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Wyszukujesz frazę ""Apoptosis"" wg kryterium: Temat


Tytuł :
Inhibition of Wnt signalling pathway by XAV939 enhances radiosensitivity in human cervical cancer HeLa cells.
Autorzy :
Zhang J; Department of Radiation Medicine, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China.; Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Lanzhou, China.; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.
Si J; Department of Radiation Medicine, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China.; Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Lanzhou, China.; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.
Gan L; Department of Radiation Medicine, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China.; Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Lanzhou, China.; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.
Guo M; School of Pharmacy, Lanzhou University, Lanzhou, China.
Yan J; Department of Radiation Medicine, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China.; Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Lanzhou, China.; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.
Chen Y; Department of Radiation Medicine, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China.; Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Lanzhou, China.; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.
Wang F; Department of Radiation Medicine, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China.; Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Lanzhou, China.; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.
Xie Y; Department of Radiation Medicine, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China.; Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Lanzhou, China.; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.
Wang Y; Department of Radiation Medicine, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China.; Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Lanzhou, China.; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.
Zhang H; Department of Radiation Medicine, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China.; Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Lanzhou, China.; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.
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Źródło :
Artificial cells, nanomedicine, and biotechnology [Artif Cells Nanomed Biotechnol] 2020 Dec; Vol. 48 (1), pp. 479-487.
Typ publikacji :
Journal Article; Video-Audio Media
MeSH Terms :
Apoptosis*/drug effects
Apoptosis*/radiation effects
Radiation Tolerance*/drug effects
Radiation Tolerance*/radiation effects
Uterine Cervical Neoplasms*/metabolism
Uterine Cervical Neoplasms*/pathology
Uterine Cervical Neoplasms*/radiotherapy
Wnt Signaling Pathway*/drug effects
Wnt Signaling Pathway*/radiation effects
Heterocyclic Compounds, 3-Ring/*pharmacology
Apoptosis Regulatory Proteins/metabolism ; Female ; G2 Phase Cell Cycle Checkpoints/drug effects ; G2 Phase Cell Cycle Checkpoints/radiation effects ; HeLa Cells ; Humans ; M Phase Cell Cycle Checkpoints/drug effects ; M Phase Cell Cycle Checkpoints/radiation effects ; Neoplasm Proteins/metabolism
Czasopismo naukowe
Tytuł :
Anti‑survival and pro‑apoptotic effects of meridianin C derivatives on MV4‑11 human acute myeloid leukemia cells.
Autorzy :
Cho H; Department of Molecular Medicine, College of Medicine, Keimyung University, Daegu 42601, Republic of Korea.
Yadav AK; Department of Molecular Medicine, College of Medicine, Keimyung University, Daegu 42601, Republic of Korea.
Do Y; Department of Hematology and Oncology, College of Medicine, Keimyung University, Daegu 42601, Republic of Korea.
Heo M; Department of Hematology and Oncology, College of Medicine, Keimyung University, Daegu 42601, Republic of Korea.
Bishop-Bailey D; Comparative Biomedical Sciences, Royal Veterinary College, London NW 10TU, United Kingdom.
Lee J; Department of Chemistry, College of Life Science, Keimyung University, Daegu 42601, Republic of Korea.
Jang BC; Department of Molecular Medicine, College of Medicine, Keimyung University, Daegu 42601, Republic of Korea.
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Źródło :
International journal of oncology [Int J Oncol] 2020 Jan; Vol. 56 (1), pp. 368-378. Date of Electronic Publication: 2019 Nov 27.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis*
Cell Proliferation*
Apoptosis Regulatory Proteins/*metabolism
Indoles/*chemistry
Indoles/*pharmacology
Leukemia, Myeloid, Acute/*drug therapy
Protein Kinase Inhibitors/*pharmacology
Proto-Oncogene Proteins c-pim-1/*antagonists & inhibitors
Pyrimidines/*chemistry
Pyrimidines/*pharmacology
Apoptosis Regulatory Proteins/genetics ; Caspase 9/genetics ; Caspase 9/metabolism ; Humans ; Leukemia, Myeloid, Acute/metabolism ; Leukemia, Myeloid, Acute/pathology ; Phosphorylation ; Protein Kinase Inhibitors/chemistry ; Tumor Cells, Cultured ; X-Linked Inhibitor of Apoptosis Protein/genetics ; X-Linked Inhibitor of Apoptosis Protein/metabolism
Czasopismo naukowe
Tytuł :
Increased Ephrin-B2 expression in pericytes contributes to retinal vascular death in rodents.
Autorzy :
Coucha M; Department of Pharmaceutical Sciences, School of Pharmacy, South University, Savannah, GA, USA.
Barrett AC; Department of Biomedical Sciences, School of Medicine, Mercer University, Savannah, GA, USA.
Bailey J; Department of Biomedical Sciences, School of Medicine, Mercer University, Savannah, GA, USA.
Abdelghani M; Department of Biomedical Sciences, School of Medicine, Mercer University, Savannah, GA, USA.
Abdelsaid M; Department of Biomedical Sciences, School of Medicine, Mercer University, Savannah, GA, USA. Electronic address: .
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Źródło :
Vascular pharmacology [Vascul Pharmacol] 2020 Aug; Vol. 131, pp. 106761. Date of Electronic Publication: 2020 Jun 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*
Diabetic Retinopathy/*metabolism
Ephrin-B2/*metabolism
Pericytes/*metabolism
Retinal Neovascularization/*metabolism
Retinal Vessels/*metabolism
Animals ; Apoptosis Regulatory Proteins/metabolism ; Diabetes Mellitus, Experimental/chemically induced ; Diabetes Mellitus, Experimental/complications ; Diabetic Retinopathy/etiology ; Diabetic Retinopathy/genetics ; Diabetic Retinopathy/pathology ; Ephrin-B2/deficiency ; Ephrin-B2/genetics ; Humans ; Inflammation Mediators/metabolism ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Pericytes/pathology ; Rats, Wistar ; Retinal Neovascularization/etiology ; Retinal Neovascularization/genetics ; Retinal Neovascularization/pathology ; Retinal Vessels/pathology ; Signal Transduction ; Streptozocin
Czasopismo naukowe
Tytuł :
Effects of p38 MAPK signaling pathway on cognitive function and recovery of neuronal function after hypoxic-ischemic brain injury in newborn rats.
Autorzy :
Zhu Z; Departments of Rehabilitation Medicine, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China.
Ge M; Departments of Hand Surgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China.
Li C; Departments of Rehabilitation Medicine, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China.
Yu L; Department of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China.
Gu Y; Department of Neurosurgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China. Electronic address: .
Hu Y; Departments of Rehabilitation Medicine, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China. Electronic address: .
Cao Z; Department of Intensive Care Unit, Nantong Third People's Hospital, Nantong, Jiangsu Province, China. Electronic address: .
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Źródło :
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia [J Clin Neurosci] 2020 Aug; Vol. 78, pp. 365-370. Date of Electronic Publication: 2020 Apr 30.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis*/drug effects
Recovery of Function*
Cognition/*drug effects
Hypoxia-Ischemia, Brain/*physiopathology
Neurons/*physiology
p38 Mitogen-Activated Protein Kinases/*pharmacology
Animals ; Animals, Newborn ; Apoptosis Regulatory Proteins/drug effects ; Hippocampus/metabolism ; Learning/drug effects ; Male ; Memory/drug effects ; Neurons/drug effects ; Rats ; p38 Mitogen-Activated Protein Kinases/metabolism
Czasopismo naukowe
Tytuł :
[Antitumor Activity of TRAIL-Mu3 Protein in vitro and in vivo and the Mechanisms].
Autorzy :
Yang T; Cancer Research Institute, Chengdu University of Traditional Chinese Medicine, Chengdu 610037, China.
Zhu AJ; Department of Emergency, West China Hospital, Sichuan University, Chengdu 610041, China.
Wang JS; Department of Gynaecology and Obstetrics, North Sichuan Medical College, Nanchong 637100, China.
Jin Z; School of Basic Medical Science, Chengdu University of Traditional Chinese Medicine, Chengdu 610037, China.
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Źródło :
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition [Sichuan Da Xue Xue Bao Yi Xue Ban] 2020 May; Vol. 51 (3), pp. 304-311.
Typ publikacji :
Journal Article
MeSH Terms :
Lung Neoplasms*/drug therapy
Lung Neoplasms*/genetics
Receptors, TNF-Related Apoptosis-Inducing Ligand*/genetics
TNF-Related Apoptosis-Inducing Ligand*/genetics
Animals ; Apoptosis ; Cell Line, Tumor ; Humans ; Mice
Czasopismo naukowe
Tytuł :
ER Stress Leaves an Inflammatory TRAIL.
Autorzy :
Roca Portoles A; Institute of Cancer Sciences, Cancer Research UK Beatson Institute, University of Glasgow, Switchback Road, Glasgow G61 1BD, UK.
Tait SWG; Institute of Cancer Sciences, Cancer Research UK Beatson Institute, University of Glasgow, Switchback Road, Glasgow G61 1BD, UK. Electronic address: .
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Źródło :
Developmental cell [Dev Cell] 2020 Mar 23; Vol. 52 (6), pp. 678-680.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Receptors, TNF-Related Apoptosis-Inducing Ligand*
TNF-Related Apoptosis-Inducing Ligand*
Apoptosis ; Endoplasmic Reticulum Stress ; Humans ; Inflammation ; Plant Leaves
Czasopismo naukowe
Tytuł :
Xanthatin mediates G 2 /M cell cycle arrest, autophagy and apoptosis via ROS/XIAP signaling in human colon cancer cells.
Autorzy :
Geng YD; Department of Pharmacy, Anhui Provincial Hospital, Anhui Medical University, Hefei, Anhui, China.
Zhang L; Department of Pharmacy, Anhui Provincial Hospital, Anhui Medical University, Hefei, Anhui, China.
Wang GY; Department of Pharmacy, Anhui Provincial Hospital, Anhui Medical University, Hefei, Anhui, China.
Feng XJ; Department of Pharmacy, Anhui Provincial Hospital, Anhui Medical University, Hefei, Anhui, China.
Chen ZL; Department of Pharmacy, Anhui Provincial Hospital, Anhui Medical University, Hefei, Anhui, China.
Jiang L; Department of Pharmacy, Anhui Provincial Hospital, Anhui Medical University, Hefei, Anhui, China.
Shen AZ; Department of Pharmacy, Anhui Provincial Hospital, Anhui Medical University, Hefei, Anhui, China.
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Źródło :
Natural product research [Nat Prod Res] 2020 Sep; Vol. 34 (18), pp. 2616-2620. Date of Electronic Publication: 2018 Dec 27.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Autophagy/*drug effects
Cell Cycle Checkpoints/*drug effects
Colonic Neoplasms/*drug therapy
Furans/*therapeutic use
Signal Transduction/*drug effects
Antineoplastic Agents, Phytogenic/isolation & purification ; Antineoplastic Agents, Phytogenic/pharmacology ; Asteraceae/chemistry ; Cell Line, Tumor ; Colonic Neoplasms/metabolism ; Colonic Neoplasms/pathology ; Furans/isolation & purification ; Furans/pharmacology ; G2 Phase Cell Cycle Checkpoints ; Humans ; Reactive Oxygen Species/metabolism ; X-Linked Inhibitor of Apoptosis Protein/metabolism ; Xanthium/chemistry
Czasopismo naukowe
Tytuł :
MiR-29a in mesenchymal stem cells inhibits FSTL1 secretion and promotes cardiac myocyte apoptosis in hypoxia-reoxygenation injury.
Autorzy :
Li KS; Department of Cardiothoracic Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, No. 321 Zhongshan Road, Nanjing 210008, Jiangsu Province, PR China.
Jiang WP; Department of Cardiology, Shenzhen University General Hospital, Shenzhen 518000, Guangdong Province, PR China.
Li QC; Puyang Medical College, Shangyang Road and Wenyan Street, Puyang 457000, Henan Province, PR China.
Zhang HW; Second Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu Province, PR China.
Bai Y; Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Road, Wuhan 430030, Hubei Province, PR China.
Zhang X; Department of Geratology, The First Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou 310003, Zhejiang Province, PR China.
Li HY; Department of Cardiology, Shenzhen University General Hospital, Shenzhen 518000, Guangdong Province, PR China. Electronic address: .
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Źródło :
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology [Cardiovasc Pathol] 2020 May - Jun; Vol. 46, pp. 107180. Date of Electronic Publication: 2019 Nov 19.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis*
Follistatin-Related Proteins/*metabolism
Mesenchymal Stem Cells/*metabolism
MicroRNAs/*metabolism
Myocardial Reperfusion Injury/*metabolism
Myocytes, Cardiac/*metabolism
Animals ; Apoptosis Regulatory Proteins/genetics ; Apoptosis Regulatory Proteins/metabolism ; Cell Hypoxia ; Cell Line ; Follistatin-Related Proteins/genetics ; Janus Kinase 2/metabolism ; Mesenchymal Stem Cells/pathology ; MicroRNAs/genetics ; Myocardial Reperfusion Injury/genetics ; Myocardial Reperfusion Injury/pathology ; Myocytes, Cardiac/pathology ; Rats ; STAT3 Transcription Factor/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
The selective BDNF overexpression in neurons protects neuroglial networks against OGD and glutamate-induced excitotoxicity.
Autorzy :
Gaidin SG; Institute of Cell Biophysics, Federal Research Center 'Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences', Russian Academy of Sciences, Pushchino, Russia.
Turovskaya MV; Institute of Cell Biophysics, Federal Research Center 'Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences', Russian Academy of Sciences, Pushchino, Russia.
Gavrish MS; Institute of Biology and Biomedicine, Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, Russia.
Babaev AA; Institute of Biology and Biomedicine, Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, Russia.
Mal'tseva VN; Institute of Cell Biophysics, Federal Research Center 'Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences', Russian Academy of Sciences, Pushchino, Russia.
Blinova EV; I.M. Sechenov First Moscow State Medical University, Moscow, Russia.; N. P. Ogarev Mordovia State University, Saransk, Russia.
Turovsky EA; Institute of Cell Biophysics, Federal Research Center 'Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences', Russian Academy of Sciences, Pushchino, Russia.
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Źródło :
The International journal of neuroscience [Int J Neurosci] 2020 Apr; Vol. 130 (4), pp. 363-383. Date of Electronic Publication: 2019 Nov 26.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis*
Astrocytes/*metabolism
Brain Ischemia/*metabolism
Brain-Derived Neurotrophic Factor/*metabolism
Hippocampus/*metabolism
Neurons/*metabolism
Animals ; Apoptosis Regulatory Proteins/metabolism ; Brain Ischemia/chemically induced ; Calcium/metabolism ; Cells, Cultured ; Glutamic Acid/administration & dosage ; Rats, Sprague-Dawley ; Receptors, AMPA/metabolism ; Receptors, N-Methyl-D-Aspartate/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
Licochalcone H Synthesized by Modifying Structure of Licochalcone C Extracted from Glycyrrhiza inflata Induces Apoptosis of Esophageal Squamous Cell Carcinoma Cells.
Autorzy :
Kwak AW; Department of Pharmacy, College of Pharmacy, Mokpo National University, Jeonnam, 58554, Republic of Korea.
Cho SS; Department of Pharmacy, College of Pharmacy, Mokpo National University, Jeonnam, 58554, Republic of Korea.
Yoon G; Department of Pharmacy, College of Pharmacy, Mokpo National University, Jeonnam, 58554, Republic of Korea.
Oh HN; Department of Pharmacy, College of Pharmacy, Mokpo National University, Jeonnam, 58554, Republic of Korea.
Lee MH; Basic Medical College, Zhengzhou University, Zhengzhou, 450001, Henan, China.; The China-US (Henan) Hormel Cancer Institute, Zhengzhou, 450008, Henan, PR China.
Chae JI; Department of Dental Pharmacology, School of Dentistry, BK21 Plus, Chonbuk National University, Jeonju, 54896, Republic of Korea.
Shim JH; Department of Pharmacy, College of Pharmacy, Mokpo National University, Jeonnam, 58554, Republic of Korea. .; The China-US (Henan) Hormel Cancer Institute, Zhengzhou, 450008, Henan, PR China. .
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Źródło :
Cell biochemistry and biophysics [Cell Biochem Biophys] 2020 Mar; Vol. 78 (1), pp. 65-76. Date of Electronic Publication: 2019 Nov 09.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis*/drug effects
Chalcones/*chemistry
Glycyrrhiza/*chemistry
Apoptosis Regulatory Proteins/metabolism ; Cell Line, Tumor ; Chalcones/chemical synthesis ; Chalcones/isolation & purification ; Chalcones/pharmacology ; Endoplasmic Reticulum Stress/drug effects ; Esophageal Neoplasms/metabolism ; Esophageal Neoplasms/pathology ; Esophageal Squamous Cell Carcinoma/metabolism ; Esophageal Squamous Cell Carcinoma/pathology ; G2 Phase Cell Cycle Checkpoints/drug effects ; Glycyrrhiza/metabolism ; Humans ; Janus Kinases/metabolism ; Membrane Potential, Mitochondrial/drug effects ; Reactive Oxygen Species/chemistry ; Reactive Oxygen Species/metabolism ; Signal Transduction/drug effects ; p38 Mitogen-Activated Protein Kinases/metabolism
Czasopismo naukowe
Tytuł :
Targeted invalidation of SR-B1 in macrophages reduces macrophage apoptosis and accelerates atherosclerosis.
Autorzy :
Galle-Treger L; Sorbonne Université, INSERM, UMR_S 1166 ICAN, F-75013, Paris, France.
Moreau M; Sorbonne Université, INSERM, UMR_S 1166 ICAN, F-75013, Paris, France.
Ballaire R; Sorbonne Université, INSERM, UMR_S 1166 ICAN, F-75013, Paris, France.
Poupel L; Sorbonne Université, INSERM, UMR_S 1166 ICAN, F-75013, Paris, France.
Huby T; Sorbonne Université, INSERM, UMR_S 1166 ICAN, F-75013, Paris, France.
Sasso E; Ceinge Biotecnologie Avanzate S.C.R.L, Via Gaetano Salvatore 486, 80145, Napoli, Italy.; Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università di Napoli Federico II, 80131, Napoli, Italy.
Troise F; Ceinge Biotecnologie Avanzate S.C.R.L, Via Gaetano Salvatore 486, 80145, Napoli, Italy.
Poti F; Department of Medicine and Surgery, Unit of Neurosciences, University of Parma, Parma, Italy.
Lesnik P; Sorbonne Université, INSERM, UMR_S 1166 ICAN, F-75013, Paris, France.
Le Goff W; Sorbonne Université, INSERM, UMR_S 1166 ICAN, F-75013, Paris, France.
Gautier EL; Sorbonne Université, INSERM, UMR_S 1166 ICAN, F-75013, Paris, France.
Huby T; Sorbonne Université, INSERM, UMR_S 1166 ICAN, F-75013, Paris, France.
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Źródło :
Cardiovascular research [Cardiovasc Res] 2020 Mar 01; Vol. 116 (3), pp. 554-565.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*
Plaque, Atherosclerotic*
Aorta/*metabolism
Aortic Diseases/*metabolism
Atherosclerosis/*metabolism
Macrophages/*metabolism
Scavenger Receptors, Class B/*deficiency
Animals ; Aorta/pathology ; Aortic Diseases/genetics ; Aortic Diseases/pathology ; Apoptosis Regulatory Proteins/metabolism ; Atherosclerosis/genetics ; Atherosclerosis/pathology ; Bone Marrow Transplantation ; Cholesterol/metabolism ; Disease Models, Animal ; Disease Progression ; Humans ; Macrophages/pathology ; Macrophages/transplantation ; Mice, Inbred C57BL ; Mice, Knockout ; Receptors, LDL/deficiency ; Receptors, LDL/genetics ; Receptors, Scavenger/metabolism ; STAT3 Transcription Factor/metabolism ; Scavenger Receptors, Class B/genetics ; Signal Transduction ; THP-1 Cells
Czasopismo naukowe
Tytuł :
Activation of Piezo1 sensitizes cells to TRAIL-mediated apoptosis through mitochondrial outer membrane permeability.
Autorzy :
Hope JM; Department of Biomedical Engineering, Vanderbilt University, 5824 Stevenson Center, Nashville, TN, 37235, USA.
Lopez-Cavestany M; Department of Biomedical Engineering, Vanderbilt University, 5824 Stevenson Center, Nashville, TN, 37235, USA.
Wang W; Department of Biomedical Engineering, Vanderbilt University, 5824 Stevenson Center, Nashville, TN, 37235, USA.
Reinhart-King CA; Department of Biomedical Engineering, Vanderbilt University, 5824 Stevenson Center, Nashville, TN, 37235, USA.
King MR; Department of Biomedical Engineering, Vanderbilt University, 5824 Stevenson Center, Nashville, TN, 37235, USA. .
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Źródło :
Cell death & disease [Cell Death Dis] 2019 Nov 04; Vol. 10 (11), pp. 837. Date of Electronic Publication: 2019 Nov 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Apoptosis*
Models, Biological*
Ion Channels/*metabolism
Mitochondrial Membranes/*metabolism
Neoplasms/*metabolism
TNF-Related Apoptosis-Inducing Ligand/*pharmacology
Humans ; Intercellular Signaling Peptides and Proteins/pharmacology ; Ion Channels/antagonists & inhibitors ; Ion Channels/genetics ; Neoplasms/drug therapy ; Neoplasms/pathology ; PC-3 Cells ; Permeability ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Pyrazines/pharmacology ; Spider Venoms/pharmacology ; Thiadiazoles/pharmacology ; X-Linked Inhibitor of Apoptosis Protein/metabolism ; bcl-2-Associated X Protein/metabolism
Czasopismo naukowe
Tytuł :
[ In vivo Study of siRNA Silencing XIAP Gene to Reverse Taxol-resistance in Human Ovarian Cancer Cells].
Autorzy :
Li RH; Department of Obstetrics and Gynecology, Henan Provincial People's Hospital, Zhengzhou 450003, China.; Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu 610041, China.; Key Laboratory of Obstetric and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education (Sichuan University), Chengdu 610041, China.
Yue C; Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu 610041, China.; Key Laboratory of Obstetric and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education (Sichuan University), Chengdu 610041, China.
Wei BB; Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu 610041, China.; Key Laboratory of Obstetric and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education (Sichuan University), Chengdu 610041, China.
Liu J; Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu 610041, China.; Key Laboratory of Obstetric and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education (Sichuan University), Chengdu 610041, China.
Liu H; Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu 610041, China.; Key Laboratory of Obstetric and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education (Sichuan University), Chengdu 610041, China.
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Źródło :
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition [Sichuan Da Xue Xue Bao Yi Xue Ban] 2020 May; Vol. 51 (3), pp. 320-324.
Typ publikacji :
Journal Article
MeSH Terms :
Ovarian Neoplasms*/drug therapy
Ovarian Neoplasms*/genetics
X-Linked Inhibitor of Apoptosis Protein*/genetics
Animals ; Antineoplastic Agents, Phytogenic/pharmacology ; Apoptosis ; Cell Line, Tumor ; Cell Proliferation ; Drug Resistance, Neoplasm/genetics ; Female ; Humans ; Mice ; Mice, Nude ; Paclitaxel/pharmacology ; RNA, Small Interfering/genetics
Czasopismo naukowe
Tytuł :
CBL0137 administration suppresses human hepatocellular carcinoma cells proliferation and induces apoptosis associated with multiple cell death related proteins.
Autorzy :
Albahde MAH; Department of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.; Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province, School of Medicine, Zhejiang University, Hangzhou, China.; Clinical Research Center of Hepatobiliary and Pancreatic Diseases of Zhejiang Province, School of Medicine, Zhejiang University, Hangzhou, China.
Zhang P; Department of Anesthesiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Chen H; Department of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.; Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province, School of Medicine, Zhejiang University, Hangzhou, China.
Wang W; Department of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.; Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province, School of Medicine, Zhejiang University, Hangzhou, China.; Clinical Research Center of Hepatobiliary and Pancreatic Diseases of Zhejiang Province, School of Medicine, Zhejiang University, Hangzhou, China.; Clinical Medicine Innovation Center of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Disease, Zhejiang University, Hangzhou, China.
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Źródło :
Neoplasma [Neoplasma] 2020 May; Vol. 67 (3), pp. 547-556. Date of Electronic Publication: 2020 Mar 24.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis*
Carbazoles/*pharmacology
Carcinoma, Hepatocellular/*pathology
Liver Neoplasms/*pathology
Apoptosis Regulatory Proteins/genetics ; Carcinoma, Hepatocellular/drug therapy ; Cell Line, Tumor ; Cell Proliferation ; Humans ; Liver Neoplasms/drug therapy ; Proto-Oncogene Proteins/genetics ; Tumor Suppressor Protein p53/genetics ; bcl-2-Associated X Protein/genetics
Czasopismo naukowe
Tytuł :
Toxicopathological studies on the effects of T-2 mycotoxin and their interaction in juvenile goats.
Autorzy :
Nayakwadi S; Central Institute for Research on Goats (CIRG), Makhdoom, Mathura, India.; Animal Science Section, ICAR-Central Coastal Agricultural Research Institute, Ela, Goa, India.
Ramu R; Division of Biotechnology and Bioinformatics, Department of Water & Health Sciences-Faculty of Life Sciences, JSS Academy of Higher Education and Research (Deemed to be University), Mysuru, India.
Kumar Sharma A; Central Institute for Research on Goats (CIRG), Makhdoom, Mathura, India.; Division of Pathology, Mycotic and Mycotoxic Diseases Laboratory, Indian Veterinary Research Institute, Izatnagar, India.
Kumar Gupta V; CADRAD, ICAR-Indian Veterinary Research Institute, Izatnagar, India.
Rajukumar K; ICAR-National Institute of High Security Animal Diseases, Bhopal, India.
Kumar V; Central Institute for Research on Goats (CIRG), Makhdoom, Mathura, India.
Shirahatti PS; Department of Biotechnology, Teresian College, Siddhartha Nagara, Mysuru, India.
L R; Karnataka Veterinary Animal Fisheries University, Bidar, Karnataka, India.
Basalingappa KM; Division of Molecular Biology, Department of Water & Health Sciences-Faculty of Life Sciences, JSS Academy of Higher Education and Research (Deemed to be University), Mysuru, India.
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Źródło :
PloS one [PLoS One] 2020 Mar 26; Vol. 15 (3), pp. e0229463. Date of Electronic Publication: 2020 Mar 26 (Print Publication: 2020).
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis*
Gene Expression Regulation/*drug effects
Goats/*physiology
Inflammation Mediators/*metabolism
Liver/*pathology
Oxidative Stress/*drug effects
T-2 Toxin/*toxicity
Animals ; Apoptosis Regulatory Proteins/metabolism ; Brain/drug effects ; Brain/metabolism ; Brain/pathology ; Cytokines/metabolism ; Heat-Shock Proteins/metabolism ; Intestine, Small/drug effects ; Intestine, Small/metabolism ; Intestine, Small/pathology ; Kidney/drug effects ; Kidney/metabolism ; Kidney/pathology ; Liver/drug effects ; Liver/metabolism ; Lymph Nodes/drug effects ; Lymph Nodes/metabolism ; Lymph Nodes/pathology ; Spleen/drug effects ; Spleen/metabolism ; Spleen/pathology
Czasopismo naukowe
Tytuł :
Hyperforin induces apoptosis through extrinsic/intrinsic pathways and inhibits EGFR/ERK/NF-κB-mediated anti-apoptotic potential in glioblastoma.
Autorzy :
Hsu FT; Department of Biological Science and Technology, China Medical University, Taichung, Taiwan.
Chen WT; Department of Psychiatry, Zuoying Branch of Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan.
Wu CT; Department of Radiation Oncology, Show Chwan Memorial Hospital, Changhua, Taiwan.
Chung JG; Department of Biological Science and Technology, China Medical University, Taichung, Taiwan.; Department of Biotechnology, Asia University, Taichung, Taiwan.
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Źródło :
Environmental toxicology [Environ Toxicol] 2020 Oct; Vol. 35 (10), pp. 1058-1069. Date of Electronic Publication: 2020 Jun 02.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents, Phytogenic/*pharmacology
Apoptosis/*drug effects
Extracellular Signal-Regulated MAP Kinases/*metabolism
Phloroglucinol/*analogs & derivatives
Terpenes/*pharmacology
Transcription Factor RelA/*metabolism
Antineoplastic Agents, Phytogenic/isolation & purification ; Apoptosis Regulatory Proteins/metabolism ; Brain Neoplasms/metabolism ; Brain Neoplasms/pathology ; Cell Line, Tumor ; Cell Survival/drug effects ; ErbB Receptors/metabolism ; Glioblastoma/metabolism ; Glioblastoma/pathology ; Humans ; Hypericum/chemistry ; Phloroglucinol/isolation & purification ; Phloroglucinol/pharmacology ; Signal Transduction ; Terpenes/isolation & purification ; Transcription Factor RelA/genetics
Czasopismo naukowe
Tytuł :
Mesenchymal Stem Cells Combined With IFNγ Induce Apoptosis of Breast Cancer Cells Partially Through TRAIL.
Autorzy :
Yenilmez EN; Department of Molecular Medicine, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey.
Genc D; Muğla Sıtkı Koçman University, Health Sciences Faculty, Muğla, Turkey.
Farooqi AA; Institute of Biomedical and Genetic Engineering (IBGE), Islamabad, Pakistan.
Tunoglu S; Department of Molecular Medicine, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey.
Zeybek U; Department of Molecular Medicine, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey.
Akkoc T; Division of Pediatric Allergy-Immunology, Faculty of Medicine, Marmara University, Istanbul, Turkey .
Yaylim İ; Department of Molecular Medicine, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey.
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Źródło :
Anticancer research [Anticancer Res] 2020 Oct; Vol. 40 (10), pp. 5641-5647.
Typ publikacji :
Journal Article
MeSH Terms :
Breast Neoplasms/*drug therapy
Interferon-gamma/*pharmacology
Mesenchymal Stem Cells/*metabolism
TNF-Related Apoptosis-Inducing Ligand/*genetics
Apoptosis/drug effects ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Coculture Techniques ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Interferon-gamma/genetics ; MCF-7 Cells ; Mesenchymal Stem Cells/cytology
Czasopismo naukowe
Tytuł :
DR5 related autophagy can promote apoptosis in gliomas after irradiation.
Autorzy :
Zhang P; School of Life Science, Beijing Institute of Technology, Beijing, 100081, China.
Wang H; School of Life Science, Beijing Institute of Technology, Beijing, 100081, China.
Chen Y; School of Life Science, Beijing Institute of Technology, Beijing, 100081, China.
Lodhi AF; School of Life Science, Beijing Institute of Technology, Beijing, 100081, China; Department of Microbiology, Faculty of Health Sciences, Hazara University, Mansehra, Pakistan.
Sun C; School of Life Science, Beijing Institute of Technology, Beijing, 100081, China.
Sun F; School of Life Science, Beijing Institute of Technology, Beijing, 100081, China.
Yan L; School of Life Science, Beijing Institute of Technology, Beijing, 100081, China.
Deng Y; School of Life Science, Beijing Institute of Technology, Beijing, 100081, China.
Ma H; School of Life Science, Beijing Institute of Technology, Beijing, 100081, China. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2020 Feb 19; Vol. 522 (4), pp. 910-916. Date of Electronic Publication: 2019 Dec 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*/genetics
Apoptosis*/radiation effects
Autophagy*/genetics
Autophagy*/radiation effects
Brain Neoplasms/*pathology
Brain Neoplasms/*radiotherapy
Glioma/*pathology
Glioma/*radiotherapy
Receptors, TNF-Related Apoptosis-Inducing Ligand/*metabolism
Brain Neoplasms/genetics ; Caspase 8/metabolism ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic ; Glioma/genetics ; Histones/metabolism ; Humans ; Methylation ; Receptors, TNF-Related Apoptosis-Inducing Ligand/genetics ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
The pseudo-caspase FLIP(L) regulates cell fate following p53 activation.
Autorzy :
Lees A; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, Northern Ireland BT9 7BL, United Kingdom.
McIntyre AJ; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, Northern Ireland BT9 7BL, United Kingdom.
Crawford NT; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, Northern Ireland BT9 7BL, United Kingdom.
Falcone F; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, Northern Ireland BT9 7BL, United Kingdom.
McCann C; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, Northern Ireland BT9 7BL, United Kingdom.
Holohan C; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, Northern Ireland BT9 7BL, United Kingdom.
Quinn GP; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, Northern Ireland BT9 7BL, United Kingdom.
Roberts JZ; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, Northern Ireland BT9 7BL, United Kingdom.
Sessler T; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, Northern Ireland BT9 7BL, United Kingdom.
Gallagher PF; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, Northern Ireland BT9 7BL, United Kingdom.
Gregg GMA; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, Northern Ireland BT9 7BL, United Kingdom.
McAllister K; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, Northern Ireland BT9 7BL, United Kingdom.
McLaughlin KM; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, Northern Ireland BT9 7BL, United Kingdom.
Allen WL; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, Northern Ireland BT9 7BL, United Kingdom.
Egan LJ; Discipline of Pharmacology & Therapeutics, Lambe Institute for Translational Research, School of Medicine, College of Medicine, Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.
Ryan AE; Discipline of Pharmacology & Therapeutics, Lambe Institute for Translational Research, School of Medicine, College of Medicine, Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.; Regenerative Medicine Institute, College of Medicine, Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.
Labonte-Wilson MJ; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, Northern Ireland BT9 7BL, United Kingdom.
Dunne PD; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, Northern Ireland BT9 7BL, United Kingdom.
Wappett M; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, Northern Ireland BT9 7BL, United Kingdom.
Coyle VM; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, Northern Ireland BT9 7BL, United Kingdom.
Johnston PG; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, Northern Ireland BT9 7BL, United Kingdom.
Kerr EM; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, Northern Ireland BT9 7BL, United Kingdom.
Longley DB; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, Northern Ireland BT9 7BL, United Kingdom; .
McDade SS; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, Northern Ireland BT9 7BL, United Kingdom; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Jul 28; Vol. 117 (30), pp. 17808-17819. Date of Electronic Publication: 2020 Jul 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
CASP8 and FADD-Like Apoptosis Regulating Protein/*metabolism
Tumor Suppressor Protein p53/*metabolism
Acetylation ; Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Apoptosis/genetics ; Benzamides/pharmacology ; Caspase 8/metabolism ; Cell Cycle/drug effects ; Cell Cycle/genetics ; Cell Line, Tumor ; Drug Synergism ; Gene Expression Regulation ; Humans ; Imidazoles/metabolism ; Models, Biological ; Piperazines/metabolism ; Protein Binding ; Protein Kinase Inhibitors/pharmacology ; Proto-Oncogene Proteins c-mdm2/metabolism ; Pyridines/pharmacology ; Receptors, TNF-Related Apoptosis-Inducing Ligand/metabolism ; TNF-Related Apoptosis-Inducing Ligand/metabolism ; Tumor Suppressor Protein p53/genetics
Czasopismo naukowe
Tytuł :
Plumbagin protects the myocardial damage by modulating the cardiac biomarkers, antioxidants, and apoptosis signaling in the doxorubicin-induced cardiotoxicity in rats.
Autorzy :
Li Z; Department of Cardiology, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi Province, China.
Chinnathambi A; Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia.
Ali Alharbi S; Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia.
Yin F; Department of Cardiology, Xidian Group Hospital, Xi'an, Shaanxi Province, China.
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Źródło :
Environmental toxicology [Environ Toxicol] 2020 Dec; Vol. 35 (12), pp. 1374-1385. Date of Electronic Publication: 2020 Jul 21.
Typ publikacji :
Journal Article
MeSH Terms :
Myocardium*/metabolism
Myocardium*/pathology
Antioxidants/*metabolism
Apoptosis/*drug effects
Doxorubicin/*toxicity
Heart/*drug effects
Naphthoquinones/*pharmacology
Animals ; Apoptosis Regulatory Proteins/metabolism ; Biomarkers/blood ; Cardiotoxicity ; Cytokines/metabolism ; Lipid Peroxidation/drug effects ; Male ; Phosphatidylinositol 3-Kinases/metabolism ; Rats ; Rats, Wistar ; Signal Transduction
Czasopismo naukowe

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