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Wyszukujesz frazę ""Arachidonate 5-Lipoxygenase"" wg kryterium: Temat


Tytuł :
Design, Synthesis, and Structure-Activity Relationship Studies of Dual Inhibitors of Soluble Epoxide Hydrolase and 5-Lipoxygenase.
Autorzy :
Hiesinger K; Institute of Pharmaceutical Chemistry, Goethe-University of Frankfurt, Max-von-Laue Str. 9 D-60438 Frankfurt a.M., Germany.
Kramer JS; Institute of Pharmaceutical Chemistry, Goethe-University of Frankfurt, Max-von-Laue Str. 9 D-60438 Frankfurt a.M., Germany.
Beyer S; Institute of General Pharmacology and Toxicology, Pharmazentrum Frankfurt, ZAFES, Theodor-Stern-Kai 7, D-60590 Frankfurt a.M., Germany.
Eckes T; Institute of General Pharmacology and Toxicology, Pharmazentrum Frankfurt, ZAFES, Theodor-Stern-Kai 7, D-60590 Frankfurt a.M., Germany.
Brunst S; Institute of Pharmaceutical Chemistry, Goethe-University of Frankfurt, Max-von-Laue Str. 9 D-60438 Frankfurt a.M., Germany.
Flauaus C; Institute of Pharmacology and Clinical Pharmacy, Goethe-University of Frankfurt, Max-von-Laue Str. 9, D-60438 Frankfurt a.M., Germany.
Wittmann SK; Institute of Pharmaceutical Chemistry, Goethe-University of Frankfurt, Max-von-Laue Str. 9 D-60438 Frankfurt a.M., Germany.
Weizel L; Institute of Pharmaceutical Chemistry, Goethe-University of Frankfurt, Max-von-Laue Str. 9 D-60438 Frankfurt a.M., Germany.
Kaiser A; Institute of Pharmaceutical Chemistry, Goethe-University of Frankfurt, Max-von-Laue Str. 9 D-60438 Frankfurt a.M., Germany.
Kretschmer SBM; Institute of Pharmaceutical Chemistry, Goethe-University of Frankfurt, Max-von-Laue Str. 9 D-60438 Frankfurt a.M., Germany.
George S; Institute of Pharmaceutical Chemistry, Goethe-University of Frankfurt, Max-von-Laue Str. 9 D-60438 Frankfurt a.M., Germany.
Angioni C; Institute of Clinical Pharmacology, Pharmazentrum Frankfurt, ZAFES, Theodor-Stern-Kai 7, D-60590 Frankfurt a.M., Germany.
Heering J; Branch for Translational Medicine and Pharmacology, Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Theodor-Stern-Kai 7, D-60590 Frankfurt a.M., Germany.
Geisslinger G; Institute of Clinical Pharmacology, Pharmazentrum Frankfurt, ZAFES, Theodor-Stern-Kai 7, D-60590 Frankfurt a.M., Germany.; Branch for Translational Medicine and Pharmacology, Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Theodor-Stern-Kai 7, D-60590 Frankfurt a.M., Germany.
Schubert-Zsilavecz M; Institute of Pharmaceutical Chemistry, Goethe-University of Frankfurt, Max-von-Laue Str. 9 D-60438 Frankfurt a.M., Germany.
Schmidtko A; Institute of Pharmacology and Clinical Pharmacy, Goethe-University of Frankfurt, Max-von-Laue Str. 9, D-60438 Frankfurt a.M., Germany.
Pogoryelov D; Institute of Biochemistry, Goethe-University of Frankfurt, Max-von-Laue Str. 9, D-60438 Frankfurt a.M., Germany.
Pfeilschifter J; Institute of General Pharmacology and Toxicology, Pharmazentrum Frankfurt, ZAFES, Theodor-Stern-Kai 7, D-60590 Frankfurt a.M., Germany.
Hofmann B; Institute of Pharmaceutical Chemistry, Goethe-University of Frankfurt, Max-von-Laue Str. 9 D-60438 Frankfurt a.M., Germany.
Steinhilber D; Institute of Pharmaceutical Chemistry, Goethe-University of Frankfurt, Max-von-Laue Str. 9 D-60438 Frankfurt a.M., Germany.; Branch for Translational Medicine and Pharmacology, Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Theodor-Stern-Kai 7, D-60590 Frankfurt a.M., Germany.
Schwalm S; Institute of General Pharmacology and Toxicology, Pharmazentrum Frankfurt, ZAFES, Theodor-Stern-Kai 7, D-60590 Frankfurt a.M., Germany.
Proschak E; Institute of Pharmaceutical Chemistry, Goethe-University of Frankfurt, Max-von-Laue Str. 9 D-60438 Frankfurt a.M., Germany.; Branch for Translational Medicine and Pharmacology, Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Theodor-Stern-Kai 7, D-60590 Frankfurt a.M., Germany.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2020 Oct 22; Vol. 63 (20), pp. 11498-11521. Date of Electronic Publication: 2020 Oct 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Design*
Anti-Inflammatory Agents, Non-Steroidal/*chemical synthesis
Arachidonate 5-Lipoxygenase/*metabolism
Epoxide Hydrolases/*antagonists & inhibitors
Lipoxygenase Inhibitors/*chemical synthesis
Animals ; Anti-Inflammatory Agents, Non-Steroidal/chemistry ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Arachidonate 5-Lipoxygenase/genetics ; Cells, Cultured ; Epoxide Hydrolases/genetics ; Humans ; Lipoxygenase Inhibitors/chemistry ; Lipoxygenase Inhibitors/pharmacology ; Microsomes, Liver/drug effects ; Microsomes, Liver/enzymology ; Molecular Structure ; Neutrophils/drug effects ; Neutrophils/enzymology ; Protein Binding ; Rats ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Dual COX and 5-LOX inhibition by clerodane diterpenes from seeds of Polyalthia longifolia (Sonn.) Thwaites.
Autorzy :
Nguyen HT; Institute of Research and Development, Duy Tan University, Da Nang, 550000, Vietnam.; Faculty of Medicine, Duy Tan University, Da Nang, 550000, Vietnam.
Vu TY; Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, 700000, Vietnam.
Chandi V; Pharmacology Department, AU College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, Andhra Pradesh, 530003, India.
Polimati H; Pharmacology Department, AU College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, Andhra Pradesh, 530003, India.; Pharmacology and Toxicology Division, Incozen Therapeutics Pvt Ltd., Turkapally, Telangana, 500078, India.
Tatipamula VB; Institute of Research and Development, Duy Tan University, Da Nang, 550000, Vietnam. .; Faculty of Medicine, Duy Tan University, Da Nang, 550000, Vietnam. .
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Źródło :
Scientific reports [Sci Rep] 2020 Sep 29; Vol. 10 (1), pp. 15965. Date of Electronic Publication: 2020 Sep 29.
Typ publikacji :
Journal Article
MeSH Terms :
Arachidonate 5-Lipoxygenase/*metabolism
Cyclooxygenase 1/*metabolism
Cyclooxygenase 2/*metabolism
Diterpenes, Clerodane/*pharmacology
Polyalthia/*chemistry
Arachidonate 5-Lipoxygenase/chemistry ; Computer Simulation ; Cyclooxygenase 1/chemistry ; Cyclooxygenase 2/chemistry ; Cyclooxygenase Inhibitors/chemistry ; Cyclooxygenase Inhibitors/pharmacology ; Diterpenes, Clerodane/chemistry ; Humans ; Lipoxygenase Inhibitors/chemistry ; Lipoxygenase Inhibitors/pharmacology ; Models, Molecular ; Molecular Docking Simulation ; Molecular Structure ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Seeds/chemistry
Czasopismo naukowe
Tytuł :
Igniting the spread of ferroptotic cell death.
Autorzy :
Davidson AJ; Centre for Inflammation Research, University of Edinburgh, Queens Medical Research Institute, Edinburgh, UK.
Wood W; Centre for Inflammation Research, University of Edinburgh, Queens Medical Research Institute, Edinburgh, UK. .
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Źródło :
Nature cell biology [Nat Cell Biol] 2020 Sep; Vol. 22 (9), pp. 1027-1029.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Arachidonate 5-Lipoxygenase*
Lipid Peroxidation*
Animals ; Cell Death ; Reactive Oxygen Species ; Zebrafish
Czasopismo naukowe
Tytuł :
Long-term stimulation of toll-like receptor-2 and -4 upregulates 5-LO and 15-LO-2 expression thereby inducing a lipid mediator shift in human monocyte-derived macrophages.
Autorzy :
Ebert R; Institute of Pharmaceutical Chemistry/ZAFES, Max-von-Laue-Straße 9, Goethe University, 60438 Frankfurt/Main, Germany.
Cumbana R; Institute of Pharmaceutical Chemistry/ZAFES, Max-von-Laue-Straße 9, Goethe University, 60438 Frankfurt/Main, Germany.
Lehmann C; Project Group Translational Medicine and Pharmacology TMP, Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Theodor-Stern-Kai 7, 60596 Frankfurt/Main, Germany.
Kutzner L; Food Chemistry, Faculty of Mathematics and Natural Sciences, University of Wuppertal, Gaußstraße 20, 42119 Wuppertal, Germany.
Toewe A; Pharmazentrum Frankfurt/ZAFES, Institute of Clinical Pharmacology, Goethe-University, Theodor-Stern-Kai 7, 60590 Frankfurt/Main, Germany.
Ferreirós N; Pharmazentrum Frankfurt/ZAFES, Institute of Clinical Pharmacology, Goethe-University, Theodor-Stern-Kai 7, 60590 Frankfurt/Main, Germany.
Parnham MJ; Project Group Translational Medicine and Pharmacology TMP, Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Theodor-Stern-Kai 7, 60596 Frankfurt/Main, Germany.
Schebb NH; Food Chemistry, Faculty of Mathematics and Natural Sciences, University of Wuppertal, Gaußstraße 20, 42119 Wuppertal, Germany.
Steinhilber D; Institute of Pharmaceutical Chemistry/ZAFES, Max-von-Laue-Straße 9, Goethe University, 60438 Frankfurt/Main, Germany.
Kahnt AS; Institute of Pharmaceutical Chemistry/ZAFES, Max-von-Laue-Straße 9, Goethe University, 60438 Frankfurt/Main, Germany. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Molecular and cell biology of lipids [Biochim Biophys Acta Mol Cell Biol Lipids] 2020 Sep; Vol. 1865 (9), pp. 158702. Date of Electronic Publication: 2020 Mar 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Arachidonate 15-Lipoxygenase/*metabolism
Arachidonate 5-Lipoxygenase/*metabolism
Macrophages/*metabolism
Toll-Like Receptor 2/*metabolism
Toll-Like Receptor 4/*metabolism
Arachidonate 15-Lipoxygenase/genetics ; Arachidonate 5-Lipoxygenase/genetics ; Cells, Cultured ; Cyclooxygenase 2/metabolism ; Cytokines/metabolism ; Humans ; Lipid Metabolism ; Lipopolysaccharides/pharmacology ; Macrophages/drug effects
Czasopismo naukowe
Tytuł :
Structural and mechanistic insights into 5-lipoxygenase inhibition by natural products.
Autorzy :
Gilbert NC; Department of Biological Sciences, Louisiana State University, Baton Rouge, LA, USA.
Gerstmeier J; Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich-Schiller-University, Jena, Germany.
Schexnaydre EE; Department of Biological Sciences, Louisiana State University, Baton Rouge, LA, USA.
Börner F; Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich-Schiller-University, Jena, Germany.
Garscha U; Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich-Schiller-University, Jena, Germany.
Neau DB; Cornell University, Northeastern Collaborative Access Team, Argonne National Laboratory, Argonne, IL, USA.
Werz O; Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich-Schiller-University, Jena, Germany. .
Newcomer ME; Department of Biological Sciences, Louisiana State University, Baton Rouge, LA, USA. .
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Źródło :
Nature chemical biology [Nat Chem Biol] 2020 Jul; Vol. 16 (7), pp. 783-790. Date of Electronic Publication: 2020 May 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Arachidonate 5-Lipoxygenase/*chemistry
Biological Products/*chemistry
Lipoxygenase Inhibitors/*chemistry
Masoprocol/*chemistry
Triterpenes/*chemistry
Allosteric Site ; Arachidonate 5-Lipoxygenase/genetics ; Arachidonate 5-Lipoxygenase/metabolism ; Biological Products/metabolism ; Catalytic Domain ; Cloning, Molecular ; Crystallography, X-Ray ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Gene Expression ; Genetic Vectors/chemistry ; Genetic Vectors/metabolism ; Humans ; Hydroxyeicosatetraenoic Acids/chemistry ; Hydroxyeicosatetraenoic Acids/metabolism ; Leukotriene B4/chemistry ; Leukotriene B4/metabolism ; Lipoxygenase Inhibitors/metabolism ; Masoprocol/metabolism ; Models, Molecular ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Interaction Domains and Motifs ; Protein Multimerization ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Substrate Specificity ; Triterpenes/metabolism
Czasopismo naukowe
Tytuł :
5-LOX inhibition by natural products.
Autorzy :
Rubbo H; Departamento de Bioquímica, Facultad de Medicina, Universidad de la República and Centro de Investigaciones Biomédicas (CEINBIO), Montevideo, Uruguay. .
Wood I; Departamento de Bioquímica, Facultad de Medicina, Universidad de la República and Centro de Investigaciones Biomédicas (CEINBIO), Montevideo, Uruguay.
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Źródło :
Nature chemical biology [Nat Chem Biol] 2020 Jul; Vol. 16 (7), pp. 714-715.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Arachidonate 5-Lipoxygenase*
Biological Products*
Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
The role of propofol hydroxyl group in 5-lipoxygenase recognition.
Autorzy :
Yuki K; Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, 02115, USA; Department of Anaesthesia, Harvard Medical School, Boston, MA, 02115, USA. Electronic address: .
Bu W; Department of Anesthesiology and Critical Care, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Eckenhoff RG; Department of Anesthesiology and Critical Care, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Yokomizo T; Department of Biochemistry, Juntendo University Faculty of Medicine, Bunkyo-Ku, Tokyo, 113-8421, Japan.
Okuno T; Department of Biochemistry, Juntendo University Faculty of Medicine, Bunkyo-Ku, Tokyo, 113-8421, Japan. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2020 May 14; Vol. 525 (4), pp. 909-914. Date of Electronic Publication: 2020 Mar 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Arachidonate 5-Lipoxygenase/*metabolism
Propofol/*chemistry
Propofol/*metabolism
Anesthetics, Intravenous/chemistry ; Anesthetics, Intravenous/metabolism ; Arachidonate 5-Lipoxygenase/chemistry ; Arachidonate 5-Lipoxygenase/genetics ; Arachidonic Acid/blood ; Binding Sites ; Calcimycin/pharmacology ; Calcium Ionophores/pharmacology ; HEK293 Cells ; Humans ; Leukotriene B4/metabolism ; Leukotrienes/metabolism ; Lipoxygenase Inhibitors/chemistry ; Lipoxygenase Inhibitors/metabolism ; Molecular Docking Simulation ; Mutagenesis ; Propofol/pharmacology ; Protein Conformation ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Two- and three-color STORM analysis reveals higher-order assembly of leukotriene synthetic complexes on the nuclear envelope of murine neutrophils.
Autorzy :
Schmider AB; Nephrology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129.
Bauer NC; Nephrology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129.
Sunwoo H; Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114.
Godin MD; Nephrology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129.
Ellis GE; Nephrology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129.
Lee JT; Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114.; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115.
Nigrovic PA; Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, Massachusetts 02115.
Soberman RJ; Nephrology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129 .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2020 Apr 24; Vol. 295 (17), pp. 5761-5770. Date of Electronic Publication: 2020 Mar 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
5-Lipoxygenase-Activating Proteins/*metabolism
Arachidonate 5-Lipoxygenase/*metabolism
Leukotriene C4/*metabolism
Neutrophils/*metabolism
5-Lipoxygenase-Activating Proteins/analysis ; Algorithms ; Animals ; Arachidonate 5-Lipoxygenase/analysis ; Cell Nucleus/metabolism ; Cells, Cultured ; Leukotriene C4/analysis ; Mice ; Mice, Inbred C57BL ; Microscopy/methods ; Neutrophils/cytology ; Optical Imaging/methods
Czasopismo naukowe
Tytuł :
Pharmacological and genetic targeting of 5-lipoxygenase interrupts c-Myc oncogenic signaling and kills enzalutamide-resistant prostate cancer cells via apoptosis.
Autorzy :
Monga J; Vattikuti Urology Institute, Henry Ford Health System, Detroit, MI, 48202, United States.
Subramani D; Vattikuti Urology Institute, Henry Ford Health System, Detroit, MI, 48202, United States.
Bharathan A; Vattikuti Urology Institute, Henry Ford Health System, Detroit, MI, 48202, United States.
Ghosh J; Vattikuti Urology Institute, Henry Ford Health System, Detroit, MI, 48202, United States. .; Henry Ford Cancer Institute, Henry Ford Health System, Detroit, MI, 48202, United States. .
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Źródło :
Scientific reports [Sci Rep] 2020 Apr 20; Vol. 10 (1), pp. 6649. Date of Electronic Publication: 2020 Apr 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Neoplastic*
5-Lipoxygenase-Activating Protein Inhibitors/*pharmacology
Antineoplastic Agents/*pharmacology
Arachidonate 5-Lipoxygenase/*genetics
Indoles/*pharmacology
Phenylthiohydantoin/*analogs & derivatives
Proto-Oncogene Proteins c-myc/*genetics
Quinolines/*pharmacology
Apoptosis/drug effects ; Apoptosis/genetics ; Arachidonate 5-Lipoxygenase/metabolism ; Cell Line ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Drug Resistance, Neoplasm/drug effects ; Drug Resistance, Neoplasm/genetics ; Fibroblasts/cytology ; Fibroblasts/drug effects ; Fibroblasts/metabolism ; Humans ; Male ; Organ Specificity ; Phenylthiohydantoin/pharmacology ; Prostate/metabolism ; Prostate/pathology ; Proto-Oncogene Proteins c-myc/metabolism ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
Cutting Edge: Severe SARS-CoV-2 Infection in Humans Is Defined by a Shift in the Serum Lipidome, Resulting in Dysregulation of Eicosanoid Immune Mediators.
Autorzy :
Schwarz B; Laboratory of Bacteriology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840.
Sharma L; Section of Pulmonary and Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, CT 06520.
Roberts L; Laboratory of Bacteriology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840.
Peng X; Section of Pulmonary and Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, CT 06520.
Bermejo S; Section of Pulmonary and Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, CT 06520.
Leighton I; Laboratory of Bacteriology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840.
Casanovas-Massana A; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06520; and.
Minasyan M; Section of Pulmonary and Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, CT 06520.
Farhadian S; Section of Infectious Diseases, Department of Medicine, Yale University School of Medicine, New Haven, CT 06520.
Ko AI; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06520; and.
Dela Cruz CS; Section of Pulmonary and Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, CT 06520; .
Bosio CM; Laboratory of Bacteriology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840; .
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Corporate Authors :
Yale IMPACT Team
Źródło :
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2021 Jan 15; Vol. 206 (2), pp. 329-334. Date of Electronic Publication: 2020 Dec 04.
Typ publikacji :
Clinical Trial; Journal Article; Research Support, N.I.H., Intramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
COVID-19*/blood
COVID-19*/immunology
Eicosanoids*/blood
Eicosanoids*/immunology
Lipidomics*
SARS-CoV-2*/immunology
SARS-CoV-2*/metabolism
Adult ; Aged ; Aged, 80 and over ; Arachidonate 12-Lipoxygenase/immunology ; Arachidonate 12-Lipoxygenase/metabolism ; Arachidonate 5-Lipoxygenase/immunology ; Arachidonate 5-Lipoxygenase/metabolism ; Biomarkers/blood ; Cyclooxygenase 2/immunology ; Cyclooxygenase 2/metabolism ; Female ; Humans ; Male ; Middle Aged
Czasopismo naukowe
Tytuł :
Protective activities of distinct omega-3 enriched oils are linked to their ability to upregulate specialized pro-resolving mediators.
Autorzy :
Sobrino A; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Walker ME; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Colas RA; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Dalli J; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.; Centre for Inflammation and Therapeutic Innovation, Queen Mary University of London, London, United Kingdom.
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Źródło :
PloS one [PLoS One] 2020 Dec 16; Vol. 15 (12), pp. e0242543. Date of Electronic Publication: 2020 Dec 16 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Dietary Supplements*
Atherosclerosis/*prevention & control
Fatty Acids, Omega-3/*administration & dosage
Leukotrienes/*biosynthesis
Lipoxins/*biosynthesis
Macrophages/*drug effects
Prostaglandins/*biosynthesis
Animals ; Apolipoproteins E/deficiency ; Apolipoproteins E/genetics ; Apolipoproteins E/immunology ; Arachidonate 15-Lipoxygenase/genetics ; Arachidonate 15-Lipoxygenase/immunology ; Arachidonate 5-Lipoxygenase/genetics ; Arachidonate 5-Lipoxygenase/immunology ; Atherosclerosis/etiology ; Atherosclerosis/immunology ; Atherosclerosis/metabolism ; Diet, Western/adverse effects ; Fatty Acids, Omega-3/metabolism ; Female ; Gene Expression ; Humans ; Leukotrienes/immunology ; Lipoproteins, LDL/antagonists & inhibitors ; Lipoproteins, LDL/pharmacology ; Lipoxins/immunology ; Lipoxygenase Inhibitors/pharmacology ; Macrophages/cytology ; Macrophages/immunology ; Male ; Mice ; Mice, Knockout, ApoE ; Phagocytosis/drug effects ; Primary Cell Culture ; Principal Component Analysis ; Prostaglandins/immunology
Czasopismo naukowe
Tytuł :
First report of antioxidative 2H -chromenyl derivatives from the intertidal red seaweed Gracilaria salicornia as potential anti-inflammatory agents.
Autorzy :
Antony T; Central Marine Fisheries Research Institute, Cochin, India.; Department of Chemistry, Mangalore University, Mangalagangothri, Karnataka State, India.
Chakraborty K; Central Marine Fisheries Research Institute, Cochin, India.
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Źródło :
Natural product research [Nat Prod Res] 2020 Dec; Vol. 34 (24), pp. 3470-3482. Date of Electronic Publication: 2019 Mar 19.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Inflammatory Agents, Non-Steroidal/*pharmacology
Antioxidants/*pharmacology
Gracilaria/*chemistry
Anti-Inflammatory Agents, Non-Steroidal/chemistry ; Antioxidants/chemistry ; Arachidonate 5-Lipoxygenase/chemistry ; Arachidonate 5-Lipoxygenase/metabolism ; Benzopyrans/chemistry ; Cyclooxygenase 2/metabolism ; Cyclooxygenase 2 Inhibitors/chemistry ; Cyclooxygenase 2 Inhibitors/pharmacology ; Drug Evaluation, Preclinical ; Hydrogen Bonding ; Lipoxygenase Inhibitors/chemistry ; Lipoxygenase Inhibitors/pharmacology ; Molecular Docking Simulation ; Molecular Structure ; Plant Extracts/chemistry ; Seaweed/chemistry
Czasopismo naukowe
Tytuł :
Synthesis and structure-activity relationships of novel 5-(hydroxamic acid)methyl oxazolidinone derivatives as 5-lipoxygenase inhibitors.
Autorzy :
Phillips OA; Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Kuwait University, Safat, Kuwait.
Bosso MA; Faculty of Medicine, Department of Pharmacology & Toxicology, Kuwait University, Safat, Kuwait.
Ezeamuzie CI; Faculty of Medicine, Department of Pharmacology & Toxicology, Kuwait University, Safat, Kuwait.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2020 Dec; Vol. 35 (1), pp. 1471-1482.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Inflammatory Agents, Non-Steroidal/*pharmacology
Arachidonate 5-Lipoxygenase/*metabolism
Hydroxamic Acids/*pharmacology
Inflammation/*drug therapy
Lipoxygenase Inhibitors/*pharmacology
Oxazolidinones/*pharmacology
Animals ; Anti-Inflammatory Agents, Non-Steroidal/chemical synthesis ; Anti-Inflammatory Agents, Non-Steroidal/chemistry ; Cell Line ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Female ; Humans ; Hydroxamic Acids/chemical synthesis ; Hydroxamic Acids/chemistry ; Inflammation/chemically induced ; Inflammation/metabolism ; Leukotriene B4/antagonists & inhibitors ; Leukotriene B4/biosynthesis ; Lipoxygenase Inhibitors/chemical synthesis ; Lipoxygenase Inhibitors/chemistry ; Male ; Mice ; Mice, Inbred BALB C ; Molecular Structure ; Oxazolidinones/chemical synthesis ; Oxazolidinones/chemistry ; Structure-Activity Relationship ; Zymosan
Czasopismo naukowe
Tytuł :
Mutations of Triad Determinants Changes the Substrate Alignment at the Catalytic Center of Human ALOX5.
Autorzy :
Ivanov I; Lomonosov Institute of Fine Chemical Technologies , MIREA - Russian Technological University , Vernadskogo pr. 86 , 119571 Moscow , Russia.
Golovanov AB; Lomonosov Institute of Fine Chemical Technologies , MIREA - Russian Technological University , Vernadskogo pr. 86 , 119571 Moscow , Russia.
Ferretti C
Canyelles-Niño M
Heydeck D; Institute of Biochemistry , Charite - University Medicine Berlin, Corporate member of Free University Berlin, Humboldt University Berlin, and Berlin Institute of Health , Charitéplatz 1 , D-10117 Berlin , Germany.
Stehling S; Institute of Biochemistry , Charite - University Medicine Berlin, Corporate member of Free University Berlin, Humboldt University Berlin, and Berlin Institute of Health , Charitéplatz 1 , D-10117 Berlin , Germany.
Lluch JM
González-Lafont À
Kühn H; Institute of Biochemistry , Charite - University Medicine Berlin, Corporate member of Free University Berlin, Humboldt University Berlin, and Berlin Institute of Health , Charitéplatz 1 , D-10117 Berlin , Germany.
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Źródło :
ACS chemical biology [ACS Chem Biol] 2019 Dec 20; Vol. 14 (12), pp. 2768-2782. Date of Electronic Publication: 2019 Nov 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mutation*
Arachidonate 5-Lipoxygenase/*metabolism
Animals ; Arachidonate 5-Lipoxygenase/chemistry ; Arachidonic Acid/metabolism ; Catalytic Domain ; Humans ; Linoleic Acid/metabolism ; Molecular Docking Simulation ; Oxygen/metabolism ; Sf9 Cells ; Substrate Specificity
Czasopismo naukowe
Tytuł :
Exploring Biological Activity of 4-Oxo-4 H -furo[2,3- h ]chromene Derivatives as Potential Multi-Target-Directed Ligands Inhibiting Cholinesterases, β-Secretase, Cyclooxygenase-2, and Lipoxygenase-5/15.
Autorzy :
Mphahlele MJ; Department of Chemistry, College of Science, Engineering and Technology, University of South Africa, Private Bag X06, Florida 1710, South Africa.
Agbo EN; Department of Chemistry, College of Science, Engineering and Technology, University of South Africa, Private Bag X06, Florida 1710, South Africa.
Gildenhuys S; Department of Life & Consumer Sciences, College of Agriculture and Environmental Sciences, University of South Africa, Private Bag X06, Florida 1710, South Africa.
Setshedi IB; Department of Life & Consumer Sciences, College of Agriculture and Environmental Sciences, University of South Africa, Private Bag X06, Florida 1710, South Africa.
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Źródło :
Biomolecules [Biomolecules] 2019 Nov 13; Vol. 9 (11). Date of Electronic Publication: 2019 Nov 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amyloid Precursor Protein Secretases*/antagonists & inhibitors
Amyloid Precursor Protein Secretases*/chemistry
Amyloid Precursor Protein Secretases*/metabolism
Arachidonate 5-Lipoxygenase*/chemistry
Arachidonate 5-Lipoxygenase*/metabolism
Cholinesterase Inhibitors*/chemistry
Cholinesterase Inhibitors*/pharmacology
Cholinesterases*/chemistry
Cholinesterases*/metabolism
Cyclooxygenase 2*/chemistry
Cyclooxygenase 2*/metabolism
Cyclooxygenase 2 Inhibitors*/chemistry
Lipoxygenase Inhibitors*/chemistry
Lipoxygenase Inhibitors*/pharmacology
HEK293 Cells ; Humans ; Ligands ; MCF-7 Cells ; Molecular Docking Simulation
Czasopismo naukowe
Tytuł :
Characterization of spirostanol glycosides and furostanol glycosides from anemarrhenae rhizoma as dual targeted inhibitors of 5-lipoxygenase and Cyclooxygenase-2 by employing a combination of affinity ultrafiltration and HPLC/MS.
Autorzy :
Xie L; School of Pharmacy, Department of Pharmaceutical Analysis, Shenyang Pharmaceutical University, Shenyang 110016, China.
Lee DY; Mailman Research Center, McLean Hospital, Harvard Medical School, Boston, MA, United States. Electronic address: .
Shang Y; School of Pharmacy, Department of Pharmaceutical Analysis, Shenyang Pharmaceutical University, Shenyang 110016, China.
Cao X; School of Pharmacy, Department of Pharmaceutical Analysis, Shenyang Pharmaceutical University, Shenyang 110016, China.
Wang S; School of Pharmacy, Department of Pharmaceutical Analysis, Shenyang Pharmaceutical University, Shenyang 110016, China.
Liao J; School of Pharmacy, Department of Pharmaceutical Analysis, Shenyang Pharmaceutical University, Shenyang 110016, China.
Zhang T; School of Pharmacy, Department of Pharmaceutical Analysis, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address: .
Dai R; School of Pharmacy, Department of Pharmaceutical Analysis, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address: .
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Źródło :
Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2020 Oct; Vol. 77, pp. 153284. Date of Electronic Publication: 2020 Jul 11.
Typ publikacji :
Journal Article
MeSH Terms :
Anemarrhena/*chemistry
Cyclooxygenase 2 Inhibitors/*pharmacology
Glycosides/*chemistry
Lipoxygenase Inhibitors/*pharmacology
Spirostans/*chemistry
Sterols/*chemistry
Animals ; Anti-Inflammatory Agents, Non-Steroidal/chemistry ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Arachidonate 5-Lipoxygenase/chemistry ; Arachidonate 5-Lipoxygenase/genetics ; Arachidonate 5-Lipoxygenase/metabolism ; Chromatography, High Pressure Liquid ; Cyclooxygenase 2/chemistry ; Cyclooxygenase 2/genetics ; Cyclooxygenase 2/metabolism ; Cyclooxygenase 2 Inhibitors/chemistry ; Drug Evaluation, Preclinical ; Glycosides/pharmacology ; Inflammation/drug therapy ; Lipoxygenase Inhibitors/chemistry ; Mass Spectrometry ; Molecular Docking Simulation ; Rats ; Rhizome/chemistry ; Saponins/chemistry ; Saponins/pharmacology ; Spirostans/pharmacology ; Steroids/chemistry ; Steroids/pharmacology ; Sterols/pharmacology ; Ultrafiltration
Czasopismo naukowe
Tytuł :
Emerging Roles of 5-Lipoxygenase Phosphorylation in Inflammation and Cell Death.
Autorzy :
Sun QY; Department of Clinical Pharmacology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha 410008, China.; Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, 110 Xiangya Road, Changsha 410078, China.; Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, 110 Xiangya Road, Changsha 410078, China.; National Clinical Research Center for Geriatric Disorders, 87 Xiangya Road, Changsha, 410008 Hunan, China.
Zhou HH; Department of Clinical Pharmacology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha 410008, China.; Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, 110 Xiangya Road, Changsha 410078, China.; Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, 110 Xiangya Road, Changsha 410078, China.; National Clinical Research Center for Geriatric Disorders, 87 Xiangya Road, Changsha, 410008 Hunan, China.
Mao XY; Department of Clinical Pharmacology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha 410008, China.; Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, 110 Xiangya Road, Changsha 410078, China.; Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, 110 Xiangya Road, Changsha 410078, China.; National Clinical Research Center for Geriatric Disorders, 87 Xiangya Road, Changsha, 410008 Hunan, China.
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Źródło :
Oxidative medicine and cellular longevity [Oxid Med Cell Longev] 2019 Nov 29; Vol. 2019, pp. 2749173. Date of Electronic Publication: 2019 Nov 29 (Print Publication: 2019).
Typ publikacji :
Journal Article; Review
MeSH Terms :
Arachidonate 5-Lipoxygenase/*metabolism
Cell Death/*physiology
Inflammation/*metabolism
Animals ; Arachidonate 5-Lipoxygenase/genetics ; Cell Death/genetics ; Humans ; Inflammation/genetics ; Phosphorylation/genetics ; Phosphorylation/physiology
Czasopismo naukowe
Tytuł :
Leukotriene Synthesis Is Critical for Medulloblastoma Progression.
Autorzy :
Du F; Laboratory of Molecular Neuropathology, College of Pharmaceutical Sciences, Soochow University, Suzhou, China.; Cancer Biology Program, Fox Chase Cancer Center, Temple University Health System, Philadelphia, Pennsylvania.
Yuelling L; Cancer Biology Program, Fox Chase Cancer Center, Temple University Health System, Philadelphia, Pennsylvania.
Lee EH; Cancer Biology Program, Fox Chase Cancer Center, Temple University Health System, Philadelphia, Pennsylvania.
Wang Y; Laboratory of Molecular Neuropathology, College of Pharmaceutical Sciences, Soochow University, Suzhou, China.
Liao S; Laboratory of Molecular Neuropathology, College of Pharmaceutical Sciences, Soochow University, Suzhou, China.
Cheng Y; Laboratory of Molecular Neuropathology, College of Pharmaceutical Sciences, Soochow University, Suzhou, China.; Cancer Biology Program, Fox Chase Cancer Center, Temple University Health System, Philadelphia, Pennsylvania.
Zhang L; Laboratory of Molecular Neuropathology, College of Pharmaceutical Sciences, Soochow University, Suzhou, China.
Zheng C; Laboratory of Molecular Neuropathology, College of Pharmaceutical Sciences, Soochow University, Suzhou, China.
Peri S; Biostatistics and Bioinformatics Research Facility, Fox Chase Cancer Center, Temple University Health System, Philadelphia, Pennsylvania.
Cai KQ; Cancer Biology Program, Fox Chase Cancer Center, Temple University Health System, Philadelphia, Pennsylvania.
Ng JMY; Children's Research Institute, Children's Mercy Kansas City, Kansas City, Missouri.
Curran T; Children's Research Institute, Children's Mercy Kansas City, Kansas City, Missouri.
Li P; Department of Pharmacognosy and Traditional Chinese Pharmacology, College of Pharmacy, Army Medical University, Chongqing, China.
Yang ZJ; Cancer Biology Program, Fox Chase Cancer Center, Temple University Health System, Philadelphia, Pennsylvania. .
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Źródło :
Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2019 Nov 01; Vol. 25 (21), pp. 6475-6486. Date of Electronic Publication: 2019 Jul 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Arachidonate 5-Lipoxygenase/*genetics
Carcinogenesis/*genetics
Leukotrienes/*genetics
Medulloblastoma/*genetics
Animals ; Arachidonate 5-Lipoxygenase/deficiency ; Astrocytes/metabolism ; Astrocytes/pathology ; Cell Line, Tumor ; Cell Proliferation/genetics ; Disease Progression ; Gene Expression Regulation, Neoplastic/genetics ; Hedgehog Proteins/genetics ; Humans ; Leukotrienes/biosynthesis ; Medulloblastoma/pathology ; Mice ; Mice, Knockout ; RNA, Small Interfering/genetics ; Signal Transduction/genetics
Czasopismo naukowe
Tytuł :
Discovery of a novel 2,5-dihydroxycinnamic acid-based 5-lipoxygenase inhibitor that induces apoptosis and may impair autophagic flux in RCC4 renal cancer cells.
Autorzy :
Selka A; Department of Chemistry and Biochemistry, Université de Moncton, Moncton, New Brunswick, Canada.
Doiron JA; Department of Chemistry and Biochemistry, Université de Moncton, Moncton, New Brunswick, Canada.
Lyons P; Department of Chemistry and Biochemistry, Université de Moncton, Moncton, New Brunswick, Canada.
Dastous S; Department of Chemistry and Biochemistry, Université de Moncton, Moncton, New Brunswick, Canada.
Chiasson A; Department of Chemistry and Biochemistry, Université de Moncton, Moncton, New Brunswick, Canada.
Cormier M; Department of Chemistry and Biochemistry, Université de Moncton, Moncton, New Brunswick, Canada.
Turcotte S; Department of Chemistry and Biochemistry, Université de Moncton, Moncton, New Brunswick, Canada.
Surette ME; Department of Chemistry and Biochemistry, Université de Moncton, Moncton, New Brunswick, Canada.
Touaibia M; Department of Chemistry and Biochemistry, Université de Moncton, Moncton, New Brunswick, Canada. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2019 Oct 01; Vol. 179, pp. 347-357. Date of Electronic Publication: 2019 Jun 23.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Discovery*
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Arachidonate 5-Lipoxygenase/*metabolism
Carcinoma, Renal Cell/*drug therapy
Kidney Neoplasms/*drug therapy
Lipoxygenase Inhibitors/*pharmacology
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Arachidonate 5-Lipoxygenase/biosynthesis ; Carcinoma, Renal Cell/metabolism ; Carcinoma, Renal Cell/pathology ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Cells, Cultured ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; HEK293 Cells ; Humans ; Kidney Neoplasms/metabolism ; Kidney Neoplasms/pathology ; Lipoxygenase Inhibitors/chemical synthesis ; Lipoxygenase Inhibitors/chemistry ; Molecular Structure ; Neutrophils/drug effects ; Neutrophils/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
5-Lipoxagenase deficiency attenuates L-NAME-induced hypertension and vascular remodeling.
Autorzy :
Chen JX; Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China.
Xue KY; Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China.
Xin JJ; Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China.
Yan X; Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China; Department of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China.
Li RL; Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China.
Wang XX; Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China.
Wang XL; Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China; School of Life Sciences and Bioengineering, Southwest Jiaotong University, Chengdu, Sichuan 610031, PR China.
Tong MM; Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China.
Gan L; Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China.
Li H; Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China.
Lan J; Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China.
Li X; Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China.
Zhuo CL; Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China.
Li LY; Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China.
Deng ZJ; Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China.
Zhang HY; Department of Cardiology, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan 610041, PR China.
Jiang W; Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Molecular basis of disease [Biochim Biophys Acta Mol Basis Dis] 2019 Sep 01; Vol. 1865 (9), pp. 2379-2392. Date of Electronic Publication: 2019 Jun 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Vascular Remodeling*/drug effects
Arachidonate 5-Lipoxygenase/*genetics
Hypertension/*prevention & control
Animals ; Aorta/metabolism ; Aorta/pathology ; Arachidonate 5-Lipoxygenase/deficiency ; Blood Pressure/drug effects ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Hypertension/chemically induced ; Hypertension/pathology ; Leukotriene A4/blood ; Leukotriene A4/pharmacology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Muscle, Smooth, Vascular/cytology ; Muscle, Smooth, Vascular/metabolism ; NG-Nitroarginine Methyl Ester/metabolism ; NG-Nitroarginine Methyl Ester/toxicity ; Neutrophils/immunology ; Neutrophils/metabolism ; Nitric Oxide Synthase Type II/metabolism ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe

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