Temat: "Apolipoproteins E" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Loss of Lipid Carrier ApoE Exacerbates Brain Glial and Inflammatory Responses after Lysosomal GBA1 Inhibition.
Autorzy:: Connolly KJ; Departments of Psychiatry and Neurology Harvard Medical School, Neuroregeneration Institute, McLean Hospital, Belmont, MA 02478, USA.
Margaria J; Departments of Psychiatry and Neurology Harvard Medical School, Neuroregeneration Institute, McLean Hospital, Belmont, MA 02478, USA.
Di Biase E; Departments of Psychiatry and Neurology Harvard Medical School, Neuroregeneration Institute, McLean Hospital, Belmont, MA 02478, USA.
Cooper O; Departments of Psychiatry and Neurology Harvard Medical School, Neuroregeneration Institute, McLean Hospital, Belmont, MA 02478, USA.
Hallett PJ; Departments of Psychiatry and Neurology Harvard Medical School, Neuroregeneration Institute, McLean Hospital, Belmont, MA 02478, USA.
Isacson O; Departments of Psychiatry and Neurology Harvard Medical School, Neuroregeneration Institute, McLean Hospital, Belmont, MA 02478, USA.; Pokaż więcej
Źródło:: Cells [Cells] 2023 Nov 02; Vol. 12 (21). Date of Electronic Publication: 2023 Nov 02.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Glucosylceramidase*/genetics
Glucosylceramidase*/metabolism
Brain*/metabolism
Humans ; Mice ; Animals ; Lysosomes/metabolism ; Apolipoproteins E ; Glycolipids/metabolism

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Skocz do pozycji: 2.

Tytuł:: APOE alleles are associated with sex-specific structural differences in brain regions affected in Alzheimer's disease and related dementia.
Autorzy:: Savignac C; Department of Biomedical Engineering, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.
Villeneuve S; Department of Neurology and Neurosurgery, Montreal Neurological Institute (MNI), Faculty of Medicine, McGill University, Montreal, Quebec, Canada.; McConnell Brain Imaging Centre (BIC), MNI, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.; Department of Psychiatry, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.; Centre for Studies in the Prevention of Alzheimer's Disease, Douglas Mental Health Institute, McGill University, Montreal, Quebec, Canada.
Badhwar A; Department of Pharmacology and Physiology, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada.; Centre de recherche de l'Institut universitaire de gériatrie de Montréal (CRIUGM), Montreal, Quebec, Canada.
Saltoun K; Department of Biomedical Engineering, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.
Shafighi K; Department of Biomedical Engineering, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.
Zajner C; Department of Biomedical Engineering, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.
Sharma V; Department of Biomedical Engineering, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.
Gagliano Taliun SA; Department of Neurosciences & Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada.; Montreal Heart Institute, Montréal, Quebec, Canada.
Farhan S; Department of Neurology and Neurosurgery, Montreal Neurological Institute (MNI), Faculty of Medicine, McGill University, Montreal, Quebec, Canada.; Department of Human Genetics, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.
Poirier J; Department of Neurology and Neurosurgery, Montreal Neurological Institute (MNI), Faculty of Medicine, McGill University, Montreal, Quebec, Canada.; Department of Psychiatry, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.; Centre for Studies in the Prevention of Alzheimer's Disease, Douglas Mental Health Institute, McGill University, Montreal, Quebec, Canada.
Bzdok D; Department of Biomedical Engineering, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.; McConnell Brain Imaging Centre (BIC), MNI, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.; School of Computer Science, McGill University, Montreal, Quebec, Canada.; Mila-Quebec Artificial Intelligence Institute, Montreal, Quebec, Canada.; Pokaż więcej
Źródło:: PLoS biology [PLoS Biol] 2022 Dec 13; Vol. 20 (12), pp. e3001863. Date of Electronic Publication: 2022 Dec 13 (Print Publication: 2022).
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Alzheimer Disease*/genetics
Apolipoproteins E*/genetics
Brain*/anatomy & histology
Sex Characteristics*
Female ; Humans ; Male ; Alleles ; Genotype

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Skocz do pozycji: 3.

Tytuł:: Novel brain-targeted nanomicelles for anti-glioma therapy mediated by the ApoE-enriched protein corona in vivo.
Autorzy:: Zhang ZA; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, People's Republic of China.; Beijing Key Laboratory of Drug Delivery Technology and Novel Formulations, Department of Pharmaceutics, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
Xin X; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, People's Republic of China.; Beijing Key Laboratory of Drug Delivery Technology and Novel Formulations, Department of Pharmaceutics, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
Liu C; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, People's Republic of China.; Beijing Key Laboratory of Drug Delivery Technology and Novel Formulations, Department of Pharmaceutics, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
Liu YH; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, People's Republic of China.; Beijing Key Laboratory of Drug Delivery Technology and Novel Formulations, Department of Pharmaceutics, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
Duan HX; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, People's Republic of China.; Beijing Key Laboratory of Drug Delivery Technology and Novel Formulations, Department of Pharmaceutics, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
Qi LL; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, People's Republic of China.; Beijing Key Laboratory of Drug Delivery Technology and Novel Formulations, Department of Pharmaceutics, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
Zhang YY; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, People's Republic of China.; Beijing Key Laboratory of Drug Delivery Technology and Novel Formulations, Department of Pharmaceutics, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
Zhao HM; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, People's Republic of China.; Beijing Key Laboratory of Drug Delivery Technology and Novel Formulations, Department of Pharmaceutics, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
Chen LQ; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, People's Republic of China.; Beijing Key Laboratory of Drug Delivery Technology and Novel Formulations, Department of Pharmaceutics, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
Jin MJ; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, People's Republic of China.; Beijing Key Laboratory of Drug Delivery Technology and Novel Formulations, Department of Pharmaceutics, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
Gao ZG; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, People's Republic of China. .; Beijing Key Laboratory of Drug Delivery Technology and Novel Formulations, Department of Pharmaceutics, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China. .
Huang W; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, People's Republic of China. .; Beijing Key Laboratory of Drug Delivery Technology and Novel Formulations, Department of Pharmaceutics, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China. .; Pokaż więcej
Źródło:: Journal of nanobiotechnology [J Nanobiotechnology] 2021 Dec 28; Vol. 19 (1), pp. 453. Date of Electronic Publication: 2021 Dec 28.
Typ publikacji:: Journal Article
MeSH Terms:: Protein Corona*/chemistry
Antineoplastic Agents/*administration & dosage
Apolipoproteins E/*administration & dosage
Brain/*drug effects
Glioma/*drug therapy
Nanoparticles/*administration & dosage
Amyloid beta-Peptides/administration & dosage ; Amyloid beta-Peptides/chemistry ; Amyloid beta-Peptides/pharmacokinetics ; Animals ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacokinetics ; Apolipoproteins E/chemistry ; Apolipoproteins E/pharmacokinetics ; Blood-Brain Barrier/metabolism ; Brain/metabolism ; Cell Line ; Cell Survival/drug effects ; Drug Delivery Systems ; Glioma/metabolism ; Humans ; Mice ; Micelles ; Nanoparticles/chemistry ; Paclitaxel/administration & dosage ; Paclitaxel/chemistry ; Paclitaxel/pharmacokinetics ; Peptide Fragments/administration & dosage ; Peptide Fragments/chemistry ; Peptide Fragments/pharmacokinetics ; Polyesters/administration & dosage ; Polyesters/chemistry ; Polyesters/pharmacokinetics ; Polyethylene Glycols/administration & dosage ; Polyethylene Glycols/chemistry ; Polyethylene Glycols/pharmacokinetics

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Skocz do pozycji: 4.

Tytuł:: Apolipoprotein E levels in the amygdala and prefrontal cortex predict relative regional brain volumes in irradiated Rhesus macaques.
Autorzy:: Kundu P; Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR, USA.
Zimmerman B; Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR, USA.; Advanced Imaging Research Center, Oregon Health and Science University, Portland, OR, USA.; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Perez R; Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR, USA.
Whitlow CT; Department of Radiology, Radiology Informatics & Image Processing Laboratory (RIIPL), Wake Forest University, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Cline JM; Department of Radiology, Radiology Informatics & Image Processing Laboratory (RIIPL), Wake Forest University, Wake Forest University School of Medicine, Winston-Salem, NC, USA.; Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Olson JD; Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Andrews RN; Department of Radiology, Radiology Informatics & Image Processing Laboratory (RIIPL), Wake Forest University, Wake Forest University School of Medicine, Winston-Salem, NC, USA.; Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Raber J; Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR, USA. .; Division of Neuroscience, Departments of Neurology and Radiation Medicine, ONPRC, Oregon Health and Science University, Portland, OR, USA. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2021 Nov 11; Vol. 11 (1), pp. 22130. Date of Electronic Publication: 2021 Nov 11.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:: Amygdala/*metabolism
Apolipoproteins E/*metabolism
Brain/*metabolism
Prefrontal Cortex/*metabolism
Animals ; Female ; Klotho Proteins/metabolism ; Macaca mulatta ; Male ; Neurons/metabolism

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Skocz do pozycji: 5.

Tytuł:: Investigating APOE, APP-Aβ metabolism genes and Alzheimer's disease GWAS hits in brain small vessel ischemic disease.
Autorzy:: Blumenau S; Department of Experimental Neurology, Center for Stroke Research Berlin (CSB), Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Foddis M; Department of Experimental Neurology, Center for Stroke Research Berlin (CSB), Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Müller S; Department of Experimental Neurology, Center for Stroke Research Berlin (CSB), Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Holtgrewe M; Berlin Institute of Health, BIH, Core Unit Bioinformatics, Berlin, Germany.
Bentele K; Berlin Institute of Health, BIH, Core Unit Bioinformatics, Berlin, Germany.
Berchtold D; Department of Experimental Neurology, Center for Stroke Research Berlin (CSB), Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Beule D; Berlin Institute of Health, BIH, Core Unit Bioinformatics, Berlin, Germany.
Dirnagl U; Department of Experimental Neurology, Center for Stroke Research Berlin (CSB), Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Sassi C; Department of Experimental Neurology, Center for Stroke Research Berlin (CSB), Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2020 Apr 28; Vol. 10 (1), pp. 7103. Date of Electronic Publication: 2020 Apr 28.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Alleles*
Alzheimer Disease*/genetics
Alzheimer Disease*/metabolism
Alzheimer Disease*/pathology
Alzheimer Disease*/physiopathology
Amyloid beta-Protein Precursor*/genetics
Amyloid beta-Protein Precursor*/metabolism
Apolipoproteins E*/genetics
Brain*/blood supply
Brain*/metabolism
Brain*/pathology
Brain Ischemia*/genetics
Brain Ischemia*/metabolism
Brain Ischemia*/pathology
Brain Ischemia*/physiopathology
Genetic Loci*
Aged ; Animals ; Disease Models, Animal ; Female ; Genome-Wide Association Study ; Humans ; Male ; Mice ; Mice, Transgenic ; Middle Aged

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Skocz do pozycji: 6.

Tytuł:: Redefining transcriptional regulation of the APOE gene and its association with Alzheimer's disease.
Autorzy:: Lee EG; Geriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, WA, United States of America.
Tulloch J; Geriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, WA, United States of America.
Chen S; Geriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, WA, United States of America.
Leong L; Geriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, WA, United States of America.
Saxton AD; Geriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, WA, United States of America.
Kraemer B; Geriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, WA, United States of America.; Department of Medicine, University of Washington, Seattle, WA, United States of America.
Darvas M; Department of Pathology, University of Washington, Seattle, WA, United States of America.
Keene CD; Department of Pathology, University of Washington, Seattle, WA, United States of America.
Shutes-David A; Geriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, WA, United States of America.
Todd K; Geriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, WA, United States of America.
Millard S; Geriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, WA, United States of America.
Yu CE; Geriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, WA, United States of America.; Department of Medicine, University of Washington, Seattle, WA, United States of America.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2020 Jan 24; Vol. 15 (1), pp. e0227667. Date of Electronic Publication: 2020 Jan 24 (Print Publication: 2020).
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:: Alzheimer Disease/*genetics
Apolipoproteins E/*genetics
Brain/*metabolism
Aged ; Aged, 80 and over ; Alzheimer Disease/metabolism ; Apolipoproteins E/metabolism ; Autopsy ; Case-Control Studies ; Cerebellum/metabolism ; CpG Islands ; DNA Methylation ; Female ; Frontal Lobe/metabolism ; Gene Expression Regulation ; Genetic Predisposition to Disease ; Humans ; Male ; Polymorphism, Single Nucleotide ; RNA, Circular/genetics ; RNA, Circular/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism

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Skocz do pozycji: 7.

Tytuł:: Investigation of base excision repair gene variants in late-onset Alzheimer's disease.
Autorzy:: Ertuzun T; Department of Molecular Biology and Genetics.; Department of Medical Biotechnology, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey.
Semerci A; Department of Medical Biotechnology, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey.
Cakir ME; Department of Neurology, Medeniyet University, Goztepe Training and Research Hospital, Istanbul, Turkey.
Ekmekcioglu A; Department of Medical Biotechnology, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey.
Gok MO; Department of Medical Biotechnology, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey.
Soltys DT; Departmento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, Brazil.
de Souza-Pinto NC; Departmento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, Brazil.
Sezerman U; Department of Biostatistics and Medical Informatics, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey.
Muftuoglu M; Department of Molecular Biology and Genetics.; Department of Medical Biotechnology, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2019 Aug 15; Vol. 14 (8), pp. e0221362. Date of Electronic Publication: 2019 Aug 15 (Print Publication: 2019).
Typ publikacji:: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Brain*
DNA Repair*
Polymorphism, Genetic*
Alzheimer Disease/*genetics
Apolipoproteins E/*metabolism
DNA Glycosylases/*genetics
DNA Polymerase beta/*genetics
Uracil-DNA Glycosidase/*genetics
Aged ; Aged, 80 and over ; Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Apolipoproteins E/genetics ; DNA Glycosylases/metabolism ; DNA Polymerase beta/metabolism ; Female ; Humans ; Male ; Risk Factors ; Uracil-DNA Glycosidase/metabolism

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Skocz do pozycji: 8.

Tytuł:: APOE genotype dependent molecular abnormalities in the cerebrovasculature of Alzheimer's disease and age-matched non-demented brains.
Autorzy:: Ojo JO; Department of Experimental Neuropathology, Roskamp Institute, Sarasota, FL, 34243, USA. .; James A. Haley Veterans' Hospital, Tampa, FL, USA. .; The Open University, Milton Keynes, UK. .
Reed JM; Department of Experimental Neuropathology, Roskamp Institute, Sarasota, FL, 34243, USA.; Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT, USA.
Crynen G; Department of Experimental Neuropathology, Roskamp Institute, Sarasota, FL, 34243, USA.
Vallabhaneni P; Department of Experimental Neuropathology, Roskamp Institute, Sarasota, FL, 34243, USA.
Evans J; Department of Experimental Neuropathology, Roskamp Institute, Sarasota, FL, 34243, USA.
Shackleton B; Department of Experimental Neuropathology, Roskamp Institute, Sarasota, FL, 34243, USA.; The Open University, Milton Keynes, UK.
Eisenbaum M; Department of Experimental Neuropathology, Roskamp Institute, Sarasota, FL, 34243, USA.; The Open University, Milton Keynes, UK.
Ringland C; Department of Experimental Neuropathology, Roskamp Institute, Sarasota, FL, 34243, USA.; The Open University, Milton Keynes, UK.
Edsell A; Department of Experimental Neuropathology, Roskamp Institute, Sarasota, FL, 34243, USA.
Mullan M; Department of Experimental Neuropathology, Roskamp Institute, Sarasota, FL, 34243, USA.; The Open University, Milton Keynes, UK.
Crawford F; Department of Experimental Neuropathology, Roskamp Institute, Sarasota, FL, 34243, USA.; James A. Haley Veterans' Hospital, Tampa, FL, USA.; The Open University, Milton Keynes, UK.
Bachmeier C; Department of Experimental Neuropathology, Roskamp Institute, Sarasota, FL, 34243, USA.; The Open University, Milton Keynes, UK.; Bay Pines VA Healthcare System, Bay Pines, FL, USA.; Pokaż więcej
Źródło:: Molecular brain [Mol Brain] 2021 Jul 08; Vol. 14 (1), pp. 110. Date of Electronic Publication: 2021 Jul 08.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:: Genetic Predisposition to Disease*
Aging/*pathology
Alzheimer Disease/*genetics
Apolipoproteins E/*genetics
Brain/*blood supply
Brain/*pathology
Dementia/*genetics
Aged ; Aged, 80 and over ; Alzheimer Disease/pathology ; Case-Control Studies ; Female ; Humans ; Male ; Middle Aged ; Organ Size ; Proteome/metabolism ; Proteomics ; Subcellular Fractions/metabolism

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Tytuł:: ABCA1 haplodeficiency affects the brain transcriptome following traumatic brain injury in mice expressing human APOE isoforms.
Autorzy:: Castranio EL; Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
Wolfe CM; Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
Nam KN; Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
Letronne F; Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
Fitz NF; Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
Lefterov I; Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA, 15261, USA. .
Koldamova R; Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA, 15261, USA. .; Pokaż więcej
Źródło:: Acta neuropathologica communications [Acta Neuropathol Commun] 2018 Jul 26; Vol. 6 (1), pp. 69. Date of Electronic Publication: 2018 Jul 26.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:: ATP Binding Cassette Transporter 1/*deficiency
Apolipoproteins E/*metabolism
Brain/*metabolism
Brain Injuries, Traumatic/*genetics
Brain Injuries, Traumatic/*pathology
Gene Expression Regulation/*genetics
ATP Binding Cassette Transporter 1/genetics ; Animals ; Apolipoproteins E/genetics ; Brain Injuries, Traumatic/metabolism ; Disease Models, Animal ; Gene Regulatory Networks ; Humans ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Microglia/metabolism ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism

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Skocz do pozycji: 10.

Tytuł:: Functional genomic analyses uncover APOE-mediated regulation of brain and cerebrospinal fluid beta-amyloid levels in Parkinson disease.
Autorzy:: Ibanez L; Department of Psychiatry, BJC Institute of Health, Washington University School of Medicine, Box 8134, 425 S. Euclid Ave., St. Louis, MO, 63110, USA.; NeuroGenomics and Informatics Center, Washington University, St. Louis, MO, 63110, USA.
Bahena JA; Department of Psychiatry, BJC Institute of Health, Washington University School of Medicine, Box 8134, 425 S. Euclid Ave., St. Louis, MO, 63110, USA.; NeuroGenomics and Informatics Center, Washington University, St. Louis, MO, 63110, USA.
Yang C; Department of Psychiatry, BJC Institute of Health, Washington University School of Medicine, Box 8134, 425 S. Euclid Ave., St. Louis, MO, 63110, USA.; NeuroGenomics and Informatics Center, Washington University, St. Louis, MO, 63110, USA.
Dube U; Department of Psychiatry, BJC Institute of Health, Washington University School of Medicine, Box 8134, 425 S. Euclid Ave., St. Louis, MO, 63110, USA.; NeuroGenomics and Informatics Center, Washington University, St. Louis, MO, 63110, USA.
Farias FHG; Department of Psychiatry, BJC Institute of Health, Washington University School of Medicine, Box 8134, 425 S. Euclid Ave., St. Louis, MO, 63110, USA.; NeuroGenomics and Informatics Center, Washington University, St. Louis, MO, 63110, USA.
Budde JP; Department of Psychiatry, BJC Institute of Health, Washington University School of Medicine, Box 8134, 425 S. Euclid Ave., St. Louis, MO, 63110, USA.; NeuroGenomics and Informatics Center, Washington University, St. Louis, MO, 63110, USA.
Bergmann K; Department of Psychiatry, BJC Institute of Health, Washington University School of Medicine, Box 8134, 425 S. Euclid Ave., St. Louis, MO, 63110, USA.; NeuroGenomics and Informatics Center, Washington University, St. Louis, MO, 63110, USA.
Brenner-Webster C; Department of Psychiatry, BJC Institute of Health, Washington University School of Medicine, Box 8134, 425 S. Euclid Ave., St. Louis, MO, 63110, USA.; NeuroGenomics and Informatics Center, Washington University, St. Louis, MO, 63110, USA.
Morris JC; Hope Center for Neurologic Disorders, Washington University, St. Louis, MO, 63110, USA.; Department of Neurology, Washington University, St. Louis, MO, 63110, USA.; The Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Perrin RJ; Hope Center for Neurologic Disorders, Washington University, St. Louis, MO, 63110, USA.; Department of Neurology, Washington University, St. Louis, MO, 63110, USA.; The Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO, 63110, USA.; Department of Pathology and Immunology, Washington University, St. Louis, MO, 63110, USA.
Cairns NJ; Hope Center for Neurologic Disorders, Washington University, St. Louis, MO, 63110, USA.; Department of Neurology, Washington University, St. Louis, MO, 63110, USA.; The Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO, 63110, USA.; Department of Pathology and Immunology, Washington University, St. Louis, MO, 63110, USA.; College of Medicine and Health, University of Exeter, Exeter, Devon, UK.
O'Donnell J; Department of Neurology, Washington University, St. Louis, MO, 63110, USA.
Álvarez I; Memory Unit, Department of Neurology, University Hospital Mutua de Terrassa, University of Barcelona, Terrassa, Barcelona, Spain.; Fundació per a la Recerca Biomèdica i Social Mútua de Terrassa, University of Barcelona, Terrassa, Barcelona, Spain.
Diez-Fairen M; Memory Unit, Department of Neurology, University Hospital Mutua de Terrassa, University of Barcelona, Terrassa, Barcelona, Spain.; Fundació per a la Recerca Biomèdica i Social Mútua de Terrassa, University of Barcelona, Terrassa, Barcelona, Spain.
Aguilar M; Memory Unit, Department of Neurology, University Hospital Mutua de Terrassa, University of Barcelona, Terrassa, Barcelona, Spain.; Fundació per a la Recerca Biomèdica i Social Mútua de Terrassa, University of Barcelona, Terrassa, Barcelona, Spain.
Miller R; Department of Neurology, Washington University, St. Louis, MO, 63110, USA.
Davis AA; Hope Center for Neurologic Disorders, Washington University, St. Louis, MO, 63110, USA.; Department of Neurology, Washington University, St. Louis, MO, 63110, USA.
Pastor P; Memory Unit, Department of Neurology, University Hospital Mutua de Terrassa, University of Barcelona, Terrassa, Barcelona, Spain.; Fundació per a la Recerca Biomèdica i Social Mútua de Terrassa, University of Barcelona, Terrassa, Barcelona, Spain.
Kotzbauer P; Hope Center for Neurologic Disorders, Washington University, St. Louis, MO, 63110, USA.; Department of Neurology, Washington University, St. Louis, MO, 63110, USA.
Campbell MC; Department of Neurology, Washington University, St. Louis, MO, 63110, USA.; Departments of Neuroscience and Radiology, Programs in Physical Therapy and Occupational Therapy, Washington University, St. Louis, MO, 63110, USA.
Perlmutter JS; Hope Center for Neurologic Disorders, Washington University, St. Louis, MO, 63110, USA.; Department of Neurology, Washington University, St. Louis, MO, 63110, USA.; Departments of Neuroscience and Radiology, Programs in Physical Therapy and Occupational Therapy, Washington University, St. Louis, MO, 63110, USA.
Rhinn H; Department of Bioinformatics, Alector, INC, San Francisco, CA, 94080, USA.
Harari O; Department of Psychiatry, BJC Institute of Health, Washington University School of Medicine, Box 8134, 425 S. Euclid Ave., St. Louis, MO, 63110, USA.; NeuroGenomics and Informatics Center, Washington University, St. Louis, MO, 63110, USA.; Hope Center for Neurologic Disorders, Washington University, St. Louis, MO, 63110, USA.; The Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Cruchaga C; Department of Psychiatry, BJC Institute of Health, Washington University School of Medicine, Box 8134, 425 S. Euclid Ave., St. Louis, MO, 63110, USA.; NeuroGenomics and Informatics Center, Washington University, St. Louis, MO, 63110, USA.; Hope Center for Neurologic Disorders, Washington University, St. Louis, MO, 63110, USA.; The Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO, 63110, USA.; Department of Genetics, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Benitez BA; Department of Psychiatry, BJC Institute of Health, Washington University School of Medicine, Box 8134, 425 S. Euclid Ave., St. Louis, MO, 63110, USA. .; NeuroGenomics and Informatics Center, Washington University, St. Louis, MO, 63110, USA. .; Pokaż więcej
Źródło:: Acta neuropathologica communications [Acta Neuropathol Commun] 2020 Nov 19; Vol. 8 (1), pp. 196. Date of Electronic Publication: 2020 Nov 19.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Amyloid beta-Peptides/*metabolism
Apolipoproteins E/*genetics
Brain/*metabolism
Parkinson Disease/*genetics
Peptide Fragments/*metabolism
Aged ; Aged, 80 and over ; Amyloid beta-Peptides/cerebrospinal fluid ; Apolipoprotein E4/genetics ; Female ; Genome-Wide Association Study ; Humans ; Male ; Mendelian Randomization Analysis ; Middle Aged ; Parkinson Disease/metabolism ; Peptide Fragments/cerebrospinal fluid ; Phosphorylation ; alpha-Synuclein/cerebrospinal fluid ; alpha-Synuclein/metabolism ; tau Proteins/cerebrospinal fluid ; tau Proteins/metabolism

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Tytuł:: The lipid phosphatase Synaptojanin 1 undergoes a significant alteration in expression and solubility and is associated with brain lesions in Alzheimer's disease.
Autorzy:: Ando K; Laboratory of Histology, Neuroanatomy and Neuropathology, ULB Neuroscience Institute, Université Libre de Bruxelles (ULB), 808, route de Lennik (Bldg G), 1070, Brussels, Belgium. .; Laboratoire de Neuropathologie Escourolle, Hôpital de la Pitié-Salpêtrière, AP-HP, Paris, France. .; ICM Institut du Cerveau, CNRS UMR7225, INSERM U1127, UPMC, Hôpital de la Pitié-Salpêtrière, Paris, France. .
Ndjim M; ICM Institut du Cerveau, CNRS UMR7225, INSERM U1127, UPMC, Hôpital de la Pitié-Salpêtrière, Paris, France.
Turbant S; Laboratoire de Neuropathologie Escourolle, Hôpital de la Pitié-Salpêtrière, AP-HP, Paris, France.; ICM Institut du Cerveau, CNRS UMR7225, INSERM U1127, UPMC, Hôpital de la Pitié-Salpêtrière, Paris, France.
Fontaine G; ICM Institut du Cerveau, CNRS UMR7225, INSERM U1127, UPMC, Hôpital de la Pitié-Salpêtrière, Paris, France.
Pregoni G; ICM Institut du Cerveau, CNRS UMR7225, INSERM U1127, UPMC, Hôpital de la Pitié-Salpêtrière, Paris, France.
Dauphinot L; ICM Institut du Cerveau, CNRS UMR7225, INSERM U1127, UPMC, Hôpital de la Pitié-Salpêtrière, Paris, France.
Yilmaz Z; Laboratory of Histology, Neuroanatomy and Neuropathology, ULB Neuroscience Institute, Université Libre de Bruxelles (ULB), 808, route de Lennik (Bldg G), 1070, Brussels, Belgium.
Suain V; Laboratory of Histology, Neuroanatomy and Neuropathology, ULB Neuroscience Institute, Université Libre de Bruxelles (ULB), 808, route de Lennik (Bldg G), 1070, Brussels, Belgium.
Mansour S; Laboratory of Histology, Neuroanatomy and Neuropathology, ULB Neuroscience Institute, Université Libre de Bruxelles (ULB), 808, route de Lennik (Bldg G), 1070, Brussels, Belgium.
Authelet M; Laboratory of Histology, Neuroanatomy and Neuropathology, ULB Neuroscience Institute, Université Libre de Bruxelles (ULB), 808, route de Lennik (Bldg G), 1070, Brussels, Belgium.
De Dekker R; Laboratory of Histology, Neuroanatomy and Neuropathology, ULB Neuroscience Institute, Université Libre de Bruxelles (ULB), 808, route de Lennik (Bldg G), 1070, Brussels, Belgium.
Leroy K; Laboratory of Histology, Neuroanatomy and Neuropathology, ULB Neuroscience Institute, Université Libre de Bruxelles (ULB), 808, route de Lennik (Bldg G), 1070, Brussels, Belgium.
Delatour B; ICM Institut du Cerveau, CNRS UMR7225, INSERM U1127, UPMC, Hôpital de la Pitié-Salpêtrière, Paris, France.
Duyckaerts C; Laboratoire de Neuropathologie Escourolle, Hôpital de la Pitié-Salpêtrière, AP-HP, Paris, France.; ICM Institut du Cerveau, CNRS UMR7225, INSERM U1127, UPMC, Hôpital de la Pitié-Salpêtrière, Paris, France.
Potier MC; ICM Institut du Cerveau, CNRS UMR7225, INSERM U1127, UPMC, Hôpital de la Pitié-Salpêtrière, Paris, France.
Brion JP; Laboratory of Histology, Neuroanatomy and Neuropathology, ULB Neuroscience Institute, Université Libre de Bruxelles (ULB), 808, route de Lennik (Bldg G), 1070, Brussels, Belgium. .; Pokaż więcej
Corporate Authors:: Brain Bank NeuroCEB Neuropathology Network
Źródło:: Acta neuropathologica communications [Acta Neuropathol Commun] 2020 Jun 03; Vol. 8 (1), pp. 79. Date of Electronic Publication: 2020 Jun 03.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Alzheimer Disease/*metabolism
Alzheimer Disease/*pathology
Brain/*pathology
Phosphoric Monoester Hydrolases/*metabolism
Protein Aggregation, Pathological/*pathology
Aged ; Apolipoproteins E/genetics ; Brain/metabolism ; Calpain/metabolism ; HEK293 Cells ; Humans ; Neurons/metabolism ; Neurons/pathology ; tau Proteins/metabolism

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Skocz do pozycji: 12.

Tytuł:: ERβ and ApoE isoforms interact to regulate BDNF-5-HT 2A signaling and synaptic function in the female brain.
Autorzy:: Chhibber A; Department of Pharmacology and Toxicology, School of Pharmacy, University of Kansas, 1251 Wescoe Hall Drive, Malott Hall Room 2046, Lawrence, KS, 66045, USA.
Zhao L; Department of Pharmacology and Toxicology, School of Pharmacy, University of Kansas, 1251 Wescoe Hall Drive, Malott Hall Room 2046, Lawrence, KS, 66045, USA. .; Neuroscience Graduate Program, University of Kansas, Lawrence, KS, USA. .; Pokaż więcej
Źródło:: Alzheimer's research & therapy [Alzheimers Res Ther] 2017 Sep 21; Vol. 9 (1), pp. 79. Date of Electronic Publication: 2017 Sep 21.
Typ publikacji:: Journal Article
MeSH Terms:: Apolipoproteins E/*metabolism
Brain/*metabolism
Brain-Derived Neurotrophic Factor/*metabolism
Estrogen Receptor beta/*metabolism
Protein Isoforms/*metabolism
Receptor, Serotonin, 5-HT2A/*metabolism
Synapses/*physiology
Animals ; Apolipoproteins E/genetics ; Brain/drug effects ; Disks Large Homolog 4 Protein/genetics ; Disks Large Homolog 4 Protein/metabolism ; Estrogen Receptor beta/genetics ; Female ; Gene Expression Regulation/drug effects ; Gene Expression Regulation/genetics ; Humans ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Microfilament Proteins ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/metabolism ; Protein Isoforms/genetics ; Selective Estrogen Receptor Modulators/pharmacology ; Signal Transduction/drug effects ; Signal Transduction/physiology ; Synaptophysin/genetics ; Synaptophysin/metabolism ; Vesicle-Associated Membrane Protein 2/genetics ; Vesicle-Associated Membrane Protein 2/metabolism

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Tytuł:: Exploring Alzheimer's Disease Molecular Variability via Calculation of Personalized Transcriptional Signatures.
Autorzy:: Dagan H; The Rachel and Selim Benin School of Computer Science and Engineering, Hebrew University, Jerusalem 9190416, Israel.
Flashner-Abramson E; Department for Bio-medical Research, Faculty of Dental Medicine, Hebrew University of Jerusalem, Jerusalem 91120, Israel.
Vasudevan S; Department for Bio-medical Research, Faculty of Dental Medicine, Hebrew University of Jerusalem, Jerusalem 91120, Israel.
Jubran MR; Department for Bio-medical Research, Faculty of Dental Medicine, Hebrew University of Jerusalem, Jerusalem 91120, Israel.
Cohen E; Department of Biochemistry and Molecular Biology, The Institute for Medical Research Israel - Canada, The Hebrew University School of Medicine, Jerusalem 9112102, Israel.
Kravchenko-Balasha N; Department for Bio-medical Research, Faculty of Dental Medicine, Hebrew University of Jerusalem, Jerusalem 91120, Israel.; Pokaż więcej
Źródło:: Biomolecules [Biomolecules] 2020 Mar 26; Vol. 10 (4). Date of Electronic Publication: 2020 Mar 26.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Alzheimer Disease/*genetics
Brain/*physiopathology
Transcriptome/*genetics
Aged ; Aged, 80 and over ; Alzheimer Disease/physiopathology ; Apolipoproteins E/genetics ; Calcium Signaling/genetics ; Case-Control Studies ; Databases, Genetic ; Humans ; Middle Aged ; Precision Medicine/methods ; Reproducibility of Results

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Skocz do pozycji: 14.

Tytuł:: Evidence in support of chromosomal sex influencing plasma based metabolome vs APOE genotype influencing brain metabolome profile in humanized APOE male and female mice.
Autorzy:: Shang Y; Center for Innovation in Brain Science, University of Arizona, Tucson, Arizona, United States of America.
Mishra A; Center for Innovation in Brain Science, University of Arizona, Tucson, Arizona, United States of America.
Wang T; Center for Innovation in Brain Science, University of Arizona, Tucson, Arizona, United States of America.
Wang Y; Center for Innovation in Brain Science, University of Arizona, Tucson, Arizona, United States of America.
Desai M; School of Pharmacy, University of Southern California, Los Angeles, California, United States of America.
Chen S; Center for Innovation in Brain Science, University of Arizona, Tucson, Arizona, United States of America.
Mao Z; Center for Innovation in Brain Science, University of Arizona, Tucson, Arizona, United States of America.
Do L; Biomedical Engineering, University of Arizona, Tucson, Arizona, United States of America.
Bernstein AS; College of Medicine, University of Arizona, Tucson, Arizona, United States of America.
Trouard TP; Biomedical Engineering, University of Arizona, Tucson, Arizona, United States of America.
Brinton RD; Center for Innovation in Brain Science, University of Arizona, Tucson, Arizona, United States of America.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2020 Jan 09; Vol. 15 (1), pp. e0225392. Date of Electronic Publication: 2020 Jan 09 (Print Publication: 2020).
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Alzheimer Disease/*genetics
Apolipoprotein E4/*genetics
Apolipoproteins E/*genetics
Brain/*metabolism
Age of Onset ; Aging/genetics ; Aging/metabolism ; Aging/pathology ; Alzheimer Disease/diagnostic imaging ; Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Amyloid beta-Peptides/genetics ; Amyloid beta-Peptides/metabolism ; Animals ; Brain/diagnostic imaging ; Brain/pathology ; Disease Models, Animal ; Female ; Genotype ; Humans ; Magnetic Resonance Imaging ; Male ; Metabolome/genetics ; Mice ; Mice, Transgenic ; Sex Characteristics ; Sex Chromosomes/genetics ; Sex Chromosomes/metabolism

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Skocz do pozycji: 15.

Tytuł:: Plasma amyloid assay as a pre-screening tool for amyloid positron emission tomography imaging in early stage Alzheimer's disease.
Autorzy:: Lin SY; Department of Neurology, Taipei Municipal Gan-Dau Hospital, Taipei, Taiwan.
Lin KJ; Department of Nuclear Medicine and Molecular Imaging Center, Linkou Chang Gung Memorial Hospital, Tao-Yuan, Taiwan. .; Healthy Aging Research Center and Department of Medical Imaging and Radiological Sciences, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan. .
Lin PC; Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.
Huang CC; Department of Neurology, Linkou Chang Gung Memorial Hospital and University, Tao-Yuan, Taiwan.
Chang CC; Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
Lee YC; Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.; Department of Neurology, School of Medicine, National Yang-Ming University, Taipei, Taiwan.; Brain Research Center, National Yang-Ming University, Taipei, Taiwan.
Hsiao IT; Department of Nuclear Medicine and Molecular Imaging Center, Linkou Chang Gung Memorial Hospital, Tao-Yuan, Taiwan.; Healthy Aging Research Center and Department of Medical Imaging and Radiological Sciences, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan.
Yen TC; Department of Nuclear Medicine and Molecular Imaging Center, Linkou Chang Gung Memorial Hospital, Tao-Yuan, Taiwan.; Healthy Aging Research Center and Department of Medical Imaging and Radiological Sciences, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan.
Huang WS; Department of Nuclear Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
Yang BH; Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan.
Wang PN; Department of Neurology, School of Medicine, National Yang-Ming University, Taipei, Taiwan. .; Brain Research Center, National Yang-Ming University, Taipei, Taiwan. .; Aging and Health Research Center, National Yang-Ming University, Taipei, Taiwan. .; Division of General Neurology, Department of Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan. .; Pokaż więcej
Źródło:: Alzheimer's research & therapy [Alzheimers Res Ther] 2019 Dec 27; Vol. 11 (1), pp. 111. Date of Electronic Publication: 2019 Dec 27.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Alzheimer Disease/*diagnosis
Amyloid beta-Peptides/*blood
Brain/*metabolism
Cognitive Dysfunction/*diagnosis
Peptide Fragments/*blood
Aged ; Aged, 80 and over ; Alzheimer Disease/blood ; Alzheimer Disease/diagnostic imaging ; Apolipoproteins E/genetics ; Brain/diagnostic imaging ; Cognitive Dysfunction/blood ; Cognitive Dysfunction/diagnostic imaging ; Female ; Genotype ; Humans ; Male ; Middle Aged ; Positron-Emission Tomography ; tau Proteins/blood

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Skocz do pozycji: 16.

Tytuł:: Comparative profiling of the synaptic proteome from Alzheimer's disease patients with focus on the APOE genotype.
Autorzy:: Hesse R; Centre for Discovery Brain Sciences, UK Dementia Research Institute, The University of Edinburgh, 1 George Square, Edinburgh, EH8 9JZ, Scotland, UK.
Hurtado ML; College of Medicine and Veterinary Medicine, The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, Scotland, UK.
Jackson RJ; Centre for Discovery Brain Sciences, UK Dementia Research Institute, The University of Edinburgh, 1 George Square, Edinburgh, EH8 9JZ, Scotland, UK.
Eaton SL; College of Medicine and Veterinary Medicine, The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, Scotland, UK.
Herrmann AG; Centre for Discovery Brain Sciences, UK Dementia Research Institute, The University of Edinburgh, 1 George Square, Edinburgh, EH8 9JZ, Scotland, UK.
Colom-Cadena M; Centre for Discovery Brain Sciences, UK Dementia Research Institute, The University of Edinburgh, 1 George Square, Edinburgh, EH8 9JZ, Scotland, UK.
Tzioras M; Centre for Discovery Brain Sciences, UK Dementia Research Institute, The University of Edinburgh, 1 George Square, Edinburgh, EH8 9JZ, Scotland, UK.
King D; Centre for Discovery Brain Sciences, UK Dementia Research Institute, The University of Edinburgh, 1 George Square, Edinburgh, EH8 9JZ, Scotland, UK.
Rose J; Centre for Discovery Brain Sciences, UK Dementia Research Institute, The University of Edinburgh, 1 George Square, Edinburgh, EH8 9JZ, Scotland, UK.
Tulloch J; Centre for Discovery Brain Sciences, UK Dementia Research Institute, The University of Edinburgh, 1 George Square, Edinburgh, EH8 9JZ, Scotland, UK.
McKenzie CA; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, Scotland, UK.
Smith C; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, Scotland, UK.
Henstridge CM; Centre for Discovery Brain Sciences, UK Dementia Research Institute, The University of Edinburgh, 1 George Square, Edinburgh, EH8 9JZ, Scotland, UK.; Division of Systems Medicine, Neuroscience, Ninewells Hospital & Medical School, University of Dundee, Dundee, UK.
Lamont D; FingerPrints Proteomics Facility, College of Life Sciences, University of Dundee, Dundee, Scotland, UK.
Wishart TM; College of Medicine and Veterinary Medicine, The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, Scotland, UK. .
Spires-Jones TL; Centre for Discovery Brain Sciences, UK Dementia Research Institute, The University of Edinburgh, 1 George Square, Edinburgh, EH8 9JZ, Scotland, UK. .; Pokaż więcej
Źródło:: Acta neuropathologica communications [Acta Neuropathol Commun] 2019 Dec 20; Vol. 7 (1), pp. 214. Date of Electronic Publication: 2019 Dec 20.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Proteome*
Alzheimer Disease/*metabolism
Apolipoproteins E/*metabolism
Brain/*metabolism
Neurons/*metabolism
Synapses/*metabolism
Adult ; Aged, 80 and over ; Alzheimer Disease/pathology ; Apolipoprotein E4/metabolism ; Brain/pathology ; Female ; Humans ; Male ; Middle Aged ; Mitochondria/metabolism ; Neurons/pathology ; Proteomics ; Synapses/pathology

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Skocz do pozycji: 17.

Tytuł:: ABCA7 polymorphisms correlate with memory impairment and default mode network in patients with APOEε4-associated Alzheimer's disease.
Autorzy:: Chang YT; Department of Neurology, Institute of translational research in biomedicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 123, Ta-Pei Road, Niaosung, Kaohsiung, 833, Taiwan. .
Hsu SW; Department of Radiology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 123, Ta-Pei Road, Niaosung, Kaohsiung, 833, Taiwan.
Huang SH; Department of Nuclear Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 123, Ta-Pei Road, Niaosung, Kaohsiung, 833, Taiwan.
Huang CW; Department of Neurology, Institute of translational research in biomedicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 123, Ta-Pei Road, Niaosung, Kaohsiung, 833, Taiwan.
Chang WN; Department of Neurology, Institute of translational research in biomedicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 123, Ta-Pei Road, Niaosung, Kaohsiung, 833, Taiwan.
Lien CY; Department of Neurology, Institute of translational research in biomedicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 123, Ta-Pei Road, Niaosung, Kaohsiung, 833, Taiwan.
Lee JJ; Department of Neurology, Institute of translational research in biomedicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 123, Ta-Pei Road, Niaosung, Kaohsiung, 833, Taiwan.
Lee CC; Department of Radiology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 123, Ta-Pei Road, Niaosung, Kaohsiung, 833, Taiwan.
Chang CC; Department of Neurology, Institute of translational research in biomedicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 123, Ta-Pei Road, Niaosung, Kaohsiung, 833, Taiwan. .; Pokaż więcej
Źródło:: Alzheimer's research & therapy [Alzheimers Res Ther] 2019 Dec 12; Vol. 11 (1), pp. 103. Date of Electronic Publication: 2019 Dec 12.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: ATP-Binding Cassette Transporters/*genetics
Alzheimer Disease/*genetics
Apolipoproteins E/*genetics
Brain/*diagnostic imaging
Memory Disorders/*genetics
Nerve Net/*diagnostic imaging
Aged ; Aged, 80 and over ; Alleles ; Alzheimer Disease/diagnostic imaging ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Memory Disorders/diagnostic imaging ; Middle Aged ; Neuroimaging ; Neuropsychological Tests ; Polymorphism, Single Nucleotide

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Skocz do pozycji: 18.

Tytuł:: Lack of hepatic apoE does not influence early Aβ deposition: observations from a new APOE knock-in model.
Autorzy:: Huynh TV; Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA.; Medical Scientist Training Program (MSTP), Washington University School of Medicine, St. Louis, MO, USA.
Wang C; Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA.
Tran AC; Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA.
Tabor GT; Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA.; Medical Scientist Training Program (MSTP), Washington University School of Medicine, St. Louis, MO, USA.
Mahan TE; Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA.
Francis CM; Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA.
Finn MB; Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA.
Spellman R; Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA.
Manis M; Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA.
Tanzi RE; McCance Center for Brain Health and Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.
Ulrich JD; Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA.
Holtzman DM; Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA. .; Pokaż więcej
Źródło:: Molecular neurodegeneration [Mol Neurodegener] 2019 Oct 17; Vol. 14 (1), pp. 37. Date of Electronic Publication: 2019 Oct 17.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Alzheimer Disease/*metabolism
Amyloid beta-Protein Precursor/*metabolism
Apolipoproteins E/*genetics
Brain/*metabolism
Amyloid beta-Peptides/metabolism ; Animals ; Astrocytes/metabolism ; Cerebral Amyloid Angiopathy/metabolism ; Cerebral Amyloid Angiopathy/pathology ; Disease Models, Animal ; Mice, Transgenic ; Microglia/metabolism ; Plaque, Amyloid/pathology

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Skocz do pozycji: 19.

Tytuł:: The Alzheimer's disease risk factors apolipoprotein E and TREM2 are linked in a receptor signaling pathway.
Autorzy:: Jendresen C; Department of Pharmacology, Institute of Clinical Medicine, University of Oslo and Oslo University Hospital, Postboks 1057 Blindern, 0316, Oslo, Norway.
Årskog V; Department of Pharmacology, Institute of Clinical Medicine, University of Oslo and Oslo University Hospital, Postboks 1057 Blindern, 0316, Oslo, Norway.
Daws MR; Division of Anatomy, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Nilsson LN; Department of Pharmacology, Institute of Clinical Medicine, University of Oslo and Oslo University Hospital, Postboks 1057 Blindern, 0316, Oslo, Norway. .; Pokaż więcej
Źródło:: Journal of neuroinflammation [J Neuroinflammation] 2017 Mar 21; Vol. 14 (1), pp. 59. Date of Electronic Publication: 2017 Mar 21.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Alzheimer Disease/*physiopathology
Apolipoproteins E/*metabolism
Brain/*metabolism
Membrane Glycoproteins/*metabolism
Receptors, Immunologic/*metabolism
Signal Transduction/*genetics
Age Factors ; Alzheimer Disease/genetics ; Amyloid beta-Protein Precursor/genetics ; Animals ; Apolipoproteins E/genetics ; Cell Line, Transformed ; Humans ; Membrane Glycoproteins/genetics ; Mice ; Mice, Transgenic ; Models, Biological ; Models, Molecular ; Protein Array Analysis ; Protein Binding/genetics ; Protein Domains/physiology ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Receptors, Immunologic/genetics ; Risk Factors ; T-Lymphocytes/metabolism

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Skocz do pozycji: 20.

Tytuł:: Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation.
Autorzy:: Achariyar TM; Center for Translational Neuromedicine, Division of Glial Disease and Therapeutics, Department of Neurosurgery, University of Rochester Medical Center, University of Rochester, Rochester, NY, 14642, USA.
Li B; Center for Translational Neuromedicine, Division of Glial Disease and Therapeutics, Department of Neurosurgery, University of Rochester Medical Center, University of Rochester, Rochester, NY, 14642, USA.; Laboratory of Brain Metabolic Diseases, Institute of Metabolic Disease Research and Drug Development, China Medical University, Shenyang, China.
Peng W; Center for Translational Neuromedicine, Division of Glial Disease and Therapeutics, Department of Neurosurgery, University of Rochester Medical Center, University of Rochester, Rochester, NY, 14642, USA.
Verghese PB; Department of Neurology, Hope Center for Neurological Disorders, and the Charles F. and Joanne Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St Louis, MO, 63110, USA.
Shi Y; Department of Neurology, Hope Center for Neurological Disorders, and the Charles F. and Joanne Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St Louis, MO, 63110, USA.
McConnell E; Center for Translational Neuromedicine, Division of Glial Disease and Therapeutics, Department of Neurosurgery, University of Rochester Medical Center, University of Rochester, Rochester, NY, 14642, USA.
Benraiss A; Center for Translational Neuromedicine, Division of Cell and Gene Therapy, University of Rochester Medical Center, Rochester, NY, 14642, USA.
Kasper T; Center for Translational Neuromedicine, Division of Glial Disease and Therapeutics, Department of Neurosurgery, University of Rochester Medical Center, University of Rochester, Rochester, NY, 14642, USA.
Song W; Center for Translational Neuromedicine, Division of Glial Disease and Therapeutics, Department of Neurosurgery, University of Rochester Medical Center, University of Rochester, Rochester, NY, 14642, USA.
Takano T; Center for Translational Neuromedicine, Division of Glial Disease and Therapeutics, Department of Neurosurgery, University of Rochester Medical Center, University of Rochester, Rochester, NY, 14642, USA.
Holtzman DM; Department of Neurology, Hope Center for Neurological Disorders, and the Charles F. and Joanne Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St Louis, MO, 63110, USA.
Nedergaard M; Center for Translational Neuromedicine, Division of Glial Disease and Therapeutics, Department of Neurosurgery, University of Rochester Medical Center, University of Rochester, Rochester, NY, 14642, USA.
Deane R; Center for Translational Neuromedicine, Division of Glial Disease and Therapeutics, Department of Neurosurgery, University of Rochester Medical Center, University of Rochester, Rochester, NY, 14642, USA. Rashid_.; Pokaż więcej
Źródło:: Molecular neurodegeneration [Mol Neurodegener] 2016 Dec 08; Vol. 11 (1), pp. 74. Date of Electronic Publication: 2016 Dec 08.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:: Alzheimer Disease/*metabolism
Apolipoproteins E/*metabolism
Brain/*metabolism
Neurons/*metabolism
Sleep Deprivation/*metabolism
Animals ; Apolipoproteins E/cerebrospinal fluid ; Aquaporin 4/metabolism ; Biological Transport ; Male ; Mice ; Protein Isoforms/metabolism ; Sleep Deprivation/cerebrospinal fluid ; Time Factors

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