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Tytuł :
Structure-based Design of a Specific, Homogeneous Luminescence Enzyme Reporter Assay for SARS-CoV-2.
Autorzy :
Fellouse FA; The Donnelly Centre, University of Toronto, Toronto, Canada; Department of Molecular Genetics, University of Toronto, Toronto, Canada. Electronic address: .
Miersch S; The Donnelly Centre, University of Toronto, Toronto, Canada; Department of Molecular Genetics, University of Toronto, Toronto, Canada.
Chen C; The Donnelly Centre, University of Toronto, Toronto, Canada; Department of Molecular Genetics, University of Toronto, Toronto, Canada.
Michnick SW; Département de Biochimie, Université de Montréal, Montréal, Canada. Electronic address: .
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Źródło :
Journal of molecular biology [J Mol Biol] 2021 Jun 25; Vol. 433 (13), pp. 166983. Date of Electronic Publication: 2021 Apr 08.
Typ publikacji :
Journal Article
MeSH Terms :
Antibodies, Viral/*chemistry
Antigens, Viral/*immunology
COVID-19/*diagnosis
COVID-19/*virology
SARS-CoV-2/*isolation & purification
Angiotensin-Converting Enzyme 2/chemistry ; Angiotensin-Converting Enzyme 2/immunology ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/genetics ; Antibodies, Viral/immunology ; Antigens, Viral/chemistry ; Antigens, Viral/isolation & purification ; Epitopes/immunology ; Humans ; Immunoglobulin G/chemistry ; Immunoglobulin G/immunology ; Luciferases ; Luminescent Measurements/methods ; Protein Engineering ; SARS-CoV-2/chemistry ; SARS-CoV-2/immunology ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/immunology
Czasopismo naukowe
Tytuł :
Antibody fucosylation predicts disease severity in secondary dengue infection.
Autorzy :
Bournazos S; Laboratory of Molecular Genetics and Immunology, The Rockefeller University, New York, NY, USA.
Vo HTM; Immunology Unit, Institut Pasteur du Cambodge, Institut Pasteur International Network, Phnom Penh, Cambodia.
Duong V; Virology Unit, Institut Pasteur du Cambodge, Institut Pasteur International Network, Phnom Penh, Cambodia.
Auerswald H; Virology Unit, Institut Pasteur du Cambodge, Institut Pasteur International Network, Phnom Penh, Cambodia.
Ly S; Epidemiology and Public Health Unit, Institut Pasteur du Cambodge, Institut Pasteur International Network, Phnom Penh, Cambodia.
Sakuntabhai A; Functional Genetics of Infectious Diseases Unit, Department of Global Health, Institut Pasteur, Paris Cedex 15, France.; Centre National de la Recherche Scientifique (CNRS), UMR2000, Paris Cedex 15, France.
Dussart P; Virology Unit, Institut Pasteur du Cambodge, Institut Pasteur International Network, Phnom Penh, Cambodia.
Cantaert T; Immunology Unit, Institut Pasteur du Cambodge, Institut Pasteur International Network, Phnom Penh, Cambodia. .
Ravetch JV; Laboratory of Molecular Genetics and Immunology, The Rockefeller University, New York, NY, USA. .
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Źródło :
Science (New York, N.Y.) [Science] 2021 Jun 04; Vol. 372 (6546), pp. 1102-1105.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Viral/*blood
Antibodies, Viral/*chemistry
Dengue/*immunology
Dengue Virus/*immunology
Fucose/*analysis
Severe Dengue/*immunology
Antibodies, Neutralizing/blood ; Antibodies, Neutralizing/chemistry ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology ; Antibody-Dependent Enhancement ; Child ; Coinfection/immunology ; Dengue/physiopathology ; Female ; Humans ; Immunoglobulin Fc Fragments/chemistry ; Immunoglobulin Fc Fragments/immunology ; Immunoglobulin G/blood ; Immunoglobulin G/chemistry ; Immunoglobulin G/immunology ; Male ; Receptors, IgG/chemistry ; Receptors, IgG/immunology ; Severe Dengue/physiopathology ; Severity of Illness Index ; Zika Virus Infection/immunology
Czasopismo naukowe
Tytuł :
Prevalent, protective, and convergent IgG recognition of SARS-CoV-2 non-RBD spike epitopes.
Autorzy :
Voss WN; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.
Hou YJ; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Johnson NV; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.
Delidakis G; Department of Chemical Engineering, The University of Texas at Austin, Austin, TX, USA.
Kim JE; Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA.
Javanmardi K; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.
Horton AP; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.
Bartzoka F; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.
Paresi CJ; Department of Chemistry, The University of Texas at Austin, Austin, TX, USA.
Tanno Y; Department of Chemical Engineering, The University of Texas at Austin, Austin, TX, USA.
Chou CW; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.
Abbasi SA; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD, USA.
Pickens W; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.
George K; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.
Boutz DR; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.; CCDC Army Research Laboratory-South, The University of Texas at Austin, Austin, TX, USA.
Towers DM; Department of Chemical Engineering, The University of Texas at Austin, Austin, TX, USA.
McDaniel JR; Biomedicine Design, Pfizer, Cambridge, MA, USA.
Billick D; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.
Goike J; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.
Rowe L; Biotechnology Core Facility Branch, Division of Scientific Resources, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.; Tulane National Primate Research Center Department of Microbiology 18703 Three Rivers Road Covington, LA, USA.
Batra D; Biotechnology Core Facility Branch, Division of Scientific Resources, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Pohl J; Biotechnology Core Facility Branch, Division of Scientific Resources, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Lee J; Biotechnology Core Facility Branch, Division of Scientific Resources, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Gangappa S; Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Sambhara S; Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Gadush M; Center for Biomedical Research Support, The University of Texas at Austin, Austin, TX, USA.
Wang N; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.
Person MD; Center for Biomedical Research Support, The University of Texas at Austin, Austin, TX, USA.
Iverson BL; Department of Chemistry, The University of Texas at Austin, Austin, TX, USA.
Gollihar JD; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.; CCDC Army Research Laboratory-South, The University of Texas at Austin, Austin, TX, USA.; Department of Pathology and Genomic Medicine, Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX, USA.
Dye JM; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD, USA.
Herbert AS; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD, USA.
Finkelstein IJ; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.
Baric RS; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
McLellan JS; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.
Georgiou G; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.; Department of Chemical Engineering, The University of Texas at Austin, Austin, TX, USA.; Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA.; Department of Oncology, Dell Medical School, The University of Texas at Austin, Austin, TX, USA.
Lavinder JJ; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA. .; Department of Chemical Engineering, The University of Texas at Austin, Austin, TX, USA.
Ippolito GC; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA. .; Department of Pathology and Genomic Medicine, Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX, USA.; Department of Oncology, Dell Medical School, The University of Texas at Austin, Austin, TX, USA.
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Źródło :
Science (New York, N.Y.) [Science] 2021 Jun 04; Vol. 372 (6546), pp. 1108-1112. Date of Electronic Publication: 2021 May 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Antibodies, Neutralizing/*immunology
Antibodies, Viral/*immunology
COVID-19/*immunology
Immunoglobulin G/*immunology
SARS-CoV-2/*immunology
Spike Glycoprotein, Coronavirus/*immunology
Animals ; Antibodies, Monoclonal/blood ; Antibodies, Monoclonal/chemistry ; Antibodies, Monoclonal/immunology ; Antibodies, Neutralizing/blood ; Antibodies, Neutralizing/chemistry ; Antibodies, Viral/blood ; Antibodies, Viral/chemistry ; Antibody Affinity ; COVID-19/prevention & control ; Epitopes/immunology ; Humans ; Immune Evasion ; Immunoglobulin G/blood ; Immunoglobulin G/chemistry ; Immunoglobulin Heavy Chains/immunology ; Immunoglobulin Variable Region/immunology ; Mice ; Mice, Inbred BALB C ; Mutation ; Protein Domains ; Proteomics ; SARS-CoV-2/genetics ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/genetics
SCR Organism :
SARS-CoV-2 variants
Czasopismo naukowe
Tytuł :
Structural insights into the cross-neutralization of SARS-CoV and SARS-CoV-2 by the human monoclonal antibody 47D11.
Autorzy :
Fedry J; Cryo-Electron Microscopy, Bijvoet Center for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Padualaan 8, 3584 CH Utrecht, Netherlands.
Hurdiss DL; Cryo-Electron Microscopy, Bijvoet Center for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Padualaan 8, 3584 CH Utrecht, Netherlands.; Virology Section, Infectious Diseases and Immunology Division, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, 3584 CL Utrecht, Netherlands.
Wang C; Virology Section, Infectious Diseases and Immunology Division, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, 3584 CL Utrecht, Netherlands.
Li W; Virology Section, Infectious Diseases and Immunology Division, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, 3584 CL Utrecht, Netherlands.
Obal G; Crystal and Structural Chemistry, Bijvoet Center for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Padualaan 8, 3584 CH Utrecht, Netherlands.
Drulyte I; Materials and Structural Analysis, Thermo Fisher Scientific, 5651 GG Eindhoven, Netherlands.
Du W; Virology Section, Infectious Diseases and Immunology Division, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, 3584 CL Utrecht, Netherlands.
Howes SC; Cryo-Electron Microscopy, Bijvoet Center for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Padualaan 8, 3584 CH Utrecht, Netherlands.
van Kuppeveld FJM; Virology Section, Infectious Diseases and Immunology Division, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, 3584 CL Utrecht, Netherlands.
Förster F; Cryo-Electron Microscopy, Bijvoet Center for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Padualaan 8, 3584 CH Utrecht, Netherlands. .
Bosch BJ; Virology Section, Infectious Diseases and Immunology Division, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, 3584 CL Utrecht, Netherlands. .
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Źródło :
Science advances [Sci Adv] 2021 Jun 02; Vol. 7 (23). Date of Electronic Publication: 2021 Jun 02 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Monoclonal*/chemistry
Antibodies, Monoclonal*/immunology
Antibodies, Neutralizing*/chemistry
Antibodies, Neutralizing*/immunology
Antibodies, Viral*/chemistry
Antibodies, Viral*/immunology
SARS Virus*/chemistry
SARS Virus*/immunology
SARS-CoV-2*/chemistry
SARS-CoV-2*/immunology
Humans ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Development of a SARS-CoV-2 nucleocapsid specific monoclonal antibody.
Autorzy :
Terry JS; Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA.
Anderson LB; Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA.
Scherman MS; Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA.
McAlister CE; Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA; Arthropod-borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA.
Perera R; Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA; Arthropod-borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA.
Schountz T; Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA; Arthropod-borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA.
Geiss BJ; Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA; Arthropod-borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA; School of Biomedical Engineering, Colorado State University, Fort Collins, CO, USA. Electronic address: .
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Źródło :
Virology [Virology] 2021 Jun; Vol. 558, pp. 28-37. Date of Electronic Publication: 2021 Feb 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Monoclonal*/immunology
Antibodies, Monoclonal*/isolation & purification
Antibodies, Viral*/immunology
Antibodies, Viral*/isolation & purification
COVID-19/*immunology
Coronavirus Nucleocapsid Proteins/*immunology
SARS-CoV-2/*immunology
Animals ; COVID-19/epidemiology ; Cloning, Molecular ; Escherichia coli ; Female ; Humans ; Mice ; Mice, Inbred BALB C ; Phosphoproteins/immunology ; Recombinant Proteins/immunology
Czasopismo naukowe
Tytuł :
High neutralizing potency of swine glyco-humanized polyclonal antibodies against SARS-CoV-2.
Autorzy :
Vanhove B; Xenothera, Nantes, France.
Duvaux O; Xenothera, Nantes, France.
Rousse J; Xenothera, Nantes, France.
Royer PJ; Xenothera, Nantes, France.
Evanno G; Xenothera, Nantes, France.
Ciron C; Xenothera, Nantes, France.
Lheriteau E; Xenothera, Nantes, France.
Vacher L; Xenothera, Nantes, France.
Gervois N; Inserm, CRCINA, Université de Nantes, Nantes, France.
Oger R; Inserm, CRCINA, Université de Nantes, Nantes, France.
Jacques Y; Inserm, CRCINA, Université de Nantes, Nantes, France.
Conchon S; CHU Nantes, Université de Nantes, Inserm, Centre de Recherche en Transplantation et Immunologie, Nantes, France.
Salama A; Xenothera, Nantes, France.
Duchi R; Avantea, Laboratorio di Tecnologie della Riproduzione, Cremona, Italy.
Lagutina I; Avantea, Laboratorio di Tecnologie della Riproduzione, Cremona, Italy.
Perota A; Avantea, Laboratorio di Tecnologie della Riproduzione, Cremona, Italy.
Delahaut P; CER Groupe, Marloie, Belgium.
Ledure M; CER Groupe, Marloie, Belgium.
Paulus M; CER Groupe, Marloie, Belgium.
So RT; HKU-Pasteur Research Pole, School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, P.R. China.
Mok CK; HKU-Pasteur Research Pole, School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, P.R. China.
Bruzzone R; HKU-Pasteur Research Pole, School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, P.R. China.; Department of Cell Biology and Infection, Institut Pasteur, Paris, France.
Bouillet M; Xenothera, Nantes, France.
Brouard S; CHU Nantes, Université de Nantes, Inserm, Centre de Recherche en Transplantation et Immunologie, Nantes, France.
Cozzi E; Transplantation Immunology Unit, Padua University Hospital, Padova, Italy.
Galli C; Avantea, Laboratorio di Tecnologie della Riproduzione, Cremona, Italy.
Blanchard D; Xenothera, Nantes, France.
Bach JM; IECM, Immuno-endocrinology, USC1383, Oniris, INRAE, Nantes, France.
Soulillou JP; CHU Nantes, Université de Nantes, Inserm, Centre de Recherche en Transplantation et Immunologie, Nantes, France.
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Źródło :
European journal of immunology [Eur J Immunol] 2021 Jun; Vol. 51 (6), pp. 1412-1422. Date of Electronic Publication: 2021 Mar 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Neutralizing/*immunology
Antibodies, Viral/*immunology
COVID-19/*immunology
COVID-19/*therapy
SARS-CoV-2/*immunology
Animals ; Animals, Genetically Modified/genetics ; Animals, Genetically Modified/immunology ; Antibodies, Neutralizing/genetics ; Antibodies, Neutralizing/pharmacology ; Antibodies, Viral/genetics ; Antibodies, Viral/pharmacology ; COVID-19/genetics ; Galactosyltransferases/deficiency ; Galactosyltransferases/immunology ; HEK293 Cells ; Humans ; Immunization, Passive ; SARS-CoV-2/genetics ; Sialic Acids/genetics ; Sialic Acids/immunology ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/immunology ; Swine
SCR Protocol :
COVID-19 serotherapy
Czasopismo naukowe
Tytuł :
Novel human neutralizing mAbs specific for Spike-RBD of SARS-CoV-2.
Autorzy :
Passariello M; Ceinge - Biotecnologie Avanzate s.c. a.r.l., Via Gaetano Salvatore 486, 80145, Naples, Italy.; Department of Molecular Medicine and Medical Biotechnology, University of Naples 'Federico II', Via Pansini 5, 80131, Napoli, NA, Italy.
Gentile C; Department of Molecular Medicine and Medical Biotechnology, University of Naples 'Federico II', Via Pansini 5, 80131, Napoli, NA, Italy.
Ferrucci V; Department of Molecular Medicine and Medical Biotechnology, University of Naples 'Federico II', Via Pansini 5, 80131, Napoli, NA, Italy.
Sasso E; Ceinge - Biotecnologie Avanzate s.c. a.r.l., Via Gaetano Salvatore 486, 80145, Naples, Italy.
Vetrei C; Department of Molecular Medicine and Medical Biotechnology, University of Naples 'Federico II', Via Pansini 5, 80131, Napoli, NA, Italy.
Fusco G; Istituto Zooprofilattico Sperimentale del Mezzogiorno, Via Salute 2, 80055, Portici Naples, Italy.
Viscardi M; Istituto Zooprofilattico Sperimentale del Mezzogiorno, Via Salute 2, 80055, Portici Naples, Italy.
Brandi S; Istituto Zooprofilattico Sperimentale del Mezzogiorno, Via Salute 2, 80055, Portici Naples, Italy.
Cerino P; Istituto Zooprofilattico Sperimentale del Mezzogiorno, Via Salute 2, 80055, Portici Naples, Italy.
Zambrano N; Ceinge - Biotecnologie Avanzate s.c. a.r.l., Via Gaetano Salvatore 486, 80145, Naples, Italy. .; Department of Molecular Medicine and Medical Biotechnology, University of Naples 'Federico II', Via Pansini 5, 80131, Napoli, NA, Italy. .
Zollo M; Ceinge - Biotecnologie Avanzate s.c. a.r.l., Via Gaetano Salvatore 486, 80145, Naples, Italy. .; Department of Molecular Medicine and Medical Biotechnology, University of Naples 'Federico II', Via Pansini 5, 80131, Napoli, NA, Italy. .
De Lorenzo C; Ceinge - Biotecnologie Avanzate s.c. a.r.l., Via Gaetano Salvatore 486, 80145, Naples, Italy. .; Department of Molecular Medicine and Medical Biotechnology, University of Naples 'Federico II', Via Pansini 5, 80131, Napoli, NA, Italy. .
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Źródło :
Scientific reports [Sci Rep] 2021 May 26; Vol. 11 (1), pp. 11046. Date of Electronic Publication: 2021 May 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Neutralizing/*metabolism
Antibodies, Viral/*metabolism
COVID-19/*therapy
Immunoglobulin G/*metabolism
Immunotherapy/*methods
SARS-CoV-2/*physiology
Spike Glycoprotein, Coronavirus/*metabolism
Angiotensin-Converting Enzyme 2/metabolism ; Antibodies, Monoclonal ; Antibodies, Neutralizing/genetics ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/genetics ; Antibodies, Viral/immunology ; COVID-19/immunology ; Cells, Cultured ; Epitopes ; Humans ; Immunoglobulin G/immunology ; Pandemics ; Protein Binding ; Protein Domains/genetics ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/immunology
Czasopismo naukowe
Tytuł :
A SARS-CoV-2 antibody curbs viral nucleocapsid protein-induced complement hyperactivation.
Autorzy :
Kang S; Molecular Imaging Center, Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China.
Yang M; Molecular Imaging Center, Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China.
He S; Molecular Imaging Center, Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China.
Wang Y; Institute of Biomedicine, Jinan University, Guangzhou, China.; Zhuhai Trinomab Biotechnology Co., Ltd, Zhuhai, China.
Chen X; Molecular Imaging Center, Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China.
Chen YQ; School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, China.
Hong Z; Department of Infectious Disease, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China.
Liu J; Department of Respiratory Disease, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China.
Jiang G; Department of Clinical laboratory, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, China.
Chen Q; Molecular Imaging Center, Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China.
Zhou Z; Molecular Imaging Center, Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China.
Zhou Z; Molecular Imaging Center, Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China.
Huang Z; Molecular Imaging Center, Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China.
Huang X; Center for Infection and Immunity, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China.
He H; Molecular Imaging Center, Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China.
Zheng W; Institute of Biomedicine, Jinan University, Guangzhou, China.; Zhuhai Trinomab Biotechnology Co., Ltd, Zhuhai, China.
Liao HX; Institute of Biomedicine, Jinan University, Guangzhou, China. .; Zhuhai Trinomab Biotechnology Co., Ltd, Zhuhai, China. .
Xiao F; Molecular Imaging Center, Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China. .; Department of Infectious Disease, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China. .
Shan H; Molecular Imaging Center, Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China. .; Department of Intervention Medicine, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China. .
Chen S; Molecular Imaging Center, Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China. .
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Źródło :
Nature communications [Nat Commun] 2021 May 11; Vol. 12 (1), pp. 2697. Date of Electronic Publication: 2021 May 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Viral/*pharmacology
COVID-19/*immunology
Complement Activation/*drug effects
Coronavirus Nucleocapsid Proteins/*immunology
SARS-CoV-2/*immunology
Allosteric Regulation ; Antibodies, Monoclonal/chemistry ; Antibodies, Monoclonal/immunology ; Antibodies, Viral/chemistry ; Antibodies, Viral/immunology ; Antibody Affinity ; Antigen-Antibody Complex/chemistry ; Convalescence ; Coronavirus Nucleocapsid Proteins/chemistry ; Crystallography, X-Ray ; Epitopes ; Humans ; Phosphoproteins/chemistry ; Phosphoproteins/immunology ; Protein Conformation
Czasopismo naukowe
Tytuł :
Nanobody cocktails potently neutralize SARS-CoV-2 D614G N501Y variant and protect mice.
Autorzy :
Pymm P; Infectious Diseases and Immune Defences Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC 3010, Australia.
Adair A; Infectious Diseases and Immune Defences Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.
Chan LJ; Infectious Diseases and Immune Defences Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC 3010, Australia.
Cooney JP; Infectious Diseases and Immune Defences Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC 3010, Australia.
Mordant FL; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC 3000, Australia.
Allison CC; Infectious Diseases and Immune Defences Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC 3010, Australia.
Lopez E; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC 3000, Australia.
Haycroft ER; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC 3000, Australia.
O'Neill MT; Infectious Diseases and Immune Defences Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.
Tan LL; Infectious Diseases and Immune Defences Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.
Dietrich MH; Infectious Diseases and Immune Defences Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC 3010, Australia.
Drew D; Infectious Diseases and Immune Defences Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.
Doerflinger M; Infectious Diseases and Immune Defences Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC 3010, Australia.
Dengler MA; Infectious Diseases and Immune Defences Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC 3010, Australia.
Scott NE; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC 3000, Australia.
Wheatley AK; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC 3000, Australia.; Australian Research Council Centre for Excellence in Convergent Bio-Nano Science and Technology, University of Melbourne, Melbourne, VIC 3010, Australia.
Gherardin NA; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC 3000, Australia.; Australian Research Council Centre of Excellence in Advanced Molecular Imaging, University of Melbourne, Melbourne, VIC 3010, Australia.
Venugopal H; Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia.
Cromer D; Kirby Institute, University of New South Wales, Sydney, NSW 2052, Australia.; Department of Mathematics and Statistics, University of New South Wales, Sydney, NSW 2052, Australia.
Davenport MP; Kirby Institute, University of New South Wales, Sydney, NSW 2052, Australia.
Pickering R; Department of Diabetes, Central Clinical School, Monash University, Melbourne, VIC 3004, Australia.
Godfrey DI; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC 3000, Australia.; Australian Research Council Centre of Excellence in Advanced Molecular Imaging, University of Melbourne, Melbourne, VIC 3010, Australia.
Purcell DFJ; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC 3000, Australia.
Kent SJ; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC 3000, Australia.; Australian Research Council Centre for Excellence in Convergent Bio-Nano Science and Technology, University of Melbourne, Melbourne, VIC 3010, Australia.
Chung AW; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC 3000, Australia.
Subbarao K; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC 3000, Australia.; WHO Collaborating Centre for Reference and Research on Influenza, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC 3000, Australia.
Pellegrini M; Infectious Diseases and Immune Defences Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC 3010, Australia.
Glukhova A; Infectious Diseases and Immune Defences Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.; Drug Discovery Biology, Monash Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.; Department of Biochemistry and Pharmacology, University of Melbourne, Melbourne, VIC 3010, Australia.
Tham WH; Infectious Diseases and Immune Defences Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; .; Department of Medical Biology, University of Melbourne, Melbourne, VIC 3010, Australia.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 May 11; Vol. 118 (19).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Neutralizing*/immunology
Antibodies, Neutralizing*/pharmacology
Antibodies, Viral*/immunology
Antibodies, Viral*/pharmacology
COVID-19*/drug therapy
COVID-19*/immunology
Single-Domain Antibodies*/immunology
Single-Domain Antibodies*/pharmacology
SARS-CoV-2/*immunology
Angiotensin-Converting Enzyme 2/immunology ; Animals ; Camelids, New World ; Humans ; Mice
SCR Organism :
SARS-CoV-2 variants
Czasopismo naukowe
Tytuł :
SARS-CoV-2 spike therapeutic antibodies in the age of variants.
Autorzy :
Baum A; Regeneron Pharmaceuticals Inc., Tarrytown, NY.
Kyratsous CA; Regeneron Pharmaceuticals Inc., Tarrytown, NY.
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Źródło :
The Journal of experimental medicine [J Exp Med] 2021 May 03; Vol. 218 (5).
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antibodies, Viral*/immunology
Antibodies, Viral*/therapeutic use
Aging/*immunology
COVID-19/*immunology
COVID-19/*therapy
SARS-CoV-2/*immunology
Spike Glycoprotein, Coronavirus/*immunology
Humans ; Immunization, Passive
SCR Protocol :
COVID-19 serotherapy
Czasopismo naukowe
Tytuł :
COVID-19 Severity Is Associated with Differential Antibody Fc-Mediated Innate Immune Functions.
Autorzy :
Adeniji OS; The Wistar Institute, Philadelphia, Pennsylvania, USA.
Giron LB; The Wistar Institute, Philadelphia, Pennsylvania, USA.
Purwar M; The Wistar Institute, Philadelphia, Pennsylvania, USA.
Zilberstein NF; Rush University, Chicago, Illinois, USA.
Kulkarni AJ; The Wistar Institute, Philadelphia, Pennsylvania, USA.
Shaikh MW; Rush University, Chicago, Illinois, USA.
Balk RA; Rush University, Chicago, Illinois, USA.
Moy JN; Rush University, Chicago, Illinois, USA.
Forsyth CB; Rush University, Chicago, Illinois, USA.
Liu Q; The Wistar Institute, Philadelphia, Pennsylvania, USA.
Dweep H; The Wistar Institute, Philadelphia, Pennsylvania, USA.
Kossenkov A; The Wistar Institute, Philadelphia, Pennsylvania, USA.
Weiner DB; The Wistar Institute, Philadelphia, Pennsylvania, USA.
Keshavarzian A; Rush University, Chicago, Illinois, USA.
Landay A; Rush University, Chicago, Illinois, USA.
Abdel-Mohsen M; The Wistar Institute, Philadelphia, Pennsylvania, USA .
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Źródło :
MBio [mBio] 2021 Apr 20; Vol. 12 (2). Date of Electronic Publication: 2021 Apr 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Viral*/blood
Antibodies, Viral*/immunology
Immunity, Innate*
COVID-19/*immunology
SARS-CoV-2/*immunology
Antibodies, Neutralizing/blood ; Antibody Specificity ; Antibody-Dependent Cell Cytotoxicity ; Biomarkers/blood ; COVID-19/etiology ; COVID-19/virology ; Case-Control Studies ; Cohort Studies ; Complement Activation ; Female ; Humans ; Immunoglobulin Fc Fragments/immunology ; Inflammation/blood ; Inflammation/etiology ; Inflammation/immunology ; Male ; Middle Aged ; Pandemics ; Phagocytosis ; Receptors, Fc/immunology ; Severity of Illness Index ; Spike Glycoprotein, Coronavirus/immunology
Czasopismo naukowe
Tytuł :
Modular basis for potent SARS-CoV-2 neutralization by a prevalent VH1-2-derived antibody class.
Autorzy :
Rapp M; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA.
Guo Y; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA.
Reddem ER; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA.
Yu J; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA.
Liu L; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA.
Wang P; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA.
Cerutti G; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA.
Katsamba P; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA.
Bimela JS; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA.
Bahna FA; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA.
Mannepalli SM; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA.
Zhang B; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Kwong PD; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Huang Y; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA.
Ho DD; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA.
Shapiro L; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: .
Sheng Z; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA. Electronic address: .
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Źródło :
Cell reports [Cell Rep] 2021 Apr 06; Vol. 35 (1), pp. 108950. Date of Electronic Publication: 2021 Mar 19.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Antibodies, Neutralizing*/genetics
Antibodies, Neutralizing*/immunology
Antibodies, Viral*/genetics
Antibodies, Viral*/immunology
COVID-19*/genetics
COVID-19*/immunology
Immunoglobulin Variable Region*/genetics
Immunoglobulin Variable Region*/immunology
SARS-CoV-2/*immunology
HEK293 Cells ; Humans
Czasopismo naukowe
Tytuł :
Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions for optimal therapeutic protection.
Autorzy :
Winkler ES; Department of Medicine, Washington University School of Medicine, St. Louis, St. Louis, MO 63110, USA; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, St. Louis, MO 63110, USA.
Gilchuk P; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Yu J; Department of Genetics, Washington University School of Medicine, St. Louis, St. Louis, MO 63110, USA.
Bailey AL; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, St. Louis, MO 63110, USA.
Chen RE; Department of Medicine, Washington University School of Medicine, St. Louis, St. Louis, MO 63110, USA; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, St. Louis, MO 63110, USA.
Chong Z; Department of Medicine, Washington University School of Medicine, St. Louis, St. Louis, MO 63110, USA.
Zost SJ; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Jang H; Center for Vaccines and Immunology, University of Georgia, Athens, GA 30605, USA.
Huang Y; Center for Vaccines and Immunology, University of Georgia, Athens, GA 30605, USA.
Allen JD; Center for Vaccines and Immunology, University of Georgia, Athens, GA 30605, USA.
Case JB; Department of Medicine, Washington University School of Medicine, St. Louis, St. Louis, MO 63110, USA.
Sutton RE; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Carnahan RH; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Darling TL; Department of Medicine, Washington University School of Medicine, St. Louis, St. Louis, MO 63110, USA.
Boon ACM; Department of Medicine, Washington University School of Medicine, St. Louis, St. Louis, MO 63110, USA; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, St. Louis, MO 63110, USA; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, St. Louis, MO 63110, USA.
Mack M; Department of Internal Medicine II, University Hospital Regensburg, 93053 Regensburg, Germany.
Head RD; Department of Genetics, Washington University School of Medicine, St. Louis, St. Louis, MO 63110, USA.
Ross TM; Center for Vaccines and Immunology, University of Georgia, Athens, GA 30605, USA.
Crowe JE Jr; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA. Electronic address: .
Diamond MS; Department of Medicine, Washington University School of Medicine, St. Louis, St. Louis, MO 63110, USA; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, St. Louis, MO 63110, USA; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, St. Louis, MO 63110, USA; The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, St. Louis, MO 63110, USA. Electronic address: .
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Źródło :
Cell [Cell] 2021 Apr 01; Vol. 184 (7), pp. 1804-1820.e16. Date of Electronic Publication: 2021 Feb 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Monoclonal*/immunology
Antibodies, Monoclonal*/therapeutic use
Antibodies, Neutralizing*/immunology
Antibodies, Neutralizing*/therapeutic use
Antibodies, Viral*/immunology
Antibodies, Viral*/therapeutic use
CD8-Positive T-Lymphocytes*/cytology
CD8-Positive T-Lymphocytes*/immunology
COVID-19*/immunology
COVID-19*/therapy
Immunoglobulin Fc Fragments/*immunology
Animals ; CHO Cells ; Chlorocebus aethiops ; Cricetulus ; Disease Models, Animal ; Female ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; SARS-CoV-2/immunology ; Vero Cells ; Viral Load
Czasopismo naukowe
Tytuł :
Seasonal human coronavirus antibodies are boosted upon SARS-CoV-2 infection but not associated with protection.
Autorzy :
Anderson EM; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Goodwin EC; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Verma A; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Arevalo CP; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Bolton MJ; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Weirick ME; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Gouma S; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
McAllister CM; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Christensen SR; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Weaver J; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Hicks P; School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Manzoni TB; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Oniyide O; Division of Pulmonary, Allergy, and Critical Care Medicine and Center for Translational Lung Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
Ramage H; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Mathew D; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.
Baxter AE; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.
Oldridge DA; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.
Greenplate AR; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.
Wu JE; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA; Parker Institute for Cancer Immunotherapy, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Alanio C; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA; Parker Institute for Cancer Immunotherapy, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
D'Andrea K; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.
Kuthuru O; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.
Dougherty J; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.
Pattekar A; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.
Kim J; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.
Han N; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.
Apostolidis SA; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.
Huang AC; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.
Vella LA; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA; Division of Infectious Diseases, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Kuri-Cervantes L; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Pampena MB; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Betts MR; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Wherry EJ; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA; Parker Institute for Cancer Immunotherapy, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Meyer NJ; Division of Pulmonary, Allergy, and Critical Care Medicine and Center for Translational Lung Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
Cherry S; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Bates P; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Penn Center for Research on Coronavirus and Other Emerging Pathogens, University of Pennsylvania, Philadelphia, PA 19104, USA.
Rader DJ; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Hensley SE; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: .
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Corporate Authors :
UPenn COVID Processing Unit
Źródło :
Cell [Cell] 2021 Apr 01; Vol. 184 (7), pp. 1858-1864.e10. Date of Electronic Publication: 2021 Feb 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Viral*/blood
Antibodies, Viral*/immunology
Alphacoronavirus/*immunology
Betacoronavirus/*immunology
COVID-19/*immunology
Adolescent ; Adult ; Animals ; COVID-19 Serological Testing ; Child ; Child, Preschool ; Chlorocebus aethiops ; Cross Protection ; Cross Reactions ; Disease Susceptibility ; HEK293 Cells ; Humans ; Infant ; Infant, Newborn ; Vero Cells
Czasopismo naukowe
Tytuł :
Longitudinal antibody and T cell responses in Ebola virus disease survivors and contacts: an observational cohort study.
Autorzy :
Thom R; National Infection Service, Public Health England, Porton Down, UK.
Tipton T; National Infection Service, Public Health England, Porton Down, UK.
Strecker T; Institute of Virology, Philipps University of Marburg, Marburg, Germany.
Hall Y; National Infection Service, Public Health England, Porton Down, UK.
Akoi Bore J; Center for Training and Research on Priority Diseases including Malaria in Guinea, Conakry, Guinea; Ministry of Health Guinea, Conakry, Guinea.
Maes P; Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Raymond Koundouno F; Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany; Ministry of Health Guinea, Conakry, Guinea.
Fehling SK; Institute of Virology, Philipps University of Marburg, Marburg, Germany.
Krähling V; Institute of Virology, Philipps University of Marburg, Marburg, Germany; German Center for Infection Research, Partner Site Gießen-Marburg-Langen, Marburg, Germany.
Steeds K; National Infection Service, Public Health England, Porton Down, UK.
Varghese A; National Infection Service, Public Health England, Porton Down, UK.
Bailey G; Biodiscovery Institute, School of Medicine, University of Nottingham, UK.
Matheson M; National Infection Service, Public Health England, Porton Down, UK.
Kouyate S; Center for Training and Research on Priority Diseases including Malaria in Guinea, Conakry, Guinea.
Coné M; Center for Training and Research on Priority Diseases including Malaria in Guinea, Conakry, Guinea.
Moussa Keita B; Center for Training and Research on Priority Diseases including Malaria in Guinea, Conakry, Guinea.
Kouyate S; Center for Training and Research on Priority Diseases including Malaria in Guinea, Conakry, Guinea.
Richard Ablam A; Center for Training and Research on Priority Diseases including Malaria in Guinea, Conakry, Guinea.
Laenen L; Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Vergote V; Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Guiver M; Public Health Laboratory, National Infection Service, Public Health England, Manchester Royal Infirmary, Manchester, UK.
Timothy J; Department of Disease Control, London School of Hygiene and Tropical Medicine, London, UK.
Atkinson B; National Infection Service, Public Health England, Porton Down, UK.
Ottowell L; National Infection Service, Public Health England, Porton Down, UK.
Richards KS; National Infection Service, Public Health England, Porton Down, UK.
Bosworth A; National Infection Service, Public Health England, Porton Down, UK.
Longet S; National Infection Service, Public Health England, Porton Down, UK.
Mellors J; National Infection Service, Public Health England, Porton Down, UK; Department of Infection Biology, Institute of Infection and Global Health, University of Liverpool, Liverpool, UK.
Pannetier D; P4 Jean Mérieux-Inserm Laboratory, Lyon, France.
Duraffour S; Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany; German Center for Infection Research, Partner Site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany.
Muñoz-Fontela C; Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany; German Center for Infection Research, Partner Site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany.
Sow O; National Ethics Committee for Health Research, Conakry, Guinea.
Koivogui L; Ministry of Health Guinea, Conakry, Guinea.
Newman E; National Infection Service, Public Health England, Porton Down, UK.
Becker S; Institute of Virology, Philipps University of Marburg, Marburg, Germany; German Center for Infection Research, Partner Site Gießen-Marburg-Langen, Marburg, Germany.
Sprecher A; Medecins San Frontieres Brussels, Brussels, Belgium.
Raoul H; P4 Jean Mérieux-Inserm Laboratory, Lyon, France.
Hiscox J; Department of Infection Biology, Institute of Infection and Global Health, University of Liverpool, Liverpool, UK.
Henao-Restrepo AM; World Health Organization, Geneva, Switzerland.
Sakoba K; Projet Laboratoire Fièvres Hémorragiques, Conakry, Guinea.
Magassouba N; Projet Laboratoire Fièvres Hémorragiques, Conakry, Guinea.
Günther S; Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany; German Center for Infection Research, Partner Site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany.
Kader Konde M; Center for Training and Research on Priority Diseases including Malaria in Guinea, Conakry, Guinea.
Carroll MW; National Infection Service, Public Health England, Porton Down, UK; Nuffield Department of Medicine, University of Oxford, Oxford, UK. Electronic address: .
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Źródło :
The Lancet. Infectious diseases [Lancet Infect Dis] 2021 Apr; Vol. 21 (4), pp. 507-516. Date of Electronic Publication: 2020 Oct 13.
Typ publikacji :
Journal Article; Observational Study; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Antibodies, Viral/*blood
Ebolavirus/*immunology
Hemorrhagic Fever, Ebola/*immunology
Survivors/*statistics & numerical data
T-Lymphocytes/*immunology
Adolescent ; Adult ; Antibodies, Viral/immunology ; Antibodies, Viral/isolation & purification ; Child ; Child, Preschool ; Ebolavirus/pathogenicity ; Epidemics ; Female ; Guinea/epidemiology ; Hemorrhagic Fever, Ebola/blood ; Hemorrhagic Fever, Ebola/transmission ; Hemorrhagic Fever, Ebola/virology ; Humans ; Immunity, Cellular ; Immunity, Humoral ; Infant ; Infant, Newborn ; Longitudinal Studies ; Male ; Middle Aged ; Time Factors ; Young Adult
Czasopismo naukowe
Tytuł :
Cross-Reactive Neutralizing Antibody Responses Elicited by SARS-CoV-2 501Y.V2 (B.1.351).
Autorzy :
Moyo-Gwete T; National Institute for Communicable Diseases, Johannesburg, South Africa.
Madzivhandila M; National Institute for Communicable Diseases, Johannesburg, South Africa.
Makhado Z; National Institute for Communicable Diseases, Johannesburg, South Africa.
Ayres F; National Institute for Communicable Diseases, Johannesburg, South Africa.
Mhlanga D; National Institute for Communicable Diseases, Johannesburg, South Africa.
Oosthuysen B; National Institute for Communicable Diseases, Johannesburg, South Africa.
Lambson BE; National Institute for Communicable Diseases, Johannesburg, South Africa.
Kgagudi P; National Institute for Communicable Diseases, Johannesburg, South Africa.
Tegally H; KwaZulu-Natal Research Innovation and Sequencing Platform, Durban, South Africa.
Iranzadeh A; University of Cape Town, Cape Town, South Africa.
Doolabh D; University of Cape Town, Cape Town, South Africa.
Tyers L; University of Cape Town, Cape Town, South Africa.
Chinhoyi LR; University of Cape Town, Cape Town, South Africa.
Mennen M; University of Cape Town, Cape Town, South Africa.
Skelem S; University of Cape Town, Cape Town, South Africa.
Marais G; University of Cape Town, Cape Town, South Africa.
Wibmer CK; National Institute for Communicable Diseases, Johannesburg, South Africa.
Bhiman JN; National Institute for Communicable Diseases, Johannesburg, South Africa.
Ueckermann V; Steve Biko Academic Hospital, Pretoria, South Africa.
Rossouw T; University of Pretoria, Pretoria, South Africa.
Boswell M; Steve Biko Academic Hospital, Pretoria, South Africa.
de Oliveira T; KwaZulu-Natal Research Innovation and Sequencing Platform, Durban, South Africa.
Williamson C; University of Cape Town, Cape Town, South Africa.
Burgers WA; University of Cape Town, Cape Town, South Africa.
Ntusi N; University of Cape Town, Cape Town, South Africa.
Morris L; National Institute for Communicable Diseases, Johannesburg, South Africa .
Moore PL; National Institute for Communicable Diseases, Johannesburg, South Africa .
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Źródło :
The New England journal of medicine [N Engl J Med] 2021 Jun 03; Vol. 384 (22), pp. 2161-2163. Date of Electronic Publication: 2021 Apr 07.
Typ publikacji :
Letter
MeSH Terms :
Antibodies, Neutralizing/*blood
Antibodies, Viral/*blood
COVID-19/*immunology
COVID-19 Vaccines/*immunology
SARS-CoV-2/*immunology
Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology ; COVID-19/blood ; COVID-19/virology ; Cross Reactions ; Humans ; Neutralization Tests ; Spike Glycoprotein, Coronavirus/immunology
SCR Organism :
SARS-CoV-2 variants
Opinia redakcyjna
Tytuł :
NMR Based SARS-CoV-2 Antibody Screening.
Autorzy :
Schoenle MV; Biochemistry Graduate Program, University of Arizona, Tucson, Arizona 85721, United States.
Li Y; Department of Molecular Biology and Biophysics, University of Connecticut Health Center, Farmington, Connecticut 06030, United States.
Yuan M; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California 92037, United States.
Clarkson MW; Deparment of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona 85721, United States.
Wilson IA; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California 92037, United States.; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92037, United States.
Peti W; Department of Molecular Biology and Biophysics, University of Connecticut Health Center, Farmington, Connecticut 06030, United States.
Page R; Department of Cell Biology, University of Connecticut Health Center, Farmington, Connecticut 06030, United States.
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Źródło :
Journal of the American Chemical Society [J Am Chem Soc] 2021 Jun 02; Vol. 143 (21), pp. 7930-7934. Date of Electronic Publication: 2021 May 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Angiotensin-Converting Enzyme 2/*chemistry
Antibodies, Monoclonal/*chemistry
Antibodies, Viral/*chemistry
COVID-19/*metabolism
SARS-CoV-2/*metabolism
Spike Glycoprotein, Coronavirus/*chemistry
Amino Acid Sequence ; Angiotensin-Converting Enzyme 2/metabolism ; Antibodies, Monoclonal/metabolism ; Antibodies, Viral/metabolism ; Binding Sites ; Epitopes/chemistry ; Humans ; Nuclear Magnetic Resonance, Biomolecular ; Protein Binding ; Protein Domains ; Spike Glycoprotein, Coronavirus/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Characterization of the SARS-CoV-2 Neutralization Potential of COVID-19-Convalescent Donors.
Autorzy :
Jahrsdörfer B; Department of Transfusion Medicine, Ulm University, Ulm, Germany; .; Institute for Clinical Transfusion Medicine and Immunogenetics, German Red Cross Blood Transfusion Service Baden-Württemberg-Hessen and University Hospital Ulm, Ulm, Germany.
Groß R; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany.
Seidel A; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany.
Wettstein L; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany.
Ludwig C; Department of Transfusion Medicine, Ulm University, Ulm, Germany.; Institute for Clinical Transfusion Medicine and Immunogenetics, German Red Cross Blood Transfusion Service Baden-Württemberg-Hessen and University Hospital Ulm, Ulm, Germany.
Schwarz T; Institute of Virology, Charité Universitätsmedizin Berlin, Berlin, Germany; and.
Körper S; Department of Transfusion Medicine, Ulm University, Ulm, Germany.; Institute for Clinical Transfusion Medicine and Immunogenetics, German Red Cross Blood Transfusion Service Baden-Württemberg-Hessen and University Hospital Ulm, Ulm, Germany.
Rojewski M; Department of Transfusion Medicine, Ulm University, Ulm, Germany.; Institute for Clinical Transfusion Medicine and Immunogenetics, German Red Cross Blood Transfusion Service Baden-Württemberg-Hessen and University Hospital Ulm, Ulm, Germany.
Lotfi R; Department of Transfusion Medicine, Ulm University, Ulm, Germany.; Institute for Clinical Transfusion Medicine and Immunogenetics, German Red Cross Blood Transfusion Service Baden-Württemberg-Hessen and University Hospital Ulm, Ulm, Germany.
Weinstock C; Department of Transfusion Medicine, Ulm University, Ulm, Germany.; Institute for Clinical Transfusion Medicine and Immunogenetics, German Red Cross Blood Transfusion Service Baden-Württemberg-Hessen and University Hospital Ulm, Ulm, Germany.
Seifried E; Institute of Transfusion Medicine and Immunohematology, German Red Cross Blood Transfusion Service Baden-Württemberg-Hessen, Frankfurt, Germany.
Corman VM; Institute of Virology, Charité Universitätsmedizin Berlin, Berlin, Germany; and.
Drosten C; Institute of Virology, Charité Universitätsmedizin Berlin, Berlin, Germany; and.
Münch J; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany.
Schrezenmeier H; Department of Transfusion Medicine, Ulm University, Ulm, Germany.; Institute for Clinical Transfusion Medicine and Immunogenetics, German Red Cross Blood Transfusion Service Baden-Württemberg-Hessen and University Hospital Ulm, Ulm, Germany.
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Źródło :
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2021 Jun 01; Vol. 206 (11), pp. 2614-2622. Date of Electronic Publication: 2021 May 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Blood Donors*
Antibodies, Neutralizing/*immunology
Antibodies, Viral/*immunology
COVID-19/*therapy
SARS-CoV-2/*immunology
Antibodies, Neutralizing/therapeutic use ; Antibodies, Viral/therapeutic use ; COVID-19/immunology ; Female ; Humans ; Immunization, Passive ; Male ; Rh-Hr Blood-Group System/immunology
SCR Protocol :
COVID-19 serotherapy
Czasopismo naukowe
Tytuł :
Quantification of SARS-CoV-2 neutralizing antibody by wild-type plaque reduction neutralization, microneutralization and pseudotyped virus neutralization assays.
Autorzy :
Bewley KR; National Infection Service, Public Health England, Salisbury, UK. .
Coombes NS; National Infection Service, Public Health England, Salisbury, UK.
Gagnon L; Nexelis, Laval, Quebec, Canada.
McInroy L; National Infection Service, Public Health England, Salisbury, UK.
Baker N; National Infection Service, Public Health England, Salisbury, UK.
Shaik I; National Infection Service, Public Health England, Salisbury, UK.
St-Jean JR; Nexelis, Laval, Quebec, Canada.
St-Amant N; Nexelis, Laval, Quebec, Canada.
Buttigieg KR; National Infection Service, Public Health England, Salisbury, UK.
Humphries HE; National Infection Service, Public Health England, Salisbury, UK.
Godwin KJ; National Infection Service, Public Health England, Salisbury, UK.
Brunt E; National Infection Service, Public Health England, Salisbury, UK.
Allen L; National Infection Service, Public Health England, Salisbury, UK.
Leung S; National Infection Service, Public Health England, Salisbury, UK.
Brown PJ; National Infection Service, Public Health England, Salisbury, UK.
Penn EJ; National Infection Service, Public Health England, Salisbury, UK.
Thomas K; National Infection Service, Public Health England, Salisbury, UK.
Kulnis G; Nexelis, Laval, Quebec, Canada.
Hallis B; National Infection Service, Public Health England, Salisbury, UK.
Carroll M; National Infection Service, Public Health England, Salisbury, UK.
Funnell S; National Infection Service, Public Health England, Salisbury, UK.
Charlton S; National Infection Service, Public Health England, Salisbury, UK.
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Źródło :
Nature protocols [Nat Protoc] 2021 Jun; Vol. 16 (6), pp. 3114-3140. Date of Electronic Publication: 2021 Apr 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Neutralizing/*immunology
Antibodies, Viral/*immunology
COVID-19/*immunology
Neutralization Tests/*methods
SARS-CoV-2/*immunology
Antibodies, Neutralizing/blood ; Antibodies, Viral/blood ; COVID-19/blood ; COVID-19/prevention & control ; COVID-19 Vaccines/immunology ; COVID-19 Vaccines/therapeutic use ; Humans ; Neutralization Tests/economics ; Time Factors
Czasopismo naukowe
Tytuł :
Automated Western immunoblotting detection of anti-SARS-CoV-2 serum antibodies.
Autorzy :
Edouard S; IHU-Méditerranée Infection, 19-21 Boulevard Jean Moulin, 13005, Marseille, France.; Aix Marseille Univ., IRD, AP-HM, MEPHI, Marseille, France.
Jaafar R; IHU-Méditerranée Infection, 19-21 Boulevard Jean Moulin, 13005, Marseille, France.; Aix Marseille Univ., IRD, AP-HM, MEPHI, Marseille, France.
Orain N; IHU-Méditerranée Infection, 19-21 Boulevard Jean Moulin, 13005, Marseille, France.
Parola P; IHU-Méditerranée Infection, 19-21 Boulevard Jean Moulin, 13005, Marseille, France.; Aix Marseille Univ., IRD, AP-HM, SSA, VITROME, Marseille, France.
Colson P; IHU-Méditerranée Infection, 19-21 Boulevard Jean Moulin, 13005, Marseille, France.; Aix Marseille Univ., IRD, AP-HM, MEPHI, Marseille, France.
La Scola B; IHU-Méditerranée Infection, 19-21 Boulevard Jean Moulin, 13005, Marseille, France.; Aix Marseille Univ., IRD, AP-HM, MEPHI, Marseille, France.
Fournier PE; IHU-Méditerranée Infection, 19-21 Boulevard Jean Moulin, 13005, Marseille, France.; Aix Marseille Univ., IRD, AP-HM, SSA, VITROME, Marseille, France.
Raoult D; IHU-Méditerranée Infection, 19-21 Boulevard Jean Moulin, 13005, Marseille, France.; Aix Marseille Univ., IRD, AP-HM, MEPHI, Marseille, France.
Drancourt M; IHU-Méditerranée Infection, 19-21 Boulevard Jean Moulin, 13005, Marseille, France. .; Aix Marseille Univ., IRD, AP-HM, MEPHI, Marseille, France. .
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Źródło :
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology [Eur J Clin Microbiol Infect Dis] 2021 Jun; Vol. 40 (6), pp. 1309-1317. Date of Electronic Publication: 2021 Mar 03.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Blotting, Western*
Antibodies, Viral/*isolation & purification
COVID-19/*diagnosis
Antibodies, Viral/blood ; Automation, Laboratory ; Coronavirus Nucleocapsid Proteins/immunology ; Cross Reactions ; Enzyme-Linked Immunosorbent Assay ; Humans ; Phosphoproteins/immunology ; SARS-CoV-2/immunology ; Sensitivity and Specificity ; Spike Glycoprotein, Coronavirus/immunology
Czasopismo naukowe

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