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Tytuł :
Safety of Intravenous Push Lacosamide Compared With Intravenous Piggyback at a Tertiary Academic Medical Center.
Autorzy :
McLaughlin K; Brigham and Women's Hospital, Boston, MA, USA.
Carabetta S; St. Vincent's HealthCare, Jacksonville, FL, USA.
Hunt N; Brigham and Women's Hospital, Boston, MA, USA.
Schuler BR; Brigham and Women's Hospital, Boston, MA, USA.
Ting C; Brigham and Women's Hospital, Boston, MA, USA.
Tran LK; Brigham and Women's Hospital, Boston, MA, USA.
Szumita PM; Brigham and Women's Hospital, Boston, MA, USA.
Anger KE; Brigham and Women's Hospital, Boston, MA, USA.
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Źródło :
The Annals of pharmacotherapy [Ann Pharmacother] 2021 Feb; Vol. 55 (2), pp. 181-186. Date of Electronic Publication: 2020 Jul 19.
Typ publikacji :
Journal Article
MeSH Terms :
Anticonvulsants/*administration & dosage
Anticonvulsants/*adverse effects
Lacosamide/*administration & dosage
Lacosamide/*adverse effects
Academic Medical Centers ; Adult ; Anticonvulsants/therapeutic use ; Bradycardia/chemically induced ; Bradycardia/epidemiology ; Cohort Studies ; Conscious Sedation ; Female ; Humans ; Hypotension/chemically induced ; Hypotension/epidemiology ; Incidence ; Infusions, Intravenous ; Injections, Intravenous ; Lacosamide/therapeutic use ; Male ; Middle Aged ; Retrospective Studies ; Tertiary Care Centers
Czasopismo naukowe
Tytuł :
Anticonvulsant Effects of Topiramate and Lacosamide on Pilocarpine-Induced Status Epilepticus in Rats: A Role of Reactive Oxygen Species and Inflammation.
Autorzy :
Shishmanova-Doseva M; Department of Pharmacology and Drug Toxicology, Medical University-Plovdiv, 4002 Plovdiv, Bulgaria.
Peychev L; Department of Pharmacology and Drug Toxicology, Medical University-Plovdiv, 4002 Plovdiv, Bulgaria.
Yoanidu L; Department of Bioorganic Chemistry, Medical University-Plovdiv, 4002 Plovdiv, Bulgaria.
Uzunova Y; Department of Bioorganic Chemistry, Medical University-Plovdiv, 4002 Plovdiv, Bulgaria.
Atanasova M; Department of Biology, Medical University of Pleven, 5800 Pleven, Bulgaria.
Georgieva K; Department of Physiology, Medical University-Plovdiv, 4002 Plovdiv, Bulgaria.
Tchekalarova J; Institute of Neurobiology, Bulgarian Academy of Sciences (BAS), 1113 Sofia, Bulgaria.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Feb 25; Vol. 22 (5). Date of Electronic Publication: 2021 Feb 25.
Typ publikacji :
Journal Article
MeSH Terms :
Anticonvulsants/*therapeutic use
Inflammation/*pathology
Lacosamide/*therapeutic use
Reactive Oxygen Species/*metabolism
Status Epilepticus/*chemically induced
Status Epilepticus/*drug therapy
Topiramate/*therapeutic use
Animals ; Anticonvulsants/pharmacology ; Biomarkers/metabolism ; Hippocampus/drug effects ; Hippocampus/pathology ; Hippocampus/physiopathology ; Interleukin-1beta/metabolism ; Lacosamide/pharmacology ; Male ; Motor Activity/drug effects ; Oxidative Stress/drug effects ; Pilocarpine ; Rats, Wistar ; Seizures/physiopathology ; Status Epilepticus/physiopathology ; Topiramate/pharmacology ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe
Tytuł :
Opportunities, Challenges and Pitfalls of Using Cannabidiol as an Adjuvant Drug in COVID-19.
Autorzy :
Malinowska B; Department of Experimental Physiology and Pathophysiology, Medical University of Białystok, 15-222 Białystok, Poland.
Baranowska-Kuczko M; Department of Experimental Physiology and Pathophysiology, Medical University of Białystok, 15-222 Białystok, Poland.; Department of Clinical Pharmacy, Medical University of Białystok, 15-222 Białystok, Poland.
Kicman A; Department of Experimental Physiology and Pathophysiology, Medical University of Białystok, 15-222 Białystok, Poland.
Schlicker E; Department of Pharmacology and Toxicology, University of Bonn, 53127 Bonn, Germany.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Feb 17; Vol. 22 (4). Date of Electronic Publication: 2021 Feb 17.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Analgesics/*therapeutic use
Anticonvulsants/*therapeutic use
Antiviral Agents/*therapeutic use
COVID-19/*drug therapy
Cannabidiol/*therapeutic use
Analgesics/adverse effects ; Analgesics/pharmacology ; Animals ; Anticonvulsants/adverse effects ; Anticonvulsants/pharmacology ; Antiviral Agents/adverse effects ; Antiviral Agents/pharmacology ; Cannabidiol/adverse effects ; Cannabidiol/pharmacology ; Dronabinol/adverse effects ; Dronabinol/pharmacology ; Dronabinol/therapeutic use ; Humans ; SARS-CoV-2/drug effects ; SARS-CoV-2/physiology ; Virus Internalization/drug effects
Czasopismo naukowe
Tytuł :
Cannabidiol in conjunction with clobazam: analysis of four randomized controlled trials.
Autorzy :
Gunning B; Stichting Epilepsie Instellingen Nederland, Zwolle, The Netherlands.
Mazurkiewicz-Bełdzińska M; Medical University of Gdańsk, Gdańsk, Poland.
Chin RFM; Royal Hospital for Sick Children, Edinburgh, UK.
Bhathal H; Centro Médico Teknon, Neurocenter Barcelona, Barcelona, Spain.
Nortvedt C; GW Research Ltd, Cambridge, UK.
Dunayevich E; Greenwich Biosciences, Inc, Carlsbad, CA, USA.
Checketts D; GW Research Ltd, Cambridge, UK.
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Źródło :
Acta neurologica Scandinavica [Acta Neurol Scand] 2021 Feb; Vol. 143 (2), pp. 154-163. Date of Electronic Publication: 2020 Oct 22.
Typ publikacji :
Journal Article; Meta-Analysis
MeSH Terms :
Anticonvulsants/*therapeutic use
Cannabidiol/*therapeutic use
Clobazam/*therapeutic use
Epilepsies, Myoclonic/*drug therapy
Lennox Gastaut Syndrome/*drug therapy
Adult ; Anticonvulsants/administration & dosage ; Anticonvulsants/adverse effects ; Cannabidiol/administration & dosage ; Cannabidiol/adverse effects ; Clobazam/administration & dosage ; Clobazam/adverse effects ; Female ; Humans ; Male ; Randomized Controlled Trials as Topic
Czasopismo naukowe
Tytuł :
Polycystic ovarian syndrome in Nigerian women with epilepsy on carbamazepine/levetiracetam monotherapy.
Autorzy :
Ogunjimi L; Department of Pharmacology and Therapeutics, Obafemi Awolowo College of Health Sciences, Olabisi Onabanjo University, Sagamu, Nigeria.
Yaria J; Department of Medicine, University College Hospital, Ibadan, Nigeria.
Makanjuola A; Department of Medicine, University College Hospital, Ibadan, Nigeria.
Alabi A; Department of Pharmacology and Therapeutics, Obafemi Awolowo College of Health Sciences, Olabisi Onabanjo University, Sagamu, Nigeria.
Osalusi B; Department of Medicine, Obafemi Awolowo College of Health Sciences, Olabisi Onabanjo University, Sagamu, Nigeria.
Oboh D; Department of Radiology, University College Hospital, Ibadan, Nigeria.
Olusola-Bello M; Radiology Unit, Department of Surgery, Obafemi Awolowo College of Health Sciences, Olabisi Onabanjo University, Sagamu, Nigeria.
Olawale O; Department of Chemical Pathology and Immunology, Obafemi Awolowo College of Health Sciences, Olabisi Onabanjo University, Sagamu, Nigeria.
Ogunniyi A; Department of Medicine, University College Hospital, Ibadan, Nigeria.
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Źródło :
Acta neurologica Scandinavica [Acta Neurol Scand] 2021 Feb; Vol. 143 (2), pp. 146-153. Date of Electronic Publication: 2020 Oct 22.
Typ publikacji :
Journal Article
MeSH Terms :
Anticonvulsants/*adverse effects
Carbamazepine/*adverse effects
Epilepsy/*drug therapy
Levetiracetam/*adverse effects
Polycystic Ovary Syndrome/*epidemiology
Adult ; Anticonvulsants/administration & dosage ; Anticonvulsants/therapeutic use ; Carbamazepine/administration & dosage ; Carbamazepine/therapeutic use ; Female ; Humans ; Levetiracetam/administration & dosage ; Levetiracetam/therapeutic use ; Nigeria ; Polycystic Ovary Syndrome/etiology
Czasopismo naukowe
Tytuł :
Factors to influence the accuracy of albumin adjusted free valproic acid concentration.
Autorzy :
Tseng YJ; Department of Pharmacy, National Taiwan University Hospital, College of Medicine, National Taiwan University, 7 Chung Shan S. Rd., Taipei, Taiwan. Electronic address: .
Huang SY; Department of Laboratory Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, 7 Chung Shan S. Rd., Taipei, Taiwan. Electronic address: .
Kuo CH; Department of Laboratory Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, 7 Chung Shan S. Rd., Taipei, Taiwan. Electronic address: .
Wang CY; School of Pharmacy, College of Medicine, National Taiwan University, 33 Linsen South Road, Taipei, Taiwan; Graduate Institute of Clinical Pharmacy, College of Medicine, National Taiwan University, 33 Linsen South Road, Taipei, Taiwan; Department of Pharmacy, National Taiwan University Hospital Yun-Lin Branch, College of Medicine, National Taiwan University, No. 579, Sec.2, Yunlin Rd., Douliu City, Yun-Lin County, Taiwan. Electronic address: .
Wang KC; Division of Neurosurgery, Department of Surgery, National Taiwan University Hospital, College of Medicine, National Taiwan University, 7 Chung Shan S. Rd., Taipei, Taiwan. Electronic address: .
Wu CC; Department of Pharmacy, National Taiwan University Hospital, College of Medicine, National Taiwan University, 7 Chung Shan S. Rd., Taipei, Taiwan; School of Pharmacy, College of Medicine, National Taiwan University, 33 Linsen South Road, Taipei, Taiwan. Electronic address: .
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Źródło :
Journal of the Formosan Medical Association = Taiwan yi zhi [J Formos Med Assoc] 2021 Apr; Vol. 120 (4), pp. 1114-1120. Date of Electronic Publication: 2020 Sep 23.
Typ publikacji :
Journal Article
MeSH Terms :
Anticonvulsants*/therapeutic use
Valproic Acid*
Adult ; Albumins ; Drug Monitoring ; Humans ; Reference Values
Czasopismo naukowe
Tytuł :
Potential anti-epileptic phytoconstituents: An updated review.
Autorzy :
Kaur J; School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, 144411, India.
Famta P; Institute of Nano Science and Technology, Phase-10, Sector-64, Mohali, Punjab, 160062, India.
Famta M; Department of Pharmacy, Birla Institute of Technology and Sciences (BITS), Vidya Vihar Campus, Street Number 41, Pilani, Rajasthan, 333031, India.
Mehta M; School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, 144411, India; Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, NSW, 2007, Australia.
Satija S; School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, 144411, India; Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, NSW, 2007, Australia.
Sharma N; School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, 144411, India.
Vyas M; School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, 144411, India.
Khatik GL; School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, 144411, India.
Chellappan DK; Department of Life Sciences, School of Pharmacy, International Medical University (IMU), Bukit Jalil, 57000, Kuala Lumpur, Malaysia.
Dua K; Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, NSW, 2007, Australia; Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute (HMRI) & School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, NSW, 2308, Australia.
Khurana N; School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, 144411, India. Electronic address: .
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Źródło :
Journal of ethnopharmacology [J Ethnopharmacol] 2021 Mar 25; Vol. 268, pp. 113565. Date of Electronic Publication: 2020 Nov 07.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Plants, Medicinal*
Anticonvulsants/*therapeutic use
Epilepsy/*drug therapy
Ethnopharmacology/*methods
Phytochemicals/*therapeutic use
Plant Extracts/*therapeutic use
Animals ; Anticonvulsants/isolation & purification ; Epilepsy/diagnosis ; Epilepsy/metabolism ; Humans ; Medicine, Traditional/methods ; Phytochemicals/isolation & purification ; Plant Extracts/isolation & purification
Czasopismo naukowe
Tytuł :
Changes in Seizure Frequency and Antiepileptic Therapy during Pregnancy. Reply.
Autorzy :
Pennell PB; Brigham and Women's Hospital, Boston, MA .
Meador KJ; Stanford University, Palo Alto, CA.
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Źródło :
The New England journal of medicine [N Engl J Med] 2021 Mar 11; Vol. 384 (10), pp. 977-978.
Typ publikacji :
Letter; Comment
MeSH Terms :
Anticonvulsants*/adverse effects
Epilepsy*/drug therapy
Female ; Humans ; Pregnancy ; Seizures/chemically induced ; Seizures/drug therapy
Opinia redakcyjna
Tytuł :
Cognition and memory impairment attenuation via reduction of oxidative stress in acute and chronic mice models of epilepsy using antiepileptogenic Nux vomica.
Autorzy :
Mishra P; Amity Institute of Neuropsychology and Neurosciences (AINN), Amity University, Noida, Uttar Pradesh, 201303, India.
Mittal AK; Amity Institute of Indian System of Medicine (AIISM), Amity University, Noida, Uttar Pradesh, 201303, India.
Rajput SK; Amity Institute of Indian System of Medicine (AIISM), Amity University, Noida, Uttar Pradesh, 201303, India; Department of Pharmaceutical Sciences, Gurukul Kangri (deemed to be University), Haridwar, Uttrakhand, 249404, India. Electronic address: .
Sinha JK; Amity Institute of Neuropsychology and Neurosciences (AINN), Amity University, Noida, Uttar Pradesh, 201303, India. Electronic address: .
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Źródło :
Journal of ethnopharmacology [J Ethnopharmacol] 2021 Mar 01; Vol. 267, pp. 113509. Date of Electronic Publication: 2020 Oct 23.
Typ publikacji :
Journal Article
MeSH Terms :
Strychnos nux-vomica*/chemistry
Anticonvulsants/*pharmacology
Antioxidants/*pharmacology
Behavior, Animal/*drug effects
Brain/*drug effects
Cognition/*drug effects
Cognitive Dysfunction/*prevention & control
Epilepsy/*prevention & control
Memory/*drug effects
Memory Disorders/*prevention & control
Nootropic Agents/*pharmacology
Oxidative Stress/*drug effects
Plant Extracts/*pharmacology
Acute Disease ; Animals ; Anticonvulsants/isolation & purification ; Antioxidants/isolation & purification ; Brain/metabolism ; Brain/physiopathology ; Chronic Disease ; Cognitive Dysfunction/etiology ; Cognitive Dysfunction/metabolism ; Cognitive Dysfunction/psychology ; Disease Models, Animal ; Epilepsy/chemically induced ; Epilepsy/metabolism ; Epilepsy/physiopathology ; Kindling, Neurologic/drug effects ; Lipid Peroxidation/drug effects ; Male ; Memory Disorders/etiology ; Memory Disorders/metabolism ; Memory Disorders/psychology ; Mice ; Nootropic Agents/isolation & purification ; Pentylenetetrazole ; Plant Extracts/isolation & purification
Czasopismo naukowe
Tytuł :
Should we prescribe anticonvulsants for acute herpes zoster neuralgia and to prevent postherpetic neuralgia?: A protocol for meta-analysis and benefit-risk assessment.
Autorzy :
Lu Y; Guangzhou University of Traditional Chinese Medicine.; Guangzhou University of Traditional Chinese Medicine, Fifth Clinical Medical College.
Liu K; Guangzhou University of Traditional Chinese Medicine, Fifth Clinical Medical College.
Liang Y; Guangzhou University of Traditional Chinese Medicine, Sports and Health Institute.
Zhang X; Guangzhou Hospital of Traditional Chinese Medicine, Neurosurgery Department.
Liu Y; Guangzhou University of Traditional Chinese Medicine, Fifth Clinical Medical College.
Huang F; Guangzhou University of Traditional Chinese Medicine, Fifth Clinical Medical College.
Gao H; Guangzhou University of Traditional Chinese Medicine, Fifth Clinical Medical College.
Zhuang L; Guangzhou University of Traditional Chinese Medicine.; Guangzhou University of Traditional Chinese Medicine First Affiliated Hospital, Acupuncture Department, Guangzhou, Guangdong, China.
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Źródło :
Medicine [Medicine (Baltimore)] 2021 Feb 19; Vol. 100 (7), pp. e24343.
Typ publikacji :
Journal Article
MeSH Terms :
Anticonvulsants/*administration & dosage
Herpes Zoster/*drug therapy
Neuralgia, Postherpetic/*drug therapy
Pain Management/*methods
Anticonvulsants/adverse effects ; Humans ; Meta-Analysis as Topic ; Risk Assessment ; Systematic Reviews as Topic
Czasopismo naukowe
Tytuł :
Novel considerations on drug safety in epilepsy.
Autorzy :
Mifsud de Gray J; Department of Clinical Pharmacology and Therapeutics, Faculty of Medicine and Surgery, University of Malta , Msida, Malta.
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Źródło :
Expert opinion on drug safety [Expert Opin Drug Saf] 2021 Feb; Vol. 20 (2), pp. 119-121. Date of Electronic Publication: 2020 Dec 27.
Typ publikacji :
Editorial
MeSH Terms :
Anticonvulsants/*therapeutic use
Epilepsy/*drug therapy
Animals ; Anticonvulsants/adverse effects ; Humans ; Risk Factors
Opinia redakcyjna
Tytuł :
[Cenobamate-a new perspective for epilepsy treatment].
Autorzy :
Steinhoff BJ; Epilepsiezentrum Kork, Landstraße 1, 77694, Kehl-Kork, Deutschland. .; Klinik für Neurologie, Albert-Ludwigs Universität Freiburg, Freiburg, Deutschland. .
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Transliterated Title :
Cenobamat – eine neue Perspektive für die Epilepsietherapie.
Źródło :
Der Nervenarzt [Nervenarzt] 2021 Feb; Vol. 92 (2), pp. 150-160. Date of Electronic Publication: 2020 Sep 29.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Anticonvulsants*/therapeutic use
Epilepsy*/drug therapy
Carbamates/therapeutic use ; Chlorophenols ; Humans ; Seizures/drug therapy ; Tetrazoles
Czasopismo naukowe
Tytuł :
Effect of drug interactions between carbapenems and valproate on serum valproate concentration: a systematic review and meta-analysis.
Autorzy :
Chai PY; Department of Pharmacy, Chang Gung Memorial Hospital , Keelung, Taiwan.
Chang CT; Department of Pharmacy, Chang Gung Memorial Hospital , Keelung, Taiwan.
Chen YH; Department of Pharmacy, Chang Gung Memorial Hospital , Keelung, Taiwan.
Chen HY; Department of Pharmacy, Chang Gung Memorial Hospital , Linkou, Taiwan.
Tam KW; Center for Evidence-Based Health Care, Department of Medical Research, Shuang Ho Hospital, Taipei Medical University , New Taipei City, Taiwan.; Division of General Surgery, Department of Surgery Shuang Ho Hospital, Taipei Medical University , New Taipei City, Taiwan.; Division of General Surgery, Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University , Taipei, Taiwan.; Cochrane Taiwan, Taipei Medical University , Taipei, Taiwan.
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Źródło :
Expert opinion on drug safety [Expert Opin Drug Saf] 2021 Feb; Vol. 20 (2), pp. 215-223. Date of Electronic Publication: 2020 Dec 28.
Typ publikacji :
Journal Article; Meta-Analysis; Systematic Review
MeSH Terms :
Anticonvulsants/*administration & dosage
Carbapenems/*administration & dosage
Valproic Acid/*administration & dosage
Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/pharmacology ; Anticonvulsants/pharmacokinetics ; Carbapenems/pharmacology ; Dose-Response Relationship, Drug ; Drug Interactions ; Epilepsy/drug therapy ; Humans ; Time Factors ; Valproic Acid/pharmacokinetics
Czasopismo naukowe
Tytuł :
Gabapentin add-on treatment for drug-resistant focal epilepsy.
Autorzy :
Panebianco M; Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.
Al-Bachari S; Department of Neurology, Royal Preston Hospital, Preston, UK.
Hutton JL; Department of Statistics, University of Warwick, Coventry, UK.
Marson AG; Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.; The Walton Centre NHS Foundation Trust, Liverpool, UK.; Liverpool Health Partners, Liverpool, UK.
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Źródło :
The Cochrane database of systematic reviews [Cochrane Database Syst Rev] 2021 Jan 12; Vol. 1. Cochrane AN: CD001415. Date of Electronic Publication: 2021 Jan 12.
Typ publikacji :
Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Systematic Review
MeSH Terms :
Anticonvulsants/*therapeutic use
Cyclohexanecarboxylic Acids/*therapeutic use
Drug Resistant Epilepsy/*drug therapy
Epilepsies, Partial/*drug therapy
Gabapentin/*therapeutic use
gamma-Aminobutyric Acid/*therapeutic use
Adult ; Anticonvulsants/administration & dosage ; Anticonvulsants/adverse effects ; Child ; Drug Therapy, Combination/methods ; Gabapentin/administration & dosage ; Gabapentin/adverse effects ; Humans ; Intention to Treat Analysis ; Patient Dropouts/statistics & numerical data ; Randomized Controlled Trials as Topic
Czasopismo naukowe
Tytuł :
Nose-to-Brain Delivery of Diazepam from an Intranasal Aqua-Triggered In-Situ (ATIS) Gelling Microemulsion: Monitoring Brain Uptake by Microdialysis.
Autorzy :
Bachhav SS; Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, N.P. Marg, Matunga (E), Mumbai, Maharashtra, 400019, India.
Dighe V; National Center for Preclinical Reproductive and Genetic Toxicology, National Institute for Research in Reproductive Health (NIRRH), ICMR, J. M. Street, Parel, Mumbai, 400012, India.
Mali N; Department of Clinical Pharmacology, Seth GS Medical College and KEM Hospital, Mumbai, Maharashtra, India.
Gogtay NJ; Department of Clinical Pharmacology, Seth GS Medical College and KEM Hospital, Mumbai, Maharashtra, India.
Thatte UM; Department of Clinical Pharmacology, Seth GS Medical College and KEM Hospital, Mumbai, Maharashtra, India.
Devarajan PV; Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, N.P. Marg, Matunga (E), Mumbai, Maharashtra, 400019, India. .
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Źródło :
European journal of drug metabolism and pharmacokinetics [Eur J Drug Metab Pharmacokinet] 2020 Dec; Vol. 45 (6), pp. 785-799.
Typ publikacji :
Journal Article
MeSH Terms :
Anticonvulsants/*administration & dosage
Anticonvulsants/*pharmacokinetics
Brain/*metabolism
Diazepam/*administration & dosage
Diazepam/*pharmacokinetics
Adhesiveness ; Administration, Intranasal ; Animals ; Anticonvulsants/adverse effects ; Diazepam/adverse effects ; Drug Compounding ; Drug Delivery Systems ; Emulsions ; Extracellular Fluid/metabolism ; Gels ; Irritants ; Male ; Microdialysis ; Nasal Mucosa ; Rats
Czasopismo naukowe
Tytuł :
Comparisons of Four Protein-Binding Models Characterizing the Pharmacokinetics of Unbound Phenytoin in Adult Patients Using Non-Linear Mixed-Effects Modeling.
Autorzy :
Jun H; College of Pharmacy, Seoul National University, Seoul, Republic of Korea.; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Katz Group Centre for Pharmacy and Health Research, Room 3-142D, 11361-87 Avenue, Edmonton, AB, T6G 2E1, Canada.
Rong Y; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Katz Group Centre for Pharmacy and Health Research, Room 3-142D, 11361-87 Avenue, Edmonton, AB, T6G 2E1, Canada.
Yih C; Department of Pharmacy, Vancouver General Hospital, Vancouver, BC, Canada.
Ho J; Department of Pharmacy, Vancouver General Hospital, Vancouver, BC, Canada.
Cheng W; Department of Pharmacy, Vancouver General Hospital, Vancouver, BC, Canada.
Kiang TKL; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Katz Group Centre for Pharmacy and Health Research, Room 3-142D, 11361-87 Avenue, Edmonton, AB, T6G 2E1, Canada. .
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Źródło :
Drugs in R&D [Drugs R D] 2020 Dec; Vol. 20 (4), pp. 343-358. Date of Electronic Publication: 2020 Oct 07.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Anticonvulsants/*blood
Anticonvulsants/*pharmacokinetics
Phenytoin/*blood
Phenytoin/*pharmacokinetics
Adult ; Aged ; Aged, 80 and over ; Anticonvulsants/administration & dosage ; Drug Monitoring ; Female ; Humans ; Male ; Middle Aged ; Models, Biological ; Nonlinear Dynamics ; Phenytoin/administration & dosage ; Protein Binding ; Retrospective Studies ; Serum Albumin/metabolism ; Young Adult
Czasopismo naukowe
Tytuł :
Design, synthesis, and anticonvulsant effects evaluation of nonimidazole histamine H 3 receptor antagonists/inverse agonists containing triazole moiety.
Autorzy :
Song M; Medical College, Jinggangshan University, Ji'an, China.
Yan R; Medical College, Jinggangshan University, Ji'an, China.
Zhang Y; Medical College, Jinggangshan University, Ji'an, China.
Guo D; Medical College, Jinggangshan University, Ji'an, China.
Zhou N; College of Life Sciences, Zhejiang University, Hangzhou, China.
Deng X; Medical College, Jinggangshan University, Ji'an, China.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2020 Dec; Vol. 35 (1), pp. 1310-1321.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Design*
Anticonvulsants/*chemistry
Histamine H3 Antagonists/*chemistry
Triazoles/*chemistry
Animals ; Anticonvulsants/chemical synthesis ; Anticonvulsants/therapeutic use ; Dose-Response Relationship, Drug ; Drug Inverse Agonism ; Histamine H3 Antagonists/pharmacology ; Mice ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Cenobamate for the treatment of focal epilepsies.
Autorzy :
Strzelczyk A; Epilepsy Center Frankfurt Rhine-Main, Center of Neurology and Neurosurgery, Goethe-University Frankfurt , Frankfurt Am Main, Germany.; LOEWE Center for Personalized Translational Epilepsy Research (Cepter), Goethe-University Frankfurt , Frankfurt Am Main, Germany.
Mann C; Epilepsy Center Frankfurt Rhine-Main, Center of Neurology and Neurosurgery, Goethe-University Frankfurt , Frankfurt Am Main, Germany.; LOEWE Center for Personalized Translational Epilepsy Research (Cepter), Goethe-University Frankfurt , Frankfurt Am Main, Germany.
Willems LM; Epilepsy Center Frankfurt Rhine-Main, Center of Neurology and Neurosurgery, Goethe-University Frankfurt , Frankfurt Am Main, Germany.; LOEWE Center for Personalized Translational Epilepsy Research (Cepter), Goethe-University Frankfurt , Frankfurt Am Main, Germany.
Rosenow F; Epilepsy Center Frankfurt Rhine-Main, Center of Neurology and Neurosurgery, Goethe-University Frankfurt , Frankfurt Am Main, Germany.; LOEWE Center for Personalized Translational Epilepsy Research (Cepter), Goethe-University Frankfurt , Frankfurt Am Main, Germany.
Bauer S; Epilepsy Center Frankfurt Rhine-Main, Center of Neurology and Neurosurgery, Goethe-University Frankfurt , Frankfurt Am Main, Germany.; LOEWE Center for Personalized Translational Epilepsy Research (Cepter), Goethe-University Frankfurt , Frankfurt Am Main, Germany.
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Źródło :
Expert opinion on pharmacotherapy [Expert Opin Pharmacother] 2020 Dec; Vol. 21 (18), pp. 2215-2223. Date of Electronic Publication: 2020 Aug 19.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Anticonvulsants/*therapeutic use
Carbamates/*therapeutic use
Chlorophenols/*therapeutic use
Epilepsies, Partial/*drug therapy
Tetrazoles/*therapeutic use
Animals ; Anticonvulsants/administration & dosage ; Anticonvulsants/adverse effects ; Anticonvulsants/blood ; Carbamates/administration & dosage ; Carbamates/adverse effects ; Carbamates/blood ; Chlorophenols/administration & dosage ; Chlorophenols/adverse effects ; Chlorophenols/blood ; Headache/chemically induced ; Humans ; Randomized Controlled Trials as Topic ; Tetrazoles/administration & dosage ; Tetrazoles/adverse effects ; Tetrazoles/blood ; Treatment Outcome
Czasopismo naukowe
Tytuł :
1,2,4-Triazole-based anticonvulsant agents with additional ROS scavenging activity are effective in a model of pharmacoresistant epilepsy.
Autorzy :
Kaproń B; Department of Clinical Genetics, I Faculty of Medicine with Dentistry Division, Medical University of Lublin, Lublin, Poland.
Czarnomysy R; Department of Synthesis and Technology of Drugs, Faculty of Pharmacy, Medical University of Białystok, Bialystok, Poland.
Wysokiński M; Department of Basic Nursing and Medical Teaching, Chair of Development in Nursing, Faculty of Health Sciences, Medical University of Lublin, Lublin, Poland.
Andrys R; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic.
Musilek K; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic.
Angeli A; Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Firenze, Italy.
Supuran CT; Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Firenze, Italy.
Plech T; Department of Pharmacology, Faculty of Health Sciences, Medical University of Lublin, Lublin, Poland.
Pokaż więcej
Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2020 Dec; Vol. 35 (1), pp. 993-1002.
Typ publikacji :
Journal Article
MeSH Terms :
Anticonvulsants/*pharmacology
Antioxidants/*pharmacology
Carbonic Anhydrase Inhibitors/*pharmacology
Cholinesterase Inhibitors/*pharmacology
Epilepsy/*drug therapy
Triazoles/*pharmacology
Acetylcholinesterase/metabolism ; Animals ; Anticonvulsants/chemical synthesis ; Anticonvulsants/chemistry ; Antioxidants/chemical synthesis ; Antioxidants/chemistry ; Biphenyl Compounds/antagonists & inhibitors ; Butyrylcholinesterase/metabolism ; Carbonic Anhydrase Inhibitors/chemical synthesis ; Carbonic Anhydrase Inhibitors/chemistry ; Carbonic Anhydrases/metabolism ; Cell Line, Tumor ; Cell Survival/drug effects ; Cholinesterase Inhibitors/chemical synthesis ; Cholinesterase Inhibitors/chemistry ; Dose-Response Relationship, Drug ; Epilepsy/metabolism ; Humans ; Mice ; Models, Molecular ; Molecular Structure ; Oxidative Stress/drug effects ; Picrates/antagonists & inhibitors ; Reactive Oxygen Species/metabolism ; Structure-Activity Relationship ; Triazoles/chemical synthesis ; Triazoles/chemistry
Czasopismo naukowe

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