Temat: "Antiviral Agents" - OpacWWW

Starter badań:

Antiviral drug types.

Antiviral drugs are medications used to prevent the replication of viruses in the cells of the human body during infection.

Salem Press Encyclopedia of Health, 2020. 2p.

Skocz do pozycji: 1 1.

Tytuł :: Dissecting the novel mechanism of reduning injection in treating Coronavirus Disease 2019 (COVID-19) based on network pharmacology and experimental verification.
Autorzy :: Jia S; Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China. Electronic address: .
Luo H; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, 999078, China. Electronic address: .
Liu X; Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China. Electronic address: .
Fan X; Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China. Electronic address: .
Huang Z; Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China. Electronic address: .
Lu S; Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China. Electronic address: .
Shen L; Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China. Electronic address: .
Guo S; Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China. Electronic address: .
Liu Y; Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China. Electronic address: .
Wang Z; State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang, Jiangsu, 222001, China; The Key Laboratory for the New Technique Research of TCM Extraction and Purification, Lianyungang, Jiangsu, 222047, China. Electronic address: .
Cao L; State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang, Jiangsu, 222001, China; The Key Laboratory for the New Technique Research of TCM Extraction and Purification, Lianyungang, Jiangsu, 222047, China. Electronic address: .
Cao Z; State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang, Jiangsu, 222001, China; The Key Laboratory for the New Technique Research of TCM Extraction and Purification, Lianyungang, Jiangsu, 222047, China. Electronic address: .
Zhang X; State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang, Jiangsu, 222001, China; The Key Laboratory for the New Technique Research of TCM Extraction and Purification, Lianyungang, Jiangsu, 222047, China. Electronic address: .
Zhou W; Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China. Electronic address: .
Zhang J; Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China. Electronic address: .
Li J; Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China. Electronic address: .
Wu J; Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China. Electronic address: .
Xiao W; State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang, Jiangsu, 222001, China; The Key Laboratory for the New Technique Research of TCM Extraction and Purification, Lianyungang, Jiangsu, 222047, China. Electronic address: .; Pokaż więcej
Źródło :: Journal of ethnopharmacology [J Ethnopharmacol] 2021 Jun 12; Vol. 273, pp. 113871. Date of Electronic Publication: 2021 Jan 22.
Typ publikacji :: Journal Article
MeSH Terms :: Antiviral Agents/*pharmacology
Antiviral Agents/*therapeutic use
COVID-19/*drug therapy
Drugs, Chinese Herbal/*pharmacology
Drugs, Chinese Herbal/*therapeutic use
Angiotensin-Converting Enzyme 2/metabolism ; Animals ; Antiviral Agents/chemistry ; Antiviral Agents/toxicity ; Cell Line, Transformed ; Chlorocebus aethiops ; Computational Biology ; Coronavirus 3C Proteases/metabolism ; Coronavirus Papain-Like Proteases/metabolism ; Cytokines/metabolism ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/toxicity ; Humans ; Medicine, Chinese Traditional/methods ; Molecular Docking Simulation ; Protein Array Analysis ; SARS-CoV-2/drug effects ; Signal Transduction/drug effects ; Vero Cells
SCR Protocol :: COVID-19 drug treatment
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 2 2.

Tytuł :: Antiviral activities and applications of ribosomally synthesized and post-translationally modified peptides (RiPPs).
Autorzy :: Fu Y; Department of Molecular Genetics, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, 9747 AG, Groningen, The Netherlands.
Jaarsma AH; Department of Molecular Genetics, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, 9747 AG, Groningen, The Netherlands.; Department of Environmental Science, Aarhus University, 4000, Roskilde, Denmark.
Kuipers OP; Department of Molecular Genetics, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, 9747 AG, Groningen, The Netherlands. .; Pokaż więcej
Źródło :: Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2021 Apr; Vol. 78 (8), pp. 3921-3940. Date of Electronic Publication: 2021 Feb 02.
Typ publikacji :: Journal Article; Review
MeSH Terms :: Drug Discovery*
Protein Processing, Post-Translational*
Antiviral Agents/*chemistry
Antiviral Agents/*pharmacology
Peptides/*chemistry
Peptides/*pharmacology
Animals ; Antiviral Agents/administration & dosage ; Antiviral Agents/metabolism ; Drug Delivery Systems ; Humans ; Peptides/administration & dosage ; Peptides/metabolism ; Ribosomes/metabolism ; Virus Diseases/drug therapy ; Viruses/drug effects
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 3 3.

Tytuł :: Exploitation of polyphenols and proteins using nanoencapsulation for anti-viral and brain boosting properties - Evoking a synergistic strategy to combat COVID-19 pandemic.
Autorzy :: Noor N; Laboratory of Functional Food and Nutraceuticals, Department of Food Science and Technology, University of Kashmir, Srinagar 190006, India.
Gani A; Laboratory of Functional Food and Nutraceuticals, Department of Food Science and Technology, University of Kashmir, Srinagar 190006, India; Department of Food Science, Rutgers University, 65 Dudley Road, New Brunswick, NJ 08901, United States. Electronic address: .
Gani A; Laboratory of Functional Food and Nutraceuticals, Department of Food Science and Technology, University of Kashmir, Srinagar 190006, India.
Shah A; Laboratory of Functional Food and Nutraceuticals, Department of Food Science and Technology, University of Kashmir, Srinagar 190006, India.
Ashraf ZU; Laboratory of Functional Food and Nutraceuticals, Department of Food Science and Technology, University of Kashmir, Srinagar 190006, India.; Pokaż więcej
Źródło :: International journal of biological macromolecules [Int J Biol Macromol] 2021 Jun 01; Vol. 180, pp. 375-384. Date of Electronic Publication: 2021 Mar 11.
Typ publikacji :: Journal Article; Review
MeSH Terms :: Antiviral Agents*/chemistry
Antiviral Agents*/therapeutic use
COVID-19*/epidemiology
Mental Health*
Nanocapsules*/chemistry
Nanocapsules*/therapeutic use
Pandemics*
Polyphenols*/chemistry
Polyphenols*/therapeutic use
SARS-CoV-2*
Humans
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 4 4.

Tytuł :: Integrative web-based analysis of omics data for study of drugs against SARS-CoV-2.
Autorzy :: Wang Z; Department of Biomedical Engineering, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, 100005, China.
He Y; Unit for Laboratory Animal Medicine, Department of Microbiology and Immunology, Center for Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, MI, 48105, USA.
Huang J; Department of Respiratory and Critical Care Medicine, Chongqing General Hospital, University of Chinese Academy of Sciences, Chongqing, 400014, China.
Yang X; Department of Biomedical Engineering, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, 100005, China. .; Pokaż więcej
Źródło :: Scientific reports [Sci Rep] 2021 May 24; Vol. 11 (1), pp. 10763. Date of Electronic Publication: 2021 May 24.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: User-Computer Interface*
Antiviral Agents/*therapeutic use
COVID-19/*drug therapy
Angiotensin-Converting Enzyme 2/chemistry ; Angiotensin-Converting Enzyme 2/metabolism ; Antiviral Agents/chemistry ; Antiviral Agents/metabolism ; Antiviral Agents/pharmacology ; COVID-19/metabolism ; COVID-19/pathology ; COVID-19/virology ; Cell Line ; Chloroquine/pharmacology ; Gene Expression Regulation/drug effects ; Humans ; Internet ; Protein Binding ; Pyrazoles/pharmacology ; Severity of Illness Index
: Czasopismo naukowe

Szczegóły Pełny tekst

Skocz do pozycji: 5 5.

Tytuł :: Attacking COVID-19 Progression Using Multi-Drug Therapy for Synergetic Target Engagement.
Autorzy :: Coban MA; Department of Cancer Biology, Mayo Clinic, 4500 San Pablo Road South, Jacksonville, FL 32224, USA.
Morrison J; Department of Microbiology and Plant Pathology, University of California, 900 University, Riverside, CA 92521, USA.
Maharjan S; Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 65 Landsdowne St, Cambridge, MA 02139, USA.
Hernandez Medina DH; Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 65 Landsdowne St, Cambridge, MA 02139, USA.
Li W; Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 65 Landsdowne St, Cambridge, MA 02139, USA.
Zhang YS; Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 65 Landsdowne St, Cambridge, MA 02139, USA.
Freeman WD; Department of Neurology, Mayo Clinic, 4500 San Pablo South, Jacksonville, FL 32224, USA.
Radisky ES; Department of Cancer Biology, Mayo Clinic, 4500 San Pablo Road South, Jacksonville, FL 32224, USA.
Le Roch KG; Department of Molecular, Cell and Systems Biology, University of California, 900 University, Riverside, CA 92521, USA.
Weisend CM; Department of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Ebihara H; Department of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Caulfield TR; Department of Cancer Biology, Mayo Clinic, 4500 San Pablo Road South, Jacksonville, FL 32224, USA.; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.; Department of Quantitative Health Science, Division of Computational Biology, Mayo Clinic, Jacksonville, FL 32224, USA.; Department of Clinical Genomics, Mayo Clinic, Rochester, MN 55905, USA.; Department of Biochemistry & Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA.; Pokaż więcej
Źródło :: Biomolecules [Biomolecules] 2021 May 23; Vol. 11 (6). Date of Electronic Publication: 2021 May 23.
Typ publikacji :: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :: Antiviral Agents/*therapeutic use
COVID-19/*drug therapy
Angiotensin-Converting Enzyme 2/chemistry ; Angiotensin-Converting Enzyme 2/metabolism ; Antiviral Agents/chemistry ; Antiviral Agents/metabolism ; Antiviral Agents/pharmacology ; Binding Sites ; COVID-19/pathology ; COVID-19/virology ; Drug Discovery ; Drug Repositioning ; Humans ; Machine Learning ; Molecular Docking Simulation ; SARS-CoV-2/drug effects ; SARS-CoV-2/isolation & purification ; SARS-CoV-2/metabolism ; Serine Endopeptidases/chemistry ; Serine Endopeptidases/metabolism ; Viral Envelope Proteins/antagonists & inhibitors ; Viral Envelope Proteins/metabolism ; Virus Replication/drug effects
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 6 6.

Tytuł :: SARS-CoV-2 main protease inhibition by compounds isolated from Luffa cylindrica using molecular docking.
Autorzy :: Cao TQ; College of Pharmacy, Drug Research and Development Center, Daegu Catholic University, Gyeongbuk 38430, Republic of Korea; Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan 54538, Republic of Korea.
Kim JA; College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu 41566, Republic of Korea.
Woo MH; College of Pharmacy, Drug Research and Development Center, Daegu Catholic University, Gyeongbuk 38430, Republic of Korea.
Min BS; College of Pharmacy, Drug Research and Development Center, Daegu Catholic University, Gyeongbuk 38430, Republic of Korea. Electronic address: .; Pokaż więcej
Źródło :: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2021 May 15; Vol. 40, pp. 127972. Date of Electronic Publication: 2021 Mar 19.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Antiviral Agents/*metabolism
Coronavirus 3C Proteases/*metabolism
Cysteine Proteinase Inhibitors/*metabolism
Luffa/*chemistry
SARS-CoV-2/*drug effects
Saponins/*metabolism
Antiviral Agents/chemistry ; Antiviral Agents/isolation & purification ; Catalytic Domain ; Coronavirus 3C Proteases/chemistry ; Cysteine Proteinase Inhibitors/chemistry ; Cysteine Proteinase Inhibitors/isolation & purification ; Fruit/chemistry ; Molecular Docking Simulation ; Protein Binding ; Saponins/chemistry ; Saponins/isolation & purification
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 7 7.

Tytuł :: Application of niclosamide and analogs as small molecule inhibitors of Zika virus and SARS-CoV-2 infection.
Autorzy :: Shamim K; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3370, USA. Electronic address: .
Xu M; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3370, USA.
Hu X; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3370, USA.
Lee EM; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3370, USA; Department of Biological Science, Florida State University, Tallahassee, FL 32306, USA.
Lu X; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3370, USA.
Huang R; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3370, USA.
Shah P; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3370, USA.
Xu X; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3370, USA.
Chen CZ; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3370, USA.
Shen M; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3370, USA.
Guo H; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3370, USA.
Chen L; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3370, USA.
Itkin Z; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3370, USA.
Eastman RT; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3370, USA.
Shinn P; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3370, USA.
Klumpp-Thomas C; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3370, USA.
Michael S; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3370, USA.
Simeonov A; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3370, USA.
Lo DC; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3370, USA.
Ming GL; Department of Neuroscience and Mahoney Institute for Neurosciences, University of Pennsylvania, Philadelphia, PA 19104, USA.
Song H; Department of Neuroscience and Mahoney Institute for Neurosciences, University of Pennsylvania, Philadelphia, PA 19104, USA.
Tang H; Department of Biological Science, Florida State University, Tallahassee, FL 32306, USA.
Zheng W; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3370, USA.
Huang W; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3370, USA. Electronic address: .; Pokaż więcej
Źródło :: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2021 May 15; Vol. 40, pp. 127906. Date of Electronic Publication: 2021 Mar 06.
Typ publikacji :: Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :: Antiviral Agents/*pharmacology
Niclosamide/*analogs & derivatives
Niclosamide/*pharmacology
SARS-CoV-2/*drug effects
Zika Virus/*drug effects
Animals ; Antiviral Agents/chemical synthesis ; Antiviral Agents/metabolism ; Binding Sites ; Chlorocebus aethiops ; Drug Stability ; Humans ; Microbial Sensitivity Tests ; Microsomes, Liver/metabolism ; Molecular Docking Simulation ; Molecular Structure ; Niclosamide/metabolism ; Protein Binding ; Rats ; Serine Endopeptidases/chemistry ; Serine Endopeptidases/metabolism ; Structure-Activity Relationship ; Vero Cells ; Viral Nonstructural Proteins/chemistry ; Viral Nonstructural Proteins/metabolism ; Viral Proteins/chemistry ; Viral Proteins/metabolism
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 8 8.

Tytuł :: Betulonic Acid Derivatives Interfering with Human Coronavirus 229E Replication via the nsp15 Endoribonuclease.
Autorzy :: Stevaert A; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven, 3000 Leuven, Belgium.
Krasniqi B; Molecular Design and Synthesis, Department of Chemistry, KU Leuven, 3001 Leuven, Belgium.
Van Loy B; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven, 3000 Leuven, Belgium.
Nguyen T; Biochemistry, Molecular and Structural Biology, Department of Chemistry, KU Leuven, 3001 Leuven, Belgium.
Thomas J; Molecular Design and Synthesis, Department of Chemistry, KU Leuven, 3001 Leuven, Belgium.
Vandeput J; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven, 3000 Leuven, Belgium.
Jochmans D; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven, 3000 Leuven, Belgium.
Thiel V; Institute of Virology and Immunology (IVI), 3012 Bern and 3012 Bern, Switzerland.; Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, 3012 Bern, Switzerland.
Dijkman R; Institute of Virology and Immunology (IVI), 3012 Bern and 3012 Bern, Switzerland.; Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, 3012 Bern, Switzerland.; Institute for Infectious Diseases (IFIK), University of Bern, 3012 Bern, Switzerland.
Dehaen W; Molecular Design and Synthesis, Department of Chemistry, KU Leuven, 3001 Leuven, Belgium.
Voet A; Biochemistry, Molecular and Structural Biology, Department of Chemistry, KU Leuven, 3001 Leuven, Belgium.
Naesens L; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven, 3000 Leuven, Belgium.; Pokaż więcej
Źródło :: Journal of medicinal chemistry [J Med Chem] 2021 May 13; Vol. 64 (9), pp. 5632-5644. Date of Electronic Publication: 2021 Apr 20.
Typ publikacji :: Journal Article
MeSH Terms :: Antiviral Agents/*pharmacology
Coronavirus 229E, Human/*drug effects
Coronavirus 229E, Human/*enzymology
Endoribonucleases/*antagonists & inhibitors
Enzyme Inhibitors/*pharmacology
Oleanolic Acid/*analogs & derivatives
Viral Nonstructural Proteins/*antagonists & inhibitors
Virus Replication/*drug effects
Antiviral Agents/chemical synthesis ; Antiviral Agents/chemistry ; Cell Line ; Dose-Response Relationship, Drug ; Endoribonucleases/metabolism ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry ; Humans ; Microbial Sensitivity Tests ; Models, Molecular ; Oleanolic Acid/chemical synthesis ; Oleanolic Acid/chemistry ; Oleanolic Acid/pharmacology ; Viral Nonstructural Proteins/metabolism
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 9 9.

Tytuł :: Potential effect of Maxing Shigan decoction against coronavirus disease 2019 (COVID-19) revealed by network pharmacology and experimental verification.
Autorzy :: Li Y; School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Liangxiang University Town, Fangshan District, Beijing, 102488, China; Dongzhimen Hospital, Beijing University of Chinese Medicine, Dongcheng District, Hai Yun Cang on the 5th, Beijing, 100700, China.
Chu F; School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Liangxiang University Town, Fangshan District, Beijing, 102488, China; Institute of Regulatory Science for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Liangxiang University Town, Fangshan District, Beijing, 102488, China.
Li P; Dongzhimen Hospital, Beijing University of Chinese Medicine, Dongcheng District, Hai Yun Cang on the 5th, Beijing, 100700, China.
Johnson N; International School, Beijing University of Chinese Medicine, No. 11, Bei San Huan Dong Lu, Chaoyang District, Beijing, 100029, China.
Li T; Dongzhimen Hospital, Beijing University of Chinese Medicine, Dongcheng District, Hai Yun Cang on the 5th, Beijing, 100700, China.
Wang Y; School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Liangxiang University Town, Fangshan District, Beijing, 102488, China.
An R; Dongzhimen Hospital, Beijing University of Chinese Medicine, Dongcheng District, Hai Yun Cang on the 5th, Beijing, 100700, China.
Wu D; Dongzhimen Hospital, Beijing University of Chinese Medicine, Dongcheng District, Hai Yun Cang on the 5th, Beijing, 100700, China.
Chen J; School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Liangxiang University Town, Fangshan District, Beijing, 102488, China.
Su Z; School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Liangxiang University Town, Fangshan District, Beijing, 102488, China.
Gu X; School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Liangxiang University Town, Fangshan District, Beijing, 102488, China. Electronic address: .
Ding X; School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Liangxiang University Town, Fangshan District, Beijing, 102488, China. Electronic address: .; Pokaż więcej
Źródło :: Journal of ethnopharmacology [J Ethnopharmacol] 2021 May 10; Vol. 271, pp. 113854. Date of Electronic Publication: 2021 Jan 26.
Typ publikacji :: Journal Article
MeSH Terms :: Alveolar Epithelial Cells/*drug effects
Anti-Inflammatory Agents/*pharmacology
Antiviral Agents/*pharmacology
COVID-19/*drug therapy
Drugs, Chinese Herbal/*pharmacology
Alveolar Epithelial Cells/immunology ; Angiotensin-Converting Enzyme 2/antagonists & inhibitors ; Angiotensin-Converting Enzyme 2/metabolism ; Animals ; Anti-Inflammatory Agents/chemistry ; Anti-Inflammatory Agents/therapeutic use ; Antiviral Agents/chemistry ; Antiviral Agents/therapeutic use ; COVID-19/immunology ; COVID-19/virology ; Cell Line ; Computational Biology ; Coronavirus 3C Proteases/antagonists & inhibitors ; Coronavirus 3C Proteases/metabolism ; Drug Evaluation, Preclinical ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/therapeutic use ; Humans ; Interleukin-6/immunology ; Janus Kinases/metabolism ; Medicine, Chinese Traditional/methods ; Molecular Docking Simulation ; Phosphorylation/drug effects ; Protein Interaction Maps/drug effects ; RNA-Dependent RNA Polymerase/antagonists & inhibitors ; RNA-Dependent RNA Polymerase/metabolism ; Rats ; SARS-CoV-2/immunology ; STAT Transcription Factors/metabolism ; Signal Transduction/drug effects ; Signal Transduction/immunology
SCR Protocol :: COVID-19 drug treatment
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 10 10.

Tytuł :: Emergent Drug and Nutrition Interactions in COVID-19: A Comprehensive Narrative Review.
Autorzy :: Ağagündüz D; Department of Nutrition and Dietetics, Faculty of Health Sciences, Gazi University, Emek, Ankara 06490, Turkey.
Çelik MN; Department of Nutrition and Dietetics, Faculty of Health Sciences, Gazi University, Emek, Ankara 06490, Turkey.
Çıtar Dazıroğlu ME; Department of Nutrition and Dietetics, Faculty of Health Sciences, Gazi University, Emek, Ankara 06490, Turkey.
Capasso R; Department of Agricultural Sciences, University of Naples Federico II, 80055 Naples, Italy.; Pokaż więcej
Źródło :: Nutrients [Nutrients] 2021 May 04; Vol. 13 (5). Date of Electronic Publication: 2021 May 04.
Typ publikacji :: Journal Article; Review
MeSH Terms :: Antiviral Agents*/pharmacokinetics
Antiviral Agents*/therapeutic use
Food-Drug Interactions*
SARS-CoV-2*
COVID-19/*drug therapy
Age Factors ; COVID-19/epidemiology ; Humans
SCR Protocol :: COVID-19 drug treatment
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 11 11.

Tytuł :: Potential "biopeptidal" therapeutics for severe respiratory syndrome coronaviruses: a review of antiviral peptides, viral mechanisms, and prospective needs.
Autorzy :: Ashaolu TJ; Institute of Research and Development, Duy Tan University, Da Nang, 550000, Vietnam.; Faculty of Environmental and Chemical Engineering, Duy Tan University, Da Nang, 550000, Vietnam.
Nawaz A; Jiangsu Key Laboratory of Crop Genetics and Physiology, Key Laboratory of Plant Functional Genomics of the Ministry of Education, College of Agriculture, Yangzhou University, Yangzhou, People's Republic of China.
Walayat N; Department of Food Science and Engineering, College of Ocean, Zhejiang University of Technology, Hangzhou, People's Republic of China.
Khalifa I; Food Technology Department, Faculty of Agriculture, Banha University, 13736, Moshtohor, Cairo, Egypt. .; Pokaż więcej
Źródło :: Applied microbiology and biotechnology [Appl Microbiol Biotechnol] 2021 May; Vol. 105 (9), pp. 3457-3470. Date of Electronic Publication: 2021 Apr 19.
Typ publikacji :: Journal Article; Review
MeSH Terms :: Antiviral Agents*/pharmacology
Antiviral Agents*/therapeutic use
COVID-19*
Animals ; Humans ; Peptides ; Prospective Studies ; SARS-CoV-2
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 12 12.

Tytuł :: RECOVERY 1 year on: a rare success in the COVID-19 clinical trial landscape.
Autorzy :: Mullard A; Pokaż więcej
Źródło :: Nature reviews. Drug discovery [Nat Rev Drug Discov] 2021 May; Vol. 20 (5), pp. 336-337.
Typ publikacji :: Wiadomości
MeSH Terms :: Antiviral Agents*/classification
Antiviral Agents*/pharmacology
Clinical Trials as Topic*/methods
Clinical Trials as Topic*/organization & administration
Clinical Trials as Topic*/standards
COVID-19/*drug therapy
COVID-19/epidemiology ; Clinical Protocols ; Communicable Diseases, Emerging/therapy ; Humans ; Research Design/standards ; SARS-CoV-2 ; Treatment Outcome ; United Kingdom
SCR Protocol :: COVID-19 drug treatment
: Periodyk

Szczegóły

Skocz do pozycji: 13 13.

Tytuł :: Clofazimine broadly inhibits coronaviruses including SARS-CoV-2.
Autorzy :: Yuan S; State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.; Department of Clinical Microbiology and Infection Control, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China.
Yin X; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China.; Immunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Meng X; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Chan JF; State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.; Department of Clinical Microbiology and Infection Control, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China.; Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, Hainan Medical University and The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Ye ZW; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Riva L; Immunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.; Calibr, Scripps Research, La Jolla, CA, USA.
Pache L; Immunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Chan CC; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Lai PM; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Chan CC; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Poon VK; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Lee AC; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Matsunaga N; Immunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Pu Y; Immunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Yuen CK; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Cao J; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Liang R; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Tang K; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Sheng L; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Du Y; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Xu W; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Lau CY; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Sit KY; Department of Surgery, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong SAR, China.
Au WK; Department of Surgery, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong SAR, China.
Wang R; Department of Chemistry, State Key Laboratory of Synthetic Chemistry, CAS-HKU Joint Laboratory of Metallomics on Health and Environment, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Zhang YY; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China.
Tang YD; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China.
Clausen TM; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Copenhagen Center for Glycomics, Department of Molecular and Cellular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Pihl J; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Oh J; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Division of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.
Sze KH; State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Zhang AJ; State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Chu H; State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Kok KH; State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Wang D; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Division of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.
Cai XH; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China.
Esko JD; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Glycobiology Research and Training Center, University of California San Diego, La Jolla, CA, USA.
Hung IF; Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Li RA; Dr Li Dak-Sum Research Centre, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Chen H; State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Sun H; Department of Chemistry, State Key Laboratory of Synthetic Chemistry, CAS-HKU Joint Laboratory of Metallomics on Health and Environment, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Jin DY; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Sun R; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China. .; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA. .
Chanda SK; Immunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA. .
Yuen KY; State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China. .; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China. .; Department of Clinical Microbiology and Infection Control, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China. .; Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, Hainan Medical University and The University of Hong Kong, Pokfulam, Hong Kong SAR, China. .; Pokaż więcej
Źródło :: Nature [Nature] 2021 May; Vol. 593 (7859), pp. 418-423. Date of Electronic Publication: 2021 Mar 16.
Typ publikacji :: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :: Antiviral Agents/*pharmacology
Clofazimine/*pharmacology
Coronavirus/*classification
Coronavirus/*drug effects
SARS-CoV-2/*drug effects
Adenosine Monophosphate/analogs & derivatives ; Adenosine Monophosphate/pharmacology ; Adenosine Monophosphate/therapeutic use ; Alanine/analogs & derivatives ; Alanine/pharmacology ; Alanine/therapeutic use ; Animals ; Anti-Inflammatory Agents/pharmacokinetics ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Antiviral Agents/pharmacokinetics ; Antiviral Agents/therapeutic use ; Biological Availability ; Cell Fusion ; Cell Line ; Clofazimine/pharmacokinetics ; Clofazimine/therapeutic use ; Coronavirus/growth & development ; Coronavirus/pathogenicity ; Cricetinae ; DNA Helicases/antagonists & inhibitors ; Drug Synergism ; Female ; Humans ; Life Cycle Stages/drug effects ; Male ; Mesocricetus ; Pre-Exposure Prophylaxis ; SARS-CoV-2/growth & development ; Species Specificity ; Spike Glycoprotein, Coronavirus/antagonists & inhibitors ; Transcription, Genetic/drug effects ; Transcription, Genetic/genetics
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 14 14.

Tytuł :: Emetine suppresses SARS-CoV-2 replication by inhibiting interaction of viral mRNA with eIF4E.
Autorzy :: Kumar R; National Centre for Veterinary Type Cultures, ICAR-National Research Centre on Equines, Hisar, India.
Afsar M; Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bengaluru, India.
Khandelwal N; National Centre for Veterinary Type Cultures, ICAR-National Research Centre on Equines, Hisar, India.
Chander Y; National Centre for Veterinary Type Cultures, ICAR-National Research Centre on Equines, Hisar, India.
Riyesh T; National Centre for Veterinary Type Cultures, ICAR-National Research Centre on Equines, Hisar, India.
Dedar RK; National Centre for Veterinary Type Cultures, ICAR-National Research Centre on Equines, Hisar, India.
Gulati BR; National Centre for Veterinary Type Cultures, ICAR-National Research Centre on Equines, Hisar, India.
Pal Y; National Centre for Veterinary Type Cultures, ICAR-National Research Centre on Equines, Hisar, India.
Barua S; National Centre for Veterinary Type Cultures, ICAR-National Research Centre on Equines, Hisar, India.
Tripathi BN; National Centre for Veterinary Type Cultures, ICAR-National Research Centre on Equines, Hisar, India. Electronic address: .
Hussain T; Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bengaluru, India. Electronic address: .
Kumar N; National Centre for Veterinary Type Cultures, ICAR-National Research Centre on Equines, Hisar, India. Electronic address: .; Pokaż więcej
Źródło :: Antiviral research [Antiviral Res] 2021 May; Vol. 189, pp. 105056. Date of Electronic Publication: 2021 Mar 10.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Antiviral Agents*/pharmacology
Antiviral Agents*/therapeutic use
Emetine*/pharmacology
Emetine*/therapeutic use
Infectious bronchitis virus/*drug effects
RNA, Viral/*metabolism
SARS-CoV-2/*drug effects
Animals ; Chick Embryo ; Chlorocebus aethiops ; Coronavirus Infections/drug therapy ; Eukaryotic Initiation Factor-4E/metabolism ; Protein Binding/drug effects ; RNA, Messenger/metabolism ; Signal Transduction ; Vero Cells
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 15 15.

Tytuł :: Design, synthesis and biological evaluation of 2-aminoquinazolin-4(3H)-one derivatives as potential SARS-CoV-2 and MERS-CoV treatments.
Autorzy :: Lee JY; Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea.
Shin YS; Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea.
Jeon S; Zoonotic Virus Laboratory, Institut Pasteur Korea, Seongnam-si, Gyeonggi-do 13488, South Korea.
Lee SI; Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea.
Noh S; Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea.
Cho JE; Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea.
Jang MS; Department of Non-Clinical Studies, Korea Institute of Toxicology, Yuseong-gu, Daejeon 34114, South Korea.
Kim S; Zoonotic Virus Laboratory, Institut Pasteur Korea, Seongnam-si, Gyeonggi-do 13488, South Korea.
Song JH; Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea.
Kim HR; Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea.
Park CM; Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea; Korea University of Science and Technology, Daejeon 34114, South Korea. Electronic address: .; Pokaż więcej
Źródło :: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2021 May 01; Vol. 39, pp. 127885. Date of Electronic Publication: 2021 Mar 02.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Drug Design*
Antiviral Agents/*chemical synthesis
Middle East Respiratory Syndrome Coronavirus/*drug effects
Quinazolinones/*pharmacology
SARS-CoV-2/*drug effects
Animals ; Antiviral Agents/pharmacokinetics ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; COVID-19/drug therapy ; COVID-19/virology ; Cell Line ; Cell Survival/drug effects ; Coronavirus Infections/drug therapy ; Coronavirus Infections/virology ; Cytochrome P-450 Enzyme System/chemistry ; Cytochrome P-450 Enzyme System/metabolism ; Half-Life ; Humans ; Inhibitory Concentration 50 ; Mice ; Microsomes/metabolism ; Middle East Respiratory Syndrome Coronavirus/isolation & purification ; Quinazolinones/chemistry ; Quinazolinones/metabolism ; Quinazolinones/therapeutic use ; Rats ; SARS-CoV-2/isolation & purification ; Structure-Activity Relationship
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 16 16.

Tytuł :: Screening and evaluation of anti-SARS-CoV-2 components from Ephedra sinica by ACE2/CMC-HPLC-IT-TOF-MS approach.
Autorzy :: Lv Y; School of Pharmacy, Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China.; Institute of Pharmaceutical Science and Technology, Western China Science & Technology Innovation Harbour, Xi'an, 710115, Shaanxi, China.
Wang S; School of Pharmacy, Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China.; Institute of Pharmaceutical Science and Technology, Western China Science & Technology Innovation Harbour, Xi'an, 710115, Shaanxi, China.
Liang P; School of Pharmacy, Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China.; Institute of Pharmaceutical Science and Technology, Western China Science & Technology Innovation Harbour, Xi'an, 710115, Shaanxi, China.
Wang Y; School of Pharmacy, Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China.; Institute of Pharmaceutical Science and Technology, Western China Science & Technology Innovation Harbour, Xi'an, 710115, Shaanxi, China.
Zhang X; School of Pharmacy, Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China.; Institute of Pharmaceutical Science and Technology, Western China Science & Technology Innovation Harbour, Xi'an, 710115, Shaanxi, China.
Jia Q; School of Pharmacy, Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China.; Institute of Pharmaceutical Science and Technology, Western China Science & Technology Innovation Harbour, Xi'an, 710115, Shaanxi, China.
Fu J; School of Pharmacy, Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China.; Institute of Pharmaceutical Science and Technology, Western China Science & Technology Innovation Harbour, Xi'an, 710115, Shaanxi, China.
Han S; School of Pharmacy, Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China. .; Institute of Pharmaceutical Science and Technology, Western China Science & Technology Innovation Harbour, Xi'an, 710115, Shaanxi, China. .
He L; School of Pharmacy, Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China.; Institute of Pharmaceutical Science and Technology, Western China Science & Technology Innovation Harbour, Xi'an, 710115, Shaanxi, China.; Pokaż więcej
Źródło :: Analytical and bioanalytical chemistry [Anal Bioanal Chem] 2021 May; Vol. 413 (11), pp. 2995-3004. Date of Electronic Publication: 2021 Feb 19.
Typ publikacji :: Journal Article
MeSH Terms :: Ephedra sinica*/chemistry
Angiotensin-Converting Enzyme 2/*metabolism
Antiviral Agents/*pharmacology
COVID-19/*drug therapy
Drugs, Chinese Herbal/*pharmacology
SARS-CoV-2/*drug effects
Antiviral Agents/chemistry ; Antiviral Agents/isolation & purification ; COVID-19/metabolism ; China ; Chromatography, High Pressure Liquid ; Drug Discovery ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/isolation & purification ; Ephedrine/analogs & derivatives ; Ephedrine/isolation & purification ; Ephedrine/pharmacology ; HEK293 Cells ; Humans ; Mass Spectrometry ; Molecular Docking Simulation ; SARS-CoV-2/physiology ; Virus Internalization/drug effects
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 17 17.

Tytuł :: Volatile organic compounds profile synthesized and released by endophytes of tomato (Solanum lycopersici L.) and their antagonistic role.
Autorzy :: López SMY; Centro de Investigaciones en Fitopatología (CIDEFI), La Plata, Argentina. .; Comisión de Investigaciones Científicas de La Provincia de Buenos Aires (CICBA), La Plata, Argentina. .
Pastorino GN; Cátedra de Microbiología Agrícola, Universidad Nacional de La Plata (UNLP), Calle 60 y 119, La Plata, C. P. 1900, Buenos Aires, Argentina.
Balatti PA; Centro de Investigaciones en Fitopatología (CIDEFI), La Plata, Argentina.; Comisión de Investigaciones Científicas de La Provincia de Buenos Aires (CICBA), La Plata, Argentina.; Cátedra de Microbiología Agrícola, Universidad Nacional de La Plata (UNLP), Calle 60 y 119, La Plata, C. P. 1900, Buenos Aires, Argentina.; Pokaż więcej
Źródło :: Archives of microbiology [Arch Microbiol] 2021 May; Vol. 203 (4), pp. 1383-1397. Date of Electronic Publication: 2021 Jan 02.
Typ publikacji :: Journal Article
MeSH Terms :: Antiviral Agents/*pharmacology
Bacteria/*metabolism
Endophytes/*metabolism
Lycopersicon esculentum/*microbiology
Volatile Organic Compounds/*pharmacology
Antibiosis ; Antiviral Agents/isolation & purification ; Antiviral Agents/metabolism ; Bacteria/classification ; Bacteria/isolation & purification ; Endophytes/classification ; Endophytes/isolation & purification ; Fungi/drug effects ; Fungi/growth & development ; Pest Control, Biological ; Plant Diseases/microbiology ; Plant Diseases/prevention & control ; Volatile Organic Compounds/isolation & purification ; Volatile Organic Compounds/metabolism
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 18 18.

Tytuł :: Development of a Physiologically-Based Pharmacokinetic (PBPK) Model of Nebulized Hydroxychloroquine for Pulmonary Delivery to COVID-19 Patients.
Autorzy :: Idkaidek N; College of Pharmacy, University of Petra, Amman, Jordan.
Hawari F; Section of Pulmonary and Critical Care, Department of Internal Medicine, King Hussein Cancer Center and University of Jordan, Amman, Jordan.; Cancer Control Office, King Hussein Cancer Center, Amman, Jordan.
Dodin Y; Cancer Control Office, King Hussein Cancer Center, Amman, Jordan.
Obeidat N; Cancer Control Office, King Hussein Cancer Center, Amman, Jordan.; Pokaż więcej
Źródło :: Drug research [Drug Res (Stuttg)] 2021 May; Vol. 71 (5), pp. 250-256. Date of Electronic Publication: 2020 Dec 30.
Typ publikacji :: Journal Article
MeSH Terms :: Models, Biological*
Antiviral Agents/*pharmacokinetics
COVID-19/*drug therapy
Hydroxychloroquine/*pharmacokinetics
Lung/*metabolism
Administration, Inhalation ; Antiviral Agents/administration & dosage ; Antiviral Agents/blood ; Humans ; Hydroxychloroquine/administration & dosage ; Hydroxychloroquine/blood ; Lung/drug effects ; Nebulizers and Vaporizers ; Tissue Distribution
SCR Protocol :: COVID-19 drug treatment
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 19 19.

Tytuł :: Effective drugs used to combat SARS-CoV-2 infection and the current status of vaccines.
Autorzy :: Awadasseid A; Lab of Chemical Biology and Molecular Drug Design, College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014, China; Department of Biochemistry & Food Sciences, University of Kordofan, El-Obeid, 51111, Sudan.
Wu Y; Lab of Molecular Immunology, Virus Inspection Department, Zhejiang Provincial Center for Disease Control and Prevention, 630 Xincheng Road, Hangzhou, 310051, China. Electronic address: .
Tanaka Y; Center for Medical Innovation, Nagasaki University, 1-7-1 Sakamoto, Nagasaki, 852-8588, Japan.
Zhang W; Lab of Chemical Biology and Molecular Drug Design, College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014, China. Electronic address: .; Pokaż więcej
Źródło :: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2021 May; Vol. 137, pp. 111330. Date of Electronic Publication: 2021 Jan 28.
Typ publikacji :: Journal Article; Review
MeSH Terms :: Antiviral Agents*/classification
Antiviral Agents*/pharmacology
COVID-19*/drug therapy
COVID-19*/prevention & control
COVID-19 Vaccines*/classification
COVID-19 Vaccines*/pharmacology
Humans ; SARS-CoV-2/drug effects ; SARS-CoV-2/physiology ; Treatment Outcome
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 20 20.

Tytuł :: An update review of emerging small-molecule therapeutic options for COVID-19.
Autorzy :: Tian D; School of Life Sciences, Jilin University, Changchun, 130012, PR China.
Liu Y; Faculty of Pharmacy, Shaanxi University of Science & Technology, Xi'an, 710021, PR China.
Liang C; School of Life Sciences, Jilin University, Changchun, 130012, PR China; Faculty of Pharmacy, Shaanxi University of Science & Technology, Xi'an, 710021, PR China. Electronic address: .
Xin L; Faculty of Pharmacy, Shaanxi University of Science & Technology, Xi'an, 710021, PR China.
Xie X; Shaanxi Panlong Pharmaceutical Group Co., Ltd., Xi'an, 710025, PR China.
Zhang D; Shaanxi Panlong Pharmaceutical Group Co., Ltd., Xi'an, 710025, PR China.
Wan M; School of Medicine and Pharmacy, Shaanxi University of Business & Commerce, Xi'an 712046, PR China.
Li H; Faculty of Pharmacy, Shaanxi University of Science & Technology, Xi'an, 710021, PR China.
Fu X; School of Life Sciences, Jilin University, Changchun, 130012, PR China.
Liu H; Zhuhai Jinan Selenium Source Nanotechnology Co., Ltd., Hengqin New Area, Zhuhai, 519030, PR China. Electronic address: .
Cao W; Zhuhai Jinan Selenium Source Nanotechnology Co., Ltd., Hengqin New Area, Zhuhai, 519030, PR China. Electronic address: .; Pokaż więcej
Źródło :: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2021 May; Vol. 137, pp. 111313. Date of Electronic Publication: 2021 Feb 03.
Typ publikacji :: Journal Article; Review
MeSH Terms :: Antiviral Agents*/classification
Antiviral Agents*/pharmacology
COVID-19*/drug therapy
COVID-19*/metabolism
SARS-CoV-2*/drug effects
SARS-CoV-2*/enzymology
Molecular Targeted Therapy/*methods
Enzyme Inhibitors/pharmacology ; Humans ; Therapies, Investigational
: Czasopismo naukowe

Szczegóły

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Antiviral drug types.