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Wyszukujesz frazę ""Antimetabolites, Antineoplastic"" wg kryterium: Temat


Tytuł :
Combination of DNA-hypomethylating agent and hematopoietic stem cell transplantation in treatment of juvenile myelomonocytic leukemia: A case report.
Autorzy :
Ai Y; Department of Pediatrics, West China Second University Hospital, Sichuan University.; Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, Sichuan University, Chengdu, Sichuan, China.
Lu X; Department of Pediatrics, West China Second University Hospital, Sichuan University.; Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, Sichuan University, Chengdu, Sichuan, China.
Zhu T; Department of Pediatrics, West China Second University Hospital, Sichuan University.; Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, Sichuan University, Chengdu, Sichuan, China.
Zhu Y; Department of Pediatrics, West China Second University Hospital, Sichuan University.; Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, Sichuan University, Chengdu, Sichuan, China.
Liu H; Department of Pediatrics, West China Second University Hospital, Sichuan University.; Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, Sichuan University, Chengdu, Sichuan, China.
Sun S; Department of Pediatrics, West China Second University Hospital, Sichuan University.; Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, Sichuan University, Chengdu, Sichuan, China.
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Źródło :
Medicine [Medicine (Baltimore)] 2020 Dec 11; Vol. 99 (50), pp. e23606.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Antimetabolites, Antineoplastic/*therapeutic use
Decitabine/*therapeutic use
Leukemia, Myelomonocytic, Juvenile/*diagnosis
Neoplasm Recurrence, Local/*diagnosis
Antimetabolites, Antineoplastic/administration & dosage ; Combined Modality Therapy ; Decitabine/administration & dosage ; Diagnosis, Differential ; Hematopoietic Stem Cell Transplantation ; Humans ; Infant ; Leukemia, Myelomonocytic, Juvenile/therapy ; Male ; Neoplasm Recurrence, Local/therapy
Czasopismo naukowe
Tytuł :
Sodium N-lauryl amino acids derived from silk protein can form catanionic aggregates with cytarabine as novel anti-tumor drug delivery systems.
Autorzy :
Zhang M; Silk Biotechnology Laboratory, School of Biology and Basic Medical Sciences, Soochow University, Suzhou, China.; National Engineering Laboratory for Modern Silk, Soochow University, Suzhou, China.
Zhao SX; Silk Biotechnology Laboratory, School of Biology and Basic Medical Sciences, Soochow University, Suzhou, China.; National Engineering Laboratory for Modern Silk, Soochow University, Suzhou, China.
Ding B; Silk Biotechnology Laboratory, School of Biology and Basic Medical Sciences, Soochow University, Suzhou, China.; National Engineering Laboratory for Modern Silk, Soochow University, Suzhou, China.
Zhang YQ; Silk Biotechnology Laboratory, School of Biology and Basic Medical Sciences, Soochow University, Suzhou, China.; National Engineering Laboratory for Modern Silk, Soochow University, Suzhou, China.
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Źródło :
Drug delivery [Drug Deliv] 2020 Dec; Vol. 27 (1), pp. 482-490.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Drug Delivery Systems*
Antimetabolites, Antineoplastic/*administration & dosage
Cytarabine/*administration & dosage
Silk/*chemistry
Amino Acids/chemistry ; Antimetabolites, Antineoplastic/pharmacology ; Cations ; Cell Line, Tumor ; Cytarabine/pharmacokinetics ; Delayed-Action Preparations ; Drug Carriers/chemistry ; Drug Liberation ; Humans ; Lymphoma/drug therapy ; Sericins/chemistry ; Surface-Active Agents/chemistry
Czasopismo naukowe
Tytuł :
Efficacy of Gemcitabine-based Chemotherapy in Clear Cell Sarcoma of Soft Tissue.
Autorzy :
Cojocaru E; Sarcoma Unit, The Royal Marsden Hospital, London, U.K.
Thway K; Sarcoma Unit, The Royal Marsden Hospital, London, U.K.; The Institute of Cancer Research, Chester Beatty Laboratories, London, U.K.
Fisher C; The Institute of Cancer Research, Chester Beatty Laboratories, London, U.K.; Department of Musculoskeletal Pathology, University Hospitals Birmingham, Birmingham, U.K.
Messiou C; The Institute of Cancer Research, Chester Beatty Laboratories, London, U.K.; Radiology Department, The Royal Marsden Hospital, London, U.K.
Zaidi S; Sarcoma Unit, The Royal Marsden Hospital, London, U.K.; The Institute of Cancer Research, Chester Beatty Laboratories, London, U.K.
Miah AB; Sarcoma Unit, The Royal Marsden Hospital, London, U.K.; The Institute of Cancer Research, Chester Beatty Laboratories, London, U.K.
Benson C; Sarcoma Unit, The Royal Marsden Hospital, London, U.K.
Gennatas S; Sarcoma Unit, The Royal Marsden Hospital, London, U.K.
Huang P; The Institute of Cancer Research, Chester Beatty Laboratories, London, U.K.
Jones RL; Sarcoma Unit, The Royal Marsden Hospital, London, U.K. .; The Institute of Cancer Research, Chester Beatty Laboratories, London, U.K. .
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Źródło :
Anticancer research [Anticancer Res] 2020 Dec; Vol. 40 (12), pp. 7003-7007.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Antimetabolites, Antineoplastic/*therapeutic use
Deoxycytidine/*analogs & derivatives
Sarcoma, Clear Cell/*drug therapy
Soft Tissue Neoplasms/*drug therapy
Adult ; Antimetabolites, Antineoplastic/pharmacology ; Deoxycytidine/pharmacology ; Deoxycytidine/therapeutic use ; Female ; Humans ; Male ; Middle Aged
Czasopismo naukowe
Tytuł :
No clear survival benefit of azacitidine for lower-risk myelodysplastic syndromes: A retrospective study of Nagasaki.
Autorzy :
Toriyama E; Department of Hematology, Atomic Bomb Disease and Hibakusha Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Hata T; Department of Hematology, Atomic Bomb Disease and Hibakusha Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan.
Yokota KI; Biostatistics Section, Division of Scientific Data Registry, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan.
Chiwata M; Department of Hematology, National Hospital Organization Nagasaki Medical Center, Ohmura, Japan.
Kamijo R; Department of Hematology, Sasebo City General Medical Center, Sasebo, Japan.
Hashimoto M; Department of Hematology, Atomic Bomb Disease and Hibakusha Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Taguchi M; Department of Hematology, Nagasaki University Hospital, Nagasaki, Japan.
Horai M; Department of Hematology, Nagasaki University Hospital, Nagasaki, Japan.
Matsuo M; Department of Hematology, Nagasaki Harbor Medical Center, Nagasaki, Japan.
Matsuo E; Department of Hematology, Japan Community Health Care Organization Isahaya General Hospital, Isahaya, Japan.
Takasaki Y; Department of Internal Medicine, Saint Francis Hospital, Nagasaki, Japan.
Kawaguchi Y; Department of Internal Medicine, National Hospital Organization Nagasaki Hospital, Nagasaki, Japan.
Itonaga H; Department of Hematology, Nagasaki University Hospital, Nagasaki, Japan.
Sato S; Department of Hematology, Nagasaki University Hospital, Nagasaki, Japan.
Ando K; Department of Hematology, Atomic Bomb Disease and Hibakusha Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan.
Sawayama Y; Department of Hematology, Nagasaki University Hospital, Nagasaki, Japan.
Taguchi J; Department of Hematology, Japanese Red Cross Nagasaki Genbaku Hospital, Nagasaki, Japan.
Imaizumi Y; Department of Hematology, Nagasaki University Hospital, Nagasaki, Japan.
Tsushima H; Department of Hematology, Nagasaki Harbor Medical Center, Nagasaki, Japan.
Jo T; Department of Hematology, Japanese Red Cross Nagasaki Genbaku Hospital, Nagasaki, Japan.
Yoshida S; Department of Hematology, National Hospital Organization Nagasaki Medical Center, Ohmura, Japan.
Moriuchi Y; Department of Hematology, Sasebo City General Medical Center, Sasebo, Japan.
Miyazaki Y; Department of Hematology, Atomic Bomb Disease and Hibakusha Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.; Department of Hematology, Atomic Bomb Disease and Hibakusha Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan.
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Źródło :
Cancer science [Cancer Sci] 2020 Dec; Vol. 111 (12), pp. 4490-4499. Date of Electronic Publication: 2020 Oct 23.
Typ publikacji :
Journal Article; Observational Study
MeSH Terms :
Antimetabolites, Antineoplastic/*therapeutic use
Azacitidine/*therapeutic use
Hematinics/*therapeutic use
Immunosuppressive Agents/*therapeutic use
Myelodysplastic Syndromes/*drug therapy
Adult ; Age Factors ; Aged ; Aged, 80 and over ; Antimetabolites, Antineoplastic/adverse effects ; Azacitidine/adverse effects ; Cause of Death ; Erythrocyte Transfusion/mortality ; Female ; Humans ; Induction Chemotherapy/methods ; Japan ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Multivariate Analysis ; Myelodysplastic Syndromes/mortality ; Platelet Transfusion/mortality ; Prognosis ; Regression Analysis ; Retrospective Studies ; Sex Factors ; Treatment Outcome ; Young Adult
Czasopismo naukowe
Tytuł :
Evaluation of metronomic chemotherapy response using diffusion and dynamic contrast-enhanced MRI.
Autorzy :
Baboli M; Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University School of Medicine, New York, New York, United States of America.; Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, New York, United States of America.
Winters KV; Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University School of Medicine, New York, New York, United States of America.; Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, New York, United States of America.
Freed M; Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University School of Medicine, New York, New York, United States of America.; Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, New York, United States of America.
Zhang J; Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University School of Medicine, New York, New York, United States of America.; Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, New York, United States of America.
Kim SG; Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University School of Medicine, New York, New York, United States of America.; Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, New York, United States of America.
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Źródło :
PloS one [PLoS One] 2020 Nov 25; Vol. 15 (11), pp. e0241916. Date of Electronic Publication: 2020 Nov 25 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Antimetabolites, Antineoplastic/*administration & dosage
Fluorouracil/*administration & dosage
Magnetic Resonance Imaging/*methods
Mammary Neoplasms, Animal/*diagnostic imaging
Mammary Neoplasms, Animal/*drug therapy
Administration, Metronomic ; Animals ; Antimetabolites, Antineoplastic/therapeutic use ; Case-Control Studies ; Contrast Media ; Diffusion Magnetic Resonance Imaging ; Feasibility Studies ; Female ; Fluorouracil/therapeutic use ; Longitudinal Studies ; Mice ; Mice, Inbred BALB C ; Neoplasm Metastasis ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Preclinical efficacy of gemcitabine in MLL-rearranged infant acute lymphoblastic leukemia.
Autorzy :
Wander P; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Department of Pediatric Oncology/Hematology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands.
Cheung LC; Telethon Kids Cancer Centre, Telethon Kids Institute, University of Western Australia, Perth, WA, Australia.; School of Pharmacy and Biomedical Sciences, Curtin University, Perth, WA, Australia.
Pinhanҫos SS; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; CNC-Center for Neurosciences and Cell Biology, University of Coimbra, Coimbra, Portugal.
Jones L; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Kerstjens M; Department of Pediatric Oncology/Hematology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands.
Arentsen-Peters STCJM; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Singh S; Telethon Kids Cancer Centre, Telethon Kids Institute, University of Western Australia, Perth, WA, Australia.
Chua GA; Telethon Kids Cancer Centre, Telethon Kids Institute, University of Western Australia, Perth, WA, Australia.
Castro PG; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Schneider P; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Dolman MEM; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Koopmans B; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Molenaar JJ; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Pieters R; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Zwaan CM; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Department of Pediatric Oncology/Hematology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands.
Kotecha RS; Telethon Kids Cancer Centre, Telethon Kids Institute, University of Western Australia, Perth, WA, Australia. .; School of Pharmacy and Biomedical Sciences, Curtin University, Perth, WA, Australia. .; Department of Haematology and Oncology, Perth Children's Hospital, Perth, WA, Australia. .
Stam RW; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands. .
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Źródło :
Leukemia [Leukemia] 2020 Nov; Vol. 34 (11), pp. 2898-2902. Date of Electronic Publication: 2020 Jun 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Rearrangement*
Antimetabolites, Antineoplastic/*pharmacology
Deoxycytidine/*analogs & derivatives
Myeloid-Lymphoid Leukemia Protein/*genetics
Precursor Cell Lymphoblastic Leukemia-Lymphoma/*genetics
Animals ; Antimetabolites, Antineoplastic/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Deoxycytidine/pharmacology ; Deoxycytidine/therapeutic use ; Disease Management ; Disease Models, Animal ; Drug Evaluation, Preclinical ; Genetic Predisposition to Disease ; Humans ; Infant ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/pathology
Czasopismo naukowe
Tytuł :
CPX-351 daunorubicin-cytarabine liposome: a novel formulation to treat patients with newly diagnosed secondary acute myeloid leukemia.
Autorzy :
Cafaro A; Unit of Oncological Pharmacy, IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), Meldola, Forlì-Cesena, Italy.
Giannini MB; Unit of Hematology, IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), Meldola, Forlì-Cesena, Italy.
Silimbani P; Unit of Oncological Pharmacy, IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), Meldola, Forlì-Cesena, Italy.
Cangini D; Unit of Hematology, IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), Meldola, Forlì-Cesena, Italy.
Masini C; Unit of Oncological Pharmacy, IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), Meldola, Forlì-Cesena, Italy.
Ghelli Luserna Di Rorà A; Laboratory of Biosciences, IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), Meldola, Forlì-Cesena, Italy.
Simonetti G; Laboratory of Biosciences, IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), Meldola, Forlì-Cesena, Italy.
Martinelli G; IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), Meldola, Forlì-Cesena, Italy.
Cerchione C; Unit of Hematology, IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), Meldola, Forlì-Cesena, Italy - .
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Źródło :
Minerva medica [Minerva Med] 2020 Oct; Vol. 111 (5), pp. 455-466. Date of Electronic Publication: 2020 Sep 21.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antimetabolites, Antineoplastic/*pharmacology
Cytarabine/*pharmacology
Daunorubicin/*pharmacology
Leukemia, Myeloid, Acute/*drug therapy
Age Factors ; Antimetabolites, Antineoplastic/administration & dosage ; Antimetabolites, Antineoplastic/pharmacokinetics ; Clinical Trials as Topic ; Cytarabine/administration & dosage ; Cytarabine/pharmacokinetics ; Daunorubicin/administration & dosage ; Daunorubicin/pharmacokinetics ; Humans ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/mortality ; Liposomes ; Middle Aged ; Mutation ; Myelodysplastic Syndromes/complications
Czasopismo naukowe
Tytuł :
Pharmacokinetics of gemcitabine and its amino acid ester prodrug following intravenous and oral administrations in mice.
Autorzy :
Thompson BR; Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA.
Shi J; Department of Clinical Pharmacy, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA.
Zhu HJ; Department of Clinical Pharmacy, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA.
Smith DE; Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2020 Oct; Vol. 180, pp. 114127. Date of Electronic Publication: 2020 Jun 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Amino Acids/*chemistry
Antimetabolites, Antineoplastic/*pharmacokinetics
Deoxycytidine/*analogs & derivatives
Prodrugs/*pharmacokinetics
Administration, Oral ; Animals ; Antimetabolites, Antineoplastic/administration & dosage ; Antimetabolites, Antineoplastic/blood ; Antimetabolites, Antineoplastic/chemistry ; Biological Availability ; Deoxycytidine/administration & dosage ; Deoxycytidine/blood ; Deoxycytidine/chemistry ; Deoxycytidine/pharmacokinetics ; Drug Stability ; Esters ; Injections, Intravenous ; Jejunum/metabolism ; Mice ; Mice, Inbred C57BL ; Molecular Structure ; Prodrugs/administration & dosage ; Prodrugs/chemistry
Czasopismo naukowe
Tytuł :
Do intravenous fluid substitutions influence methotrexate clearance? An unanticipated impact of an intravenous sodium bicarbonate drug shortage.
Autorzy :
Mangum R; Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, Texas.
Bernhardt MB; Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, Texas.
Cheng WS; Department of Public Heath, Benedictine University, Lisle, Illinois.
Schafer ES; Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, Texas.
Berg SL; Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, Texas.
Foster JH; Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, Texas.
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Źródło :
Pediatric blood & cancer [Pediatr Blood Cancer] 2020 Sep; Vol. 67 (9), pp. e28334. Date of Electronic Publication: 2020 Jul 01.
Typ publikacji :
Journal Article
MeSH Terms :
Antimetabolites, Antineoplastic/*pharmacokinetics
Methotrexate/*pharmacokinetics
Precursor Cell Lymphoblastic Leukemia-Lymphoma/*drug therapy
Sodium Bicarbonate/*therapeutic use
Administration, Intravenous ; Adolescent ; Antimetabolites, Antineoplastic/adverse effects ; Antimetabolites, Antineoplastic/therapeutic use ; Child ; Child, Preschool ; Female ; Humans ; Male ; Methotrexate/adverse effects ; Methotrexate/therapeutic use ; Retrospective Studies ; Sodium/administration & dosage ; Sodium Bicarbonate/administration & dosage
Czasopismo naukowe
Tytuł :
Does acute promyelocytic leukemia patient with the STAT5B/RARa fusion gene respond well to decitabine?: A case report and literature review.
Autorzy :
Wang L; Department of Hematology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, China.
Yan X
He J
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Źródło :
Medicine [Medicine (Baltimore)] 2020 Oct 23; Vol. 99 (43), pp. e22923.
Typ publikacji :
Case Reports; Journal Article; Review
MeSH Terms :
Antimetabolites, Antineoplastic/*therapeutic use
Decitabine/*therapeutic use
Leukemia, Promyelocytic, Acute/*drug therapy
Adolescent ; Adult ; Aged ; Antimetabolites, Antineoplastic/administration & dosage ; Antineoplastic Agents/adverse effects ; Antineoplastic Agents/therapeutic use ; Arsenic Trioxide/administration & dosage ; Arsenic Trioxide/therapeutic use ; Asian Continental Ancestry Group/genetics ; Consolidation Chemotherapy ; Cytarabine/administration & dosage ; Cytarabine/therapeutic use ; Decitabine/administration & dosage ; Drug Therapy, Combination ; Female ; Hospitalization ; Humans ; Idarubicin/administration & dosage ; Idarubicin/therapeutic use ; Leukemia, Promyelocytic, Acute/genetics ; Male ; Middle Aged ; Recurrence ; Retinoic Acid Receptor alpha/metabolism ; STAT5 Transcription Factor/metabolism ; Treatment Outcome ; Tretinoin/adverse effects ; Tretinoin/therapeutic use
Czasopismo naukowe
Tytuł :
5-Fluorouracil resistance mechanisms in colorectal cancer: From classical pathways to promising processes.
Autorzy :
Blondy S; Faculty of Medicine, Laboratoire EA3842 CAPTuR 'Control of cell activation, Tumor progression and Therapeutic resistance', Limoges cedex, France.
David V; Faculty of Medicine, Laboratoire EA3842 CAPTuR 'Control of cell activation, Tumor progression and Therapeutic resistance', Limoges cedex, France.; Department of pharmacy, University Hospital of Limoges, Limoges, France.
Verdier M; Faculty of Medicine, Laboratoire EA3842 CAPTuR 'Control of cell activation, Tumor progression and Therapeutic resistance', Limoges cedex, France.
Mathonnet M; Faculty of Medicine, Laboratoire EA3842 CAPTuR 'Control of cell activation, Tumor progression and Therapeutic resistance', Limoges cedex, France.; Service de Chirurgie Digestive, Department of Digestive, General and Endocrine Surgery, University Hospital of Limoges, Limoges, France.
Perraud A; Faculty of Medicine, Laboratoire EA3842 CAPTuR 'Control of cell activation, Tumor progression and Therapeutic resistance', Limoges cedex, France.; Service de Chirurgie Digestive, Department of Digestive, General and Endocrine Surgery, University Hospital of Limoges, Limoges, France.
Christou N; Faculty of Medicine, Laboratoire EA3842 CAPTuR 'Control of cell activation, Tumor progression and Therapeutic resistance', Limoges cedex, France.; Service de Chirurgie Digestive, Department of Digestive, General and Endocrine Surgery, University Hospital of Limoges, Limoges, France.
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Źródło :
Cancer science [Cancer Sci] 2020 Sep; Vol. 111 (9), pp. 3142-3154. Date of Electronic Publication: 2020 Aug 13.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Drug Resistance, Neoplasm*/genetics
Antimetabolites, Antineoplastic/*pharmacology
Colorectal Neoplasms/*metabolism
Fluorouracil/*pharmacology
Signal Transduction/*drug effects
Antimetabolites, Antineoplastic/metabolism ; Biomarkers ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology ; Energy Metabolism/drug effects ; Epigenesis, Genetic/drug effects ; Fluorouracil/metabolism ; Gene Expression Regulation, Neoplastic ; Humans ; Metabolic Networks and Pathways ; Oxidative Stress/drug effects ; Thymidylate Synthase/metabolism ; Tumor Microenvironment/drug effects ; Tumor Microenvironment/genetics
Czasopismo naukowe
Tytuł :
Pressure-enabled delivery of gemcitabine in an orthotopic pancreatic cancer mouse model.
Autorzy :
Shankara Narayanan JS; Moores Cancer Center, University of California San Diego, CA.
Vicente DA; Moores Cancer Center, University of California San Diego, CA.
Ray P; Moores Cancer Center, University of California San Diego, CA.
Chai LF; Immuno-oncology Institute and Department of Medicine, Roger Williams Medical Center, Providence, RI; Department of Surgery, Boston University School of Medicine, Boston, MA.
Erdem S; Moores Cancer Center, University of California San Diego, CA.
Carr MJ; Moores Cancer Center, University of California San Diego, CA.
Capacio BA; Moores Cancer Center, University of California San Diego, CA.
Cox BF; TriSalus Life Sciences, Westminster, CO.
Jaroch DB; TriSalus Life Sciences, Westminster, CO.
Katz SC; Immuno-oncology Institute and Department of Medicine, Roger Williams Medical Center, Providence, RI; Department of Surgery, Boston University School of Medicine, Boston, MA.
White RR; Moores Cancer Center, University of California San Diego, CA. Electronic address: .
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Źródło :
Surgery [Surgery] 2020 Sep; Vol. 168 (3), pp. 448-456. Date of Electronic Publication: 2020 Jun 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antimetabolites, Antineoplastic/*administration & dosage
Carcinoma, Pancreatic Ductal/*drug therapy
Deoxycytidine/*analogs & derivatives
Infusions, Intralesional/*methods
Pancreatic Neoplasms/*drug therapy
Animals ; Antimetabolites, Antineoplastic/pharmacokinetics ; Carcinoma, Pancreatic Ductal/pathology ; Cell Line, Tumor/transplantation ; Deoxycytidine/administration & dosage ; Deoxycytidine/pharmacokinetics ; Disease Models, Animal ; Humans ; Infusions, Intravenous/methods ; Male ; Mice ; Pancreas/blood supply ; Pancreas/pathology ; Pancreatic Neoplasms/pathology ; Pressure ; Tissue Distribution
Czasopismo naukowe
Tytuł :
Outcomes of decitabine treatment for newly diagnosed acute myeloid leukemia in older adults​.
Autorzy :
Yoo KH; Division of Hematology, Department of Internal Medicine, Gachon University Gil Medical Center, Gachon University College of Medicine, Incheon, Korea.
Cho J; Division of Hematology-Oncology, Department of Internal Medicine, Inha University Hospital, Inha University School of Medicine, Incheon, Korea.
Han B; Division of Hematology/Oncology, Department of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea.
Kim SH; Division of Hemato-Oncology, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Korea.
Shin DY; Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea.
Hong J; Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea.
Kim H; Division of Hematology, Department of Internal Medicine, Gachon University Gil Medical Center, Gachon University College of Medicine, Incheon, Korea.
Kim HJ; Division of Hematology/Oncology, Department of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea.
Zang DY; Division of Hematology/Oncology, Department of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea.
Yoon SS; Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea.
Jin JY; Division of Hemato-Oncology, Department of Internal Medicine, Bucheon St. Mary's Hospital, Bucheon, Korea.
Lee JH; Division of Hematology, Department of Internal Medicine, Gachon University Gil Medical Center, Gachon University College of Medicine, Incheon, Korea.
Hong DS; Division of Hemato-Oncology, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Korea.
Park SK; Division of Hemato-Oncology, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Korea.
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Źródło :
PloS one [PLoS One] 2020 Aug 06; Vol. 15 (8), pp. e0235503. Date of Electronic Publication: 2020 Aug 06 (Print Publication: 2020).
Typ publikacji :
Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Antimetabolites, Antineoplastic/*administration & dosage
Decitabine/*administration & dosage
Leukemia, Myeloid, Acute/*drug therapy
Remission Induction/*methods
Age Factors ; Aged ; Aged, 80 and over ; Antimetabolites, Antineoplastic/adverse effects ; Blood Cell Count ; Bone Marrow/pathology ; Decitabine/adverse effects ; Drug Administration Schedule ; Female ; Humans ; Leukemia, Myeloid, Acute/blood ; Leukemia, Myeloid, Acute/mortality ; Leukemia, Myeloid, Acute/pathology ; Male ; Nutrition Assessment ; Progression-Free Survival ; Republic of Korea/epidemiology ; Retrospective Studies ; Weight Loss
Czasopismo naukowe
Tytuł :
Eruptive Keratoacanthomas in a Red Tattoo.
Autorzy :
Linares-Gonzalez L; Department of Dermatology, Hospital Universitario San Cecilio, Granada, Spain.
Ródenas-Herranz T; Department of Dermatology, Hospital Universitario San Cecilio, Granada, Spain.
Galvez-Moreno M; Department of Dermatology, Hospital Universitario San Cecilio, Granada, Spain.
Ruiz-Villaverde R; Department of Dermatology, Hospital Universitario San Cecilio, Granada, Spain.
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Źródło :
Sultan Qaboos University medical journal [Sultan Qaboos Univ Med J] 2020 Aug; Vol. 20 (3), pp. e372-e373. Date of Electronic Publication: 2020 Oct 05.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Antimetabolites, Antineoplastic/*therapeutic use
Keratoacanthoma/*pathology
Methotrexate/*therapeutic use
Tattooing/*adverse effects
Aged ; Antimetabolites, Antineoplastic/administration & dosage ; Biopsy ; Diagnosis, Differential ; Female ; Humans ; Injections, Intralesional ; Keratoacanthoma/drug therapy ; Methotrexate/administration & dosage ; Treatment Outcome ; Ulcer/pathology
Czasopismo naukowe
Tytuł :
Solitary serum methotrexate level 36 hours post high-dose methotrexate: A safe, efficacious, and cost-effective strategy to monitor methotrexate toxicities in childhood leukemia in resource-limited centers.
Autorzy :
Khera S; Department of Pediatrics, Army Hospital Research and Referral, Delhi, 110010, India.
Kapoor R; Department of Hematology, Command Hospital Kolkata, Kolkata, West Bengal, India.
Pramanik SK; Department of Hematology, Army Hospital Research and Referral, Delhi, India.
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Źródło :
Pediatric blood & cancer [Pediatr Blood Cancer] 2020 Jul; Vol. 67 (7), pp. e28387. Date of Electronic Publication: 2020 May 13.
Typ publikacji :
Journal Article; Observational Study
MeSH Terms :
Cost-Benefit Analysis*
Antimetabolites, Antineoplastic/*economics
Drug-Related Side Effects and Adverse Reactions/*blood
Drug-Related Side Effects and Adverse Reactions/*economics
Methotrexate/*economics
Precursor Cell Lymphoblastic Leukemia-Lymphoma/*economics
Antimetabolites, Antineoplastic/adverse effects ; Antimetabolites, Antineoplastic/blood ; Child ; Child, Preschool ; Developing Countries ; Drug-Related Side Effects and Adverse Reactions/etiology ; Female ; Follow-Up Studies ; Humans ; Infant ; Male ; Methotrexate/adverse effects ; Methotrexate/blood ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Prognosis ; Prospective Studies
Czasopismo naukowe
Tytuł :
HER2 targeted biological macromolecule modified liposomes for improved efficacy of capecitabine in breast cancer.
Autorzy :
Singh MK; Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty, The Nilgiris, Tamil Nadu, India. Electronic address: .
Pindiprolu SKSS; Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty, The Nilgiris, Tamil Nadu, India; Department of Pharmacology, School of Pharmaceutical Sciences & Technologies, JNT University Kakinada, Kakinada, Andhra Pradesh, India.
Sanapalli BKR; Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty, The Nilgiris, Tamil Nadu, India.
Yele V; Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty, The Nilgiris, Tamil Nadu, India.
Ganesh GNK; Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty, The Nilgiris, Tamil Nadu, India. Electronic address: .
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2020 May 01; Vol. 150, pp. 631-636. Date of Electronic Publication: 2020 Feb 13.
Typ publikacji :
Journal Article
MeSH Terms :
Antimetabolites, Antineoplastic*/chemistry
Antimetabolites, Antineoplastic*/pharmacology
Breast Neoplasms*/drug therapy
Breast Neoplasms*/metabolism
Breast Neoplasms*/pathology
Chitosan*/chemistry
Chitosan*/pharmacology
Peptides*/chemistry
Peptides*/pharmacology
Receptor, ErbB-2*/agonists
Receptor, ErbB-2*/metabolism
Capecitabine/chemistry ; Capecitabine/pharmacology ; Cell Line, Tumor ; Female ; Humans ; Liposomes
Czasopismo naukowe
Tytuł :
Clinical efficacy and safety of 6-thioguanine in the treatment of childhood acute lymphoblastic leukemia: A protocol for systematic review and meta-analysis.
Autorzy :
Chen L; Department of Hematology, Inner Mongolia Baogang Hospital (The Third Affiliated Hospital of Inner Mongolia Medical University), No. 20 Shaoxian Road, Kundulun District, Baotou, Inner Mongolia Autonomous Region, 014010, China.
Yan HX
Liu XW
Chen WX
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Źródło :
Medicine [Medicine (Baltimore)] 2020 May; Vol. 99 (18), pp. e20082.
Typ publikacji :
Journal Article; Meta-Analysis; Systematic Review
MeSH Terms :
Antimetabolites, Antineoplastic/*therapeutic use
Precursor Cell Lymphoblastic Leukemia-Lymphoma/*drug therapy
Thioguanine/*therapeutic use
Adolescent ; Antimetabolites, Antineoplastic/administration & dosage ; Antimetabolites, Antineoplastic/adverse effects ; Child ; Child, Preschool ; Drug Substitution ; Humans ; Infant ; Mercaptopurine/therapeutic use ; Neoplasm Metastasis ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/pathology ; Randomized Controlled Trials as Topic ; Recurrence ; Research Design ; Thioguanine/administration & dosage ; Thioguanine/adverse effects
Czasopismo naukowe
Tytuł :
Recent Advances in Designing 5-Fluorouracil Delivery Systems: A Stepping Stone in the Safe Treatment of Colorectal Cancer.
Autorzy :
Entezar-Almahdi E; Department of Pharmaceutics, Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
Mohammadi-Samani S; Department of Pharmaceutics, Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.; Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Tayebi L; Marquette University, School of Dentistry, Milwaukee, WI, USA.
Farjadian F; Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
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Źródło :
International journal of nanomedicine [Int J Nanomedicine] 2020 Jul 30; Vol. 15, pp. 5445-5458. Date of Electronic Publication: 2020 Jul 30 (Print Publication: 2020).
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antimetabolites, Antineoplastic/*administration & dosage
Colorectal Neoplasms/*drug therapy
Drug Carriers/*chemistry
Drug Delivery Systems/*methods
Fluorouracil/*administration & dosage
Animals ; Antimetabolites, Antineoplastic/pharmacokinetics ; Antineoplastic Combined Chemotherapy Protocols/pharmacology ; Biological Availability ; Drug Carriers/therapeutic use ; Drug Resistance, Neoplasm/drug effects ; Fluorouracil/pharmacokinetics ; Humans ; Nanostructures/administration & dosage ; Nanostructures/chemistry
Czasopismo naukowe
Tytuł :
Protective effect of Andrographolide on 5-Fu induced intestinal mucositis by regulating p38 MAPK signaling pathway.
Autorzy :
Xiang DC; Department of Pharmacy, Tongji Hospital Affiliated with Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China; Department of Pharmacy, The Central Hospital of Wuhan,Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, China.
Yang JY; Department of Pharmacy, Tongji Hospital Affiliated with Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Xu YJ; Department of Pharmacy, Tongji Hospital Affiliated with Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Zhang S; Department of Pharmacy, Tongji Hospital Affiliated with Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Li M; Department of Pharmacy, Tongji Hospital Affiliated with Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Zhu C; Department of Pharmacy, Tongji Hospital Affiliated with Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Zhang CL; Department of Pharmacy, Tongji Hospital Affiliated with Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. Electronic address: .
Liu D; Department of Pharmacy, Tongji Hospital Affiliated with Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2020 Jul 01; Vol. 252, pp. 117612. Date of Electronic Publication: 2020 Apr 01.
Typ publikacji :
Journal Article
MeSH Terms :
Antimetabolites, Antineoplastic/*toxicity
Diterpenes/*administration & dosage
Fluorouracil/*toxicity
Intestinal Mucosa/*drug effects
Mucositis/*prevention & control
Animals ; Antimetabolites, Antineoplastic/pharmacology ; Apoptosis/drug effects ; Carcinoma, Hepatocellular/drug therapy ; Cell Proliferation/drug effects ; Diarrhea/chemically induced ; Diarrhea/prevention & control ; Disease Models, Animal ; Diterpenes/pharmacology ; Dose-Response Relationship, Drug ; Down-Regulation/drug effects ; Fluorouracil/pharmacology ; Humans ; Intestinal Mucosa/pathology ; Liver Neoplasms/drug therapy ; MAP Kinase Signaling System/drug effects ; Male ; Mice ; Mice, Inbred BALB C ; Mucositis/chemically induced ; p38 Mitogen-Activated Protein Kinases/metabolism
Czasopismo naukowe
Tytuł :
Activation of SIRT6 by DNA hypomethylating agents and clinical consequences on combination therapy in leukemia.
Autorzy :
Carraway HE; Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.
Malkaram SA; Department of Biology, West Virginia State University, Institute, WV, USA.
Cen Y; Department of Pharmaceutical Sciences, Albany College of Pharmacy, Colchester, VT, USA.; Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, VA, 23219, USA.
Shatnawi A; Department of Pharmaceutical & Administrative Sciences, University of Charleston, Charleston, WV, USA.
Fan J; Department of Biomedical Sciences, Marshall University, Huntington, WV, USA.
Ali HEA; Department of Pharmaceutical Sciences, Texas A&M University, Kingsville, TX, USA.
Abd Elmageed ZY; Department of Pharmaceutical Sciences, Texas A&M University, Kingsville, TX, USA.
Buttolph T; Department of Neurological Sciences, University of Vermont, Burlington, VT, USA.
Denvir J; Department of Biomedical Sciences, Marshall University, Huntington, WV, USA.
Primerano DA; Department of Biomedical Sciences, Marshall University, Huntington, WV, USA.
Fandy TE; Department of Pharmaceutical & Administrative Sciences, University of Charleston, Charleston, WV, USA. .
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Źródło :
Scientific reports [Sci Rep] 2020 Jun 25; Vol. 10 (1), pp. 10325. Date of Electronic Publication: 2020 Jun 25.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Antimetabolites, Antineoplastic/*pharmacology
Antineoplastic Combined Chemotherapy Protocols/*pharmacology
Leukemia, Myeloid, Acute/*drug therapy
Sirtuins/*metabolism
Acetylation/drug effects ; Antimetabolites, Antineoplastic/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Azacitidine/pharmacology ; Azacitidine/therapeutic use ; Bone Marrow/pathology ; Cell Line, Tumor ; Cytidine/analogs & derivatives ; Cytidine/pharmacology ; Cytidine/therapeutic use ; DNA Methylation/drug effects ; Decitabine/pharmacology ; Decitabine/therapeutic use ; Histones/metabolism ; Humans ; Leukemia, Myeloid, Acute/pathology
Czasopismo naukowe

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