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Tytuł :
Development of an Antigen-Antibody Co-Display System for Detecting Interaction of G-Protein-Coupled Receptors and Single-Chain Variable Fragments.
Autorzy :
Zhang Y; Laboratory of Regeneromics, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China.
Wu BJ; Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, WA 99210, USA.
Yu X; Shanghai Municipality Key Laboratory of Veterinary Biotechnology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China.
Luo P; Laboratory of Regeneromics, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China.
Ye H; Laboratory of Regeneromics, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China.
Yu Y; Shanghai Municipality Key Laboratory of Veterinary Biotechnology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China.
Han W; Laboratory of Regeneromics, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China.
Li J; Laboratory of Regeneromics, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Apr 29; Vol. 22 (9). Date of Electronic Publication: 2021 Apr 29.
Typ publikacji :
Journal Article
MeSH Terms :
Antigen-Antibody Reactions*
Two-Hybrid System Techniques*
Immobilized Proteins/*immunology
Receptors, G-Protein-Coupled/*immunology
Single-Chain Antibodies/*immunology
Antibodies, Immobilized/immunology ; Colorimetry ; DNA-Binding Proteins ; Epitopes/immunology ; Genes, Reporter ; Humans ; Membrane Proteins ; Protein Interaction Domains and Motifs ; Receptors, CXCR4/immunology ; Receptors, CXCR5/immunology ; Recombinant Fusion Proteins/immunology ; Saccharomyces cerevisiae Proteins ; Transcription Factors ; Ubiquitin/genetics
Czasopismo naukowe
Tytuł :
Ultrasensitive, high-throughput, and rapid simultaneous detection of SARS-CoV-2 antigens and IgG/IgM antibodies within 10 min through an immunoassay biochip.
Autorzy :
Wang C; Institute of Marine Science and Technology, Shandong University, Qingdao, 266000, China.
Wang C; Institute of Marine Science and Technology, Shandong University, Qingdao, 266000, China.
Qiu J; Institute of Marine Science and Technology, Shandong University, Qingdao, 266000, China.
Gao J; Institute of Marine Science and Technology, Shandong University, Qingdao, 266000, China.
Liu H; Institute of Crystal Materials, Shandong University, Jinan, 250100, Shandong, China.
Zhang Y; Institute of Marine Science and Technology, Shandong University, Qingdao, 266000, China. .
Han L; Institute of Marine Science and Technology, Shandong University, Qingdao, 266000, China. .
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Źródło :
Mikrochimica acta [Mikrochim Acta] 2021 Jul 20; Vol. 188 (8), pp. 262. Date of Electronic Publication: 2021 Jul 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunoassay*
Antigens, Viral/*blood
Immunoglobulin G/*blood
Immunoglobulin M/*blood
SARS-CoV-2/*isolation & purification
Antigen-Antibody Reactions ; Antigens, Viral/immunology ; Humans ; Immunoglobulin G/immunology ; Immunoglobulin M/immunology ; Nanoparticles/chemistry ; Particle Size ; SARS-CoV-2/immunology ; Sensitivity and Specificity
Czasopismo naukowe
Tytuł :
Dynamic Profiling of Binding and Allosteric Propensities of the SARS-CoV-2 Spike Protein with Different Classes of Antibodies: Mutational and Perturbation-Based Scanning Reveals the Allosteric Duality of Functionally Adaptable Hotspots.
Autorzy :
Verkhivker G; Keck Center for Science and Engineering, Schmid College of Science and Technology, Chapman University, One University Drive, Orange, California 92866, United States.; Depatment of Biomedical and Pharmaceutical Sciences, Chapman University School of Pharmacy, Irvine, California 92618, United States.
Agajanian S; Keck Center for Science and Engineering, Schmid College of Science and Technology, Chapman University, One University Drive, Orange, California 92866, United States.
Oztas D; Keck Center for Science and Engineering, Schmid College of Science and Technology, Chapman University, One University Drive, Orange, California 92866, United States.
Gupta G; Keck Center for Science and Engineering, Schmid College of Science and Technology, Chapman University, One University Drive, Orange, California 92866, United States.
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Źródło :
Journal of chemical theory and computation [J Chem Theory Comput] 2021 Jul 13; Vol. 17 (7), pp. 4578-4598. Date of Electronic Publication: 2021 Jun 17.
Typ publikacji :
Journal Article
MeSH Terms :
Antibodies, Viral/*chemistry
Spike Glycoprotein, Coronavirus/*chemistry
Spike Glycoprotein, Coronavirus/*immunology
Antigen-Antibody Reactions ; Antigens, Viral/chemistry ; Binding Sites ; Humans ; Models, Molecular ; Molecular Dynamics Simulation ; Mutation/genetics ; Protein Conformation ; Spike Glycoprotein, Coronavirus/genetics ; Stereoisomerism
Czasopismo naukowe
Tytuł :
Preparation of the peroxisome proliferator-activated receptor α polyclonal antibody: Its application in fatty liver hemorrhagic syndrome.
Autorzy :
Chen W; Jiangxi Provincial Key Laboratory for Animal Health, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, Jiangxi, China.
Shi Y; School of Computer and Information Engineering, Jiangxi Agricultural University, Nanchang, Jiangxi, China.
Li G; Jiangxi Provincial Key Laboratory for Animal Health, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, Jiangxi, China.
Huang C; Jiangxi Provincial Key Laboratory for Animal Health, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, Jiangxi, China.
Zhuang Y; Jiangxi Provincial Key Laboratory for Animal Health, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, Jiangxi, China.
Shu B; Jiangxi Provincial Key Laboratory for Animal Health, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, Jiangxi, China.
Cao X; Jiangxi Provincial Key Laboratory for Animal Health, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, Jiangxi, China.
Li Z; Jiangxi Provincial Key Laboratory for Animal Health, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, Jiangxi, China.
Hu G; Jiangxi Provincial Key Laboratory for Animal Health, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, Jiangxi, China.
Liu P; Jiangxi Provincial Key Laboratory for Animal Health, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, Jiangxi, China.
Guo X; Jiangxi Provincial Key Laboratory for Animal Health, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, Jiangxi, China. Electronic address: .
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2021 Jul 01; Vol. 182, pp. 179-186. Date of Electronic Publication: 2021 Apr 07.
Typ publikacji :
Journal Article
MeSH Terms :
Antibodies/*immunology
Fatty Liver/*veterinary
Hemorrhage/*veterinary
PPAR alpha/*metabolism
Poultry Diseases/*metabolism
Animals ; Antigen-Antibody Reactions ; Blotting, Western/methods ; Cells, Cultured ; Chickens ; Fatty Liver/metabolism ; Female ; Hemorrhage/metabolism ; Hepatocytes/metabolism ; Hypothalamus/metabolism ; Immunohistochemistry/methods ; Kidney/metabolism ; PPAR alpha/genetics ; PPAR alpha/immunology ; Syndrome
Czasopismo naukowe
Tytuł :
Glycan reactive anti-HIV-1 antibodies bind the SARS-CoV-2 spike protein but do not block viral entry.
Autorzy :
Mannar D; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada.
Leopold K; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada.
Subramaniam S; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada. .
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Źródło :
Scientific reports [Sci Rep] 2021 Jun 14; Vol. 11 (1), pp. 12448. Date of Electronic Publication: 2021 Jun 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
HIV Antibodies/*immunology
Polysaccharides/*immunology
SARS-CoV-2/*metabolism
Spike Glycoprotein, Coronavirus/*immunology
Antigen-Antibody Reactions ; COVID-19/pathology ; COVID-19/virology ; Cross Reactions ; Epitopes/immunology ; HIV Antibodies/pharmacology ; Humans ; SARS-CoV-2/isolation & purification ; Virus Internalization/drug effects
Czasopismo naukowe
Tytuł :
B cell genomics behind cross-neutralization of SARS-CoV-2 variants and SARS-CoV.
Autorzy :
Scheid JF; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Barnes CO; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Eraslan B; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA.
Hudak A; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA.
Keeffe JR; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Cosimi LA; Division of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Brown EM; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Muecksch F; Laboratory of Molecular Virology, The Rockefeller University, New York, NY 10065, USA.
Weisblum Y; Laboratory of Molecular Virology, The Rockefeller University, New York, NY 10065, USA.
Zhang S; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA.
Delorey T; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Woolley AE; Division of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Ghantous F; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.
Park SM; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA.
Phillips D; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Tusi B; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA.
Huey-Tubman KE; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Cohen AA; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Gnanapragasam PNP; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Rzasa K; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA.
Hatziioanno T; Laboratory of Molecular Virology, The Rockefeller University, New York, NY 10065, USA.
Durney MA; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA.
Gu X; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA.
Tada T; Department of Microbiology, NYU Grossman School of Medicine, New York, NY 10016, USA.
Landau NR; Department of Microbiology, NYU Grossman School of Medicine, New York, NY 10016, USA.
West AP Jr; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Rozenblatt-Rosen O; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Seaman MS; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.
Baden LR; Division of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Graham DB; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Deguine J; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA.
Bieniasz PD; Laboratory of Molecular Virology, The Rockefeller University, New York, NY 10065, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA.
Regev A; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA.
Hung D; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Bjorkman PJ; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA. Electronic address: .
Xavier RJ; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Electronic address: .
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Źródło :
Cell [Cell] 2021 Jun 10; Vol. 184 (12), pp. 3205-3221.e24. Date of Electronic Publication: 2021 Apr 24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Neutralizing/*immunology
B-Lymphocytes/*metabolism
SARS-CoV-2/*immunology
Spike Glycoprotein, Coronavirus/*immunology
Antibodies, Monoclonal/chemistry ; Antibodies, Monoclonal/immunology ; Antibodies, Neutralizing/blood ; Antibodies, Neutralizing/chemistry ; Antibodies, Viral/blood ; Antibodies, Viral/chemistry ; Antibodies, Viral/immunology ; Antigen-Antibody Complex/chemistry ; Antigen-Antibody Complex/metabolism ; Antigen-Antibody Reactions ; B-Lymphocytes/cytology ; B-Lymphocytes/virology ; COVID-19/pathology ; COVID-19/virology ; Cryoelectron Microscopy ; Crystallography, X-Ray ; Gene Expression Profiling ; Humans ; Immunoglobulin A/immunology ; Immunoglobulin Variable Region/chemistry ; Immunoglobulin Variable Region/genetics ; Protein Domains/immunology ; Protein Multimerization ; Protein Structure, Quaternary ; SARS-CoV-2/isolation & purification ; SARS-CoV-2/metabolism ; Sequence Analysis, RNA ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/metabolism
SCR Organism :
SARS-CoV-2 variants
Czasopismo naukowe
Tytuł :
Synthetic Homogeneous Glycoforms of the SARS-CoV-2 Spike Receptor-Binding Domain Reveals Different Binding Profiles of Monoclonal Antibodies.
Autorzy :
Ye F; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Jiao Tong University, Shanghai, 200240, China.
Zhao J; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Jiao Tong University, Shanghai, 200240, China.
Xu P; State Key Laboratory of Bioorganic and Natural Product Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 200032, China.
Liu X; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Jiao Tong University, Shanghai, 200240, China.
Yu J; State Key Laboratory of Bioorganic and Natural Product Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 200032, China.
Shangguan W; State Key Laboratory of Bioorganic and Natural Product Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 200032, China.
Liu J; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Jiao Tong University, Shanghai, 200240, China.
Luo X; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Jiao Tong University, Shanghai, 200240, China.
Li C; Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.
Ying T; Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.
Wang J; State Key Laboratory of Bioorganic and Natural Product Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 200032, China.; Institutes for Life Sciences, School of Medicine and National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangdong, 510006, China.
Yu B; State Key Laboratory of Bioorganic and Natural Product Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 200032, China.
Wang P; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Jiao Tong University, Shanghai, 200240, China.; Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, 200240, China.
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Źródło :
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2021 Jun 01; Vol. 60 (23), pp. 12904-12910. Date of Electronic Publication: 2021 Apr 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Monoclonal/*immunology
SARS-CoV-2/*metabolism
Spike Glycoprotein, Coronavirus/*immunology
Amino Acid Sequence ; Angiotensin-Converting Enzyme 2/chemistry ; Angiotensin-Converting Enzyme 2/metabolism ; Antigen-Antibody Reactions ; Binding Sites ; COVID-19/pathology ; COVID-19/virology ; Glycosylation ; Humans ; Kinetics ; Peptide Library ; Peptides/chemical synthesis ; Peptides/immunology ; Peptides/metabolism ; Protein Binding ; Protein Engineering ; Protein Folding ; Protein Structure, Tertiary ; SARS-CoV-2/isolation & purification ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
The basis of a more contagious 501Y.V1 variant of SARS-CoV-2.
Autorzy :
Liu H; Department of Immunology and Genomic Medicine, National Jewish Health, Denver, CO, 80206, USA. .; Department of Immunology and Microbiology, School of Medicine, Anschutz Medical Center, University of Colorado, Aurora, CO, 80216, USA. .
Zhang Q; State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agriculture University, Beijing, 100193, China.
Wei P; Department of Immunology and Genomic Medicine, National Jewish Health, Denver, CO, 80206, USA.; Department of Immunology and Microbiology, School of Medicine, Anschutz Medical Center, University of Colorado, Aurora, CO, 80216, USA.
Chen Z; State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agriculture University, Beijing, 100193, China.
Aviszus K; Department of Immunology and Genomic Medicine, National Jewish Health, Denver, CO, 80206, USA.; Department of Immunology and Microbiology, School of Medicine, Anschutz Medical Center, University of Colorado, Aurora, CO, 80216, USA.
Yang J; Department of Medicine, National Jewish Health, Denver, CO, 80206, USA.
Downing W; Department of Nursing, National Jewish Health, Denver, CO, 80206, USA.
Jiang C; Chinese Academy of Medical Sciences, Department of Biochemistry and Molecular Biology, Peking Union Medical College, Tsinghua University, Beijing, 100005, China.
Liang B; Department of Biochemistry, Emory University of School of Medicine, Atlanta, GA, 30322, USA.
Reynoso L; Department of Pharmacy, National Jewish Health, Denver, CO, 80206, USA.
Downey GP; Department of Medicine, National Jewish Health, Denver, CO, 80206, USA.
Frankel SK; Department of Medicine, National Jewish Health, Denver, CO, 80206, USA.
Kappler J; Department of Immunology and Genomic Medicine, National Jewish Health, Denver, CO, 80206, USA.; Department of Immunology and Microbiology, School of Medicine, Anschutz Medical Center, University of Colorado, Aurora, CO, 80216, USA.
Marrack P; Department of Immunology and Genomic Medicine, National Jewish Health, Denver, CO, 80206, USA. .; Department of Immunology and Microbiology, School of Medicine, Anschutz Medical Center, University of Colorado, Aurora, CO, 80216, USA. .
Zhang G; Department of Immunology and Genomic Medicine, National Jewish Health, Denver, CO, 80206, USA. .; Department of Immunology and Microbiology, School of Medicine, Anschutz Medical Center, University of Colorado, Aurora, CO, 80216, USA. .
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Źródło :
Cell research [Cell Res] 2021 Jun; Vol. 31 (6), pp. 720-722. Date of Electronic Publication: 2021 Apr 23.
Typ publikacji :
Letter; Research Support, N.I.H., Extramural
MeSH Terms :
SARS-CoV-2/*metabolism
Spike Glycoprotein, Coronavirus/*metabolism
Angiotensin-Converting Enzyme 2/chemistry ; Angiotensin-Converting Enzyme 2/metabolism ; Antibodies, Monoclonal, Humanized/immunology ; Antibodies, Neutralizing/immunology ; Antigen-Antibody Reactions ; COVID-19/pathology ; COVID-19/virology ; Humans ; Kinetics ; Mutation ; Protein Binding ; SARS-CoV-2/isolation & purification ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/immunology ; Surface Plasmon Resonance
SCR Organism :
SARS-CoV-2 variants
Raport
Tytuł :
Effects of heat treatment on the antigenicity, antigen epitopes, and structural properties of β-conglycinin.
Autorzy :
Li T; College of Food Science and Technology, Henan University of Technology, Zhengzhou 450001, China.
Bu G; College of Food Science and Technology, Henan University of Technology, Zhengzhou 450001, China. Electronic address: .
Xi G; College of Food Science and Technology, Henan University of Technology, Zhengzhou 450001, China.
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Źródło :
Food chemistry [Food Chem] 2021 Jun 01; Vol. 346, pp. 128962. Date of Electronic Publication: 2020 Dec 30.
Typ publikacji :
Journal Article
MeSH Terms :
Antigens, Plant/*immunology
Epitopes/*immunology
Globulins/*immunology
Seed Storage Proteins/*immunology
Soybean Proteins/*immunology
Antigen-Antibody Reactions ; Antigens, Plant/chemistry ; Antigens, Plant/metabolism ; Digestion ; Epitopes/chemistry ; Globulins/chemistry ; Globulins/metabolism ; Hot Temperature ; Hydrophobic and Hydrophilic Interactions ; Immunoglobulin E/immunology ; Immunoglobulin G/immunology ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Unfolding ; Seed Storage Proteins/chemistry ; Seed Storage Proteins/metabolism ; Soybean Proteins/chemistry ; Soybean Proteins/metabolism ; Spectrometry, Fluorescence ; Spectroscopy, Fourier Transform Infrared
Czasopismo naukowe
Tytuł :
Tropomyosin in mugwort cross-reacts to house dust mite, eliciting non-Th2 response in allergic rhinitis patients sensitized to house dust mite.
Autorzy :
Duan, Su (AUTHOR)
Zhao, Limin (AUTHOR)
Zhang, Yuling (AUTHOR)
Zhang, Nan (AUTHOR)
Zheng, Ming (AUTHOR)
Wang, Qiqi (AUTHOR)
Zhang, Xu (AUTHOR)
Wang, Xiangdong (AUTHOR)
Ying, Sun (AUTHOR)
Bachert, Claus (AUTHOR)
Zhang, Luo (AUTHOR)
Lan, Feng (AUTHOR)
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Źródło :
Clinical & Molecular Allergy. 4/2/2021, Vol. 19 Issue 1, p1-9. 9p.
Czasopismo naukowe
Tytuł :
Could antigen loss be a potential mechanism to explain antibody-mediated immune suppression?
Autorzy :
Cruz-Leal Y; Centre for Innovation, Canadian Blood Services, Ottawa, Ontario, Canada.; Department of Laboratory Medicine, The Keenan Research Centre for Biomedical Science in the Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, Ontario, Canada.
Lazarus AH; Centre for Innovation, Canadian Blood Services, Ottawa, Ontario, Canada.; Department of Laboratory Medicine, The Keenan Research Centre for Biomedical Science in the Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, Ontario, Canada.; Department of Medicine, University of Toronto, Toronto, Ontario, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
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Źródło :
Transfusion [Transfusion] 2021 Apr; Vol. 61 (4), pp. 1004-1006. Date of Electronic Publication: 2021 Feb 24.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antibody Formation/*immunology
Antigens/*immunology
Erythroblastosis, Fetal/*immunology
Immune Tolerance/*immunology
Antigen-Antibody Reactions/immunology ; Antigen-Antibody Reactions/physiology ; Erythrocytes/enzymology ; Erythrocytes/immunology ; Fetus/immunology ; Humans ; Immunosuppression/adverse effects ; Infant, Newborn ; Phagocytosis/immunology
Czasopismo naukowe
Tytuł :
Probe-target hybridization depends on spatial uniformity of initial concentration condition across large-format chips.
Autorzy :
Geldert A; UC Berkeley - UCSF Graduate Program in Bioengineering, Berkeley, United States.
Huang H; Department of Statistics, University of California Berkeley, Berkeley, California, 94720, United States.; Center for Computational Biology, University of California Berkeley, Berkeley, California, 94720, United States.
Herr AE; UC Berkeley - UCSF Graduate Program in Bioengineering, Berkeley, United States. .; Department of Bioengineering, University of California Berkeley, Berkeley, California, 94720, United States. .
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Źródło :
Scientific reports [Sci Rep] 2020 May 29; Vol. 10 (1), pp. 8768. Date of Electronic Publication: 2020 May 29.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Antigen-Antibody Reactions*
Nucleic Acid Hybridization*
Protein Array Analysis*
High-Throughput Screening Assays/*methods
Immunoassay/*methods
Immunohistochemistry/*methods
Antibody Affinity ; Brain Neoplasms/pathology ; Cell Line, Tumor ; Dose-Response Relationship, Drug ; Dose-Response Relationship, Immunologic ; Glioblastoma/pathology ; High-Throughput Screening Assays/instrumentation ; Humans ; Hydrogels ; Immunoblotting/instrumentation ; Immunoblotting/methods ; Single-Cell Analysis
Czasopismo naukowe
Tytuł :
The impact of different human IgG capture molecules on the kinetics analysis of antibody-antigen interaction.
Autorzy :
Kamat V; Biomolecular HTS Center, Therapeutic Proteins, Regeneron Pharmaceuticals, Tarrytown, NY, USA. Electronic address: .
Rafique A; Biomolecular HTS Center, Therapeutic Proteins, Regeneron Pharmaceuticals, Tarrytown, NY, USA.
Huang T; Therapeutic Proteins, Regeneron Pharmaceuticals, Tarrytown, NY, USA.
Olsen O; Therapeutic Proteins, Regeneron Pharmaceuticals, Tarrytown, NY, USA.
Olson W; Therapeutic Proteins, Regeneron Pharmaceuticals, Tarrytown, NY, USA.
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Źródło :
Analytical biochemistry [Anal Biochem] 2020 Mar 15; Vol. 593, pp. 113580. Date of Electronic Publication: 2020 Jan 10.
Typ publikacji :
Journal Article
MeSH Terms :
Antigen-Antibody Reactions*
Antibodies, Monoclonal/*immunology
Biosensing Techniques/*methods
Immunoglobulin Fc Fragments/*immunology
Immunoglobulin G/*immunology
Animals ; Goats ; Humans ; Kinetics ; Mice
Czasopismo naukowe
Tytuł :
Combining phenolic grafting and laccase-catalyzed cross-linking: Effects on structures, technofunctional properties and human immunoglobulin E binding capacity of egg white proteins.
Autorzy :
Li M; Department of Food Science and Agricultural Chemistry, Macdonald Campus, McGill University, Ste-Anne-de-Bellevue, Québec H9X 3V9, Canada.
Karboune S; Department of Food Science and Agricultural Chemistry, Macdonald Campus, McGill University, Ste-Anne-de-Bellevue, Québec H9X 3V9, Canada. Electronic address: .
Liu L; Department of Food Science and Agricultural Chemistry, Macdonald Campus, McGill University, Ste-Anne-de-Bellevue, Québec H9X 3V9, Canada.
Light K; Department of Food Science and Agricultural Chemistry, Macdonald Campus, McGill University, Ste-Anne-de-Bellevue, Québec H9X 3V9, Canada.
L'Hocine L; Agriculture and Agri-Food Canada, Casavant Blvd. West, St. Hyacinthe, QC J2S 8E3, Canada.
Achouri A; Agriculture and Agri-Food Canada, Casavant Blvd. West, St. Hyacinthe, QC J2S 8E3, Canada.
Pitre M; Agriculture and Agri-Food Canada, Casavant Blvd. West, St. Hyacinthe, QC J2S 8E3, Canada.
Mateo C; Department of Biocatalysis, Institute of Catalysis and Petrochemistry CSIC, Campus UAM, 28049 Madrid, Spain.
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Źródło :
Food chemistry [Food Chem] 2021 Sep 01; Vol. 355, pp. 129587. Date of Electronic Publication: 2021 Mar 13.
Typ publikacji :
Journal Article
MeSH Terms :
Immunoglobulin E/*immunology
Laccase/*metabolism
Muramidase/*immunology
Ovalbumin/*immunology
Phenols/*chemistry
Antigen-Antibody Reactions ; Biocatalysis ; Coumaric Acids/chemistry ; Cross-Linking Reagents/chemistry ; Humans ; Molecular Weight ; Muramidase/chemistry ; Ovalbumin/chemistry ; Oxidation-Reduction
Czasopismo naukowe
Tytuł :
A Single-Domain Antibody-Based Anti-PSMA Recombinant Immunotoxin Exhibits Specificity and Efficacy for Prostate Cancer Therapy.
Autorzy :
Xing Y; State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin 300071, China.
Xu K; State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin 300071, China.
Li S; State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin 300071, China.
Cao L; State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin 300071, China.
Nan Y; State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin 300071, China.
Li Q; State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin 300071, China.
Li W; State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin 300071, China.
Hong Z; State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin 300071, China.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 May 23; Vol. 22 (11). Date of Electronic Publication: 2021 May 23.
Typ publikacji :
Journal Article
MeSH Terms :
Molecular Targeted Therapy*
Adenocarcinoma/*drug therapy
Antigens, Neoplasm/*immunology
Antineoplastic Agents, Immunological/*therapeutic use
Glutamate Carboxypeptidase II/*antagonists & inhibitors
Immunotoxins/*therapeutic use
Prostatic Neoplasms/*drug therapy
Single-Domain Antibodies/*therapeutic use
Animals ; Antibody Specificity ; Antigen-Antibody Reactions ; Antigens, Surface/immunology ; Antineoplastic Agents, Immunological/toxicity ; Cell Line, Tumor ; Drug Screening Assays, Antitumor ; Glutamate Carboxypeptidase II/immunology ; Humans ; Immunotoxins/toxicity ; Male ; Maximum Tolerated Dose ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Models, Molecular ; Protein Conformation ; Recombinant Fusion Proteins/therapeutic use ; Recombinant Fusion Proteins/toxicity ; Single-Domain Antibodies/toxicity ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Implementing a method for engineering multivalency to substantially enhance binding of clinical trial anti-SARS-CoV-2 antibodies to wildtype spike and variants of concern proteins.
Autorzy :
Leach A; Institute of Cancer Research, 15 Cotswold Road, Sutton, London, SM2 5NG, UK.
Miller A; Institute of Cancer Research, 15 Cotswold Road, Sutton, London, SM2 5NG, UK.; Evotec, 114 Innovation Dr, Milton Park, Abingdon, OX14 4RZ, UK.
Bentley E; National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Hertfordshire, EN6 3QG, UK.
Mattiuzzo G; National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Hertfordshire, EN6 3QG, UK.
Thomas J; Institute of Cancer Research, 15 Cotswold Road, Sutton, London, SM2 5NG, UK.
McAndrew C; Institute of Cancer Research, 15 Cotswold Road, Sutton, London, SM2 5NG, UK.
Van Montfort R; Institute of Cancer Research, 15 Cotswold Road, Sutton, London, SM2 5NG, UK.
Rabbitts T; Institute of Cancer Research, 15 Cotswold Road, Sutton, London, SM2 5NG, UK. .
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Źródło :
Scientific reports [Sci Rep] 2021 May 18; Vol. 11 (1), pp. 10475. Date of Electronic Publication: 2021 May 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
SARS-CoV-2/*metabolism
Single-Chain Antibodies/*immunology
Spike Glycoprotein, Coronavirus/*immunology
Antibodies, Neutralizing/immunology ; Antibodies, Neutralizing/therapeutic use ; Antigen-Antibody Reactions ; COVID-19/drug therapy ; COVID-19/virology ; Enzyme-Linked Immunosorbent Assay ; HEK293 Cells ; Humans ; Neutralization Tests ; Protein Domains ; Protein Multimerization ; Recombinant Proteins/biosynthesis ; Recombinant Proteins/immunology ; Recombinant Proteins/isolation & purification ; Recombinant Proteins/therapeutic use ; SARS-CoV-2/immunology ; SARS-CoV-2/isolation & purification ; Single-Chain Antibodies/chemistry ; Single-Chain Antibodies/genetics ; Single-Chain Antibodies/therapeutic use ; Surface Plasmon Resonance ; Tumor Suppressor Protein p53/chemistry
SCR Organism :
SARS-CoV-2 variants
Czasopismo naukowe
Tytuł :
Substrates Modulate Charge-Reorganization Allosteric Effects in Protein-Protein Association.
Autorzy :
Ghosh S; Department of Chemical and Biological Physics, Weizmann Institute, Rehovot 76100, Israel.
Banerjee-Ghosh K; Department of Chemical and Biological Physics, Weizmann Institute, Rehovot 76100, Israel.
Levy D; Department of Chemical and Biological Physics, Weizmann Institute, Rehovot 76100, Israel.
Riven I; Department of Chemical and Biological Physics, Weizmann Institute, Rehovot 76100, Israel.
Naaman R; Department of Chemical and Biological Physics, Weizmann Institute, Rehovot 76100, Israel.
Haran G; Department of Chemical and Biological Physics, Weizmann Institute, Rehovot 76100, Israel.
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Źródło :
The journal of physical chemistry letters [J Phys Chem Lett] 2021 Mar 25; Vol. 12 (11), pp. 2805-2808. Date of Electronic Publication: 2021 Mar 12.
Typ publikacji :
Journal Article
MeSH Terms :
Phosphoglycerate Kinase/*metabolism
Adenosine Triphosphate/chemistry ; Adenosine Triphosphate/metabolism ; Allosteric Regulation ; Antibodies/immunology ; Antigen-Antibody Reactions ; Histidine/genetics ; Histidine/immunology ; Histidine/metabolism ; Oligopeptides/genetics ; Oligopeptides/immunology ; Oligopeptides/metabolism ; Phosphoglycerate Kinase/chemistry ; Phosphoglycerate Kinase/genetics ; Protein Conformation ; Recombinant Fusion Proteins/biosynthesis ; Recombinant Fusion Proteins/immunology ; Recombinant Fusion Proteins/isolation & purification ; Saccharomyces cerevisiae/enzymology ; Saccharomyces cerevisiae Proteins/chemistry ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism ; Substrate Specificity
Czasopismo naukowe
Tytuł :
Reciprocating-flowing on-a-chip enables ultra-fast immunobinding for multiplexed rapid ELISA detection of SARS-CoV-2 antibody.
Autorzy :
Liu Y; Key Laboratory of Sensing Technology and Biomedical Instruments of Guangdong Province, School of Biomedical Engineering, Sun Yat-sen University, Guangzhou, 510275, China.
Tan Y; Key Laboratory of Sensing Technology and Biomedical Instruments of Guangdong Province, School of Biomedical Engineering, Sun Yat-sen University, Guangzhou, 510275, China.
Fu Q; Key Laboratory of Sensing Technology and Biomedical Instruments of Guangdong Province, School of Biomedical Engineering, Sun Yat-sen University, Guangzhou, 510275, China.
Lin M; Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, 519000, China.
He J; Key Laboratory of Sensing Technology and Biomedical Instruments of Guangdong Province, School of Biomedical Engineering, Sun Yat-sen University, Guangzhou, 510275, China.
He S; Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, 519000, China.
Yang M; Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, 519000, China.
Chen S; Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, 519000, China. Electronic address: .
Zhou J; Key Laboratory of Sensing Technology and Biomedical Instruments of Guangdong Province, School of Biomedical Engineering, Sun Yat-sen University, Guangzhou, 510275, China. Electronic address: .
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Źródło :
Biosensors & bioelectronics [Biosens Bioelectron] 2021 Mar 15; Vol. 176, pp. 112920. Date of Electronic Publication: 2020 Dec 29.
Typ publikacji :
Journal Article
MeSH Terms :
Lab-On-A-Chip Devices*
COVID-19/*diagnosis
COVID-19 Serological Testing/*instrumentation
SARS-CoV-2/*immunology
Antibodies, Viral/blood ; Antigen-Antibody Reactions ; Biosensing Techniques/instrumentation ; COVID-19/immunology ; COVID-19/virology ; COVID-19 Serological Testing/methods ; Enzyme-Linked Immunosorbent Assay/instrumentation ; Equipment Design ; Humans ; Immobilized Proteins ; Pandemics
Czasopismo naukowe
Tytuł :
Technical report: xMAPr - High-dynamic-range (HDR) quantification of antigen-specific antibody binding.
Autorzy :
Meyer TC; Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Felix-Hausdorff-Straße 8, D-17475 Greifswald, Germany.
Schmidt F; Proteomics Core, Weill Cornell Medicine-Qatar, Qatar Foundation - Education City, PO 24144, Doha, Qatar.
Steinke J; Department of Immunology, University Medicine Greifswald, Ferdinand-Sauerbruch- Straße DZ7, D-17475 Greifswald, Germany.
Bröker BM; Department of Immunology, University Medicine Greifswald, Ferdinand-Sauerbruch- Straße DZ7, D-17475 Greifswald, Germany.
Völker U; Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Felix-Hausdorff-Straße 8, D-17475 Greifswald, Germany.
Michalik S; Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Felix-Hausdorff-Straße 8, D-17475 Greifswald, Germany. Electronic address: .
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Źródło :
Journal of proteomics [J Proteomics] 2020 Feb 10; Vol. 212, pp. 103577. Date of Electronic Publication: 2019 Nov 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Technical Report
MeSH Terms :
Antigen-Antibody Reactions*
Antibodies/*blood
Antigens/*metabolism
Blood Proteins/*metabolism
Fluorescent Dyes/*chemistry
Protein Array Analysis/*methods
Antibody Specificity ; Antigens/immunology ; Blood Proteins/immunology ; Humans ; Microspheres
Czasopismo naukowe
Tytuł :
A consensus protocol for the in silico optimisation of antibody fragments.
Autorzy :
Soler MA; International School for Advanced Studies (SISSA), Via Bonomea 265, 34136, Trieste, Italy. .
Medagli B
Semrau MS
Storici P
Bajc G
de Marco A
Laio A
Fortuna S
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Źródło :
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2019 Nov 19; Vol. 55 (93), pp. 14043-14046.
Typ publikacji :
Journal Article
MeSH Terms :
Antigen-Antibody Reactions*
Computer Simulation*
Single-Domain Antibodies/*chemistry
Single-Domain Antibodies/*immunology
Algorithms ; Humans ; Molecular Dynamics Simulation ; Mutation ; Receptor, ErbB-2/immunology ; Single-Domain Antibodies/genetics
Czasopismo naukowe

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