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Wyszukujesz frazę ""Antidotes"" wg kryterium: Temat


Tytuł :
3-Quinuclidinyl-α-methoxydiphenylacetate: A multi-targeted ligand with antimuscarinic and antinicotinic effects designed for the treatment of anticholinesterase poisoning.
Autorzy :
Timperley CM; Chemical, Biological and Radiological (CBR) Division, Defence Science and Technology Laboratory (Dstl), Porton Down, Salisbury, Wiltshire SP4 0JQ, UK. Electronic address: .
Bird M; Chemical, Biological and Radiological (CBR) Division, Defence Science and Technology Laboratory (Dstl), Porton Down, Salisbury, Wiltshire SP4 0JQ, UK.
Gore SJ; Chemical, Biological and Radiological (CBR) Division, Defence Science and Technology Laboratory (Dstl), Porton Down, Salisbury, Wiltshire SP4 0JQ, UK.
Lindsay CD; Chemical, Biological and Radiological (CBR) Division, Defence Science and Technology Laboratory (Dstl), Porton Down, Salisbury, Wiltshire SP4 0JQ, UK.
Rice H; Chemical, Biological and Radiological (CBR) Division, Defence Science and Technology Laboratory (Dstl), Porton Down, Salisbury, Wiltshire SP4 0JQ, UK.
Tattersall JEH; Chemical, Biological and Radiological (CBR) Division, Defence Science and Technology Laboratory (Dstl), Porton Down, Salisbury, Wiltshire SP4 0JQ, UK.
Whitmore CL; Chemical, Biological and Radiological (CBR) Division, Defence Science and Technology Laboratory (Dstl), Porton Down, Salisbury, Wiltshire SP4 0JQ, UK.
Green AC; Chemical, Biological and Radiological (CBR) Division, Defence Science and Technology Laboratory (Dstl), Porton Down, Salisbury, Wiltshire SP4 0JQ, UK.
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Źródło :
Toxicology letters [Toxicol Lett] 2020 Jun 01; Vol. 325, pp. 67-76. Date of Electronic Publication: 2020 Feb 01.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7709027 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3169 (Electronic) Linking ISSN: 03784274 NLM ISO Abbreviation: Toxicol. Lett. Subsets: MEDLINE
MeSH Terms :
Antidotes/*pharmacology
Antidotes/*therapeutic use
Cholinesterase Inhibitors/*poisoning
Muscarinic Antagonists/*pharmacology
Muscarinic Antagonists/*therapeutic use
Nerve Agents/*poisoning
Nicotinic Antagonists/*pharmacology
Nicotinic Antagonists/*therapeutic use
Animals ; Anticonvulsants/chemistry ; Anticonvulsants/therapeutic use ; Antidotes/chemical synthesis ; CHO Cells ; Cell Line ; Cricetinae ; Cricetulus ; Diaphragm/drug effects ; Guinea Pigs ; Humans ; In Vitro Techniques ; Male ; Muscarinic Antagonists/chemical synthesis ; Muscle, Skeletal/drug effects ; Neurons/drug effects ; Nicotinic Antagonists/chemical synthesis ; Seizures/chemically induced ; Seizures/prevention & control ; Soman/poisoning
Czasopismo naukowe
Tytuł :
Differences in biological activities between recombinant human paraoxonase 1 (rhPON1) subtype isozemys R/Q as antidotes against organophosphorus poisonings.
Autorzy :
Cui Y; Department of Emergency Medicine, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Shenyang, 110004, China. Electronic address: .
Zhao M; Department of Emergency Medicine, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Shenyang, 110004, China. Electronic address: .
Han L; Specialist Clinics, Shengjing Hospital of China Medical University, No. 39 Huaxiang Road, Shenyang, 110022, China. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2020 Jun 01; Vol. 325, pp. 51-61. Date of Electronic Publication: 2020 Jan 22.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7709027 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3169 (Electronic) Linking ISSN: 03784274 NLM ISO Abbreviation: Toxicol. Lett. Subsets: MEDLINE
MeSH Terms :
Antidotes/*pharmacology
Aryldialkylphosphatase/*pharmacology
Organophosphate Poisoning/*drug therapy
Acetylcholinesterase/metabolism ; Animals ; Antidotes/chemistry ; Aryldialkylphosphatase/chemistry ; Brain/pathology ; Chlorpyrifos ; Cholinesterase Inhibitors/pharmacology ; Diazinon ; Humans ; Isoenzymes/chemistry ; Isoenzymes/pharmacology ; Lethal Dose 50 ; Male ; Organophosphate Poisoning/pathology ; Organothiophosphorus Compounds/poisoning ; Rats ; Rats, Wistar ; Recombinant Proteins/chemistry ; Recombinant Proteins/pharmacology
Czasopismo naukowe
Tytuł :
Management of epistaxis in patients on novel oral anticoagulation therapy.
Autorzy :
Ho JPK; Department of Otolaryngology Head and Neck Surgery, Westmead Hospital, Australia.; Sydney Medical School, University of Sydney, Camperdown, Australia.
Bari N; Department of Emergency Medicine, Blacktown Hospital, Australia.
Riffat F; Department of Otolaryngology Head and Neck Surgery, Westmead Hospital, Australia.; Sydney Medical School, University of Sydney, Camperdown, Australia.
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Źródło :
The Journal of laryngology and otology [J Laryngol Otol] 2020 Apr; Vol. 134 (4), pp. 316-322. Date of Electronic Publication: 2020 Apr 13.
Typ publikacji :
Comparative Study; Journal Article
Journal Info :
Publisher: Cambridge University Press Country of Publication: England NLM ID: 8706896 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1748-5460 (Electronic) Linking ISSN: 00222151 NLM ISO Abbreviation: J Laryngol Otol Subsets: Core Clinical (AIM); MEDLINE
MeSH Terms :
Antibodies, Monoclonal, Humanized/*therapeutic use
Antidotes/*therapeutic use
Epistaxis/*drug therapy
Administration, Oral ; Aged ; Antibodies, Monoclonal, Humanized/administration & dosage ; Anticoagulants/adverse effects ; Anticoagulants/therapeutic use ; Antidotes/administration & dosage ; Antithrombins/adverse effects ; Antithrombins/therapeutic use ; Arginine/administration & dosage ; Arginine/analogs & derivatives ; Arginine/therapeutic use ; Awareness ; Dabigatran/adverse effects ; Dabigatran/therapeutic use ; Epistaxis/chemically induced ; Epistaxis/epidemiology ; Factor Xa/administration & dosage ; Factor Xa/therapeutic use ; Factor Xa Inhibitors/adverse effects ; Factor Xa Inhibitors/therapeutic use ; First Aid/standards ; Humans ; Male ; Piperazines/administration & dosage ; Piperazines/therapeutic use ; Prevalence ; Recombinant Proteins/administration & dosage ; Recombinant Proteins/therapeutic use ; Rivaroxaban/adverse effects ; Rivaroxaban/therapeutic use ; Severity of Illness Index
Czasopismo naukowe
Tytuł :
Assessment of false transmitters as treatments for nerve agent poisoning.
Autorzy :
Whitmore C; Chemical, Biological and Radiological Division, Defence Science and Technology Laboratory (Dstl), Porton Down, Salisbury, Wiltshire, SP4 0JQ, UK. Electronic address: .
Lindsay CD; Chemical, Biological and Radiological Division, Defence Science and Technology Laboratory (Dstl), Porton Down, Salisbury, Wiltshire, SP4 0JQ, UK.
Bird M; Chemical, Biological and Radiological Division, Defence Science and Technology Laboratory (Dstl), Porton Down, Salisbury, Wiltshire, SP4 0JQ, UK.
Gore SJ; Chemical, Biological and Radiological Division, Defence Science and Technology Laboratory (Dstl), Porton Down, Salisbury, Wiltshire, SP4 0JQ, UK.
Rice H; Chemical, Biological and Radiological Division, Defence Science and Technology Laboratory (Dstl), Porton Down, Salisbury, Wiltshire, SP4 0JQ, UK.
Williams RL; Chemical, Biological and Radiological Division, Defence Science and Technology Laboratory (Dstl), Porton Down, Salisbury, Wiltshire, SP4 0JQ, UK.
Timperley CM; Chemical, Biological and Radiological Division, Defence Science and Technology Laboratory (Dstl), Porton Down, Salisbury, Wiltshire, SP4 0JQ, UK.
Green AC; Chemical, Biological and Radiological Division, Defence Science and Technology Laboratory (Dstl), Porton Down, Salisbury, Wiltshire, SP4 0JQ, UK.
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Źródło :
Toxicology letters [Toxicol Lett] 2020 Mar 15; Vol. 321, pp. 21-31. Date of Electronic Publication: 2019 Dec 09.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7709027 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3169 (Electronic) Linking ISSN: 03784274 NLM ISO Abbreviation: Toxicol. Lett. Subsets: MEDLINE
MeSH Terms :
Acetylcholine/*analogs & derivatives
Antidotes/*pharmacology
Choline/*analogs & derivatives
Cholinesterase Inhibitors/*poisoning
Diaphragm/*innervation
Nerve Agents/*poisoning
Neurotransmitter Agents/*pharmacology
Organophosphate Poisoning/*drug therapy
Soman/*poisoning
Synapses/*drug effects
Acetylcholine/chemical synthesis ; Acetylcholine/metabolism ; Acetylcholine/pharmacology ; Acetylcholinesterase/metabolism ; Animals ; Antidotes/chemical synthesis ; CHO Cells ; Cell Line, Tumor ; Choline/chemical synthesis ; Choline/pharmacology ; Cricetulus ; Drug Partial Agonism ; Guinea Pigs ; Humans ; Male ; Neurotransmitter Agents/chemical synthesis ; Organophosphate Poisoning/enzymology ; Organophosphate Poisoning/physiopathology ; Receptors, Cholinergic/drug effects ; Receptors, Cholinergic/genetics ; Receptors, Cholinergic/metabolism ; Synapses/enzymology
Czasopismo naukowe
Tytuł :
A catalytic bioscavenger with improved stability and reduced susceptibility to oxidation for treatment of acute poisoning with neurotoxic organophosphorus compounds.
Autorzy :
Job L; Lehrstuhl für Biologische Chemie, Technische Universität München, Emil-Erlenmeyer-Forum 5, 85354 Freising, Germany. Electronic address: .
Köhler A; Lehrstuhl für Biologische Chemie, Technische Universität München, Emil-Erlenmeyer-Forum 5, 85354 Freising, Germany; Bundeswehr Institut für Pharmakologie und Toxikologie, Neuherbergstr. 11, 80937 München, Germany. Electronic address: .
Escher B; Lehrstuhl für Biologische Chemie, Technische Universität München, Emil-Erlenmeyer-Forum 5, 85354 Freising, Germany. Electronic address: .
Worek F; Bundeswehr Institut für Pharmakologie und Toxikologie, Neuherbergstr. 11, 80937 München, Germany. Electronic address: .
Skerra A; Lehrstuhl für Biologische Chemie, Technische Universität München, Emil-Erlenmeyer-Forum 5, 85354 Freising, Germany. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2020 Mar 15; Vol. 321, pp. 138-145. Date of Electronic Publication: 2019 Dec 28.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7709027 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3169 (Electronic) Linking ISSN: 03784274 NLM ISO Abbreviation: Toxicol. Lett. Subsets: MEDLINE
MeSH Terms :
Antidotes/*pharmacology
Bacterial Proteins/*pharmacology
Caulobacteraceae/*enzymology
Nerve Agents/*poisoning
Organophosphate Poisoning/*drug therapy
Organophosphorus Compounds/*toxicity
Phosphoric Triester Hydrolases/*pharmacology
Antidotes/metabolism ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Caulobacteraceae/genetics ; Drug Stability ; Enzyme Stability ; Hot Temperature ; Mutation ; Organophosphate Poisoning/enzymology ; Organothiophosphorus Compounds/poisoning ; Oxidation-Reduction ; Phosphoric Triester Hydrolases/genetics ; Phosphoric Triester Hydrolases/metabolism ; Protein Denaturation ; Recombinant Proteins/pharmacology ; Sarin/poisoning ; Soman/poisoning
SCR Organism :
Brevundimonas diminuta
Czasopismo naukowe
Tytuł :
Tuning the allosteric sequestration of anticancer drugs for developing cooperative nano-antidotes.
Autorzy :
Wang W; Department of Chemistry & Biochemistry, The Ohio State University, 100 West 18th Avenue, 43210 Columbus, Ohio, USA. .
Finnegan TJ; Department of Chemistry & Biochemistry, The Ohio State University, 100 West 18th Avenue, 43210 Columbus, Ohio, USA. .
Lei Z; Department of Chemistry & Biochemistry, The Ohio State University, 100 West 18th Avenue, 43210 Columbus, Ohio, USA. .
Zhu X; Department of Chemistry & Biochemistry, The Ohio State University, 100 West 18th Avenue, 43210 Columbus, Ohio, USA. .
Moore CE; Department of Chemistry & Biochemistry, The Ohio State University, 100 West 18th Avenue, 43210 Columbus, Ohio, USA. .
Shi K; Department of Chemistry & Biochemistry, The Ohio State University, 100 West 18th Avenue, 43210 Columbus, Ohio, USA. .
Badjić JD; Department of Chemistry & Biochemistry, The Ohio State University, 100 West 18th Avenue, 43210 Columbus, Ohio, USA. .
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Źródło :
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2020 Jan 25; Vol. 56 (8), pp. 1271-1274. Date of Electronic Publication: 2020 Jan 06.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 9610838 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1364-548X (Electronic) Linking ISSN: 13597345 NLM ISO Abbreviation: Chem. Commun. (Camb.) Subsets: MEDLINE
MeSH Terms :
Anthracyclines/*pharmacology
Antidotes/*pharmacology
Antineoplastic Agents/*pharmacology
Nanostructures/*chemistry
Allosteric Regulation/drug effects ; Anthracyclines/chemical synthesis ; Anthracyclines/chemistry ; Antidotes/chemical synthesis ; Antidotes/chemistry ; Antineoplastic Agents/chemistry ; Hydrogen Bonding ; Hydrophobic and Hydrophilic Interactions ; Models, Molecular ; Molecular Structure
Czasopismo naukowe
Tytuł :
Computational framework for predictive PBPK-PD-Tox simulations of opioids and antidotes.
Autorzy :
German C; CFD Research Corp., Huntsville, AL, 35806, USA. .
Pilvankar M; School of Chemical Engineering, Oklahoma State University, Stillwater, OK, 74078, USA.
Przekwas A; CFD Research Corp., Huntsville, AL, 35806, USA.
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Źródło :
Journal of pharmacokinetics and pharmacodynamics [J Pharmacokinet Pharmacodyn] 2019 Dec; Vol. 46 (6), pp. 513-529. Date of Electronic Publication: 2019 Aug 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Springer Country of Publication: United States NLM ID: 101096520 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-8744 (Electronic) Linking ISSN: 1567567X NLM ISO Abbreviation: J Pharmacokinet Pharmacodyn Subsets: MEDLINE
MeSH Terms :
Analgesics, Opioid/*adverse effects
Analgesics, Opioid/*pharmacokinetics
Antidotes/*adverse effects
Antidotes/*pharmacokinetics
Analgesics, Opioid/administration & dosage ; Antidotes/administration & dosage ; Humans ; Male ; Morphine/adverse effects ; Morphine/pharmacokinetics ; Naloxone/administration & dosage ; Naloxone/adverse effects ; Naloxone/pharmacokinetics ; Narcotic Antagonists/administration & dosage ; Narcotic Antagonists/adverse effects ; Narcotic Antagonists/pharmacokinetics ; Opioid-Related Disorders/drug therapy ; Pain/drug therapy ; Receptors, Opioid/metabolism
Czasopismo naukowe
Tytuł :
A toxin-antidote CRISPR gene drive system for regional population modification.
Autorzy :
Champer J; Department of Computational Biology, Cornell University, Ithaca, NY, 14853, USA. .; Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY, 14853, USA. .
Lee E; Department of Computational Biology, Cornell University, Ithaca, NY, 14853, USA.; Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY, 14853, USA.
Yang E; Department of Computational Biology, Cornell University, Ithaca, NY, 14853, USA.; Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY, 14853, USA.
Liu C; Department of Computational Biology, Cornell University, Ithaca, NY, 14853, USA.; Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY, 14853, USA.
Clark AG; Department of Computational Biology, Cornell University, Ithaca, NY, 14853, USA.; Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY, 14853, USA.
Messer PW; Department of Computational Biology, Cornell University, Ithaca, NY, 14853, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Feb 27; Vol. 11 (1), pp. 1082. Date of Electronic Publication: 2020 Feb 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
Journal Info :
Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
MeSH Terms :
Antidotes*
Models, Genetic*
Drosophila Proteins/*genetics
Gene Drive Technology/*methods
Protein Engineering/*methods
Animals ; Animals, Genetically Modified ; CRISPR-Cas Systems/genetics ; Drosophila/genetics ; Female ; Genetics, Population ; Heterozygote ; Mutation
Czasopismo naukowe
Tytuł :
A CAR against CAR for unintended consequences.
Autorzy :
Neelapu SS; The University of Texas MD Anderson Cancer Center.
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Źródło :
Blood [Blood] 2020 Feb 13; Vol. 135 (7), pp. 460-462.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Comment
Journal Info :
Publisher: American Society of Hematology Country of Publication: United States NLM ID: 7603509 Publication Model: Print Cited Medium: Internet ISSN: 1528-0020 (Electronic) Linking ISSN: 00064971 NLM ISO Abbreviation: Blood Subsets: Core Clinical (AIM); MEDLINE
MeSH Terms :
Antidotes*
Receptors, Chimeric Antigen*
Czasopismo naukowe
Tytuł :
New alternative to antidotes for novel oral anticoagulants and ticagrelor in the case of severe bleeding.
Autorzy :
Honore PM; ICU Department, Centre Hospitalier Universitaire Brugmann-Brugmann University Hospital, Place Van Gehuchtenplein, 4, 1020, Brussels, Belgium. .
David C; ICU Department, Centre Hospitalier Universitaire Brugmann-Brugmann University Hospital, Place Van Gehuchtenplein, 4, 1020, Brussels, Belgium.
Attou R; ICU Department, Centre Hospitalier Universitaire Brugmann-Brugmann University Hospital, Place Van Gehuchtenplein, 4, 1020, Brussels, Belgium.
Redant S; ICU Department, Centre Hospitalier Universitaire Brugmann-Brugmann University Hospital, Place Van Gehuchtenplein, 4, 1020, Brussels, Belgium.
Gallerani A; ICU Department, Centre Hospitalier Universitaire Brugmann-Brugmann University Hospital, Place Van Gehuchtenplein, 4, 1020, Brussels, Belgium.
De Bels D; ICU Department, Centre Hospitalier Universitaire Brugmann-Brugmann University Hospital, Place Van Gehuchtenplein, 4, 1020, Brussels, Belgium.
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Źródło :
Critical care (London, England) [Crit Care] 2020 Feb 11; Vol. 24 (1), pp. 48. Date of Electronic Publication: 2020 Feb 11.
Typ publikacji :
Letter; Comment
Journal Info :
Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 9801902 Publication Model: Electronic Cited Medium: Internet ISSN: 1466-609X (Electronic) Linking ISSN: 13648535 NLM ISO Abbreviation: Crit Care Subsets: MEDLINE
MeSH Terms :
Antidotes*
Ticagrelor*
Anticoagulants ; Cerebral Hemorrhage ; Humans
Opinia redakcyjna
Tytuł :
[Simplified N-acetylcystein treatment after paracetamol overdose - new recommendations from Swedish Poisons Information Centre].
Transliterated Title :
Ny förenklad motgiftsbehandling vid förgiftning med paracetamol - Giftinformationscentralen ändrar sin doseringsanvisning för N-acetylcystein.
Autorzy :
Nordmark Grass J; Giftinformationscentralen - Stockholm, Sweden Giftinformationscentralen - Stockholm, Sweden.
Lindeman E; Läkemedelsverket - Giftinformationscentralen Stockholm, Sweden Läkemedelsverket - Giftinformationscentralen Stockholm, Sweden.
Höjer J; - , Sweden - , Sweden.
Personne M; - Stockholm, Sweden - Stockholm, Sweden.
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Źródło :
Lakartidningen [Lakartidningen] 2019 Nov 01; Vol. 116. Date of Electronic Publication: 2019 Nov 01.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Sveriges Lakarforbund Country of Publication: Sweden NLM ID: 0027707 Publication Model: Electronic Cited Medium: Internet ISSN: 1652-7518 (Electronic) Linking ISSN: 00237205 NLM ISO Abbreviation: Lakartidningen Subsets: MEDLINE
MeSH Terms :
Acetaminophen/*poisoning
Acetylcysteine/*administration & dosage
Antidotes/*administration & dosage
Drug Overdose/*drug therapy
Poisoning/*drug therapy
Acetylcysteine/adverse effects ; Acetylcysteine/therapeutic use ; Administration, Intravenous ; Antidotes/adverse effects ; Antidotes/therapeutic use ; Humans ; Poison Control Centers ; Practice Guidelines as Topic
Czasopismo naukowe
Tytuł :
Coordinating emergent procedures after andexanet alfa.
Autorzy :
Culbreth SE; Department of Pharmacy Services, Brigham and Women's Hospital, Boston, Massachusetts.
Sylvester KW; Department of Pharmacy Services, Brigham and Women's Hospital, Boston, Massachusetts.
Rimsans J; Department of Pharmacy Services, Brigham and Women's Hospital, Boston, Massachusetts.
Connors JM; Department of Medicine, Division of Hematology, Brigham and Women's Hospital, Boston, Massachusetts.
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Źródło :
American journal of hematology [Am J Hematol] 2019 Oct; Vol. 94 (10), pp. E278-E282. Date of Electronic Publication: 2019 Aug 10.
Typ publikacji :
Letter
Journal Info :
Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 7610369 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-8652 (Electronic) Linking ISSN: 03618609 NLM ISO Abbreviation: Am. J. Hematol. Subsets: MEDLINE
MeSH Terms :
Emergencies*
Premedication*
Antidotes/*therapeutic use
Factor Xa/*therapeutic use
Factor Xa Inhibitors/*adverse effects
Hemorrhage/*drug therapy
Recombinant Proteins/*therapeutic use
Antidotes/administration & dosage ; Antidotes/pharmacokinetics ; Blood Coagulation Factors/therapeutic use ; Blood Component Transfusion ; Blood Loss, Surgical ; Cerebral Hemorrhage/drug therapy ; Drug Administration Schedule ; Factor Xa/administration & dosage ; Factor Xa/pharmacokinetics ; Hemorrhage/chemically induced ; Hemorrhage/etiology ; Hemorrhage/therapy ; Humans ; Intraoperative Care ; Preoperative Care ; Pyrazoles/adverse effects ; Pyrazoles/antagonists & inhibitors ; Pyrazoles/therapeutic use ; Pyridones/adverse effects ; Pyridones/antagonists & inhibitors ; Pyridones/therapeutic use ; Recombinant Proteins/administration & dosage ; Recombinant Proteins/pharmacokinetics ; Rivaroxaban/adverse effects ; Rivaroxaban/antagonists & inhibitors ; Rivaroxaban/therapeutic use ; Wounds and Injuries/complications
Opinia redakcyjna
Tytuł :
Naloxone nasal spray - bioavailability and absorption pattern in a phase 1 study.
Transliterated Title :
Naloksonnesespray – biotilgjengelighet og opptaksmønster i en fase 1-studie.
Autorzy :
Tylleskar I
Skulberg AK
Nilsen T
Skarra S
Dale O
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Źródło :
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke [Tidsskr Nor Laegeforen] 2019 Sep 23; Vol. 139 (13). Date of Electronic Publication: 2019 Sep 23 (Print Publication: 2019).
Typ publikacji :
Clinical Trial, Phase I; Journal Article; Randomized Controlled Trial
Journal Info :
Publisher: Norske Laegeforening Country of Publication: Norway NLM ID: 0413423 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 0807-7096 (Electronic) Linking ISSN: 00292001 NLM ISO Abbreviation: Tidsskr. Nor. Laegeforen. Subsets: MEDLINE
MeSH Terms :
Antidotes*/administration & dosage
Antidotes*/pharmacokinetics
Naloxone*/administration & dosage
Naloxone*/pharmacokinetics
Nasal Sprays*
Administration, Intravenous ; Adult ; Analgesics, Opioid/poisoning ; Biological Availability ; Cross-Over Studies ; Drug Overdose/drug therapy ; Gas Chromatography-Mass Spectrometry ; Humans ; Male ; Pilot Projects ; Tandem Mass Spectrometry ; Young Adult
Czasopismo naukowe
Tytuł :
Specific Antidotes for Direct Oral Anticoagulant Reversal: Case Closed or Cold Case?
Autorzy :
Godier A; Service d'Anesthésie-Réanimation, Hôpital Européen Georges Pompidou, AP-HP, Paris, France (A.G.).; Inserm UMR-S1140, Faculté de Pharmacie, Université Paris Descartes, France (A.G., A.C.M.).
Martin AC; Inserm UMR-S1140, Faculté de Pharmacie, Université Paris Descartes, France (A.G., A.C.M.).; Service de Cardiologie, Hôpital Européen Georges Pompidou, AP-HP, Paris, France (A.C.M.).
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Źródło :
Circulation [Circulation] 2019 Oct 29; Vol. 140 (18), pp. 1445-1447. Date of Electronic Publication: 2019 Oct 28.
Typ publikacji :
Journal Article; Review
Journal Info :
Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0147763 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4539 (Electronic) Linking ISSN: 00097322 NLM ISO Abbreviation: Circulation Subsets: Core Clinical (AIM); MEDLINE
MeSH Terms :
Administration, Oral*
Anticoagulants/*therapeutic use
Antidotes/*therapeutic use
Anticoagulants/economics ; Antidotes/economics ; Dabigatran/therapeutic use ; Humans
Czasopismo naukowe
Tytuł :
Andexanet Alfa for Urgent Reversal of Apixaban Before Aortic Surgery Requiring Cardiopulmonary Bypass: A Case Report.
Autorzy :
Flaherty D; From the Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Connors JM; Division of Hematology, Brigham and Women's Hospital, Boston, Massachusetts.
Singh S; Division of Cardiac Surgery, Trillium Health Partners, University of Toronto, Toronto, Ontario, Canada.
Sylvester KW; Division of Pharmacy, Brigham and Women's Hospital, Boston, Massachusetts.
Rimsans J; Division of Pharmacy, Brigham and Women's Hospital, Boston, Massachusetts.
Cornella L; From the Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
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Źródło :
A&A practice [A A Pract] 2019 Oct 01; Vol. 13 (7), pp. 271-273.
Typ publikacji :
Case Reports; Journal Article
Journal Info :
Publisher: Wolters Kluwer Health, Inc Country of Publication: United States NLM ID: 101714112 Publication Model: Print Cited Medium: Internet ISSN: 2575-3126 (Electronic) Linking ISSN: 25753126 NLM ISO Abbreviation: A A Pract Subsets: MEDLINE
MeSH Terms :
Aneurysm, False/*surgery
Antidotes/*administration & dosage
Aorta, Thoracic/*surgery
Factor Xa/*administration & dosage
Recombinant Proteins/*administration & dosage
Antidotes/therapeutic use ; Cardiopulmonary Bypass ; Factor Xa/therapeutic use ; Humans ; Middle Aged ; Pyrazoles ; Pyridones ; Recombinant Proteins/therapeutic use ; Treatment Outcome
Czasopismo naukowe
Tytuł :
EDTA-modified mesoporous silica as supra adsorbent of copper ions with novel approach as an antidote agent in copper toxicity.
Autorzy :
Taqanaki ER; Department of Medical Nanotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran.
Heidari R; Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Monfared M; Department of Medical Nanotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran.; Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
Tayebi L; School of Dentistry, Marquette University, Milwaukee, WI, USA.
Azadi A; Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.; Department of Pharmaceutics, Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
Farjadian F; Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
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Źródło :
International journal of nanomedicine [Int J Nanomedicine] 2019 Sep 26; Vol. 14, pp. 7781-7792. Date of Electronic Publication: 2019 Sep 26 (Print Publication: 2019).
Typ publikacji :
Journal Article
Journal Info :
Publisher: DOVE Medical Press Country of Publication: New Zealand NLM ID: 101263847 Publication Model: eCollection Cited Medium: Internet ISSN: 1178-2013 (Electronic) Linking ISSN: 11769114 NLM ISO Abbreviation: Int J Nanomedicine Subsets: MEDLINE
MeSH Terms :
Antidotes/*pharmacology
Copper/*isolation & purification
Copper/*toxicity
Edetic Acid/*chemistry
Silicon Dioxide/*chemistry
Adsorption ; Animals ; Antidotes/administration & dosage ; Biomarkers/blood ; Copper/blood ; Diffusion ; Ions ; Kinetics ; Mice ; Models, Animal ; Particle Size ; Porosity ; Spectroscopy, Fourier Transform Infrared ; X-Ray Diffraction
Czasopismo naukowe
Tytuł :
Behavioural and physiological assessments of dimethyl trisulfide treatment for acute oral sodium cyanide poisoning.
Autorzy :
Rice NC; United States Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Maryland.
Rauscher NA; United States Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Maryland.
Wilkins WL; United States Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Maryland.
Lippner DS; United States Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Maryland.
Rockwood GA; United States Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Maryland.
Myers TM; United States Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Maryland.
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Źródło :
Basic & clinical pharmacology & toxicology [Basic Clin Pharmacol Toxicol] 2019 Sep; Vol. 125 (3), pp. 289-303. Date of Electronic Publication: 2019 Apr 10.
Typ publikacji :
Evaluation Study; Journal Article
Journal Info :
Publisher: Blackwell Country of Publication: England NLM ID: 101208422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1742-7843 (Electronic) Linking ISSN: 17427835 NLM ISO Abbreviation: Basic Clin. Pharmacol. Toxicol. Subsets: MEDLINE
MeSH Terms :
Antidotes/*administration & dosage
First Aid/*methods
Poisoning/*drug therapy
Sodium Cyanide/*poisoning
Sulfides/*administration & dosage
Administration, Oral ; Animals ; Antidotes/adverse effects ; Behavior Observation Techniques ; Behavior, Animal/drug effects ; Disease Models, Animal ; Humans ; Injections, Intramuscular ; Lethal Dose 50 ; Male ; Mass Casualty Incidents ; Models, Neurological ; Poisoning/mortality ; Poisoning/psychology ; Rats ; Sodium Cyanide/administration & dosage ; Sulfides/adverse effects ; Survival Analysis ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Attenuation of cardiac ischemia-reperfusion injury by sodium thiosulfate is partially dependent on the effect of cystathione beta synthase in the myocardium.
Autorzy :
Kannan S; School of Chemical and Biotechnology, SASTRA Deemed University, Thanjavur, India.
Boovarahan SR; School of Chemical and Biotechnology, SASTRA Deemed University, Thanjavur, India.
Rengaraju J; School of Chemical and Biotechnology, SASTRA Deemed University, Thanjavur, India.
Prem P; School of Chemical and Biotechnology, SASTRA Deemed University, Thanjavur, India.
Kurian GA; School of Chemical and Biotechnology, SASTRA Deemed University, Thanjavur, India. .
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Źródło :
Cell biochemistry and biophysics [Cell Biochem Biophys] 2019 Sep; Vol. 77 (3), pp. 261-272. Date of Electronic Publication: 2019 May 07.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Humana Press Country of Publication: United States NLM ID: 9701934 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-0283 (Electronic) Linking ISSN: 10859195 NLM ISO Abbreviation: Cell Biochem. Biophys. Subsets: MEDLINE
MeSH Terms :
Antidotes/*pharmacology
Apoptosis/*drug effects
Cystathionine gamma-Lyase/*metabolism
Myocardium/*enzymology
Thiosulfates/*pharmacology
Alkynes/pharmacology ; Animals ; Antidotes/therapeutic use ; Antioxidants/chemistry ; Cell Hypoxia ; Cell Line ; Cell Survival/drug effects ; Cystathionine gamma-Lyase/antagonists & inhibitors ; Glycine/analogs & derivatives ; Glycine/pharmacology ; Heart/drug effects ; Hydrogen Sulfide/metabolism ; Lipid Peroxidation/drug effects ; Male ; Mice ; Mitochondria/drug effects ; Myocardial Reperfusion Injury/metabolism ; Myocardial Reperfusion Injury/pathology ; Myocardial Reperfusion Injury/prevention & control ; Rats ; Rats, Wistar ; Thiosulfates/therapeutic use
Czasopismo naukowe
Tytuł :
Efficacy of Oral Administration of Sodium Thiosulfate and Glycine in a Large, Swine Model of Oral Cyanide Toxicity.
Autorzy :
Ng PC; Rocky Mountain Poison and Drug Center, Denver Health and Hospital Authority, Denver, CO; Department of Emergency Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO. Electronic address: .
Hendry-Hofer TB; Department of Emergency Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO.
Witeof AE; Department of Emergency Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO.
Mahon SB; Laser Microbeam and Medical Program, Beckman Laser Institute and Medical Clinic, University of California, Irvine, CA.
Brenner M; Laser Microbeam and Medical Program, Beckman Laser Institute and Medical Clinic, University of California, Irvine, CA; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, Irvine, CA.
Boss GR; Department of Medicine, University of California, San Diego, CA.
Bebarta VS; Rocky Mountain Poison and Drug Center, Denver Health and Hospital Authority, Denver, CO; Department of Emergency Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO.
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Źródło :
Annals of emergency medicine [Ann Emerg Med] 2019 Sep; Vol. 74 (3), pp. 423-429. Date of Electronic Publication: 2019 May 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Mosby Country of Publication: United States NLM ID: 8002646 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-6760 (Electronic) Linking ISSN: 01960644 NLM ISO Abbreviation: Ann Emerg Med Subsets: Core Clinical (AIM); MEDLINE
MeSH Terms :
Antidotes/*administration & dosage
Glycine/*administration & dosage
Potassium Cyanide/*poisoning
Thiosulfates/*administration & dosage
Administration, Oral ; Animals ; Antidotes/pharmacokinetics ; Disease Models, Animal ; Drug Therapy, Combination ; Female ; Glycine/pharmacology ; Humans ; Poisons ; Random Allocation ; Swine ; Thiosulfates/pharmacology ; Time Factors
Czasopismo naukowe

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