Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ

Wyszukujesz frazę ""Antiviral Agents"" wg kryterium: Temat


Starter badań:

Tytuł :
Dissecting the novel mechanism of reduning injection in treating Coronavirus Disease 2019 (COVID-19) based on network pharmacology and experimental verification.
Autorzy :
Jia S; Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China. Electronic address: .
Luo H; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, 999078, China. Electronic address: .
Liu X; Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China. Electronic address: .
Fan X; Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China. Electronic address: .
Huang Z; Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China. Electronic address: .
Lu S; Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China. Electronic address: .
Shen L; Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China. Electronic address: .
Guo S; Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China. Electronic address: .
Liu Y; Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China. Electronic address: .
Wang Z; State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang, Jiangsu, 222001, China; The Key Laboratory for the New Technique Research of TCM Extraction and Purification, Lianyungang, Jiangsu, 222047, China. Electronic address: .
Cao L; State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang, Jiangsu, 222001, China; The Key Laboratory for the New Technique Research of TCM Extraction and Purification, Lianyungang, Jiangsu, 222047, China. Electronic address: .
Cao Z; State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang, Jiangsu, 222001, China; The Key Laboratory for the New Technique Research of TCM Extraction and Purification, Lianyungang, Jiangsu, 222047, China. Electronic address: .
Zhang X; State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang, Jiangsu, 222001, China; The Key Laboratory for the New Technique Research of TCM Extraction and Purification, Lianyungang, Jiangsu, 222047, China. Electronic address: .
Zhou W; Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China. Electronic address: .
Zhang J; Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China. Electronic address: .
Li J; Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China. Electronic address: .
Wu J; Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China. Electronic address: .
Xiao W; State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang, Jiangsu, 222001, China; The Key Laboratory for the New Technique Research of TCM Extraction and Purification, Lianyungang, Jiangsu, 222047, China. Electronic address: .
Pokaż więcej
Źródło :
Journal of ethnopharmacology [J Ethnopharmacol] 2021 Jun 12; Vol. 273, pp. 113871. Date of Electronic Publication: 2021 Jan 22.
Typ publikacji :
Journal Article
MeSH Terms :
Antiviral Agents/*pharmacology
Antiviral Agents/*therapeutic use
COVID-19/*drug therapy
Drugs, Chinese Herbal/*pharmacology
Drugs, Chinese Herbal/*therapeutic use
Angiotensin-Converting Enzyme 2/metabolism ; Animals ; Antiviral Agents/chemistry ; Antiviral Agents/toxicity ; Cell Line, Transformed ; Chlorocebus aethiops ; Computational Biology ; Coronavirus 3C Proteases/metabolism ; Coronavirus Papain-Like Proteases/metabolism ; Cytokines/metabolism ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/toxicity ; Humans ; Medicine, Chinese Traditional/methods ; Molecular Docking Simulation ; Protein Array Analysis ; SARS-CoV-2/drug effects ; Signal Transduction/drug effects ; Vero Cells
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Antiviral activities and applications of ribosomally synthesized and post-translationally modified peptides (RiPPs).
Autorzy :
Fu Y; Department of Molecular Genetics, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, 9747 AG, Groningen, The Netherlands.
Jaarsma AH; Department of Molecular Genetics, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, 9747 AG, Groningen, The Netherlands.; Department of Environmental Science, Aarhus University, 4000, Roskilde, Denmark.
Kuipers OP; Department of Molecular Genetics, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, 9747 AG, Groningen, The Netherlands. .
Pokaż więcej
Źródło :
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2021 Apr; Vol. 78 (8), pp. 3921-3940. Date of Electronic Publication: 2021 Feb 02.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Drug Discovery*
Protein Processing, Post-Translational*
Antiviral Agents/*chemistry
Antiviral Agents/*pharmacology
Peptides/*chemistry
Peptides/*pharmacology
Animals ; Antiviral Agents/administration & dosage ; Antiviral Agents/metabolism ; Drug Delivery Systems ; Humans ; Peptides/administration & dosage ; Peptides/metabolism ; Ribosomes/metabolism ; Virus Diseases/drug therapy ; Viruses/drug effects
Czasopismo naukowe
Tytuł :
Exploitation of polyphenols and proteins using nanoencapsulation for anti-viral and brain boosting properties - Evoking a synergistic strategy to combat COVID-19 pandemic.
Autorzy :
Noor N; Laboratory of Functional Food and Nutraceuticals, Department of Food Science and Technology, University of Kashmir, Srinagar 190006, India.
Gani A; Laboratory of Functional Food and Nutraceuticals, Department of Food Science and Technology, University of Kashmir, Srinagar 190006, India; Department of Food Science, Rutgers University, 65 Dudley Road, New Brunswick, NJ 08901, United States. Electronic address: .
Gani A; Laboratory of Functional Food and Nutraceuticals, Department of Food Science and Technology, University of Kashmir, Srinagar 190006, India.
Shah A; Laboratory of Functional Food and Nutraceuticals, Department of Food Science and Technology, University of Kashmir, Srinagar 190006, India.
Ashraf ZU; Laboratory of Functional Food and Nutraceuticals, Department of Food Science and Technology, University of Kashmir, Srinagar 190006, India.
Pokaż więcej
Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2021 Jun 01; Vol. 180, pp. 375-384. Date of Electronic Publication: 2021 Mar 11.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antiviral Agents*/chemistry
Antiviral Agents*/therapeutic use
COVID-19*/epidemiology
Mental Health*
Nanocapsules*/chemistry
Nanocapsules*/therapeutic use
Pandemics*
Polyphenols*/chemistry
Polyphenols*/therapeutic use
SARS-CoV-2*
Humans
Czasopismo naukowe
Tytuł :
Integrative web-based analysis of omics data for study of drugs against SARS-CoV-2.
Autorzy :
Wang Z; Department of Biomedical Engineering, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, 100005, China.
He Y; Unit for Laboratory Animal Medicine, Department of Microbiology and Immunology, Center for Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, MI, 48105, USA.
Huang J; Department of Respiratory and Critical Care Medicine, Chongqing General Hospital, University of Chinese Academy of Sciences, Chongqing, 400014, China.
Yang X; Department of Biomedical Engineering, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, 100005, China. .
Pokaż więcej
Źródło :
Scientific reports [Sci Rep] 2021 May 24; Vol. 11 (1), pp. 10763. Date of Electronic Publication: 2021 May 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
User-Computer Interface*
Antiviral Agents/*therapeutic use
COVID-19/*drug therapy
Angiotensin-Converting Enzyme 2/chemistry ; Angiotensin-Converting Enzyme 2/metabolism ; Antiviral Agents/chemistry ; Antiviral Agents/metabolism ; Antiviral Agents/pharmacology ; COVID-19/metabolism ; COVID-19/pathology ; COVID-19/virology ; Cell Line ; Chloroquine/pharmacology ; Gene Expression Regulation/drug effects ; Humans ; Internet ; Protein Binding ; Pyrazoles/pharmacology ; Severity of Illness Index
Czasopismo naukowe
Tytuł :
Attacking COVID-19 Progression Using Multi-Drug Therapy for Synergetic Target Engagement.
Autorzy :
Coban MA; Department of Cancer Biology, Mayo Clinic, 4500 San Pablo Road South, Jacksonville, FL 32224, USA.
Morrison J; Department of Microbiology and Plant Pathology, University of California, 900 University, Riverside, CA 92521, USA.
Maharjan S; Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 65 Landsdowne St, Cambridge, MA 02139, USA.
Hernandez Medina DH; Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 65 Landsdowne St, Cambridge, MA 02139, USA.
Li W; Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 65 Landsdowne St, Cambridge, MA 02139, USA.
Zhang YS; Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 65 Landsdowne St, Cambridge, MA 02139, USA.
Freeman WD; Department of Neurology, Mayo Clinic, 4500 San Pablo South, Jacksonville, FL 32224, USA.
Radisky ES; Department of Cancer Biology, Mayo Clinic, 4500 San Pablo Road South, Jacksonville, FL 32224, USA.
Le Roch KG; Department of Molecular, Cell and Systems Biology, University of California, 900 University, Riverside, CA 92521, USA.
Weisend CM; Department of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Ebihara H; Department of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Caulfield TR; Department of Cancer Biology, Mayo Clinic, 4500 San Pablo Road South, Jacksonville, FL 32224, USA.; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.; Department of Quantitative Health Science, Division of Computational Biology, Mayo Clinic, Jacksonville, FL 32224, USA.; Department of Clinical Genomics, Mayo Clinic, Rochester, MN 55905, USA.; Department of Biochemistry & Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA.
Pokaż więcej
Źródło :
Biomolecules [Biomolecules] 2021 May 23; Vol. 11 (6). Date of Electronic Publication: 2021 May 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antiviral Agents/*therapeutic use
COVID-19/*drug therapy
Angiotensin-Converting Enzyme 2/chemistry ; Angiotensin-Converting Enzyme 2/metabolism ; Antiviral Agents/chemistry ; Antiviral Agents/metabolism ; Antiviral Agents/pharmacology ; Binding Sites ; COVID-19/pathology ; COVID-19/virology ; Drug Discovery ; Drug Repositioning ; Humans ; Machine Learning ; Molecular Docking Simulation ; SARS-CoV-2/drug effects ; SARS-CoV-2/isolation & purification ; SARS-CoV-2/metabolism ; Serine Endopeptidases/chemistry ; Serine Endopeptidases/metabolism ; Viral Envelope Proteins/antagonists & inhibitors ; Viral Envelope Proteins/metabolism ; Virus Replication/drug effects
Czasopismo naukowe
Tytuł :
SARS-CoV-2 main protease inhibition by compounds isolated from Luffa cylindrica using molecular docking.
Autorzy :
Cao TQ; College of Pharmacy, Drug Research and Development Center, Daegu Catholic University, Gyeongbuk 38430, Republic of Korea; Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan 54538, Republic of Korea.
Kim JA; College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu 41566, Republic of Korea.
Woo MH; College of Pharmacy, Drug Research and Development Center, Daegu Catholic University, Gyeongbuk 38430, Republic of Korea.
Min BS; College of Pharmacy, Drug Research and Development Center, Daegu Catholic University, Gyeongbuk 38430, Republic of Korea. Electronic address: .
Pokaż więcej
Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2021 May 15; Vol. 40, pp. 127972. Date of Electronic Publication: 2021 Mar 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antiviral Agents/*metabolism
Coronavirus 3C Proteases/*metabolism
Cysteine Proteinase Inhibitors/*metabolism
Luffa/*chemistry
SARS-CoV-2/*drug effects
Saponins/*metabolism
Antiviral Agents/chemistry ; Antiviral Agents/isolation & purification ; Catalytic Domain ; Coronavirus 3C Proteases/chemistry ; Cysteine Proteinase Inhibitors/chemistry ; Cysteine Proteinase Inhibitors/isolation & purification ; Fruit/chemistry ; Molecular Docking Simulation ; Protein Binding ; Saponins/chemistry ; Saponins/isolation & purification
Czasopismo naukowe
Tytuł :
Application of niclosamide and analogs as small molecule inhibitors of Zika virus and SARS-CoV-2 infection.
Autorzy :
Shamim K; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3370, USA. Electronic address: .
Xu M; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3370, USA.
Hu X; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3370, USA.
Lee EM; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3370, USA; Department of Biological Science, Florida State University, Tallahassee, FL 32306, USA.
Lu X; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3370, USA.
Huang R; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3370, USA.
Shah P; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3370, USA.
Xu X; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3370, USA.
Chen CZ; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3370, USA.
Shen M; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3370, USA.
Guo H; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3370, USA.
Chen L; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3370, USA.
Itkin Z; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3370, USA.
Eastman RT; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3370, USA.
Shinn P; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3370, USA.
Klumpp-Thomas C; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3370, USA.
Michael S; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3370, USA.
Simeonov A; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3370, USA.
Lo DC; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3370, USA.
Ming GL; Department of Neuroscience and Mahoney Institute for Neurosciences, University of Pennsylvania, Philadelphia, PA 19104, USA.
Song H; Department of Neuroscience and Mahoney Institute for Neurosciences, University of Pennsylvania, Philadelphia, PA 19104, USA.
Tang H; Department of Biological Science, Florida State University, Tallahassee, FL 32306, USA.
Zheng W; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3370, USA.
Huang W; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3370, USA. Electronic address: .
Pokaż więcej
Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2021 May 15; Vol. 40, pp. 127906. Date of Electronic Publication: 2021 Mar 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Antiviral Agents/*pharmacology
Niclosamide/*analogs & derivatives
Niclosamide/*pharmacology
SARS-CoV-2/*drug effects
Zika Virus/*drug effects
Animals ; Antiviral Agents/chemical synthesis ; Antiviral Agents/metabolism ; Binding Sites ; Chlorocebus aethiops ; Drug Stability ; Humans ; Microbial Sensitivity Tests ; Microsomes, Liver/metabolism ; Molecular Docking Simulation ; Molecular Structure ; Niclosamide/metabolism ; Protein Binding ; Rats ; Serine Endopeptidases/chemistry ; Serine Endopeptidases/metabolism ; Structure-Activity Relationship ; Vero Cells ; Viral Nonstructural Proteins/chemistry ; Viral Nonstructural Proteins/metabolism ; Viral Proteins/chemistry ; Viral Proteins/metabolism
Czasopismo naukowe
Tytuł :
Betulonic Acid Derivatives Interfering with Human Coronavirus 229E Replication via the nsp15 Endoribonuclease.
Autorzy :
Stevaert A; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven, 3000 Leuven, Belgium.
Krasniqi B; Molecular Design and Synthesis, Department of Chemistry, KU Leuven, 3001 Leuven, Belgium.
Van Loy B; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven, 3000 Leuven, Belgium.
Nguyen T; Biochemistry, Molecular and Structural Biology, Department of Chemistry, KU Leuven, 3001 Leuven, Belgium.
Thomas J; Molecular Design and Synthesis, Department of Chemistry, KU Leuven, 3001 Leuven, Belgium.
Vandeput J; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven, 3000 Leuven, Belgium.
Jochmans D; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven, 3000 Leuven, Belgium.
Thiel V; Institute of Virology and Immunology (IVI), 3012 Bern and 3012 Bern, Switzerland.; Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, 3012 Bern, Switzerland.
Dijkman R; Institute of Virology and Immunology (IVI), 3012 Bern and 3012 Bern, Switzerland.; Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, 3012 Bern, Switzerland.; Institute for Infectious Diseases (IFIK), University of Bern, 3012 Bern, Switzerland.
Dehaen W; Molecular Design and Synthesis, Department of Chemistry, KU Leuven, 3001 Leuven, Belgium.
Voet A; Biochemistry, Molecular and Structural Biology, Department of Chemistry, KU Leuven, 3001 Leuven, Belgium.
Naesens L; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven, 3000 Leuven, Belgium.
Pokaż więcej
Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 May 13; Vol. 64 (9), pp. 5632-5644. Date of Electronic Publication: 2021 Apr 20.
Typ publikacji :
Journal Article
MeSH Terms :
Antiviral Agents/*pharmacology
Coronavirus 229E, Human/*drug effects
Coronavirus 229E, Human/*enzymology
Endoribonucleases/*antagonists & inhibitors
Enzyme Inhibitors/*pharmacology
Oleanolic Acid/*analogs & derivatives
Viral Nonstructural Proteins/*antagonists & inhibitors
Virus Replication/*drug effects
Antiviral Agents/chemical synthesis ; Antiviral Agents/chemistry ; Cell Line ; Dose-Response Relationship, Drug ; Endoribonucleases/metabolism ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry ; Humans ; Microbial Sensitivity Tests ; Models, Molecular ; Oleanolic Acid/chemical synthesis ; Oleanolic Acid/chemistry ; Oleanolic Acid/pharmacology ; Viral Nonstructural Proteins/metabolism
Czasopismo naukowe
Tytuł :
Potential effect of Maxing Shigan decoction against coronavirus disease 2019 (COVID-19) revealed by network pharmacology and experimental verification.
Autorzy :
Li Y; School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Liangxiang University Town, Fangshan District, Beijing, 102488, China; Dongzhimen Hospital, Beijing University of Chinese Medicine, Dongcheng District, Hai Yun Cang on the 5th, Beijing, 100700, China.
Chu F; School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Liangxiang University Town, Fangshan District, Beijing, 102488, China; Institute of Regulatory Science for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Liangxiang University Town, Fangshan District, Beijing, 102488, China.
Li P; Dongzhimen Hospital, Beijing University of Chinese Medicine, Dongcheng District, Hai Yun Cang on the 5th, Beijing, 100700, China.
Johnson N; International School, Beijing University of Chinese Medicine, No. 11, Bei San Huan Dong Lu, Chaoyang District, Beijing, 100029, China.
Li T; Dongzhimen Hospital, Beijing University of Chinese Medicine, Dongcheng District, Hai Yun Cang on the 5th, Beijing, 100700, China.
Wang Y; School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Liangxiang University Town, Fangshan District, Beijing, 102488, China.
An R; Dongzhimen Hospital, Beijing University of Chinese Medicine, Dongcheng District, Hai Yun Cang on the 5th, Beijing, 100700, China.
Wu D; Dongzhimen Hospital, Beijing University of Chinese Medicine, Dongcheng District, Hai Yun Cang on the 5th, Beijing, 100700, China.
Chen J; School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Liangxiang University Town, Fangshan District, Beijing, 102488, China.
Su Z; School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Liangxiang University Town, Fangshan District, Beijing, 102488, China.
Gu X; School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Liangxiang University Town, Fangshan District, Beijing, 102488, China. Electronic address: .
Ding X; School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Liangxiang University Town, Fangshan District, Beijing, 102488, China. Electronic address: .
Pokaż więcej
Źródło :
Journal of ethnopharmacology [J Ethnopharmacol] 2021 May 10; Vol. 271, pp. 113854. Date of Electronic Publication: 2021 Jan 26.
Typ publikacji :
Journal Article
MeSH Terms :
Alveolar Epithelial Cells/*drug effects
Anti-Inflammatory Agents/*pharmacology
Antiviral Agents/*pharmacology
COVID-19/*drug therapy
Drugs, Chinese Herbal/*pharmacology
Alveolar Epithelial Cells/immunology ; Angiotensin-Converting Enzyme 2/antagonists & inhibitors ; Angiotensin-Converting Enzyme 2/metabolism ; Animals ; Anti-Inflammatory Agents/chemistry ; Anti-Inflammatory Agents/therapeutic use ; Antiviral Agents/chemistry ; Antiviral Agents/therapeutic use ; COVID-19/immunology ; COVID-19/virology ; Cell Line ; Computational Biology ; Coronavirus 3C Proteases/antagonists & inhibitors ; Coronavirus 3C Proteases/metabolism ; Drug Evaluation, Preclinical ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/therapeutic use ; Humans ; Interleukin-6/immunology ; Janus Kinases/metabolism ; Medicine, Chinese Traditional/methods ; Molecular Docking Simulation ; Phosphorylation/drug effects ; Protein Interaction Maps/drug effects ; RNA-Dependent RNA Polymerase/antagonists & inhibitors ; RNA-Dependent RNA Polymerase/metabolism ; Rats ; SARS-CoV-2/immunology ; STAT Transcription Factors/metabolism ; Signal Transduction/drug effects ; Signal Transduction/immunology
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Emergent Drug and Nutrition Interactions in COVID-19: A Comprehensive Narrative Review.
Autorzy :
Ağagündüz D; Department of Nutrition and Dietetics, Faculty of Health Sciences, Gazi University, Emek, Ankara 06490, Turkey.
Çelik MN; Department of Nutrition and Dietetics, Faculty of Health Sciences, Gazi University, Emek, Ankara 06490, Turkey.
Çıtar Dazıroğlu ME; Department of Nutrition and Dietetics, Faculty of Health Sciences, Gazi University, Emek, Ankara 06490, Turkey.
Capasso R; Department of Agricultural Sciences, University of Naples Federico II, 80055 Naples, Italy.
Pokaż więcej
Źródło :
Nutrients [Nutrients] 2021 May 04; Vol. 13 (5). Date of Electronic Publication: 2021 May 04.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antiviral Agents*/pharmacokinetics
Antiviral Agents*/therapeutic use
Food-Drug Interactions*
SARS-CoV-2*
COVID-19/*drug therapy
Age Factors ; COVID-19/epidemiology ; Humans
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Potential "biopeptidal" therapeutics for severe respiratory syndrome coronaviruses: a review of antiviral peptides, viral mechanisms, and prospective needs.
Autorzy :
Ashaolu TJ; Institute of Research and Development, Duy Tan University, Da Nang, 550000, Vietnam.; Faculty of Environmental and Chemical Engineering, Duy Tan University, Da Nang, 550000, Vietnam.
Nawaz A; Jiangsu Key Laboratory of Crop Genetics and Physiology, Key Laboratory of Plant Functional Genomics of the Ministry of Education, College of Agriculture, Yangzhou University, Yangzhou, People's Republic of China.
Walayat N; Department of Food Science and Engineering, College of Ocean, Zhejiang University of Technology, Hangzhou, People's Republic of China.
Khalifa I; Food Technology Department, Faculty of Agriculture, Banha University, 13736, Moshtohor, Cairo, Egypt. .
Pokaż więcej
Źródło :
Applied microbiology and biotechnology [Appl Microbiol Biotechnol] 2021 May; Vol. 105 (9), pp. 3457-3470. Date of Electronic Publication: 2021 Apr 19.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antiviral Agents*/pharmacology
Antiviral Agents*/therapeutic use
COVID-19*
Animals ; Humans ; Peptides ; Prospective Studies ; SARS-CoV-2
Czasopismo naukowe
Tytuł :
RECOVERY 1 year on: a rare success in the COVID-19 clinical trial landscape.
Autorzy :
Mullard A
Pokaż więcej
Źródło :
Nature reviews. Drug discovery [Nat Rev Drug Discov] 2021 May; Vol. 20 (5), pp. 336-337.
Typ publikacji :
Wiadomości
MeSH Terms :
Antiviral Agents*/classification
Antiviral Agents*/pharmacology
Clinical Trials as Topic*/methods
Clinical Trials as Topic*/organization & administration
Clinical Trials as Topic*/standards
COVID-19/*drug therapy
COVID-19/epidemiology ; Clinical Protocols ; Communicable Diseases, Emerging/therapy ; Humans ; Research Design/standards ; SARS-CoV-2 ; Treatment Outcome ; United Kingdom
SCR Protocol :
COVID-19 drug treatment
Periodyk
Tytuł :
Clofazimine broadly inhibits coronaviruses including SARS-CoV-2.
Autorzy :
Yuan S; State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.; Department of Clinical Microbiology and Infection Control, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China.
Yin X; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China.; Immunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Meng X; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Chan JF; State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.; Department of Clinical Microbiology and Infection Control, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China.; Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, Hainan Medical University and The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Ye ZW; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Riva L; Immunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.; Calibr, Scripps Research, La Jolla, CA, USA.
Pache L; Immunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Chan CC; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Lai PM; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Chan CC; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Poon VK; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Lee AC; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Matsunaga N; Immunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Pu Y; Immunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Yuen CK; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Cao J; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Liang R; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Tang K; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Sheng L; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Du Y; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Xu W; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Lau CY; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Sit KY; Department of Surgery, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong SAR, China.
Au WK; Department of Surgery, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong SAR, China.
Wang R; Department of Chemistry, State Key Laboratory of Synthetic Chemistry, CAS-HKU Joint Laboratory of Metallomics on Health and Environment, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Zhang YY; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China.
Tang YD; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China.
Clausen TM; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Copenhagen Center for Glycomics, Department of Molecular and Cellular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Pihl J; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Oh J; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Division of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.
Sze KH; State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Zhang AJ; State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Chu H; State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Kok KH; State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Wang D; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Division of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.
Cai XH; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China.
Esko JD; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Glycobiology Research and Training Center, University of California San Diego, La Jolla, CA, USA.
Hung IF; Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Li RA; Dr Li Dak-Sum Research Centre, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Chen H; State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Sun H; Department of Chemistry, State Key Laboratory of Synthetic Chemistry, CAS-HKU Joint Laboratory of Metallomics on Health and Environment, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Jin DY; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Sun R; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China. .; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA. .
Chanda SK; Immunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA. .
Yuen KY; State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China. .; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China. .; Department of Clinical Microbiology and Infection Control, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China. .; Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, Hainan Medical University and The University of Hong Kong, Pokfulam, Hong Kong SAR, China. .
Pokaż więcej
Źródło :
Nature [Nature] 2021 May; Vol. 593 (7859), pp. 418-423. Date of Electronic Publication: 2021 Mar 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antiviral Agents/*pharmacology
Clofazimine/*pharmacology
Coronavirus/*classification
Coronavirus/*drug effects
SARS-CoV-2/*drug effects
Adenosine Monophosphate/analogs & derivatives ; Adenosine Monophosphate/pharmacology ; Adenosine Monophosphate/therapeutic use ; Alanine/analogs & derivatives ; Alanine/pharmacology ; Alanine/therapeutic use ; Animals ; Anti-Inflammatory Agents/pharmacokinetics ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Antiviral Agents/pharmacokinetics ; Antiviral Agents/therapeutic use ; Biological Availability ; Cell Fusion ; Cell Line ; Clofazimine/pharmacokinetics ; Clofazimine/therapeutic use ; Coronavirus/growth & development ; Coronavirus/pathogenicity ; Cricetinae ; DNA Helicases/antagonists & inhibitors ; Drug Synergism ; Female ; Humans ; Life Cycle Stages/drug effects ; Male ; Mesocricetus ; Pre-Exposure Prophylaxis ; SARS-CoV-2/growth & development ; Species Specificity ; Spike Glycoprotein, Coronavirus/antagonists & inhibitors ; Transcription, Genetic/drug effects ; Transcription, Genetic/genetics
Czasopismo naukowe
Tytuł :
Emetine suppresses SARS-CoV-2 replication by inhibiting interaction of viral mRNA with eIF4E.
Autorzy :
Kumar R; National Centre for Veterinary Type Cultures, ICAR-National Research Centre on Equines, Hisar, India.
Afsar M; Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bengaluru, India.
Khandelwal N; National Centre for Veterinary Type Cultures, ICAR-National Research Centre on Equines, Hisar, India.
Chander Y; National Centre for Veterinary Type Cultures, ICAR-National Research Centre on Equines, Hisar, India.
Riyesh T; National Centre for Veterinary Type Cultures, ICAR-National Research Centre on Equines, Hisar, India.
Dedar RK; National Centre for Veterinary Type Cultures, ICAR-National Research Centre on Equines, Hisar, India.
Gulati BR; National Centre for Veterinary Type Cultures, ICAR-National Research Centre on Equines, Hisar, India.
Pal Y; National Centre for Veterinary Type Cultures, ICAR-National Research Centre on Equines, Hisar, India.
Barua S; National Centre for Veterinary Type Cultures, ICAR-National Research Centre on Equines, Hisar, India.
Tripathi BN; National Centre for Veterinary Type Cultures, ICAR-National Research Centre on Equines, Hisar, India. Electronic address: .
Hussain T; Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bengaluru, India. Electronic address: .
Kumar N; National Centre for Veterinary Type Cultures, ICAR-National Research Centre on Equines, Hisar, India. Electronic address: .
Pokaż więcej
Źródło :
Antiviral research [Antiviral Res] 2021 May; Vol. 189, pp. 105056. Date of Electronic Publication: 2021 Mar 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antiviral Agents*/pharmacology
Antiviral Agents*/therapeutic use
Emetine*/pharmacology
Emetine*/therapeutic use
Infectious bronchitis virus/*drug effects
RNA, Viral/*metabolism
SARS-CoV-2/*drug effects
Animals ; Chick Embryo ; Chlorocebus aethiops ; Coronavirus Infections/drug therapy ; Eukaryotic Initiation Factor-4E/metabolism ; Protein Binding/drug effects ; RNA, Messenger/metabolism ; Signal Transduction ; Vero Cells
Czasopismo naukowe
Tytuł :
Design, synthesis and biological evaluation of 2-aminoquinazolin-4(3H)-one derivatives as potential SARS-CoV-2 and MERS-CoV treatments.
Autorzy :
Lee JY; Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea.
Shin YS; Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea.
Jeon S; Zoonotic Virus Laboratory, Institut Pasteur Korea, Seongnam-si, Gyeonggi-do 13488, South Korea.
Lee SI; Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea.
Noh S; Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea.
Cho JE; Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea.
Jang MS; Department of Non-Clinical Studies, Korea Institute of Toxicology, Yuseong-gu, Daejeon 34114, South Korea.
Kim S; Zoonotic Virus Laboratory, Institut Pasteur Korea, Seongnam-si, Gyeonggi-do 13488, South Korea.
Song JH; Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea.
Kim HR; Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea.
Park CM; Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea; Korea University of Science and Technology, Daejeon 34114, South Korea. Electronic address: .
Pokaż więcej
Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2021 May 01; Vol. 39, pp. 127885. Date of Electronic Publication: 2021 Mar 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Design*
Antiviral Agents/*chemical synthesis
Middle East Respiratory Syndrome Coronavirus/*drug effects
Quinazolinones/*pharmacology
SARS-CoV-2/*drug effects
Animals ; Antiviral Agents/pharmacokinetics ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; COVID-19/drug therapy ; COVID-19/virology ; Cell Line ; Cell Survival/drug effects ; Coronavirus Infections/drug therapy ; Coronavirus Infections/virology ; Cytochrome P-450 Enzyme System/chemistry ; Cytochrome P-450 Enzyme System/metabolism ; Half-Life ; Humans ; Inhibitory Concentration 50 ; Mice ; Microsomes/metabolism ; Middle East Respiratory Syndrome Coronavirus/isolation & purification ; Quinazolinones/chemistry ; Quinazolinones/metabolism ; Quinazolinones/therapeutic use ; Rats ; SARS-CoV-2/isolation & purification ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Screening and evaluation of anti-SARS-CoV-2 components from Ephedra sinica by ACE2/CMC-HPLC-IT-TOF-MS approach.
Autorzy :
Lv Y; School of Pharmacy, Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China.; Institute of Pharmaceutical Science and Technology, Western China Science & Technology Innovation Harbour, Xi'an, 710115, Shaanxi, China.
Wang S; School of Pharmacy, Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China.; Institute of Pharmaceutical Science and Technology, Western China Science & Technology Innovation Harbour, Xi'an, 710115, Shaanxi, China.
Liang P; School of Pharmacy, Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China.; Institute of Pharmaceutical Science and Technology, Western China Science & Technology Innovation Harbour, Xi'an, 710115, Shaanxi, China.
Wang Y; School of Pharmacy, Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China.; Institute of Pharmaceutical Science and Technology, Western China Science & Technology Innovation Harbour, Xi'an, 710115, Shaanxi, China.
Zhang X; School of Pharmacy, Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China.; Institute of Pharmaceutical Science and Technology, Western China Science & Technology Innovation Harbour, Xi'an, 710115, Shaanxi, China.
Jia Q; School of Pharmacy, Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China.; Institute of Pharmaceutical Science and Technology, Western China Science & Technology Innovation Harbour, Xi'an, 710115, Shaanxi, China.
Fu J; School of Pharmacy, Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China.; Institute of Pharmaceutical Science and Technology, Western China Science & Technology Innovation Harbour, Xi'an, 710115, Shaanxi, China.
Han S; School of Pharmacy, Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China. .; Institute of Pharmaceutical Science and Technology, Western China Science & Technology Innovation Harbour, Xi'an, 710115, Shaanxi, China. .
He L; School of Pharmacy, Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China.; Institute of Pharmaceutical Science and Technology, Western China Science & Technology Innovation Harbour, Xi'an, 710115, Shaanxi, China.
Pokaż więcej
Źródło :
Analytical and bioanalytical chemistry [Anal Bioanal Chem] 2021 May; Vol. 413 (11), pp. 2995-3004. Date of Electronic Publication: 2021 Feb 19.
Typ publikacji :
Journal Article
MeSH Terms :
Ephedra sinica*/chemistry
Angiotensin-Converting Enzyme 2/*metabolism
Antiviral Agents/*pharmacology
COVID-19/*drug therapy
Drugs, Chinese Herbal/*pharmacology
SARS-CoV-2/*drug effects
Antiviral Agents/chemistry ; Antiviral Agents/isolation & purification ; COVID-19/metabolism ; China ; Chromatography, High Pressure Liquid ; Drug Discovery ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/isolation & purification ; Ephedrine/analogs & derivatives ; Ephedrine/isolation & purification ; Ephedrine/pharmacology ; HEK293 Cells ; Humans ; Mass Spectrometry ; Molecular Docking Simulation ; SARS-CoV-2/physiology ; Virus Internalization/drug effects
Czasopismo naukowe
Tytuł :
Volatile organic compounds profile synthesized and released by endophytes of tomato (Solanum lycopersici L.) and their antagonistic role.
Autorzy :
López SMY; Centro de Investigaciones en Fitopatología (CIDEFI), La Plata, Argentina. .; Comisión de Investigaciones Científicas de La Provincia de Buenos Aires (CICBA), La Plata, Argentina. .
Pastorino GN; Cátedra de Microbiología Agrícola, Universidad Nacional de La Plata (UNLP), Calle 60 y 119, La Plata, C. P. 1900, Buenos Aires, Argentina.
Balatti PA; Centro de Investigaciones en Fitopatología (CIDEFI), La Plata, Argentina.; Comisión de Investigaciones Científicas de La Provincia de Buenos Aires (CICBA), La Plata, Argentina.; Cátedra de Microbiología Agrícola, Universidad Nacional de La Plata (UNLP), Calle 60 y 119, La Plata, C. P. 1900, Buenos Aires, Argentina.
Pokaż więcej
Źródło :
Archives of microbiology [Arch Microbiol] 2021 May; Vol. 203 (4), pp. 1383-1397. Date of Electronic Publication: 2021 Jan 02.
Typ publikacji :
Journal Article
MeSH Terms :
Antiviral Agents/*pharmacology
Bacteria/*metabolism
Endophytes/*metabolism
Lycopersicon esculentum/*microbiology
Volatile Organic Compounds/*pharmacology
Antibiosis ; Antiviral Agents/isolation & purification ; Antiviral Agents/metabolism ; Bacteria/classification ; Bacteria/isolation & purification ; Endophytes/classification ; Endophytes/isolation & purification ; Fungi/drug effects ; Fungi/growth & development ; Pest Control, Biological ; Plant Diseases/microbiology ; Plant Diseases/prevention & control ; Volatile Organic Compounds/isolation & purification ; Volatile Organic Compounds/metabolism
Czasopismo naukowe
Tytuł :
Development of a Physiologically-Based Pharmacokinetic (PBPK) Model of Nebulized Hydroxychloroquine for Pulmonary Delivery to COVID-19 Patients.
Autorzy :
Idkaidek N; College of Pharmacy, University of Petra, Amman, Jordan.
Hawari F; Section of Pulmonary and Critical Care, Department of Internal Medicine, King Hussein Cancer Center and University of Jordan, Amman, Jordan.; Cancer Control Office, King Hussein Cancer Center, Amman, Jordan.
Dodin Y; Cancer Control Office, King Hussein Cancer Center, Amman, Jordan.
Obeidat N; Cancer Control Office, King Hussein Cancer Center, Amman, Jordan.
Pokaż więcej
Źródło :
Drug research [Drug Res (Stuttg)] 2021 May; Vol. 71 (5), pp. 250-256. Date of Electronic Publication: 2020 Dec 30.
Typ publikacji :
Journal Article
MeSH Terms :
Models, Biological*
Antiviral Agents/*pharmacokinetics
COVID-19/*drug therapy
Hydroxychloroquine/*pharmacokinetics
Lung/*metabolism
Administration, Inhalation ; Antiviral Agents/administration & dosage ; Antiviral Agents/blood ; Humans ; Hydroxychloroquine/administration & dosage ; Hydroxychloroquine/blood ; Lung/drug effects ; Nebulizers and Vaporizers ; Tissue Distribution
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Effective drugs used to combat SARS-CoV-2 infection and the current status of vaccines.
Autorzy :
Awadasseid A; Lab of Chemical Biology and Molecular Drug Design, College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014, China; Department of Biochemistry & Food Sciences, University of Kordofan, El-Obeid, 51111, Sudan.
Wu Y; Lab of Molecular Immunology, Virus Inspection Department, Zhejiang Provincial Center for Disease Control and Prevention, 630 Xincheng Road, Hangzhou, 310051, China. Electronic address: .
Tanaka Y; Center for Medical Innovation, Nagasaki University, 1-7-1 Sakamoto, Nagasaki, 852-8588, Japan.
Zhang W; Lab of Chemical Biology and Molecular Drug Design, College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014, China. Electronic address: .
Pokaż więcej
Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2021 May; Vol. 137, pp. 111330. Date of Electronic Publication: 2021 Jan 28.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antiviral Agents*/classification
Antiviral Agents*/pharmacology
COVID-19*/drug therapy
COVID-19*/prevention & control
COVID-19 Vaccines*/classification
COVID-19 Vaccines*/pharmacology
Humans ; SARS-CoV-2/drug effects ; SARS-CoV-2/physiology ; Treatment Outcome
Czasopismo naukowe
Tytuł :
An update review of emerging small-molecule therapeutic options for COVID-19.
Autorzy :
Tian D; School of Life Sciences, Jilin University, Changchun, 130012, PR China.
Liu Y; Faculty of Pharmacy, Shaanxi University of Science & Technology, Xi'an, 710021, PR China.
Liang C; School of Life Sciences, Jilin University, Changchun, 130012, PR China; Faculty of Pharmacy, Shaanxi University of Science & Technology, Xi'an, 710021, PR China. Electronic address: .
Xin L; Faculty of Pharmacy, Shaanxi University of Science & Technology, Xi'an, 710021, PR China.
Xie X; Shaanxi Panlong Pharmaceutical Group Co., Ltd., Xi'an, 710025, PR China.
Zhang D; Shaanxi Panlong Pharmaceutical Group Co., Ltd., Xi'an, 710025, PR China.
Wan M; School of Medicine and Pharmacy, Shaanxi University of Business & Commerce, Xi'an 712046, PR China.
Li H; Faculty of Pharmacy, Shaanxi University of Science & Technology, Xi'an, 710021, PR China.
Fu X; School of Life Sciences, Jilin University, Changchun, 130012, PR China.
Liu H; Zhuhai Jinan Selenium Source Nanotechnology Co., Ltd., Hengqin New Area, Zhuhai, 519030, PR China. Electronic address: .
Cao W; Zhuhai Jinan Selenium Source Nanotechnology Co., Ltd., Hengqin New Area, Zhuhai, 519030, PR China. Electronic address: .
Pokaż więcej
Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2021 May; Vol. 137, pp. 111313. Date of Electronic Publication: 2021 Feb 03.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antiviral Agents*/classification
Antiviral Agents*/pharmacology
COVID-19*/drug therapy
COVID-19*/metabolism
SARS-CoV-2*/drug effects
SARS-CoV-2*/enzymology
Molecular Targeted Therapy/*methods
Enzyme Inhibitors/pharmacology ; Humans ; Therapies, Investigational
Czasopismo naukowe

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies