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Tytuł:
Study on the activation of cell death mechanisms: in search of new therapeutic targets in glioblastoma multiforme.
Autorzy:
Gaiaschi L; Laboratory of Cell Biology and Neurobiology, Department of Biology and Biotechnology 'L. Spallanzani', University of Pavia, Via Ferrata 9, 27100, Pavia, Italy. .
Favaron C; Laboratory of Cell Biology and Neurobiology, Department of Biology and Biotechnology 'L. Spallanzani', University of Pavia, Via Ferrata 9, 27100, Pavia, Italy.
Casali C; Laboratory of Cell Biology and Neurobiology, Department of Biology and Biotechnology 'L. Spallanzani', University of Pavia, Via Ferrata 9, 27100, Pavia, Italy.
Gola F; Laboratory of Cell Biology and Neurobiology, Department of Biology and Biotechnology 'L. Spallanzani', University of Pavia, Via Ferrata 9, 27100, Pavia, Italy.
De Luca F; Laboratory of Cell Biology and Neurobiology, Department of Biology and Biotechnology 'L. Spallanzani', University of Pavia, Via Ferrata 9, 27100, Pavia, Italy.
Ravera M; Department of Sciences and Technological Innovation (DiSIT), University of Piemonte Orientale 'A. Avogadro', Viale Teresa Michel 11, 15121, Alessandria, Italy.
Roda E; Laboratory of Cell Biology and Neurobiology, Department of Biology and Biotechnology 'L. Spallanzani', University of Pavia, Via Ferrata 9, 27100, Pavia, Italy.; Laboratory of Clinical and Experimental Toxicology, Pavia Poison Centre, National Toxicology Information Centre, Toxicology Unit, ICS Maugeri Spa, IRCCS Pavia, Via Maugeri 10, Pavia, Italy.
Rossi P; Laboratory of Neurophysiology and Integrated Physiology, Department of Biology and Biotechnology 'L. Spallanzani', University of Pavia, Via Ferrata 9, 27100, Pavia, Italy.
Bottone MG; Laboratory of Cell Biology and Neurobiology, Department of Biology and Biotechnology 'L. Spallanzani', University of Pavia, Via Ferrata 9, 27100, Pavia, Italy.
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Źródło:
Apoptosis : an international journal on programmed cell death [Apoptosis] 2023 Aug; Vol. 28 (7-8), pp. 1241-1257. Date of Electronic Publication: 2023 May 27.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Glioblastoma*/drug therapy
Glioblastoma*/genetics
Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/therapeutic use
Brain Neoplasms*/drug therapy
Brain Neoplasms*/pathology
Humans ; Apoptosis ; Quality of Life ; Cell Death ; Cisplatin/pharmacology ; Cisplatin/therapeutic use ; Antineoplastic Agents, Alkylating/therapeutic use ; Histone Deacetylase Inhibitors/pharmacology ; Cell Line, Tumor
Czasopismo naukowe
Szczegóły
Tytuł:
From plant to cancer drug: lessons learned from the discovery of taxol.
Autorzy:
Cech NB; University of North Carolina Greensboro, USA. nadja_.
Oberlies NH; University of North Carolina Greensboro, USA. nadja_.
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Źródło:
Natural product reports [Nat Prod Rep] 2023 Jul 19; Vol. 40 (7), pp. 1153-1157. Date of Electronic Publication: 2023 Jul 19.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms:
Antineoplastic Agents, Phytogenic*/pharmacology
Antineoplastic Agents, Phytogenic*/chemistry
Biological Products*/chemistry
Neoplasms*/drug therapy
Humans ; Antineoplastic Agents ; Paclitaxel/pharmacology ; Paclitaxel/chemistry ; Plants ; Population Health
Czasopismo naukowe
Szczegóły
Tytuł:
Discovery of new imidazotetrazinones with potential to overcome tumor resistance.
Autorzy:
Summers HS; School of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
Lewis W; School of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
Williams HEL; School of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
Bradshaw TD; Biodiscovery Institute, School of Pharmacy, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
Moody CJ; School of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, UK. Electronic address: .
Stevens MFG; Biodiscovery Institute, School of Pharmacy, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
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Źródło:
European journal of medicinal chemistry [Eur J Med Chem] 2023 Sep 05; Vol. 257, pp. 115507. Date of Electronic Publication: 2023 May 21.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents*
Brain Neoplasms*/drug therapy
Glioblastoma*/drug therapy
Humans ; Temozolomide/pharmacology ; Dacarbazine/pharmacology ; Dacarbazine/therapeutic use ; Cell Line, Tumor ; Thiazoles/pharmacology ; Thiazoles/therapeutic use ; Antineoplastic Agents, Alkylating/therapeutic use ; Drug Resistance, Neoplasm
Czasopismo naukowe
Szczegóły
Tytuł:
The dinitrobenzamide mustard prodrugs, PR-104A and SN27686, for use in a novel MNDEPT cancer prodrug therapy approach.
Autorzy:
Ball P; School of Natural Sciences, Bangor University, Bangor, Gwynedd, Wales LL57 2UW, U.K.
Thompson E; School of Natural Sciences, Bangor University, Bangor, Gwynedd, Wales LL57 2UW, U.K.
Anderson S; School of Natural Sciences, Bangor University, Bangor, Gwynedd, Wales LL57 2UW, U.K.
Gwenin V; School of Natural Sciences, Bangor University, Bangor, Gwynedd, Wales LL57 2UW, U.K.
Ashoorzadeh A; Auckland Cancer Society Research Centre, School of Medical Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.
Smaill J; Auckland Cancer Society Research Centre, School of Medical Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.
Gwenin C; School of Natural Sciences, Bangor University, Bangor, Gwynedd, Wales LL57 2UW, U.K.; Division of Health Sciences, Abertay University, Bell Street, Dundee, DD1 1HG, U.K.
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Źródło:
Bioscience reports [Biosci Rep] 2023 Apr 26; Vol. 43 (4).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Prodrugs*/metabolism
Prodrugs*/pharmacology
Nitrogen Mustard Compounds*/metabolism
Neoplasms*
Antineoplastic Agents*/metabolism
Humans ; Antineoplastic Agents, Alkylating
Czasopismo naukowe
Szczegóły
Tytuł:
NMDA receptor signaling induces the chemoresistance of temozolomide via upregulation of MGMT expression in glioblastoma cells.
Autorzy:
Tsuji S; Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Gifu, Japan.
Nakamura S; Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Gifu, Japan.
Shoda K; Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Gifu, Japan.; Department of Neurosurgery, Gifu University Graduate School of Medicine, Gifu, Japan.
Yamada T; Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Gifu, Japan.; Department of Neurosurgery, Gifu University Graduate School of Medicine, Gifu, Japan.
Shimazawa M; Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Gifu, Japan.; Lab. Of Collaborative Research for Innovative Drug Discovery, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu, 501-1196, Japan.
Nakayama N; Department of Neurosurgery, Gifu University Graduate School of Medicine, Gifu, Japan.
Iwama T; Department of Neurosurgery, Gifu University Graduate School of Medicine, Gifu, Japan.
Hara H; Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Gifu, Japan. .; Lab. Of Collaborative Research for Innovative Drug Discovery, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu, 501-1196, Japan. .
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Źródło:
Journal of neuro-oncology [J Neurooncol] 2022 Nov; Vol. 160 (2), pp. 375-388. Date of Electronic Publication: 2022 Oct 29.
Typ publikacji:
Journal Article
MeSH Terms:
Glioblastoma*/drug therapy
Glioblastoma*/genetics
Glioblastoma*/metabolism
Antineoplastic Agents*/therapeutic use
Humans ; Temozolomide/pharmacology ; Temozolomide/therapeutic use ; Receptors, N-Methyl-D-Aspartate/genetics ; Receptors, N-Methyl-D-Aspartate/metabolism ; Receptors, N-Methyl-D-Aspartate/therapeutic use ; Drug Resistance, Neoplasm ; Up-Regulation ; Antineoplastic Agents, Alkylating/pharmacology ; Antineoplastic Agents, Alkylating/therapeutic use ; DNA Modification Methylases/metabolism ; O(6)-Methylguanine-DNA Methyltransferase/genetics ; DNA Repair Enzymes/metabolism ; DNA/pharmacology ; DNA/therapeutic use ; Cell Line, Tumor ; Tumor Suppressor Proteins/genetics ; Tumor Suppressor Proteins/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Assessment of antitumor activity of BP-C1, a platinum-based anticancer agent with a lignin-derived polymeric ligand, in autochthonous induced and spontaneous carcinogenesis rodent models.
Autorzy:
Fedoros EI; Department of Carcinogenesis and Oncogerontology, N.N. Petrov National Medical Research Center of Oncology, 68, Leningradskaya Str., Pesochny, Saint Petersburg 197758, Russia; Nobel Ltd., of. 333, 271A, pr. Obukhovskoy Oborony, Saint Petersburg 192012, Russia.
Tyndyk ML; Department of Carcinogenesis and Oncogerontology, N.N. Petrov National Medical Research Center of Oncology, 68, Leningradskaya Str., Pesochny, Saint Petersburg 197758, Russia.
Popovich IG; Department of Carcinogenesis and Oncogerontology, N.N. Petrov National Medical Research Center of Oncology, 68, Leningradskaya Str., Pesochny, Saint Petersburg 197758, Russia.
Anikin IV; Department of Carcinogenesis and Oncogerontology, N.N. Petrov National Medical Research Center of Oncology, 68, Leningradskaya Str., Pesochny, Saint Petersburg 197758, Russia.
Yurova MN; Department of Carcinogenesis and Oncogerontology, N.N. Petrov National Medical Research Center of Oncology, 68, Leningradskaya Str., Pesochny, Saint Petersburg 197758, Russia.
Gubareva EA; Department of Carcinogenesis and Oncogerontology, N.N. Petrov National Medical Research Center of Oncology, 68, Leningradskaya Str., Pesochny, Saint Petersburg 197758, Russia.
Pigarev SE; Department of Carcinogenesis and Oncogerontology, N.N. Petrov National Medical Research Center of Oncology, 68, Leningradskaya Str., Pesochny, Saint Petersburg 197758, Russia; Nobel Ltd., of. 333, 271A, pr. Obukhovskoy Oborony, Saint Petersburg 192012, Russia.
Panchenko AV; Department of Carcinogenesis and Oncogerontology, N.N. Petrov National Medical Research Center of Oncology, 68, Leningradskaya Str., Pesochny, Saint Petersburg 197758, Russia.
Solovyev ND; Atlantic Technological University, ATU Sligo, Ash Lane, Sligo F91 YW50, Ireland. Electronic address: .
Anisimov VN; Department of Carcinogenesis and Oncogerontology, N.N. Petrov National Medical Research Center of Oncology, 68, Leningradskaya Str., Pesochny, Saint Petersburg 197758, Russia.
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Źródło:
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) [J Trace Elem Med Biol] 2022 Sep; Vol. 73, pp. 127013. Date of Electronic Publication: 2022 May 31.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/therapeutic use
Benzo(a)pyrene*
1,2-Dimethylhydrazine ; Animals ; Antineoplastic Agents, Alkylating ; Carcinogenesis ; Carcinogens ; Female ; Ligands ; Lignin ; Mice ; Mice, Inbred Strains ; Platinum ; Rats ; Rats, Wistar ; Rodentia
Czasopismo naukowe
Szczegóły
Tytuł:
A phase 1 safety and bioimaging trial of antibody DS-8895a against EphA2 in patients with advanced or metastatic EphA2 positive cancers.
Autorzy:
Gan HK; Tumour Targeting Laboratory, Olivia Newton-John Cancer Research Institute, Melbourne, Australia. .; School of Cancer Medicine, La Trobe University, Melbourne, Australia. .; Department of Medical Oncology, Austin Health, Melbourne, Australia. .
Parakh S; Tumour Targeting Laboratory, Olivia Newton-John Cancer Research Institute, Melbourne, Australia.; School of Cancer Medicine, La Trobe University, Melbourne, Australia.; Department of Medical Oncology, Austin Health, Melbourne, Australia.
Lee FT; Tumour Targeting Laboratory, Olivia Newton-John Cancer Research Institute, Melbourne, Australia.
Tebbutt NC; Department of Medical Oncology, Austin Health, Melbourne, Australia.
Ameratunga M; Department of Medical Oncology, Austin Health, Melbourne, Australia.
Lee ST; Tumour Targeting Laboratory, Olivia Newton-John Cancer Research Institute, Melbourne, Australia.; School of Cancer Medicine, La Trobe University, Melbourne, Australia.; Department of Molecular Imaging and Therapy, Austin Health, Melbourne, Australia.; Faculty of Medicine, University of Melbourne, Melbourne, Australia.
O'Keefe GJ; Tumour Targeting Laboratory, Olivia Newton-John Cancer Research Institute, Melbourne, Australia.; Department of Molecular Imaging and Therapy, Austin Health, Melbourne, Australia.
Gong SJ; Tumour Targeting Laboratory, Olivia Newton-John Cancer Research Institute, Melbourne, Australia.; Department of Molecular Imaging and Therapy, Austin Health, Melbourne, Australia.
Vanrenen C; Department of Medical Oncology, Austin Health, Melbourne, Australia.
Caine J; Department of Medical Oncology, Austin Health, Melbourne, Australia.
Giovannetti M; Ludwig Cancer Research, New York, NY, USA.
Murone C; Tumour Targeting Laboratory, Olivia Newton-John Cancer Research Institute, Melbourne, Australia.
Scott FE; Tumour Targeting Laboratory, Olivia Newton-John Cancer Research Institute, Melbourne, Australia.; School of Cancer Medicine, La Trobe University, Melbourne, Australia.
Guo N; Tumour Targeting Laboratory, Olivia Newton-John Cancer Research Institute, Melbourne, Australia.
Burvenich IJG; Tumour Targeting Laboratory, Olivia Newton-John Cancer Research Institute, Melbourne, Australia.; School of Cancer Medicine, La Trobe University, Melbourne, Australia.
Paine C; Department of Molecular Imaging and Therapy, Austin Health, Melbourne, Australia.
Macri MJ; Ludwig Cancer Research, New York, NY, USA.
Kotsuma M; Daiichi Sankyo, Inc, Basking Ridge, NJ, USA.
Senaldi G; Daiichi Sankyo, Inc, Basking Ridge, NJ, USA.
Venhaus R; Ludwig Cancer Research, New York, NY, USA.
Scott AM; Tumour Targeting Laboratory, Olivia Newton-John Cancer Research Institute, Melbourne, Australia.; School of Cancer Medicine, La Trobe University, Melbourne, Australia.; Department of Molecular Imaging and Therapy, Austin Health, Melbourne, Australia.; Faculty of Medicine, University of Melbourne, Melbourne, Australia.
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Źródło:
Investigational new drugs [Invest New Drugs] 2022 Aug; Vol. 40 (4), pp. 747-755. Date of Electronic Publication: 2022 Apr 11.
Typ publikacji:
Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antibodies, Monoclonal, Humanized*/pharmacokinetics
Antibodies, Monoclonal, Humanized*/therapeutic use
Antineoplastic Agents, Immunological*/pharmacokinetics
Antineoplastic Agents, Immunological*/therapeutic use
Neoplasms*/diagnostic imaging
Neoplasms*/drug therapy
Aged ; Aged, 80 and over ; Antibodies, Monoclonal ; Antineoplastic Agents ; Ephrin-A2/immunology ; Humans ; Male ; Middle Aged ; Receptor, EphA2/drug effects ; Tissue Distribution
Czasopismo naukowe
Szczegóły
Tytuł:
Recent advances in immune checkpoint inhibitor-induced type 1 diabetes mellitus.
Autorzy:
Liao D; Department of Pharmacy, Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410011, China.
Liu C; Department of Information, Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410011, China.
Chen S; Department of Pharmacy, Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410011, China.
Liu F; Department of Pharmacy, Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410011, China.
Li W; Department of Pharmacy, Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410011, China.
Shangguan D; Department of Pharmacy, Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410011, China. Electronic address: .
Shi Y; Department of Radiation Oncology, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410011, China. Electronic address: .
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Źródło:
International immunopharmacology [Int Immunopharmacol] 2023 Sep; Vol. 122, pp. 110414. Date of Electronic Publication: 2023 Jun 28.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Diabetes Mellitus, Type 1*/chemically induced
Diabetes Mellitus, Type 1*/drug therapy
Antineoplastic Agents, Immunological*/therapeutic use
Antineoplastic Agents*/therapeutic use
Neoplasms*/drug therapy
Humans ; Immune Checkpoint Inhibitors/adverse effects
Czasopismo naukowe
Szczegóły
Tytuł:
Triterpenoid saponins from Camellia sinensis roots with cytotoxic and immunomodulatory effects.
Autorzy:
Lee J; College of Pharmacy, Kangwon National University, Chuncheon, 24341, South Korea.
Lim JH; Division of Life Sciences, College of Life Science and Bioengineering, Incheon National University, Incheon, 22012, South Korea.
Jung GY; Division of Life Sciences, College of Life Science and Bioengineering, Incheon National University, Incheon, 22012, South Korea.
Kang J; College of Pharmacy, Kangwon National University, Chuncheon, 24341, South Korea.
Jo I; College of Pharmacy, Kangwon National University, Chuncheon, 24341, South Korea.
Kang K; Division of Life Sciences, College of Life Science and Bioengineering, Incheon National University, Incheon, 22012, South Korea.
Kim JH; Department of Pharmacology, School of Medicine, Institute of Health Sciences, Gyeongsang National University, Jinju, 52727, South Korea. Electronic address: .
Kim BS; Division of Life Sciences, College of Life Science and Bioengineering, Incheon National University, Incheon, 22012, South Korea. Electronic address: .
Yang H; College of Pharmacy, Kangwon National University, Chuncheon, 24341, South Korea. Electronic address: .
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Źródło:
Phytochemistry [Phytochemistry] 2023 Aug; Vol. 212, pp. 113688. Date of Electronic Publication: 2023 Apr 28.
Typ publikacji:
Journal Article
MeSH Terms:
Camellia sinensis*
Triterpenes*/pharmacology
Triterpenes*/chemistry
Antineoplastic Agents, Phytogenic*/chemistry
Saponins*/pharmacology
Saponins*/chemistry
Antineoplastic Agents*
Camellia*/chemistry
Humans ; Animals ; Mice ; Sugars
Czasopismo naukowe
Szczegóły
Tytuł:
Novel Cytotoxic Sesquiterpene Coumarin Ethers and Sulfur-Containing Compounds from the Roots of Ferula turcica .
Autorzy:
Eruçar FM; Department of Pharmacognosy, Faculty of Pharmacy, Istanbul University, Istanbul 34116, Türkiye.; Department of Pharmacognosy, Institute of Graduate Studies in Health Sciences, Istanbul University, Istanbul 34116, Türkiye.; Molecular Targets Program, National Institutes of Health, National Cancer Institute, Frederick, MD 21702, USA.
Senadeera SPD; Molecular Targets Program, National Institutes of Health, National Cancer Institute, Frederick, MD 21702, USA.
Wilson JA; Molecular Targets Program, National Institutes of Health, National Cancer Institute, Frederick, MD 21702, USA.
Goncharova E; Molecular Targets Program, National Institutes of Health, National Cancer Institute, Frederick, MD 21702, USA.; Advanced Biomedical Computational Science, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
Beutler JA; Molecular Targets Program, National Institutes of Health, National Cancer Institute, Frederick, MD 21702, USA.
Miski M; Department of Pharmacognosy, Faculty of Pharmacy, Istanbul University, Istanbul 34116, Türkiye.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2023 Jul 28; Vol. 28 (15). Date of Electronic Publication: 2023 Jul 28.
Typ publikacji:
Journal Article
MeSH Terms:
Ferula*/chemistry
Antineoplastic Agents, Phytogenic*/pharmacology
Antineoplastic Agents*/analysis
Anesthetics, General*
Sesquiterpenes*/chemistry
Sulfur Compounds/analysis ; Molecular Structure ; Ethers ; Coumarins/chemistry ; Sulfur/analysis ; Plant Roots/chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Ursane-Type Triterpenes with a Phenylpropanoid Unit from Camellia ptilosperma and Evaluation of Their Cytotoxic Activities.
Autorzy:
Ma S; School of Chemistry & Chemical Engineering, Guangxi University, Nanning 530004, China.
Ge L; Medical College of Guangxi University, Nanning 530004, China.
Li Y; Medical College of Guangxi University, Nanning 530004, China.
Liao N; Guangxi Fangcheng Golden Camellias National Nature Reserve Management Center, Fangchenggang 538021, China.
Xie J; School of Pharmaceutical Science, Guangxi Medical University, Nanning 530021, China.
Yang K; School of Chemistry & Chemical Engineering, Guangxi University, Nanning 530004, China.; Medical College of Guangxi University, Nanning 530004, China.
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Źródło:
Journal of natural products [J Nat Prod] 2023 Jul 28; Vol. 86 (7), pp. 1793-1800. Date of Electronic Publication: 2023 Jun 26.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Triterpenes*/pharmacology
Triterpenes*/chemistry
Camellia*/chemistry
Antineoplastic Agents, Phytogenic*/pharmacology
Antineoplastic Agents, Phytogenic*/chemistry
Antineoplastic Agents*
Humans ; Animals ; Mice ; Molecular Structure ; Cell Line, Tumor
Czasopismo naukowe
Szczegóły
Tytuł:
Schomburginones A‒J, geranylated benzophenones from the leaves of Garcinia schomburgkiana and their cytotoxic and anti-inflammatory activities.
Autorzy:
Sukandar ER; Center of Excellence in Natural Products Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand. Electronic address: .
Kaennakam S; Department of Agro-Industrial, Food, and Environmental Technology, Faculty of Applied Science, King Mongkut's University of Technology North Bangkok (KMUTNB), Bangkok, 10800, Thailand.
Wongsuwan S; Center of Excellence in Natural Products Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand.
Chatwichien J; Program in Chemical Sciences, Chulabhorn Graduate Institute, Chulabhorn Royal Academy, Bangkok, 10210, Thailand.
Krobthong S; Center of Excellence in Natural Products Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand; Center for Neuroscience, Faculty of Science, Mahidol University, Bangkok, 10400, Thailand.
Yingchutrakul Y; Center for Neuroscience, Faculty of Science, Mahidol University, Bangkok, 10400, Thailand; National Omics Center (NOC), NSTDA, Pathum Thani, 12120, Thailand.
Mahatnirunkul T; National Nanotechnology Center (NANOTEC), 111 Thailand Science Park, Phahonyothin Rd, Klong Nueng, Klong Luang, Pathum Thani, 12120, Thailand.
Mulya F; Center of Excellence in Computational Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand.
Parasuk V; Center of Excellence in Computational Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand.
Harding DJ; School of Chemistry, Institute of Science, Suranaree University of Technology, Nakhon Ratchasima, 30000, Thailand.
Poldorn P; Center of Excellence in Biocatalyst and Sustainable Biotechnology, Department of Biochemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand.
Rungrotmongkol T; Center of Excellence in Biocatalyst and Sustainable Biotechnology, Department of Biochemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand; Program in Bioinformatics and Computational Biology, Graduate School, Chulalongkorn University, Bangkok, 10330, Thailand.
Tip-Pyang S; Center of Excellence in Natural Products Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand.
Aonbangkhen C; Center of Excellence in Natural Products Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand.
Chavasiri W; Center of Excellence in Natural Products Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand. Electronic address: .
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Źródło:
Phytochemistry [Phytochemistry] 2023 Jul; Vol. 211, pp. 113701. Date of Electronic Publication: 2023 Apr 29.
Typ publikacji:
Journal Article
MeSH Terms:
Garcinia*/chemistry
Antineoplastic Agents*
Antineoplastic Agents, Phytogenic*/pharmacology
Antineoplastic Agents, Phytogenic*/chemistry
Xanthones*/chemistry
Humans ; HeLa Cells ; Molecular Structure ; Benzophenones/pharmacology ; Benzophenones/chemistry
Czasopismo naukowe
Szczegóły
Tytuł:
Functionalized europium-doped hollow mesoporous silica nanospheres as a cell imaging and drug delivery agents.
Autorzy:
Shi G; Department of Molecular Imaging, School of Medical Technology, Qiqihar Medical University, Qiqihar, Heilongjiang, 161006, China.
Li Z; Department of Molecular Imaging, School of Medical Technology, Qiqihar Medical University, Qiqihar, Heilongjiang, 161006, China.
Zhang Z; Department of Molecular Imaging, School of Medical Technology, Qiqihar Medical University, Qiqihar, Heilongjiang, 161006, China.
Yin Q; Department of Molecular Imaging, School of Medical Technology, Qiqihar Medical University, Qiqihar, Heilongjiang, 161006, China.
Li N; Department of Imaging Medicine and Nuclear Medicine, School of Clinical Medicine, Jiamusi University, Jiamusi, Heilongjiang, 154002, China.
Wang S; Department of Molecular Imaging, School of Medical Technology, Qiqihar Medical University, Qiqihar, Heilongjiang, 161006, China.
Qi G; Department of Molecular Imaging, School of Medical Technology, Qiqihar Medical University, Qiqihar, Heilongjiang, 161006, China.
Hao L; Department of Molecular Imaging, School of Medical Technology, Qiqihar Medical University, Qiqihar, Heilongjiang, 161006, China. Electronic address: .
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Źródło:
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2023 Sep 24; Vol. 674, pp. 1-9. Date of Electronic Publication: 2023 Jun 26.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Nanospheres*
Breast Neoplasms*/drug therapy
Nanoparticles*
Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/therapeutic use
Humans ; Female ; Europium ; Silicon Dioxide ; Paclitaxel/pharmacology ; Drug Carriers ; Drug Delivery Systems ; Hyaluronic Acid
Czasopismo naukowe
Szczegóły
Tytuł:
The Power of Kinetic Inertness in Improving Platinum Anticancer Therapy by Circumventing Resistance and Ameliorating Nephrotoxicity.
Autorzy:
Panda TR; Laboratory of Medicinal Chemistry and Cell Biology, Department of Chemical Sciences, Tata Institute of Fundamental Research, Homi Bhabha Road, Navy Nagar, 400005, Mumbai, India.
M M; Laboratory of Medicinal Chemistry and Cell Biology, Department of Chemical Sciences, Tata Institute of Fundamental Research, Homi Bhabha Road, Navy Nagar, 400005, Mumbai, India.
Vaidya SP; Laboratory of Medicinal Chemistry and Cell Biology, Department of Chemical Sciences, Tata Institute of Fundamental Research, Homi Bhabha Road, Navy Nagar, 400005, Mumbai, India.
Chhatar S; Laboratory of Medicinal Chemistry and Cell Biology, Department of Chemical Sciences, Tata Institute of Fundamental Research, Homi Bhabha Road, Navy Nagar, 400005, Mumbai, India.
Sinha S; Institute of Pharmaceutical Research, GLA University, 7 km Stone, NH-2, Mathura-Delhi Road, Mathura, Uttar Pradesh, 281406, India.
Mehrotra M; Imaging Cell Signaling & Therapeutics Lab, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Sector 22, Kharghar, Navi Mumbai, 410210, Maharashtra, India.; Homi Bhabha National Institute, 2nd floor, BARC Training School Complex Anushaktinagar, Mumbai, 400094, Maharashtra, India.
Chakraborty S; Imaging Cell Signaling & Therapeutics Lab, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Sector 22, Kharghar, Navi Mumbai, 410210, Maharashtra, India.; Homi Bhabha National Institute, 2nd floor, BARC Training School Complex Anushaktinagar, Mumbai, 400094, Maharashtra, India.
Gadre S; Laboratory of Medicinal Chemistry and Cell Biology, Department of Chemical Sciences, Tata Institute of Fundamental Research, Homi Bhabha Road, Navy Nagar, 400005, Mumbai, India.
Duari P; Laboratory of Medicinal Chemistry and Cell Biology, Department of Chemical Sciences, Tata Institute of Fundamental Research, Homi Bhabha Road, Navy Nagar, 400005, Mumbai, India.
Ray P; Imaging Cell Signaling & Therapeutics Lab, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Sector 22, Kharghar, Navi Mumbai, 410210, Maharashtra, India.; Homi Bhabha National Institute, 2nd floor, BARC Training School Complex Anushaktinagar, Mumbai, 400094, Maharashtra, India.
Patra M; Laboratory of Medicinal Chemistry and Cell Biology, Department of Chemical Sciences, Tata Institute of Fundamental Research, Homi Bhabha Road, Navy Nagar, 400005, Mumbai, India.
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Źródło:
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2023 Sep 18; Vol. 62 (38), pp. e202303958. Date of Electronic Publication: 2023 Jul 11.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/therapeutic use
Neoplasms*/drug therapy
Humans ; Platinum/pharmacology ; Platinum/therapeutic use ; Cisplatin/pharmacology ; Cisplatin/therapeutic use ; Kinetics ; Cell Line, Tumor
Czasopismo naukowe
Szczegóły
Tytuł:
Design and application of prodrug fluorescent probes for the detection of ovarian cancer cells and release of anticancer drug.
Autorzy:
Chen S; College of Science, China Agricultural University, Beijing, 100193, PR China.
Tang Y; College of Science, China Agricultural University, Beijing, 100193, PR China.
Li Y; College of Science, China Agricultural University, Beijing, 100193, PR China.
Huang M; College of Science, China Agricultural University, Beijing, 100193, PR China.
Ma X; College of Science, China Agricultural University, Beijing, 100193, PR China.
Wang L; College of Science, China Agricultural University, Beijing, 100193, PR China.
Wu Y; College of Science, China Agricultural University, Beijing, 100193, PR China.
Wang Y; College of Science, China Agricultural University, Beijing, 100193, PR China.
Fan W; College of Science, China Agricultural University, Beijing, 100193, PR China.
Hou S; College of Science, China Agricultural University, Beijing, 100193, PR China. Electronic address: .
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Źródło:
Biosensors & bioelectronics [Biosens Bioelectron] 2023 Sep 15; Vol. 236, pp. 115401. Date of Electronic Publication: 2023 May 25.
Typ publikacji:
Journal Article
MeSH Terms:
Prodrugs*/pharmacology
Prodrugs*/chemistry
Biosensing Techniques*
Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/chemistry
Ovarian Neoplasms*/diagnosis
Ovarian Neoplasms*/drug therapy
Female ; Humans ; Fluorescent Dyes/chemistry ; beta-Galactosidase
Czasopismo naukowe
Szczegóły
Tytuł:
Platinum based theranostics nanoplatforms for antitumor applications.
Autorzy:
Li H; College of Medical Technology and Engineering, The 1st Affiliated Hospital, Henan University of Science and Technology, Luoyang 471000, China. .
Cheng S; Key Laboratory of Hainan Trauma and Disaster Rescue, The First Affiliated Hospital of Hainan Medical University, College of Emergency and Trauma, Hainan Medical University, Haikou 571199, China.
Zhai J; College of Medical Technology and Engineering, The 1st Affiliated Hospital, Henan University of Science and Technology, Luoyang 471000, China. .
Lei K; College of Medical Technology and Engineering, The 1st Affiliated Hospital, Henan University of Science and Technology, Luoyang 471000, China. .
Zhou P; Key Laboratory of Hainan Trauma and Disaster Rescue, The First Affiliated Hospital of Hainan Medical University, College of Emergency and Trauma, Hainan Medical University, Haikou 571199, China.
Cai K; Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, China. kaiyong_.
Li J; College of Medical Technology and Engineering, The 1st Affiliated Hospital, Henan University of Science and Technology, Luoyang 471000, China. .; Key Laboratory of Hainan Trauma and Disaster Rescue, The First Affiliated Hospital of Hainan Medical University, College of Emergency and Trauma, Hainan Medical University, Haikou 571199, China.; Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, China. kaiyong_.
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Źródło:
Journal of materials chemistry. B [J Mater Chem B] 2023 Sep 13; Vol. 11 (35), pp. 8387-8403. Date of Electronic Publication: 2023 Sep 13.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/therapeutic use
Neoplasms*/diagnostic imaging
Neoplasms*/drug therapy
Photochemotherapy*
Humans ; Platinum ; Precision Medicine
Czasopismo naukowe
Szczegóły
Tytuł:
Homo- and heterometallic complexes of Zn(II), {Zn(II)Au(I)}, and {Zn(II)Ag(I)} with pentadentate Schiff base ligands as promising anticancer agents.
Autorzy:
Zhivkova T; Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Acad. Georgi Bonchev Str., Bl. 25, Sofia 1113, Bulgaria. .
Culita DC; Ilie Murgulescu Institute of Physical Chemistry, Romanian Academy, Splaiul Independentei 202, 060021 Bucharest, Romania. .
Abudalleh A; Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Acad. Georgi Bonchev Str., Bl. 25, Sofia 1113, Bulgaria. .
Dyakova L; Institute of Neurobiology, Bulgarian Academy of Sciences, Acad. Georgi Bonchev Str., Bl. 23, Sofia 1113, Bulgaria.
Mocanu T; Ilie Murgulescu Institute of Physical Chemistry, Romanian Academy, Splaiul Independentei 202, 060021 Bucharest, Romania. .
Madalan AM; Faculty of Chemistry, University of Bucharest, Regina Elisabeta Blvd. 4-12, 030018 Bucharest, Romania.
Georgieva M; Institute of Molecular Biology 'Roumen Tsanev', Acad. Georgi Bonchev Str., Bl. 21, Sofia 1113, Bulgaria.
Miloshev G; Institute of Molecular Biology 'Roumen Tsanev', Acad. Georgi Bonchev Str., Bl. 21, Sofia 1113, Bulgaria.
Hanganu A; Faculty of Chemistry, University of Bucharest, Regina Elisabeta Blvd. 4-12, 030018 Bucharest, Romania.; 'C.D. Nenitzescu' Institute of Organic and Supramolecular Chemistry of the Romanian Academy, Splaiul Independentei 202B, Bucharest, Romania.
Marinescu G; Ilie Murgulescu Institute of Physical Chemistry, Romanian Academy, Splaiul Independentei 202, 060021 Bucharest, Romania. .
Alexandrova R; Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Acad. Georgi Bonchev Str., Bl. 25, Sofia 1113, Bulgaria. .
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Źródło:
Dalton transactions (Cambridge, England : 2003) [Dalton Trans] 2023 Sep 13; Vol. 52 (35), pp. 12282-12295. Date of Electronic Publication: 2023 Sep 13.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/chemistry
Triple Negative Breast Neoplasms*
Humans ; Schiff Bases/pharmacology ; Schiff Bases/chemistry ; Ligands ; Zinc/pharmacology ; Zinc/chemistry ; Pyridines
Czasopismo naukowe
Szczegóły
Tytuł:
Development of a novel sialic acid-conjugated camptothecin prodrug for enhanced cancer chemotherapy.
Autorzy:
Dong H; National Glycoengineering Research Center and Shandong Key Laboratory of Carbohydrate Chemistry and Glycobiology, NMPA Key Laboratory for Quality Research and Evaluation of Carbohydrate-based Medicine, Shandong University, Qingdao, Shandong 266237, China. .
Huang X; Departments of Chemistry and Biomedical Engineering, Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, Michigan 48824, USA.
Wu X; National Glycoengineering Research Center and Shandong Key Laboratory of Carbohydrate Chemistry and Glycobiology, NMPA Key Laboratory for Quality Research and Evaluation of Carbohydrate-based Medicine, Shandong University, Qingdao, Shandong 266237, China. .; Suzhou Research Institute, Shandong University, Suzhou, Jiangsu 215123, China.
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Źródło:
Biomaterials science [Biomater Sci] 2023 Sep 12; Vol. 11 (18), pp. 6160-6166. Date of Electronic Publication: 2023 Sep 12.
Typ publikacji:
Journal Article
MeSH Terms:
Prodrugs*/pharmacology
Prodrugs*/therapeutic use
Nanoparticles*/chemistry
Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/therapeutic use
Antineoplastic Agents*/chemistry
Neoplasms*/drug therapy
Mice ; Animals ; Camptothecin/chemistry ; N-Acetylneuraminic Acid ; Cell Line, Tumor
Czasopismo naukowe
Szczegóły
Tytuł:
Pyrrolidinedione-thiazolidinone hybrid molecules with potent cytotoxic effect in squamous cell carcinoma SCC-15 cells.
Autorzy:
Finiuk N; Department of Regulation of Cell Proliferation and Apoptosis, Institute of Cell Biology of National Academy of Sciences of Ukraine, Drahomanov 14/16, 79005 Lviv, Ukraine. Electronic address: .
Kaleniuk E; Department of Biotechnology and Cell Biology, Medical College, University of Information Technology and Management in Rzeszow, Sucharskiego 2, 35-225 Rzeszow, Poland.
Holota S; Department of Pharmaceutical, Organic and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University, Pekarska 69, 79010 Lviv, Ukraine.
Stoika R; Department of Regulation of Cell Proliferation and Apoptosis, Institute of Cell Biology of National Academy of Sciences of Ukraine, Drahomanov 14/16, 79005 Lviv, Ukraine.
Lesyk R; Department of Biotechnology and Cell Biology, Medical College, University of Information Technology and Management in Rzeszow, Sucharskiego 2, 35-225 Rzeszow, Poland; Department of Pharmaceutical, Organic and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University, Pekarska 69, 79010 Lviv, Ukraine.
Szychowski KA; Department of Biotechnology and Cell Biology, Medical College, University of Information Technology and Management in Rzeszow, Sucharskiego 2, 35-225 Rzeszow, Poland.
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Źródło:
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2023 Sep 07; Vol. 92, pp. 117442. Date of Electronic Publication: 2023 Aug 11.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Carcinoma, Squamous Cell*/drug therapy
Tongue Neoplasms*/drug therapy
Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/therapeutic use
Humans ; Animals ; Mice ; Cell Line, Tumor ; Reactive Oxygen Species/metabolism ; PPAR gamma/pharmacology ; Apoptosis
Czasopismo naukowe
Szczegóły
Tytuł:
Insights about the ability of folate based supramolecular gels to act as targeted therapeutic agents.
Autorzy:
Rizzo C; Università degli Studi di Palermo, Dipartimento STEBICEF, Sezione di Chimica, Viale delle Scienze Ed. 17, 90128 Palermo, Italy. .
Cancemi P; Università degli Studi di Palermo, Dipartimento STEBICEF, Sezione di Biologia Cellulare, Viale delle Scienze Ed. 16, 90128 Palermo, Italy.
Buttacavoli M; Università degli Studi di Palermo, Dipartimento STEBICEF, Sezione di Biologia Cellulare, Viale delle Scienze Ed. 16, 90128 Palermo, Italy.
Di Cara G; Università degli Studi di Palermo, Dipartimento STEBICEF, Sezione di Biologia Cellulare, Viale delle Scienze Ed. 16, 90128 Palermo, Italy.
D'Amico C; Università degli Studi di Palermo, Dipartimento STEBICEF, Sezione di Biologia Cellulare, Viale delle Scienze Ed. 16, 90128 Palermo, Italy.
Billeci F; Università degli Studi di Palermo, Dipartimento STEBICEF, Sezione di Chimica, Viale delle Scienze Ed. 17, 90128 Palermo, Italy. .
Marullo S; Università degli Studi di Palermo, Dipartimento STEBICEF, Sezione di Chimica, Viale delle Scienze Ed. 17, 90128 Palermo, Italy. .
D'Anna F; Università degli Studi di Palermo, Dipartimento STEBICEF, Sezione di Chimica, Viale delle Scienze Ed. 17, 90128 Palermo, Italy. .
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Źródło:
Journal of materials chemistry. B [J Mater Chem B] 2023 Sep 06; Vol. 11 (32), pp. 7721-7738. Date of Electronic Publication: 2023 Sep 06.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Salts*/chemistry
Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/chemistry
Solvents/chemistry ; Cell Line ; Gels/chemistry
Czasopismo naukowe
Szczegóły
Wyświetlanie 1-20 z 339180

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