Temat: "Arachidonate 5-Lipoxygenase" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Multi-walled carbon nanotubes induce arachidonate 5-lipoxygenase expression and enhance the polarization and function of M1 macrophages in vitro .
Autorzy:: Lim CS; Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, USA.
Veltri B; Department of Microbiology, Immunology, and Cell Biology, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, WV, USA.
Kashon M; Bioanalytics Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, USA.
Porter DW; Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, USA.
Ma Q; Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, USA.; Pokaż więcej
Źródło:: Nanotoxicology [Nanotoxicology] 2023 Apr; Vol. 17 (3), pp. 249-269. Date of Electronic Publication: 2023 Apr 28.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms:: Arachidonate 5-Lipoxygenase*/genetics
Arachidonate 5-Lipoxygenase*/metabolism
Macrophages*
Nanotubes, Carbon*/toxicity
Animals ; Mice ; Cytokines/metabolism ; Leukotriene B4/metabolism ; Macrophage Activation

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Skocz do pozycji: 2.

Tytuł:: Oncogenic PIK3CA recruits myeloid-derived suppressor cells to shape the immunosuppressive tumour microenvironment in luminal breast cancer through the 5-lipoxygenase-dependent arachidonic acid pathway.
Autorzy:: Li X; Cancer Molecular Diagnostics Core, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Tianjin's Clinical Research Center for Cancer, Tianjin, China.; Key Laboratory of Cancer Immunology and Biotherapy, Tianjin, China.; Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin, China.; Department of Thyroid and Neck, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China.
Chen G; Cancer Molecular Diagnostics Core, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Tianjin's Clinical Research Center for Cancer, Tianjin, China.; Key Laboratory of Cancer Immunology and Biotherapy, Tianjin, China.; Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin, China.
Wang F; Cancer Molecular Diagnostics Core, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Tianjin's Clinical Research Center for Cancer, Tianjin, China.; Key Laboratory of Cancer Immunology and Biotherapy, Tianjin, China.; Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin, China.
Guo X; Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin, China.; Department of Breast Pathology and Lab, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
Zhang R; Cancer Molecular Diagnostics Core, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Tianjin's Clinical Research Center for Cancer, Tianjin, China.; Key Laboratory of Cancer Immunology and Biotherapy, Tianjin, China.; Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin, China.
Liu P; Cancer Molecular Diagnostics Core, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Tianjin's Clinical Research Center for Cancer, Tianjin, China.; Key Laboratory of Cancer Immunology and Biotherapy, Tianjin, China.; Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin, China.
Dong L; Cancer Molecular Diagnostics Core, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Tianjin's Clinical Research Center for Cancer, Tianjin, China.; Key Laboratory of Cancer Immunology and Biotherapy, Tianjin, China.; Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin, China.
Yu W; Key Laboratory of Cancer Immunology and Biotherapy, Tianjin, China.; Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Tianjin, China.
Wang H; College of Life Sciences, Nankai University, Tianjin, China.
Wang H; Laboratory of Cancer Cell Biology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Caner, Tianjin's Clinical Research Center for Cancer, Tianjin, China.; Key Laboratory of Cancer Prevention and Therapy, Tianjin, China.
Yu J; Cancer Molecular Diagnostics Core, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Tianjin's Clinical Research Center for Cancer, Tianjin, China.; Key Laboratory of Cancer Immunology and Biotherapy, Tianjin, China.; Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin, China.; Pokaż więcej
Źródło:: Clinical and translational medicine [Clin Transl Med] 2023 Nov; Vol. 13 (11), pp. e1483.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Breast Neoplasms*/metabolism
Myeloid-Derived Suppressor Cells*
Female ; Humans ; Arachidonate 5-Lipoxygenase/genetics ; Arachidonate 5-Lipoxygenase/metabolism ; Arachidonic Acid/metabolism ; Class I Phosphatidylinositol 3-Kinases/genetics ; Class I Phosphatidylinositol 3-Kinases/metabolism ; Immunosuppressive Agents ; Leukotriene B4/metabolism ; Phosphatidylinositol 3-Kinases/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Tumor Microenvironment

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Skocz do pozycji: 3.

Tytuł:: Cancer-educated neutrophils promote lung cancer progression via PARP-1-ALOX5-mediated MMP-9 expression.
Autorzy:: Han L; Cancer Institute, Xuzhou Medical University, 209 Tongshan Road, Xuzhou 221004, China.; Center of Clinical Oncology, The Affiliated Hospital of Xuzhou Medical University, 99 West Huaihai Road, Xuzhou 221002, China.; Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Xuzhou Medical University, 209 Tongshan Road, Xuzhou 221004, China.
Chen Y; Cancer Institute, Xuzhou Medical University, 209 Tongshan Road, Xuzhou 221004, China.; Center of Clinical Oncology, The Affiliated Hospital of Xuzhou Medical University, 99 West Huaihai Road, Xuzhou 221002, China.; Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Xuzhou Medical University, 209 Tongshan Road, Xuzhou 221004, China.
Huang N; Cancer Institute, Xuzhou Medical University, 209 Tongshan Road, Xuzhou 221004, China.
Zhou X; Cancer Institute, Xuzhou Medical University, 209 Tongshan Road, Xuzhou 221004, China.; Department of Oncology, Suzhou Xiangcheng People's Hospital, Suzhou 215131, China.
Lv Y; Cancer Institute, Xuzhou Medical University, 209 Tongshan Road, Xuzhou 221004, China.
Li H; Cancer Institute, Xuzhou Medical University, 209 Tongshan Road, Xuzhou 221004, China.; Center of Clinical Oncology, The Affiliated Hospital of Xuzhou Medical University, 99 West Huaihai Road, Xuzhou 221002, China.; Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Xuzhou Medical University, 209 Tongshan Road, Xuzhou 221004, China.
Chai D; Cancer Institute, Xuzhou Medical University, 209 Tongshan Road, Xuzhou 221004, China.; Center of Clinical Oncology, The Affiliated Hospital of Xuzhou Medical University, 99 West Huaihai Road, Xuzhou 221002, China.; Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Xuzhou Medical University, 209 Tongshan Road, Xuzhou 221004, China.
Zheng J; Center of Clinical Oncology, The Affiliated Hospital of Xuzhou Medical University, 99 West Huaihai Road, Xuzhou 221002, China.; Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Xuzhou Medical University, 209 Tongshan Road, Xuzhou 221004, China.
Wang G; Cancer Institute, Xuzhou Medical University, 209 Tongshan Road, Xuzhou 221004, China.; Center of Clinical Oncology, The Affiliated Hospital of Xuzhou Medical University, 99 West Huaihai Road, Xuzhou 221002, China.; Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Xuzhou Medical University, 209 Tongshan Road, Xuzhou 221004, China.; Pokaż więcej
Źródło:: Cancer biology & medicine [Cancer Biol Med] 2024 Jan 02; Vol. 21 (2).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Benzodiazepines*
Lung Neoplasms*/genetics
Lung Neoplasms*/drug therapy
Animals ; Humans ; Mice ; Arachidonate 5-Lipoxygenase/therapeutic use ; Azulenes ; Cell Line, Tumor ; Lung ; Matrix Metalloproteinase 9/genetics ; Matrix Metalloproteinase 9/metabolism ; Matrix Metalloproteinase 9/therapeutic use ; Neoplasm Invasiveness ; Neoplastic Processes ; Neutrophils/metabolism ; Poly(ADP-ribose) Polymerase Inhibitors

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Skocz do pozycji: 4.

Tytuł:: ALOX5 acts as a key role in regulating the immune microenvironment in intrahepatic cholangiocarcinoma, recruiting tumor-associated macrophages through PI3K pathway.
Autorzy:: Chen J; Department of General Surgery, Xinhua Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200092, China.; Shanghai Key Laboratory of Biliary Tract Disease Research, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China.
Tang Y; Department of General Surgery, Xinhua Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200092, China.; Shanghai Key Laboratory of Biliary Tract Disease Research, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China.
Qin D; Department of General Surgery, Xinhua Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200092, China.; Shanghai Key Laboratory of Biliary Tract Disease Research, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China.
Yu X; Department of General Surgery, Xinhua Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200092, China.; Shanghai Key Laboratory of Biliary Tract Disease Research, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China.
Tong H; Department of General Surgery, Xinhua Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200092, China.; Shanghai Key Laboratory of Biliary Tract Disease Research, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China.
Tang C; Department of General Surgery, Xinhua Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200092, China.
Tang Z; Department of General Surgery, Xinhua Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200092, China. .; Department of Blood Transfusion, Xinhua Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200092, China. .; Shanghai Key Laboratory of Biliary Tract Disease Research, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China. .; Pokaż więcej
Źródło:: Journal of translational medicine [J Transl Med] 2023 Dec 20; Vol. 21 (1), pp. 923. Date of Electronic Publication: 2023 Dec 20.
Typ publikacji:: Journal Article
MeSH Terms:: Phosphatidylinositol 3-Kinases*
Cholangiocarcinoma*/genetics
Animals ; Mice ; Humans ; Tumor-Associated Macrophages ; Mice, Nude ; Leukotriene B4 ; Tumor Microenvironment ; Cell Line, Tumor ; Arachidonate 5-Lipoxygenase

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Skocz do pozycji: 5.

Tytuł:: 'Mechanistic insights into 5-lipoxygenase inhibition by active principles derived from essential oils of Curcuma species: Molecular docking, ADMET analysis and molecular dynamic simulation study.
Autorzy:: Gadnayak A; Centre for Biotechnology, Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India.
Dehury B; ICMR-Regional Medical Research Center, Nalco Square, Chandrasekharpur, Bhubaneswar, Odisha, India.
Nayak A; Centre for Biotechnology, Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India.
Jena S; Centre for Biotechnology, Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India.
Sahoo A; Centre for Biotechnology, Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India.
Panda PC; Centre for Biotechnology, Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India.
Ray A; Centre for Biotechnology, Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India.
Nayak S; Centre for Biotechnology, Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2022 Jul 22; Vol. 17 (7), pp. e0271956. Date of Electronic Publication: 2022 Jul 22 (Print Publication: 2022).
Typ publikacji:: Journal Article
MeSH Terms:: Arachidonate 5-Lipoxygenase*/metabolism
Oils, Volatile*/pharmacology
Oils, Volatile*/therapeutic use
Curcuma/chemistry ; Inflammation/drug therapy ; Ligands ; Lipoxygenase Inhibitors/pharmacology ; Molecular Docking Simulation ; Molecular Dynamics Simulation

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Skocz do pozycji: 6.

Tytuł:: Respiratory Syncytial Virus Nonstructural Protein 1 Promotes 5-Lipoxygenase via miR-19a-3p.
Autorzy:: Zheng M; Department of Pediatrics, Children's Digital Health and Data Center, Zhongnan Hospital of Wuhan University, Wuhan, China.
Fan P; Department of Pediatrics, Children's Digital Health and Data Center, Zhongnan Hospital of Wuhan University, Wuhan, China.
Yang P; Department of Pediatrics, Children's Digital Health and Data Center, Zhongnan Hospital of Wuhan University, Wuhan, China.
Zheng J; Department of Pediatrics, Children's Digital Health and Data Center, Zhongnan Hospital of Wuhan University, Wuhan, China.
Zhao D; Department of Pediatrics, Children's Digital Health and Data Center, Zhongnan Hospital of Wuhan University, Wuhan, China.; Pokaż więcej
Źródło:: Journal of immunology research [J Immunol Res] 2022 May 20; Vol. 2022, pp. 4086710. Date of Electronic Publication: 2022 May 20 (Print Publication: 2022).
Typ publikacji:: Journal Article
MeSH Terms:: Arachidonate 5-Lipoxygenase*/genetics
MicroRNAs*/genetics
Respiratory Syncytial Virus, Human*
Viral Nonstructural Proteins*/metabolism
Humans ; Interleukin-5 ; Respiratory Syncytial Virus Infections/genetics

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Skocz do pozycji: 7.

Tytuł:: In Vitro Evaluation and In Silico Calculations of the Antioxidant and Anti-Inflammatory Properties of Secondary Metabolites from Leonurus sibiricus L. Root Extracts.
Autorzy:: Merecz-Sadowska A; Department of Economic and Medical Informatics, University of Lodz, 90-214 Lodz, Poland.
Sitarek P; Department of Medical Biology, Medical University of Lodz, 90-151 Lodz, Poland.
Kowalczyk T; Department of Molecular Biotechnology and Genetics, Faculty of Biology and Environmental Protection, University of Lodz, 90-237 Lodz, Poland.
Palusiak M; Theoretical and Structural Group, Department of Physical Chemistry, Faculty of Chemistry, University of Lodz, 90-236 Lodz, Poland.
Hoelm M; Theoretical and Structural Group, Department of Physical Chemistry, Faculty of Chemistry, University of Lodz, 90-236 Lodz, Poland.
Zajdel K; Department of Medical Informatics and Statistics, Medical University of Lodz, 90-645 Lodz, Poland.
Zajdel R; Department of Economic and Medical Informatics, University of Lodz, 90-214 Lodz, Poland.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2023 Sep 10; Vol. 28 (18). Date of Electronic Publication: 2023 Sep 10.
Typ publikacji:: Journal Article
MeSH Terms:: Antioxidants*/pharmacology
Leonurus*
Humans ; Arachidonate 5-Lipoxygenase ; Cyclooxygenase 2 ; Hydrogen Peroxide ; Molecular Docking Simulation ; Xanthine Oxidase ; Flavonoids/pharmacology ; Rutin ; Anti-Inflammatory Agents/pharmacology ; Chlorogenic Acid ; Plant Extracts/pharmacology

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Skocz do pozycji: 8.

Tytuł:: Alveolar socket healing in 5-lipoxygenase knockout aged female mice treated or not with high dose of zoledronic acid.
Autorzy:: Mahmoud RH; Department of Basic Sciences, School of Dentistry, São Paulo State University (UNESP), Araçatuba, São Paulo, Brazil.
Biguetti CC; Department of Bioengineering, University of Texas at Dallas, Richardson, TX, USA.
Simionato GB; Department of Basic Sciences, School of Dentistry, São Paulo State University (UNESP), Araçatuba, São Paulo, Brazil.
Custódio IC; Department of Health Sciences, Centro Universitário Sagrado Coração, Bauru, São Paulo, Brazil.
Silva RBP; Department of Basic Sciences, School of Dentistry, São Paulo State University (UNESP), Araçatuba, São Paulo, Brazil.
Duarte MAH; Bauru School of Dentistry, University of São Paulo, FOB-USP, Bauru, São Paulo, Brazil.
Faverani LP; Department of Surgery, School of Dentistry, São Paulo State University (UNESP), Araçatuba, São Paulo, Brazil.
Ervolino E; Department of Basic Sciences, School of Dentistry, São Paulo State University (UNESP), Araçatuba, São Paulo, Brazil.
Fakhouri WD; Center for Craniofacial Research, University of Texas Health Science Center at Houston, School of Dentistry, Houston, TX, USA.
Matsumoto MA; Department of Basic Sciences, School of Dentistry, São Paulo State University (UNESP), Araçatuba, São Paulo, Brazil. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2021 Oct 01; Vol. 11 (1), pp. 19535. Date of Electronic Publication: 2021 Oct 01.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Arachidonate 5-Lipoxygenase/*deficiency
Tooth Socket/*drug effects
Wound Healing/*drug effects
Zoledronic Acid/*administration & dosage
Age Factors ; Animals ; Arachidonate 5-Lipoxygenase/genetics ; Biomarkers ; Disease Models, Animal ; Female ; Gene Expression ; Immunohistochemistry ; Mice ; Mice, Knockout ; Tooth Extraction/adverse effects ; Tooth Extraction/methods ; Tooth Socket/diagnostic imaging ; Tooth Socket/pathology ; Treatment Outcome ; X-Ray Microtomography

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Skocz do pozycji: 9.

Tytuł:: ALOX5-5-HETE promotes gastric cancer growth and alleviates chemotherapy toxicity via MEK/ERK activation.
Autorzy:: Tang J; Department of General Surgery, Xiangyang No.1 People's Hospital, Hubei University of Medicine, Xiangyang, China.
Zhang C; Department of Pediatrics, Xiangyang No.1 People's Hospital, Hubei University of Medicine, Xiangyang, China.
Lin J; Department of Blood Transfusion, Xiangyang Traditional Chinese Medicine Hospital, Xiangyang, China.
Duan P; Department of Obstetrics and Gynaecology, Xiangyang No.1 People's Hospital, Hubei University of Medicine, Xiangyang, China.
Long J; Department of Oncology, Jingzhou Central Hospital, The Second Clinical Medical College, Yangtze University, Jingzhou, China.
Zhu H; Department of Oncology, Xiangyang No.1 People's Hospital, Hubei University of Medicine, Xiangyang, China.; Pokaż więcej
Źródło:: Cancer medicine [Cancer Med] 2021 Aug; Vol. 10 (15), pp. 5246-5255. Date of Electronic Publication: 2021 Jun 13.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Cell Proliferation*
Arachidonate 5-Lipoxygenase/*metabolism
Hydroxyeicosatetraenoic Acids/*metabolism
MAP Kinase Signaling System/*physiology
Stomach Neoplasms/*metabolism
Analysis of Variance ; Antineoplastic Agents/adverse effects ; Antineoplastic Agents/therapeutic use ; Arachidonate 5-Lipoxygenase/drug effects ; Cell Survival ; Disease Progression ; Humans ; Hydroxyurea/analogs & derivatives ; Hydroxyurea/therapeutic use ; Lipoxygenase Inhibitors/therapeutic use ; MAP Kinase Signaling System/drug effects ; Phosphorylation ; Stomach Neoplasms/drug therapy ; Stomach Neoplasms/pathology ; Up-Regulation

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Skocz do pozycji: 10.

Tytuł:: Dual synergistic inhibition of COX and LOX by potential chemicals from Indian daily spices investigated through detailed computational studies.
Autorzy:: Rudrapal M; Department of Pharmaceutical Sciences, School of Biotechnology and Pharmaceutical Sciences, Vignan's Foundation for Science, Technology & Research (Deemed to Be University), Guntur, 522213, India. .
Eltayeb WA; Biotechnology Department, Faculty of Science and Technology, Shendi University, Shendi, 414601, Sudan.
Rakshit G; Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Ranchi, 835215, India.
El-Arabey AA; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Cairo, 11651, Egypt.
Khan J; Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Majmaah University, Al'Majmaah, 11952, Saudi Arabia. .; Health and Basic Sciences Research Center, Majmaah University, Al'Majmaah, 11952, Saudi Arabia. .
Aldosari SM; Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Majmaah University, Al'Majmaah, 11952, Saudi Arabia.; Health and Basic Sciences Research Center, Majmaah University, Al'Majmaah, 11952, Saudi Arabia.
Alshehri B; Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Majmaah University, Al'Majmaah, 11952, Saudi Arabia.; Health and Basic Sciences Research Center, Majmaah University, Al'Majmaah, 11952, Saudi Arabia.
Abdalla M; Pediatric Research Institute, Children's Hospital Affiliated to Shandong University, Jinan, 250022, People's Republic of China. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2023 May 27; Vol. 13 (1), pp. 8656. Date of Electronic Publication: 2023 May 27.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Curcumin*/pharmacology
Humans ; Molecular Docking Simulation ; Lipoxygenase ; Capsaicin/pharmacology ; Spices ; Lipoxygenase Inhibitors/pharmacology ; Lipoxygenase Inhibitors/chemistry ; Cyclooxygenase 2 ; Cyclooxygenase 2 Inhibitors ; Anti-Inflammatory Agents/pharmacology ; Inflammation ; Arachidonate 5-Lipoxygenase/chemistry

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Skocz do pozycji: 11.

Tytuł:: Paeonol prevents migration and invasion, and promotes apoptosis of cervical cancer cells by inhibiting 5‑lipoxygenase.
Autorzy:: Sheng SQ; Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Zhejiang Chinese Medicine University, Hangzhou, Zhejiang 310005, P.R. China.
Yu LY; Second Clinical Medical College, Zhejiang Chinese Medicine University, Hangzhou, Zhejiang 310005, P.R. China.
Zhou XW; Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Zhejiang Chinese Medicine University, Hangzhou, Zhejiang 310005, P.R. China.
Pan HY; Third Clinical Medical College, Zhejiang Chinese Medicine University, Hangzhou, Zhejiang 310005, P.R. China.
Hu FY; Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Zhejiang Chinese Medicine University, Hangzhou, Zhejiang 310005, P.R. China.
Liu JL; Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Zhejiang Chinese Medicine University, Hangzhou, Zhejiang 310005, P.R. China.; Pokaż więcej
Źródło:: Molecular medicine reports [Mol Med Rep] 2021 Jun; Vol. 23 (6). Date of Electronic Publication: 2021 Mar 31.
Typ publikacji:: Journal Article
MeSH Terms:: Acetophenones/*pharmacology
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Arachidonate 5-Lipoxygenase/*metabolism
Cell Movement/*drug effects
Arachidonate 5-Lipoxygenase/genetics ; Cell Proliferation/drug effects ; HeLa Cells ; Humans

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Skocz do pozycji: 12.

Tytuł:: Polyphenolic Profile of Callistemon viminalis Aerial Parts: Antioxidant, Anticancer and In Silico 5-LOX Inhibitory Evaluations.
Autorzy:: Mahgoub S; Biochemistry and Molecular Biology Department, Faculty of Pharmacy, Helwan University, Ein-Helwan, Helwan, Cairo 11795, Egypt.
Hashad N; Department of Pharmacognosy, Faculty of Pharmacy, Helwan University, Ein Helwan, Cairo 11795, Egypt.
Ali S; Biochemistry and Molecular Biology Department, Faculty of Pharmacy, Helwan University, Ein-Helwan, Helwan, Cairo 11795, Egypt.
Ibrahim R; Department of Pharmacognosy, Faculty of Pharmacy, Helwan University, Ein Helwan, Cairo 11795, Egypt.
Said AM; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Helwan University, Ein-Helwan, Helwan, Cairo 11795, Egypt.; Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA.
Moharram FA; Department of Pharmacognosy, Faculty of Pharmacy, Helwan University, Ein Helwan, Cairo 11795, Egypt.
Mady M; Department of Pharmacognosy, Faculty of Pharmacy, Helwan University, Ein Helwan, Cairo 11795, Egypt.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2021 Apr 24; Vol. 26 (9). Date of Electronic Publication: 2021 Apr 24.
Typ publikacji:: Journal Article
MeSH Terms:: Antineoplastic Agents/*pharmacology
Antioxidants/*chemistry
Arachidonate 5-Lipoxygenase/*drug effects
Myrtaceae/*chemistry
Antineoplastic Agents/chemistry ; Antioxidants/pharmacology ; Arachidonate 5-Lipoxygenase/genetics ; Humans ; MCF-7 Cells ; Oxidative Stress/drug effects ; Plant Components, Aerial/chemistry ; Polyphenols/chemistry ; Polyphenols/pharmacology

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Skocz do pozycji: 13.

Tytuł:: Modulation of the 5-Lipoxygenase Pathway by Chalcogen-Containing Inhibitors of Leukotriene A 4 Hydrolase.
Autorzy:: Teder T; Division of Physiological Chemistry II, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 17177 Stockholm, Sweden.
König S; Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Greifswald University, 17489 Greifswald, Germany.
Singh R; Division of Physiological Chemistry II, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 17177 Stockholm, Sweden.
Samuelsson B; Division of Physiological Chemistry II, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 17177 Stockholm, Sweden.
Werz O; Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich Schiller University Jena, 7743 Jena, Germany.
Garscha U; Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Greifswald University, 17489 Greifswald, Germany.
Haeggström JZ; Division of Physiological Chemistry II, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 17177 Stockholm, Sweden.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Apr 19; Vol. 24 (8). Date of Electronic Publication: 2023 Apr 19.
Typ publikacji:: Journal Article
MeSH Terms:: Epoxide Hydrolases*/metabolism
Chalcogens*
Leukotriene A4 ; Arachidonate 5-Lipoxygenase ; Aminopeptidases/metabolism

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Skocz do pozycji: 14.

Tytuł:: Extraction and preparation of 5-lipoxygenase and acetylcholinesterase inhibitors from Astragalus membranaceus stems and leaves.
Autorzy:: Liu R; College of Chemistry, Central Laboratory, Changchun Normal University, Changchun, P. R. China.
Zhang Y; College of Chemistry, Central Laboratory, Changchun Normal University, Changchun, P. R. China.
Li S; College of Chemistry, Central Laboratory, Changchun Normal University, Changchun, P. R. China.
Liu C; College of Chemistry, Central Laboratory, Changchun Normal University, Changchun, P. R. China.
Zhuang S; College of Chemistry, Central Laboratory, Changchun Normal University, Changchun, P. R. China.
Zhou X; College of Chemistry, Central Laboratory, Changchun Normal University, Changchun, P. R. China.
Li Y; College of Chemistry, Central Laboratory, Changchun Normal University, Changchun, P. R. China.
Zhang Y; College of Chemistry, Central Laboratory, Changchun Normal University, Changchun, P. R. China.
Liang J; College of Chemistry, Central Laboratory, Changchun Normal University, Changchun, P. R. China.; Pokaż więcej
Źródło:: Journal of separation science [J Sep Sci] 2023 Feb; Vol. 46 (4), pp. e2200812. Date of Electronic Publication: 2023 Jan 11.
Typ publikacji:: Journal Article
MeSH Terms:: Astragalus propinquus*/chemistry
Acetylcholinesterase*
Cholinesterase Inhibitors ; Arachidonate 5-Lipoxygenase ; Molecular Docking Simulation ; Chromatography, High Pressure Liquid/methods ; Countercurrent Distribution/methods

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Skocz do pozycji: 15.

Tytuł:: Aberrant ALOX5 Activation Correlates with HER2 Status and Mediates Breast Cancer Biological Activities through Multiple Mechanisms.
Autorzy:: Zhou X; Department of Breast Surgery, Guangxi Medical University Cancer Hospital, Nanning, Guangxi 530021, China.
Jiang Y; Department of Breast Surgery, Guangxi Medical University Cancer Hospital, Nanning, Guangxi 530021, China.
Li Q; Department of Breast Surgery, Guangxi Medical University Cancer Hospital, Nanning, Guangxi 530021, China.
Huang Z; Department of Breast Surgery, Guangxi Medical University Cancer Hospital, Nanning, Guangxi 530021, China.
Yang H; Department of Breast Surgery, Guangxi Medical University Cancer Hospital, Nanning, Guangxi 530021, China.
Wei C; Department of Breast Surgery, Guangxi Medical University Cancer Hospital, Nanning, Guangxi 530021, China.; Pokaż więcej
Źródło:: BioMed research international [Biomed Res Int] 2020 Nov 10; Vol. 2020, pp. 1703531. Date of Electronic Publication: 2020 Nov 10 (Print Publication: 2020).
Typ publikacji:: Journal Article
MeSH Terms:: Arachidonate 5-Lipoxygenase/*metabolism
Breast Neoplasms/*pathology
Receptor, ErbB-2/*metabolism
Arachidonate 5-Lipoxygenase/genetics ; Breast Neoplasms/metabolism ; Cell Line, Tumor ; Epithelial-Mesenchymal Transition ; Female ; Humans ; MCF-7 Cells ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; RNA, Small Interfering ; Receptor, ErbB-2/genetics ; Signal Transduction ; TOR Serine-Threonine Kinases/metabolism ; Up-Regulation ; rhoA GTP-Binding Protein/metabolism

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Skocz do pozycji: 16.

Tytuł:: Dual COX and 5-LOX inhibition by clerodane diterpenes from seeds of Polyalthia longifolia (Sonn.) Thwaites.
Autorzy:: Nguyen HT; Institute of Research and Development, Duy Tan University, Da Nang, 550000, Vietnam.; Faculty of Medicine, Duy Tan University, Da Nang, 550000, Vietnam.
Vu TY; Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, 700000, Vietnam.
Chandi V; Pharmacology Department, AU College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, Andhra Pradesh, 530003, India.
Polimati H; Pharmacology Department, AU College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, Andhra Pradesh, 530003, India.; Pharmacology and Toxicology Division, Incozen Therapeutics Pvt Ltd., Turkapally, Telangana, 500078, India.
Tatipamula VB; Institute of Research and Development, Duy Tan University, Da Nang, 550000, Vietnam. .; Faculty of Medicine, Duy Tan University, Da Nang, 550000, Vietnam. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2020 Sep 29; Vol. 10 (1), pp. 15965. Date of Electronic Publication: 2020 Sep 29.
Typ publikacji:: Journal Article
MeSH Terms:: Arachidonate 5-Lipoxygenase/*metabolism
Cyclooxygenase 1/*metabolism
Cyclooxygenase 2/*metabolism
Diterpenes, Clerodane/*pharmacology
Polyalthia/*chemistry
Arachidonate 5-Lipoxygenase/chemistry ; Computer Simulation ; Cyclooxygenase 1/chemistry ; Cyclooxygenase 2/chemistry ; Cyclooxygenase Inhibitors/chemistry ; Cyclooxygenase Inhibitors/pharmacology ; Diterpenes, Clerodane/chemistry ; Humans ; Lipoxygenase Inhibitors/chemistry ; Lipoxygenase Inhibitors/pharmacology ; Models, Molecular ; Molecular Docking Simulation ; Molecular Structure ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Seeds/chemistry

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Skocz do pozycji: 17.

Tytuł:: Exploring Biological Activity of 4-Oxo-4 H -furo[2,3- h ]chromene Derivatives as Potential Multi-Target-Directed Ligands Inhibiting Cholinesterases, β-Secretase, Cyclooxygenase-2, and Lipoxygenase-5/15.
Autorzy:: Mphahlele MJ; Department of Chemistry, College of Science, Engineering and Technology, University of South Africa, Private Bag X06, Florida 1710, South Africa.
Agbo EN; Department of Chemistry, College of Science, Engineering and Technology, University of South Africa, Private Bag X06, Florida 1710, South Africa.
Gildenhuys S; Department of Life & Consumer Sciences, College of Agriculture and Environmental Sciences, University of South Africa, Private Bag X06, Florida 1710, South Africa.
Setshedi IB; Department of Life & Consumer Sciences, College of Agriculture and Environmental Sciences, University of South Africa, Private Bag X06, Florida 1710, South Africa.; Pokaż więcej
Źródło:: Biomolecules [Biomolecules] 2019 Nov 13; Vol. 9 (11). Date of Electronic Publication: 2019 Nov 13.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Amyloid Precursor Protein Secretases*/antagonists & inhibitors
Amyloid Precursor Protein Secretases*/chemistry
Amyloid Precursor Protein Secretases*/metabolism
Arachidonate 5-Lipoxygenase*/chemistry
Arachidonate 5-Lipoxygenase*/metabolism
Cholinesterase Inhibitors*/chemistry
Cholinesterase Inhibitors*/pharmacology
Cholinesterases*/chemistry
Cholinesterases*/metabolism
Cyclooxygenase 2*/chemistry
Cyclooxygenase 2*/metabolism
Cyclooxygenase 2 Inhibitors*/chemistry
Lipoxygenase Inhibitors*/chemistry
Lipoxygenase Inhibitors*/pharmacology
HEK293 Cells ; Humans ; Ligands ; MCF-7 Cells ; Molecular Docking Simulation

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Skocz do pozycji: 18.

Tytuł:: Iron Dyshomeostasis in COVID-19: Biomarkers Reveal a Functional Link to 5-Lipoxygenase Activation.
Autorzy:: Dufrusine B; Department of Bioscience and Technology for Food Agriculture and Environment, University of Teramo, 64100 Teramo, Italy.; Department of Innovative Technologies in Medicine and Dentistry, University 'G. d'Annunzio' of Chieti-Pescara, 66100 Chieti, Italy.; Center for Advanced Studies and Technology (CAST), University 'G. d'Annunzio' of Chieti-Pescara, 66100 Chieti, Italy.
Valentinuzzi S; Center for Advanced Studies and Technology (CAST), University 'G. d'Annunzio' of Chieti-Pescara, 66100 Chieti, Italy.; Department of Pharmacy, University 'G. d'Annunzio' of Chieti-Pescara, 66100 Chieti, Italy.
Bibbò S; Department of Innovative Technologies in Medicine and Dentistry, University 'G. d'Annunzio' of Chieti-Pescara, 66100 Chieti, Italy.; Center for Advanced Studies and Technology (CAST), University 'G. d'Annunzio' of Chieti-Pescara, 66100 Chieti, Italy.
Damiani V; Department of Innovative Technologies in Medicine and Dentistry, University 'G. d'Annunzio' of Chieti-Pescara, 66100 Chieti, Italy.; Center for Advanced Studies and Technology (CAST), University 'G. d'Annunzio' of Chieti-Pescara, 66100 Chieti, Italy.
Lanuti P; Center for Advanced Studies and Technology (CAST), University 'G. d'Annunzio' of Chieti-Pescara, 66100 Chieti, Italy.; Department of Medicine and Aging Science, 'G. d'Annunzio' University of Chieti-Pescara, 66100 Chieti, Italy.
Pieragostino D; Department of Innovative Technologies in Medicine and Dentistry, University 'G. d'Annunzio' of Chieti-Pescara, 66100 Chieti, Italy.; Center for Advanced Studies and Technology (CAST), University 'G. d'Annunzio' of Chieti-Pescara, 66100 Chieti, Italy.
Del Boccio P; Center for Advanced Studies and Technology (CAST), University 'G. d'Annunzio' of Chieti-Pescara, 66100 Chieti, Italy.; Department of Pharmacy, University 'G. d'Annunzio' of Chieti-Pescara, 66100 Chieti, Italy.
D'Alessandro E; Center for Advanced Studies and Technology (CAST), University 'G. d'Annunzio' of Chieti-Pescara, 66100 Chieti, Italy.
Rabottini A; Center for Advanced Studies and Technology (CAST), University 'G. d'Annunzio' of Chieti-Pescara, 66100 Chieti, Italy.
Berghella A; Department of Bioscience and Technology for Food Agriculture and Environment, University of Teramo, 64100 Teramo, Italy.
Allocati N; Department of Innovative Technologies in Medicine and Dentistry, University 'G. d'Annunzio' of Chieti-Pescara, 66100 Chieti, Italy.
Falasca K; Department of Medicine and Aging Science, 'G. d'Annunzio' University of Chieti-Pescara, 66100 Chieti, Italy.; Clinic of Infectious Diseases, S.S. Annunziata Hospital, 66100 Chieti, Italy.
Ucciferri C; Clinic of Infectious Diseases, S.S. Annunziata Hospital, 66100 Chieti, Italy.
Mucedola F; Clinic of Infectious Diseases, S.S. Annunziata Hospital, 66100 Chieti, Italy.
Di Perna M; Pneumology Department, 'SS Annunziata' Hospital, 66100 Chieti, Italy.
Martino L; Pneumology Department, 'SS Annunziata' Hospital, 66100 Chieti, Italy.
Vecchiet J; Department of Medicine and Aging Science, 'G. d'Annunzio' University of Chieti-Pescara, 66100 Chieti, Italy.; Clinic of Infectious Diseases, S.S. Annunziata Hospital, 66100 Chieti, Italy.
De Laurenzi V; Department of Innovative Technologies in Medicine and Dentistry, University 'G. d'Annunzio' of Chieti-Pescara, 66100 Chieti, Italy.; Center for Advanced Studies and Technology (CAST), University 'G. d'Annunzio' of Chieti-Pescara, 66100 Chieti, Italy.
Dainese E; Department of Bioscience and Technology for Food Agriculture and Environment, University of Teramo, 64100 Teramo, Italy.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2022 Dec 20; Vol. 24 (1). Date of Electronic Publication: 2022 Dec 20.
Typ publikacji:: Journal Article
MeSH Terms:: Iron*/metabolism
COVID-19*
Humans ; Lipocalin-2 ; Post-Acute COVID-19 Syndrome ; Arachidonate 5-Lipoxygenase/metabolism ; Proteomics ; Biomarkers

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Skocz do pozycji: 19.

Tytuł:: TiO 2 nanotube immobilised 5-lipoxygenase-mediated screening and isolation of anti-inflammatory active compounds from the leaves of lonicera japonica thunb.
Autorzy:: Zhu J; Henan International Joint Laboratory of Medicinal Plants Utilization, College of Chemistry and Chemical Engineering, Henan University, Kaifeng, China.
Zhou D; Henan International Joint Laboratory of Medicinal Plants Utilization, College of Chemistry and Chemical Engineering, Henan University, Kaifeng, China.
Wu D; Henan International Joint Laboratory of Medicinal Plants Utilization, College of Chemistry and Chemical Engineering, Henan University, Kaifeng, China.
Liu W; Henan International Joint Laboratory of Medicinal Plants Utilization, College of Chemistry and Chemical Engineering, Henan University, Kaifeng, China.
Liu X; Henan International Joint Laboratory of Medicinal Plants Utilization, College of Chemistry and Chemical Engineering, Henan University, Kaifeng, China.; Pokaż więcej
Źródło:: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2022 Dec; Vol. 37 (1), pp. 2540-2550.
Typ publikacji:: Journal Article
MeSH Terms:: Lonicera*/chemistry
Nanotubes*
Animals ; Anti-Inflammatory Agents/pharmacology ; Arachidonate 5-Lipoxygenase ; Luteolin ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Rats ; Titanium

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Skocz do pozycji: 20.

Tytuł:: Pharmacological and genetic targeting of 5-lipoxygenase interrupts c-Myc oncogenic signaling and kills enzalutamide-resistant prostate cancer cells via apoptosis.
Autorzy:: Monga J; Vattikuti Urology Institute, Henry Ford Health System, Detroit, MI, 48202, United States.
Subramani D; Vattikuti Urology Institute, Henry Ford Health System, Detroit, MI, 48202, United States.
Bharathan A; Vattikuti Urology Institute, Henry Ford Health System, Detroit, MI, 48202, United States.
Ghosh J; Vattikuti Urology Institute, Henry Ford Health System, Detroit, MI, 48202, United States. .; Henry Ford Cancer Institute, Henry Ford Health System, Detroit, MI, 48202, United States. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2020 Apr 20; Vol. 10 (1), pp. 6649. Date of Electronic Publication: 2020 Apr 20.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Gene Expression Regulation, Neoplastic*
5-Lipoxygenase-Activating Protein Inhibitors/*pharmacology
Antineoplastic Agents/*pharmacology
Arachidonate 5-Lipoxygenase/*genetics
Indoles/*pharmacology
Phenylthiohydantoin/*analogs & derivatives
Proto-Oncogene Proteins c-myc/*genetics
Quinolines/*pharmacology
Apoptosis/drug effects ; Apoptosis/genetics ; Arachidonate 5-Lipoxygenase/metabolism ; Benzamides ; Cell Line ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Drug Resistance, Neoplasm/drug effects ; Drug Resistance, Neoplasm/genetics ; Fibroblasts/cytology ; Fibroblasts/drug effects ; Fibroblasts/metabolism ; Humans ; Male ; Nitriles ; Organ Specificity ; Phenylthiohydantoin/pharmacology ; Prostate/metabolism ; Prostate/pathology ; Proto-Oncogene Proteins c-myc/metabolism ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Signal Transduction

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