Temat: "Arachidonate 5-Lipoxygenase" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Utility of novel 2-furanones in synthesis of other heterocyclic compounds having anti-inflammatory activity with dual COX2/LOX inhibition.
Autorzy:: Abd El-Hameed RH; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Helwan University, Cairo, Egypt.
Mahgoub S; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Helwan University, Cairo, Egypt.
El-Shanbaky HM; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Helwan University, Cairo, Egypt.
Mohamed MS; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Helwan University, Cairo, Egypt.
Ali SA; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Helwan University, Cairo, Egypt.; Pokaż więcej
Źródło:: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 977-986.
Typ publikacji:: Journal Article
MeSH Terms:: 4-Butyrolactone/*analogs & derivatives
Anti-Inflammatory Agents, Non-Steroidal/*pharmacology
Cyclooxygenase 2 Inhibitors/*pharmacology
Heterocyclic Compounds/*pharmacology
Lipoxygenase Inhibitors/*pharmacology
4-Butyrolactone/chemical synthesis ; 4-Butyrolactone/chemistry ; 4-Butyrolactone/pharmacology ; Anti-Inflammatory Agents, Non-Steroidal/chemical synthesis ; Anti-Inflammatory Agents, Non-Steroidal/chemistry ; Arachidonate 5-Lipoxygenase/metabolism ; Cyclooxygenase 2/metabolism ; Cyclooxygenase 2 Inhibitors/chemical synthesis ; Cyclooxygenase 2 Inhibitors/chemistry ; Dose-Response Relationship, Drug ; Heterocyclic Compounds/chemical synthesis ; Heterocyclic Compounds/chemistry ; Humans ; Lipoxygenase Inhibitors/chemical synthesis ; Lipoxygenase Inhibitors/chemistry ; Molecular Structure ; Structure-Activity Relationship ; Tumor Necrosis Factor-alpha/antagonists & inhibitors

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Skocz do pozycji: 2.

Tytuł:: Exploring Biological Activity of 4-Oxo-4 H -furo[2,3- h ]chromene Derivatives as Potential Multi-Target-Directed Ligands Inhibiting Cholinesterases, β-Secretase, Cyclooxygenase-2, and Lipoxygenase-5/15.
Autorzy:: Mphahlele MJ; Department of Chemistry, College of Science, Engineering and Technology, University of South Africa, Private Bag X06, Florida 1710, South Africa.
Agbo EN; Department of Chemistry, College of Science, Engineering and Technology, University of South Africa, Private Bag X06, Florida 1710, South Africa.
Gildenhuys S; Department of Life & Consumer Sciences, College of Agriculture and Environmental Sciences, University of South Africa, Private Bag X06, Florida 1710, South Africa.
Setshedi IB; Department of Life & Consumer Sciences, College of Agriculture and Environmental Sciences, University of South Africa, Private Bag X06, Florida 1710, South Africa.; Pokaż więcej
Źródło:: Biomolecules [Biomolecules] 2019 Nov 13; Vol. 9 (11). Date of Electronic Publication: 2019 Nov 13.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Amyloid Precursor Protein Secretases*/antagonists & inhibitors
Amyloid Precursor Protein Secretases*/chemistry
Amyloid Precursor Protein Secretases*/metabolism
Arachidonate 5-Lipoxygenase*/chemistry
Arachidonate 5-Lipoxygenase*/metabolism
Cholinesterase Inhibitors*/chemistry
Cholinesterase Inhibitors*/pharmacology
Cholinesterases*/chemistry
Cholinesterases*/metabolism
Cyclooxygenase 2*/chemistry
Cyclooxygenase 2*/metabolism
Cyclooxygenase 2 Inhibitors*/chemistry
Lipoxygenase Inhibitors*/chemistry
Lipoxygenase Inhibitors*/pharmacology
HEK293 Cells ; Humans ; Ligands ; MCF-7 Cells ; Molecular Docking Simulation

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Skocz do pozycji: 3.

Tytuł:: Dihydroisocoumarins, Naphthalenes, and Further Polyketides from Aloe vera and A. plicatilis : Isolation, Identification and Their 5-LOX/COX-1 Inhibiting Potency.
Autorzy:: Rauwald HW; Department of Pharmaceutical Biology, Leipzig University, Johannisallee 21-23, 04103 Leipzig, Germany.
Maucher R; Department of Pharmaceutical Biology, Leipzig University, Johannisallee 21-23, 04103 Leipzig, Germany.
Dannhardt G; Department of Pharmaceutical and Medicinal Chemistry, Johannes Gutenberg-University, 55122 Mainz, Germany.
Kuchta K; Department of Pharmaceutical Biology, Leipzig University, Johannisallee 21-23, 04103 Leipzig, Germany.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2021 Jul 12; Vol. 26 (14). Date of Electronic Publication: 2021 Jul 12.
Typ publikacji:: Journal Article
MeSH Terms:: Aloe/*chemistry
Coumarins/*chemistry
Cyclooxygenase 1/*metabolism
Cyclooxygenase Inhibitors/*chemistry
Lipoxygenase Inhibitors/*chemistry
Naphthalenes/*chemistry
Polyketides/*chemistry
Anthraquinones/chemistry ; Anthraquinones/pharmacology ; Anti-Inflammatory Agents ; Arachidonate 5-Lipoxygenase/metabolism ; Chromones/chemistry ; Chromones/pharmacology ; Coumarins/pharmacology ; Cyclooxygenase Inhibitors/pharmacology ; Glucosides/chemistry ; Glucosides/pharmacology ; Lipoxygenase Inhibitors/pharmacology ; Naphthalenes/pharmacology ; Phenols/chemistry ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Polyketides/pharmacology

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Skocz do pozycji: 4.

Tytuł:: Sinapic acid phenethyl ester as a potent selective 5-lipoxygenase inhibitor: Synthesis and structure-activity relationship.
Autorzy:: Touaibia M; Department of Chemistry and Biochemistry, Université de Moncton, Moncton, NB, Canada.
Hébert MJG; Department of Chemistry and Biochemistry, Université de Moncton, Moncton, NB, Canada.
Levesque NA; Department of Chemistry and Biochemistry, Université de Moncton, Moncton, NB, Canada.
Doiron JA; Department of Chemistry and Biochemistry, Université de Moncton, Moncton, NB, Canada.
Doucet MS; Department of Chemistry and Biochemistry, Université de Moncton, Moncton, NB, Canada.
Jean-François J; Department of Chemistry and Biochemistry, Université de Moncton, Moncton, NB, Canada.
Cormier M; Department of Chemistry and Biochemistry, Université de Moncton, Moncton, NB, Canada.
Boudreau LH; Department of Chemistry and Biochemistry, Université de Moncton, Moncton, NB, Canada.
Surette ME; Department of Chemistry and Biochemistry, Université de Moncton, Moncton, NB, Canada.; Pokaż więcej
Źródło:: Chemical biology & drug design [Chem Biol Drug Des] 2018 Nov; Vol. 92 (5), pp. 1876-1887. Date of Electronic Publication: 2018 Jul 18.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Arachidonate 5-Lipoxygenase/*chemistry
Coumaric Acids/*chemistry
Esters/*chemistry
Lipoxygenase Inhibitors/*chemical synthesis
Arachidonate 5-Lipoxygenase/metabolism ; Binding Sites ; Cyclooxygenase 1/biosynthesis ; Esters/chemical synthesis ; Esters/metabolism ; Free Radical Scavengers/chemistry ; HEK293 Cells ; Humans ; Leukocytes, Mononuclear/cytology ; Leukocytes, Mononuclear/drug effects ; Leukocytes, Mononuclear/metabolism ; Lipoxygenase Inhibitors/chemistry ; Lipoxygenase Inhibitors/metabolism ; Molecular Docking Simulation ; Protein Structure, Tertiary ; Structure-Activity Relationship

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Skocz do pozycji: 5.

Tytuł:: Lipoxygenase Inhibition by Plant Extracts.
Autorzy:: Lončarić M; Faculty of Food Technology Osijek, Josip Juraj Strossmayer University of Osijek, Franje Kuhaca 18, 31000 Osijek, Croatia.
Strelec I; Faculty of Food Technology Osijek, Josip Juraj Strossmayer University of Osijek, Franje Kuhaca 18, 31000 Osijek, Croatia.
Moslavac T; Faculty of Food Technology Osijek, Josip Juraj Strossmayer University of Osijek, Franje Kuhaca 18, 31000 Osijek, Croatia.
Šubarić D; Faculty of Food Technology Osijek, Josip Juraj Strossmayer University of Osijek, Franje Kuhaca 18, 31000 Osijek, Croatia.
Pavić V; Department of Biology, Josip Juraj Strossmayer University of Osijek, Ulica cara Hadrijana 8/A, 31000 Osijek, Croatia.
Molnar M; Faculty of Food Technology Osijek, Josip Juraj Strossmayer University of Osijek, Franje Kuhaca 18, 31000 Osijek, Croatia.; Pokaż więcej
Źródło:: Biomolecules [Biomolecules] 2021 Jan 25; Vol. 11 (2). Date of Electronic Publication: 2021 Jan 25.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:: Fatty Acids, Unsaturated/*chemistry
Inflammation/*drug therapy
Lipoxygenase Inhibitors/*pharmacology
Oxygen/*chemistry
Plant Extracts/*pharmacology
Animals ; Arachidonate 15-Lipoxygenase/biosynthesis ; Arachidonate 5-Lipoxygenase/biosynthesis ; Arachidonic Acid ; Fatty Acids ; Flowers/enzymology ; Humans ; Hydrogen Peroxide/chemistry ; Inhibitory Concentration 50 ; Lipoxygenase/metabolism ; Lipoxygenase Inhibitors/chemistry ; Oxidation-Reduction ; Plant Leaves/enzymology ; Polyphenols/chemistry

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Skocz do pozycji: 6.

Tytuł:: Synthesis and structure-activity relationships of novel 5-(hydroxamic acid)methyl oxazolidinone derivatives as 5-lipoxygenase inhibitors.
Autorzy:: Phillips OA; Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Kuwait University, Safat, Kuwait.
Bosso MA; Faculty of Medicine, Department of Pharmacology & Toxicology, Kuwait University, Safat, Kuwait.
Ezeamuzie CI; Faculty of Medicine, Department of Pharmacology & Toxicology, Kuwait University, Safat, Kuwait.; Pokaż więcej
Źródło:: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2020 Dec; Vol. 35 (1), pp. 1471-1482.
Typ publikacji:: Journal Article
MeSH Terms:: Anti-Inflammatory Agents, Non-Steroidal/*pharmacology
Arachidonate 5-Lipoxygenase/*metabolism
Hydroxamic Acids/*pharmacology
Inflammation/*drug therapy
Lipoxygenase Inhibitors/*pharmacology
Oxazolidinones/*pharmacology
Animals ; Anti-Inflammatory Agents, Non-Steroidal/chemical synthesis ; Anti-Inflammatory Agents, Non-Steroidal/chemistry ; Cell Line ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Female ; Humans ; Hydroxamic Acids/chemical synthesis ; Hydroxamic Acids/chemistry ; Inflammation/chemically induced ; Inflammation/metabolism ; Leukotriene B4/antagonists & inhibitors ; Leukotriene B4/biosynthesis ; Lipoxygenase Inhibitors/chemical synthesis ; Lipoxygenase Inhibitors/chemistry ; Male ; Mice ; Mice, Inbred BALB C ; Molecular Structure ; Oxazolidinones/chemical synthesis ; Oxazolidinones/chemistry ; Structure-Activity Relationship ; Zymosan

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Skocz do pozycji: 7.

Tytuł:: New Zileuton-Hydroxycinnamic Acid Hybrids: Synthesis and Structure-Activity Relationship towards 5-Lipoxygenase Inhibition.
Autorzy:: Chiasson AI; Department of Chemistry and Biochemistry, Université de Moncton, Moncton, NB E1A3E9, Canada.
Robichaud S; Department of Chemistry and Biochemistry, Université de Moncton, Moncton, NB E1A3E9, Canada.
Ndongou Moutombi FJ; Department of Chemistry and Biochemistry, Université de Moncton, Moncton, NB E1A3E9, Canada.
Hébert MPA; Department of Chemistry and Biochemistry, Université de Moncton, Moncton, NB E1A3E9, Canada.
Mbarik M; Department of Chemistry and Biochemistry, Université de Moncton, Moncton, NB E1A3E9, Canada.
Surette ME; Department of Chemistry and Biochemistry, Université de Moncton, Moncton, NB E1A3E9, Canada.
Touaibia M; Department of Chemistry and Biochemistry, Université de Moncton, Moncton, NB E1A3E9, Canada.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2020 Oct 14; Vol. 25 (20). Date of Electronic Publication: 2020 Oct 14.
Typ publikacji:: Journal Article
MeSH Terms:: Coumaric Acids/*chemistry
Hydroxyurea/*analogs & derivatives
Lipoxygenase Inhibitors/*chemistry
Lipoxygenase Inhibitors/*pharmacology
Arachidonate 5-Lipoxygenase/chemistry ; Arachidonate 5-Lipoxygenase/metabolism ; Computer Simulation ; Drug Evaluation, Preclinical ; Free Radical Scavengers/chemistry ; Free Radical Scavengers/pharmacology ; HEK293 Cells ; Humans ; Hydroxyurea/chemistry ; Lipoxygenase Inhibitors/chemical synthesis ; Molecular Docking Simulation ; Neutrophils/drug effects ; Neutrophils/metabolism ; Structure-Activity Relationship

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Skocz do pozycji: 8.

Tytuł:: Extraction, Antioxidant Capacity, 5-Lipoxygenase Inhibition, and Phytochemical Composition of Propolis from Eastern Canada.
Autorzy:: Sambou M; Department of Chemistry and Biochemistry, Université de Moncton, Moncton, NB E1A 3E9, Canada.
Jean-François J; Department of Chemistry, Texas Lutheran University, Seguin, TX 78155, USA.
Ndongou Moutombi FJ; Department of Chemistry and Biochemistry, Université de Moncton, Moncton, NB E1A 3E9, Canada.
Doiron JA; Department of Chemistry and Biochemistry, Université de Moncton, Moncton, NB E1A 3E9, Canada.
Hébert MPA; Department of Chemistry and Biochemistry, Université de Moncton, Moncton, NB E1A 3E9, Canada.
Joy AP; Atlantic Cancer Research Institute, Moncton, NB E1C 8X3, Canada.
Mai-Thi NN; Atlantic Cancer Research Institute, Moncton, NB E1C 8X3, Canada.
Barnett DA; Atlantic Cancer Research Institute, Moncton, NB E1C 8X3, Canada.
Surette ME; Department of Chemistry and Biochemistry, Université de Moncton, Moncton, NB E1A 3E9, Canada.
Boudreau LH; Department of Chemistry and Biochemistry, Université de Moncton, Moncton, NB E1A 3E9, Canada.
Touaibia M; Department of Chemistry and Biochemistry, Université de Moncton, Moncton, NB E1A 3E9, Canada.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2020 May 21; Vol. 25 (10). Date of Electronic Publication: 2020 May 21.
Typ publikacji:: Journal Article
MeSH Terms:: Antioxidants/*chemistry
Biological Products/*chemistry
Lipoxygenase Inhibitors/*chemistry
Propolis/*chemistry
Antioxidants/isolation & purification ; Antioxidants/pharmacology ; Arachidonate 5-Lipoxygenase/chemistry ; Biological Products/classification ; Biological Products/isolation & purification ; HEK293 Cells ; Humans ; Lipoxygenase Inhibitors/isolation & purification ; Lipoxygenase Inhibitors/pharmacology ; Phenols/chemistry ; Phytochemicals/chemistry ; Phytochemicals/pharmacology ; Propolis/pharmacology

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Skocz do pozycji: 9.

Tytuł:: Antioxidant drimane-type sesquiterpenoid from muricid gastropod Chicoreus ramosus attenuates pro-inflammatory 5-lipoxygenase and carbolytic enzymes.
Autorzy:: Chakraborty K; Marine Biotechnology Division, Central Marine Fisheries Research Institute, Cochin, India.
Salas S; Marine Biotechnology Division, Central Marine Fisheries Research Institute, Cochin, India.; Pokaż więcej
Źródło:: Journal of food biochemistry [J Food Biochem] 2019 Nov; Vol. 43 (11), pp. e12991. Date of Electronic Publication: 2019 Jul 30.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Anti-Inflammatory Agents/*pharmacology
Antioxidants/*pharmacology
Gastropoda/*chemistry
Lipoxygenase Inhibitors/*pharmacology
Polycyclic Sesquiterpenes/*pharmacology
Sesquiterpenes/*pharmacology
Animals ; Anti-Inflammatory Agents/chemistry ; Antioxidants/chemistry ; Arachidonate 5-Lipoxygenase/metabolism ; Lipoxygenase Inhibitors/chemistry ; Polycyclic Sesquiterpenes/chemistry ; Sesquiterpenes/chemistry

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Skocz do pozycji: 10.

Tytuł:: Treatment with either COX-2 inhibitor or 5-LOX inhibitor causes no compensation between COX-2 pathway and 5-LOX pathway in chronic aluminum overload-induced liver injury in rats.
Autorzy:: Xia H; Department of Pharmacology, Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing Medical University, Chongqing, 400016, China.
He Q; Department of Hepatobiliary Surgery, First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Wang H; Department of Pharmacology, Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing Medical University, Chongqing, 400016, China.
Wang Y; Department of Neonatalogy, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China.
Yang Y; Department of Pharmacology, Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing Medical University, Chongqing, 400016, China.
Li Y; Department of Pharmacology, Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing Medical University, Chongqing, 400016, China.
Zhang J; Department of Pharmacology, Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing Medical University, Chongqing, 400016, China.
Chen Z; Department of Pharmacology, Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing Medical University, Chongqing, 400016, China.
Yang J; Department of Pharmacology, Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing Medical University, Chongqing, 400016, China.; Pokaż więcej
Źródło:: Fundamental & clinical pharmacology [Fundam Clin Pharmacol] 2019 Oct; Vol. 33 (5), pp. 535-543. Date of Electronic Publication: 2019 Apr 02.
Typ publikacji:: Journal Article
MeSH Terms:: Aluminum/*pharmacology
Arachidonate 5-Lipoxygenase/*metabolism
Chemical and Drug Induced Liver Injury, Chronic/*drug therapy
Cyclooxygenase 2/*metabolism
Cyclooxygenase 2 Inhibitors/*pharmacology
Lipoxygenase Inhibitors/*pharmacology
Animals ; Caffeic Acids/pharmacology ; Chemical and Drug Induced Liver Injury, Chronic/metabolism ; Inflammation/drug therapy ; Inflammation/metabolism ; Liver/drug effects ; Liver/metabolism ; Malondialdehyde/metabolism ; Oxidative Stress/drug effects ; Rats ; Rats, Sprague-Dawley

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Skocz do pozycji: 11.

Tytuł:: Phenolic acid phenethylesters and their corresponding ketones: Inhibition of 5-lipoxygenase and stability in human blood and HepaRG cells.
Autorzy:: Mbarik M; Department of Chemistry and Biochemistry Université de Moncton Moncton NB Canada.
Poirier SJ; Department of Chemistry and Biochemistry Université de Moncton Moncton NB Canada.
Doiron J; Department of Chemistry and Biochemistry Université de Moncton Moncton NB Canada.
Selka A; Department of Chemistry and Biochemistry Université de Moncton Moncton NB Canada.
Barnett DA; Atlantic Cancer Research Institute Moncton NB Canada.
Cormier M; Department of Chemistry and Biochemistry Université de Moncton Moncton NB Canada.
Touaibia M; Department of Chemistry and Biochemistry Université de Moncton Moncton NB Canada.
Surette ME; Department of Chemistry and Biochemistry Université de Moncton Moncton NB Canada.; Pokaż więcej
Źródło:: Pharmacology research & perspectives [Pharmacol Res Perspect] 2019 Sep 13; Vol. 7 (5), pp. e00524. Date of Electronic Publication: 2019 Sep 13 (Print Publication: 2019).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Arachidonate 5-Lipoxygenase/*metabolism
Hydroxybenzoates/*chemical synthesis
Ketones/*chemical synthesis
Lipoxygenase Inhibitors/*chemical synthesis
Blood Chemical Analysis ; Caffeic Acids/chemistry ; Cell Line ; Drug Stability ; Esters/chemistry ; HEK293 Cells ; Humans ; Hydroxybenzoates/chemistry ; Hydroxybenzoates/pharmacology ; Inhibitory Concentration 50 ; Ketones/chemistry ; Ketones/pharmacology ; Lipoxygenase Inhibitors/chemistry ; Lipoxygenase Inhibitors/pharmacology ; Molecular Docking Simulation ; Neutrophils/chemistry ; Phenylethyl Alcohol/analogs & derivatives ; Phenylethyl Alcohol/chemistry

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Skocz do pozycji: 12.

Tytuł:: Phenolic Profiling and Biological Potential of Ficus curtipes Corner Leaves and Stem Bark: 5-Lipoxygenase Inhibition and Interference with NO Levels in LPS-Stimulated RAW 264.7 Macrophages.
Autorzy:: Andrade C; REQUIMTE/LAQV, Laboratório de Farmacognosia, Departamento de Química, Faculdade de Farmácia, Universidade do Porto, R. Jorge Viterbo Ferreira, n° 228, 4050-313 Porto, Portugal.
Ferreres F; Research Group on Quality, Safety and Bioactivity of Plant Foods, Department of Food Science and Technology, CEBAS (CSIC), P.O. Box 164, 30100 Murcia, Spain. .
Gomes NGM; REQUIMTE/LAQV, Laboratório de Farmacognosia, Departamento de Química, Faculdade de Farmácia, Universidade do Porto, R. Jorge Viterbo Ferreira, n° 228, 4050-313 Porto, Portugal.
Duangsrisai S; Department of Botany, Faculty of Science, Kasetsart University, Ngam Wong Wan Road, Chatuchak, Bangkok 10900, Thailand.; Center for Advanced Studies in Tropical Natural Resources, NRU-KU, Kasetsart University, Chatuchak, Bangkok 10900, Thailand.
Srisombat N; Department of Botany, Faculty of Science, Kasetsart University, Ngam Wong Wan Road, Chatuchak, Bangkok 10900, Thailand.; Center for Advanced Studies in Tropical Natural Resources, NRU-KU, Kasetsart University, Chatuchak, Bangkok 10900, Thailand.
Vajrodaya S; Department of Botany, Faculty of Science, Kasetsart University, Ngam Wong Wan Road, Chatuchak, Bangkok 10900, Thailand.; Center for Advanced Studies in Tropical Natural Resources, NRU-KU, Kasetsart University, Chatuchak, Bangkok 10900, Thailand.
Pereira DM; REQUIMTE/LAQV, Laboratório de Farmacognosia, Departamento de Química, Faculdade de Farmácia, Universidade do Porto, R. Jorge Viterbo Ferreira, n° 228, 4050-313 Porto, Portugal.
Gil-Izquierdo A; Research Group on Quality, Safety and Bioactivity of Plant Foods, Department of Food Science and Technology, CEBAS (CSIC), P.O. Box 164, 30100 Murcia, Spain.
Andrade PB; REQUIMTE/LAQV, Laboratório de Farmacognosia, Departamento de Química, Faculdade de Farmácia, Universidade do Porto, R. Jorge Viterbo Ferreira, n° 228, 4050-313 Porto, Portugal.
Valentão P; REQUIMTE/LAQV, Laboratório de Farmacognosia, Departamento de Química, Faculdade de Farmácia, Universidade do Porto, R. Jorge Viterbo Ferreira, n° 228, 4050-313 Porto, Portugal. .; Pokaż więcej
Źródło:: Biomolecules [Biomolecules] 2019 Aug 22; Vol. 9 (9). Date of Electronic Publication: 2019 Aug 22.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Ficus/*chemistry
Lipopolysaccharides/*pharmacology
Lipoxygenase Inhibitors/*pharmacology
Macrophages/*drug effects
Nitric Oxide/*metabolism
Phenols/*pharmacology
Plant Bark/*chemistry
Animals ; Arachidonate 5-Lipoxygenase/metabolism ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Lipoxygenase Inhibitors/isolation & purification ; Macrophages/cytology ; Macrophages/metabolism ; Mice ; Phenols/isolation & purification ; RAW 264.7 Cells

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Skocz do pozycji: 13.

Tytuł:: Molecular modelling insights into a physiologically favourable approach to eicosanoid biosynthesis inhibition through novel thieno[2,3-b]pyridine derivatives.
Autorzy:: Mohamed MS; a Department of Pharmaceutical Organic Chemistry , Faculty of Pharmacy, Helwan University , Cairo , Egypt.
Mansour YE; a Department of Pharmaceutical Organic Chemistry , Faculty of Pharmacy, Helwan University , Cairo , Egypt.
Amin HK; b Department of Biochemistry and Molecular Biology , Faculty of Pharmacy, Helwan University , Cairo , Egypt.
El-Araby ME; a Department of Pharmaceutical Organic Chemistry , Faculty of Pharmacy, Helwan University , Cairo , Egypt.; Pokaż więcej
Źródło:: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2018 Dec; Vol. 33 (1), pp. 755-767.
Typ publikacji:: Journal Article
MeSH Terms:: Anti-Inflammatory Agents, Non-Steroidal/*pharmacology
Cyclooxygenase Inhibitors/*pharmacology
Edema/*drug therapy
Eicosanoids/*antagonists & inhibitors
Lipoxygenase Inhibitors/*pharmacology
Pyridines/*pharmacology
Animals ; Anti-Inflammatory Agents, Non-Steroidal/chemical synthesis ; Anti-Inflammatory Agents, Non-Steroidal/chemistry ; Arachidonate 5-Lipoxygenase/metabolism ; Cyclooxygenase Inhibitors/chemical synthesis ; Cyclooxygenase Inhibitors/chemistry ; Dose-Response Relationship, Drug ; Eicosanoids/biosynthesis ; Eicosanoids/chemistry ; Lipoxygenase Inhibitors/chemical synthesis ; Lipoxygenase Inhibitors/chemistry ; Male ; Models, Molecular ; Molecular Structure ; Prostaglandin-Endoperoxide Synthases/metabolism ; Pyridines/chemical synthesis ; Pyridines/chemistry ; Rats ; Rats, Sprague-Dawley ; Structure-Activity Relationship

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Skocz do pozycji: 14.

Tytuł:: Enzymatic Studies of Isoflavonoids as Selective and Potent Inhibitors of Human Leukocyte 5-Lipo-Oxygenase.
Autorzy:: Mascayano C; Departamento de Ciencias del Ambiente, Facultad de Química y Biología, Universidad de Santiago, Chile, Casilla 442, Correo 2, Santiago, Chile.
Espinosa V; Laboratorio de Investigación Científica Emory Black, Escuela de Medicina, Facultad de Ciencias Médicas, Universidad de Santiago, Chile, Casilla 442, Correo 2, Santiago, Chile.
Sepúlveda-Boza S; Laboratorio de Investigación Científica Emory Black, Escuela de Medicina, Facultad de Ciencias Médicas, Universidad de Santiago, Chile, Casilla 442, Correo 2, Santiago, Chile.
Hoobler EK; Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA, 95064.
Perry S; Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA, 95064.
Diaz G; Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA, 95064.
Holman TR; Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA, 95064.; Pokaż więcej
Źródło:: Chemical biology & drug design [Chem Biol Drug Des] 2015 Jul; Vol. 86 (1), pp. 114-21. Date of Electronic Publication: 2014 Nov 28.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:: Arachidonate 5-Lipoxygenase*/chemistry
Arachidonate 5-Lipoxygenase*/metabolism
Flavonoids*/chemical synthesis
Flavonoids*/chemistry
Flavonoids*/pharmacology
Lipoxygenase Inhibitors*/chemical synthesis
Lipoxygenase Inhibitors*/chemistry
Lipoxygenase Inhibitors*/pharmacology
Molecular Dynamics Simulation*
Leukocytes/*enzymology
Animals ; Humans ; Sheep

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Skocz do pozycji: 15.

Tytuł:: 5-Lipoxygenase inhibitors attenuate TNF-α-induced inflammation in human synovial fibroblasts.
Autorzy:: Lin HC; Department of Pharmacology, College of Medicine, National Taiwan University and Hospital, Taipei, Taiwan.
Lin TH; Department of Pharmacology, College of Medicine, National Taiwan University and Hospital, Taipei, Taiwan.
Wu MY; Department of Pharmacology, College of Medicine, National Taiwan University and Hospital, Taipei, Taiwan.
Chiu YC; Department of Orthopaedics, Taichung Veterans General Hospital, Taichung, Taiwan.
Tang CH; Department of Pharmacology, College of Medicine, China Medical University, Taichung, Taiwan.
Hour MJ; School of Pharmacy, College of Medicine, China Medical University, Taichung, Taiwan.
Liou HC; Department of Pharmacology, College of Medicine, National Taiwan University and Hospital, Taipei, Taiwan.
Tu HJ; Department of Pharmacology, College of Medicine, National Taiwan University and Hospital, Taipei, Taiwan.
Yang RS; Department of Orthopedics, College of Medicine, National Taiwan University and Hospital, Taipei, Taiwan.
Fu WM; Department of Pharmacology, College of Medicine, National Taiwan University and Hospital, Taipei, Taiwan.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2014 Sep 17; Vol. 9 (9), pp. e107890. Date of Electronic Publication: 2014 Sep 17 (Print Publication: 2014).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Arachidonate 5-Lipoxygenase/*metabolism
Fibroblasts/*drug effects
Lipoxygenase Inhibitors/*pharmacology
Synovial Membrane/*pathology
Tumor Necrosis Factor-alpha/*adverse effects
Animals ; Arachidonate 5-Lipoxygenase/deficiency ; Arachidonate 5-Lipoxygenase/genetics ; Chemokine CCL2/blood ; Chemokine CCL2/genetics ; Chemokine CCL2/metabolism ; Edema/drug therapy ; Edema/genetics ; Edema/metabolism ; Edema/pathology ; Enzyme Activation/drug effects ; Fibroblasts/metabolism ; Gene Knockout Techniques ; Humans ; I-kappa B Kinase/metabolism ; Inflammation/chemically induced ; Inflammation/drug therapy ; Inflammation/metabolism ; Inflammation/pathology ; Interleukin-6/genetics ; Interleukin-6/metabolism ; Leukotriene B4/metabolism ; Lipoxygenase Inhibitors/therapeutic use ; Male ; Mice ; Mice, Inbred C57BL ; Phosphorylation/drug effects ; Proteolysis/drug effects ; RNA Interference ; RNA, Small Interfering/genetics

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Tytuł:: Identification of 1, 4-Dihydrothieno [3', 2':5, 6]thiopyrano[4, 3-c] pyrazole derivatives as human 5-Lipo-oxygenase inhibitors.
Autorzy:: Hu J; Beijing National Laboratory for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China.
Zhu W
Meng H
Liu Y
Wang X
Hu C; Pokaż więcej
Źródło:: Chemical biology & drug design [Chem Biol Drug Des] 2014 Dec; Vol. 84 (6), pp. 642-7. Date of Electronic Publication: 2014 Jun 21.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Arachidonate 5-Lipoxygenase/*chemistry
Heterocyclic Compounds, 3-Ring/*chemistry
Lipoxygenase Inhibitors/*chemistry
Piperazines/*chemistry
Pyrazoles/*chemistry
Arachidonate 5-Lipoxygenase/metabolism ; Binding Sites ; Heterocyclic Compounds, 3-Ring/chemical synthesis ; Heterocyclic Compounds, 3-Ring/metabolism ; Humans ; Inhibitory Concentration 50 ; Lipoxygenase Inhibitors/metabolism ; Molecular Docking Simulation ; Piperazines/chemical synthesis ; Piperazines/metabolism ; Protein Structure, Tertiary ; Pyrazoles/chemical synthesis ; Pyrazoles/metabolism ; Structure-Activity Relationship

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Tytuł:: Triterpene Acids from Frankincense and Semi-Synthetic Derivatives That Inhibit 5-Lipoxygenase and Cathepsin G.
Autorzy:: Koeberle A; Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich-Schiller-University, Philosophenweg 14, D-07743 Jena, Germany. .
Henkel A; Department of Pharmaceutical Analytics, Pharmaceutical Institute, Eberhard Karls University, Auf der Morgenstelle 8, D-72076 Tuebingen, Germany. .
Verhoff M; Department of Pharmaceutical Analytics, Pharmaceutical Institute, Eberhard Karls University, Auf der Morgenstelle 8, D-72076 Tuebingen, Germany. .
Tausch L; Institute of Pharmaceutical Chemistry, University of Frankfurt, Max-von-Laue-Str. 9, D-60438 Frankfurt, Germany. .
König S; Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich-Schiller-University, Philosophenweg 14, D-07743 Jena, Germany. .
Fischer D; Department of Pharmaceutical Technology, Institute of Pharmacy, Friedrich-Schiller-University, Otto-Schott-Strasse 41, D-07745 Jena, Germany. .
Kather N; Organic Chemistry II, Saarland University, Campus C4.2, D-66123 Saarbruecken, Germany. .
Seitz S; Organic Chemistry II, Saarland University, Campus C4.2, D-66123 Saarbruecken, Germany. .
Paul M; Organic Chemistry II, Saarland University, Campus C4.2, D-66123 Saarbruecken, Germany. .
Jauch J; Organic Chemistry II, Saarland University, Campus C4.2, D-66123 Saarbruecken, Germany. .
Werz O; Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich-Schiller-University, Philosophenweg 14, D-07743 Jena, Germany. .; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2018 Feb 24; Vol. 23 (2). Date of Electronic Publication: 2018 Feb 24.
Typ publikacji:: Journal Article
MeSH Terms:: Cathepsin G/*antagonists & inhibitors
Frankincense/*chemistry
Lipoxygenase Inhibitors/*chemistry
Lipoxygenase Inhibitors/*pharmacology
Plant Extracts/*chemistry
Plant Extracts/*pharmacology
Triterpenes/*chemistry
Triterpenes/*pharmacology
Arachidonate 5-Lipoxygenase/metabolism ; Enzyme Activation/drug effects ; Lipoxygenase Inhibitors/chemical synthesis ; Lipoxygenase Inhibitors/isolation & purification ; Plant Extracts/isolation & purification ; Triterpenes/chemical synthesis ; Triterpenes/isolation & purification

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Tytuł:: New Hydroxycinnamic Acid Esters as Novel 5-Lipoxygenase Inhibitors That Affect Leukotriene Biosynthesis.
Autorzy:: Boudreau LH; Department of Chemistry and Biochemistry, Université de Moncton, Moncton, NB, Canada E1A 3E9.
Lassalle-Claux G; Department of Chemistry and Biochemistry, Université de Moncton, Moncton, NB, Canada E1A 3E9.
Cormier M; Department of Chemistry and Biochemistry, Université de Moncton, Moncton, NB, Canada E1A 3E9.
Blanchard S; Department of Chemistry and Biochemistry, Université de Moncton, Moncton, NB, Canada E1A 3E9.
Doucet MS; Department of Chemistry and Biochemistry, Université de Moncton, Moncton, NB, Canada E1A 3E9.
Surette ME; Department of Chemistry and Biochemistry, Université de Moncton, Moncton, NB, Canada E1A 3E9.
Touaibia M; Department of Chemistry and Biochemistry, Université de Moncton, Moncton, NB, Canada E1A 3E9.; Pokaż więcej
Źródło:: Mediators of inflammation [Mediators Inflamm] 2017; Vol. 2017, pp. 6904634. Date of Electronic Publication: 2017 Jun 07.
Typ publikacji:: Journal Article
MeSH Terms:: Arachidonate 5-Lipoxygenase/*metabolism
Caffeic Acids/*chemistry
Coumaric Acids/*chemistry
Leukotrienes/*biosynthesis
Lipoxygenase Inhibitors/*chemistry
Phenylethyl Alcohol/*analogs & derivatives
Caffeic Acids/pharmacology ; Enzyme Activation/drug effects ; Hydroxyurea/analogs & derivatives ; Hydroxyurea/chemistry ; Hydroxyurea/pharmacology ; Lipoxygenase Inhibitors/pharmacology ; Phenylethyl Alcohol/chemistry ; Phenylethyl Alcohol/pharmacology ; Structure-Activity Relationship

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Tytuł:: Design, Synthesis and Cellular Characterization of a Dual Inhibitor of 5-Lipoxygenase and Soluble Epoxide Hydrolase.
Autorzy:: Meirer K; Institute of Pharmaceutical Chemistry, Goethe-University of Frankfurt, Max-von-Laue Str. 9, D-60438 Frankfurt am Main, Germany. .
Glatzel D; Institute of Pharmaceutical Biology, Goethe-University of Frankfurt, Max-von-Laue Str. 9, D-60438 Frankfurt am Main, Germany. .
Kretschmer S; Institute of Pharmaceutical Chemistry, Goethe-University of Frankfurt, Max-von-Laue Str. 9, D-60438 Frankfurt am Main, Germany. .
Wittmann SK; Institute of Pharmaceutical Chemistry, Goethe-University of Frankfurt, Max-von-Laue Str. 9, D-60438 Frankfurt am Main, Germany. .
Hartmann M; Institute of Pharmaceutical Chemistry, Goethe-University of Frankfurt, Max-von-Laue Str. 9, D-60438 Frankfurt am Main, Germany. .
Blöcher R; Institute of Pharmaceutical Chemistry, Goethe-University of Frankfurt, Max-von-Laue Str. 9, D-60438 Frankfurt am Main, Germany. .
Angioni C; Institute of Clinical Pharmacology, Goethe-University of Frankfurt, Theodor-Stern-Kai 7, D-60590 Frankfurt am Main, Germany. .
Geisslinger G; Institute of Clinical Pharmacology, Goethe-University of Frankfurt, Theodor-Stern-Kai 7, D-60590 Frankfurt am Main, Germany. .
Steinhilber D; Institute of Pharmaceutical Chemistry, Goethe-University of Frankfurt, Max-von-Laue Str. 9, D-60438 Frankfurt am Main, Germany. .
Hofmann B; Institute of Pharmaceutical Chemistry, Goethe-University of Frankfurt, Max-von-Laue Str. 9, D-60438 Frankfurt am Main, Germany. .
Fürst R; Institute of Pharmaceutical Biology, Goethe-University of Frankfurt, Max-von-Laue Str. 9, D-60438 Frankfurt am Main, Germany. .
Proschak E; Institute of Pharmaceutical Chemistry, Goethe-University of Frankfurt, Max-von-Laue Str. 9, D-60438 Frankfurt am Main, Germany. .; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2016 Dec 29; Vol. 22 (1). Date of Electronic Publication: 2016 Dec 29.
Typ publikacji:: Journal Article
MeSH Terms:: Anti-Inflammatory Agents/*pharmacology
Arachidonate 5-Lipoxygenase/*metabolism
Arachidonic Acid/*metabolism
Epoxide Hydrolases/*antagonists & inhibitors
Hydrocarbons, Fluorinated/*pharmacology
Lipoxygenase Inhibitors/*chemical synthesis
Lipoxygenase Inhibitors/*pharmacology
Urea/*analogs & derivatives
Cell Adhesion/drug effects ; Cell Line, Tumor ; Human Umbilical Vein Endothelial Cells/metabolism ; Humans ; Hydrocarbons, Fluorinated/chemical synthesis ; Hydrocarbons, Fluorinated/chemistry ; Inflammation/drug therapy ; Leukocytes/metabolism ; Leukotrienes/biosynthesis ; Lipopolysaccharides ; Lipoxygenase Inhibitors/chemistry ; Urea/chemical synthesis ; Urea/chemistry ; Urea/pharmacology

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Tytuł:: 5-Lipoxygenase inhibitor zileuton inhibits Ca(2+)-responses induced by glutoxim and molixan in macrophages.
Autorzy:: Krutetskaya ZI; St. Petersburg State University, Universitetskaya nab. 7/9, St. Petersburg, 199034, Russia. .
Milenina LS; St. Petersburg State University, Universitetskaya nab. 7/9, St. Petersburg, 199034, Russia.
Naumova AA; St. Petersburg State University, Universitetskaya nab. 7/9, St. Petersburg, 199034, Russia.
Antonov VG; St. Petersburg State University, Universitetskaya nab. 7/9, St. Petersburg, 199034, Russia.
Nozdrachev AD; St. Petersburg State University, Universitetskaya nab. 7/9, St. Petersburg, 199034, Russia.; Pokaż więcej
Źródło:: Doklady. Biochemistry and biophysics [Dokl Biochem Biophys] 2016 Jul; Vol. 469 (1), pp. 302-4. Date of Electronic Publication: 2016 Sep 07.
Typ publikacji:: Journal Article
MeSH Terms:: Anti-Asthmatic Agents/*pharmacology
Hydroxyurea/*analogs & derivatives
Inosine/*pharmacology
Lipoxygenase Inhibitors/*pharmacology
Macrophages, Peritoneal/*drug effects
Oligopeptides/*pharmacology
Animals ; Arachidonate 5-Lipoxygenase/metabolism ; Calcium/metabolism ; Calcium Signaling/drug effects ; Calcium Signaling/physiology ; Cations, Divalent/metabolism ; Cells, Cultured ; Cytophotometry ; Drug Combinations ; Drug Interactions ; Fura-2/analogs & derivatives ; Hydroxyurea/pharmacology ; Intracellular Space/drug effects ; Intracellular Space/enzymology ; Macrophages, Peritoneal/enzymology ; Microscopy, Fluorescence ; Rats, Wistar

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