Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ

Wyszukujesz frazę ""Apolipoproteins E"" wg kryterium: Temat


Tytuł :
Response to Comment on "ApoE e4e4 Genotype and Mortality With COVID-19 in UK Biobank" by Kuo et al.
Autorzy :
Kuo CL; Connecticut Convergence Institute for Translation in Regenerative Engineering, University of Connecticut Health, Farmington, Connecticut.; Center on Aging, University of Connecticut Health, Farmington, Connecticut.
Melzer D; Center on Aging, University of Connecticut Health, Farmington, Connecticut.; Epidemiology and Public Health Group, University of Exeter Medical School, Exeter, Devon, UK.
Pokaż więcej
Źródło :
The journals of gerontology. Series A, Biological sciences and medical sciences [J Gerontol A Biol Sci Med Sci] 2020 Oct 15; Vol. 75 (11), pp. 2235-2236.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Apolipoproteins E*/genetics
Biological Specimen Banks*
Coronavirus Infections*
Pandemics*
Pneumonia, Viral*
Betacoronavirus ; Genotype ; Humans ; United Kingdom
SCR Disease Name :
COVID-19
Czasopismo naukowe
Tytuł :
Control of the neuroprotective Lipocalin Apolipoprotein D expression by alternative promoter regions and differentially expressed mRNA 5' UTR variants.
Autorzy :
Diez-Hermano S; Departamento de Bioquimica y Biologia Molecular y Fisiologia, Instituto de Biologia y Genetica Molecular, Universidad de Valladolid-CSIC, Valladolid, Spain.; Departamento de Matemática Aplicada, Universidad Complutense, Madrid, Spain.
Mejias A; Departamento de Genetica, Universidad de Sevilla, Sevilla, Spain.
Sanchez D; Departamento de Bioquimica y Biologia Molecular y Fisiologia, Instituto de Biologia y Genetica Molecular, Universidad de Valladolid-CSIC, Valladolid, Spain.
Gutierrez G; Departamento de Genetica, Universidad de Sevilla, Sevilla, Spain.
Ganfornina MD; Departamento de Bioquimica y Biologia Molecular y Fisiologia, Instituto de Biologia y Genetica Molecular, Universidad de Valladolid-CSIC, Valladolid, Spain.
Pokaż więcej
Źródło :
PloS one [PLoS One] 2020 Jun 19; Vol. 15 (6), pp. e0234857. Date of Electronic Publication: 2020 Jun 19 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
5' Untranslated Regions*
Promoter Regions, Genetic*
Apolipoproteins D/*genetics
Apolipoproteins E/*genetics
Animals ; Apolipoproteins D/metabolism ; Apolipoproteins E/metabolism ; Astrocytes/metabolism ; Brain/cytology ; Brain/drug effects ; Brain/metabolism ; Cell Line ; Herbicides/toxicity ; Lipocalins/genetics ; Lipocalins/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mutation ; Oxidative Stress ; Paraquat/toxicity ; RNA, Messenger/genetics ; RNA, Messenger/metabolism
Czasopismo naukowe
Tytuł :
ApoE and mitochondrial dysfunction.
Autorzy :
Qin L; From the Department of Pathology (L.Q., X.Z.), Case Western Reserve University, Cleveland, OH; and Department of Neurology (R.P.F.), University of Louisville, KY.
Zhu X; From the Department of Pathology (L.Q., X.Z.), Case Western Reserve University, Cleveland, OH; and Department of Neurology (R.P.F.), University of Louisville, KY. .
Friedland RP; From the Department of Pathology (L.Q., X.Z.), Case Western Reserve University, Cleveland, OH; and Department of Neurology (R.P.F.), University of Louisville, KY. .
Pokaż więcej
Źródło :
Neurology [Neurology] 2020 Jun 09; Vol. 94 (23), pp. 1009-1010. Date of Electronic Publication: 2020 May 26.
Typ publikacji :
Editorial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Comment
MeSH Terms :
Alzheimer Disease*
Apolipoproteins E*
Humans ; Mitochondria ; Mitochondrial Proteins ; Protein Isoforms
Raport
Tytuł :
Hesperidin blocks varenicline-aggravated atherosclerotic plaque formation in apolipoprotein E knockout mice by downregulating net uptake of oxidized low-density lipoprotein in macrophages.
Autorzy :
Koga M; Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan.
Kanaoka Y; Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan.
Inada K; Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan.
Omine S; Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan.
Kataoka Y; Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan.
Yamauchi A; Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan. Electronic address: .
Pokaż więcej
Źródło :
Journal of pharmacological sciences [J Pharmacol Sci] 2020 Jun; Vol. 143 (2), pp. 106-111. Date of Electronic Publication: 2020 Feb 28.
Typ publikacji :
Journal Article
MeSH Terms :
Apolipoproteins E*
Down-Regulation/*drug effects
Hesperidin/*pharmacology
Lipoproteins, LDL/*metabolism
Macrophages/*metabolism
Plaque, Atherosclerotic/*metabolism
Varenicline/*adverse effects
Varenicline/*antagonists & inhibitors
ATP Binding Cassette Transporter 1/metabolism ; ATP Binding Cassette Transporter, Subfamily G, Member 1/metabolism ; Animals ; CD36 Antigens/metabolism ; Cardiovascular Diseases/chemically induced ; Cardiovascular Diseases/prevention & control ; Mice ; Mice, Knockout ; RAW 264.7 Cells ; Scavenger Receptors, Class E/metabolism
Czasopismo naukowe
Tytuł :
Protocatechuic Acid Inhibits Vulnerable Atherosclerotic Lesion Progression in Older Apoe-/- Mice.
Autorzy :
Zheng J; Department of Nutrition, School of Public Health, Sun Yat-sen University (Northern Campus), Guangzhou, PR China.
Li Q; Department of Nutrition, School of Public Health, Sun Yat-sen University (Northern Campus), Guangzhou, PR China.
He L; Department of Nutrition, School of Public Health, Sun Yat-sen University (Northern Campus), Guangzhou, PR China.
Weng H; Department of Nutrition, School of Public Health, Sun Yat-sen University (Northern Campus), Guangzhou, PR China.
Su D; Department of Clinical Nutrition, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, PR China.
Liu X; Department of Nutrition, School of Public Health, Sun Yat-sen University (Northern Campus), Guangzhou, PR China.
Ling W; Department of Nutrition, School of Public Health, Sun Yat-sen University (Northern Campus), Guangzhou, PR China.; Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Guangzhou, PR China.; Guangdong Engineering Technology Research Center of Nutrition Translation, Guangzhou, PR China.
Wang D; Department of Nutrition, School of Public Health, Sun Yat-sen University (Northern Campus), Guangzhou, PR China.; Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Guangzhou, PR China.; Guangdong Engineering Technology Research Center of Nutrition Translation, Guangzhou, PR China.
Pokaż więcej
Źródło :
The Journal of nutrition [J Nutr] 2020 May 01; Vol. 150 (5), pp. 1167-1177.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apolipoproteins E/*deficiency
Atherosclerosis/*pathology
Atherosclerosis/*prevention & control
Hydroxybenzoates/*administration & dosage
Animals ; Anti-Inflammatory Agents ; Apolipoproteins E/genetics ; Apolipoproteins E/physiology ; Cells, Cultured ; Dietary Supplements ; Disease Models, Animal ; Gene Expression/drug effects ; Interleukin-1beta/metabolism ; Macrophages, Peritoneal/drug effects ; Macrophages, Peritoneal/physiology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mitogen-Activated Protein Kinase 1/antagonists & inhibitors ; Mitogen-Activated Protein Kinase 1/physiology ; Mitogen-Activated Protein Kinase 3/antagonists & inhibitors ; NF-kappa B/metabolism ; c-Mer Tyrosine Kinase/genetics ; c-Mer Tyrosine Kinase/physiology
Czasopismo naukowe
Tytuł :
Effects of endothelial progenitor cells transplantation on hyperlipidemia associated kidney damage in ApoE knockout mouse model.
Autorzy :
Gong P; Department of Endocrinology, Qilu Hospital of Shandong University, Shandong University, Jinan, Shandong, 250012, China.
Zhang Z; Department of Endocrinology and Metabology, the First Affiliated Hospital of Shandong First Medical University, Jinan, 250014, China.; Department of Endocrinology and Metabology, Shandong Provincial Qianfoshan Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250014, China.
Zhang D; Department of Cardiovascular Medicine, Ninth Hospital of Xi'an, Xi'an, 710054, China.
Zou Z; Department of Endocrinology, Qilu Hospital of Shandong University, Shandong University, Jinan, Shandong, 250012, China.
Zhang Q; Department of Endocrinology, Qilu Hospital of Shandong University, Shandong University, Jinan, Shandong, 250012, China.
Ma H; Department of Endocrinology, Qilu Hospital of Shandong University, Shandong University, Jinan, Shandong, 250012, China.
Li J; Quality control office, People's Hospital of Gaoqing, Zibo, 256300, China.
Liao L; Department of Endocrinology and Metabology, the First Affiliated Hospital of Shandong First Medical University, Jinan, 250014, China. .; Department of Endocrinology and Metabology, Shandong Provincial Qianfoshan Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250014, China. .
Dong J; Department of Endocrinology, Qilu Hospital of Shandong University, Shandong University, Jinan, Shandong, 250012, China. .
Pokaż więcej
Źródło :
Lipids in health and disease [Lipids Health Dis] 2020 Mar 24; Vol. 19 (1), pp. 53. Date of Electronic Publication: 2020 Mar 24.
Typ publikacji :
Journal Article
MeSH Terms :
Apolipoproteins E/*metabolism
Bone Marrow Cells/*cytology
Endothelial Progenitor Cells/*transplantation
Hyperlipidemias/*therapy
Kidney/*metabolism
Animals ; Apolipoproteins E/deficiency ; Apolipoproteins E/genetics ; Blotting, Western ; Immunohistochemistry ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Signal Transduction ; Smad2 Protein/metabolism ; Smad3 Protein/metabolism ; Splenectomy ; Transforming Growth Factor beta/metabolism
Czasopismo naukowe
Tytuł :
APOE polymorphism in ATTR amyloidosis patients treated with lipid nanoparticle siRNA.
Autorzy :
Niemietz C; Medizinische Klinik B für Gastroenterologie und Hepatologie, Universitätsklinikum Münster, Münster, Germany.
Nadzemova O; Medizinische Klinik B für Gastroenterologie und Hepatologie, Universitätsklinikum Münster, Münster, Germany.
Zibert A; Medizinische Klinik B für Gastroenterologie und Hepatologie, Universitätsklinikum Münster, Münster, Germany.
Schmidt HH; Medizinische Klinik B für Gastroenterologie und Hepatologie, Universitätsklinikum Münster, Münster, Germany.
Pokaż więcej
Źródło :
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis [Amyloid] 2020 Mar; Vol. 27 (1), pp. 45-51. Date of Electronic Publication: 2019 Oct 25.
Typ publikacji :
Journal Article; Video-Audio Media
MeSH Terms :
Amyloid Neuropathies, Familial*/blood
Amyloid Neuropathies, Familial*/drug therapy
Amyloid Neuropathies, Familial*/genetics
Apolipoproteins E*/blood
Apolipoproteins E*/genetics
Polymorphism, Genetic*
Nanoparticles/*therapeutic use
RNA, Small Interfering/*administration & dosage
Female ; Gene Knockdown Techniques ; Gene Silencing/drug effects ; Genotype ; Hep G2 Cells ; Humans ; Male ; Prealbumin/genetics ; Prealbumin/metabolism
SCR Disease Name :
Amyloidosis, Hereditary, Transthyretin-Related
Czasopismo naukowe
Tytuł :
VX-765 attenuates atherosclerosis in ApoE deficient mice by modulating VSMCs pyroptosis.
Autorzy :
Li Y; Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Niu X; Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Xu H; Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Li Q; Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Meng L; Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
He M; Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Zhang J; Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Zhang Z; Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Zhang Z; Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, 430060, China. Electronic address: .
Pokaż więcej
Źródło :
Experimental cell research [Exp Cell Res] 2020 Apr 01; Vol. 389 (1), pp. 111847. Date of Electronic Publication: 2020 Jan 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apolipoproteins E/*genetics
Atherosclerosis/*prevention & control
Dipeptides/*therapeutic use
Muscle, Smooth, Vascular/*drug effects
Pyroptosis/*drug effects
para-Aminobenzoates/*therapeutic use
Animals ; Apolipoproteins E/deficiency ; Atherosclerosis/genetics ; Atherosclerosis/pathology ; Disease Models, Animal ; Disease Progression ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Muscle, Smooth, Vascular/pathology ; Muscle, Smooth, Vascular/physiology ; Myocytes, Smooth Muscle/drug effects ; Myocytes, Smooth Muscle/pathology ; Myocytes, Smooth Muscle/physiology
Czasopismo naukowe
Tytuł :
Myriocin and d-PDMP ameliorate atherosclerosis in ApoE-/- mice via reducing lipid uptake and vascular inflammation.
Autorzy :
Yu Z; Department of Neurology, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing 100034, China.
Peng Q; Department of Neurology, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing 100034, China.
Li S; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Institute of Analytical Chemistry, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
Hao H; Department of Neurology, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing 100034, China.
Deng J; Department of Neurology, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing 100034, China.
Meng L; Department of Neurology, Beijing Hospital, National Center of Gerontology, No.1 Dahua Road, Dong Dan, Beijing 100730, China.
Shen Z; Department of Neurology, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing 100034, China.
Yu W; Department of Neurology, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing 100034, China.
Nan D; Department of Neurology, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing 100034, China.
Bai Y; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Institute of Analytical Chemistry, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
Huang Y; Department of Neurology, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing 100034, China.
Pokaż więcej
Źródło :
Clinical science (London, England : 1979) [Clin Sci (Lond)] 2020 Mar 13; Vol. 134 (5), pp. 439-458.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apolipoproteins E/*deficiency
Atherosclerosis/*prevention & control
Fatty Acids, Monounsaturated/*pharmacology
Lipid Metabolism/*drug effects
Morpholines/*pharmacology
Vasculitis/*prevention & control
Animals ; Anticholesteremic Agents/pharmacology ; Apolipoproteins E/genetics ; Atherosclerosis/metabolism ; Atorvastatin/pharmacology ; Biological Transport/drug effects ; Ceramides/antagonists & inhibitors ; Ceramides/metabolism ; Glycosphingolipids/antagonists & inhibitors ; Glycosphingolipids/metabolism ; Immunosuppressive Agents/pharmacology ; Lipids/blood ; Lipids/pharmacokinetics ; Mice, Inbred C57BL ; Mice, Knockout ; Plaque, Atherosclerotic/metabolism ; Plaque, Atherosclerotic/pathology ; Plaque, Atherosclerotic/prevention & control ; Vasculitis/metabolism
Czasopismo naukowe
Tytuł :
Long-term exposure to ambient air pollution, APOE-ε4 status, and cognitive decline in a cohort of older adults in northern Manhattan.
Autorzy :
Kulick ER; Department of Epidemiology, Brown University School of Public Health, Providence, RI, USA; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA. Electronic address: .
Elkind MSV; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA; Gertrude H Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Boehme AK; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA; Gertrude H Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Joyce NR; Department of Epidemiology, Brown University School of Public Health, Providence, RI, USA.
Schupf N; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA; Taub Institute for Research on Alzheimer Disease and the Aging Brain, Columbia University, New York, NY, USA; Gertrude H Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Kaufman JD; Departments of Environmental and Occupational Health Sciences, and Epidemiology, University of Washington School of Public Health, Seattle, WA, USA.
Mayeux R; Department of Epidemiology, Brown University School of Public Health, Providence, RI, USA; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA; Taub Institute for Research on Alzheimer Disease and the Aging Brain, Columbia University, New York, NY, USA; Gertrude H Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; Department of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Manly JJ; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA; Taub Institute for Research on Alzheimer Disease and the Aging Brain, Columbia University, New York, NY, USA; Gertrude H Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Wellenius GA; Department of Epidemiology, Brown University School of Public Health, Providence, RI, USA.
Pokaż więcej
Źródło :
Environment international [Environ Int] 2020 Mar; Vol. 136, pp. 105440. Date of Electronic Publication: 2020 Jan 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Air Pollutants*/toxicity
Air Pollution*
Apolipoproteins E*/drug effects
Cognitive Dysfunction*/chemically induced
Aged ; Apolipoprotein E4 ; Female ; Genotype ; Humans ; Male ; Prospective Studies ; Washington
Czasopismo naukowe
Tytuł :
APOE region molecular signatures of Alzheimer's disease across races/ethnicities.
Autorzy :
Kulminski AM; Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC, USA. Electronic address: .
Shu L; Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC, USA.
Loika Y; Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC, USA.
Nazarian A; Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC, USA.
Arbeev K; Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC, USA.
Ukraintseva S; Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC, USA.
Yashin A; Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC, USA.
Culminskaya I; Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC, USA.
Pokaż więcej
Źródło :
Neurobiology of aging [Neurobiol Aging] 2020 Mar; Vol. 87, pp. 141.e1-141.e8. Date of Electronic Publication: 2019 Nov 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural
MeSH Terms :
Polymorphism, Single Nucleotide*
Alzheimer Disease/*ethnology
Alzheimer Disease/*genetics
Apolipoproteins E/*genetics
Continental Population Groups/*genetics
Alleles ; Apolipoproteins E/adverse effects ; Haplotypes ; Heterozygote ; Homozygote ; Humans ; Linkage Disequilibrium/genetics ; Risk Factors
Czasopismo naukowe
Tytuł :
Shikonin attenuates hyperhomocysteinemia-induced CD4 mice by metabolic suppression.
Autorzy :
Lü SL; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, 100191, China.; State Key Laboratory of Bioactive Substances and Function of Natural Medicine, Institute of Materia Medica, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100050, China.
Dang GH; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, 100191, China.
Deng JC; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, 100191, China.
Liu HY; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, 100191, China.
Liu B; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, 100191, China.
Yang J; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, 100191, China.
Ma XL; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, 100191, China.
Miao YT; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, 100191, China.
Jiang CT; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, 100191, China.
Xu QB; Cardiovascular Division, BHF Centre for Vascular Regeneration, King's College London, London, SE5 9NU, UK.
Wang X; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, 100191, China. .
Feng J; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, 100191, China. .; Department of Integration of Chinese and Western Medicine, School of Basic Medical Sciences, Peking University, Beijing, 100191, China. .
Pokaż więcej
Źródło :
Acta pharmacologica Sinica [Acta Pharmacol Sin] 2020 Jan; Vol. 41 (1), pp. 47-55. Date of Electronic Publication: 2019 Oct 13.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Inflammatory Agents, Non-Steroidal/*pharmacology
Apolipoproteins E/*deficiency
Atherosclerosis/*drug therapy
Hyperhomocysteinemia/*drug therapy
Inflammation/*drug therapy
Naphthoquinones/*pharmacology
Animals ; Anti-Inflammatory Agents, Non-Steroidal/administration & dosage ; Apolipoproteins E/genetics ; Apolipoproteins E/metabolism ; Atherosclerosis/metabolism ; CD4-Positive T-Lymphocytes/drug effects ; CD4-Positive T-Lymphocytes/metabolism ; Dose-Response Relationship, Drug ; Female ; Hyperhomocysteinemia/metabolism ; Inflammation/metabolism ; Injections, Intraperitoneal ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Naphthoquinones/administration & dosage
Czasopismo naukowe
Tytuł :
A serum protein signature of APOE genotypes in centenarians.
Autorzy :
Sebastiani P; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts.
Monti S; Bioinformatics Program, Boston University, Boston, Massachusetts.; Division of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts.
Morris M; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.
Gurinovich A; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts.; Bioinformatics Program, Boston University, Boston, Massachusetts.
Toshiko T; Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland.
Andersen SL; Geriatrics Section, Department of Medicine, School of Medicine and Boston Medical Center, Boston University, Boston, MA.
Sweigart B; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts.
Ferrucci L; Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland.
Jennings LL; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.
Glass DJ; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.
Perls TT; Geriatrics Section, Department of Medicine, School of Medicine and Boston Medical Center, Boston University, Boston, MA.
Pokaż więcej
Źródło :
Aging cell [Aging Cell] 2019 Dec; Vol. 18 (6), pp. e13023. Date of Electronic Publication: 2019 Aug 05.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Alzheimer Disease/*genetics
Apolipoproteins E/*genetics
Adult ; Aged ; Aged, 80 and over ; Alzheimer Disease/blood ; Alzheimer Disease/metabolism ; Apolipoproteins E/blood ; Apolipoproteins E/metabolism ; Cohort Studies ; Female ; Fluorescence ; Genotype ; Humans ; Male ; Middle Aged ; Prospective Studies ; Proteomics ; Young Adult
Czasopismo naukowe
Tytuł :
An integration-free iPSC line, ICCSICi007-A, derived from a female Alzheimer's disease patient with the APOE-ε4/ε4 alleles.
Autorzy :
Díaz-Guerra E; Instituto Cajal, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
Rodríguez-Traver E; Instituto Cajal, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
Moreno-Jiménez EP; Instituto Cajal, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
de Rojas I; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain; Fundació ACE-Barcelona Alzheimer Treatment and Research Center, Barcelona, Spain.
Rodríguez C; Servicio de Bioquímica Clínica, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Orera M; Servicio de Bioquímica Clínica, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Hernández I; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain; Fundació ACE-Barcelona Alzheimer Treatment and Research Center, Barcelona, Spain.
Ruiz A; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain; Fundació ACE-Barcelona Alzheimer Treatment and Research Center, Barcelona, Spain.
Vicario C; Instituto Cajal, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain. Electronic address: .
Pokaż więcej
Źródło :
Stem cell research [Stem Cell Res] 2019 Dec; Vol. 41, pp. 101588. Date of Electronic Publication: 2019 Oct 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alleles*
Alzheimer Disease*/genetics
Alzheimer Disease*/metabolism
Alzheimer Disease*/pathology
Apolipoproteins E*/genetics
Apolipoproteins E*/metabolism
Dermis*/metabolism
Dermis*/pathology
Fibroblasts*/metabolism
Fibroblasts*/pathology
Induced Pluripotent Stem Cells*
Cell Line ; Cellular Reprogramming Techniques ; Female ; Humans
Czasopismo naukowe
Tytuł :
N ε -Carboxymethyl-Lysine Negatively Regulates Foam Cell Migration via the Vav1/Rac1 Pathway.
Autorzy :
Bao Z; Department of Cardiology, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China.; Department of Internal Medicine, Affiliated Wuxi Maternity and Child Health Care Hospital of Nanjing Medical University, Wuxi 214000, China.
Zhang L; Department of Cardiology, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China.
Li L; Department of Pathology, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China.
Yan J; Department of Cardiology, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China.
Pang Q; Department of Cardiology, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China.
Sun Z; Department of Cardiology, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China.
Geng Y; Department of Cardiology, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China.
Jing L; Department of Cardiology, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China.
Shao C; Department of Cardiology, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China.
Wang Z; Department of Cardiology, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China.
Pokaż więcej
Źródło :
Journal of immunology research [J Immunol Res] 2020 Feb 28; Vol. 2020, pp. 1906204. Date of Electronic Publication: 2020 Feb 28 (Print Publication: 2020).
Typ publikacji :
Journal Article
MeSH Terms :
Apolipoproteins E/*metabolism
Atherosclerosis/*metabolism
Diabetic Foot/*metabolism
Foam Cells/*physiology
Lysine/*analogs & derivatives
Proto-Oncogene Proteins c-vav/*metabolism
rac1 GTP-Binding Protein/*metabolism
Amputation ; Animals ; Apolipoproteins E/genetics ; Atherosclerosis/pathology ; Cell Movement ; Cells, Cultured ; Diabetic Foot/pathology ; Humans ; Lysine/metabolism ; Mice ; Mice, Knockout ; Signal Transduction
Czasopismo naukowe
Tytuł :
Effects of inhaled air pollution on markers of integrity, inflammation, and microbiota profiles of the intestines in Apolipoprotein E knockout mice.
Autorzy :
Fitch MN; Department of Biological Sciences, Advanced Environmental Research Institute, University of North Texas, Denton, TX 76201, USA.
Phillippi D; Department of Biological Sciences, Advanced Environmental Research Institute, University of North Texas, Denton, TX 76201, USA.
Zhang Y; Center for Medical Genetics, Institute of Molecular Medicine, University of North Texas Health Sciences Center, Fort Worth, TX 76107, USA.
Lucero J; Department of Biological Sciences, Advanced Environmental Research Institute, University of North Texas, Denton, TX 76201, USA.
Pandey RS; Department of Biological Sciences, University of North Texas, Denton, TX 76201, USA.
Liu J; Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM 87108, USA.
Brower J; Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM 87108, USA.
Allen MS; Center for Medical Genetics, Institute of Molecular Medicine, University of North Texas Health Sciences Center, Fort Worth, TX 76107, USA.
Campen MJ; College of Pharmacy, University of New Mexico, Albuquerque, NM, USA.
McDonald JD; Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM 87108, USA.
Lund AK; Department of Biological Sciences, Advanced Environmental Research Institute, University of North Texas, Denton, TX 76201, USA. Electronic address: .
Pokaż więcej
Źródło :
Environmental research [Environ Res] 2020 Feb; Vol. 181, pp. 108913. Date of Electronic Publication: 2019 Nov 14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Apolipoproteins E*
Gastrointestinal Microbiome*
Air Pollutants/*toxicity
Air Pollution ; Animals ; Inflammation ; Intestines ; Male ; Mice ; Mice, Knockout ; RNA, Ribosomal, 16S ; Vehicle Emissions
Czasopismo naukowe
Tytuł :
Redefining transcriptional regulation of the APOE gene and its association with Alzheimer's disease.
Autorzy :
Lee EG; Geriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, WA, United States of America.
Tulloch J; Geriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, WA, United States of America.
Chen S; Geriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, WA, United States of America.
Leong L; Geriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, WA, United States of America.
Saxton AD; Geriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, WA, United States of America.
Kraemer B; Geriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, WA, United States of America.; Department of Medicine, University of Washington, Seattle, WA, United States of America.
Darvas M; Department of Pathology, University of Washington, Seattle, WA, United States of America.
Keene CD; Department of Pathology, University of Washington, Seattle, WA, United States of America.
Shutes-David A; Geriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, WA, United States of America.
Todd K; Geriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, WA, United States of America.
Millard S; Geriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, WA, United States of America.
Yu CE; Geriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, WA, United States of America.; Department of Medicine, University of Washington, Seattle, WA, United States of America.
Pokaż więcej
Źródło :
PloS one [PLoS One] 2020 Jan 24; Vol. 15 (1), pp. e0227667. Date of Electronic Publication: 2020 Jan 24 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Alzheimer Disease/*genetics
Apolipoproteins E/*genetics
Brain/*metabolism
Aged ; Aged, 80 and over ; Alzheimer Disease/metabolism ; Apolipoproteins E/metabolism ; Autopsy ; Case-Control Studies ; Cerebellum/metabolism ; CpG Islands ; DNA Methylation ; Female ; Frontal Lobe/metabolism ; Gene Expression Regulation ; Genetic Predisposition to Disease ; Humans ; Male ; Polymorphism, Single Nucleotide ; RNA, Circular/genetics ; RNA, Circular/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism
Czasopismo naukowe
Tytuł :
PM2.5 exposure induces vascular dysfunction via NO generated by iNOS in lung of ApoE-/- mouse.
Autorzy :
Long MH; Institute of Military Cognitive and Brain Sciences, Beijing, 100850, China.
Zhu XM; Institute of Military Cognitive and Brain Sciences, Beijing, 100850, China.
Wang Q; National Institute of Environmental Health Chinese Center for Disease Control and Prevention, Beijing, 100021, China.
Chen Y; Institute of Military Cognitive and Brain Sciences, Beijing, 100850, China.
Gan XD; Institute of Military Cognitive and Brain Sciences, Beijing, 100850, China.
Li F; Institute of Military Cognitive and Brain Sciences, Beijing, 100850, China.
Fu WL; Institute of Military Cognitive and Brain Sciences, Beijing, 100850, China.
Xing WW; Institute of Military Cognitive and Brain Sciences, Beijing, 100850, China.
Xu DQ; National Institute of Environmental Health Chinese Center for Disease Control and Prevention, Beijing, 100021, China.
Xu DG; Institute of Military Cognitive and Brain Sciences, Beijing, 100850, China.
Pokaż więcej
Źródło :
International journal of biological sciences [Int J Biol Sci] 2020 Jan 01; Vol. 16 (1), pp. 49-60. Date of Electronic Publication: 2020 Jan 01 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apolipoproteins E/*metabolism
Inflammation/*metabolism
Nitric Oxide Synthase Type II/*metabolism
Particulate Matter/*toxicity
Animals ; Apolipoproteins E/genetics ; Blotting, Western ; Immunohistochemistry ; Inflammation/genetics ; Interleukin-6/blood ; Male ; Mice ; Mice, Mutant Strains ; Nitric Oxide Synthase Type II/genetics ; Oxidative Stress/drug effects ; Tumor Necrosis Factor-alpha/blood
Czasopismo naukowe
Tytuł :
ApoE (Apolipoprotein E) in Brain Pericytes Regulates Endothelial Function in an Isoform-Dependent Manner by Modulating Basement Membrane Components.
Autorzy :
Yamazaki Y; From the Department of Neuroscience (Y.Y., M.S., A.Y., T.K.), Mayo Clinic, Jacksonville, FL.
Shinohara M; From the Department of Neuroscience (Y.Y., M.S., A.Y., T.K.), Mayo Clinic, Jacksonville, FL.
Yamazaki A; From the Department of Neuroscience (Y.Y., M.S., A.Y., T.K.), Mayo Clinic, Jacksonville, FL.
Ren Y; Department of Health Sciences Research (Y.R., Y.W.A.), Mayo Clinic, Jacksonville, FL.
Asmann YW; Department of Health Sciences Research (Y.R., Y.W.A.), Mayo Clinic, Jacksonville, FL.
Kanekiyo T; From the Department of Neuroscience (Y.Y., M.S., A.Y., T.K.), Mayo Clinic, Jacksonville, FL.
Bu G; From the Department of Neuroscience (Y.Y., M.S., A.Y., T.K.), Mayo Clinic, Jacksonville, FL.
Pokaż więcej
Źródło :
Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2020 Jan; Vol. 40 (1), pp. 128-144. Date of Electronic Publication: 2019 Oct 31.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation*
Alzheimer Disease/*genetics
Apolipoproteins E/*genetics
Basement Membrane/*metabolism
Brain/*metabolism
Endothelium, Vascular/*metabolism
Pericytes/*metabolism
Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Animals ; Apolipoproteins E/biosynthesis ; Basement Membrane/pathology ; Brain/pathology ; Cells, Cultured ; Disease Models, Animal ; Endothelium, Vascular/pathology ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Pericytes/pathology ; Protein Isoforms
Czasopismo naukowe
Tytuł :
APOE genetic background and sex confer different vulnerabilities to postnatal chlorpyrifos exposure and modulate the response to cholinergic drugs.
Autorzy :
Guardia-Escote L; Research in Neurobehavior and Health (NEUROLAB), Universitat Rovira i Virgili, Tarragona, Spain; Department of Biochemistry and Biotechnology, Universitat Rovira i Virgili, Tarragona, Spain; Laboratory of Toxicology and Environmental Health, School of Medicine, IISPV, Universitat Rovira i Virgili, Reus, Spain.
Basaure P; Research in Neurobehavior and Health (NEUROLAB), Universitat Rovira i Virgili, Tarragona, Spain; Laboratory of Toxicology and Environmental Health, School of Medicine, IISPV, Universitat Rovira i Virgili, Reus, Spain; Department of Psychology and Research Center for Behavior Assessment (CRAMC), Universitat Rovira i Virgili, Tarragona, Spain.
Peris-Sampedro F; Research in Neurobehavior and Health (NEUROLAB), Universitat Rovira i Virgili, Tarragona, Spain; Department of Physiology/Endocrinology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
Biosca-Brull J; Research in Neurobehavior and Health (NEUROLAB), Universitat Rovira i Virgili, Tarragona, Spain; Laboratory of Toxicology and Environmental Health, School of Medicine, IISPV, Universitat Rovira i Virgili, Reus, Spain; Department of Psychology and Research Center for Behavior Assessment (CRAMC), Universitat Rovira i Virgili, Tarragona, Spain.
Cabré M; Research in Neurobehavior and Health (NEUROLAB), Universitat Rovira i Virgili, Tarragona, Spain; Department of Biochemistry and Biotechnology, Universitat Rovira i Virgili, Tarragona, Spain.
Sánchez-Santed F; Department of Psychology and CIAIMBITAL, Almeria University-ceiA3, Almeria, Spain.
Domingo JL; Laboratory of Toxicology and Environmental Health, School of Medicine, IISPV, Universitat Rovira i Virgili, Reus, Spain.
Colomina MT; Research in Neurobehavior and Health (NEUROLAB), Universitat Rovira i Virgili, Tarragona, Spain; Laboratory of Toxicology and Environmental Health, School of Medicine, IISPV, Universitat Rovira i Virgili, Reus, Spain; Department of Psychology and Research Center for Behavior Assessment (CRAMC), Universitat Rovira i Virgili, Tarragona, Spain. Electronic address: .
Pokaż więcej
Źródło :
Behavioural brain research [Behav Brain Res] 2019 Dec 30; Vol. 376, pp. 112195. Date of Electronic Publication: 2019 Aug 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apolipoproteins E/*genetics
Chlorpyrifos/*adverse effects
Memory/*drug effects
Animals ; Apolipoprotein E3/genetics ; Apolipoprotein E4/genetics ; Apolipoproteins E/metabolism ; Chlorpyrifos/metabolism ; Chlorpyrifos/pharmacology ; Cholinergic Agents/pharmacology ; Cholinergic Neurons/drug effects ; Disease Susceptibility/metabolism ; Exploratory Behavior/drug effects ; Female ; GABAergic Neurons/drug effects ; Genetic Predisposition to Disease/genetics ; Genotype ; Male ; Maze Learning/drug effects ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Reaction Time/drug effects ; Recognition, Psychology/drug effects ; Scopolamine ; Sex Characteristics ; Sex Factors
Czasopismo naukowe

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies