tytuł :
Screened antipsychotic drugs inhibit SARS-CoV-2 binding with ACE2 in vitro.
Autorzy :
Lu J; School of Pharmacy, Xi'an Jiaotong University, Xi'an 710061, China.
Hou Y; School of Pharmacy, Xi'an Jiaotong University, Xi'an 710061, China.
Ge S; School of Pharmacy, Xi'an Jiaotong University, Xi'an 710061, China.
Wang X; School of Pharmacy, Xi'an Jiaotong University, Xi'an 710061, China.
Wang J; School of Pharmacy, Xi'an Jiaotong University, Xi'an 710061, China.
Hu T; School of Pharmacy, Xi'an Jiaotong University, Xi'an 710061, China.
Lv Y; School of Pharmacy, Xi'an Jiaotong University, Xi'an 710061, China.
He H; School of Pharmacy, Xi'an Jiaotong University, Xi'an 710061, China.
Wang C; School of Pharmacy, Xi'an Jiaotong University, Xi'an 710061, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Feb 01; Vol. 266, pp. 118889. Date of Electronic Publication: 2020 Dec 10.
Typ publikacji :
Journal Article
MeSH Terms :
Angiotensin-Converting Enzyme 2/*metabolism
Antipsychotic Agents/*pharmacology
Antiviral Agents/*pharmacology
Drug Evaluation, Preclinical/*methods
SARS-CoV-2/*drug effects
Angiotensin-Converting Enzyme 2/antagonists & inhibitors ; Angiotensin-Converting Enzyme 2/chemistry ; Antipsychotic Agents/chemistry ; Antipsychotic Agents/metabolism ; Cell Membrane ; Cell Survival/drug effects ; Chromatography, Liquid/methods ; Drug Repositioning ; HEK293 Cells ; Host-Pathogen Interactions/drug effects ; Humans ; Molecular Docking Simulation ; SARS-CoV-2/pathogenicity ; Spike Glycoprotein, Coronavirus/metabolism ; Surface Plasmon Resonance ; Virus Internalization/drug effects
Czasopismo naukowe
Tytuł :
Inhaled corticosteroids downregulate the SARS-CoV-2 receptor ACE2 in COPD through suppression of type I interferon.
Autorzy :
Finney LJ; National Heart and Lung Institute, Imperial College London, London, United Kingdom.
Glanville N; Prokarium, London BioScience Innovation Centre, London, United Kingdom.
Farne H; National Heart and Lung Institute, Imperial College London, London, United Kingdom.
Aniscenko J; National Heart and Lung Institute, Imperial College London, London, United Kingdom.
Fenwick P; National Heart and Lung Institute, Imperial College London, London, United Kingdom.
Kemp SV; National Heart and Lung Institute, Imperial College London, London, United Kingdom; Royal Brompton and Harefield NHS Trust, London, United Kingdom.
Trujillo-Torralbo MB; National Heart and Lung Institute, Imperial College London, London, United Kingdom.
Loo SL; Faculty of Health and Medicine and Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute and University of Newcastle, Newcastle, United Kingdom.
Calderazzo MA; National Heart and Lung Institute, Imperial College London, London, United Kingdom.
Wedzicha JA; National Heart and Lung Institute, Imperial College London, London, United Kingdom.
Mallia P; National Heart and Lung Institute, Imperial College London, London, United Kingdom.
Bartlett NW; Faculty of Health and Medicine and Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute and University of Newcastle, Newcastle, United Kingdom.
Johnston SL; National Heart and Lung Institute, Imperial College London, London, United Kingdom.
Singanayagam A; National Heart and Lung Institute, Imperial College London, London, United Kingdom. Electronic address: .
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Źródło :
The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2021 Feb; Vol. 147 (2), pp. 510-519.e5. Date of Electronic Publication: 2020 Oct 15.
Typ publikacji :
Journal Article
MeSH Terms :
COVID-19*
SARS-CoV-2*
Adrenal Cortex Hormones/*administration & dosage
Angiotensin-Converting Enzyme 2/*antagonists & inhibitors
Interferon Type I/*antagonists & inhibitors
Pulmonary Disease, Chronic Obstructive/*immunology
Administration, Inhalation ; Aged ; Angiotensin-Converting Enzyme 2/genetics ; Angiotensin-Converting Enzyme 2/immunology ; Animals ; Bronchi/cytology ; Cells, Cultured ; Disease Susceptibility ; Down-Regulation/drug effects ; Epithelial Cells/drug effects ; Epithelial Cells/immunology ; Female ; Humans ; Interferon Type I/immunology ; Lung/drug effects ; Lung/immunology ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Middle Aged ; Pulmonary Disease, Chronic Obstructive/genetics ; Receptor, Interferon alpha-beta/genetics ; Serine Endopeptidases/genetics
Czasopismo naukowe
Tytuł :
Angiotensin-converting enzyme as a new immunologic target for the new SARS-CoV-2.
Autorzy :
Hallaj S; Department of Basic Science, Faculty of Medicine, Maragheh University of Medical Sciences, Maragheh, Iran.; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Ghorbani A; Department of Basic Science, Faculty of Medicine, Maragheh University of Medical Sciences, Maragheh, Iran.
Mousavi-Aghdas SA; Department of Basic Science, Faculty of Medicine, Maragheh University of Medical Sciences, Maragheh, Iran.
Mirza-Aghazadeh-Attari M; Department of Basic Science, Faculty of Medicine, Maragheh University of Medical Sciences, Maragheh, Iran.
Sevbitov A; Head of Department of Propaedeutics of Dental Diseases, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
Hashemi V; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Hallaj T; Cellular and Molecular Research Center, Cellular and Molecular Medicine Institute, Urmia University of Medical Sciences, Urmia, Iran.
Jadidi-Niaragh F; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.; Department of Immunology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
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Źródło :
Immunology and cell biology [Immunol Cell Biol] 2021 Feb; Vol. 99 (2), pp. 192-205. Date of Electronic Publication: 2020 Oct 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
COVID-19*/immunology
COVID-19*/pathology
COVID-19*/virology
Virus Internalization*/drug effects
Angiotensin-Converting Enzyme 2/*physiology
SARS-CoV-2/*physiology
Angiotensin Receptor Antagonists/therapeutic use ; Angiotensin-Converting Enzyme 2/antagonists & inhibitors ; Angiotensin-Converting Enzyme 2/therapeutic use ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Animals ; Humans ; Immune System/metabolism ; Immune System/pathology ; Renin-Angiotensin System/drug effects ; Renin-Angiotensin System/physiology ; SARS-CoV-2/drug effects ; SARS-CoV-2/metabolism ; Spike Glycoprotein, Coronavirus/metabolism
Czasopismo naukowe
Tytuł :
A trimeric human angiotensin-converting enzyme 2 as an anti-SARS-CoV-2 agent.
Autorzy :
Xiao T; Division of Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
Lu J; Codex BioSolutions, Inc., Gaithersburg, MD, USA.
Zhang J; Division of Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
Johnson RI; Department of Microbiology, Boston University School of Medicine and National Emerging Infectious Diseases Laboratories, Boston, MA, USA.
McKay LGA; Department of Microbiology, Boston University School of Medicine and National Emerging Infectious Diseases Laboratories, Boston, MA, USA.
Storm N; Department of Microbiology, Boston University School of Medicine and National Emerging Infectious Diseases Laboratories, Boston, MA, USA.
Lavine CL; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Peng H; Division of Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.
Cai Y; Division of Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
Rits-Volloch S; Division of Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.
Lu S; Codex BioSolutions, Inc., Gaithersburg, MD, USA.
Quinlan BD; Department of Immunology and Microbiology, Scripps Research Institute, Jupiter, FL, USA.
Farzan M; Department of Immunology and Microbiology, Scripps Research Institute, Jupiter, FL, USA.
Seaman MS; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Griffiths A; Department of Microbiology, Boston University School of Medicine and National Emerging Infectious Diseases Laboratories, Boston, MA, USA.
Chen B; Division of Molecular Medicine, Boston Children's Hospital, Boston, MA, USA. .; Department of Pediatrics, Harvard Medical School, Boston, MA, USA. .
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Źródło :
Nature structural & molecular biology [Nat Struct Mol Biol] 2021 Feb; Vol. 28 (2), pp. 202-209. Date of Electronic Publication: 2021 Jan 11.
Typ publikacji :
Journal Article
MeSH Terms :
Angiotensin-Converting Enzyme 2/*chemistry
Antiviral Agents/*chemistry
COVID-19/*drug therapy
Angiotensin-Converting Enzyme 2/genetics ; Angiotensin-Converting Enzyme 2/therapeutic use ; Antiviral Agents/therapeutic use ; Cryoelectron Microscopy ; Humans ; Models, Molecular ; Protein Engineering ; Protein Multimerization ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/therapeutic use ; SARS-CoV-2/physiology
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe

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