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Wyszukujesz frazę ""Apolipoproteins E"" wg kryterium: Temat


Tytuł:
ApoE Isoforms Inhibit Amyloid Aggregation of Proinflammatory Protein S100A9.
Autorzy:
Ghosh S; Department of Medical Biochemistry and Biophysics, Umeå University, SE-90187 Umeå, Sweden.
Tamilselvi S; Department of Medical Biochemistry and Biophysics, Umeå University, SE-90187 Umeå, Sweden.
Williams C; Department of Medical and Translational Biology, Umeå University, SE-90187 Umeå, Sweden.
Jayaweera SW; Department of Clinical Microbiology, Umeå University, SE-90187 Umeå, Sweden.
Iashchishyn IA; Department of Medical Biochemistry and Biophysics, Umeå University, SE-90187 Umeå, Sweden.
Šulskis D; Institute of Biotechnology, Life Sciences Center, Vilnius University, LT-10257 Vilnius, Lithuania.
Gilthorpe JD; Department of Medical and Translational Biology, Umeå University, SE-90187 Umeå, Sweden.
Olofsson A; Department of Clinical Microbiology, Umeå University, SE-90187 Umeå, Sweden.
Smirnovas V; Institute of Biotechnology, Life Sciences Center, Vilnius University, LT-10257 Vilnius, Lithuania.
Svedružić ŽM; Department of Biotechnology, University of Rijeka, HR-51000 Rijeka, Croatia.
Morozova-Roche LA; Department of Medical Biochemistry and Biophysics, Umeå University, SE-90187 Umeå, Sweden.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 09; Vol. 25 (4). Date of Electronic Publication: 2024 Feb 09.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/metabolism
Alzheimer Disease*/pathology
Apolipoprotein E4*/genetics
Apolipoproteins E*/genetics
Calgranulin B*/metabolism
Protein Aggregates*
Humans ; Amyloid ; Amyloid beta-Peptides/metabolism ; Apolipoprotein E3 ; Neuroinflammatory Diseases ; Protein Isoforms/metabolism
Czasopismo naukowe
Tytuł:
Impact of APOE on amyloid and tau accumulation in argyrophilic grain disease and Alzheimer's disease.
Autorzy:
Raulin AC; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.
Doss SV; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.
Heckman MG; Division of Clinical Trials and Biostatistics, Department of Quantitative Health Sciences, Mayo Clinic, Jacksonville, FL, 32224, USA.
Craver EC; Division of Clinical Trials and Biostatistics, Department of Quantitative Health Sciences, Mayo Clinic, Jacksonville, FL, 32224, USA.
Li Z; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.
Ikezu TC; Division of Clinical Trials and Biostatistics, Department of Quantitative Health Sciences, Mayo Clinic, Jacksonville, FL, 32224, USA.
Sekiya H; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.
Liu CC; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.; Biogen, Cambridge, MA, 02142, USA.
Martens YA; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.; SciNeuro Pharmaceuticals, Rockville, MD, 20850, USA.
Rosenberg CL; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.
Kuchenbecker LA; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.
DeTure M; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.
Reichard RR; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, 55905, USA.
Nguyen AT; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, 55905, USA.
Constantopoulos E; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, 55905, USA.
Larsen RA; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, 55905, USA.
Kounaves EK; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, 55905, USA.
Murray ME; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.
Dickson DW; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.
Petersen RC; Department of Neurology, Mayo Clinic, Rochester, MN, 55905, USA.
Bu G; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.; Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.
Kanekiyo T; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA. .
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Źródło:
Acta neuropathologica communications [Acta Neuropathol Commun] 2024 Feb 09; Vol. 12 (1), pp. 25. Date of Electronic Publication: 2024 Feb 09.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/genetics
Alzheimer Disease*/pathology
Apolipoproteins E*/genetics
Tauopathies*/pathology
Humans ; Amyloid ; Amyloid beta-Peptides ; Apolipoprotein E4/genetics ; tau Proteins
Czasopismo naukowe
Tytuł:
Apolipoprotein E isoforms and their Cys-thiol modifications impact LRP1-mediated metabolism of triglyceride-rich lipoproteins.
Autorzy:
Matsuura H; Department of Clinical Laboratory Investigation, Graduate School of Medicine, Shinshu University, Matsumoto, Japan.
Akahane S; Department of Clinical Laboratory Investigation, Graduate School of Medicine, Shinshu University, Matsumoto, Japan.
Kaido T; Department of Clinical Laboratory Investigation, Graduate School of Medicine, Shinshu University, Matsumoto, Japan.; Department of Laboratory Medicine, Shinshu University Hospital, Matsumoto, Japan.
Kamijo T; Department of Clinical Laboratory Investigation, Graduate School of Medicine, Shinshu University, Matsumoto, Japan.; Department of Laboratory Medicine, Shinshu University Hospital, Matsumoto, Japan.
Sakamoto K; Department of Laboratory Medicine, University of Yamanashi Hospital, Japan.
Yamauchi K; Department of Clinical Laboratory Investigation, Graduate School of Medicine, Shinshu University, Matsumoto, Japan.; Department of Biomedical Laboratory Sciences, School of Health Sciences, Shinshu University, Matsumoto, Japan.
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Źródło:
FEBS letters [FEBS Lett] 2024 Feb; Vol. 598 (3), pp. 347-362. Date of Electronic Publication: 2024 Jan 27.
Typ publikacji:
Journal Article
MeSH Terms:
Sulfhydryl Compounds*
Apolipoproteins E*/metabolism
Apolipoprotein E2/metabolism ; Apolipoprotein E3/genetics ; Apolipoprotein E3/metabolism ; Apolipoprotein E4/genetics ; Apolipoprotein E4/metabolism ; Triglycerides/metabolism ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Carrier Proteins
Czasopismo naukowe
Tytuł:
APOE genotype dictates lipidomic signatures in primary human hepatocytes.
Autorzy:
Almeida FC; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal; ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Portugal; Department of Neuroradiology, Centro Hospitalar Universitário do Porto, Porto, Portugal.
Patra K; Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.
Giannisis A; Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.
Niesnerova A; Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.
Nandakumar R; Irving Institute for Clinical and Translational Research, Columbia University Irving Medical Center, New York, USA.
Ellis E; Department of Clinical Science, Intervention and Technology, (CLINTEC), Division of Transplantation surgery, Karolinska Institutet and ME Transplantation, Karolinska University Hospital, Huddinge, Sweden.
Oliveira TG; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal; ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Portugal; Department of Neuroradiology, Hospital de Braga, Braga, Portugal. Electronic address: .
Nielsen HM; Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden. Electronic address: .
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Źródło:
Journal of lipid research [J Lipid Res] 2024 Feb; Vol. 65 (2), pp. 100498. Date of Electronic Publication: 2024 Jan 11.
Typ publikacji:
Journal Article
MeSH Terms:
Apolipoproteins E*/genetics
Lipidomics*
Female ; Humans ; Alleles ; Genotype ; Hepatocytes
Czasopismo naukowe
Tytuł:
Understanding the interplay between APO E polymorphism and cognition in the Italian oldest old: results from the "Mugello study".
Autorzy:
Lombardi G; Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Viale Pieraccini 6, 50139, Florence, Italy.; IRCCS Fondazione Don Carlo Gnocchi Onlus, Via Di Scandicci 269, 50143, Florence, Italy.
Pancani S; IRCCS Fondazione Don Carlo Gnocchi Onlus, Via Di Scandicci 269, 50143, Florence, Italy. .
Bagnoli S; Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Viale Pieraccini 6, 50139, Florence, Italy.; IRCCS Fondazione Don Carlo Gnocchi Onlus, Via Di Scandicci 269, 50143, Florence, Italy.
Vannetti F; IRCCS Fondazione Don Carlo Gnocchi Onlus, Via Di Scandicci 269, 50143, Florence, Italy.
Nacmias B; Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Viale Pieraccini 6, 50139, Florence, Italy.; IRCCS Fondazione Don Carlo Gnocchi Onlus, Via Di Scandicci 269, 50143, Florence, Italy.
Sorbi S; Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Viale Pieraccini 6, 50139, Florence, Italy.; IRCCS Fondazione Don Carlo Gnocchi Onlus, Via Di Scandicci 269, 50143, Florence, Italy.
Cecchi F; IRCCS Fondazione Don Carlo Gnocchi Onlus, Via Di Scandicci 269, 50143, Florence, Italy.; Department of Experimental and Clinical Medicine, University of Florence, Largo Brambilla 3, 50134, Florence, Italy.
Macchi C; IRCCS Fondazione Don Carlo Gnocchi Onlus, Via Di Scandicci 269, 50143, Florence, Italy.; Department of Experimental and Clinical Medicine, University of Florence, Largo Brambilla 3, 50134, Florence, Italy.
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Źródło:
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology [Neurol Sci] 2024 Feb; Vol. 45 (2), pp. 539-546. Date of Electronic Publication: 2023 Sep 15.
Typ publikacji:
Journal Article
MeSH Terms:
Apolipoproteins E*/genetics
Dementia*
Aged ; Aged, 80 and over ; Humans ; Apolipoprotein E4/genetics ; Cognition ; Genotype ; Polymorphism, Genetic/genetics
Czasopismo naukowe
Tytuł:
Alzheimer's disease phenotype based upon the carrier status of the apolipoprotein E ɛ4 allele.
Autorzy:
Ji XY; Department of Neurosurgery, The First Affiliated Hospital of Shantou University Medical College, Guangdong, China.; Brain Function and Disease Laboratory, Shantou University Medical College, Guangdong, China.
Peng XY; Department of Neurosurgery, The First Affiliated Hospital of Shantou University Medical College, Guangdong, China.
Tang HL; Fudan University Huashan Hospital, Department of Neurosurgery, State Key Laboratory for Medical Neurobiology, Institutes of Brain Science, Shanghai Medical College-Fudan University, Shanghai, China.
Pan H; Shantou Longhu People's Hospital, Shantou, Guangdong, China.
Wang WT; Department of Neurosurgery, The First Affiliated Hospital of Shantou University Medical College, Guangdong, China.
Wu J; Department of Neurosurgery, The First Affiliated Hospital of Shantou University Medical College, Guangdong, China.; Brain Function and Disease Laboratory, Shantou University Medical College, Guangdong, China.
Chen J; Department of Neurosurgery, The First Affiliated Hospital of Shantou University Medical College, Guangdong, China.
Wei NL; Department of Neurosurgery, The First Affiliated Hospital of Shantou University Medical College, Guangdong, China.
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Źródło:
Brain pathology (Zurich, Switzerland) [Brain Pathol] 2024 Jan; Vol. 34 (1), pp. e13208. Date of Electronic Publication: 2023 Aug 30.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
Alzheimer Disease*/pathology
Apolipoproteins E*/genetics
Humans ; Alleles ; Apolipoprotein E3/genetics ; Apolipoprotein E4/genetics ; Apolipoprotein E4/metabolism ; Cognition ; Phenotype ; Protein Isoforms/genetics
Czasopismo naukowe
Tytuł:
Perivascular space burden interacts with APOE-ε4 status on cognition in older adults.
Autorzy:
Gogniat MA; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.
Khan OA; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.
Bown CW; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Liu D; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.
Pechman KR; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.
Taylor Davis L; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
Gifford KA; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.
Landman BA; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Electrical and Computer Engineering, Vanderbilt University, Nashville, TN, USA.
Hohman TJ; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.
Jefferson AL; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA; Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address: .
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Źródło:
Neurobiology of aging [Neurobiol Aging] 2024 Apr; Vol. 136, pp. 1-8. Date of Electronic Publication: 2024 Jan 22.
Typ publikacji:
Journal Article
MeSH Terms:
Cognition*
Apolipoproteins E*/genetics
Humans ; Male ; Aged ; Female ; Cross-Sectional Studies ; Genotype ; Apolipoprotein E4/genetics ; Neuropsychological Tests ; Apolipoproteins
Czasopismo naukowe
Tytuł:
Spinal apolipoprotein E is involved in inflammatory pain via regulating lipid metabolism and glial activation in the spinal dorsal horn.
Autorzy:
Liu S; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, People's Republic of China.; Institute of Neuroscience, Translational Medicine Institute, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, People's Republic of China.
Yang S; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, People's Republic of China.; Institute of Neuroscience, Translational Medicine Institute, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, People's Republic of China.
Zhu X; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, People's Republic of China.; Department of Anesthesiology, Central Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, People's Republic of China.
Li X; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, People's Republic of China.; Institute of Neuroscience, Translational Medicine Institute, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, People's Republic of China.
Zhang X; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, People's Republic of China.; Institute of Neuroscience, Translational Medicine Institute, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, People's Republic of China.
Zhou X; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, People's Republic of China.; Institute of Neuroscience, Translational Medicine Institute, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, People's Republic of China.
Cheng H; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, People's Republic of China.; Institute of Neuroscience, Translational Medicine Institute, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, People's Republic of China.
Huo FQ; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, People's Republic of China.; Institute of Neuroscience, Translational Medicine Institute, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, People's Republic of China.; Key Laboratory of Environment and Genes Related to Diseases, Xi'an Jiaotong University, Ministry of Education, Xi'an, Shaanxi, People's Republic of China.
Mao Q; Department of Anesthesiology, Daping Hospital, Army Medical University, Chongqing, People's Republic of China. .
Liang L; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, People's Republic of China. .; Institute of Neuroscience, Translational Medicine Institute, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, People's Republic of China. .; Key Laboratory of Environment and Genes Related to Diseases, Xi'an Jiaotong University, Ministry of Education, Xi'an, Shaanxi, People's Republic of China. .
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Źródło:
Biology direct [Biol Direct] 2023 Dec 09; Vol. 18 (1), pp. 85. Date of Electronic Publication: 2023 Dec 09.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Apolipoproteins E*/genetics
Apolipoproteins E*/metabolism
Hyperalgesia*/chemically induced
Hyperalgesia*/genetics
Hyperalgesia*/metabolism
Lipid Metabolism*
Pain*/chemically induced
Pain*/metabolism
Animals ; Mice ; Freund's Adjuvant/adverse effects ; Inflammation ; Spinal Cord Dorsal Horn/metabolism ; Mice, Knockout, ApoE
Czasopismo naukowe
Tytuł:
Isolation of recombinant apolipoprotein E4 N-terminal domain by foam fractionation.
Autorzy:
Lethcoe K; Department of Biochemistry and Molecular Biology, University of Nevada, Reno, NV, 89557, USA.
Fox CA; Department of Biochemistry and Molecular Biology, University of Nevada, Reno, NV, 89557, USA.
Hafiane A; Department of Medicine, Division of Cardiology, McGill University, Montreal, QC, Canada.
Kiss RS; Department of Medicine, Division of Cardiology, McGill University, Montreal, QC, Canada.
Ryan RO; Department of Biochemistry and Molecular Biology, University of Nevada, Reno, NV, 89557, USA. Electronic address: .
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Źródło:
Protein expression and purification [Protein Expr Purif] 2023 Oct; Vol. 210, pp. 106319. Date of Electronic Publication: 2023 Jun 06.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Apolipoprotein E4*/genetics
Apolipoprotein E4*/metabolism
Apolipoproteins E*/genetics
Apolipoproteins E*/chemistry
Apolipoproteins E*/metabolism
Humans ; Carrier Proteins ; Recombinant Proteins/chemistry
Czasopismo naukowe
Tytuł:
Uncovering the Localization and Function of a Novel Read-Through Transcript ' TOMM40-APOE '.
Autorzy:
Chang S; Department of Pathological Cell Biology, Medical Research Institute, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.; Department of Personalized Genomic Medicine for Health, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.
Torii S; Department of Pathological Cell Biology, Medical Research Institute, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.
Inamo J; Department of Genomic Function and Diversity, Medical Research Institute, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.
Ishikawa K; Department of Personalized Genomic Medicine for Health, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.
Kochi Y; Department of Genomic Function and Diversity, Medical Research Institute, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.
Shimizu S; Department of Pathological Cell Biology, Medical Research Institute, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.
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Źródło:
Cells [Cells] 2023 Dec 28; Vol. 13 (1). Date of Electronic Publication: 2023 Dec 28.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Apolipoprotein E4*
Apolipoproteins E*
Apolipoprotein E3 ; Cell Death ; DNA, Complementary
Czasopismo naukowe
Tytuł:
Correlation between ESR1 and APOE gene polymorphisms and risk of osteonecrosis of the femoral head: a case-control study.
Autorzy:
Wang Y; College of Life Sciences, Northwest University, Xi'an, 710069, Shaanxi, China.; Provincial Key Laboratory of Biotechnology of Shaanxi, Northwest University, Xi'an, 710069, Shaanxi, China.; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Life Sciences, Northwest University, Xi'an, 710069, Shaanxi, China.; Department of Joint Surgery, Affiliated Hospital of Weifang Medical University, Weifang, 261031, Shandong, China.
Ma X; College of Life Sciences, Northwest University, Xi'an, 710069, Shaanxi, China.; Provincial Key Laboratory of Biotechnology of Shaanxi, Northwest University, Xi'an, 710069, Shaanxi, China.; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Life Sciences, Northwest University, Xi'an, 710069, Shaanxi, China.
Guo J; College of Life Sciences, Northwest University, Xi'an, 710069, Shaanxi, China.; Provincial Key Laboratory of Biotechnology of Shaanxi, Northwest University, Xi'an, 710069, Shaanxi, China.; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Life Sciences, Northwest University, Xi'an, 710069, Shaanxi, China.
Li Y; College of Life Sciences, Northwest University, Xi'an, 710069, Shaanxi, China.; Provincial Key Laboratory of Biotechnology of Shaanxi, Northwest University, Xi'an, 710069, Shaanxi, China.; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Life Sciences, Northwest University, Xi'an, 710069, Shaanxi, China.
Xiong Y; College of Life Sciences, Northwest University, Xi'an, 710069, Shaanxi, China. .; Provincial Key Laboratory of Biotechnology of Shaanxi, Northwest University, Xi'an, 710069, Shaanxi, China. .; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Life Sciences, Northwest University, Xi'an, 710069, Shaanxi, China. .
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Źródło:
Journal of orthopaedic surgery and research [J Orthop Surg Res] 2023 Dec 15; Vol. 18 (1), pp. 968. Date of Electronic Publication: 2023 Dec 15.
Typ publikacji:
Journal Article
MeSH Terms:
Apolipoproteins E*/genetics
Femur Head Necrosis*/genetics
Estrogen Receptor alpha*/genetics
Aged ; Humans ; Case-Control Studies ; Femur Head ; Genetic Predisposition to Disease ; Polymorphism, Single Nucleotide
Czasopismo naukowe
Tytuł:
Molecular modeling of apoE in complexes with Alzheimer's amyloid-β fibrils from human brain suggests a structural basis for apolipoprotein co-deposition with amyloids.
Autorzy:
Lewkowicz E; Department of Pharmacology, Physiology & Biophysics, Boston University Chobanian and Avedisian School of Medicine, W302, 700 Albany Street, Boston, MA, 02118, USA.
Nakamura MN; Undergraduate program, Department of Chemistry and Biochemistry, Middlebury College, 14 Old Chapel Rd, Middlebury, VT, 05753, USA.
Rynkiewicz MJ; Department of Pharmacology, Physiology & Biophysics, Boston University Chobanian and Avedisian School of Medicine, W302, 700 Albany Street, Boston, MA, 02118, USA.
Gursky O; Department of Pharmacology, Physiology & Biophysics, Boston University Chobanian and Avedisian School of Medicine, W302, 700 Albany Street, Boston, MA, 02118, USA. .
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Źródło:
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2023 Nov 27; Vol. 80 (12), pp. 376. Date of Electronic Publication: 2023 Nov 27.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/metabolism
Amyloid beta-Peptides*/metabolism
Apolipoproteins E*/metabolism
Humans ; Amyloid/metabolism ; Apolipoproteins/chemistry ; Apolipoproteins/metabolism ; Brain/metabolism ; Cryoelectron Microscopy ; Molecular Dynamics Simulation ; Peptide Fragments/metabolism
Czasopismo naukowe
Tytuł:
Structural flexibility of apolipoprotein E-derived arginine-rich peptides improves their cell penetration capability.
Autorzy:
Takechi-Haraya Y; Division of Drugs, National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-ku, Kawasaki, 210-9501, Japan. .
Ohgita T; Center for Instrumental Analysis, Kyoto Pharmaceutical University, 1 Misasagi-Shichono-cho, Yamashina-ku, Kyoto, 607-8412, Japan.
Usui A; Division of Drugs, National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-ku, Kawasaki, 210-9501, Japan.
Nishitsuji K; Department of Biochemistry, Wakayama Medical University, 811-1 Kimiidera, Wakayama, 641-8509, Japan.; Unité de Glycobiologie Structurale et Fonctionnelle, UMR 8576 CNRS, Université de Lille, 59655, Villeneuve d'Ascq, France.
Uchimura K; Unité de Glycobiologie Structurale et Fonctionnelle, UMR 8576 CNRS, Université de Lille, 59655, Villeneuve d'Ascq, France.
Abe Y; Division of Drugs, National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-ku, Kawasaki, 210-9501, Japan.
Kawano R; Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-6 Naka-cho, Koganei, Tokyo, 184-8588, Japan.
Konaklieva MI; Department of Chemistry, American University, 4400 Massachusetts Avenue NW, Washington, DC, 20016-8014, USA.
Reimund M; Lipoprotein Metabolism Laboratory, Translational Vascular Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Remaley AT; Lipoprotein Metabolism Laboratory, Translational Vascular Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Sato Y; Division of Drugs, National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-ku, Kawasaki, 210-9501, Japan.
Izutsu KI; School of Pharmacy Department of Pharmaceutical Sciences, International University of Health and Welfare, 2600-1 Kitakanemaru, Otawara, Tochigi, 324-8501, Japan.
Saito H; Department of Biophysical Chemistry, Kyoto Pharmaceutical University, 5 Misasagi-Nakauchi-cho, Yamashina-ku, Kyoto, 607-8414, Japan.
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Źródło:
Scientific reports [Sci Rep] 2023 Nov 08; Vol. 13 (1), pp. 19396. Date of Electronic Publication: 2023 Nov 08.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Arginine*
Peptides*/chemistry
Apolipoproteins E*
Cell Membrane ; Circular Dichroism ; Liposomes
Czasopismo naukowe
Tytuł:
Jun-APOE-LRP1 axis promotes tumor metastasis in colorectal cancer.
Autorzy:
He L; Department of Clinical Laboratory, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China; Department of General Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangdong Institute of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Shi M; Department of Clinical Laboratory, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China; Department of General Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangdong Institute of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Ren S; Department of Clinical Laboratory, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China; Department of General Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangdong Institute of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Zhang J; Department of Clinical Laboratory, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China; Department of General Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangdong Institute of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Tian Y; Department of Clinical Laboratory, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China; Department of General Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangdong Institute of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Yang X; Department of Clinical Laboratory, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China; Department of General Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangdong Institute of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Liu H; Department of Clinical Laboratory, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China; Department of General Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangdong Institute of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
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Źródło:
Biomolecules & biomedicine [Biomol Biomed] 2023 Nov 03; Vol. 23 (6), pp. 1026-1037. Date of Electronic Publication: 2023 Nov 03.
Typ publikacji:
Journal Article
MeSH Terms:
Apolipoproteins E*/metabolism
Colorectal Neoplasms*/genetics
Humans ; Low Density Lipoprotein Receptor-Related Protein-1/genetics ; Transcription Factors/metabolism ; Cell Movement/genetics ; Carrier Proteins
Czasopismo naukowe
Tytuł:
Illuminating the full spectrum of APOE variation.
Autorzy:
Hegele RA; Department of Medicine and Robarts Research Institute, Western University, 4288A-1151 Richmond Street North, London, Ontario, N6A 5B7, Canada. Electronic address: .
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Źródło:
Atherosclerosis [Atherosclerosis] 2023 Nov; Vol. 385, pp. 117311. Date of Electronic Publication: 2023 Sep 28.
Typ publikacji:
Editorial; Comment
MeSH Terms:
Apolipoproteins E*/genetics
Opinia redakcyjna
Tytuł:
APOE and vascular disease: Sequencing and genotyping in general population cohorts.
Autorzy:
Rasmussen KL; Department of Clinical Biochemistry, Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen, Denmark; The Copenhagen General Population Study, Herlev and Gentofte Hospital, Herlev Ringvej 75, DK-2730 Herlev, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen, Denmark; Department of Clinical Biochemistry, Nordsjællands Hospital, Dyrehavevej 29, DK-3400 Hillerød, Denmark. Electronic address: .
Luo J; Department of Clinical Biochemistry, Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen, Denmark; The Copenhagen General Population Study, Herlev and Gentofte Hospital, Herlev Ringvej 75, DK-2730 Herlev, Denmark.
Nordestgaard BG; The Copenhagen General Population Study, Herlev and Gentofte Hospital, Herlev Ringvej 75, DK-2730 Herlev, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen, Denmark; The Copenhagen City Heart Study, Frederiksberg Hospital, Nordre Fasanvej 57, DK-2000 Frederiksberg, Denmark; Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Herlev Ringvej 75, DK-2730 Herlev, Denmark.
Tybjærg-Hansen A; Department of Clinical Biochemistry, Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen, Denmark; The Copenhagen General Population Study, Herlev and Gentofte Hospital, Herlev Ringvej 75, DK-2730 Herlev, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen, Denmark; The Copenhagen City Heart Study, Frederiksberg Hospital, Nordre Fasanvej 57, DK-2000 Frederiksberg, Denmark.
Frikke-Schmidt R; Department of Clinical Biochemistry, Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen, Denmark; The Copenhagen General Population Study, Herlev and Gentofte Hospital, Herlev Ringvej 75, DK-2730 Herlev, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen, Denmark.
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Źródło:
Atherosclerosis [Atherosclerosis] 2023 Nov; Vol. 385, pp. 117218. Date of Electronic Publication: 2023 Aug 09.
Typ publikacji:
Meta-Analysis; Journal Article
MeSH Terms:
Apolipoproteins E*/genetics
Vascular Diseases*/genetics
Humans ; Cholesterol ; Genotype ; Myocardial Ischemia/epidemiology ; Triglycerides
Czasopismo naukowe
Tytuł:
The Association between Apolipoprotein E Genotypes and Serum Malondialdehyde Level with End-Stage Renal Disease.
Autorzy:
Pourmand D; Department of Laboratory Sciences, School of Para Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Veisi-Raygani A; Department of Clinical Biochemistry, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Bahrehmand F; Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Asadi S; Department of Laboratory Sciences, School of Para Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
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Źródło:
Iranian journal of medical sciences [Iran J Med Sci] 2023 Jul; Vol. 48 (4), pp. 414-419.
Typ publikacji:
Journal Article
MeSH Terms:
Apolipoproteins E*/genetics
Kidney Failure, Chronic*/genetics
Humans ; Gene Frequency ; Malondialdehyde ; Cross-Sectional Studies ; Genotype
Czasopismo naukowe
Tytuł:
Apolipoprotein E ε2 allele is associated with lower risk of carotid artery obstruction in a population-based autopsy study.
Autorzy:
Paradela RS; Division of Geriatrics, University of Sao Paulo Medical School, Brazil. Electronic address: .
Farias-Itao DS; Department of Pathology, University of Sao Paulo Medical School, Sao Paulo, Brazil.
Leite REP; Department of Pathology, University of Sao Paulo Medical School, Sao Paulo, Brazil.
Pasqualucci CA; Department of Pathology, University of Sao Paulo Medical School, Sao Paulo, Brazil.
Grinberg LT; Department of Pathology, University of Sao Paulo Medical School, Sao Paulo, Brazil; Memory and Aging Center, University of California San Francisco, USA.
Naslavsky MS; Human Genome and Stem Cell Center, Biosciences Institute, University of São Paulo, São Paulo, Brazil.
Zatz M; Human Genome and Stem Cell Center, Biosciences Institute, University of São Paulo, São Paulo, Brazil.
Nitrini R; Department of Neurology, University of São Paulo Medical School, Brazil.
Jacob-Filho W; Division of Geriatrics, University of Sao Paulo Medical School, Brazil.
Suemoto CK; Division of Geriatrics, University of Sao Paulo Medical School, Brazil.
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Źródło:
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association [J Stroke Cerebrovasc Dis] 2023 Sep; Vol. 32 (9), pp. 107229. Date of Electronic Publication: 2023 Jul 31.
Typ publikacji:
Journal Article
MeSH Terms:
Apolipoproteins E*/genetics
Carotid Artery Diseases*/diagnostic imaging
Carotid Artery Diseases*/genetics
Thrombosis*
Aged ; Aged, 80 and over ; Female ; Humans ; Male ; Middle Aged ; Alleles ; Apolipoprotein E2 ; Apolipoprotein E4/genetics ; Autopsy ; Carotid Arteries/diagnostic imaging ; Carotid Intima-Media Thickness ; Constriction, Pathologic ; Cross-Sectional Studies ; Genetic Predisposition to Disease ; Genotype ; Risk Factors
Czasopismo naukowe
Tytuł:
Alzheimer's Disease: Causal Effect between Obesity and APOE Gene Polymorphisms.
Autorzy:
Zhao T; Department of Pharmacology, College of Basic Medical Sciences, Jilin University, 126 Xinmin Street, Changchun 130012, China.
Zhong T; School of Nursing, Jilin University, 965 Xinjiang Street, Changchun 130012, China.
Zhang M; School of Nursing, Jilin University, 965 Xinjiang Street, Changchun 130012, China.
Xu Y; Department of Pharmacology, College of Basic Medical Sciences, Jilin University, 126 Xinmin Street, Changchun 130012, China.
Zhang M; Department of Pharmacology, College of Basic Medical Sciences, Jilin University, 126 Xinmin Street, Changchun 130012, China.
Chen L; Department of Pharmacology, College of Basic Medical Sciences, Jilin University, 126 Xinmin Street, Changchun 130012, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Aug 31; Vol. 24 (17). Date of Electronic Publication: 2023 Aug 31.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/genetics
Apolipoproteins E*/genetics
Humans ; Apolipoprotein E2 ; Apolipoprotein E3 ; Apolipoprotein E4/genetics ; Obesity/complications ; Obesity/genetics ; Polymorphism, Genetic
Czasopismo naukowe
Tytuł:
A polygenic risk score for Alzheimer's disease constructed using APOE-region variants has stronger association than APOE alleles with mild cognitive impairment in Hispanic/Latino adults in the U.S.
Autorzy:
Sofer T; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA. .; Department of Medicine, Harvard Medical School, Boston, MA, USA. .; CardioVascular Institute, Beth Israel Deaconess Medical Center, Boston, MA, USA. .
Kurniansyah N; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.
Granot-Hershkovitz E; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.
Goodman MO; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.
Tarraf W; Institute of Gerontology, Wayne State University, Detroit, MI, USA.
Broce I; Department of Neurosciences, University of California San Diego, San Diego, CA, USA.
Lipton RB; Albert Einstein College of Medicine, Bronx, NY, USA.
Daviglus M; Department of Medicine, Institute for Minority Health Research, University of Illinois at Chicago, Chicago, IL, USA.
Lamar M; Department of Medicine, Institute for Minority Health Research, University of Illinois at Chicago, Chicago, IL, USA.; Rush Alzheimer's Disease Research Center, Rush University Medical Center, Chicago, IL, USA.
Wassertheil-Smoller S; Department of Epidemiology & Population Health, Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY, USA.
Cai J; Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
DeCarli CS; Department of Neurology, University of California at Davis, Sacramento, CA, USA.
Gonzalez HM; Department of Neurosciences, University of California San Diego, San Diego, CA, USA.; Shiley-Marcos Alzheimer's Disease Center, University of California San Diego, La Jolla, CA, USA.
Fornage M; Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX, USA.
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Źródło:
Alzheimer's research & therapy [Alzheimers Res Ther] 2023 Aug 30; Vol. 15 (1), pp. 146. Date of Electronic Publication: 2023 Aug 30.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Alzheimer Disease*/genetics
Apolipoproteins E*/genetics
Cognitive Dysfunction*/genetics
Aged ; Humans ; Middle Aged ; Alleles ; Hispanic or Latino/genetics ; Risk Factors
Czasopismo naukowe

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