Individuals between the ages of seventeen and forty-five are most at risk for ankylosing spondylitis, as are individuals whose family members have the disease. The American College of Rheumatology reports that, as of 2012, men are two to three times more likely to develop the disease than women are. Other risk factors include having the HLA-B27 gene and having inflammatory bowel disease, ulcerative colitis, or Crohn's disease.
Salem Press Encyclopedia of Health, 2019. 2p.