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Wyszukujesz frazę ""Antibodies"" wg kryterium: Temat


Starter badań:

Tytuł:
Development and Characterization of Phage Display-Derived Monoclonal Antibodies to the S2 Domain of Spike Proteins of Wild-Type SARS-CoV-2 and Multiple Variants.
Autorzy:
Kim JW; Department of Applied Chemistry, Kookmin University, Seoul 02707, Republic of Korea.
Cho AH; Biopharmaceutical Chemistry Major, School of Applied Chemistry, Kookmin University, Seoul 02707, Republic of Korea.
Shin HG; Biopharmaceutical Chemistry Major, School of Applied Chemistry, Kookmin University, Seoul 02707, Republic of Korea.
Jang SH; Department of Applied Chemistry, Kookmin University, Seoul 02707, Republic of Korea.
Cho SY; Biopharmaceutical Chemistry Major, School of Applied Chemistry, Kookmin University, Seoul 02707, Republic of Korea.
Lee YR; Biopharmaceutical Chemistry Major, School of Applied Chemistry, Kookmin University, Seoul 02707, Republic of Korea.
Lee S; Department of Applied Chemistry, Kookmin University, Seoul 02707, Republic of Korea.; Biopharmaceutical Chemistry Major, School of Applied Chemistry, Kookmin University, Seoul 02707, Republic of Korea.; Antibody Research Institute, Kookmin University, Seoul 02707, Republic of Korea.
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Źródło:
Viruses [Viruses] 2023 Jan 06; Vol. 15 (1). Date of Electronic Publication: 2023 Jan 06.
Typ publikacji:
Journal Article
MeSH Terms:
Antibodies, Monoclonal*/genetics
Bacteriophages*
SARS-CoV-2*/genetics
Single-Chain Antibodies*/genetics
Humans ; Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19 ; Spike Glycoprotein, Coronavirus
SCR Organism:
SARS-CoV-2 variants
Czasopismo naukowe
Tytuł:
Neutralization Epitopes in Trimer and Pentamer Complexes Recognized by Potent Cytomegalovirus-Neutralizing Human Monoclonal Antibodies.
Autorzy:
Ai Y; Department of Cell Biology, College of Life Science and Technology, Jinan Universitygrid.258164.c, Guangzhou, China.; Institute of Biomedicine, Jinan Universitygrid.258164.c, Guangzhou, China.
Wu C; Department of Cell Biology, College of Life Science and Technology, Jinan Universitygrid.258164.c, Guangzhou, China.; Trinomab Biotech Co., Ltd., Zhuhai, China.
Zhang M; Department of Cell Biology, College of Life Science and Technology, Jinan Universitygrid.258164.c, Guangzhou, China.; Institute of Biomedicine, Jinan Universitygrid.258164.c, Guangzhou, China.
Jaijyan DK; Department of Microbiology and Molecular Genetics, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA.
Liu T; Department of Cell Biology, College of Life Science and Technology, Jinan Universitygrid.258164.c, Guangzhou, China.; Trinomab Biotech Co., Ltd., Zhuhai, China.
Zan L; Department of Cell Biology, College of Life Science and Technology, Jinan Universitygrid.258164.c, Guangzhou, China.; Institute of Biomedicine, Jinan Universitygrid.258164.c, Guangzhou, China.
Li N; Department of Cell Biology, College of Life Science and Technology, Jinan Universitygrid.258164.c, Guangzhou, China.; Guangdong Provincial Key Laboratory of Bioengineering Medicine, Guangzhou, China.
Yu W; Department of Cell Biology, College of Life Science and Technology, Jinan Universitygrid.258164.c, Guangzhou, China.; Institute of Biomedicine, Jinan Universitygrid.258164.c, Guangzhou, China.
Wang Y; Department of Cell Biology, College of Life Science and Technology, Jinan Universitygrid.258164.c, Guangzhou, China.; Trinomab Biotech Co., Ltd., Zhuhai, China.
Yuan X; Department of Cell Biology, College of Life Science and Technology, Jinan Universitygrid.258164.c, Guangzhou, China.; Trinomab Biotech Co., Ltd., Zhuhai, China.
Li C; Department of Cell Biology, College of Life Science and Technology, Jinan Universitygrid.258164.c, Guangzhou, China.; Trinomab Biotech Co., Ltd., Zhuhai, China.
Zheng W; Trinomab Biotech Co., Ltd., Zhuhai, China.
Zhu H; Department of Microbiology and Molecular Genetics, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA.
Liao HX; Department of Cell Biology, College of Life Science and Technology, Jinan Universitygrid.258164.c, Guangzhou, China.; Trinomab Biotech Co., Ltd., Zhuhai, China.; Institute of Biomedicine, Jinan Universitygrid.258164.c, Guangzhou, China.
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Źródło:
Microbiology spectrum [Microbiol Spectr] 2022 Dec 21; Vol. 10 (6), pp. e0139322. Date of Electronic Publication: 2022 Nov 07.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antibodies, Neutralizing*
Cytomegalovirus Infections*
Infant, Newborn ; Humans ; Cytomegalovirus ; Viral Envelope Proteins/metabolism ; Membrane Glycoproteins ; Epitopes ; Antibodies, Viral ; Antibodies, Monoclonal
Czasopismo naukowe
Tytuł:
Therapeutic applications of nanobodies against SARS-CoV-2 and other viral infections: Current update.
Autorzy:
Bhattacharya M; Department of Zoology, Fakir Mohan University, Vyasa Vihar, Balasore 756020, Odisha, India.
Chatterjee S; Institute for Skeletal Aging & Orthopaedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon-si 24252, Gangwon-do, Republic of Korea.
Lee SS; Institute for Skeletal Aging & Orthopaedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon-si 24252, Gangwon-do, Republic of Korea.
Chakraborty C; Department of Biotechnology, School of Life Science and Biotechnology, Adamas University, Kolkata, West Bengal 700126, India. Electronic address: .
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Źródło:
International journal of biological macromolecules [Int J Biol Macromol] 2023 Feb 28; Vol. 229, pp. 70-80. Date of Electronic Publication: 2022 Dec 28.
Typ publikacji:
Journal Article; Review
MeSH Terms:
COVID-19*/therapy
Single-Domain Antibodies*/therapeutic use
Virus Diseases*
Humans ; SARS-CoV-2 ; Pandemics ; COVID-19 Serotherapy ; Antibodies, Monoclonal ; Antibodies, Viral/therapeutic use ; Antibodies, Neutralizing/therapeutic use
Czasopismo naukowe
Tytuł:
Development of a rapid image-based high-content imaging screening assay to evaluate therapeutic antibodies against the monkeypox virus.
Autorzy:
Kota KP; Tonix Pharmaceuticals Inc, Frederick, MD, USA.
Ziółkowska NE; Tonix Pharmaceuticals Inc, Frederick, MD, USA.
Wei J; Tonix Pharmaceuticals Inc, Frederick, MD, USA.
Peng J; Tonix Pharmaceuticals Inc, Frederick, MD, USA.
Ordonez D; Tonix Pharmaceuticals Inc, Frederick, MD, USA.
Raney C; Tonix Pharmaceuticals Inc, Frederick, MD, USA.
Prigge J; Bioqual Inc., Rockville, MD, USA.
Hooper JW; United States Army Medical Institute of Infectious Diseases, Frederick, MD, USA.
Awasthi M; Tonix Pharmaceuticals Inc, Frederick, MD, USA.
Goebel SJ; Tonix Pharmaceuticals Inc, Frederick, MD, USA.
Zabel BA; Curia Global Inc., Albany, NY, USA.
Nasar F; Tonix Pharmaceuticals Inc, Frederick, MD, USA.
Lederman S; Tonix Pharmaceuticals Inc, Frederick, MD, USA.
Bavari S; Tonix Pharmaceuticals Inc, Frederick, MD, USA. Electronic address: .
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Źródło:
Antiviral research [Antiviral Res] 2023 Feb; Vol. 210, pp. 105513. Date of Electronic Publication: 2022 Dec 30.
Typ publikacji:
Journal Article
MeSH Terms:
Monkeypox virus*
Antibodies, Viral*
Antibodies, Neutralizing ; Vaccinia virus/genetics ; Viral Proteins ; Antibodies, Monoclonal/pharmacology ; Neutralization Tests
Czasopismo naukowe
Tytuł:
A Multivalent and Thermostable Nanobody Neutralizing SARS-CoV-2 Omicron (B.1.1.529).
Autorzy:
Lu Y; One Health Center of Excellence for Research and Training, School of Public Health, Sun Yat-Sen University, Guangzhou, People's Republic of China.; National Medical Products Administration Key Laboratory for Quality Monitoring and Evaluation of Vaccines and Biological Products, Guangzhou, People's Republic of China.; Key Laboratory of Tropical Diseases Control, Sun Yat-Sen University, Ministry of Education, Guangzhou, People's Republic of China.; Research Institute of Sun Yat-Sen University in Shenzhen, Shenzhen, People's Republic of China.; Hainan Key Novel Thinktank 'Hainan Medical University 'One Health' Research Center', Haikou, People's Republic of China.
Li Q; One Health Center of Excellence for Research and Training, School of Public Health, Sun Yat-Sen University, Guangzhou, People's Republic of China.; National Medical Products Administration Key Laboratory for Quality Monitoring and Evaluation of Vaccines and Biological Products, Guangzhou, People's Republic of China.; Key Laboratory of Tropical Diseases Control, Sun Yat-Sen University, Ministry of Education, Guangzhou, People's Republic of China.; Research Institute of Sun Yat-Sen University in Shenzhen, Shenzhen, People's Republic of China.; Hainan Key Novel Thinktank 'Hainan Medical University 'One Health' Research Center', Haikou, People's Republic of China.
Fan H; College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, People's Republic of China.
Liao C; One Health Center of Excellence for Research and Training, School of Public Health, Sun Yat-Sen University, Guangzhou, People's Republic of China.; National Medical Products Administration Key Laboratory for Quality Monitoring and Evaluation of Vaccines and Biological Products, Guangzhou, People's Republic of China.; Key Laboratory of Tropical Diseases Control, Sun Yat-Sen University, Ministry of Education, Guangzhou, People's Republic of China.; Research Institute of Sun Yat-Sen University in Shenzhen, Shenzhen, People's Republic of China.; Hainan Key Novel Thinktank 'Hainan Medical University 'One Health' Research Center', Haikou, People's Republic of China.
Zhang J; One Health Center of Excellence for Research and Training, School of Public Health, Sun Yat-Sen University, Guangzhou, People's Republic of China.; National Medical Products Administration Key Laboratory for Quality Monitoring and Evaluation of Vaccines and Biological Products, Guangzhou, People's Republic of China.; Key Laboratory of Tropical Diseases Control, Sun Yat-Sen University, Ministry of Education, Guangzhou, People's Republic of China.; Research Institute of Sun Yat-Sen University in Shenzhen, Shenzhen, People's Republic of China.; Hainan Key Novel Thinktank 'Hainan Medical University 'One Health' Research Center', Haikou, People's Republic of China.
Hu H; One Health Center of Excellence for Research and Training, School of Public Health, Sun Yat-Sen University, Guangzhou, People's Republic of China.; National Medical Products Administration Key Laboratory for Quality Monitoring and Evaluation of Vaccines and Biological Products, Guangzhou, People's Republic of China.; Key Laboratory of Tropical Diseases Control, Sun Yat-Sen University, Ministry of Education, Guangzhou, People's Republic of China.; Research Institute of Sun Yat-Sen University in Shenzhen, Shenzhen, People's Republic of China.; Hainan Key Novel Thinktank 'Hainan Medical University 'One Health' Research Center', Haikou, People's Republic of China.
Yi H; One Health Center of Excellence for Research and Training, School of Public Health, Sun Yat-Sen University, Guangzhou, People's Republic of China.; National Medical Products Administration Key Laboratory for Quality Monitoring and Evaluation of Vaccines and Biological Products, Guangzhou, People's Republic of China.; Key Laboratory of Tropical Diseases Control, Sun Yat-Sen University, Ministry of Education, Guangzhou, People's Republic of China.; Research Institute of Sun Yat-Sen University in Shenzhen, Shenzhen, People's Republic of China.; Hainan Key Novel Thinktank 'Hainan Medical University 'One Health' Research Center', Haikou, People's Republic of China.
Peng Y; One Health Center of Excellence for Research and Training, School of Public Health, Sun Yat-Sen University, Guangzhou, People's Republic of China.; National Medical Products Administration Key Laboratory for Quality Monitoring and Evaluation of Vaccines and Biological Products, Guangzhou, People's Republic of China.; Key Laboratory of Tropical Diseases Control, Sun Yat-Sen University, Ministry of Education, Guangzhou, People's Republic of China.; Research Institute of Sun Yat-Sen University in Shenzhen, Shenzhen, People's Republic of China.; Hainan Key Novel Thinktank 'Hainan Medical University 'One Health' Research Center', Haikou, People's Republic of China.
Lu J; One Health Center of Excellence for Research and Training, School of Public Health, Sun Yat-Sen University, Guangzhou, People's Republic of China.; National Medical Products Administration Key Laboratory for Quality Monitoring and Evaluation of Vaccines and Biological Products, Guangzhou, People's Republic of China.; Key Laboratory of Tropical Diseases Control, Sun Yat-Sen University, Ministry of Education, Guangzhou, People's Republic of China.; Research Institute of Sun Yat-Sen University in Shenzhen, Shenzhen, People's Republic of China.; Hainan Key Novel Thinktank 'Hainan Medical University 'One Health' Research Center', Haikou, People's Republic of China.
Chen Z; One Health Center of Excellence for Research and Training, School of Public Health, Sun Yat-Sen University, Guangzhou, People's Republic of China.; National Medical Products Administration Key Laboratory for Quality Monitoring and Evaluation of Vaccines and Biological Products, Guangzhou, People's Republic of China.; Key Laboratory of Tropical Diseases Control, Sun Yat-Sen University, Ministry of Education, Guangzhou, People's Republic of China.; Key Laboratory of Zoonose Prevention and Control at Universities of Inner Mongolia Autonomous Region, Medical College, Inner Mongolia Minzu University, Tongliao, People's Republic of China.
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Źródło:
International journal of nanomedicine [Int J Nanomedicine] 2023 Jan 19; Vol. 18, pp. 353-367. Date of Electronic Publication: 2023 Jan 19 (Print Publication: 2023).
Typ publikacji:
Journal Article
MeSH Terms:
COVID-19*
Single-Domain Antibodies*
Humans ; SARS-CoV-2 ; Epitopes ; Antibodies, Neutralizing ; Antibodies, Viral
SCR Organism:
SARS-CoV-2 variants; Aquifex aeolicus
Czasopismo naukowe
Tytuł:
Epistasis lowers the genetic barrier to SARS-CoV-2 neutralizing antibody escape.
Autorzy:
Witte L; Laboratory of Retrovirology, The Rockefeller University, New York, NY, 10065, USA.
Baharani VA; Laboratory of Retrovirology, The Rockefeller University, New York, NY, 10065, USA.; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, 10065, USA.
Schmidt F; Laboratory of Retrovirology, The Rockefeller University, New York, NY, 10065, USA.
Wang Z; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, 10065, USA.
Cho A; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, 10065, USA.
Raspe R; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, 10065, USA.
Guzman-Cardozo C; Laboratory of Retrovirology, The Rockefeller University, New York, NY, 10065, USA.
Muecksch F; Laboratory of Retrovirology, The Rockefeller University, New York, NY, 10065, USA.
Canis M; Laboratory of Retrovirology, The Rockefeller University, New York, NY, 10065, USA.
Park DJ; Laboratory of Retrovirology, The Rockefeller University, New York, NY, 10065, USA.
Gaebler C; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, 10065, USA.
Caskey M; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, 10065, USA.
Nussenzweig MC; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, 10065, USA. .; Howard Hughes Medical Institute, The Rockefeller University, New York, NY, 10065, USA. .
Hatziioannou T; Laboratory of Retrovirology, The Rockefeller University, New York, NY, 10065, USA. .
Bieniasz PD; Laboratory of Retrovirology, The Rockefeller University, New York, NY, 10065, USA. .; Howard Hughes Medical Institute, The Rockefeller University, New York, NY, 10065, USA. .
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Źródło:
Nature communications [Nat Commun] 2023 Jan 19; Vol. 14 (1), pp. 302. Date of Electronic Publication: 2023 Jan 19.
Typ publikacji:
Journal Article
MeSH Terms:
Antibodies, Neutralizing*
COVID-19*
Humans ; SARS-CoV-2/genetics ; Broadly Neutralizing Antibodies ; Epistasis, Genetic ; Spike Glycoprotein, Coronavirus/genetics ; Antibodies, Viral
SCR Organism:
SARS-CoV-2 variants
Czasopismo naukowe
Tytuł:
Alarming antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants.
Autorzy:
Wang Q; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Iketani S; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Li Z; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Liu L; Department of Systems Biology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Guo Y; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Huang Y; Department of Systems Biology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Bowen AD; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA; Division of Infectious Diseases, Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Liu M; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Wang M; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Yu J; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Valdez R; Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.
Lauring AS; Division of Infectious Diseases, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Sheng Z; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Wang HH; Department of Systems Biology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Gordon A; Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.
Liu L; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA. Electronic address: .
Ho DD; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA; Division of Infectious Diseases, Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA; Department of Microbiology and Immunology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA. Electronic address: .
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Źródło:
Cell [Cell] 2023 Jan 19; Vol. 186 (2), pp. 279-286.e8. Date of Electronic Publication: 2022 Dec 14.
Typ publikacji:
Journal Article
MeSH Terms:
Antibodies, Viral*
COVID-19*/immunology
COVID-19*/virology
SARS-CoV-2*/classification
SARS-CoV-2*/genetics
Immune Evasion*
Humans ; Antibodies, Monoclonal ; Antibodies, Neutralizing ; COVID-19 Vaccines
SCR Organism:
SARS-CoV-2 variants
Czasopismo naukowe
Tytuł:
Nanobody derived using a peptide epitope from the spike protein receptor-binding motif inhibits entry of SARS-CoV-2 variants.
Autorzy:
Mendon N; Centre for Cardiovascular Biology and Disease, Institute for Stem Cell Science and Regenerative Medicine, GKVK Campus, Bengaluru, India; Manipal Academy of Higher Education, Manipal, Karnataka, India.
Ganie RA; Centre for Cardiovascular Biology and Disease, Institute for Stem Cell Science and Regenerative Medicine, GKVK Campus, Bengaluru, India; Manipal Academy of Higher Education, Manipal, Karnataka, India.
Kesarwani S; Centre for Cardiovascular Biology and Disease, Institute for Stem Cell Science and Regenerative Medicine, GKVK Campus, Bengaluru, India.
Dileep D; Centre for Cardiovascular Biology and Disease, Institute for Stem Cell Science and Regenerative Medicine, GKVK Campus, Bengaluru, India; The University of Trans-Disciplinary Health Sciences and Technology (TDU), Bengaluru, India.
Sasi S; Centre for Cardiovascular Biology and Disease, Institute for Stem Cell Science and Regenerative Medicine, GKVK Campus, Bengaluru, India.
Lama P; Centre for Cardiovascular Biology and Disease, Institute for Stem Cell Science and Regenerative Medicine, GKVK Campus, Bengaluru, India; Manipal Academy of Higher Education, Manipal, Karnataka, India.
Chandra A; National Centre for Biological Sciences, TIFR, GKVK Campus, Bengaluru, India.
Sirajuddin M; Centre for Cardiovascular Biology and Disease, Institute for Stem Cell Science and Regenerative Medicine, GKVK Campus, Bengaluru, India. Electronic address: .
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Źródło:
The Journal of biological chemistry [J Biol Chem] 2023 Jan; Vol. 299 (1), pp. 102732. Date of Electronic Publication: 2022 Nov 22.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
SARS-CoV-2*/physiology
Virus Internalization*/drug effects
Single-Domain Antibodies*/pharmacology
Humans ; Antibodies, Neutralizing/pharmacology ; Antibodies, Viral ; COVID-19 ; Epitopes ; Peptides ; Spike Glycoprotein, Coronavirus/chemistry
SCR Organism:
SARS-CoV-2 variants
Czasopismo naukowe
Tytuł:
Antibody feedback regulates immune memory after SARS-CoV-2 mRNA vaccination.
Autorzy:
Schaefer-Babajew D; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.
Wang Z; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.
Muecksch F; Laboratory of Retrovirology, The Rockefeller University, New York, NY, USA.
Cho A; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.
Loewe M; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.
Cipolla M; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.
Raspe R; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.
Johnson B; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.
Canis M; Laboratory of Retrovirology, The Rockefeller University, New York, NY, USA.
DaSilva J; Laboratory of Retrovirology, The Rockefeller University, New York, NY, USA.
Ramos V; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.
Turroja M; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.
Millard KG; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.
Schmidt F; Laboratory of Retrovirology, The Rockefeller University, New York, NY, USA.
Witte L; Laboratory of Retrovirology, The Rockefeller University, New York, NY, USA.
Dizon J; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.
Shimeliovich I; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.
Yao KH; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.
Oliveira TY; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.
Gazumyan A; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.; Howard Hughes Medical Institute, New York, NY, USA.
Gaebler C; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.
Bieniasz PD; Laboratory of Retrovirology, The Rockefeller University, New York, NY, USA. .; Howard Hughes Medical Institute, New York, NY, USA. .
Hatziioannou T; Laboratory of Retrovirology, The Rockefeller University, New York, NY, USA. .
Caskey M; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA. .
Nussenzweig MC; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA. .; Howard Hughes Medical Institute, New York, NY, USA. .
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Źródło:
Nature [Nature] 2023 Jan; Vol. 613 (7945), pp. 735-742. Date of Electronic Publication: 2022 Dec 06.
Typ publikacji:
Journal Article
MeSH Terms:
Antibodies, Viral*/immunology
COVID-19*/immunology
COVID-19*/prevention & control
COVID-19*/therapy
COVID-19*/virology
Immunologic Memory*
Vaccination*
mRNA Vaccines*/immunology
COVID-19 Vaccines*/immunology
B-Lymphocytes*/immunology
B-Lymphocytes*/metabolism
Feedback, Physiological*
Animals ; Mice ; Antibodies, Monoclonal/immunology ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Neutralizing/immunology ; SARS-CoV-2/immunology ; Epitopes, B-Lymphocyte/chemistry ; Epitopes, B-Lymphocyte/immunology ; Immunoglobulin M/immunology ; Germinal Center/cytology ; Germinal Center/immunology ; Immunization, Secondary ; Somatic Hypermutation, Immunoglobulin
Czasopismo naukowe
Tytuł:
Omicron sublineage BQ.1.1 resistance to monoclonal antibodies.
Autorzy:
Arora P; Infection Biology Unit, German Primate Centre, Leibniz Institute for Primate Research, 37077 Göttingen, Germany; Faculty of Biology and Psychology, Georg-August-University Göttingen, Göttingen, Germany.
Kempf A; Infection Biology Unit, German Primate Centre, Leibniz Institute for Primate Research, 37077 Göttingen, Germany; Faculty of Biology and Psychology, Georg-August-University Göttingen, Göttingen, Germany.
Nehlmeier I; Infection Biology Unit, German Primate Centre, Leibniz Institute for Primate Research, 37077 Göttingen, Germany.
Schulz SR; Division of Molecular Immunology, Department of Internal Medicine 3, Friedrich-Alexander University of Erlangen-Nürnberg, 91054 Erlangen, Germany.
Jäck HM; Division of Molecular Immunology, Department of Internal Medicine 3, Friedrich-Alexander University of Erlangen-Nürnberg, 91054 Erlangen, Germany.
Pöhlmann S; Infection Biology Unit, German Primate Centre, Leibniz Institute for Primate Research, 37077 Göttingen, Germany; Faculty of Biology and Psychology, Georg-August-University Göttingen, Göttingen, Germany.
Hoffmann M; Infection Biology Unit, German Primate Centre, Leibniz Institute for Primate Research, 37077 Göttingen, Germany; Faculty of Biology and Psychology, Georg-August-University Göttingen, Göttingen, Germany. Electronic address: .
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Źródło:
The Lancet. Infectious diseases [Lancet Infect Dis] 2023 Jan; Vol. 23 (1), pp. 22-23. Date of Electronic Publication: 2022 Nov 18.
Typ publikacji:
Letter
MeSH Terms:
Antibodies, Monoclonal*/therapeutic use
Antibodies, Viral*
Humans ; Antibodies, Neutralizing
Opinia redakcyjna
Tytuł:
The third inactivated vaccine booster dramatically enhanced SARS-CoV-2 antibody responses and did not influence the profile of prothrombotic antibody.
Autorzy:
Pan Y; Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, Hubei, China.; Hubei Engineering Center for Infectious Disease Prevention, Control and Treatment, Wuhan, Hubei, China.; Wuhan Research Center for Infectious Diseases and Tumors of the Chinese Academy of Medical Sciences, Wuhan, Hubei, China.
Wang S; Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, Hubei, China.; Hubei Engineering Center for Infectious Disease Prevention, Control and Treatment, Wuhan, Hubei, China.
Liu G; Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, China.
Wang L; Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, Hubei, China.
Yang L; Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, Hubei, China.
Zeng X; Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, Hubei, China.
Qian C; The Key Laboratory for Biomedical Photonics of MOE at Wuhan National Laboratory for Optoelectronics - Hubei Bioinformatics & Molecular Imaging Key Laboratory, Systems Biology Theme, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Lin J; Hubei Engineering Center for Infectious Disease Prevention, Control and Treatment, Wuhan, Hubei, China.; Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, China.
Pan Z; Hubei Engineering Center for Infectious Disease Prevention, Control and Treatment, Wuhan, Hubei, China.; Wuhan Research Center for Infectious Diseases and Tumors of the Chinese Academy of Medical Sciences, Wuhan, Hubei, China.; Department of Orthopedics, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, Hubei, China.
Li Y; Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, Hubei, China.; Hubei Engineering Center for Infectious Disease Prevention, Control and Treatment, Wuhan, Hubei, China.; Wuhan Research Center for Infectious Diseases and Tumors of the Chinese Academy of Medical Sciences, Wuhan, Hubei, China.
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Źródło:
Journal of medical virology [J Med Virol] 2023 Jan; Vol. 95 (1), pp. e28356.
Typ publikacji:
Journal Article
MeSH Terms:
Antibodies, Viral*
Antibody Formation*
COVID-19*/prevention & control
COVID-19 Vaccines*/immunology
SARS-CoV-2*/immunology
Humans ; Antibodies, Antiphospholipid ; Antibodies, Neutralizing ; Autoantibodies ; Immunoglobulin G/chemistry ; Vaccination ; Vaccines, Inactivated/immunology
Czasopismo naukowe
Tytuł:
Switching to emicizumab: A prospective surveillance study in haemophilia A subjects with inhibitors.
Autorzy:
Dubé E; CHU Sainte-Justine, Montréal, Canada.
Merlen C; CHU Sainte-Justine, Montréal, Canada.
Bonnefoy A; CHU Sainte-Justine, Montréal, Canada.
Pilon J; CHU Sainte-Justine, Montréal, Canada.
Zourikian N; CHU Sainte-Justine, Montréal, Canada.
Gauthier J; CHU Sainte-Justine, Montréal, Canada.
St-Louis J; CHU Sainte-Justine, Montréal, Canada.; Hôpital Maisonneuve-Rosemont, Montréal, Canada.
Rivard GÉ; CHU Sainte-Justine, Montréal, Canada.
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Źródło:
Haemophilia : the official journal of the World Federation of Hemophilia [Haemophilia] 2023 Jan; Vol. 29 (1), pp. 348-351. Date of Electronic Publication: 2022 Oct 31.
Typ publikacji:
Letter
MeSH Terms:
Hemophilia A*/drug therapy
Antibodies, Bispecific*/pharmacology
Antibodies, Bispecific*/therapeutic use
Humans ; Prospective Studies ; Antibodies, Monoclonal, Humanized/therapeutic use ; Antibodies, Monoclonal, Humanized/pharmacology ; Factor VIII/therapeutic use
Opinia redakcyjna
Tytuł:
Monoclonal Antibodies Specific for SARS-CoV-2 Spike Protein Suitable for Multiple Applications for Current Variants of Concern.
Autorzy:
Morgan MS; School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, QLD 4072, Australia.
Yan K; Inflammation Biology, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia.
Le TT; Inflammation Biology, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia.
Johnston RA; School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, QLD 4072, Australia.
Amarilla AA; School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, QLD 4072, Australia.
Muller DA; School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, QLD 4072, Australia.; Global Virus Network Centre of Excellence, Australian Infectious Diseases Research Centre, Brisbane, QLD 4072 and 4029, Australia.
McMillan CLD; School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, QLD 4072, Australia.; Global Virus Network Centre of Excellence, Australian Infectious Diseases Research Centre, Brisbane, QLD 4072 and 4029, Australia.
Modhiran N; School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, QLD 4072, Australia.
Watterson D; School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, QLD 4072, Australia.
Potter JR; School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, QLD 4072, Australia.
Sng JDJ; School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, QLD 4072, Australia.
Lor M; Inflammation Biology, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia.
Paramitha D; School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, QLD 4072, Australia.
Isaacs A; School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, QLD 4072, Australia.
Khromykh AA; School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, QLD 4072, Australia.; Global Virus Network Centre of Excellence, Australian Infectious Diseases Research Centre, Brisbane, QLD 4072 and 4029, Australia.
Hall RA; School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, QLD 4072, Australia.; Global Virus Network Centre of Excellence, Australian Infectious Diseases Research Centre, Brisbane, QLD 4072 and 4029, Australia.
Suhrbier A; Inflammation Biology, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia.; Global Virus Network Centre of Excellence, Australian Infectious Diseases Research Centre, Brisbane, QLD 4072 and 4029, Australia.
Rawle DJ; Inflammation Biology, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia.
Hobson-Peters J; School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, QLD 4072, Australia.; Global Virus Network Centre of Excellence, Australian Infectious Diseases Research Centre, Brisbane, QLD 4072 and 4029, Australia.
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Źródło:
Viruses [Viruses] 2022 Dec 31; Vol. 15 (1). Date of Electronic Publication: 2022 Dec 31.
Typ publikacji:
Journal Article
MeSH Terms:
Antibodies, Monoclonal*
COVID-19*
Animals ; Humans ; Mice ; Spike Glycoprotein, Coronavirus/genetics ; SARS-CoV-2/genetics ; Mice, Transgenic ; Antibodies, Viral ; Antibodies, Neutralizing
SCR Organism:
SARS-CoV-2 variants
Czasopismo naukowe
Tytuł:
Effectiveness of Sotrovimab in the Omicron Storm Time: A Case Series.
Autorzy:
Cicchitto G; COVID-19 Hospital 'M. Scarlato', Department of Pneumology, 84018 Salerno, Italy.
Cardillo L; Istituto Zooprofilattico Sperimentale del Mezzogiorno, Via Salute 2, 80055 Naples, Italy.
Sequino D; Department of Clinical Medicine and Surgery, Section of Respiratory Disease Federico II University Hospital, 80055 Naples, Italy.
Sabatini P; Umberto I' Hospital, Unit of Virology and Microbiology, Nocera Inferiore, 84018 Salerno, Italy.
Adamo L; Umberto I' Hospital, Unit of Virology and Microbiology, Nocera Inferiore, 84018 Salerno, Italy.
Marchitiello R; COVID-19 Hospital 'M. Scarlato', Unit of Clinical Pathology Laboratory, 84018 Salerno, Italy.
Viscardi M; Istituto Zooprofilattico Sperimentale del Mezzogiorno, Via Salute 2, 80055 Naples, Italy.
Cozzolino L; Istituto Zooprofilattico Sperimentale del Mezzogiorno, Via Salute 2, 80055 Naples, Italy.
Cavallera A; COVID-19 Hospital 'M. Scarlato', Department of Radiology, 84018 Salerno, Italy.
Bocchino M; Department of Clinical Medicine and Surgery, Section of Respiratory Disease Federico II University Hospital, 80055 Naples, Italy.
Sanduzzi Zamparelli A; Department of Clinical Medicine and Surgery, Section of Respiratory Disease Federico II University Hospital, 80055 Naples, Italy.
Ferrigno F; COVID-19 Hospital 'M. Scarlato', Department of Pneumology, 84018 Salerno, Italy.
de Carlo E; Istituto Zooprofilattico Sperimentale del Mezzogiorno, Via Salute 2, 80055 Naples, Italy.
de Martinis C; Istituto Zooprofilattico Sperimentale del Mezzogiorno, Via Salute 2, 80055 Naples, Italy.
Fusco G; Istituto Zooprofilattico Sperimentale del Mezzogiorno, Via Salute 2, 80055 Naples, Italy.
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Źródło:
Viruses [Viruses] 2022 Dec 30; Vol. 15 (1). Date of Electronic Publication: 2022 Dec 30.
Typ publikacji:
Observational Study; Journal Article
MeSH Terms:
Antibodies, Monoclonal, Humanized*/therapeutic use
Antibodies, Neutralizing*/therapeutic use
COVID-19*/therapy
Humans ; Antibodies, Viral ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus
SCR Organism:
SARS-CoV-2 variants
Czasopismo naukowe
Tytuł:
Broadly neutralizing and protective nanobodies against SARS-CoV-2 Omicron subvariants BA.1, BA.2, and BA.4/5 and diverse sarbecoviruses.
Autorzy:
Li M; Center for Global Health and Infectious Diseases, Comprehensive AIDS Research Center, NexVac Research Center, Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, 100084, China.
Ren Y; The Ministry of Education Key Laboratory of Protein Science, Beijing Advanced Innovation Center for Structural Biology, Beijing Frontier Research Center for Biological Structure, Collaborative Innovation Center for Biotherapy, School of Life Sciences, Tsinghua University, Beijing, 100084, China.; Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, 100084, China.
Aw ZQ; Biosafety Level 3 Core Facility, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119077, Singapore.; Laboratory of Molecular RNA Virology and Antiviral Strategies, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119077, Singapore.; Infectious Disease Translation Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119077, Singapore.
Chen B; NB BIOLAB Co., Ltd, Chengdu, 611137, China.
Yang Z; Center for Global Health and Infectious Diseases, Comprehensive AIDS Research Center, NexVac Research Center, Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, 100084, China.
Lei Y; Center for Global Health and Infectious Diseases, Comprehensive AIDS Research Center, NexVac Research Center, Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, 100084, China.
Cheng L; Institute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People's Hospital, Shenzhen, 518112, China.; The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen, 518112, China.
Liang Q; Center for Global Health and Infectious Diseases, Comprehensive AIDS Research Center, NexVac Research Center, Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, 100084, China.
Hong J; Center for Global Health and Infectious Diseases, Comprehensive AIDS Research Center, NexVac Research Center, Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, 100084, China.
Yang Y; Center for Global Health and Infectious Diseases, Comprehensive AIDS Research Center, NexVac Research Center, Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, 100084, China.
Chen J; The Ministry of Education Key Laboratory of Protein Science, Beijing Advanced Innovation Center for Structural Biology, Beijing Frontier Research Center for Biological Structure, Collaborative Innovation Center for Biotherapy, School of Life Sciences, Tsinghua University, Beijing, 100084, China.; Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, 100084, China.
Wong YH; Biosafety Level 3 Core Facility, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119077, Singapore.; Laboratory of Molecular RNA Virology and Antiviral Strategies, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119077, Singapore.; Infectious Disease Translation Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119077, Singapore.
Wei J; Center for Global Health and Infectious Diseases, Comprehensive AIDS Research Center, NexVac Research Center, Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, 100084, China.
Shan S; Center for Global Health and Infectious Diseases, Comprehensive AIDS Research Center, NexVac Research Center, Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, 100084, China.
Zhang S; The Ministry of Education Key Laboratory of Protein Science, Beijing Advanced Innovation Center for Structural Biology, Beijing Frontier Research Center for Biological Structure, Collaborative Innovation Center for Biotherapy, School of Life Sciences, Tsinghua University, Beijing, 100084, China.
Ge J; The Ministry of Education Key Laboratory of Protein Science, Beijing Advanced Innovation Center for Structural Biology, Beijing Frontier Research Center for Biological Structure, Collaborative Innovation Center for Biotherapy, School of Life Sciences, Tsinghua University, Beijing, 100084, China.; Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, 100084, China.
Wang R; Center for Global Health and Infectious Diseases, Comprehensive AIDS Research Center, NexVac Research Center, Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, 100084, China.
Dong JZ; HplanetBio Co., Ltd, Shanghai, 200131, China.
Chen Y; Hua Bio Co., Ltd, Hangzhou, 310018, China.
Shi X; Center for Global Health and Infectious Diseases, Comprehensive AIDS Research Center, NexVac Research Center, Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, 100084, China.
Zhang Q; Center for Global Health and Infectious Diseases, Comprehensive AIDS Research Center, NexVac Research Center, Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, 100084, China.
Zhang Z; Institute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People's Hospital, Shenzhen, 518112, China.; The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen, 518112, China.
Chu JJH; Biosafety Level 3 Core Facility, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119077, Singapore. .; Laboratory of Molecular RNA Virology and Antiviral Strategies, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119077, Singapore. .; Infectious Disease Translation Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119077, Singapore. .; Collaborative and Translation Unit for HFMD, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, 138673, Singapore. .
Wang X; The Ministry of Education Key Laboratory of Protein Science, Beijing Advanced Innovation Center for Structural Biology, Beijing Frontier Research Center for Biological Structure, Collaborative Innovation Center for Biotherapy, School of Life Sciences, Tsinghua University, Beijing, 100084, China. .
Zhang L; Center for Global Health and Infectious Diseases, Comprehensive AIDS Research Center, NexVac Research Center, Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, 100084, China. .; Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, China. .; Institute of Biomedical Health Technology and Engineering, Shenzhen Bay Laboratory, Shenzhen, 518132, China. .
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Źródło:
Nature communications [Nat Commun] 2022 Dec 27; Vol. 13 (1), pp. 7957. Date of Electronic Publication: 2022 Dec 27.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Severe acute respiratory syndrome-related coronavirus*
Single-Domain Antibodies*
COVID-19*/prevention & control
Camelids, New World*
Animals ; Mice ; SARS-CoV-2 ; Angiotensin-Converting Enzyme 2 ; Antibodies, Neutralizing ; Spike Glycoprotein, Coronavirus ; Antibodies, Viral
Czasopismo naukowe
Tytuł:
Antibodies targeting the neuraminidase active site inhibit influenza H3N2 viruses with an S245N glycosylation site.
Autorzy:
Stadlbauer D; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
McMahon M; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Turner HL; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.
Zhu X; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.
Wan H; Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA.
Carreño JM; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
O'Dell G; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Strohmeier S; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Biotechnology, University of Natural Resources and Life Sciences, Vienna, Austria.
Khalil Z; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Luksza M; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
van Bakel H; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Simon V; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Pathology, Molecular and Cell Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Center for Vaccine Research and Pandemic Preparedness (C-VaRPP), Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ellebedy AH; Division of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA. .
Wilson IA; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA. .; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA. .
Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA. .
Krammer F; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. .; Department of Pathology, Molecular and Cell Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. .; Center for Vaccine Research and Pandemic Preparedness (C-VaRPP), Icahn School of Medicine at Mount Sinai, New York, NY, USA. .
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Źródło:
Nature communications [Nat Commun] 2022 Dec 21; Vol. 13 (1), pp. 7864. Date of Electronic Publication: 2022 Dec 21.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Antibodies, Monoclonal*/chemistry
Antibodies, Monoclonal*/immunology
Influenza A Virus, H3N2 Subtype*/immunology
Influenza A Virus, H3N2 Subtype*/metabolism
Neuraminidase*/chemistry
Neuraminidase*/immunology
Humans ; Antibodies, Viral/chemistry ; Antibodies, Viral/metabolism ; Catalytic Domain/immunology ; Catalytic Domain/physiology ; Glycosylation ; Hemagglutinin Glycoproteins, Influenza Virus ; Influenza A virus ; Influenza, Human/immunology ; Influenza, Human/metabolism
Czasopismo naukowe
Tytuł:
A broadly neutralizing monoclonal antibody overcomes the mutational landscape of emerging SARS-CoV-2 variants of concern.
Autorzy:
Parray HA; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Narayanan N; Regional Centre for Biotechnology, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Garg S; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Rizvi ZA; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Shrivastava T; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Kushwaha S; National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, India.
Singh J; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Murugavelu P; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Anantharaj A; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Mehdi F; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Raj N; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Singh S; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Dandotiya J; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Lukose A; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Jamwal D; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Kumar S; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Chiranjivi AK; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Dhyani S; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Mishra N; Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India.
Kumar S; ICGEB-Emory Vaccine Center, International Centre for Genetic Engineering and Biotechnology, New Delhi, India.
Jakhar K; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Sonar S; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Panchal AK; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Tripathy MR; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Chowdhury SR; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Ahmed S; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Samal S; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Mani S; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Bhattacharyya S; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Das S; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Sinha S; Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India.
Luthra K; Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India.
Batra G; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Sehgal D; National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, India.
Medigeshi GR; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Sharma C; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Awasthi A; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Garg PK; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Nair DT; Regional Centre for Biotechnology, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Kumar R; Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
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Źródło:
PLoS pathogens [PLoS Pathog] 2022 Dec 12; Vol. 18 (12), pp. e1010994. Date of Electronic Publication: 2022 Dec 12 (Print Publication: 2022).
Typ publikacji:
Journal Article
MeSH Terms:
Angiotensin-Converting Enzyme 2*/chemistry
Antibodies, Neutralizing*/therapeutic use
COVID-19*/immunology
COVID-19*/therapy
SARS-CoV-2*/genetics
SARS-CoV-2*/immunology
Animals ; Humans ; Mice ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Viral/therapeutic use ; Mice, Transgenic ; Neutralization Tests ; Spike Glycoprotein, Coronavirus/genetics
SCR Organism:
SARS-CoV-2 variants
Czasopismo naukowe
Tytuł:
Myomedin replicas of gp120 V3 loop glycan epitopes recognized by PGT121 and PGT126 antibodies as non-cognate antigens for stimulation of HIV-1 broadly neutralizing antibodies.
Autorzy:
Daniel Lišková V; Laboratory of Ligand Engineering, Institute of Biotechnology of the Czech Academy of Sciences, BIOCEV Research Center, Prumyslova, Vestec, Czechia.
Kosztyu P; Department of Immunology, Palacky University Olomouc, Hnevotinska, Olomouc, Czechia.
Kuchař M; Laboratory of Ligand Engineering, Institute of Biotechnology of the Czech Academy of Sciences, BIOCEV Research Center, Prumyslova, Vestec, Czechia.
Černý J; Laboratory of Structural Bioinformatics of Proteins, Institute of Biotechnology of the Czech Academy of Sciences, BIOCEV Research Center, Prumyslova, Vestec, Czechia.
Bharadwaj S; Laboratory of Ligand Engineering, Institute of Biotechnology of the Czech Academy of Sciences, BIOCEV Research Center, Prumyslova, Vestec, Czechia.
Petroková H; Laboratory of Ligand Engineering, Institute of Biotechnology of the Czech Academy of Sciences, BIOCEV Research Center, Prumyslova, Vestec, Czechia.
Vroblová E; Department of Immunology, Palacky University Olomouc, Hnevotinska, Olomouc, Czechia.
Křupka M; Department of Immunology, Palacky University Olomouc, Hnevotinska, Olomouc, Czechia.
Malý M; Laboratory of Ligand Engineering, Institute of Biotechnology of the Czech Academy of Sciences, BIOCEV Research Center, Prumyslova, Vestec, Czechia.; Laboratory of Structural Bioinformatics of Proteins, Institute of Biotechnology of the Czech Academy of Sciences, BIOCEV Research Center, Prumyslova, Vestec, Czechia.
Zosinčuková T; Laboratory of Ligand Engineering, Institute of Biotechnology of the Czech Academy of Sciences, BIOCEV Research Center, Prumyslova, Vestec, Czechia.
Šulc J; Laboratory of Ligand Engineering, Institute of Biotechnology of the Czech Academy of Sciences, BIOCEV Research Center, Prumyslova, Vestec, Czechia.
Rašková Kafková L; Department of Immunology, Palacky University Olomouc, Hnevotinska, Olomouc, Czechia.
Raška M; Department of Immunology, Palacky University Olomouc, Hnevotinska, Olomouc, Czechia.
Malý P; Laboratory of Ligand Engineering, Institute of Biotechnology of the Czech Academy of Sciences, BIOCEV Research Center, Prumyslova, Vestec, Czechia.
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Źródło:
Frontiers in immunology [Front Immunol] 2022 Dec 08; Vol. 13, pp. 1066361. Date of Electronic Publication: 2022 Dec 08 (Print Publication: 2022).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
HIV Antibodies*
HIV-1*
Animals ; Mice ; Epitopes ; Broadly Neutralizing Antibodies ; Antibodies, Neutralizing ; HIV Envelope Protein gp120 ; Polysaccharides
Czasopismo naukowe
Tytuł:
Computational epitope mapping of class I fusion proteins using low complexity supervised learning methods.
Autorzy:
Fischer MFS; Department of Chemistry, Vanderbilt University, Nashville, Tennessee, United States of America.; Center for Structural Biology, Vanderbilt University, Nashville, Tennessee, United States of America.
Crowe JE; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America.; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America.; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America.
Meiler J; Department of Chemistry, Vanderbilt University, Nashville, Tennessee, United States of America.; Center for Structural Biology, Vanderbilt University, Nashville, Tennessee, United States of America.; Institute for Drug Discovery, Leipzig University Medical School, Leipzig, Saxony, Germany.
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Źródło:
PLoS computational biology [PLoS Comput Biol] 2022 Dec 07; Vol. 18 (12), pp. e1010230. Date of Electronic Publication: 2022 Dec 07 (Print Publication: 2022).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Antibodies, Monoclonal*
Antibodies, Neutralizing*
Epitope Mapping/methods ; Cryoelectron Microscopy ; Epitopes ; Supervised Machine Learning ; Antibodies, Viral
Czasopismo naukowe
Tytuł:
Anti-TGF-β/PD-L1 bispecific antibody promotes T cell infiltration and exhibits enhanced antitumor activity in triple-negative breast cancer.
Autorzy:
Yi M; Department of Breast Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.; Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Wu Y; Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Niu M; Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Zhu S; Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Zhang J; Wuhan YZY Biopharma Co Ltd, Wuhan, China.
Yan Y; Wuhan YZY Biopharma Co Ltd, Wuhan, China.
Zhou P; Wuhan YZY Biopharma Co Ltd, Wuhan, China.
Dai Z; Department of Breast Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China .
Wu K; Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China .; Cancer Center, Shanxi Bethune Hospital, Shanxi Academy of Medical Science, Third Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
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Źródło:
Journal for immunotherapy of cancer [J Immunother Cancer] 2022 Dec; Vol. 10 (12).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Triple Negative Breast Neoplasms*/drug therapy
Antibodies, Bispecific*/pharmacology
Antibodies, Bispecific*/therapeutic use
Humans ; Mice ; Animals ; Transforming Growth Factor beta ; Pilot Projects ; Antibodies, Neoplasm ; Tumor Microenvironment
Czasopismo naukowe

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