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Wyszukujesz frazę ""Apoptosis/drug effects"" wg kryterium: Temat


Tytuł :
New Method Improves the Evaluation of Subclinical Left Ventricular Dysfunction in Type 2 Diabetes Mellitus
Novo Método Melhora Avaliação da Disfunção Ventricular Esquerda Subclínica no Diabetes Mellitus Tipo 2
Autorzy :
Askin, Lutfu
Tanrıverdi, Okan
Tibilli, Hakan
Turkmen, Serdar
Pokaż więcej
Temat :
Antioxidants/pharmacology
Apoptosis/drug effects
Diabetes Mellitus
Reactive Oxygen Species
Myocardial
Systole
Dyastole
Heart Failure
Antioxidantes/farmacologia
Apoptose/efeitos dos fármacos
Espécies Reativas de Oxigênio
Miocárdio
Sístole
Diástole
Insuficiência Cardíaca
Źródło :
Arquivos Brasileiros de Cardiologia, Volume: 113, Issue: 2, Pages: 216-217, Published: 02 SEP 2019
Opis pliku :
text/html
Tytuł :
An optimized retinoic acid-inducible gene I agonist M8 induces immunogenic cell death markers in human cancer cells and dendritic cell activation
Autorzy :
Castiello, Luciano
Zevini, Alessandra
Vulpis, Elisabetta
Muscolini, Michela
Ferrari, Matteo
Palermo, Enrico
Peruzzi, Giovanna
Krapp, Christian
Jakobsen, Martin
Olagnier, David
Zingoni, Alessandra
Santoni, Angela
Hiscott, John
Pokaż więcej
Temat :
Cell Differentiation
Immunogenic cell death
Interferons/metabolism
Antigen Presentation/drug effects
Proto-Oncogene Proteins c-bcl-2/metabolism
HMGB1 Protein/metabolism
Apoptosis/drug effects
Interferons
Dendritic cells
Alarmins/immunology
BLOCKADE
SUPPRESSION
Calreticulin/metabolism
Molecular Targeted Therapy
RIG-I
Melanoma/drug therapy
Apoptosis Regulatory Proteins/metabolism
Dendritic Cells/immunology
Signal Transduction
Proto-Oncogene Proteins/metabolism
Caspase 3/metabolism
DEAD Box Protein 58/antagonists & inhibitors
Antineoplastic Agents/pharmacology
INTERFERON
ANTIVIRAL RESPONSE
Nelfinavir/analogs & derivatives
Cell Line, Tumor
chemical and pharmacologic phenomena
Immunization
Cancer immunotherapy
DEFECTS
Humans
Źródło :
Castiello, L, Zevini, A, Vulpis, E, Muscolini, M, Ferrari, M, Palermo, E, Peruzzi, G, Krapp, C, Jakobsen, M, Olagnier, D, Zingoni, A, Santoni, A & Hiscott, J 2019, ' An optimized retinoic acid-inducible gene I agonist M8 induces immunogenic cell death markers in human cancer cells and dendritic cell activation ', Cancer Immunology, Immunotherapy, vol. 68, no. 9, pp. 1479-1492 . https://doi.org/10.1007/s00262-019-02380-2
Tytuł :
Hedgehog inhibition mediates radiation sensitivity in mouse xenograft models of human esophageal adenocarcinoma.
Autorzy :
Teichman, Jennifer
Dodbiba, Lorin
Thai, Henry
Fleet, Andrew
Morey, Trevor
Liu, Lucy
McGregor, Madison
Cheng, Dangxiao
Chen, Zhuo
Darling, Gail
Brhane, Yonathan
Song, Yuyao
Espin-Garcia, Osvaldo
Xu, Wei
Girgis, Hala
Schwock, Joerg
MacKay, Helen
Bristow, Robert
Ailles, Laurie
Liu, Geoffrey
Pokaż więcej
Temat :
Cancer Treatment
Digestive System
Animal Models
Pharmaceutics
Radiation Tolerance/drug effects
Gene Expression Regulation, Neoplastic/drug effects
Chemotherapy
Oncology
Mice, SCID
Animals
Xenograft Model Antitumor Assays
Cell Proliferation/drug effects
Biology and Life Sciences
Signal Transduction
Chemoradiotherapy
Hedgehog Signaling
Cancer Chemotherapy
Radiation Therapy
Science
Epithelium
Biphenyl Compounds/pharmacology
Gene Expression
Mouse Models
Research Article
Gastrointestinal Tract
Anatomy
Hedgehog Proteins/antagonists & inhibitors
Mice
Apoptosis/drug effects
Clinical Medicine
Genetics
Biological Tissue
Adenocarcinoma/drug therapy
Esophageal Neoplasms/drug therapy
Pyridines/pharmacology
Clinical Oncology
Experimental Organism Systems
Drug Therapy
Combination Chemotherapy
Research and Analysis Methods
Tumor Cells, Cultured
Medicine
Mice, Inbred NOD
Cell Biology
Model Organisms
Cell Signaling
Medicine and Health Sciences
Humans
Esophagus
Źródło :
Teichman, J, Dodbiba, L, Thai, H, Fleet, A, Morey, T, Liu, L, McGregor, M, Cheng, D, Chen, Z, Darling, G, Brhane, Y, Song, Y, Espin-Garcia, O, Xu, W, Girgis, H, Schwock, J, MacKay, H, Bristow, R, Ailles, L & Liu, G 2018, ' Hedgehog inhibition mediates radiation sensitivity in mouse xenograft models of human esophageal adenocarcinoma ', PLoS ONE, vol. 13, no. 5, pp. e0194809 . https://doi.org/10.1371/journal.pone.0194809
PLoS ONE, Vol 13, Iss 5, p e0194809 (2018)
Tytuł :
LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus
Autorzy :
Pozo, David
Hmadcha, Abdelkrim
Bermúdez-Silva, Francisco-Javier
Gauthier, Benoit R.
Cobo-Vuilleumier, Nadia
Lorenzo, Petra I.
Rodríguez, Noelia García
Herrera Gómez, Irene de Gracia
Fuente-Martin, Esther
López-Noriega, Livia
Mellado-Gil, José Manuel
Romero-Zerbo, Silvana-Yanina
Baquié, Mathurin
Lachaud, Christian Claude
Stifter, Katja
Perdomo, German
Bugliani, Marco
De Tata, Vincenzo
Bosco, Domenico
Parnaud, Geraldine
Florido, Javier P.
Toscano, Miguel G.
de Haan, Peter
Schoonjans, Kristina
Sánchez Palazón, Luis
Marchetti, Piero
Schirmbeck, Reinhold
Martín-Montalvo, Alejandro
Meda, Paolo
Soria, Bernat
St-Onge, Luc
Pokaż więcej
Temat :
Experimental/chemically induced/genetics/immunology/therapy
Endocrinología
Diabetes Mellitus
Phenalenes/pharmacology
Immunity
Chemistry (all)
Biochemistry, Genetics and Molecular Biology (all)
Physics and Astronomy (all)
Mice
Apoptosis/drug effects
Cell Communication/drug effects
Animals
Female
Insulin-Secreting Cells/drug effects/immunology/pathology
Macrophages/drug effects/immunology/pathology
ddc:612
Type 1 diabetes
Receptors
Regulatory/drug effects/immunology/pathology
Type 2/genetics/immunology/pathology
Inbred C57BL
ddc:617
Innate
Islets of Langerhans/drug effects/immunology/pathology
Heterologous
Islets of Langerhans
Article
Gene Expression Regulation
Cell Survival/drug effects
Hypoglycemic Agents/pharmacology
Streptozocin
T-Lymphocytes
Type 2 diabetes
Transplantation
Science
Cytoplasmic and Nuclear/agonists/genetics/immunology
Insulin/metabolism
Islets of Langerhans Transplantation
Humans
Male
Endocrinology
Źródło :
Nature Communications, Vol. 9, No 1 (2018) P. 1488
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Opis pliku :
application/pdf
Tytuł :
Targeting glioma stem-like cell survival and chemoresistance through inhibition of lysine-specific histone demethylase KDM2B
Autorzy :
Mikkel Staberg
Rikke Darling Rasmussen
Signe Regner Michaelsen
Henriette Pedersen
Kamilla Ellermann Jensen
Mette Villingshøj
Jane Skjoth‐Rasmussen
Jannick Brennum
Kristoffer Vitting‐Seerup
Hans Skovgaard Poulsen
Petra Hamerlik
Pokaż więcej
Temat :
Primary Cell Culture
Research Article
Lomustine/administration & dosage
Astrocytes/metabolism
histone demethylase
epigenetics
Research Support, Non-U.S. Gov't
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Apoptosis/drug effects
cancer stem‐like cell
Brain Neoplasms/drug therapy
F-Box Proteins/genetics
Cell Line
Glioblastoma/drug therapy
Neoplastic Stem Cells/metabolism
Lysine/metabolism
DNA Damage/drug effects
Antineoplastic Agents/administration & dosage
chemoresistance
glioblastoma
Drug Resistance, Neoplasm
Jumonji Domain-Containing Histone Demethylases/genetics
RC254-282
Histones/metabolism
Journal Article
Research Articles
Etoposide/administration & dosage
Humans
Źródło :
Molecular Oncology, Vol 12, Iss 3, Pp 406-420 (2018)
Staberg, M, Rasmussen, R D, Michaelsen, S R, Pedersen, H, Jensen, K E, Villingshøj, M, Skjoth-Rasmussen, J, Brennum, J, Vitting-Seerup, K, Poulsen, H S & Hamerlik, P 2018, ' Targeting glioma stem-like cell survival and chemoresistance through inhibition of lysine-specific histone demethylase KDM2B ', Molecular Oncology, vol. 12, no. 3, pp. 406-420 . https://doi.org/10.1002/1878-0261.12174
Opis pliku :
application/pdf
Tytuł :
A Novel Class of Schistosoma mansoni Histone Deacetylase 8 (HDAC8) Inhibitors Identified by Structure-Based Virtual Screening and In Vitro Testing
Autorzy :
Simoben, Conrad
Robaa, Dina
Chakrabarti, Alokta
Schmidtkunz, Karin
Marek, Martin
Lancelot, Julien
Kannan, Srinivasaraghavan
Melesina, Jelena
Shaik, Tajith
Pierce, Raymond
Romier, Christophe
Jung, Manfred
Sippl, Wolfgang
Pokaż więcej
Temat :
crystal structure
docking
epigenetics
histone deacetylase (HDAC) inhibitors
schistosomiasis
virtual screening
MESH: Animals
MESH: Anthelmintics/pharmacology
MESH: Hydroxamic Acids/chemical synthesis
MESH: Hydroxamic Acids/pharmacology
MESH: Apoptosis/drug effects
MESH: Molecular Docking Simulation
MESH: Protein Binding
MESH: Protein Interaction Domains and Motifs
MESH: Protein Structure, Secondary
MESH: Pyrrolidines/chemical synthesis
MESH: Pyrrolidines/pharmacology
MESH: Schistosoma mansoni/drug effects
MESH: Helminth Proteins/chemistry
MESH: Schistosoma mansoni/enzymology
MESH: Schistosoma mansoni/genetics
MESH: Schistosoma mansoni/growth & development
MESH: Binding Sites
MESH: Structure-Activity Relationship
MESH: Zinc/chemistry
MESH: Zinc/metabolism
MESH: Chelating Agents/chemical synthesis
MESH: Anthelmintics/chemical synthesis
MESH: Chelating Agents/pharmacology
MESH: Helminth Proteins/genetics
MESH: Crystallography, X-Ray
MESH: Gene Expression
MESH: Helminth Proteins/antagonists & inhibitors
MESH: Helminth Proteins/metabolism
MESH: Histone Deacetylase Inhibitors/chemical synthesis
MESH: Histone Deacetylase Inhibitors/pharmacology
MESH: Histone Deacetylases/chemistry
MESH: Histone Deacetylases/genetics
MESH: Histone Deacetylases/metabolism
[SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biomolecules [q-bio.BM]
Źródło :
Molecules, MDPI, 2018, 23 (3), pp.566. ⟨10.3390/molecules23030566⟩
Tytuł :
A Novel Class of Schistosoma mansoni Histone Deacetylase 8 (HDAC8) Inhibitors Identified by Structure-Based Virtual Screening and In Vitro Testing
Autorzy :
Conrad V. Simoben
Dina Robaa
Alokta Chakrabarti
Karin Schmidtkunz
Martin Marek
Julien Lancelot
Srinivasaraghavan Kannan
Jelena Melesina
Tajith B. Shaik
Raymond J. Pierce
Christophe Romier
Manfred Jung
Wolfgang Sippl
Pokaż więcej
Temat :
MESH: Molecular Docking Simulation
MESH: Animals
virtual screening
MESH: Schistosoma mansoni/genetics
MESH: Schistosoma mansoni/growth & development
QD241-441
MESH: Schistosoma mansoni/drug effects
MESH: Crystallography, X-Ray
MESH: Histone Deacetylases/genetics
MESH: Pyrrolidines/chemical synthesis
MESH: Hydroxamic Acids/pharmacology
MESH: Schistosoma mansoni/enzymology
epigenetics
MESH: Helminth Proteins/metabolism
MESH: Binding Sites
MESH: Histone Deacetylase Inhibitors/pharmacology
Organic chemistry
MESH: Helminth Proteins/antagonists & inhibitors
MESH: Zinc/chemistry
MESH: Histone Deacetylase Inhibitors/chemical synthesis
MESH: Zinc/metabolism
schistosomiasis
MESH: Hydroxamic Acids/chemical synthesis
histone deacetylase (HDAC) inhibitors
MESH: Protein Interaction Domains and Motifs
MESH: Histone Deacetylases/metabolism
MESH: Protein Structure, Secondary
MESH: Apoptosis/drug effects
MESH: Chelating Agents/chemical synthesis
MESH: Gene Expression
[SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biomolecules [q-bio.BM]
Article
MESH: Anthelmintics/pharmacology
MESH: Helminth Proteins/genetics
docking
MESH: Protein Binding
MESH: Helminth Proteins/chemistry
MESH: Pyrrolidines/pharmacology
crystal structure
MESH: Histone Deacetylases/chemistry
MESH: Structure-Activity Relationship
MESH: Anthelmintics/chemical synthesis
MESH: Chelating Agents/pharmacology
Źródło :
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Molecules, Vol 23, Iss 3, p 566 (2018)
Molecules, MDPI, 2018, 23 (3), pp.566. ⟨10.3390/molecules23030566⟩

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