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Wyszukujesz frazę ""Antineoplastic Agents, Phytogenic"" wg kryterium: Temat


Tytuł :
Berberine-10-hydroxy camptothecine-loaded lipid microsphere for the synergistic treatment of liver cancer by inhibiting topoisomerase and HIF-1α.
Autorzy :
Qi Y; Department of Pharmacy, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, P. R. China.
Liu G; Department of Pharmacy, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, P. R. China.
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Źródło :
Drug delivery [Drug Deliv] 2021 Dec; Vol. 28 (1), pp. 171-182.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Hepatocellular*
Liver Neoplasms*
Microspheres*
Antineoplastic Agents, Phytogenic/*pharmacology
Berberine/*pharmacology
Camptothecin/*analogs & derivatives
Topoisomerase I Inhibitors/*pharmacology
Animals ; Antineoplastic Agents, Phytogenic/administration & dosage ; Antineoplastic Agents, Phytogenic/chemistry ; Berberine/administration & dosage ; Berberine/chemistry ; Camptothecin/administration & dosage ; Camptothecin/chemistry ; Camptothecin/pharmacology ; Cell Line, Tumor ; Drug Delivery Systems ; Drug Liberation ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/antagonists & inhibitors ; Mice ; Mice, Nude ; Rats ; Topoisomerase I Inhibitors/administration & dosage ; Topoisomerase I Inhibitors/chemistry ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Molecular mechanisms underlying chemopreventive potential of butein: Current trends and future perspectives.
Autorzy :
Tuli HS; Department of Biotechnology, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala, Haryana, 133207, India. Electronic address: .
Joshi R; Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM's NMIMS, Mumbai, 56, Maharashtra, India.
Aggarwal D; Department of Biotechnology, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala, Haryana, 133207, India.
Kaur G; Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM's NMIMS, Mumbai, 56, Maharashtra, India.
Kaur J; Graduate School of Biomedical Engineering, ARC Centre of Excellence in Nanoscale Biophotonics (CNBP), Faculty of Engineering, The University of New South Wales, Sydney, 2052, Australia.
Kumar M; Department of Chemistry, Maharishi Markandeshwar University, Sadopur, 134007, Haryana, India.
Parashar NC; Department of Biotechnology, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala, Haryana, 133207, India.
Khan MA; The Research Center for Preclinical Medicine, Southwest Medical University, Luzhou, 646000, China.
Sak K; NGO Praeventio, Tartu, 50407, Estonia. Electronic address: .
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Źródło :
Chemico-biological interactions [Chem Biol Interact] 2021 Dec 01; Vol. 350, pp. 109699. Date of Electronic Publication: 2021 Oct 11.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antineoplastic Agents, Phytogenic/*pharmacology
Chalcones/*pharmacology
Angiogenesis Inhibitors/chemistry ; Angiogenesis Inhibitors/pharmacology ; Animals ; Anti-Inflammatory Agents, Non-Steroidal/chemistry ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Anticarcinogenic Agents/chemistry ; Anticarcinogenic Agents/pharmacology ; Antineoplastic Agents, Phytogenic/chemistry ; Antineoplastic Agents, Phytogenic/pharmacokinetics ; Apoptosis/drug effects ; Cell Cycle Checkpoints/drug effects ; Chalcones/chemistry ; Chalcones/pharmacokinetics ; Chemoprevention ; Drug Delivery Systems ; Drug Screening Assays, Antitumor ; Drug Synergism ; Female ; Humans ; Male ; Nanotechnology ; Oxidation-Reduction
Czasopismo naukowe
Tytuł :
Onopordopicrin from the new genus Shangwua as a novel thioredoxin reductase inhibitor to induce oxidative stress-mediated tumor cell apoptosis.
Autorzy :
Zhang J; School of Pharmacy, State Key Laboratory of Applied Organic Chemistry, and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, China.
Zheng ZQ; School of Pharmacy, State Key Laboratory of Applied Organic Chemistry, and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, China.
Xu Q; School of Pharmacy, State Key Laboratory of Applied Organic Chemistry, and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, China.
Li Y; School of Pharmacy, State Key Laboratory of Applied Organic Chemistry, and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, China.
Gao K; School of Pharmacy, State Key Laboratory of Applied Organic Chemistry, and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, China.
Fang J; School of Pharmacy, State Key Laboratory of Applied Organic Chemistry, and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, China.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 790-801.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents, Phytogenic/*pharmacology
Apoptosis/*drug effects
Asteraceae/*chemistry
Enzyme Inhibitors/*pharmacology
Lactones/*pharmacology
Sesquiterpenes/*pharmacology
Thioredoxin-Disulfide Reductase/*antagonists & inhibitors
Antineoplastic Agents, Phytogenic/chemistry ; Antineoplastic Agents, Phytogenic/isolation & purification ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/isolation & purification ; Humans ; Lactones/chemistry ; Lactones/isolation & purification ; Molecular Docking Simulation ; Molecular Structure ; Oxidative Stress/drug effects ; Sesquiterpenes/chemistry ; Sesquiterpenes/isolation & purification ; Structure-Activity Relationship ; Thioredoxin-Disulfide Reductase/metabolism ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Optimization of trypsin extraction technology of Allium cepa L. polysaccharide by response surface methodology and the antitumor effects through immunomodulation.
Autorzy :
Ji YB; School of Pharmacy, Engineering Research Center for Medicine, Harbin University of Commerce , Harbin, Heilongjiang, P.R. China.; Engineering Research Center of Natural Anticancer Drugs, Ministry of Education , Harbin, Heilongjiang P.R. China.
Wang FL; School of Pharmacy, Engineering Research Center for Medicine, Harbin University of Commerce , Harbin, Heilongjiang, P.R. China.; Engineering Research Center of Natural Anticancer Drugs, Ministry of Education , Harbin, Heilongjiang P.R. China.
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Źródło :
Bioengineered [Bioengineered] 2021 Dec; Vol. 12 (1), pp. 382-391.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents, Phytogenic*/chemistry
Antineoplastic Agents, Phytogenic*/isolation & purification
Antineoplastic Agents, Phytogenic*/pharmacology
Phytochemicals*/chemistry
Phytochemicals*/isolation & purification
Phytochemicals*/pharmacology
Polysaccharides*/chemistry
Polysaccharides*/isolation & purification
Polysaccharides*/pharmacology
Onions/*chemistry
Trypsin/*metabolism
Animals ; Cell Proliferation ; Cytokines/metabolism ; Female ; Immunomodulation ; Male ; Mice ; Neoplasms, Experimental ; Onions/metabolism ; Research Design
Czasopismo naukowe
Tytuł :
Camptothecin's journey from discovery to WHO Essential Medicine: Fifty years of promise.
Autorzy :
Khaiwa N; College of Pharmacy, University of Sharjah, 27272, Sharjah, United Arab Emirates.
Maarouf NR; College of Pharmacy, University of Sharjah, 27272, Sharjah, United Arab Emirates.
Darwish MH; College of Pharmacy, University of Sharjah, 27272, Sharjah, United Arab Emirates.
Alhamad DWM; Sharjah Institute for Medical Research, 27272, Sharjah, United Arab Emirates.
Sebastian A; Sharjah Institute for Medical Research, 27272, Sharjah, United Arab Emirates.
Hamad M; Sharjah Institute for Medical Research, 27272, Sharjah, United Arab Emirates; College of Health Sciences, 27272, Sharjah, United Arab Emirates.
Omar HA; College of Pharmacy, University of Sharjah, 27272, Sharjah, United Arab Emirates; Sharjah Institute for Medical Research, 27272, Sharjah, United Arab Emirates.
Orive G; NanoBioCel Group, Laboratory of Pharmaceutics, School of Pharmacy, University of the Basque Country (UPV/EHU), Paseo de la Universidad 7, 01006, Vitoria-Gasteiz, Spain.
Al-Tel TH; College of Pharmacy, University of Sharjah, 27272, Sharjah, United Arab Emirates; Sharjah Institute for Medical Research, 27272, Sharjah, United Arab Emirates. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Nov 05; Vol. 223, pp. 113639. Date of Electronic Publication: 2021 Jun 17.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antineoplastic Agents, Phytogenic/*chemistry
Camptothecin/*analogs & derivatives
Antineoplastic Agents, Phytogenic/metabolism ; Antineoplastic Agents, Phytogenic/pharmacology ; Antineoplastic Agents, Phytogenic/therapeutic use ; Camptotheca/chemistry ; Camptotheca/metabolism ; Camptothecin/metabolism ; Camptothecin/pharmacology ; Camptothecin/therapeutic use ; Cell Survival/drug effects ; Drug Carriers/chemistry ; Humans ; Neoplasms/drug therapy ; Neoplasms/pathology ; Structure-Activity Relationship ; Topoisomerase I Inhibitors/chemistry ; Topoisomerase I Inhibitors/metabolism ; Topoisomerase I Inhibitors/pharmacology ; Topoisomerase I Inhibitors/therapeutic use ; World Health Organization
Czasopismo naukowe
Tytuł :
Chemical constituents from Artemisia vulgaris and their antiausterity activities against the PANC-1 human pancreatic cancer cell line.
Autorzy :
Omar AM; Division of Natural Drug Discovery, Institute of Natural Medicine, University of Toyama, Toyama, Japan.
Dibwe DF; Division of Natural Drug Discovery, Institute of Natural Medicine, University of Toyama, Toyama, Japan.
Tawila AM; Division of Natural Drug Discovery, Institute of Natural Medicine, University of Toyama, Toyama, Japan.
Sun S; Division of Natural Drug Discovery, Institute of Natural Medicine, University of Toyama, Toyama, Japan.
Kim MJ; Division of Natural Drug Discovery, Institute of Natural Medicine, University of Toyama, Toyama, Japan.
Awale S; Division of Natural Drug Discovery, Institute of Natural Medicine, University of Toyama, Toyama, Japan.
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Źródło :
Natural product research [Nat Prod Res] 2021 Nov; Vol. 35 (22), pp. 4279-4285. Date of Electronic Publication: 2019 Dec 07.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents, Phytogenic*/pharmacology
Antineoplastic Agents, Phytogenic*/therapeutic use
Artemisia*
Pancreatic Neoplasms*/drug therapy
Cell Line, Tumor ; Drug Screening Assays, Antitumor ; Humans ; Molecular Structure
Czasopismo naukowe
Tytuł :
Anticancer effects of root and beet leaf extracts (Beta vulgaris L.) in cervical cancer cells (HeLa).
Autorzy :
Romero SA; Multidisciplinary Laboratory of Food and Health (LabMAS), School of Applied Sciences (FCA), University of Campinas (UNICAMP), Limeira, Brazil.
Pavan ICB; Laboratory of Signal Mechanisms, School of Pharmaceutical Sciences (FCF), University of Campinas (UNICAMP), Campinas, Brazil.
Morelli AP; Multidisciplinary Laboratory of Food and Health (LabMAS), School of Applied Sciences (FCA), University of Campinas (UNICAMP), Limeira, Brazil.
Mancini MCS; Multidisciplinary Laboratory of Food and Health (LabMAS), School of Applied Sciences (FCA), University of Campinas (UNICAMP), Limeira, Brazil.
da Silva LGS; Multidisciplinary Laboratory of Food and Health (LabMAS), School of Applied Sciences (FCA), University of Campinas (UNICAMP), Limeira, Brazil.
Fagundes I; Multidisciplinary Laboratory of Food and Health (LabMAS), School of Applied Sciences (FCA), University of Campinas (UNICAMP), Limeira, Brazil.
Silva CHR; Multidisciplinary Laboratory of Food and Health (LabMAS), School of Applied Sciences (FCA), University of Campinas (UNICAMP), Limeira, Brazil.
Ponte LGS; Multidisciplinary Laboratory of Food and Health (LabMAS), School of Applied Sciences (FCA), University of Campinas (UNICAMP), Limeira, Brazil.
Rostagno MA; Multidisciplinary Laboratory of Food and Health (LabMAS), School of Applied Sciences (FCA), University of Campinas (UNICAMP), Limeira, Brazil.
Bezerra RMN; Multidisciplinary Laboratory of Food and Health (LabMAS), School of Applied Sciences (FCA), University of Campinas (UNICAMP), Limeira, Brazil.
Simabuco FM; Multidisciplinary Laboratory of Food and Health (LabMAS), School of Applied Sciences (FCA), University of Campinas (UNICAMP), Limeira, Brazil.
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Źródło :
Phytotherapy research : PTR [Phytother Res] 2021 Nov; Vol. 35 (11), pp. 6191-6203. Date of Electronic Publication: 2021 Sep 08.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents, Phytogenic*/pharmacology
Antineoplastic Agents, Phytogenic*/therapeutic use
Beta vulgaris*
Uterine Cervical Neoplasms*/drug therapy
Apoptosis ; Cell Proliferation ; HeLa Cells ; Humans ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use
Czasopismo naukowe
Tytuł :
Methyl Jasmonate Effect on Betulinic Acid Content and Biological Properties of Extract from Senna obtusifolia Transgenic Hairy Roots.
Autorzy :
Kowalczyk T; Department of Molecular Biotechnology and Genetics, University of Lodz, Banacha 12/16, 90-237 Lodz, Poland.
Sitarek P; Department of Biology and Pharmaceutical Botany, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland.
Merecz-Sadowska A; Department of Computer Science in Economics, University of Lodz, 90-214 Lodz, Poland.
Szyposzyńska M; CBRN Reconnaissance and Decontamination Department, Military Institute of Chemistry and Radiometry, Antoniego Chrusciela 'Montera' 105, 00-910 Warsaw, Poland.
Spławska A; CBRN Reconnaissance and Decontamination Department, Military Institute of Chemistry and Radiometry, Antoniego Chrusciela 'Montera' 105, 00-910 Warsaw, Poland.
Gorniak L; Biohazard Prevention Centre, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland.
Bijak M; Biohazard Prevention Centre, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland.
Śliwiński T; Department of Medical Biochemistry, Medical University of Lodz, Mazowiecka 6/8, 92-215 Lodz, Poland.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Oct 14; Vol. 26 (20). Date of Electronic Publication: 2021 Oct 14.
Typ publikacji :
Journal Article
MeSH Terms :
Acetates/*pharmacology
Antineoplastic Agents, Phytogenic/*metabolism
Cyclopentanes/*pharmacology
Oxylipins/*pharmacology
Pentacyclic Triterpenes/*metabolism
Senna Plant/*drug effects
Senna Plant/*metabolism
A549 Cells ; Antineoplastic Agents, Phytogenic/biosynthesis ; Antineoplastic Agents, Phytogenic/pharmacology ; Apoptosis/drug effects ; Bioreactors ; Biotechnology ; Cell Line, Tumor ; Cell Survival/drug effects ; DNA Damage ; DNA Fragmentation/drug effects ; Humans ; Membrane Potential, Mitochondrial/drug effects ; Pentacyclic Triterpenes/pharmacology ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Plant Growth Regulators/pharmacology ; Plant Roots/drug effects ; Plant Roots/growth & development ; Plant Roots/metabolism ; Plants, Genetically Modified ; Plants, Medicinal/drug effects ; Plants, Medicinal/growth & development ; Plants, Medicinal/metabolism ; Senna Plant/growth & development
Czasopismo naukowe
Tytuł :
Ent- trachylobane-3 β -hydroperoxide, a new diterpene from the root bark of Chrozophora oblongifolia (Fam.; Euphorbiaceae).
Autorzy :
Kamel MR; Faculty of Pharmacy, Department of Pharmacognosy, Al-Azhar University, Assiut, Egypt.
Nafady AM; Faculty of Pharmacy, Department of Pharmacognosy, Al-Azhar University, Assiut, Egypt.
Hassanein AMM; Faculty of Pharmacy, Department of Pharmacognosy, Al-Azhar University, Assiut, Egypt.
Hassan AR; Department of Medicinal and Aromatic Plants, Desert Research Center, El-Matariya, Egypt.; Department of Agro-Environmental Sciences, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka, Japan.
Shimizu K; Department of Agro-Environmental Sciences, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka, Japan.
Ibrahim RR; Faculty of Pharmacy, Department of Pharmacognosy, Helwan University, Cairo, Egypt.
Haggag EG; Faculty of Pharmacy, Department of Pharmacognosy, Helwan University, Cairo, Egypt.
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Źródło :
Natural product research [Nat Prod Res] 2021 Oct; Vol. 35 (19), pp. 3177-3184. Date of Electronic Publication: 2019 Nov 06.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents, Phytogenic*/isolation & purification
Antineoplastic Agents, Phytogenic*/pharmacology
Diterpenes*/isolation & purification
Diterpenes*/pharmacology
Euphorbiaceae*/chemistry
Humans ; Hydrogen Peroxide ; MCF-7 Cells ; Molecular Structure ; Phytochemicals/isolation & purification ; Phytochemicals/pharmacology ; Plant Bark/chemistry ; Plant Roots/chemistry
Czasopismo naukowe
Tytuł :
Diarylpentanones from the root of Wikstroemia indica and their cytotoxic activity against human lung A549 cells.
Autorzy :
Liu Z; School of Traditional Chinese MateriaMedica, Shenyang Pharmaceutical University, Shenyang, China.; Development and Utilization Key Laboratory of Northeast Plant Materials, Key Laboratory of Northeast Authentic Materials Research and Development in Liaoning Province, School of Traditional Chinese MateriaMedica, Shenyang Pharmaceutical University, Shenyang, China.
Dong M; School of Traditional Chinese MateriaMedica, Shenyang Pharmaceutical University, Shenyang, China.; Development and Utilization Key Laboratory of Northeast Plant Materials, Key Laboratory of Northeast Authentic Materials Research and Development in Liaoning Province, School of Traditional Chinese MateriaMedica, Shenyang Pharmaceutical University, Shenyang, China.
Qiu X; School of Traditional Chinese MateriaMedica, Shenyang Pharmaceutical University, Shenyang, China.; Development and Utilization Key Laboratory of Northeast Plant Materials, Key Laboratory of Northeast Authentic Materials Research and Development in Liaoning Province, School of Traditional Chinese MateriaMedica, Shenyang Pharmaceutical University, Shenyang, China.
Han N; School of Traditional Chinese MateriaMedica, Shenyang Pharmaceutical University, Shenyang, China.; Development and Utilization Key Laboratory of Northeast Plant Materials, Key Laboratory of Northeast Authentic Materials Research and Development in Liaoning Province, School of Traditional Chinese MateriaMedica, Shenyang Pharmaceutical University, Shenyang, China.
Yin J; School of Traditional Chinese MateriaMedica, Shenyang Pharmaceutical University, Shenyang, China.; Development and Utilization Key Laboratory of Northeast Plant Materials, Key Laboratory of Northeast Authentic Materials Research and Development in Liaoning Province, School of Traditional Chinese MateriaMedica, Shenyang Pharmaceutical University, Shenyang, China.
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Źródło :
Natural product research [Nat Prod Res] 2021 Oct; Vol. 35 (19), pp. 3346-3349. Date of Electronic Publication: 2019 Dec 09.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents, Phytogenic*/isolation & purification
Antineoplastic Agents, Phytogenic*/pharmacology
Wikstroemia*/chemistry
Pentanones/*pharmacology
A549 Cells ; Humans ; Magnetic Resonance Spectroscopy ; Molecular Structure ; Pentanones/isolation & purification ; Phytochemicals/isolation & purification ; Phytochemicals/pharmacology ; Plant Roots/chemistry
Czasopismo naukowe
Tytuł :
A new cycloartane triterpene bisdesmoside from the rhizomes of Actaea vaginata .
Autorzy :
Zhang M; College of Medicine, Xi'an International University, Xi'an, P.R. China.; Faculty of Medicine and Health Sciences, University Malaysia Sabah, Kota Kinabalu, Malaysia.
Yang Q; Beijing Key Laboratory of New Drug Discovery based on Classic Chinese Medicine Prescription, Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P.R. China.
Zhang X; College of Medicine, Xi'an International University, Xi'an, P.R. China.; Faculty of Medicine and Health Sciences, University Malaysia Sabah, Kota Kinabalu, Malaysia.
Wu H; Beijing Key Laboratory of New Drug Discovery based on Classic Chinese Medicine Prescription, Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P.R. China.
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Źródło :
Natural product research [Nat Prod Res] 2021 Oct; Vol. 35 (20), pp. 3426-3431. Date of Electronic Publication: 2019 Dec 10.
Typ publikacji :
Journal Article
MeSH Terms :
Actaea*/chemistry
Antineoplastic Agents, Phytogenic/*pharmacology
Rhizome/*chemistry
Saponins/*pharmacology
Triterpenes/*pharmacology
Antineoplastic Agents, Phytogenic/chemistry ; Antineoplastic Agents, Phytogenic/isolation & purification ; Cell Line, Tumor ; Humans ; Saponins/chemistry ; Triterpenes/chemistry ; Triterpenes/isolation & purification
Czasopismo naukowe
Tytuł :
Exploring the mechanism of Cremastra Appendiculata (SUANPANQI) against breast cancer by network pharmacology and molecular docking.
Autorzy :
Zhang L; School of Pharmacy, Xi'an Jiaotong University, Xi'an, 710061, China; Shaanxi Key Laboratory of 'Qiyao' Resources and Anti-tumor Acitivities/Shanxi Plant Extract Engineering Technology Research Center, Xi'an, 710061, China.
Yang K; Department of Orthopaedics, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, China.
Wang M; The Xi'an Children's Hospital, Xi'an Jiaotong University, Xi'an, 710003, China.
Zeng L; Department of Respiratory Medicine, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, China.
Sun E; School of Pharmacy, Xi'an Jiaotong University, Xi'an, 710061, China; Shaanxi Key Laboratory of 'Qiyao' Resources and Anti-tumor Acitivities/Shanxi Plant Extract Engineering Technology Research Center, Xi'an, 710061, China.
Zhang F; School of Pharmacy, Xi'an Jiaotong University, Xi'an, 710061, China; Shaanxi Key Laboratory of 'Qiyao' Resources and Anti-tumor Acitivities/Shanxi Plant Extract Engineering Technology Research Center, Xi'an, 710061, China.
Cao Z; School of Pharmacy, Xi'an Jiaotong University, Xi'an, 710061, China; Shaanxi Key Laboratory of 'Qiyao' Resources and Anti-tumor Acitivities/Shanxi Plant Extract Engineering Technology Research Center, Xi'an, 710061, China.
Zhang X; School of Pharmacy, Xi'an Jiaotong University, Xi'an, 710061, China; Shaanxi Key Laboratory of 'Qiyao' Resources and Anti-tumor Acitivities/Shanxi Plant Extract Engineering Technology Research Center, Xi'an, 710061, China.
Zhang H; School of Pharmacy, Xi'an Jiaotong University, Xi'an, 710061, China; Shaanxi Key Laboratory of 'Qiyao' Resources and Anti-tumor Acitivities/Shanxi Plant Extract Engineering Technology Research Center, Xi'an, 710061, China. Electronic address: .
Guo Z; School of Pharmacy, Xi'an Jiaotong University, Xi'an, 710061, China; Shaanxi Key Laboratory of 'Qiyao' Resources and Anti-tumor Acitivities/Shanxi Plant Extract Engineering Technology Research Center, Xi'an, 710061, China. Electronic address: .
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Źródło :
Computational biology and chemistry [Comput Biol Chem] 2021 Oct; Vol. 94, pp. 107396. Date of Electronic Publication: 2020 Oct 01.
Typ publikacji :
Journal Article
MeSH Terms :
Molecular Docking Simulation*
Antineoplastic Agents, Phytogenic/*therapeutic use
Breast Neoplasms/*drug therapy
Drugs, Chinese Herbal/*therapeutic use
Antineoplastic Agents, Phytogenic/chemistry ; Antineoplastic Agents, Phytogenic/isolation & purification ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/isolation & purification ; Female ; Humans ; Medicine, Chinese Traditional ; Molecular Structure ; Orchidaceae/chemistry
Czasopismo naukowe
Tytuł :
Cytotoxic cardenolides from Calotropis gigantea.
Autorzy :
He YL; State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, People's Republic of China; Research Institute, Lanzhou Jiaotong University, Lanzhou, 730070, People's Republic of China.
Yang HY; State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, People's Republic of China.
Huang PZ; State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, People's Republic of China.
Feng WJ; State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, People's Republic of China.
Gao K; State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, People's Republic of China. Electronic address: .
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Źródło :
Phytochemistry [Phytochemistry] 2021 Dec; Vol. 192, pp. 112951. Date of Electronic Publication: 2021 Sep 24.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents*
Antineoplastic Agents, Phytogenic*/pharmacology
Calotropis*
Cardiac Glycosides*
Cardenolides/pharmacology ; Cell Line, Tumor
Czasopismo naukowe
Tytuł :
Progress in structure, synthesis and biological activity of natural cephalotane diterpenoids.
Autorzy :
Jiang C; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, and School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, PR China.
Xue J; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, and School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, PR China.
Yuan Y; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, and School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, PR China.
Li Y; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, and School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, PR China.
Zhao C; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, and School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, PR China.
Jing Q; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, and School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, PR China.
Zhang X; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, and School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, PR China.
Yang M; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, and School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, PR China.
Han T; Department of Pharmaceutical Engineering, College of Life Science & Technology, Heilongjiang Bayi Agricultural University, 5 Xinfeng Road, Daqing, 163319, PR China.
Bai J; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, and School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, PR China.
Li Z; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, and School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, PR China.
Li D; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, and School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, PR China. Electronic address: .
Hua H; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, and School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, PR China. Electronic address: .
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Źródło :
Phytochemistry [Phytochemistry] 2021 Dec; Vol. 192, pp. 112939. Date of Electronic Publication: 2021 Sep 16.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antineoplastic Agents, Phytogenic*/pharmacology
Biological Products*/pharmacology
Cephalotaxus*
Diterpenes*/pharmacology
Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Combined chemotherapy for triple negative breast cancer treatment by paclitaxel and niclosamide nanocrystals loaded thermosensitive hydrogel.
Autorzy :
Zhao D; Beijing Leadingpharm Medical technology development Co. Ltd, Beijing 100094, China.
Hu C; Department of Pharmaceutics, China Pharmaceutical University, Nanjing 211198, China.
Fu Q; Department of Pharmaceutics, China Pharmaceutical University, Nanjing 211198, China. Electronic address: .
Lv H; Department of Pharmaceutics, China Pharmaceutical University, Nanjing 211198, China. Electronic address: .
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Źródło :
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences [Eur J Pharm Sci] 2021 Dec 01; Vol. 167, pp. 105992. Date of Electronic Publication: 2021 Sep 11.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents, Phytogenic*/therapeutic use
Nanoparticles*
Triple Negative Breast Neoplasms*/drug therapy
Cell Line, Tumor ; Humans ; Hydrogels/therapeutic use ; Niclosamide/therapeutic use ; Paclitaxel/therapeutic use ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Cytotoxic activity of standardized extracts, a fraction, and individual secondary metabolites from fenugreek seeds against SKOV-3, HeLa and MOLT-4 cell lines.
Autorzy :
Stefanowicz-Hajduk J; Department of Biology and Pharmaceutical Botany, Medical University of Gdańsk, Gdańsk, Poland.
Król-Kogus B; Department of Pharmacognosy with Medicinal Plants Garden, Medical University of Gdańsk, Gdańsk, Poland.
Sparzak-Stefanowska B; Department of Pharmacognosy with Medicinal Plants Garden, Medical University of Gdańsk, Gdańsk, Poland.
Kimel K; Department of Pharmacognosy with Medicinal Plants Garden, Medical University of Gdańsk, Gdańsk, Poland.
Ochocka JR; Department of Biology and Pharmaceutical Botany, Medical University of Gdańsk, Gdańsk, Poland.
Krauze-Baranowska M; Department of Pharmacognosy with Medicinal Plants Garden, Medical University of Gdańsk, Gdańsk, Poland.
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Źródło :
Pharmaceutical biology [Pharm Biol] 2021 Dec; Vol. 59 (1), pp. 424-437.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents, Phytogenic/*pharmacology
Plant Extracts/*pharmacology
Trigonella/*chemistry
Antineoplastic Agents, Phytogenic/administration & dosage ; Cell Line, Tumor ; Chromatography, High Pressure Liquid ; Drug Synergism ; Female ; Flavonoids/administration & dosage ; Flavonoids/isolation & purification ; Flavonoids/pharmacology ; HaCaT Cells ; HeLa Cells ; Humans ; Inhibitory Concentration 50 ; Leukemia, Lymphoid/drug therapy ; Membrane Potential, Mitochondrial/drug effects ; Ovarian Neoplasms/drug therapy ; Plant Extracts/administration & dosage ; Reactive Oxygen Species/metabolism ; Saponins/administration & dosage ; Saponins/isolation & purification ; Saponins/pharmacology ; Secondary Metabolism ; Seeds ; Trigonella/metabolism ; Uterine Cervical Neoplasms/drug therapy
Czasopismo naukowe
Tytuł :
A novel redox-responsive ursolic acid polymeric prodrug delivery system for osteosarcoma therapy.
Autorzy :
Fu D; Department of Orthopedics, The First Affiliated Hospital of University of Science and Technology of China, Hefei, China.
Ni Z; Department of Orthopedics, The First Affiliated Hospital of University of Science and Technology of China, Hefei, China.
Wu K; Department of Orthopedics, The First Affiliated Hospital of University of Science and Technology of China, Hefei, China.
Cheng P; Department of Orthopedics, The First Affiliated Hospital of University of Science and Technology of China, Hefei, China.
Ji X; Department of Orthopedics, The First Affiliated Hospital of University of Science and Technology of China, Hefei, China.
Li G; Department of Orthopedics, The First Affiliated Hospital of University of Science and Technology of China, Hefei, China.
Shang X; Department of Orthopedics, The First Affiliated Hospital of University of Science and Technology of China, Hefei, China.
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Źródło :
Drug delivery [Drug Deliv] 2021 Dec; Vol. 28 (1), pp. 195-205.
Typ publikacji :
Journal Article
MeSH Terms :
Prodrugs*
Antineoplastic Agents, Phytogenic/*chemistry
Osteosarcoma/*drug therapy
Polyethylene Glycols/*chemistry
Polymers/*chemistry
Triterpenes/*chemistry
Animals ; Antineoplastic Agents, Phytogenic/administration & dosage ; Bone Neoplasms ; Cell Line, Tumor ; Drug Delivery Systems ; Humans ; Mice ; Micelles ; Oxidation-Reduction ; Polymers/administration & dosage ; Stimuli Responsive Polymers ; Triterpenes/administration & dosage ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Three new diterpenoids from Euphorbia peplus .
Autorzy :
Chen YN; Yunnan University of Traditional Chinese Medicine, Kunming, P. R. China.; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P.R. China.
Lu QY; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P.R. China.
Li DM; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P.R. China.; Yunnan University, Kunming, P.R. China.
Li YY; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P.R. China.; Yunnan University, Kunming, P.R. China.
Pu XX; Yunnan University of Traditional Chinese Medicine, Kunming, P. R. China.; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P.R. China.
Li BT; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P.R. China.
Tang XH; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P.R. China.; Yunnan University, Kunming, P.R. China.
Tang HY; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P.R. China.; Yunnan University, Kunming, P.R. China.
Liu S; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P.R. China.
Yang L; Shanghai Key Laboratory of Plant Functional Genomics and Resources, Plant Science Research Center, Shanghai Chenshan Botanical Garden, Shanghai, P. R. China.
Zhang Y; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P.R. China.
Di YT; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P.R. China.
Fang X; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P.R. China.
Hao XJ; Yunnan University of Traditional Chinese Medicine, Kunming, P. R. China.; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P.R. China.
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Źródło :
Natural product research [Nat Prod Res] 2021 Nov; Vol. 35 (21), pp. 3901-3907. Date of Electronic Publication: 2020 Apr 14.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents, Phytogenic*/pharmacology
Diterpenes*/pharmacology
Euphorbia*
Abietanes ; Humans ; Molecular Structure
Czasopismo naukowe
Tytuł :
Two new pregnane alkaloids from Pachysandra terminalis Sieb. et Zucc.
Autorzy :
Zhang Y; Shaanxi Collaborative Innovation Center of Chinese Medicinal Resource Industrialization, Shaanxi Province Key Laboratory of New Drugs and Chinese, School of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, China.
Li Y; Shaanxi Collaborative Innovation Center of Chinese Medicinal Resource Industrialization, Shaanxi Province Key Laboratory of New Drugs and Chinese, School of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, China.; The College of Life Sciences, Northwest University, Xi'an, China.
Huang S; Shaanxi Collaborative Innovation Center of Chinese Medicinal Resource Industrialization, Shaanxi Province Key Laboratory of New Drugs and Chinese, School of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, China.
Cui Y; Department of Pharmacy, Xi'an Medical University, Xi'an, China.
Zhang H; Shaanxi Collaborative Innovation Center of Chinese Medicinal Resource Industrialization, Shaanxi Province Key Laboratory of New Drugs and Chinese, School of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, China.
Huang W; Shaanxi Collaborative Innovation Center of Chinese Medicinal Resource Industrialization, Shaanxi Province Key Laboratory of New Drugs and Chinese, School of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, China.
Deng C; Shaanxi Collaborative Innovation Center of Chinese Medicinal Resource Industrialization, Shaanxi Province Key Laboratory of New Drugs and Chinese, School of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, China.
Wang W; Shaanxi Collaborative Innovation Center of Chinese Medicinal Resource Industrialization, Shaanxi Province Key Laboratory of New Drugs and Chinese, School of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, China.
Song X; Shaanxi Collaborative Innovation Center of Chinese Medicinal Resource Industrialization, Shaanxi Province Key Laboratory of New Drugs and Chinese, School of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, China.
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Źródło :
Natural product research [Nat Prod Res] 2021 Nov; Vol. 35 (21), pp. 3888-3894. Date of Electronic Publication: 2020 Mar 25.
Typ publikacji :
Journal Article
MeSH Terms :
Alkaloids*/isolation & purification
Alkaloids*/pharmacology
Pachysandra*/chemistry
Antineoplastic Agents, Phytogenic/*pharmacology
Pregnanes/*pharmacology
Antineoplastic Agents, Phytogenic/isolation & purification ; Cell Line, Tumor ; Humans ; Plant Extracts ; Pregnanes/isolation & purification
Czasopismo naukowe
Tytuł :
Bioequivalence assessment of high-capacity polymeric micelle nanoformulation of paclitaxel and Abraxane® in rodent and non-human primate models using a stable isotope tracer assay.
Autorzy :
Hwang D; Center for Nanotechnology in Drug Delivery and Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, NC, 27599, United States.
Vinod N; Center for Nanotechnology in Drug Delivery and Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, NC, 27599, United States; Joint UNC/NC State Department of Biomedical Engineering, University of North Carolina, Chapel Hill, NC, 27599, United States.
Skoczen SL; Nanotechnology Characterization Laboratory, Cancer Research Technology Program, Leidos Biomedical Research, Inc., Frederick National Laboratory, Frederick, MD, 21702, United States.
Ramsey JD; Center for Nanotechnology in Drug Delivery and Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, NC, 27599, United States.
Snapp KS; Nanotechnology Characterization Laboratory, Cancer Research Technology Program, Leidos Biomedical Research, Inc., Frederick National Laboratory, Frederick, MD, 21702, United States.
Montgomery SA; Department of Pathology and Laboratory Medicine, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, United States.
Wang M; Biomedical Research Imaging Center, Department of Radiology, and UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27514, United States.
Lim C; Center for Nanotechnology in Drug Delivery and Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, NC, 27599, United States.
Frank JE; Biomedical Research Imaging Center, Department of Radiology, and UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27514, United States.
Sokolsky-Papkov M; Center for Nanotechnology in Drug Delivery and Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, NC, 27599, United States.
Li Z; Biomedical Research Imaging Center, Department of Radiology, and UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27514, United States.
Yuan H; Biomedical Research Imaging Center, Department of Radiology, and UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27514, United States.
Stern ST; Nanotechnology Characterization Laboratory, Cancer Research Technology Program, Leidos Biomedical Research, Inc., Frederick National Laboratory, Frederick, MD, 21702, United States.
Kabanov AV; Center for Nanotechnology in Drug Delivery and Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, NC, 27599, United States; Laboratory of Chemical Design of Bionanomaterials, Faculty of Chemistry, M. V. Lomonosov Moscow State University, Moscow, 119992, Russia. Electronic address: .
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Źródło :
Biomaterials [Biomaterials] 2021 Nov; Vol. 278, pp. 121140. Date of Electronic Publication: 2021 Oct 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Antineoplastic Agents, Phytogenic*
Paclitaxel*
Albumin-Bound Paclitaxel ; Animals ; Cell Line, Tumor ; Drug Carriers ; Isotopes ; Macaca mulatta ; Micelles ; Rats ; Rodentia ; Therapeutic Equivalency
Czasopismo naukowe

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