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Wyszukujesz frazę ""Antisickling Agents"" wg kryterium: Temat


Tytuł :
Phytomedicines (medicines derived from plants) for sickle cell disease.
Autorzy :
Oniyangi O; Paediatrics Department, National Hospital, Abuja, Nigeria.
Cohall DH; Faculty of Medical Sciences, University of the West Indies, St Michael, Barbados.
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Źródło :
The Cochrane database of systematic reviews [Cochrane Database Syst Rev] 2020 Sep 25; Vol. 9. Cochrane AN: CD004448. Date of Electronic Publication: 2020 Sep 25.
Typ publikacji :
Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Systematic Review
MeSH Terms :
Phytotherapy*/adverse effects
Anemia, Sickle Cell/*drug therapy
Antisickling Agents/*therapeutic use
Plant Extracts/*therapeutic use
Adolescent ; Adult ; Amaranthaceae/chemistry ; Anemia/chemically induced ; Anemia, Sickle Cell/blood ; Antisickling Agents/adverse effects ; Child ; Child, Preschool ; Clinical Trials, Phase II as Topic ; Female ; Humans ; Infant ; Male ; Plant Extracts/adverse effects ; Plant Roots/chemistry ; Randomized Controlled Trials as Topic
Czasopismo naukowe
Tytuł :
Effectiveness and Safety of Hydroxyurea in the Treatment of Sickle Cell Anaemia Children in Jos, North Central Nigeria.
Autorzy :
Ofakunrin AOD; Department of Paediatrics, College of Health Sciences, University of Jos/Jos University Teaching Hospital, Jos, Nigeria.
Oguche S; Department of Paediatrics, College of Health Sciences, University of Jos/Jos University Teaching Hospital, Jos, Nigeria.
Adekola K; Division of Hematology-Oncology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA.
Okpe ES; Department of Paediatrics, College of Health Sciences, University of Jos/Jos University Teaching Hospital, Jos, Nigeria.
Afolaranmi TO; Department of Community Medicine, College of Health Sciences, University of Jos/Jos University Teaching Hospital, Jos, Nigeria.
Diaku-Akinwumi IN; Department of Paediatrics, Lagos State University Teaching Hospital, Lagos, Nigeria.
Zoakah AI; Department of Community Medicine, College of Health Sciences, University of Jos/Jos University Teaching Hospital, Jos, Nigeria.
Sagay AS; Department of Obstetrics and Gynaecology, College of Health Sciences, University of Jos/Jos University Teaching Hospital, Jos, Nigeria.
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Źródło :
Journal of tropical pediatrics [J Trop Pediatr] 2020 Jun 01; Vol. 66 (3), pp. 290-298.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Anemia, Sickle Cell/*drug therapy
Antisickling Agents/*therapeutic use
Hydroxyurea/*therapeutic use
Adolescent ; Anemia, Sickle Cell/complications ; Anemia, Sickle Cell/epidemiology ; Antisickling Agents/administration & dosage ; Antisickling Agents/adverse effects ; Child ; Child, Preschool ; Female ; Hematocrit ; Humans ; Hydroxyurea/administration & dosage ; Hydroxyurea/adverse effects ; Infant ; Male ; Nigeria/epidemiology ; Stroke/etiology ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Hydroxyurea Dose Escalation for Sickle Cell Anemia in Sub-Saharan Africa.
Autorzy :
John CC; From the Ryan White Center for Pediatric Infectious Diseases and Global Health, Department of Pediatrics, Indiana University, Indianapolis (C.C.J.); the Department of Pediatrics and Child Health, Makerere University (R.O.O., H.A.H., C.N., P.K., C.M.N.), Global Health Uganda (R.O.O., C.N.), and Mulago Hospital (P.K.) - all in Kampala, Uganda; the Division of Hematology, Department of Pediatrics (T.S.L., A.L., R.E.W.), and the Global Health Center (R.E.W.), Cincinnati Children's Hospital Medical Center, and the University of Cincinnati College of Medicine (A.L., R.E.W.) - all in Cincinnati; and the Department of Pediatrics, Centre Hospitalier Universitaire Sainte-Justine, University of Montreal, Montreal (H.A.H.).
Opoka RO; From the Ryan White Center for Pediatric Infectious Diseases and Global Health, Department of Pediatrics, Indiana University, Indianapolis (C.C.J.); the Department of Pediatrics and Child Health, Makerere University (R.O.O., H.A.H., C.N., P.K., C.M.N.), Global Health Uganda (R.O.O., C.N.), and Mulago Hospital (P.K.) - all in Kampala, Uganda; the Division of Hematology, Department of Pediatrics (T.S.L., A.L., R.E.W.), and the Global Health Center (R.E.W.), Cincinnati Children's Hospital Medical Center, and the University of Cincinnati College of Medicine (A.L., R.E.W.) - all in Cincinnati; and the Department of Pediatrics, Centre Hospitalier Universitaire Sainte-Justine, University of Montreal, Montreal (H.A.H.).
Latham TS; From the Ryan White Center for Pediatric Infectious Diseases and Global Health, Department of Pediatrics, Indiana University, Indianapolis (C.C.J.); the Department of Pediatrics and Child Health, Makerere University (R.O.O., H.A.H., C.N., P.K., C.M.N.), Global Health Uganda (R.O.O., C.N.), and Mulago Hospital (P.K.) - all in Kampala, Uganda; the Division of Hematology, Department of Pediatrics (T.S.L., A.L., R.E.W.), and the Global Health Center (R.E.W.), Cincinnati Children's Hospital Medical Center, and the University of Cincinnati College of Medicine (A.L., R.E.W.) - all in Cincinnati; and the Department of Pediatrics, Centre Hospitalier Universitaire Sainte-Justine, University of Montreal, Montreal (H.A.H.).
Hume HA; From the Ryan White Center for Pediatric Infectious Diseases and Global Health, Department of Pediatrics, Indiana University, Indianapolis (C.C.J.); the Department of Pediatrics and Child Health, Makerere University (R.O.O., H.A.H., C.N., P.K., C.M.N.), Global Health Uganda (R.O.O., C.N.), and Mulago Hospital (P.K.) - all in Kampala, Uganda; the Division of Hematology, Department of Pediatrics (T.S.L., A.L., R.E.W.), and the Global Health Center (R.E.W.), Cincinnati Children's Hospital Medical Center, and the University of Cincinnati College of Medicine (A.L., R.E.W.) - all in Cincinnati; and the Department of Pediatrics, Centre Hospitalier Universitaire Sainte-Justine, University of Montreal, Montreal (H.A.H.).
Nabaggala C; From the Ryan White Center for Pediatric Infectious Diseases and Global Health, Department of Pediatrics, Indiana University, Indianapolis (C.C.J.); the Department of Pediatrics and Child Health, Makerere University (R.O.O., H.A.H., C.N., P.K., C.M.N.), Global Health Uganda (R.O.O., C.N.), and Mulago Hospital (P.K.) - all in Kampala, Uganda; the Division of Hematology, Department of Pediatrics (T.S.L., A.L., R.E.W.), and the Global Health Center (R.E.W.), Cincinnati Children's Hospital Medical Center, and the University of Cincinnati College of Medicine (A.L., R.E.W.) - all in Cincinnati; and the Department of Pediatrics, Centre Hospitalier Universitaire Sainte-Justine, University of Montreal, Montreal (H.A.H.).
Kasirye P; From the Ryan White Center for Pediatric Infectious Diseases and Global Health, Department of Pediatrics, Indiana University, Indianapolis (C.C.J.); the Department of Pediatrics and Child Health, Makerere University (R.O.O., H.A.H., C.N., P.K., C.M.N.), Global Health Uganda (R.O.O., C.N.), and Mulago Hospital (P.K.) - all in Kampala, Uganda; the Division of Hematology, Department of Pediatrics (T.S.L., A.L., R.E.W.), and the Global Health Center (R.E.W.), Cincinnati Children's Hospital Medical Center, and the University of Cincinnati College of Medicine (A.L., R.E.W.) - all in Cincinnati; and the Department of Pediatrics, Centre Hospitalier Universitaire Sainte-Justine, University of Montreal, Montreal (H.A.H.).
Ndugwa CM; From the Ryan White Center for Pediatric Infectious Diseases and Global Health, Department of Pediatrics, Indiana University, Indianapolis (C.C.J.); the Department of Pediatrics and Child Health, Makerere University (R.O.O., H.A.H., C.N., P.K., C.M.N.), Global Health Uganda (R.O.O., C.N.), and Mulago Hospital (P.K.) - all in Kampala, Uganda; the Division of Hematology, Department of Pediatrics (T.S.L., A.L., R.E.W.), and the Global Health Center (R.E.W.), Cincinnati Children's Hospital Medical Center, and the University of Cincinnati College of Medicine (A.L., R.E.W.) - all in Cincinnati; and the Department of Pediatrics, Centre Hospitalier Universitaire Sainte-Justine, University of Montreal, Montreal (H.A.H.).
Lane A; From the Ryan White Center for Pediatric Infectious Diseases and Global Health, Department of Pediatrics, Indiana University, Indianapolis (C.C.J.); the Department of Pediatrics and Child Health, Makerere University (R.O.O., H.A.H., C.N., P.K., C.M.N.), Global Health Uganda (R.O.O., C.N.), and Mulago Hospital (P.K.) - all in Kampala, Uganda; the Division of Hematology, Department of Pediatrics (T.S.L., A.L., R.E.W.), and the Global Health Center (R.E.W.), Cincinnati Children's Hospital Medical Center, and the University of Cincinnati College of Medicine (A.L., R.E.W.) - all in Cincinnati; and the Department of Pediatrics, Centre Hospitalier Universitaire Sainte-Justine, University of Montreal, Montreal (H.A.H.).
Ware RE; From the Ryan White Center for Pediatric Infectious Diseases and Global Health, Department of Pediatrics, Indiana University, Indianapolis (C.C.J.); the Department of Pediatrics and Child Health, Makerere University (R.O.O., H.A.H., C.N., P.K., C.M.N.), Global Health Uganda (R.O.O., C.N.), and Mulago Hospital (P.K.) - all in Kampala, Uganda; the Division of Hematology, Department of Pediatrics (T.S.L., A.L., R.E.W.), and the Global Health Center (R.E.W.), Cincinnati Children's Hospital Medical Center, and the University of Cincinnati College of Medicine (A.L., R.E.W.) - all in Cincinnati; and the Department of Pediatrics, Centre Hospitalier Universitaire Sainte-Justine, University of Montreal, Montreal (H.A.H.).
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Źródło :
The New England journal of medicine [N Engl J Med] 2020 Jun 25; Vol. 382 (26), pp. 2524-2533.
Typ publikacji :
Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Anemia, Sickle Cell/*drug therapy
Antisickling Agents/*administration & dosage
Hydroxyurea/*administration & dosage
Anemia, Sickle Cell/complications ; Antisickling Agents/adverse effects ; Child, Preschool ; Dose-Response Relationship, Drug ; Double-Blind Method ; Female ; Humans ; Hydroxyurea/adverse effects ; Incidence ; Malaria/epidemiology ; Male ; Peripheral Vascular Diseases/etiology ; Peripheral Vascular Diseases/prevention & control ; Prospective Studies ; Uganda
Czasopismo naukowe
Tytuł :
Interventions for preventing silent cerebral infarcts in people with sickle cell disease.
Autorzy :
Estcourt LJ; NHS Blood and Transplant, Haematology/Transfusion Medicine, Level 2, John Radcliffe Hospital, Headington, Oxford, UK, OX3 9BQ.
Kimber C; Systematic Review Initiative, NHS Blood and Transplant, Oxford, UK.
Hopewell S; University of Oxford, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS), Botnar Research Centre, Windmill Road, Oxford, Oxfordshire, UK, OX3 7LD.
Trivella M; University of Oxford, Centre for Statistics in Medicine, Botnar Research Centre, Windmill Road, Oxford, UK, OX3 7LD.
Doree C; NHS Blood and Transplant, Systematic Review Initiative, John Radcliffe Hospital, Oxford, UK, OX3 9BQ.
Abboud MR; American University of Beirut Medical Center, Department of Pediatrics and Adolescent Medicine, Beirut, Lebanon.
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Źródło :
The Cochrane database of systematic reviews [Cochrane Database Syst Rev] 2020 Apr 06; Vol. 4. Cochrane AN: CD012389. Date of Electronic Publication: 2020 Apr 06.
Typ publikacji :
Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Systematic Review
MeSH Terms :
Erythrocyte Transfusion*
Phlebotomy*/adverse effects
Anemia, Sickle Cell/*complications
Antisickling Agents/*therapeutic use
Brain Infarction/*prevention & control
Hydroxyurea/*therapeutic use
Adolescent ; Anemia, Sickle Cell/drug therapy ; Antisickling Agents/adverse effects ; Brain Infarction/etiology ; Cause of Death ; Child ; Cognition/physiology ; Humans ; Hydroxyurea/adverse effects ; Primary Prevention/methods ; Quality of Life ; Randomized Controlled Trials as Topic ; Secondary Prevention/methods ; Stroke/prevention & control
Czasopismo naukowe
Tytuł :
Rational Drug Design of Peptide-Based Therapies for Sickle Cell Disease.
Autorzy :
Olubiyi OO; Institute of Complex Systems: Structural Biochemistry, Forschungszentrum Jülich, 52425 Jülich, Germany.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife 220282, Nigeria.
Olagunju MO; Institute of Complex Systems: Structural Biochemistry, Forschungszentrum Jülich, 52425 Jülich, Germany.
Strodel B; Institute of Complex Systems: Structural Biochemistry, Forschungszentrum Jülich, 52425 Jülich, Germany.; Institute of Theoretical and Computational Chemistry, Heinrich Heine University Düsseldorf, Universitätsstraße 1, 40225 Düsseldorf, Germany.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2019 Dec 12; Vol. 24 (24). Date of Electronic Publication: 2019 Dec 12.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antisickling Agents*/chemistry
Antisickling Agents*/therapeutic use
Drug Design*
Peptides*/chemistry
Peptides*/therapeutic use
Anemia, Sickle Cell/*drug therapy
Anemia, Sickle Cell/metabolism ; Anemia, Sickle Cell/pathology ; Hemoglobin, Sickle/metabolism ; Humans
Czasopismo naukowe
Tytuł :
Tackling adherence in sickle cell disease with mHealth.
Autorzy :
Hankins JS; Department of Hematology, St Jude Children's Research Hospital, Memphis, TN, USA. Electronic address: .
Shah N; Department of Pediatrics, Duke University, Durham, NC, USA.
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Źródło :
The Lancet. Haematology [Lancet Haematol] 2020 Oct; Vol. 7 (10), pp. e713-e714.
Typ publikacji :
Journal Article
MeSH Terms :
Mobile Applications*
Patient Compliance*
Telemedicine*
Anemia, Sickle Cell/*drug therapy
Antisickling Agents/*therapeutic use
Hydroxyurea/*therapeutic use
Humans ; Smartphone
Czasopismo naukowe
Tytuł :
Robust clinical and laboratory response to hydroxyurea using pharmacokinetically guided dosing for young children with sickle cell anemia.
Autorzy :
McGann PT; Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Niss O; Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Dong M; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.; Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Marahatta A; Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Howard TA; Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Mizuno T; Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Lane A; Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Kalfa TA; Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Malik P; Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Quinn CT; Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Ware RE; Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Vinks AA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.; Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
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Źródło :
American journal of hematology [Am J Hematol] 2019 Aug; Vol. 94 (8), pp. 871-879. Date of Electronic Publication: 2019 Jun 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Models, Biological*
Anemia, Sickle Cell/*drug therapy
Antisickling Agents/*administration & dosage
Antisickling Agents/*blood
Hydroxyurea/*administration & dosage
Adolescent ; Anemia, Sickle Cell/blood ; Antisickling Agents/therapeutic use ; Area Under Curve ; Child ; Child, Preschool ; Dose-Response Relationship, Drug ; Drug Monitoring ; Female ; Humans ; Hydroxyurea/blood ; Hydroxyurea/therapeutic use ; Infant ; Male ; Maximum Tolerated Dose ; Practice Guidelines as Topic ; Prospective Studies ; Young Adult
Czasopismo naukowe
Tytuł :
Blood transfusion for preventing primary and secondary stroke in people with sickle cell disease.
Autorzy :
Estcourt LJ; Haematology/Transfusion Medicine, NHS Blood and Transplant, Oxford, UK.
Kohli R; Haematology, Wolfson Institute of Preventive Medicine, London, UK.
Hopewell S; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS), University of Oxford, Oxford, UK.
Trivella M; Centre for Statistics in Medicine, University of Oxford, Oxford, UK.
Wang WC; Department of Hematology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
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Źródło :
The Cochrane database of systematic reviews [Cochrane Database Syst Rev] 2020 Jul 27; Vol. 7. Cochrane AN: CD003146. Date of Electronic Publication: 2020 Jul 27.
Typ publikacji :
Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Systematic Review
MeSH Terms :
Erythrocyte Transfusion*/adverse effects
Primary Prevention*
Secondary Prevention*
Anemia, Sickle Cell/*complications
Stroke/*prevention & control
Adolescent ; Anemia, Sickle Cell/blood ; Antisickling Agents/adverse effects ; Antisickling Agents/therapeutic use ; Blood Transfusion ; Child ; Child, Preschool ; Early Termination of Clinical Trials ; Hemoglobin, Sickle ; Humans ; Hydroxyurea/adverse effects ; Hydroxyurea/therapeutic use ; Iron Chelating Agents/therapeutic use ; Phlebotomy/adverse effects ; Stroke/etiology ; Young Adult
Czasopismo naukowe
Tytuł :
Pharmacokinetics and pharmacodynamics of voxelotor (GBT440) in healthy adults and patients with sickle cell disease.
Autorzy :
Hutchaleelaha A; Global Blood Therapeutics, South San Francisco, CA, USA.
Patel M; Global Blood Therapeutics, South San Francisco, CA, USA.
Washington C; Global Blood Therapeutics, South San Francisco, CA, USA.
Siu V; Global Blood Therapeutics, South San Francisco, CA, USA.
Allen E; IQVIA, Reading, Guy's and St. Thomas' NHS Foundation Trust and King's College, London, UK.
Oksenberg D; Global Blood Therapeutics, South San Francisco, CA, USA.
Gretler DD; Independent Drug Development Consultant, San Francisco, CA, USA.
Mant T; IQVIA, Reading, Guy's and St. Thomas' NHS Foundation Trust and King's College, London, UK.
Lehrer-Graiwer J; Global Blood Therapeutics, South San Francisco, CA, USA.
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Źródło :
British journal of clinical pharmacology [Br J Clin Pharmacol] 2019 Jun; Vol. 85 (6), pp. 1290-1302. Date of Electronic Publication: 2019 Mar 31.
Typ publikacji :
Clinical Trial, Phase I; Clinical Trial, Phase II; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Anemia, Sickle Cell/*drug therapy
Antisickling Agents/*pharmacokinetics
Benzaldehydes/*pharmacokinetics
Pyrazines/*pharmacokinetics
Pyrazoles/*pharmacokinetics
Adolescent ; Adult ; Anemia, Sickle Cell/blood ; Anemia, Sickle Cell/diagnosis ; Antisickling Agents/administration & dosage ; Antisickling Agents/adverse effects ; Benzaldehydes/administration & dosage ; Benzaldehydes/adverse effects ; Biomarkers/blood ; Double-Blind Method ; Erythrocytes/drug effects ; Erythrocytes/metabolism ; Female ; Humans ; London ; Male ; Middle Aged ; Models, Biological ; Oxyhemoglobins/metabolism ; Pyrazines/administration & dosage ; Pyrazines/adverse effects ; Pyrazoles/administration & dosage ; Pyrazoles/adverse effects ; San Francisco ; Treatment Outcome ; Young Adult
Czasopismo naukowe
Tytuł :
Barriers to the use of hydroxyurea in the management of sickle cell disease in Nigeria.
Autorzy :
Adeyemo TA; Department of Haematology and Blood Transfusion, College of Medicine, University of Lagos , Lagos , Nigeria.; Department of Haematology and Blood Transfusion, Lagos University Teaching Hospital , Id-Aarba , Lagos , Nigeria.
Diaku-Akinwunmi IN; Department of Paediatrics, Lagos State College of Medicine , Ikeja , Lagos , Nigeria.
Ojewunmi OO; DNA Laboratory, Sickle Cell Foundation Nigeria , Lagos , Nigeria.
Bolarinwa AB; Department of Haematology and Blood Transfusion, Lagos University Teaching Hospital , Id-Aarba , Lagos , Nigeria.
Adekile AD; Department of Paediatrics, Faculty of Medicine, Kuwait University , Kuwait City , Kuwait.
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Źródło :
Hemoglobin [Hemoglobin] 2019 May; Vol. 43 (3), pp. 188-192. Date of Electronic Publication: 2019 Aug 29.
Typ publikacji :
Journal Article
MeSH Terms :
Anemia, Sickle Cell/*drug therapy
Anemia, Sickle Cell/*epidemiology
Antisickling Agents/*therapeutic use
Hydroxyurea/*therapeutic use
Anemia, Sickle Cell/blood ; Anemia, Sickle Cell/diagnosis ; Antisickling Agents/administration & dosage ; Antisickling Agents/adverse effects ; Cross-Sectional Studies ; Disease Management ; Health Care Surveys ; Health Knowledge, Attitudes, Practice ; Humans ; Hydroxyurea/administration & dosage ; Hydroxyurea/adverse effects ; Nigeria ; Practice Guidelines as Topic ; Quality of Life ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Hydroxyurea Exposure in Lactation: a Pharmacokinetics Study (HELPS).
Autorzy :
Ware RE; Division of Hematology, Cincinnati Children's Hospital, Cincinnati, OH; Global Health Center, Cincinnati Children's Hospital, Cincinnati, OH; University of Cincinnati College of Medicine, Cincinnati, OH. Electronic address: .
Marahatta A; Division of Hematology, Cincinnati Children's Hospital, Cincinnati, OH.
Ware JL; Center for Breastfeeding Medicine, Cincinnati Children's Hospital, Cincinnati, OH.
McElhinney K; Division of Hematology, Cincinnati Children's Hospital, Cincinnati, OH.
Dong M; University of Cincinnati College of Medicine, Cincinnati, OH; Division of Clinical Pharmacology, Cincinnati Children's Hospital, Cincinnati, OH.
Vinks AA; University of Cincinnati College of Medicine, Cincinnati, OH; Division of Clinical Pharmacology, Cincinnati Children's Hospital, Cincinnati, OH.
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Źródło :
The Journal of pediatrics [J Pediatr] 2020 Jul; Vol. 222, pp. 236-239. Date of Electronic Publication: 2020 Mar 11.
Typ publikacji :
Case Reports; Research Support, Non-U.S. Gov't
MeSH Terms :
Anemia, Sickle Cell/*drug therapy
Hydroxyurea/*pharmacokinetics
Lactation/*drug effects
Milk, Human/*metabolism
Adult ; Anemia, Sickle Cell/metabolism ; Antineoplastic Agents/pharmacokinetics ; Antisickling Agents ; Female ; Humans ; Milk, Human/drug effects
Raport
Tytuł :
Interactions of an Anti-Sickling Drug with Hemoglobin in Red Blood Cells from a Patient with Sickle Cell Anemia.
Autorzy :
Strader MB; Laboratory of Biochemistry and Vascular Biology, Center for Biologics Evaluation and Research , Food and Drug Administration (FDA) , Silver Spring , Maryland 20993 , United States.
Liang H; Laboratory of Biochemistry and Vascular Biology, Center for Biologics Evaluation and Research , Food and Drug Administration (FDA) , Silver Spring , Maryland 20993 , United States.
Meng F; Laboratory of Biochemistry and Vascular Biology, Center for Biologics Evaluation and Research , Food and Drug Administration (FDA) , Silver Spring , Maryland 20993 , United States.
Harper J; Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Disease , National Institutes of Health , Bethesda , Maryland 20892-0520 , United States.
Ostrowski DA; Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Disease , National Institutes of Health , Bethesda , Maryland 20892-0520 , United States.
Henry ER; Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Disease , National Institutes of Health , Bethesda , Maryland 20892-0520 , United States.
Shet AS; Sickle Cell Branch, National Heart Lung and Blood Institute , National Institutes of Health , Bethesda , Maryland 20892 , United States.
Eaton WA; Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Disease , National Institutes of Health , Bethesda , Maryland 20892-0520 , United States.
Thein SL; Sickle Cell Branch, National Heart Lung and Blood Institute , National Institutes of Health , Bethesda , Maryland 20892 , United States.
Alayash AI; Laboratory of Biochemistry and Vascular Biology, Center for Biologics Evaluation and Research , Food and Drug Administration (FDA) , Silver Spring , Maryland 20993 , United States.
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Źródło :
Bioconjugate chemistry [Bioconjug Chem] 2019 Mar 20; Vol. 30 (3), pp. 568-571. Date of Electronic Publication: 2019 Feb 28.
Typ publikacji :
Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Anemia, Sickle Cell/*drug therapy
Antisickling Agents/*pharmacology
Benzaldehydes/*pharmacology
Hemoglobin, Sickle/*metabolism
Pyrazines/*pharmacology
Pyrazoles/*pharmacology
Anemia, Sickle Cell/metabolism ; Anemia, Sickle Cell/pathology ; Antisickling Agents/therapeutic use ; Benzaldehydes/therapeutic use ; Erythrocytes/drug effects ; Erythrocytes/metabolism ; Erythrocytes/pathology ; Hemoglobin, Sickle/chemistry ; Humans ; Molecular Docking Simulation ; Oxygen/metabolism ; Pyrazines/therapeutic use ; Pyrazoles/therapeutic use
Czasopismo naukowe
Tytuł :
Hydroxyurea for Children with Sickle Cell Anemia in Sub-Saharan Africa.
Autorzy :
Tshilolo L; From Centre Hospitalier Monkole, Kinshasa, Democratic Republic of Congo (L.T.); the Department of Medicine, University Health Network and Mt. Sinai Hospital, and the University of Toronto, Toronto (G.T.); the Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Program, Kilifi, Kenya (T.N.W.); the Department of Medicine, Imperial College London, London (T.N.W.); Hospital Pediátrico David Bernardino, Luanda, Angola (B.S.); Mbale Clinical Research Institute and Mbale Regional Referral and Teaching Hospital-Busitema University, Mbale, Uganda (P.O.-O.); the Division of Hematology, Department of Pediatrics, Cincinnati Children's Hospital (A.L., S.E.S., T.S.L., P.T.M., R.E.W.), University of Cincinnati College of Medicine (A.L., P.T.M., R.E.W.), and the Global Health Center, Cincinnati Children's Hospital Medical Center (S.E.S., P.T.M., R.E.W.), Cincinnati; and Cohen Children's Medical Center, New Hyde Park, and the Zucker School of Medicine at Hofstra/Northwell, Hempstead - both in New York (B.A.).
Tomlinson G; From Centre Hospitalier Monkole, Kinshasa, Democratic Republic of Congo (L.T.); the Department of Medicine, University Health Network and Mt. Sinai Hospital, and the University of Toronto, Toronto (G.T.); the Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Program, Kilifi, Kenya (T.N.W.); the Department of Medicine, Imperial College London, London (T.N.W.); Hospital Pediátrico David Bernardino, Luanda, Angola (B.S.); Mbale Clinical Research Institute and Mbale Regional Referral and Teaching Hospital-Busitema University, Mbale, Uganda (P.O.-O.); the Division of Hematology, Department of Pediatrics, Cincinnati Children's Hospital (A.L., S.E.S., T.S.L., P.T.M., R.E.W.), University of Cincinnati College of Medicine (A.L., P.T.M., R.E.W.), and the Global Health Center, Cincinnati Children's Hospital Medical Center (S.E.S., P.T.M., R.E.W.), Cincinnati; and Cohen Children's Medical Center, New Hyde Park, and the Zucker School of Medicine at Hofstra/Northwell, Hempstead - both in New York (B.A.).
Williams TN; From Centre Hospitalier Monkole, Kinshasa, Democratic Republic of Congo (L.T.); the Department of Medicine, University Health Network and Mt. Sinai Hospital, and the University of Toronto, Toronto (G.T.); the Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Program, Kilifi, Kenya (T.N.W.); the Department of Medicine, Imperial College London, London (T.N.W.); Hospital Pediátrico David Bernardino, Luanda, Angola (B.S.); Mbale Clinical Research Institute and Mbale Regional Referral and Teaching Hospital-Busitema University, Mbale, Uganda (P.O.-O.); the Division of Hematology, Department of Pediatrics, Cincinnati Children's Hospital (A.L., S.E.S., T.S.L., P.T.M., R.E.W.), University of Cincinnati College of Medicine (A.L., P.T.M., R.E.W.), and the Global Health Center, Cincinnati Children's Hospital Medical Center (S.E.S., P.T.M., R.E.W.), Cincinnati; and Cohen Children's Medical Center, New Hyde Park, and the Zucker School of Medicine at Hofstra/Northwell, Hempstead - both in New York (B.A.).
Santos B; From Centre Hospitalier Monkole, Kinshasa, Democratic Republic of Congo (L.T.); the Department of Medicine, University Health Network and Mt. Sinai Hospital, and the University of Toronto, Toronto (G.T.); the Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Program, Kilifi, Kenya (T.N.W.); the Department of Medicine, Imperial College London, London (T.N.W.); Hospital Pediátrico David Bernardino, Luanda, Angola (B.S.); Mbale Clinical Research Institute and Mbale Regional Referral and Teaching Hospital-Busitema University, Mbale, Uganda (P.O.-O.); the Division of Hematology, Department of Pediatrics, Cincinnati Children's Hospital (A.L., S.E.S., T.S.L., P.T.M., R.E.W.), University of Cincinnati College of Medicine (A.L., P.T.M., R.E.W.), and the Global Health Center, Cincinnati Children's Hospital Medical Center (S.E.S., P.T.M., R.E.W.), Cincinnati; and Cohen Children's Medical Center, New Hyde Park, and the Zucker School of Medicine at Hofstra/Northwell, Hempstead - both in New York (B.A.).
Olupot-Olupot P; From Centre Hospitalier Monkole, Kinshasa, Democratic Republic of Congo (L.T.); the Department of Medicine, University Health Network and Mt. Sinai Hospital, and the University of Toronto, Toronto (G.T.); the Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Program, Kilifi, Kenya (T.N.W.); the Department of Medicine, Imperial College London, London (T.N.W.); Hospital Pediátrico David Bernardino, Luanda, Angola (B.S.); Mbale Clinical Research Institute and Mbale Regional Referral and Teaching Hospital-Busitema University, Mbale, Uganda (P.O.-O.); the Division of Hematology, Department of Pediatrics, Cincinnati Children's Hospital (A.L., S.E.S., T.S.L., P.T.M., R.E.W.), University of Cincinnati College of Medicine (A.L., P.T.M., R.E.W.), and the Global Health Center, Cincinnati Children's Hospital Medical Center (S.E.S., P.T.M., R.E.W.), Cincinnati; and Cohen Children's Medical Center, New Hyde Park, and the Zucker School of Medicine at Hofstra/Northwell, Hempstead - both in New York (B.A.).
Lane A; From Centre Hospitalier Monkole, Kinshasa, Democratic Republic of Congo (L.T.); the Department of Medicine, University Health Network and Mt. Sinai Hospital, and the University of Toronto, Toronto (G.T.); the Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Program, Kilifi, Kenya (T.N.W.); the Department of Medicine, Imperial College London, London (T.N.W.); Hospital Pediátrico David Bernardino, Luanda, Angola (B.S.); Mbale Clinical Research Institute and Mbale Regional Referral and Teaching Hospital-Busitema University, Mbale, Uganda (P.O.-O.); the Division of Hematology, Department of Pediatrics, Cincinnati Children's Hospital (A.L., S.E.S., T.S.L., P.T.M., R.E.W.), University of Cincinnati College of Medicine (A.L., P.T.M., R.E.W.), and the Global Health Center, Cincinnati Children's Hospital Medical Center (S.E.S., P.T.M., R.E.W.), Cincinnati; and Cohen Children's Medical Center, New Hyde Park, and the Zucker School of Medicine at Hofstra/Northwell, Hempstead - both in New York (B.A.).
Aygun B; From Centre Hospitalier Monkole, Kinshasa, Democratic Republic of Congo (L.T.); the Department of Medicine, University Health Network and Mt. Sinai Hospital, and the University of Toronto, Toronto (G.T.); the Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Program, Kilifi, Kenya (T.N.W.); the Department of Medicine, Imperial College London, London (T.N.W.); Hospital Pediátrico David Bernardino, Luanda, Angola (B.S.); Mbale Clinical Research Institute and Mbale Regional Referral and Teaching Hospital-Busitema University, Mbale, Uganda (P.O.-O.); the Division of Hematology, Department of Pediatrics, Cincinnati Children's Hospital (A.L., S.E.S., T.S.L., P.T.M., R.E.W.), University of Cincinnati College of Medicine (A.L., P.T.M., R.E.W.), and the Global Health Center, Cincinnati Children's Hospital Medical Center (S.E.S., P.T.M., R.E.W.), Cincinnati; and Cohen Children's Medical Center, New Hyde Park, and the Zucker School of Medicine at Hofstra/Northwell, Hempstead - both in New York (B.A.).
Stuber SE; From Centre Hospitalier Monkole, Kinshasa, Democratic Republic of Congo (L.T.); the Department of Medicine, University Health Network and Mt. Sinai Hospital, and the University of Toronto, Toronto (G.T.); the Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Program, Kilifi, Kenya (T.N.W.); the Department of Medicine, Imperial College London, London (T.N.W.); Hospital Pediátrico David Bernardino, Luanda, Angola (B.S.); Mbale Clinical Research Institute and Mbale Regional Referral and Teaching Hospital-Busitema University, Mbale, Uganda (P.O.-O.); the Division of Hematology, Department of Pediatrics, Cincinnati Children's Hospital (A.L., S.E.S., T.S.L., P.T.M., R.E.W.), University of Cincinnati College of Medicine (A.L., P.T.M., R.E.W.), and the Global Health Center, Cincinnati Children's Hospital Medical Center (S.E.S., P.T.M., R.E.W.), Cincinnati; and Cohen Children's Medical Center, New Hyde Park, and the Zucker School of Medicine at Hofstra/Northwell, Hempstead - both in New York (B.A.).
Latham TS; From Centre Hospitalier Monkole, Kinshasa, Democratic Republic of Congo (L.T.); the Department of Medicine, University Health Network and Mt. Sinai Hospital, and the University of Toronto, Toronto (G.T.); the Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Program, Kilifi, Kenya (T.N.W.); the Department of Medicine, Imperial College London, London (T.N.W.); Hospital Pediátrico David Bernardino, Luanda, Angola (B.S.); Mbale Clinical Research Institute and Mbale Regional Referral and Teaching Hospital-Busitema University, Mbale, Uganda (P.O.-O.); the Division of Hematology, Department of Pediatrics, Cincinnati Children's Hospital (A.L., S.E.S., T.S.L., P.T.M., R.E.W.), University of Cincinnati College of Medicine (A.L., P.T.M., R.E.W.), and the Global Health Center, Cincinnati Children's Hospital Medical Center (S.E.S., P.T.M., R.E.W.), Cincinnati; and Cohen Children's Medical Center, New Hyde Park, and the Zucker School of Medicine at Hofstra/Northwell, Hempstead - both in New York (B.A.).
McGann PT; From Centre Hospitalier Monkole, Kinshasa, Democratic Republic of Congo (L.T.); the Department of Medicine, University Health Network and Mt. Sinai Hospital, and the University of Toronto, Toronto (G.T.); the Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Program, Kilifi, Kenya (T.N.W.); the Department of Medicine, Imperial College London, London (T.N.W.); Hospital Pediátrico David Bernardino, Luanda, Angola (B.S.); Mbale Clinical Research Institute and Mbale Regional Referral and Teaching Hospital-Busitema University, Mbale, Uganda (P.O.-O.); the Division of Hematology, Department of Pediatrics, Cincinnati Children's Hospital (A.L., S.E.S., T.S.L., P.T.M., R.E.W.), University of Cincinnati College of Medicine (A.L., P.T.M., R.E.W.), and the Global Health Center, Cincinnati Children's Hospital Medical Center (S.E.S., P.T.M., R.E.W.), Cincinnati; and Cohen Children's Medical Center, New Hyde Park, and the Zucker School of Medicine at Hofstra/Northwell, Hempstead - both in New York (B.A.).
Ware RE; From Centre Hospitalier Monkole, Kinshasa, Democratic Republic of Congo (L.T.); the Department of Medicine, University Health Network and Mt. Sinai Hospital, and the University of Toronto, Toronto (G.T.); the Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Program, Kilifi, Kenya (T.N.W.); the Department of Medicine, Imperial College London, London (T.N.W.); Hospital Pediátrico David Bernardino, Luanda, Angola (B.S.); Mbale Clinical Research Institute and Mbale Regional Referral and Teaching Hospital-Busitema University, Mbale, Uganda (P.O.-O.); the Division of Hematology, Department of Pediatrics, Cincinnati Children's Hospital (A.L., S.E.S., T.S.L., P.T.M., R.E.W.), University of Cincinnati College of Medicine (A.L., P.T.M., R.E.W.), and the Global Health Center, Cincinnati Children's Hospital Medical Center (S.E.S., P.T.M., R.E.W.), Cincinnati; and Cohen Children's Medical Center, New Hyde Park, and the Zucker School of Medicine at Hofstra/Northwell, Hempstead - both in New York (B.A.).
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Corporate Authors :
REACH Investigators
Źródło :
The New England journal of medicine [N Engl J Med] 2019 Jan 10; Vol. 380 (2), pp. 121-131. Date of Electronic Publication: 2018 Dec 01.
Typ publikacji :
Clinical Trial, Phase I; Clinical Trial, Phase II; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Anemia, Sickle Cell/*drug therapy
Antisickling Agents/*administration & dosage
Hydroxyurea/*administration & dosage
Africa South of the Sahara/epidemiology ; Anemia, Sickle Cell/complications ; Anemia, Sickle Cell/mortality ; Antisickling Agents/adverse effects ; Child ; Child, Preschool ; Dose-Response Relationship, Drug ; Humans ; Hydroxyurea/adverse effects ; Infant ; Malaria/complications ; Malaria/prevention & control ; Neglected Diseases/drug therapy ; Pain/etiology ; Pain/prevention & control
Czasopismo naukowe
Tytuł :
Pharmacoproteomics Profiling of Plasma From β-Thalassemia Patients in Response to Hydroxyurea Treatment.
Autorzy :
Zohaib M; National Center for Proteomics, University of Karachi, Karachi, Pakistan.
Ansari SH; National Institute of Blood Diseases and Bone Marrow Transplantation, Karachi, Pakistan.
Shamsi TS; National Institute of Blood Diseases and Bone Marrow Transplantation, Karachi, Pakistan.
Zubarev RA; Division of Physiological Chemistry I, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.; Department of Pharmacological & Technological Chemistry, I.M. Sechenov First Moscow State Medical University, Moscow, Russia.
Zarina S; National Center for Proteomics, University of Karachi, Karachi, Pakistan.
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Źródło :
Journal of clinical pharmacology [J Clin Pharmacol] 2019 Jan; Vol. 59 (1), pp. 98-106. Date of Electronic Publication: 2018 Aug 27.
Typ publikacji :
Clinical Trial; Journal Article
MeSH Terms :
Antisickling Agents/*pharmacology
Hydroxyurea/*pharmacology
beta-Thalassemia/*blood
Antisickling Agents/therapeutic use ; Child, Preschool ; Female ; Humans ; Hydroxyurea/therapeutic use ; Infant ; Male ; Proteins/metabolism ; Proteomics ; beta-Thalassemia/drug therapy
Czasopismo naukowe
Tytuł :
Hydroxyurea in the management of sickle cell disease: pharmacogenomics and enzymatic metabolism.
Autorzy :
Yahouédéhou SCMA; Laboratório de Investigação em Genética e Hematologia Translacional - LIGHT, Instituto Gonçalo Moniz - IGM/FIOCRUZ, Salvador, Brazil.; Laboratório de Pesquisa em Anemia - LPA, Departamento de Análises Clínicas, Faculdade de Farmácia, Universidade Federal da Bahia, Salvador, Brazil.
Adorno EV; Laboratório de Pesquisa em Anemia - LPA, Departamento de Análises Clínicas, Faculdade de Farmácia, Universidade Federal da Bahia, Salvador, Brazil.
da Guarda CC; Laboratório de Investigação em Genética e Hematologia Translacional - LIGHT, Instituto Gonçalo Moniz - IGM/FIOCRUZ, Salvador, Brazil.
Ndidi US; Laboratório de Investigação em Genética e Hematologia Translacional - LIGHT, Instituto Gonçalo Moniz - IGM/FIOCRUZ, Salvador, Brazil.
Carvalho SP; Laboratório de Investigação em Genética e Hematologia Translacional - LIGHT, Instituto Gonçalo Moniz - IGM/FIOCRUZ, Salvador, Brazil.; Laboratório de Pesquisa em Anemia - LPA, Departamento de Análises Clínicas, Faculdade de Farmácia, Universidade Federal da Bahia, Salvador, Brazil.
Santiago RP; Laboratório de Investigação em Genética e Hematologia Translacional - LIGHT, Instituto Gonçalo Moniz - IGM/FIOCRUZ, Salvador, Brazil.
Aleluia MM; Laboratório de Investigação em Genética e Hematologia Translacional - LIGHT, Instituto Gonçalo Moniz - IGM/FIOCRUZ, Salvador, Brazil.
de Oliveira RM; Laboratório de Investigação em Genética e Hematologia Translacional - LIGHT, Instituto Gonçalo Moniz - IGM/FIOCRUZ, Salvador, Brazil.; Laboratório de Pesquisa em Anemia - LPA, Departamento de Análises Clínicas, Faculdade de Farmácia, Universidade Federal da Bahia, Salvador, Brazil.
Gonçalves MS; Laboratório de Investigação em Genética e Hematologia Translacional - LIGHT, Instituto Gonçalo Moniz - IGM/FIOCRUZ, Salvador, Brazil. .; Laboratório de Pesquisa em Anemia - LPA, Departamento de Análises Clínicas, Faculdade de Farmácia, Universidade Federal da Bahia, Salvador, Brazil. .
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Źródło :
The pharmacogenomics journal [Pharmacogenomics J] 2018 Dec; Vol. 18 (6), pp. 730-739. Date of Electronic Publication: 2018 Sep 12.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Pharmacogenomic Variants*
Anemia, Sickle Cell/*drug therapy
Antisickling Agents/*therapeutic use
Enzymes/*genetics
Hydroxyurea/*therapeutic use
Membrane Transport Proteins/*genetics
Anemia, Sickle Cell/diagnosis ; Antisickling Agents/adverse effects ; Antisickling Agents/metabolism ; Enzymes/metabolism ; Humans ; Hydroxyurea/adverse effects ; Hydroxyurea/metabolism ; Membrane Transport Proteins/metabolism ; Pharmacogenetics ; Pharmacogenomic Testing ; Quantitative Trait Loci ; Risk Factors ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Increasing hydroxyurea use in children with sickle cell disease at Kamuzu Central Hospital, Malawi.
Autorzy :
Mvalo T; University of North Carolina Project-Malawi, Lilongwe, Malawi.; Department of Pediatrics.
Topazian H; University of North Carolina Project-Malawi, Lilongwe, Malawi.; Department of Epidemiology, and.
Kamthunzi P; University of North Carolina Project-Malawi, Lilongwe, Malawi.; Institute for Global Health and Infectious Diseases, University of North Carolina, Chapel Hill, NC.
Chen J; University of North Carolina Project-Malawi, Lilongwe, Malawi.; Department of Epidemiology, and.
Kambalame I; University of North Carolina Project-Malawi, Lilongwe, Malawi.
Mafunga P; University of North Carolina Project-Malawi, Lilongwe, Malawi.
Mumba N; University of North Carolina Project-Malawi, Lilongwe, Malawi.
Chiume-Chiphaliwali M; Department of Pediatrics, and.
Paseli K; Ministry of Health, Kamuzu Central Hospital, Lilongwe, Malawi; and.
Key N; Division of Hematology, and.
Gopal S; University of North Carolina Project-Malawi, Lilongwe, Malawi.; Institute for Global Health and Infectious Diseases, University of North Carolina, Chapel Hill, NC.
Hoffman I; University of North Carolina Project-Malawi, Lilongwe, Malawi.; Institute for Global Health and Infectious Diseases, University of North Carolina, Chapel Hill, NC.
Ataga K; Division of Hematology, and.
Westmoreland K; University of North Carolina Project-Malawi, Lilongwe, Malawi.; Division of Pediatric Hematology-Oncology, University of North Carolina, Chapel Hill, NC.
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Źródło :
Blood advances [Blood Adv] 2018 Nov 30; Vol. 2 (Suppl 1), pp. 30-32.
Typ publikacji :
Journal Article; Observational Study; Research Support, N.I.H., Extramural
MeSH Terms :
Anemia, Sickle Cell/*drug therapy
Antisickling Agents/*therapeutic use
Hydroxyurea/*therapeutic use
Adolescent ; Anemia, Sickle Cell/blood ; Anemia, Sickle Cell/epidemiology ; Anemia, Sickle Cell/urine ; Antisickling Agents/administration & dosage ; Antisickling Agents/adverse effects ; Child ; Child, Preschool ; Female ; Hospitals, Teaching ; Humans ; Hydroxyurea/administration & dosage ; Hydroxyurea/adverse effects ; Infant ; Malawi/epidemiology ; Male ; Prospective Studies
Czasopismo naukowe
Tytuł :
Liver Transplantation for Acute Liver Failure Secondary to Acute Sickle Intrahepatic Cholestasis.
Autorzy :
Racho RG; Department of Transplantation, Mayo Clinic, Jacksonville, Florida, USA.
Krishna M; Department of Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, Florida, USA.
Canabal JM; Department of Transplantation, Mayo Clinic, Jacksonville, Florida, USA.
Keaveny AP; Department of Transplantation, Mayo Clinic, Jacksonville, Florida, USA.
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Źródło :
The American journal of gastroenterology [Am J Gastroenterol] 2020 Jun; Vol. 115 (6), pp. 809.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Liver Transplantation*
Anemia, Sickle Cell/*complications
Cholestasis, Intrahepatic/*etiology
Liver Failure, Acute/*etiology
beta-Thalassemia/*complications
Acute Disease ; Anemia, Sickle Cell/drug therapy ; Antisickling Agents/therapeutic use ; Bradycardia/therapy ; Budd-Chiari Syndrome/etiology ; Budd-Chiari Syndrome/pathology ; Cardiopulmonary Resuscitation ; Cholestasis, Intrahepatic/pathology ; Cholestasis, Intrahepatic/surgery ; Glucocorticoids/therapeutic use ; Graft Rejection/prevention & control ; Heart Arrest/therapy ; Humans ; Hydroxyurea/therapeutic use ; Immunosuppressive Agents/therapeutic use ; Liver Failure, Acute/pathology ; Liver Failure, Acute/surgery ; Male ; Postoperative Complications/therapy ; Prednisone/therapeutic use ; Tacrolimus ; Young Adult
Czasopismo naukowe
Tytuł :
Higher oxygen saturation with hydroxyurea in paediatric sickle cell disease.
Autorzy :
van Geyzel L; Department of Paediatric Respiratory Medicine, King's College Hospital NHS Foundation Trust, London, UK.
Arigliani M; Department of Medicine, Division of Pediatrics, University Hospital of Udine, Udine, Italy.
Inusa B; Department of Paediatric Haematology, Guy's & St Thomas' NHS Foundation Trust, London, UK.
Singh B; Department of Paediatric Respiratory Medicine, King's College Hospital NHS Foundation Trust, London, UK.
Kozlowska W; Department of Paediatric Respiratory Medicine, King's College Hospital NHS Foundation Trust, London, UK.; Department of Paediatric Respiratory Medicine, Addenbrooke's Hospital, Cambridge, Cambridgeshire, UK.
Chakravorty S; Department of Paediatric Haematology, King's College Hospital NHS Foundation Trust, London, UK.
Bossley CJ; Department of Paediatric Respiratory Medicine, King's College Hospital NHS Foundation Trust, London, UK.
Ruiz G; Department of Paediatric Respiratory Medicine, King's College Hospital NHS Foundation Trust, London, UK.
Rees D; Department of Paediatric Haematology, King's College Hospital NHS Foundation Trust, London, UK.
Gupta A; Department of Paediatric Respiratory Medicine, King's College Hospital NHS Foundation Trust, London, UK .
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Źródło :
Archives of disease in childhood [Arch Dis Child] 2020 Jun; Vol. 105 (6), pp. 575-579. Date of Electronic Publication: 2019 Dec 23.
Typ publikacji :
Journal Article
MeSH Terms :
Anemia, Sickle Cell/*drug therapy
Antisickling Agents/*therapeutic use
Hydroxyurea/*therapeutic use
Oxygen/*blood
Adolescent ; Anemia, Sickle Cell/blood ; Child ; Child, Preschool ; Female ; Humans ; Infant ; Longitudinal Studies ; Male ; Oximetry ; Retrospective Studies
Czasopismo naukowe
Tytuł :
Initiating adjunct low-dose hydroxyurea therapy for stroke prevention in children with SCA during the COVID-19 pandemic.
Autorzy :
DeBaun MR
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Źródło :
Blood [Blood] 2020 May 28; Vol. 135 (22), pp. 1997-1999.
Typ publikacji :
Letter
MeSH Terms :
Blood Transfusion*
Anemia, Sickle Cell/*therapy
Antisickling Agents/*therapeutic use
Coronavirus Infections/*epidemiology
Hydroxyurea/*therapeutic use
Pneumonia, Viral/*epidemiology
Stroke/*prevention & control
Anemia, Sickle Cell/complications ; Blood Donors/supply & distribution ; Blood Safety ; Child ; Child, Preschool ; Humans ; Pandemics ; Risk Factors ; Secondary Prevention ; Stroke/etiology
SCR Disease Name :
COVID-19
Opinia redakcyjna

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