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Wyszukujesz frazę ""Apoptosis"" wg kryterium: Temat


Starter badań:

Tytuł :
CSC-3436 sensitizes triple negative breast cancer cells to TRAIL-induced apoptosis through ROS-mediated p38/CHOP/death receptor 5 signaling pathways.
Autorzy :
Huang CC; Department of Biological Science and Technology, College of Life Sciences, China Medical University, Taichung, Taiwan.
Cheng YC; Department of Biological Science and Technology, College of Life Sciences, China Medical University, Taichung, Taiwan.
Lin YC; Division of Neurosurgery, Buddhist Tzu Chi General Hospital, Taichung Branch, Taichung, Taiwan.; School of Medicine, Tzu Chi University, Hualien, Taiwan.; Department of Medical Imaging and Radiological Science, Central Taiwan University of Science and Technology, Taichung, Taiwan.
Chou CH; Ph.D. Program for Biotechnology Industry, College of Life Sciences, China Medical University, Taichung, Taiwan.
Ho CT; Department of Food Science, Rutgers University, New Brunswick, New Jersey, USA.
Wang HK; Department of Neurosurgery, E-Da Hospital/I-Shou University, Kaohsiung, Taiwan.; School of Medicine, I-Shou University, Kaohsiung, Taiwan.
Way TD; Department of Biological Science and Technology, College of Life Sciences, China Medical University, Taichung, Taiwan.; Ph.D. Program for Biotechnology Industry, College of Life Sciences, China Medical University, Taichung, Taiwan.; Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan.
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Źródło :
Environmental toxicology [Environ Toxicol] 2021 Dec; Vol. 36 (12), pp. 2578-2588. Date of Electronic Publication: 2021 Oct 02.
Typ publikacji :
Journal Article
MeSH Terms :
Receptors, TNF-Related Apoptosis-Inducing Ligand*/genetics
Triple Negative Breast Neoplasms*
Apoptosis ; Cell Line, Tumor ; Humans ; Ligands ; Naphthyridines ; Reactive Oxygen Species ; TNF-Related Apoptosis-Inducing Ligand ; Transcription Factor CHOP/genetics
Czasopismo naukowe
Tytuł :
Selective killing of human M1 macrophages by Smac mimetics alone and M2 macrophages by Smac mimetics and caspase inhibition.
Autorzy :
Ali H; Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON, Canada.; Apoptosis Research Centre, Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada.
Caballero R; Apoptosis Research Centre, Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada.
Dong SXM; Apoptosis Research Centre, Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada.
Gajnayaka N; Apoptosis Research Centre, Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada.
Vranjkovic A; Chronic Disease Program, The Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Ahmed D; Department of Biology, Carleton University, Ottawa, ON, Canada.
Iqbal S; Apoptosis Research Centre, Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada.
Crawley AM; Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON, Canada.; Department of Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; Chronic Disease Program, The Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Biology, Carleton University, Ottawa, ON, Canada.
Angel JB; Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON, Canada.; Department of Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; Chronic Disease Program, The Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Cassol E; Department of Health Sciences, Carleton University, Ottawa, ON, Canada.
Kumar A; Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON, Canada.; Department of Pathology and Laboratory Medicine, University of Ottawa, Ottawa, ON, Canada.; Apoptosis Research Centre, Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada.
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Źródło :
Journal of leukocyte biology [J Leukoc Biol] 2021 Oct; Vol. 110 (4), pp. 693-710. Date of Electronic Publication: 2021 Jan 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*/drug effects
Cell Polarity*/drug effects
Caspase Inhibitors/*pharmacology
Macrophages/*cytology
Oligopeptides/*pharmacology
Animals ; Biomarkers/metabolism ; Cell Differentiation/drug effects ; Cell Membrane/drug effects ; Cell Membrane/metabolism ; Cytokines/metabolism ; Humans ; Inflammation Mediators/metabolism ; Inhibitor of Apoptosis Proteins/metabolism ; Janus Kinases/metabolism ; Kinetics ; Macrophage Activation/drug effects ; Macrophages/drug effects ; Mice ; Necroptosis/drug effects ; Phenotype ; STAT Transcription Factors/metabolism ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
Phenylboronic acid modified lipid nanocarriers mediated co-delivery of immunocytokine TRAIL and gamma-secretase inhibitor to triple negative breast cancer cells and cancer stem cells.
Autorzy :
Pindiprolu SKSS; Department of Pharmacology, Aditya Pharmacy College, Surampalem, India. Electronic address: .
Avasarala H; Department of Pharmaceutics, Aditya College of Pharmacy, Surampalem, India.
Dinakaran SK; Department of Pharmaceutical Analysis, Aditya Pharmacy College, Surampalem, India.
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Źródło :
Medical hypotheses [Med Hypotheses] 2021 Dec; Vol. 157, pp. 110716. Date of Electronic Publication: 2021 Oct 20.
Typ publikacji :
Letter
MeSH Terms :
TNF-Related Apoptosis-Inducing Ligand*
Triple Negative Breast Neoplasms*/drug therapy
Amyloid Precursor Protein Secretases ; Apoptosis ; Boronic Acids ; Cell Line, Tumor ; Humans ; Lipids ; Neoplasm Recurrence, Local ; Neoplastic Stem Cells
Opinia redakcyjna
Tytuł :
The anti-apoptotic Bcl-2 protein regulates hair follicle stem cell function.
Autorzy :
Geueke A; Center for Molecular Medicine Cologne (CMMC), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Centre of Biochemistry, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Mantellato G; Center for Molecular Medicine Cologne (CMMC), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Centre of Biochemistry, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Kuester F; Center for Molecular Medicine Cologne (CMMC), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Schettina P; Center for Molecular Medicine Cologne (CMMC), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Nelles M; Center for Molecular Medicine Cologne (CMMC), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Seeger JM; Institute for Medical Microbiology, Immunology and Hygiene (IMMIH), CECAD Research Center, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.
Kashkar H; Center for Molecular Medicine Cologne (CMMC), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Institute for Medical Microbiology, Immunology and Hygiene (IMMIH), CECAD Research Center, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.
Niemann C; Center for Molecular Medicine Cologne (CMMC), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Centre of Biochemistry, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
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Źródło :
EMBO reports [EMBO Rep] 2021 Oct 05; Vol. 22 (10), pp. e52301. Date of Electronic Publication: 2021 Aug 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis Regulatory Proteins*
Hair Follicle*
Animals ; Apoptosis/genetics ; Mice ; Skin ; Stem Cells
Czasopismo naukowe
Tytuł :
FBXL20 promotes breast cancer malignancy by inhibiting apoptosis through degradation of PUMA and BAX.
Autorzy :
Manne RK; Cancer Biology and Epigenetics Laboratory, National Centre for Cell Science, Pune, Maharashtra, India; Department of Biotechnology, S.P. Pune University, Pune, Maharashtra, India.
Agrawal Y; Cancer Biology and Epigenetics Laboratory, National Centre for Cell Science, Pune, Maharashtra, India; Department of Biotechnology, S.P. Pune University, Pune, Maharashtra, India.
Malonia SK; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Banday S; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Edachery S; Department of Biochemistry, K. S. Hegde Medical Academy, Nitte University, Mangalore, Karnataka, India.
Patel A; Cancer Biology and Epigenetics Laboratory, National Centre for Cell Science, Pune, Maharashtra, India.
Kumar A; Cancer Biology and Epigenetics Laboratory, National Centre for Cell Science, Pune, Maharashtra, India.
Shetty P; Department of Biochemistry, K. S. Hegde Medical Academy, Nitte University, Mangalore, Karnataka, India.
Santra MK; Cancer Biology and Epigenetics Laboratory, National Centre for Cell Science, Pune, Maharashtra, India. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2021 Oct; Vol. 297 (4), pp. 101253. Date of Electronic Publication: 2021 Sep 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*
Proteolysis*
Apoptosis Regulatory Proteins/*metabolism
Breast Neoplasms/*metabolism
F-Box Proteins/*metabolism
Proto-Oncogene Proteins/*metabolism
bcl-2-Associated X Protein/*metabolism
Apoptosis Regulatory Proteins/genetics ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Drug Resistance, Neoplasm/genetics ; F-Box Proteins/genetics ; Female ; HEK293 Cells ; Humans ; MCF-7 Cells ; Proto-Oncogene Proteins/genetics ; bcl-2-Associated X Protein/genetics
Czasopismo naukowe
Tytuł :
Cellular FADD-like IL-1β-converting enzyme-inhibitory protein attenuates myocardial ischemia/reperfusion injury via suppressing apoptosis and autophagy simultaneously.
Autorzy :
Liu D; Institute of Cardiovascular Disease, China Three Gorges University, Yichang, 443003, China; Department of Cardiology, Yichang Central People's Hospital, Yichang, 443003, China; HuBei Clinical Research Center for Ischemic Cardiovascular Disease, Yichang, 443003, China.
Wu H; Institute of Cardiovascular Disease, China Three Gorges University, Yichang, 443003, China; Department of Cardiology, Yichang Central People's Hospital, Yichang, 443003, China; HuBei Clinical Research Center for Ischemic Cardiovascular Disease, Yichang, 443003, China. Electronic address: .
Li YZ; Institute of Cardiovascular Disease, China Three Gorges University, Yichang, 443003, China; Department of Cardiology, Yichang Central People's Hospital, Yichang, 443003, China; HuBei Clinical Research Center for Ischemic Cardiovascular Disease, Yichang, 443003, China.
Yang J; Institute of Cardiovascular Disease, China Three Gorges University, Yichang, 443003, China; Department of Cardiology, Yichang Central People's Hospital, Yichang, 443003, China; HuBei Clinical Research Center for Ischemic Cardiovascular Disease, Yichang, 443003, China.
Yang J; Institute of Cardiovascular Disease, China Three Gorges University, Yichang, 443003, China.
Ding JW; Institute of Cardiovascular Disease, China Three Gorges University, Yichang, 443003, China; Department of Cardiology, Yichang Central People's Hospital, Yichang, 443003, China; HuBei Clinical Research Center for Ischemic Cardiovascular Disease, Yichang, 443003, China.
Zhou G; Institute of Cardiovascular Disease, China Three Gorges University, Yichang, 443003, China; Department of Cardiology, Yichang Central People's Hospital, Yichang, 443003, China; HuBei Clinical Research Center for Ischemic Cardiovascular Disease, Yichang, 443003, China.
Zhang J; Department of Cardiology, Yichang Central People's Hospital, Yichang, 443003, China; HuBei Clinical Research Center for Ischemic Cardiovascular Disease, Yichang, 443003, China; Department of Central Experimental Laboratory, Yichang Central People's Hospital, Yichang, 443003, China.
Wang X; Institute of Cardiovascular Disease, China Three Gorges University, Yichang, 443003, China; Department of Cardiology, Yichang Central People's Hospital, Yichang, 443003, China; HuBei Clinical Research Center for Ischemic Cardiovascular Disease, Yichang, 443003, China.
Fan ZX; Institute of Cardiovascular Disease, China Three Gorges University, Yichang, 443003, China.
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Źródło :
Nutrition, metabolism, and cardiovascular diseases : NMCD [Nutr Metab Cardiovasc Dis] 2021 Jun 07; Vol. 31 (6), pp. 1916-1928. Date of Electronic Publication: 2021 Mar 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*
Autophagy*
CASP8 and FADD-Like Apoptosis Regulating Protein/*metabolism
Myocardial Infarction/*prevention & control
Myocardial Reperfusion Injury/*prevention & control
Myocytes, Cardiac/*metabolism
Animals ; Apoptosis Regulatory Proteins/metabolism ; Autophagy-Related Proteins/metabolism ; CASP8 and FADD-Like Apoptosis Regulating Protein/genetics ; Cells, Cultured ; Disease Models, Animal ; Male ; Myocardial Infarction/metabolism ; Myocardial Infarction/pathology ; Myocardial Reperfusion Injury/genetics ; Myocardial Reperfusion Injury/metabolism ; Myocardial Reperfusion Injury/pathology ; Myocytes, Cardiac/pathology ; NF-kappa B/metabolism ; Rats, Sprague-Dawley ; Signal Transduction ; Up-Regulation
Czasopismo naukowe
Tytuł :
Exercise training and probiotic supplementation effects on skeletal muscle apoptosis prevention in type-Ι diabetic rats.
Autorzy :
Rezaee N; Department of Exercise Physiology, Faculty of Sport Sciences, University of Guilan, Rasht, Iran. Electronic address: .
Rahmani-Nia F; Department of Exercise Physiology, Faculty of Sport Sciences, University of Guilan, Rasht, Iran.
Delfan M; Department of Exercise Physiology, Faculty of Sport Sciences, Alzahra University, Tehran, Iran.
Ghahremani R; Department of Exercise Physiology, Faculty of Sport Sciences, University of Birjand, Birjand, Iran.
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Źródło :
Life sciences [Life Sci] 2021 Nov 15; Vol. 285, pp. 119973. Date of Electronic Publication: 2021 Sep 22.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis*
Physical Conditioning, Animal*
Diabetes Mellitus, Experimental/*therapy
Diabetes Mellitus, Type 1/*therapy
Muscle, Skeletal/*physiopathology
Probiotics/*administration & dosage
Animals ; Apoptosis Regulatory Proteins/metabolism ; Blood Glucose ; Male ; Muscle, Skeletal/metabolism ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Rats ; Rats, Wistar ; Signal Transduction ; Streptozocin
Czasopismo naukowe
Tytuł :
In Vitro Toxicological Assessment of Gadodiamide in Normal Brain SVG P12 Cells.
Autorzy :
Tsai YF; Department of Diagnostic Radiology, Shin-Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan, R.O.C.; School of Medicine, Fu-Jen Catholic University, New Taipei, Taiwan, R.O.C.
Yang JS; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan, R.O.C.
Tsai FJ; School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan, R.O.C.; China Medical University Children's Hospital, China Medical University, Taichung, Taiwan, R.O.C.
Lu CC; Department of Sport Performance, National Taiwan University of Sport, Taichung, Taiwan, R.O.C.
Chiu YJ; Division of Plastic and Reconstructive Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.; .; Department of Surgery, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, R.O.C.; Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, R.O.C.
Tsai SC; Department of Biological Science and Technology, China Medical University, Taichung, Taiwan, R.O.C. .
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Źródło :
In vivo (Athens, Greece) [In Vivo] 2021 Sep-Oct; Vol. 35 (5), pp. 2621-2630.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis Regulatory Proteins*/metabolism
Gadolinium DTPA*/toxicity
Apoptosis ; Brain/metabolism ; Humans
Czasopismo naukowe
Tytuł :
Conditional Knock out of High-Mobility Group Box 1 (HMGB1) in Rods Reduces Autophagy Activation after Retinal Detachment.
Autorzy :
Ross BX; Kellogg Eye Center, Department of Ophthalmology, University of Michigan, 1000 Wall St, Ann Arbor, MI 48105, USA.
Jia L; Kellogg Eye Center, Department of Ophthalmology, University of Michigan, 1000 Wall St, Ann Arbor, MI 48105, USA.
Kong D; Kellogg Eye Center, Department of Ophthalmology, University of Michigan, 1000 Wall St, Ann Arbor, MI 48105, USA.
Wang T; Kellogg Eye Center, Department of Ophthalmology, University of Michigan, 1000 Wall St, Ann Arbor, MI 48105, USA.; Department of Ophthalmology, Xiangya Hospital, Central South University, Changsha 410008, China.
Hager HM; Kellogg Eye Center, Department of Ophthalmology, University of Michigan, 1000 Wall St, Ann Arbor, MI 48105, USA.
Abcouwer SF; Kellogg Eye Center, Department of Ophthalmology, University of Michigan, 1000 Wall St, Ann Arbor, MI 48105, USA.
Zacks DN; Kellogg Eye Center, Department of Ophthalmology, University of Michigan, 1000 Wall St, Ann Arbor, MI 48105, USA.
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Źródło :
Cells [Cells] 2021 Aug 06; Vol. 10 (8). Date of Electronic Publication: 2021 Aug 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Apoptosis*
Autophagy*
HMGB1 Protein/*deficiency
Retinal Detachment/*metabolism
Retinal Rod Photoreceptor Cells/*metabolism
Animals ; Apoptosis Regulatory Proteins/metabolism ; Autophagy-Related Proteins/metabolism ; Cell Survival ; Disease Models, Animal ; Gene Knockdown Techniques ; HMGB1 Protein/genetics ; Inflammation Mediators/metabolism ; Mice, Knockout ; Retinal Detachment/genetics ; Retinal Detachment/pathology ; Retinal Rod Photoreceptor Cells/pathology ; Signal Transduction
Czasopismo naukowe
Tytuł :
Reconstruction of the Fas-Based Death-Inducing Signaling Complex (DISC) Using a Protein-Protein Docking Meta-Approach.
Autorzy :
Mahdizadeh SJ; Department of Chemistry and Molecular Biology, University of Gothenburg, 405 30 Göteborg, Sweden.
Thomas M; Department of Chemistry and Molecular Biology, University of Gothenburg, 405 30 Göteborg, Sweden.
Eriksson LA; Department of Chemistry and Molecular Biology, University of Gothenburg, 405 30 Göteborg, Sweden.
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Źródło :
Journal of chemical information and modeling [J Chem Inf Model] 2021 Jul 26; Vol. 61 (7), pp. 3543-3558. Date of Electronic Publication: 2021 Jul 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*
Signal Transduction*
Death Domain Receptor Signaling Adaptor Proteins/*chemistry
CASP8 and FADD-Like Apoptosis Regulating Protein/chemistry ; Caspase 8 ; Cell Membrane/chemistry ; Fas-Associated Death Domain Protein/chemistry ; Protein Interaction Mapping
Czasopismo naukowe
Tytuł :
Clustering of Death Receptor for Apoptosis Using Nanoscale Patterns of Peptides.
Autorzy :
Wang Y; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-17177 Stockholm, Sweden.
Baars I; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-17177 Stockholm, Sweden.
Fördös F; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-17177 Stockholm, Sweden.
Högberg B; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-17177 Stockholm, Sweden.
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Źródło :
ACS nano [ACS Nano] 2021 Jun 22; Vol. 15 (6), pp. 9614-9626. Date of Electronic Publication: 2021 May 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Receptors, TNF-Related Apoptosis-Inducing Ligand*
TNF-Related Apoptosis-Inducing Ligand*
Apoptosis ; Cluster Analysis ; Humans ; Peptides ; Tumor Necrosis Factor-alpha
Czasopismo naukowe
Tytuł :
A rohitukine derivative IIIM-290 induces p53 dependent mitochondrial apoptosis in acute lymphoblastic leukemia cells.
Autorzy :
Mintoo M; Cancer Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Jammu, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.
Khan S; Cancer Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Jammu, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.
Wani A; Cancer Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Jammu, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.
Malik S; Cancer Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Jammu, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.
Bhurta D; Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Jammu, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.
Bharate S; Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Jammu, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.
Malik F; Cancer Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Jammu, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.
Mondhe D; Cancer Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Jammu, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.
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Źródło :
Molecular carcinogenesis [Mol Carcinog] 2021 Oct; Vol. 60 (10), pp. 671-683. Date of Electronic Publication: 2021 Jul 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents, Phytogenic/*pharmacology
Apoptosis/*drug effects
Chromones/*pharmacology
Mitochondria/*drug effects
Mitochondria/*metabolism
Piperidines/*pharmacology
Precursor Cell Lymphoblastic Leukemia-Lymphoma/*metabolism
Animals ; Apoptosis Regulatory Proteins/genetics ; Apoptosis Regulatory Proteins/metabolism ; Cell Line, Tumor ; Chromones/chemistry ; Disease Models, Animal ; Gene Expression Regulation, Neoplastic ; Humans ; Mice ; Piperidines/chemistry ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Tumor Suppressor Protein p53/metabolism ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Puma, noxa, p53, and p63 differentially mediate stress pathway induced apoptosis.
Autorzy :
Wang J; Department of Pharmacology and Toxicology, University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA.
Thomas HR; Department of Pharmacology and Toxicology, University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA.
Li Z; Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, USA.
Yeo NCF; Department of Pharmacology and Toxicology, University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA.
Scott HE; Department of Biology, University of Alabama at Birmingham Collage of Arts and Sciences Department and Genetics Department, University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA.
Dang N; Department of Pharmacology and Toxicology, University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA.
Hossain MI; Department of Pharmacology and Toxicology, University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA.
Andrabi SA; Department of Pharmacology and Toxicology, University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA.; Department of Neurology, University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA.
Parant JM; Department of Pharmacology and Toxicology, University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA. .
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Źródło :
Cell death & disease [Cell Death Dis] 2021 Jun 30; Vol. 12 (7), pp. 659. Date of Electronic Publication: 2021 Jun 30.
Typ publikacji :
Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*/drug effects
Apoptosis*/radiation effects
DNA Damage*
Endoplasmic Reticulum Stress*/drug effects
Oxidative Stress*/drug effects
Apoptosis Regulatory Proteins/*metabolism
Phosphoproteins/*metabolism
Proto-Oncogene Proteins/*metabolism
Proto-Oncogene Proteins c-bcl-2/*metabolism
Trans-Activators/*metabolism
Tumor Suppressor Protein p53/*metabolism
Zebrafish Proteins/*metabolism
Animals ; Animals, Genetically Modified ; Apoptosis Regulatory Proteins/genetics ; Gene Expression Regulation ; Macrolides/pharmacology ; Phosphoproteins/genetics ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins c-bcl-2/genetics ; Proto-Oncogene Proteins c-mdm2/genetics ; Proto-Oncogene Proteins c-mdm2/metabolism ; Signal Transduction ; Tetradecanoylphorbol Acetate/pharmacology ; Thapsigargin/pharmacology ; Time Factors ; Trans-Activators/genetics ; Transcription, Genetic ; Tumor Suppressor Protein p53/genetics ; X-Rays ; Zebrafish/genetics ; Zebrafish Proteins/genetics
Czasopismo naukowe
Tytuł :
[Effect of DR4 Demethylation to the Proliferation and Apoptosis of Myeloid Leukemia K562 Cells].
Autorzy :
Zhang M; Department of Hematology, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang 471000, Henan Province, China.
Cai LH; Department of Hematology, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang 471000, Henan Province, China.
Yang HP; Department of Hematology, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang 471000, Henan Province, China,E-mail:.
Yang XW; Department of Hematology, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang 471000, Henan Province, China.
Si XH; Xinxiang Medical College, Xinxiang 453003, Henan Province, China.
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Źródło :
Zhongguo shi yan xue ye xue za zhi [Zhongguo Shi Yan Xue Ye Xue Za Zhi] 2021 Apr; Vol. 29 (2), pp. 422-427.
Typ publikacji :
Journal Article
MeSH Terms :
Leukemia, Myeloid*
Receptors, TNF-Related Apoptosis-Inducing Ligand*/metabolism
Apoptosis ; Cell Line, Tumor ; Cell Proliferation ; Demethylation ; Humans ; K562 Cells ; TNF-Related Apoptosis-Inducing Ligand/metabolism
Czasopismo naukowe
Tytuł :
H 2 O 2 mediated FLIP and XIAP down-regulation involves increased ITCH expression and ERK-Akt crosstalk in imatinib resistant Chronic Myeloid Leukemia cell line K562.
Autorzy :
Paul T; Department of Life Sciences, Presidency University, Kolkata, India.
Roy R; Department of Life Sciences, Presidency University, Kolkata, India.
Sarkar RD; Department of Life Sciences, Presidency University, Kolkata, India.
Sinha S; Department of Life Sciences, Presidency University, Kolkata, India.
Biswas N; Department of Life Sciences, Presidency University, Kolkata, India. Electronic address: .
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Źródło :
Free radical biology & medicine [Free Radic Biol Med] 2021 Apr; Vol. 166, pp. 265-276. Date of Electronic Publication: 2021 Feb 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
CASP8 and FADD-Like Apoptosis Regulating Protein*/genetics
Leukemia, Myelogenous, Chronic, BCR-ABL Positive*/drug therapy
Leukemia, Myelogenous, Chronic, BCR-ABL Positive*/genetics
Apoptosis ; Cell Line, Tumor ; Down-Regulation ; Humans ; Hydrogen Peroxide ; Imatinib Mesylate/pharmacology ; K562 Cells ; Proto-Oncogene Proteins c-akt/genetics ; X-Linked Inhibitor of Apoptosis Protein/genetics ; X-Linked Inhibitor of Apoptosis Protein/metabolism
Czasopismo naukowe
Tytuł :
TLR4 deletion increases basal energy expenditure and attenuates heart apoptosis and ER stress but mitigates the training-induced cardiac function and performance improvement.
Autorzy :
de Vicente LG; Postgraduate Program in Rehabilitation and Functional Performance, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil.
Muñoz VR; Laboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences, University of Campinas (UNICAMP), Limeira, São Paulo, Brazil.
Pinto AP; Postgraduate Program in Rehabilitation and Functional Performance, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil.
Rovina RL; School of Physical Education and Sport of Ribeirão Preto, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil.
da Rocha AL; Postgraduate Program in Rehabilitation and Functional Performance, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil.
Marafon BB; School of Physical Education and Sport of Ribeirão Preto, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil.
Tavares MEA; Multicenter Graduate Program in Physiological Sciences, SBFis, São Paulo State University (UNESP), Araçatuba, São Paulo, Brazil.
Teixeira GR; Multicenter Graduate Program in Physiological Sciences, SBFis, São Paulo State University (UNESP), Araçatuba, São Paulo, Brazil; Department of Physical Education, State University of São Paulo (UNESP), Presidente Prudente, São Paulo, Brazil.
Ferrari GD; Department of Biomolecular Sciences, School of Pharmaceutical Sciences of Ribeirao Preto, University of Sao Paulo-FCFRP USP, Ribeirao Preto, Sao Paulo, Brazil.
Alberici LC; Department of Biomolecular Sciences, School of Pharmaceutical Sciences of Ribeirao Preto, University of Sao Paulo-FCFRP USP, Ribeirao Preto, Sao Paulo, Brazil.
Frantz FG; School of Pharmaceutical Sciences of Ribeirão Preto, Department of Clinical, Toxicological, and Bromatological Analysis, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil.
Simabuco FM; Laboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences, University of Campinas (UNICAMP), Limeira, São Paulo, Brazil.
Ropelle ER; Laboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences, University of Campinas (UNICAMP), Limeira, São Paulo, Brazil.
de Moura LP; Laboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences, University of Campinas (UNICAMP), Limeira, São Paulo, Brazil.
Cintra DE; Laboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences, University of Campinas (UNICAMP), Limeira, São Paulo, Brazil.
Pauli JR; Laboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences, University of Campinas (UNICAMP), Limeira, São Paulo, Brazil.
da Silva ASR; Postgraduate Program in Rehabilitation and Functional Performance, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil; School of Physical Education and Sport of Ribeirão Preto, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Nov 15; Vol. 285, pp. 119988. Date of Electronic Publication: 2021 Sep 28.
Typ publikacji :
Journal Article
MeSH Terms :
Heart Ventricles*
Physical Conditioning, Animal*
Ventricular Function*
Apoptosis/*genetics
Endoplasmic Reticulum Stress/*genetics
Energy Metabolism/*genetics
Toll-Like Receptor 4/*genetics
Animals ; Apoptosis Regulatory Proteins/genetics ; Apoptosis Regulatory Proteins/metabolism ; Echocardiography ; Gene Deletion ; Glycogen/metabolism ; Heart Rate ; Inflammation/genetics ; Inflammation/pathology ; Mice ; Mice, Knockout ; RNA, Messenger/metabolism
Czasopismo naukowe
Tytuł :
TRAIL-Armed ER Nanosomes Induce Drastically Enhanced Apoptosis in Resistant Tumor in Combination with the Antagonist of IAPs (AZD5582).
Autorzy :
Hou H; School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 51006, China.
Su K; School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 51006, China.
Huang C; School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 51006, China.
Yuan Q; School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 51006, China.
Li S; School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 51006, China.
Sun J; School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 51006, China.
Lin Y; School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 51006, China.
Du Z; School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 51006, China.
Ke C; YZ Health-tech Inc., Hengqin District, Zhuhai, 519000, China.; School of Pharmacy, Jinan University, Guangzhou, 510632, China.
Yuan Z; School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 51006, China.
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Źródło :
Advanced healthcare materials [Adv Healthc Mater] 2021 Jun; Vol. 10 (11), pp. e2100030. Date of Electronic Publication: 2021 May 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Neoplasms*
TNF-Related Apoptosis-Inducing Ligand*
Alkynes ; Apoptosis ; Cell Line, Tumor ; Endoplasmic Reticulum ; Humans ; Oligopeptides
Czasopismo naukowe
Tytuł :
MicroRNA-200b-3p promotes endothelial cell apoptosis by targeting HDAC4 in atherosclerosis.
Autorzy :
Zhang F; Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Cheng N; Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Du J; Beijing Anzhen Hospital, Capital Medical University, Beijing, China.; Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Beijing, China.; Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, 100029, China.
Zhang H; Beijing Anzhen Hospital, Capital Medical University, Beijing, China. .
Zhang C; Beijing Anzhen Hospital, Capital Medical University, Beijing, China. .; Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Beijing, China. .; Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, 100029, China. .
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Źródło :
BMC cardiovascular disorders [BMC Cardiovasc Disord] 2021 Apr 12; Vol. 21 (1), pp. 172. Date of Electronic Publication: 2021 Apr 12.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*/drug effects
Atherosclerosis/*enzymology
Coronary Artery Disease/*enzymology
Histone Deacetylases/*metabolism
Human Umbilical Vein Endothelial Cells/*enzymology
MicroRNAs/*metabolism
Repressor Proteins/*metabolism
Apoptosis Regulatory Proteins/metabolism ; Atherosclerosis/genetics ; Atherosclerosis/pathology ; Cells, Cultured ; Coronary Artery Disease/genetics ; Coronary Artery Disease/pathology ; Histone Deacetylases/genetics ; Human Umbilical Vein Endothelial Cells/drug effects ; Human Umbilical Vein Endothelial Cells/pathology ; Humans ; Hydrogen Peroxide/toxicity ; Lipoproteins, LDL/toxicity ; MicroRNAs/genetics ; Oxidative Stress ; Repressor Proteins/genetics ; Signal Transduction
Czasopismo naukowe
Tytuł :
Effect of circular-RNA30741 on apoptosis of rat primary cardiomyocytes by regulating MiR-21.
Autorzy :
Pan J; Department of Cardiology, Liaocheng People's Hospital, Liaocheng, China.
Feng Y; Department of Cardiology, Liaocheng Third People's Hospital, Liaocheng, China.
Guo Y; Department of Cardiology, Liaocheng Third People's Hospital, Liaocheng, China.
Kong X; Department of Cardiology, Linqing People's Hospital, Linqing, China - .
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Źródło :
Minerva medica [Minerva Med] 2021 Apr; Vol. 112 (2), pp. 306-308. Date of Electronic Publication: 2019 Jul 17.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis*
MicroRNAs/*metabolism
Myocardial Infarction/*metabolism
Myocytes, Cardiac/*metabolism
RNA, Circular/*metabolism
Adaptor Proteins, Signal Transducing/metabolism ; Animals ; Apoptosis Regulatory Proteins/metabolism ; Cell Survival ; Down-Regulation ; High-Throughput Screening Assays ; Intracellular Signaling Peptides and Proteins/metabolism ; MicroRNAs/blood ; Microarray Analysis/methods ; Myocardial Infarction/blood ; Myocytes, Cardiac/cytology ; Rats ; Smad7 Protein/metabolism ; Up-Regulation
Czasopismo naukowe
Tytuł :
Apoptosis is induced by sub-acute exposure to 3-MCPD and glycidol on Wistar Albino rat brain cells.
Autorzy :
Sevim Ç; Department of Medical Pharmacology, Faculty of Medicine, University of Kastamonu, 37200, Kastamonu, Turkey. Electronic address: .
Özkaraca M; Deparment of Pathology, Faculty of Veterinary, University of Cumhuriyet, 58140, Sivas, Turkey.
Kara M; Deparment of Pharmaceutical Toxicology, Faculty of Pharmacy, University of Istanbul, 34116, Istanbul, Turkey.
Ulaş N; Deparment of Internal Medicine, Faculty of Veterinary, University of Ataturk, 25240, Erzurum, Turkey.
Mendil AS; Deparment of Pathology, Faculty of Veterinary, University of Erciyes, 38280, Kayseri, Turkey.
Margina D; Deparment of Biochemistry, Faculty of Pharmacy, University of Carol Davila, 020956, Bucharest, Romania.
Tsatsakis A; Department of Forensic Sciences and Toxicology, Faculty of Medicine, University of Crete, 71003, Heraklion, Greece.
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Źródło :
Environmental toxicology and pharmacology [Environ Toxicol Pharmacol] 2021 Oct; Vol. 87, pp. 103735. Date of Electronic Publication: 2021 Aug 27.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Brain/*drug effects
Chemosterilants/*toxicity
Epoxy Compounds/*toxicity
Propanols/*toxicity
alpha-Chlorohydrin/*toxicity
Animals ; Apoptosis Inducing Factor/metabolism ; Brain/cytology ; Brain/metabolism ; Caspase 3/metabolism ; Male ; MicroRNAs ; PTEN Phosphohydrolase/genetics ; Proto-Oncogene Proteins c-akt/genetics ; Rats, Wistar
Czasopismo naukowe

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