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Wyszukujesz frazę ""Angiotensin-Converting Enzyme 2"" wg kryterium: Temat


Tytuł:
Determination of soluble angiotensin-converting enzyme 2 in saliva samples and its association with nicotine.
Autorzy:
Bru S; Department of Basic Sciences, Universitat Internacional de Catalunya, Sant Cugat Del Vallès, Barcelona, Spain.
González-Marrón A; Group of Evaluation of Health Determinants and Health Policies, Department of Basic Sciences, Universitat Internacional de Catalunya, Sant Cugat Del Vallès, Barcelona, Spain.
Lidón-Moyano C; Group of Evaluation of Health Determinants and Health Policies, Department of Basic Sciences, Universitat Internacional de Catalunya, Sant Cugat Del Vallès, Barcelona, Spain.
Carballar R; Department of Basic Sciences, Universitat Internacional de Catalunya, Sant Cugat Del Vallès, Barcelona, Spain.
Martínez-Láinez JM; Department of Basic Sciences, Universitat Internacional de Catalunya, Sant Cugat Del Vallès, Barcelona, Spain.
Pérez-Martín H; Group of Evaluation of Health Determinants and Health Policies, Department of Basic Sciences, Universitat Internacional de Catalunya, Sant Cugat Del Vallès, Barcelona, Spain.
Fu M; Tobacco Control Unit, Catalan Institute of Oncology - ICO, WHO Collaborating Centre for Tobacco Control, L'Hospitalet de Llobregat, Barcelona, Spain; Tobacco Control Research Group, Bellvitge Biomedical Research Institute - IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain; School of Medicine and Health Sciences, Universitat de Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain.
Pérez-Ortuño R; Group of Integrative Pharmacology and Systems Neuroscience, Neurosciences Programme, IMIM (Hospital Del Mar Medical Research Institute), Parc de Recerca Biomèdica de Barcelona, Barcelona, Spain.
Ballbè M; Tobacco Control Unit, Catalan Institute of Oncology - ICO, WHO Collaborating Centre for Tobacco Control, L'Hospitalet de Llobregat, Barcelona, Spain; Tobacco Control Research Group, Bellvitge Biomedical Research Institute - IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain; Addictions Unit, Institute of Neurosciences, Hospital Clínic de Barcelona, Barcelona, Spain.
Pascual JA; Department of Medicine and Life Sciences, Universitat Pompeu Fabra, Barcelona Biomedical Research Park, Barcelona, Spain.
Fernández E; Tobacco Control Unit, Catalan Institute of Oncology - ICO, WHO Collaborating Centre for Tobacco Control, L'Hospitalet de Llobregat, Barcelona, Spain; Tobacco Control Research Group, Bellvitge Biomedical Research Institute - IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain; School of Medicine and Health Sciences, Universitat de Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain.
Clotet J; Department of Basic Sciences, Universitat Internacional de Catalunya, Sant Cugat Del Vallès, Barcelona, Spain. Electronic address: .
Martínez-Sánchez JM; Group of Evaluation of Health Determinants and Health Policies, Department of Basic Sciences, Universitat Internacional de Catalunya, Sant Cugat Del Vallès, Barcelona, Spain. Electronic address: .
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Źródło:
Environmental research [Environ Res] 2023 Jan 01; Vol. 216 (Pt 1), pp. 114443. Date of Electronic Publication: 2022 Oct 03.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Angiotensin-Converting Enzyme 2*/analysis
Nicotine*/analysis
Saliva*/chemistry
Humans ; Cotinine/analysis
Czasopismo naukowe
Tytuł:
Activation of Angiotensin-converting Enzyme 2 Protects Against Lipopolysaccharide-induced Glial Activation by Modulating Angiotensin-converting Enzyme 2/Angiotensin (1-7)/Mas Receptor Axis.
Autorzy:
Tiwari P; Division of Pharmacology, CSIR- Central Drug Research Institute, Lucknow-226031, Uttar Pradesh, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad-201002, India.
Tiwari V; Division of Neuroscience and Ageing Biology, CSIR- Central Drug Research Institute, Lucknow-226031, Uttar Pradesh, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad-201002, India.
Gupta S; Division of Neuroscience and Ageing Biology, CSIR- Central Drug Research Institute, Lucknow-226031, Uttar Pradesh, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad-201002, India.
Shukla S; Division of Neuroscience and Ageing Biology, CSIR- Central Drug Research Institute, Lucknow-226031, Uttar Pradesh, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad-201002, India.
Hanif K; Division of Pharmacology, CSIR- Central Drug Research Institute, Lucknow-226031, Uttar Pradesh, India. k_.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad-201002, India. k_.
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Źródło:
Molecular neurobiology [Mol Neurobiol] 2023 Jan; Vol. 60 (1), pp. 203-227. Date of Electronic Publication: 2022 Oct 17.
Typ publikacji:
Journal Article
MeSH Terms:
Angiotensin-Converting Enzyme 2*
Neuroglia*/drug effects
Animals ; Male ; Rats ; Angiotensin I/pharmacology ; Angiotensin II/pharmacology ; Anti-Inflammatory Agents ; Lipopolysaccharides/pharmacology ; Neuroinflammatory Diseases ; Peptide Fragments/pharmacology ; Rats, Sprague-Dawley ; Receptor, Angiotensin, Type 1 ; Receptors, G-Protein-Coupled
Czasopismo naukowe
Tytuł:
Could serum ACE2 levels predict infarct size in acute phase of ST-segment elevation myocardial infarction: a comparative study with classical biomarkers.
Autorzy:
Demirci E; Department of Cardiology, Department of Nuclear Medicine, Department of Biochemistry, Kayseri City Hospital, Kayseri, Turkey. .
Çalapkorur B
Karaçavuş S
Tanrıverdi H
Koçer D
Gençer H
Demirelli S
Şimsek Z
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Źródło:
European review for medical and pharmacological sciences [Eur Rev Med Pharmacol Sci] 2022 Dec; Vol. 26 (24), pp. 9230-9239.
Typ publikacji:
Journal Article
MeSH Terms:
Angiotensin-Converting Enzyme 2*/blood
Angiotensin-Converting Enzyme 2*/metabolism
ST Elevation Myocardial Infarction*/blood
ST Elevation Myocardial Infarction*/diagnosis
ST Elevation Myocardial Infarction*/metabolism
ST Elevation Myocardial Infarction*/therapy
Humans ; Biomarkers/blood ; Biomarkers/metabolism ; Percutaneous Coronary Intervention ; Prognosis ; Treatment Outcome
Czasopismo naukowe
Tytuł:
Omicron: a drug developer's perspective.
Autorzy:
Fang FF; Abimmune Biopharma, Inc., San Diego, CA, USA.
Shi PY; Department of Biochemistry and Molecular Biology, Department of Biochemistry and Molecular Biology, The University of Texas Medical Branch, Galveston, TX, USA.
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Źródło:
Emerging microbes & infections [Emerg Microbes Infect] 2022 Dec; Vol. 11 (1), pp. 208-211.
Typ publikacji:
Journal Article
MeSH Terms:
COVID-19 Drug Treatment*
Angiotensin-Converting Enzyme 2/*metabolism
Drug Design/*methods
Receptors, Virus/*metabolism
SARS-CoV-2/*genetics
Spike Glycoprotein, Coronavirus/*genetics
Angiotensin-Converting Enzyme 2/genetics ; Angiotensin-Converting Enzyme 2/immunology ; Antiviral Agents/chemical synthesis ; Antiviral Agents/therapeutic use ; Binding Sites ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19/transmission ; COVID-19 Vaccines/administration & dosage ; COVID-19 Vaccines/adverse effects ; Humans ; Immune Evasion ; Mutation ; Protein Binding ; Receptors, Virus/genetics ; Receptors, Virus/immunology ; SARS-CoV-2/drug effects ; SARS-CoV-2/immunology ; SARS-CoV-2/pathogenicity ; Spike Glycoprotein, Coronavirus/immunology ; Spike Glycoprotein, Coronavirus/metabolism
SCR Organism:
SARS-CoV-2 variants
Czasopismo naukowe
Tytuł:
Rapid Generation of Circulating and Mucosal Decoy Human ACE2 using mRNA Nanotherapeutics for the Potential Treatment of SARS-CoV-2.
Autorzy:
Kim J; Department of Pharmaceutical Sciences, College of Pharmacy, Robertson Life Sciences Building, Oregon State University, Portland, OR, 97201, USA.
Jozic A; Department of Pharmaceutical Sciences, College of Pharmacy, Robertson Life Sciences Building, Oregon State University, Portland, OR, 97201, USA.
Mukherjee A; Department of Pharmaceutical Sciences, College of Pharmacy, Robertson Life Sciences Building, Oregon State University, Portland, OR, 97201, USA.
Nelson D; Department of Pharmaceutical Sciences, College of Pharmacy, Robertson Life Sciences Building, Oregon State University, Portland, OR, 97201, USA.; High-Throughput Screening Services Laboratory, College of Pharmacy, Oregon State University, Corvallis, OR, 97331, USA.
Chiem K; Disease Prevention and Intervention, and Population Health Programs, Texas Biomedical Research Institute, San Antonio, TX, 78227, USA.
Khan MSR; Disease Prevention and Intervention, and Population Health Programs, Texas Biomedical Research Institute, San Antonio, TX, 78227, USA.
Torrelles JB; Disease Prevention and Intervention, and Population Health Programs, Texas Biomedical Research Institute, San Antonio, TX, 78227, USA.
Martinez-Sobrido L; Disease Prevention and Intervention, and Population Health Programs, Texas Biomedical Research Institute, San Antonio, TX, 78227, USA.
Sahay G; Department of Pharmaceutical Sciences, College of Pharmacy, Robertson Life Sciences Building, Oregon State University, Portland, OR, 97201, USA.; Department of Biomedical Engineering, Robertson Life Sciences Building, Oregon Health & Science University, Portland, OR, 97201, USA.; Department of Ophthalmology, Casey Eye Institute, Oregon Health & Science University, Portland, OR, 97239, USA.
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Źródło:
Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2022 Dec; Vol. 9 (35), pp. e2202556. Date of Electronic Publication: 2022 Oct 10.
Typ publikacji:
Journal Article
MeSH Terms:
Angiotensin-Converting Enzyme 2*/biosynthesis
Angiotensin-Converting Enzyme 2*/blood
Angiotensin-Converting Enzyme 2*/genetics
COVID-19*/therapy
SARS-CoV-2*/enzymology
RNA, Messenger*/administration & dosage
RNA, Messenger*/genetics
Humans
Czasopismo naukowe
Tytuł:
Entropic Overcompensation of the N501Y Mutation on SARS-CoV-2 S Binding to ACE2.
Autorzy:
Vergara NG; Department of Chemical and Biological Engineering, Drexel University, Philadelphia, Pennsylvania19104, United States.
Gatchel M; Department of Biomedical Engineering, University of Delaware, Newark, Delaware19716, United States.
Abrams CF; Department of Chemical and Biological Engineering, Drexel University, Philadelphia, Pennsylvania19104, United States.
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Źródło:
Journal of chemical information and modeling [J Chem Inf Model] 2023 Jan 23; Vol. 63 (2), pp. 633-642. Date of Electronic Publication: 2022 Dec 30.
Typ publikacji:
Journal Article
MeSH Terms:
Angiotensin-Converting Enzyme 2*/genetics
COVID-19*
Humans ; Entropy ; Molecular Dynamics Simulation ; Mutation ; Protein Binding ; SARS-CoV-2/genetics
Czasopismo naukowe
Tytuł:
Angiotensin converting enzyme 2 activation improves allergic rhinitis and suppresses Th2 cytokine release.
Autorzy:
Sun X; Department of Otorhinostomology, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, China.
Xu Y; Department of Otorhinostomology, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, China.
Zhou J; Department of Otorhinostomology, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, China.
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Źródło:
Immunity, inflammation and disease [Immun Inflamm Dis] 2023 Jan; Vol. 11 (1), pp. e763.
Typ publikacji:
Journal Article
MeSH Terms:
Angiotensin-Converting Enzyme 2*/metabolism
Cytokines*/metabolism
Rhinitis, Allergic*/metabolism
Animals ; Humans ; Mice ; Histamine ; Th2 Cells
Czasopismo naukowe
Tytuł:
Association investigations between ACE1 and ACE2 polymorphisms and severity of COVID-19 disease.
Autorzy:
Najafi M; Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran.
Mahdavi MR; Mazandaran University of Medical Sciences, Farah-Abad Road, Sari, Mazandaran, Iran. .
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Źródło:
Molecular genetics and genomics : MGG [Mol Genet Genomics] 2023 Jan; Vol. 298 (1), pp. 27-36. Date of Electronic Publication: 2022 Oct 18.
Typ publikacji:
Journal Article
MeSH Terms:
Angiotensin-Converting Enzyme 2*/genetics
COVID-19*/genetics
Peptidyl-Dipeptidase A*/genetics
Humans ; Case-Control Studies ; Polymorphism, Genetic ; SARS-CoV-2/physiology
Czasopismo naukowe
Tytuł:
Angiotensin converting enzyme 2 level and its significance in COVID-19 and other diseases patients.
Autorzy:
Kamthe DD; Department of Pharmacology, STES's, Smt. Kashibai Navale College of Pharmacy, Savitribai Phule Pune University, Pune, India.
Sarangkar SD; Department of Pharmacology, STES's, Smt. Kashibai Navale College of Pharmacy, Savitribai Phule Pune University, Pune, India.
Dalvi MS; Department of Pharmacology, STES's, Smt. Kashibai Navale College of Pharmacy, Savitribai Phule Pune University, Pune, India.
Gosavi NA; Department of Pharmacology, STES's, Smt. Kashibai Navale College of Pharmacy, Savitribai Phule Pune University, Pune, India.
Nikam VS; Department of Pharmacology, STES's, Smt. Kashibai Navale College of Pharmacy, Savitribai Phule Pune University, Pune, India.
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Źródło:
European journal of clinical investigation [Eur J Clin Invest] 2023 Jan; Vol. 53 (1), pp. e13891. Date of Electronic Publication: 2022 Oct 25.
Typ publikacji:
Meta-Analysis; Journal Article
MeSH Terms:
Angiotensin-Converting Enzyme 2*/metabolism
COVID-19*
Humans ; Renin-Angiotensin System ; SARS-CoV-2/metabolism
Czasopismo naukowe
Tytuł:
Effect of an Inhibitor on the ACE2-Receptor-Binding Domain of SARS-CoV-2.
Autorzy:
Sharma G; Department of Chemistry, Michigan State University, East Lansing, Michigan 48824, United States.
Song LF; Department of Chemistry, Michigan State University, East Lansing, Michigan 48824, United States.
Merz KM; Department of Chemistry, Michigan State University, East Lansing, Michigan 48824, United States.; Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, United States.
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Źródło:
Journal of chemical information and modeling [J Chem Inf Model] 2022 Dec 26; Vol. 62 (24), pp. 6574-6585. Date of Electronic Publication: 2022 Feb 04.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Angiotensin-Converting Enzyme 2*/antagonists & inhibitors
SARS-CoV-2*/drug effects
Humans ; COVID-19 ; Molecular Dynamics Simulation ; Protein Binding
Czasopismo naukowe
Tytuł:
Force-tuned avidity of spike variant-ACE2 interactions viewed on the single-molecule level.
Autorzy:
Zhu R; Department of Experimental Applied Biophysics, Johannes Kepler University Linz, Linz, Austria.
Canena D; Department of Experimental Applied Biophysics, Johannes Kepler University Linz, Linz, Austria.
Sikora M; Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Frankfurt am Main, Germany.; Faculty of Physics, University of Vienna, Vienna, Austria.; Malopolska Centre of Biotechnology, Gronostajowa 7A, 30-387, Kraków, Poland.
Klausberger M; Department of Biotechnology, Institute of Molecular Biotechnology, University of Natural Resources and Life Sciences, Vienna, Vienna, Austria.
Seferovic H; Department of Experimental Applied Biophysics, Johannes Kepler University Linz, Linz, Austria.
Mehdipour AR; Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Frankfurt am Main, Germany.; Center for Molecular Modeling, University of Ghent, Ghent, Belgium.
Hain L; Department of Experimental Applied Biophysics, Johannes Kepler University Linz, Linz, Austria.
Laurent E; Department of Biotechnology, Institute of Molecular Biotechnology, University of Natural Resources and Life Sciences, Vienna, Vienna, Austria.; Core Facility Biomolecular & Cellular Analysis, University of Natural Resources and Life Sciences, Vienna, Vienna, Austria.
Monteil V; Department of Laboratory Medicine, Unit of Clinical Microbiology, Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden.
Wirnsberger G; Apeiron Biologics, Vienna, Austria.
Wieneke R; Institute of Biochemistry, Biocenter, Goethe University Frankfurt, Frankfurt, Germany.
Tampé R; Institute of Biochemistry, Biocenter, Goethe University Frankfurt, Frankfurt, Germany.
Kienzl NF; Department of Applied Genetics and Cell Biology, Institute of Plant Biotechnology and Cell Biology, University of Natural Resources and Life Sciences, Vienna, Vienna, Austria.
Mach L; Department of Applied Genetics and Cell Biology, Institute of Plant Biotechnology and Cell Biology, University of Natural Resources and Life Sciences, Vienna, Vienna, Austria.
Mirazimi A; Department of Laboratory Medicine, Unit of Clinical Microbiology, Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden.; National Veterinary Institute, Uppsala, Sweden.
Oh YJ; Department of Experimental Applied Biophysics, Johannes Kepler University Linz, Linz, Austria.
Penninger JM; Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna, Austria. .; Department of Medical Genetics, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada. .
Hummer G; Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Frankfurt am Main, Germany. .; Institute of Biophysics, Goethe University Frankfurt, Frankfurt am Main, Germany. .
Hinterdorfer P; Department of Experimental Applied Biophysics, Johannes Kepler University Linz, Linz, Austria. .
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Źródło:
Nature communications [Nat Commun] 2022 Dec 24; Vol. 13 (1), pp. 7926. Date of Electronic Publication: 2022 Dec 24.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Angiotensin-Converting Enzyme 2*/metabolism
COVID-19*/virology
SARS-CoV-2*/metabolism
SARS-CoV-2*/physiology
Spike Glycoprotein, Coronavirus*/metabolism
Single Molecule Imaging*
Humans ; Virus Attachment
SCR Organism:
SARS-CoV-2 variants
Czasopismo naukowe
Tytuł:
Control of SARS-CoV-2 infection by MT1-MMP-mediated shedding of ACE2.
Autorzy:
Guo X; School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China.
Cao J; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Cai JP; State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Wu J; School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China.
Huang J; Fujian Provincial Key Laboratory of Innovative Drug Target Research and State Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiamen, China.
Asthana P; School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China.
Wong SKK; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Ye ZW; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Gurung S; School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China.
Zhang Y; School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China.
Wang S; Respiratory Department, Jinhua Guangfu Hospital, Jinhua, China.
Wang Z; Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.
Ge X; Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.
Kwan HY; School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China.
Lyu A; School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China.
Chan KM; Department of Biomedical Sciences, City University of Hong Kong, Hong Kong SAR, China.
Wong N; Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, N.T., Hong Kong SAR, China.
Huang J; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Zhou Z; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Bian ZX; Centre for Chinese Herbal Medicine Drug Development Limited, Hong Kong Baptist University, Hong Kong SAR, China.
Yuan S; State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China. .
Wong HLX; School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China. .
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Źródło:
Nature communications [Nat Commun] 2022 Dec 23; Vol. 13 (1), pp. 7907. Date of Electronic Publication: 2022 Dec 23.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Angiotensin-Converting Enzyme 2*/metabolism
COVID-19*/metabolism
COVID-19*/virology
Matrix Metalloproteinase 14*
SARS-CoV-2*/metabolism
Host-Pathogen Interactions*
Animals ; Humans ; Mice ; Mice, Inbred C57BL ; Peptidyl-Dipeptidase A/metabolism ; Spike Glycoprotein, Coronavirus/metabolism
Czasopismo naukowe
Tytuł:
The Development of Pharmacophore Models for the Search of New Natural Inhibitors of SARS-CoV-2 Spike RBD-ACE2 Binding Interface.
Autorzy:
Semenov VA; A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, Favorsky St. 1, 664033 Irkutsk, Russia.
Krivdin LB; A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, Favorsky St. 1, 664033 Irkutsk, Russia.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2022 Dec 15; Vol. 27 (24). Date of Electronic Publication: 2022 Dec 15.
Typ publikacji:
Journal Article
MeSH Terms:
Angiotensin-Converting Enzyme 2*
COVID-19*
Humans ; SARS-CoV-2 ; Pharmacophore ; Binding Sites ; Protein Binding
Czasopismo naukowe
Tytuł:
ACE2 polymorphisms impact COVID-19 severity in obese patients.
Autorzy:
Jalaleddine N; College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, UAE.
Bouzid A; Sharjah Institute for Medical Research, University of Sharjah, Sharjah, UAE.
Hachim M; College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, UAE.
Sharif-Askari NS; Sharjah Institute for Medical Research, University of Sharjah, Sharjah, UAE.
Mahboub B; Sharjah Institute for Medical Research, University of Sharjah, Sharjah, UAE.; Department of Pulmonary Medicine and Allergy and Sleep Medicine, Rashid Hospital, Dubai Health Authority, Dubai, UAE.
Senok A; College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, UAE.
Halwani R; Sharjah Institute for Medical Research, University of Sharjah, Sharjah, UAE.; Prince Abdullah Ben Khaled Celiac Disease Research Chair, Department of Pediatrics, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia.; Department of Clinical Sciences, College of Medicine, University of Sharjah, Sharjah, UAE.
Hamoudi RA; Sharjah Institute for Medical Research, University of Sharjah, Sharjah, UAE.; Division of Surgery and Interventional Science, UCL, London, UK.
Al Heialy S; College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, UAE. .; Meakins-Christie Laboratories,, Research Institute of the McGill University Health Center, Montreal, QC, Canada. .
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Źródło:
Scientific reports [Sci Rep] 2022 Dec 13; Vol. 12 (1), pp. 21491. Date of Electronic Publication: 2022 Dec 13.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Angiotensin-Converting Enzyme 2*/genetics
COVID-19*/complications
COVID-19*/genetics
Obesity*/complications
Obesity*/genetics
Humans ; Polymorphism, Single Nucleotide ; SARS-CoV-2/metabolism
Czasopismo naukowe
Tytuł:
A broadly neutralizing monoclonal antibody overcomes the mutational landscape of emerging SARS-CoV-2 variants of concern.
Autorzy:
Parray HA; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Narayanan N; Regional Centre for Biotechnology, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Garg S; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Rizvi ZA; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Shrivastava T; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Kushwaha S; National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, India.
Singh J; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Murugavelu P; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Anantharaj A; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Mehdi F; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Raj N; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Singh S; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Dandotiya J; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Lukose A; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Jamwal D; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Kumar S; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Chiranjivi AK; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Dhyani S; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Mishra N; Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India.
Kumar S; ICGEB-Emory Vaccine Center, International Centre for Genetic Engineering and Biotechnology, New Delhi, India.
Jakhar K; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Sonar S; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Panchal AK; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Tripathy MR; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Chowdhury SR; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Ahmed S; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Samal S; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Mani S; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Bhattacharyya S; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Das S; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Sinha S; Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India.
Luthra K; Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India.
Batra G; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Sehgal D; National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, India.
Medigeshi GR; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Sharma C; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Awasthi A; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Garg PK; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Nair DT; Regional Centre for Biotechnology, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Kumar R; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
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Źródło:
PLoS pathogens [PLoS Pathog] 2022 Dec 12; Vol. 18 (12), pp. e1010994. Date of Electronic Publication: 2022 Dec 12 (Print Publication: 2022).
Typ publikacji:
Journal Article
MeSH Terms:
Angiotensin-Converting Enzyme 2*/genetics
COVID-19*
Animals ; Mice ; Humans ; SARS-CoV-2/genetics ; Antibodies, Monoclonal ; Mice, Transgenic ; Spike Glycoprotein, Coronavirus/genetics ; Antibodies, Neutralizing ; Antibodies, Viral/therapeutic use ; Neutralization Tests
SCR Organism:
SARS-CoV-2 variants
Czasopismo naukowe
Tytuł:
SARS-CoV-2 spike protein variant binding affinity to an angiotensin-converting enzyme 2 fusion glycoproteins.
Autorzy:
Matthews AM; Office of Biotechnology Products, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, United States of America.
Biel TG; Office of Biotechnology Products, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, United States of America.
Ortega-Rodriguez U; Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, United States of America.
Falkowski VM; Office of Biotechnology Products, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, United States of America.
Bush X; Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, Rhode Island, United States of America.
Faison T; Office of Biotechnology Products, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, United States of America.
Xie H; Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, United States of America.
Agarabi C; Office of Biotechnology Products, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, United States of America.
Rao VA; Office of Biotechnology Products, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, United States of America.
Ju T; Office of Biotechnology Products, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, United States of America.
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Źródło:
PloS one [PLoS One] 2022 Dec 06; Vol. 17 (12), pp. e0278294. Date of Electronic Publication: 2022 Dec 06 (Print Publication: 2022).
Typ publikacji:
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
MeSH Terms:
Angiotensin-Converting Enzyme 2*
COVID-19*
Animals ; Cricetinae ; Humans ; CHO Cells ; Cricetulus ; Glycoproteins ; SARS-CoV-2/genetics ; Spike Glycoprotein, Coronavirus/genetics
SCR Organism:
SARS-CoV-2 variants
Czasopismo naukowe
Tytuł:
A second functional furin site in the SARS-CoV-2 spike protein.
Autorzy:
Zhang Y; Division of HIV/AIDS and Sex-transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC), Beijing, People's Republic of China.; National Vaccine & Serum Institute, Beijing, People's Republic of China.
Zhang L; Division of HIV/AIDS and Sex-transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC), Beijing, People's Republic of China.
Wu J; Division of HIV/AIDS and Sex-transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC), Beijing, People's Republic of China.
Yu Y; Division of HIV/AIDS and Sex-transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC), Beijing, People's Republic of China.
Liu S; Division of HIV/AIDS and Sex-transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC), Beijing, People's Republic of China.
Li T; Division of HIV/AIDS and Sex-transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC), Beijing, People's Republic of China.
Li Q; Division of HIV/AIDS and Sex-transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC), Beijing, People's Republic of China.
Ding R; Division of HIV/AIDS and Sex-transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC), Beijing, People's Republic of China.
Wang H; Division of HIV/AIDS and Sex-transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC), Beijing, People's Republic of China.
Nie J; Division of HIV/AIDS and Sex-transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC), Beijing, People's Republic of China.
Cui Z; Division of HIV/AIDS and Sex-transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC), Beijing, People's Republic of China.
Wang Y; National Vaccine & Serum Institute, Beijing, People's Republic of China.
Huang W; Division of HIV/AIDS and Sex-transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC), Beijing, People's Republic of China.
Wang Y; Division of HIV/AIDS and Sex-transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC), Beijing, People's Republic of China.; Lead Contact.
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Źródło:
Emerging microbes & infections [Emerg Microbes Infect] 2022 Dec; Vol. 11 (1), pp. 182-194.
Typ publikacji:
Journal Article
MeSH Terms:
Angiotensin-Converting Enzyme 2/*metabolism
Cathepsin L/*metabolism
Furin/*metabolism
SARS-CoV-2/*genetics
Serine Endopeptidases/*metabolism
Spike Glycoprotein, Coronavirus/*genetics
Amino Acid Sequence ; Angiotensin-Converting Enzyme 2/genetics ; Animals ; Cathepsin L/genetics ; Cell Fusion ; Chiroptera ; Furin/genetics ; Gene Expression ; HEK293 Cells ; Humans ; Mice ; Mice, Transgenic ; Mutation ; Receptors, Virus/genetics ; Receptors, Virus/metabolism ; SARS-CoV-2/growth & development ; SARS-CoV-2/metabolism ; SARS-CoV-2/pathogenicity ; Serine Endopeptidases/genetics ; Spike Glycoprotein, Coronavirus/metabolism ; Vermilingua
Czasopismo naukowe
Tytuł:
Advances in Targeting ACE2 for Developing COVID-19 Therapeutics.
Autorzy:
Suvarnapathaki S; Biomedical Engineering and Biotechnology Program, University of Massachusetts Lowell, One University Avenue, Lowell, MA, 01854, USA.; Department of Chemical Engineering, University of Massachusetts Lowell, One University Avenue, Lowell, MA, 01854, USA.
Chauhan D; Department of Chemical Engineering, University of Massachusetts Lowell, One University Avenue, Lowell, MA, 01854, USA.
Nguyen A; Department of Chemical Engineering, University of Massachusetts Lowell, One University Avenue, Lowell, MA, 01854, USA.
Ramalingam M; Institute of Tissue Regeneration Engineering, Dankook University, Cheonan, 330-714, South Korea.; Department of Nanobiomedical Science, BK21 NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan, 330-714, South Korea.; Mechanobiology Dental Medicine Research Center, Dankook University, Cheonan, 31116, Republic of Korea.; School of Basic Medical Sciences, Chengdu University, Chengdu, 610106, China.
Camci-Unal G; Department of Chemical Engineering, University of Massachusetts Lowell, One University Avenue, Lowell, MA, 01854, USA. Gulden_.; Department of Surgery, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA, 01605, USA. Gulden_.
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Źródło:
Annals of biomedical engineering [Ann Biomed Eng] 2022 Dec; Vol. 50 (12), pp. 1734-1749. Date of Electronic Publication: 2022 Oct 19.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Angiotensin-Converting Enzyme 2*/antagonists & inhibitors
COVID-19*
Virus Internalization*/drug effects
Humans ; SARS-CoV-2/metabolism ; COVID-19 Drug Treatment
Czasopismo naukowe
Tytuł:
Computational prediction of the effect of mutations in the receptor-binding domain on the interaction between SARS-CoV-2 and human ACE2.
Autorzy:
Celik I; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Erciyes University, Kayseri, 38039, Turkey. .
Khan A; Department of Bioinformatics and Biological Statistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China.
Dwivany FM; School of Life Sciences and Technology, Institut Teknologi Bandung, Bandung, West Java, 40132, Indonesia.
Fatimawali; Pharmacy Study Program, Faculty of Mathematics and Natural Sciences, Sam Ratulangi University, Manado, North Sulawesi, 95115, Indonesia.
Wei DQ; Department of Bioinformatics and Biological Statistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China.; State Key Laboratory of Microbial Metabolism, Shanghai-Islamabad-Belgrade Joint Innovation Center On Antibacterial Resistances, Joint Laboratory of International Cooperation in Metabolic and Developmental Sciences, Shanghai Jiao Tong University, Ministry of Education and School of Life Sciences and Biotechnology, Shanghai, 200030, People's Republic of China.; Peng Cheng Laboratory, Vanke Cloud City Phase I Building 8, Xili Street, Nashan District, Shenzhen, Guangdong, 518055, People's Republic of China.
Tallei TE; Department of Biology, Faculty of Mathematics and Natural Sciences, Sam Ratulangi University, Manado, North Sulawesi, 95115, Indonesia. trina_.
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Źródło:
Molecular diversity [Mol Divers] 2022 Dec; Vol. 26 (6), pp. 3309-3324. Date of Electronic Publication: 2022 Feb 09.
Typ publikacji:
Journal Article
MeSH Terms:
Angiotensin-Converting Enzyme 2*
COVID-19*
Humans ; SARS-CoV-2/genetics ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/metabolism ; Peptidyl-Dipeptidase A/metabolism ; Protein Domains ; Protein Binding ; Mutation ; Molecular Dynamics Simulation
SCR Organism:
SARS-CoV-2 variants
Czasopismo naukowe
Tytuł:
A peptide array pipeline for the development of Spike-ACE2 interaction inhibitors.
Autorzy:
Chopra A; Institute of Biochemistry, Carleton University, Ottawa, ON, Canada; Department of Biology, Carleton University, Ottawa, ON, Canada.
Shukri AH; Institute of Biochemistry, Carleton University, Ottawa, ON, Canada; Department of Biology, Carleton University, Ottawa, ON, Canada.
Adhikary H; Institute of Biochemistry, Carleton University, Ottawa, ON, Canada; Department of Biology, Carleton University, Ottawa, ON, Canada.
Lukinović V; Institute of Biochemistry, Carleton University, Ottawa, ON, Canada; Department of Biology, Carleton University, Ottawa, ON, Canada.
Hoekstra M; Institute of Biochemistry, Carleton University, Ottawa, ON, Canada; Department of Biology, Carleton University, Ottawa, ON, Canada.
Cowpland M; NuvoBio Corporation, 150 Isabella Street, Suite 150, Ottawa, ON, K1S 1V7, Canada.
Biggar KK; Institute of Biochemistry, Carleton University, Ottawa, ON, Canada; Department of Biology, Carleton University, Ottawa, ON, Canada. Electronic address: .
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Źródło:
Peptides [Peptides] 2022 Dec; Vol. 158, pp. 170898. Date of Electronic Publication: 2022 Oct 21.
Typ publikacji:
Journal Article
MeSH Terms:
Angiotensin-Converting Enzyme 2*
COVID-19 Drug Treatment*
Humans ; SARS-CoV-2 ; Protein Binding ; Peptides/pharmacology ; Peptides/metabolism
Czasopismo naukowe

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