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Wyświetlanie 41-60 z 30843
Tytuł:
Spatial and temporal correlations in human cortex are inherently linked and predicted by functional hierarchy, vigilance state as well as antiepileptic drug load.
Autorzy:
Müller PM; Computational Neurology Lab, Department of Neurology, Charité-Universitätsmedizin Berlin, Berlin, Germany.; Berlin Institute of Health, Berlin, Germany.; NeuroCure Cluster of Excellence, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Meisel C; Computational Neurology Lab, Department of Neurology, Charité-Universitätsmedizin Berlin, Berlin, Germany.; Berlin Institute of Health, Berlin, Germany.; NeuroCure Cluster of Excellence, Charité-Universitätsmedizin Berlin, Berlin, Germany.; Center for Stroke Research Berlin, Berlin, Germany.; Bernstein Center for Computational Neuroscience, Berlin, Germany.
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Źródło:
PLoS computational biology [PLoS Comput Biol] 2023 Mar 03; Vol. 19 (3), pp. e1010919. Date of Electronic Publication: 2023 Mar 03 (Print Publication: 2023).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Anticonvulsants*/pharmacology
Wakefulness*
Humans ; Brain/physiology ; Brain Mapping/methods ; Magnetic Resonance Imaging/methods
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Engineering of an ene-reductase for producing the key intermediate of antiepileptic drug Brivaracetam.
Autorzy:
Sun L; Department of Chemistry, Shanghai University, Shangda Road 99, Shanghai, China.
Liu Y; Synthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education and College of Chemistry and Molecular Engineering, Peking University, Beijing, China.
Song H; State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Ling Ling Road 345, Shanghai, China.
Hao J; Department of Chemistry, Shanghai University, Shangda Road 99, Shanghai, China.
Lin L; Synthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education and College of Chemistry and Molecular Engineering, Peking University, Beijing, China. .
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Źródło:
Applied microbiology and biotechnology [Appl Microbiol Biotechnol] 2023 Mar; Vol. 107 (5-6), pp. 1649-1661. Date of Electronic Publication: 2023 Jan 30.
Typ publikacji:
Journal Article
MeSH Terms:
Oxidoreductases*/genetics
Anticonvulsants*
Pyrrolidinones ; Mutagenesis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Interaction of Varenicline with Classic Antiseizure Medications in the Mouse Maximal Electroshock-Induced Seizure Model.
Autorzy:
Bernat P; Department of Experimental and Clinical Pharmacology, University of Rzeszów, 35-310 Rzeszów, Poland.
Kołodziejczyk P; Department of Experimental and Clinical Pharmacology, University of Rzeszów, 35-310 Rzeszów, Poland.
Łuszczki JJ; Department of Occupational Medicine, Medical University of Lublin, 20-059 Lublin, Poland.
Zagaja M; Isobolographic Analysis Laboratory, Institute of Rural Health, 20-090 Lublin, Poland.
Tutka P; Department of Experimental and Clinical Pharmacology, University of Rzeszów, 35-310 Rzeszów, Poland.; Laboratory for Innovative Research in Pharmacology, University of Rzeszów, 35-310 Rzeszów, Poland.; National Drug and Alcohol Research Centre, University of New South Wales, Sydney, NSW 2052, Australia.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jan 30; Vol. 24 (3). Date of Electronic Publication: 2023 Jan 30.
Typ publikacji:
Journal Article
MeSH Terms:
Anticonvulsants*/pharmacology
Anticonvulsants*/therapeutic use
Seizures*/drug therapy
Seizures*/etiology
Humans ; Mice ; Animals ; Varenicline/pharmacology ; Varenicline/therapeutic use ; Electroshock/adverse effects ; Brain ; Carbamazepine/pharmacology ; Phenobarbital/pharmacology ; Phenobarbital/therapeutic use ; Valproic Acid/pharmacology ; Phenytoin ; Dose-Response Relationship, Drug ; Disease Models, Animal
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Antiseizure Effects of Scoparone, Borneol and Their Impact on the Anticonvulsant Potency of Four Classic Antiseizure Medications in the Mouse MES Model-An Isobolographic Transformation.
Autorzy:
Łuszczki JJ; Department of Occupational Medicine, Medical University of Lublin, 20-090 Lublin, Poland.
Bojar H; Department of Toxicology and Food Safety, Institute of Rural Health, 20-090 Lublin, Poland.
Góralczyk A; Department of Occupational Medicine, Medical University of Lublin, 20-090 Lublin, Poland.
Skalicka-Woźniak K; Department of Natural Products Chemistry, Medical University of Lublin, 20-093 Lublin, Poland.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jan 11; Vol. 24 (2). Date of Electronic Publication: 2023 Jan 11.
Typ publikacji:
Journal Article
MeSH Terms:
Anticonvulsants*/therapeutic use
Anticonvulsants*/pharmacokinetics
Valproic Acid*/pharmacology
Valproic Acid*/therapeutic use
Animals ; Mice ; Electroshock ; Drug Interactions ; Coumarins/pharmacology ; Coumarins/therapeutic use ; Seizures/drug therapy ; Seizures/etiology ; Phenobarbital/pharmacology ; Phenobarbital/therapeutic use ; Brain ; Disease Models, Animal ; Dose-Response Relationship, Drug
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Association of Human Leukocyte Antigen Alleles with Carbamazepine- or Lamotrigine-Induced Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in an Iranian Population: A Case-control Study.
Autorzy:
Dastgheib L; Molecular Dermatology Research Center, Department of Dermatology, Shiraz University of Medical Sciences, Shiraz, Iran.
Rostami F; Student Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Gharesi-Fard B; Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Asadi-Pooya AA; Epilepsy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.; Jefferson Comprehensive Epilepsy Center, Department of Neurology, Thomas Jefferson University, Philadelphia, PA, USA.
Namjoo S; Blood Transfusion Research Center, High Institute for Education and Research in Transfusion Medicine, Tehran, Iran.
Tahmasebi F; Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Hadibarhaghtalab M; Molecular Dermatology Research Center, Department of Dermatology, Shiraz University of Medical Sciences, Shiraz, Iran.
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Źródło:
Iranian journal of medical sciences [Iran J Med Sci] 2023 Jan; Vol. 48 (1), pp. 70-76.
Typ publikacji:
Journal Article
MeSH Terms:
Anticonvulsants*/adverse effects
Stevens-Johnson Syndrome*/genetics
Humans ; Lamotrigine/adverse effects ; Iran ; Alleles ; Case-Control Studies ; HLA-B Antigens/genetics ; Asian People ; Carbamazepine/adverse effects ; Benzodiazepines
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Ranolazine Interacts Antagonistically with Some Classical Antiepileptic Drugs-An Isobolographic Analysis.
Autorzy:
Borowicz-Reutt K; Independent Unit of Experimental Neuropathophysiology, Department of Toxicology, Medical University of Lublin, Jaczewskiego 8b, PL-20-090 Lublin, Poland.
Banach M; Independent Unit of Experimental Neuropathophysiology, Department of Toxicology, Medical University of Lublin, Jaczewskiego 8b, PL-20-090 Lublin, Poland.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2022 Dec 15; Vol. 27 (24). Date of Electronic Publication: 2022 Dec 15.
Typ publikacji:
Journal Article
MeSH Terms:
Anticonvulsants*/pharmacology
Anticonvulsants*/therapeutic use
Epilepsy*/drug therapy
Animals ; Mice ; Ranolazine/pharmacology ; Ranolazine/therapeutic use ; Phenytoin/pharmacology ; Drug Interactions ; Seizures/drug therapy ; Seizures/etiology ; Carbamazepine/pharmacology ; Phenobarbital/pharmacology ; Brain ; Electroshock/adverse effects ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Avoidance Learning
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Changes in the Dentate Gyrus Gene Expression Profile Induced by Levetiracetam Treatment in Rats with Mesial Temporal Lobe Epilepsy.
Autorzy:
Diaz-Villegas V; Departamento de Fisiología, Instituto Politécnico Nacional, Escuela Nacional de Ciencias Biológicas, Mexico City 07738, Mexico.; Laboratorio de Neurociencias, Subdirección de Medicina Experimental, Instituto Nacional de Pediatría, Mexico City 04530, Mexico.
Pichardo-Macías LA; Departamento de Fisiología, Instituto Politécnico Nacional, Escuela Nacional de Ciencias Biológicas, Mexico City 07738, Mexico.
Juárez-Méndez S; Laboratorio de Oncología Experimental, Instituto Nacional de Pediatría, Secretaría de Salud, Mexico City 04530, Mexico.
Ignacio-Mejía I; Laboratorio de Medicina Traslacional, Escuela Militar de Graduados de Sanidad, Universidad del Ejército y Fuerza Aérea, Mexico City 11200, Mexico.
Cárdenas-Rodríguez N; Laboratorio de Neurociencias, Subdirección de Medicina Experimental, Instituto Nacional de Pediatría, Mexico City 04530, Mexico.
Vargas-Hernández MA; Subdirección de Investigación, Escuela Militar de Graduados de Sanidad, Universidad del Ejército y Fuerza Aérea, Mexico City 11200, Mexico.
Mendoza-Torreblanca JG; Laboratorio de Neurociencias, Subdirección de Medicina Experimental, Instituto Nacional de Pediatría, Mexico City 04530, Mexico.
Zamudio SR; Departamento de Fisiología, Instituto Politécnico Nacional, Escuela Nacional de Ciencias Biológicas, Mexico City 07738, Mexico.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Jan 30; Vol. 25 (3). Date of Electronic Publication: 2024 Jan 30.
Typ publikacji:
Journal Article
MeSH Terms:
Epilepsy, Temporal Lobe*/chemically induced
Epilepsy, Temporal Lobe*/drug therapy
Epilepsy, Temporal Lobe*/genetics
Piracetam*/pharmacology
Piracetam*/therapeutic use
Epilepsy*/drug therapy
Humans ; Rats ; Animals ; Levetiracetam/pharmacology ; Levetiracetam/therapeutic use ; Transcriptome ; Anticonvulsants/pharmacology ; Anticonvulsants/therapeutic use ; Dentate Gyrus
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
High Doses of ANA12 Improve Phenobarbital Efficacy in a Model of Neonatal Post-Ischemic Seizures.
Autorzy:
Vyas P; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Chaturvedi I; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Hwang Y; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Scafidi J; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Department of Neurology and Developmental Medicine, Kennedy Krieger Institute, Baltimore, MD 21205, USA.
Kadam SD; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Department of Neurology and Developmental Medicine, Kennedy Krieger Institute, Baltimore, MD 21205, USA.; Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Stafstrom CE; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Jan 24; Vol. 25 (3). Date of Electronic Publication: 2024 Jan 24.
Typ publikacji:
Journal Article
MeSH Terms:
Epilepsy*/drug therapy
Hypoxia-Ischemia, Brain*/drug therapy
Animals ; Mice ; Anticonvulsants/pharmacology ; Anticonvulsants/therapeutic use ; Animals, Newborn ; Disease Models, Animal ; Seizures/drug therapy ; Seizures/etiology ; Seizures/metabolism ; Phenobarbital/pharmacology ; Phenobarbital/therapeutic use ; Ischemia/drug therapy
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Polymorphisms Affecting the Response to Novel Antiepileptic Drugs.
Autorzy:
Urzì Brancati V; Department of Clinical and Experimental Medicine, University of Messina, Via C. Valeria, 98125 Messina, Italy.
Pinto Vraca T; Department of Clinical and Experimental Medicine, University of Messina, Via C. Valeria, 98125 Messina, Italy.
Minutoli L; Department of Clinical and Experimental Medicine, University of Messina, Via C. Valeria, 98125 Messina, Italy.
Pallio G; Department of Clinical and Experimental Medicine, University of Messina, Via C. Valeria, 98125 Messina, Italy.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jan 28; Vol. 24 (3). Date of Electronic Publication: 2023 Jan 28.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Anticonvulsants*/pharmacology
Epilepsy*/drug therapy
Epilepsy*/genetics
Epilepsy*/epidemiology
Humans ; Pharmacogenetics ; Polymorphism, Single Nucleotide ; Drug Resistance/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Effect of date molasses on levetiracetam pharmacokinetics in healthy rats.
Autorzy:
Abu Dayyih W; Faculty of Pharmacy, Mutah University, Al-Karak, Jordan. .
Layth R; Faculty of Pharmacy and Medical Sciences, University of Petra, Amman, Jordan.
Hailat M; Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman, Jordan.
Alkhawaja B; Faculty of Pharmacy and Medical Sciences, University of Petra, Amman, Jordan.
Al Tamimi L; Faculty of Pharmacy, Zarqa University, Zarqa, Jordan.
Zakaraya Z; Faculty of Pharmacy, Al-Ahliyya Amman University, Amman, Jordan.
Aburumman A; Pharmacological and Diagnostic Research Centre, Faculty of Pharmacy, Al-Ahliyya Amman University, Amman, Jordan.
Al Dmour N; Faculty of Agriculture, Mutah University, Al-Karak, Jordan.
Saadh MJ; Faculty of Pharmacy, Middle East University, Amman, 11831, Jordan.
Al-Matubsi H; Faculty of Pharmacy and Medical Sciences, University of Petra, Amman, Jordan.
Aldalaen SM; Department of Pharmacology, Faculty of Medicine, Mutah University, Al-Karak, Jordan.
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Źródło:
Scientific reports [Sci Rep] 2023 Jan 14; Vol. 13 (1), pp. 758. Date of Electronic Publication: 2023 Jan 14.
Typ publikacji:
Journal Article
MeSH Terms:
Anticonvulsants*
Piracetam*
Rats ; Male ; Animals ; Levetiracetam ; Molasses ; Rats, Wistar
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Influence of Long-Term Anti-Seizure Medications on Redox Parameters in Human Blood.
Autorzy:
Jakovljević, Danijel (AUTHOR)
Nikolić, Milan (AUTHOR)
Jovanović, Vesna (AUTHOR)
Vidonja Uzelac, Teodora (AUTHOR)
Nikolić-Kokić, Aleksandra (AUTHOR)
Novaković, Emilija (AUTHOR)
Miljević, Čedo (AUTHOR)
Milovanović, Maja (AUTHOR)
Blagojević, Duško (AUTHOR)
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Źródło:
Pharmaceuticals (14248247). Jan2024, Vol. 17 Issue 1, p130. 12p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Inhibition of ANXA2 activity attenuates epileptic susceptibility and GluA1 phosphorylation.
Autorzy:
Ma, Limin (AUTHOR)
Wu, Qingyuan (AUTHOR)
Yuan, Jinxian (AUTHOR)
Wang, You (AUTHOR)
Zhang, Peng (AUTHOR)
Liu, Qiankun (AUTHOR)
Tan, Dandan (AUTHOR)
Liang, Minxue (AUTHOR)
Chen, Yangmei (AUTHOR)
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Źródło:
CNS Neuroscience & Therapeutics. Nov2023, Vol. 29 Issue 11, p3644-3656. 13p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Anticonvulsant Activity of Bombyx batryticatus and Analysis of Bioactive Extracts Based on UHPLC-Q-TOF MS/MS and Molecular Networking.
Autorzy:
Wang Q; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Wang R; NMPA Key Laboratory of Quality Evaluation of Traditional Chinese Medicine (Traditional Chinese Patent Medicine), Zhejiang Institute for Food and Drug Control, Hangzhou 310052, China.
Zheng C; NMPA Key Laboratory of Quality Evaluation of Traditional Chinese Medicine (Traditional Chinese Patent Medicine), Zhejiang Institute for Food and Drug Control, Hangzhou 310052, China.
Zhang L; NMPA Key Laboratory of Quality Evaluation of Traditional Chinese Medicine (Traditional Chinese Patent Medicine), Zhejiang Institute for Food and Drug Control, Hangzhou 310052, China.
Meng H; Department of Pharmacological Toxicology, Zhejiang Institute for Food and Drug Control, Hangzhou 310052, China.
Zhang Y; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Ma L; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.; NMPA Key Laboratory of Quality Evaluation of Traditional Chinese Medicine (Traditional Chinese Patent Medicine), Zhejiang Institute for Food and Drug Control, Hangzhou 310052, China.
Chen B; NMPA Key Laboratory of Quality Evaluation of Traditional Chinese Medicine (Traditional Chinese Patent Medicine), Zhejiang Institute for Food and Drug Control, Hangzhou 310052, China.
Wang J; NMPA Key Laboratory of Quality Evaluation of Traditional Chinese Medicine (Traditional Chinese Patent Medicine), Zhejiang Institute for Food and Drug Control, Hangzhou 310052, China.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2022 Nov 29; Vol. 27 (23). Date of Electronic Publication: 2022 Nov 29.
Typ publikacji:
Journal Article
MeSH Terms:
Anticonvulsants*/pharmacology
Bombyx*/chemistry
Mice ; Animals ; Tandem Mass Spectrometry ; Pentylenetetrazole ; Chromatography, High Pressure Liquid/methods ; Seizures/chemically induced ; Seizures/drug therapy ; Plant Extracts/pharmacology ; Plant Extracts/chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
GABRG2 C588T Polymorphism Is Associated with Idiopathic Generalized Epilepsy but Not with Antiepileptic Drug Resistance in Pakistani Cohort.
Autorzy:
Saleem T; Cell and Molecular Biology Laboratory, Institute of Zoology, University of the Punjab, Lahore, Pakistan.
Maqbool H; Cell and Molecular Biology Laboratory, Institute of Zoology, University of the Punjab, Lahore, Pakistan.
Sheikh N; Cell and Molecular Biology Laboratory, Institute of Zoology, University of the Punjab, Lahore, Pakistan.
Tayyeb A; School of Biological Sciences, University of the Punjab, Lahore, Pakistan.
Mukhtar M; Cell and Molecular Biology Laboratory, Institute of Zoology, University of the Punjab, Lahore, Pakistan.
Ashfaq A; Cell and Molecular Biology Laboratory, Institute of Zoology, University of the Punjab, Lahore, Pakistan.
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Źródło:
BioMed research international [Biomed Res Int] 2022 Nov 15; Vol. 2022, pp. 3460792. Date of Electronic Publication: 2022 Nov 15 (Print Publication: 2022).
Typ publikacji:
Journal Article
MeSH Terms:
Anticonvulsants*/therapeutic use
Epilepsy*/drug therapy
Epilepsy*/genetics
Humans ; Pakistan ; Receptors, GABA-A/genetics ; Immunoglobulin E
SCR Disease Name:
Epilepsy, Idiopathic Generalized
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 41-60 z 30843

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