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Podgląd okładki
Tytuł :
Abnormal n-6 fatty acid metabolism in cystic fibrosis contributes to pulmonary symptoms.
Autorzy :
Wheelock CE; Division of Physiological Chemistry 2, Dept of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Strandvik B; Dept of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden. Electronic address: .
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Źródło :
Prostaglandins, leukotrienes, and essential fatty acids [Prostaglandins Leukot Essent Fatty Acids] 2020 Sep; Vol. 160, pp. 102156. Date of Electronic Publication: 2020 Jun 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Arachidonic Acid/*metabolism
Cystic Fibrosis/*metabolism
Cystic Fibrosis Transmembrane Conductance Regulator/*metabolism
Docosahexaenoic Acids/*deficiency
Linoleic Acid/*deficiency
Arachidonic Acid/deficiency ; Cystic Fibrosis/physiopathology ; Humans ; Inflammation/metabolism ; Linoleic Acid/metabolism ; Lipid Metabolism ; Lung/metabolism ; Lung/microbiology ; Lung/physiopathology ; Mucus/metabolism
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Genetic variants in FADS1 and ELOVL2 increase level of arachidonic acid and the risk of Alzheimer's disease in the Tunisian population.
Autorzy :
Hammouda S; Biochemistry Laboratory, LR12ES05 LR-NAFS 'Nutrition - Functional Food & Health' Faculty of Medicine Monastir, Tunisia.
Ghzaiel I; Biochemistry Laboratory, LR12ES05 LR-NAFS 'Nutrition - Functional Food & Health' Faculty of Medicine Monastir, Tunisia.
Khamlaoui W; Biochemistry Laboratory, LR12ES05 LR-NAFS 'Nutrition - Functional Food & Health' Faculty of Medicine Monastir, Tunisia.
Hammami S; Biochemistry Laboratory, LR12ES05 LR-NAFS 'Nutrition - Functional Food & Health' Faculty of Medicine Monastir, Tunisia; Department of Internal Medicine Bourguiba Monastir, Geriatric unit, Monastir Tunisia.
Mhenni SY; Department of Internal Medicine, Tahar Sfar Hospital, Mahdia. Tunisia.
Samet S; Department of neurology, Regional hospital of Kairouan. Tunisia.
Hammami M; Biochemistry Laboratory, LR12ES05 LR-NAFS 'Nutrition - Functional Food & Health' Faculty of Medicine Monastir, Tunisia.
Zarrouk A; Biochemistry Laboratory, LR12ES05 LR-NAFS 'Nutrition - Functional Food & Health' Faculty of Medicine Monastir, Tunisia; Biochemistry Laboratory, Faculty of Medicine Sousse. Tunisia. Electronic address: .
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Źródło :
Prostaglandins, leukotrienes, and essential fatty acids [Prostaglandins Leukot Essent Fatty Acids] 2020 Sep; Vol. 160, pp. 102159. Date of Electronic Publication: 2020 Jul 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alzheimer Disease/*genetics
Arachidonic Acid/*blood
Fatty Acid Desaturases/*genetics
Fatty Acid Elongases/*genetics
Fatty Acids, Unsaturated/*blood
8,11,14-Eicosatrienoic Acid/analysis ; 8,11,14-Eicosatrienoic Acid/blood ; Alleles ; Alzheimer Disease/blood ; Alzheimer Disease/physiopathology ; Arachidonic Acid/analysis ; Case-Control Studies ; Chromatography, Gas ; Docosahexaenoic Acids/analysis ; Docosahexaenoic Acids/blood ; Erythrocytes/metabolism ; Fatty Acids, Unsaturated/analysis ; Genotype ; Humans ; Linoleic Acid/analysis ; Polymorphism, Single Nucleotide ; Regression Analysis ; Risk Factors ; Tunisia/epidemiology ; gamma-Linolenic Acid/analysis
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Dietary Polyphenols Inhibit the Cytochrome P450 Monooxygenase Branch of the Arachidonic Acid Cascade with Remarkable Structure-Dependent Selectivity and Potency.
Autorzy :
Kampschulte N; Chair of Food Chemistry, Faculty of Mathematics and Natural Sciences, University of Wuppertal, Gaussstr. 20, 42119 Wuppertal, Germany.
Alasmer A; Chair of Food Chemistry, Faculty of Mathematics and Natural Sciences, University of Wuppertal, Gaussstr. 20, 42119 Wuppertal, Germany.
Empl MT; Institute for Food Toxicology, University of Veterinary Medicine Hannover, Bischofsholer Damm 15, 30173 Hannover, Germany.
Krohn M; Chair of Food Chemistry, Faculty of Mathematics and Natural Sciences, University of Wuppertal, Gaussstr. 20, 42119 Wuppertal, Germany.
Steinberg P; Institute for Food Toxicology, University of Veterinary Medicine Hannover, Bischofsholer Damm 15, 30173 Hannover, Germany.
Schebb NH; Chair of Food Chemistry, Faculty of Mathematics and Natural Sciences, University of Wuppertal, Gaussstr. 20, 42119 Wuppertal, Germany.; Institute for Food Toxicology, University of Veterinary Medicine Hannover, Bischofsholer Damm 15, 30173 Hannover, Germany.
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Źródło :
Journal of agricultural and food chemistry [J Agric Food Chem] 2020 Aug 26; Vol. 68 (34), pp. 9235-9244. Date of Electronic Publication: 2020 Aug 14.
Typ publikacji :
Journal Article
MeSH Terms :
Arachidonic Acid/*metabolism
Cytochrome P-450 Enzyme Inhibitors/*chemistry
Cytochrome P-450 Enzyme System/*metabolism
Polyphenols/*chemistry
Arachidonic Acid/chemistry ; Cytochrome P-450 Enzyme Inhibitors/metabolism ; Cytochrome P-450 Enzyme System/chemistry ; Humans ; Microsomes, Liver/chemistry ; Microsomes, Liver/enzymology ; Microsomes, Liver/metabolism ; Oxylipins/chemistry ; Oxylipins/metabolism ; Polyphenols/metabolism
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids.
Autorzy :
Koundouros N; Signalling and Cancer Metabolism Team, Division of Cancer Biology, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK; Division of Systems Medicine, Department of Metabolism Digestion and Reproduction, Imperial College London, London SW7 2AZ, UK.
Karali E; Signalling and Cancer Metabolism Team, Division of Cancer Biology, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK.
Tripp A; Signalling and Cancer Metabolism Team, Division of Cancer Biology, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK.
Valle A; Signalling and Cancer Metabolism Team, Division of Cancer Biology, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK; Energy Metabolism and Nutrition, Research Institute of Health Sciences (IUNICS), University of Balearic Islands, 07122 Palma de Mallorca, Spain; Health Research Institute of the Balearic Islands (IdISBa), University of Balearic Islands, 07120 Palma de Mallorca, Spain; Biomedical Research Networking Center for Physiopathology of Obesity and Nutrition (CIBERobn CB06/03/0043), Instituto de Salud Carlos III, 28029 Madrid, Spain.
Inglese P; Division of Systems Medicine, Department of Metabolism Digestion and Reproduction, Imperial College London, London SW7 2AZ, UK.
Perry NJS; Signalling and Cancer Metabolism Team, Division of Cancer Biology, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK.
Magee DJ; Signalling and Cancer Metabolism Team, Division of Cancer Biology, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK; Pain Medicine Department, The Royal Marsden Hospital, London, UK.
Anjomani Virmouni S; Signalling and Cancer Metabolism Team, Division of Cancer Biology, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK; Department of Life Sciences, College of Health and Life Sciences, Brunel University London, Uxbridge UB8 3PH, UK.
Elder GA; Signalling and Cancer Metabolism Team, Division of Cancer Biology, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK; School of Biological and Chemical Sciences, Queen Mary University of London, London E1 4NS, UK.
Tyson AL; Flow Cytometry and Light Microscopy Core Facility, Division of Cancer Biology, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK; Sainsbury Wellcome Centre for Neural Circuits and Behaviour, University College London, 25 Howland Street, London W1T 4JG, UK.
Dória ML; Division of Systems Medicine, Department of Metabolism Digestion and Reproduction, Imperial College London, London SW7 2AZ, UK.
van Weverwijk A; Breast Cancer Now Research Centre, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK; Division of Tumor Biology and Immunology, the Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands.
Soares RF; Division of Systems Medicine, Department of Metabolism Digestion and Reproduction, Imperial College London, London SW7 2AZ, UK.
Isacke CM; Breast Cancer Now Research Centre, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK.
Nicholson JK; Division of Systems Medicine, Department of Metabolism Digestion and Reproduction, Imperial College London, London SW7 2AZ, UK; The Australian National Phenome Centre, Health Futures Institute, Murdoch University, Perth WA6150, WA, Australia.
Glen RC; Division of Systems Medicine, Department of Metabolism Digestion and Reproduction, Imperial College London, London SW7 2AZ, UK; Centre for Molecular Informatics, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.
Takats Z; Division of Systems Medicine, Department of Metabolism Digestion and Reproduction, Imperial College London, London SW7 2AZ, UK. Electronic address: .
Poulogiannis G; Signalling and Cancer Metabolism Team, Division of Cancer Biology, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK; Division of Systems Medicine, Department of Metabolism Digestion and Reproduction, Imperial College London, London SW7 2AZ, UK. Electronic address: .
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Źródło :
Cell [Cell] 2020 Jun 25; Vol. 181 (7), pp. 1596-1611.e27. Date of Electronic Publication: 2020 Jun 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Arachidonic Acid/*analysis
Class I Phosphatidylinositol 3-Kinases/*metabolism
Eicosanoids/*metabolism
Animals ; Arachidonic Acid/metabolism ; Cell Line, Tumor ; Class I Phosphatidylinositol 3-Kinases/genetics ; Cytosol/metabolism ; Eicosanoids/physiology ; Enzyme Activation ; Female ; Humans ; Lipid Metabolism/physiology ; Mechanistic Target of Rapamycin Complex 2/metabolism ; Metabolic Networks and Pathways/genetics ; Metabolic Networks and Pathways/physiology ; Mice, Inbred BALB C ; Mice, Nude ; Phosphatidylinositol 3-Kinases/metabolism ; Phospholipases A2/metabolism ; Phosphorylation ; Protein Kinase C/metabolism ; Signal Transduction ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Systematic genome analysis of a novel arachidonic acid-producing strain uncovered unique metabolic traits in the production of acetyl-CoA-derived products in Mortierellale fungi.
Autorzy :
Vorapreeda T; Biochemical Engineering and Systems Biology Research Group, National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), at King Mongkut's University of Technology Thonburi, Bangkhuntien, Bangkok 10150, Thailand.
Thammarongtham C; Biochemical Engineering and Systems Biology Research Group, National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), at King Mongkut's University of Technology Thonburi, Bangkhuntien, Bangkok 10150, Thailand.
Palasak T; Functional Ingredients and Food Innovation Research Group, National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), Thailand Science Park, Pathum Thani 12120, Thailand.
Srisuk T; Pilot Plant Development and Training Institute, King Mongkut's University of Technology Thonburi Bangkhuntien, Bangkok 10150, Thailand.
Jenjaroenpun P; Department of Biomedical Informatics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Wongsurawat T; Department of Biomedical Informatics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Nookaew I; Department of Biomedical Informatics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Laoteng K; Functional Ingredients and Food Innovation Research Group, National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), Thailand Science Park, Pathum Thani 12120, Thailand. Electronic address: .
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Źródło :
Gene [Gene] 2020 May 30; Vol. 741, pp. 144559. Date of Electronic Publication: 2020 Mar 10.
Typ publikacji :
Journal Article
MeSH Terms :
Acetyl Coenzyme A/*biosynthesis
Arachidonic Acid/*genetics
Genome, Fungal/*genetics
Mortierella/*metabolism
Acetyl Coenzyme A/genetics ; Arachidonic Acid/biosynthesis ; Biosynthetic Pathways/genetics ; Fatty Acid Desaturases/genetics ; Fatty Acid Elongases/genetics ; Fatty Acids, Unsaturated/genetics ; Fatty Acids, Unsaturated/metabolism ; Mortierella/genetics ; Mucorales/genetics ; Mucorales/metabolism ; gamma-Linolenic Acid/genetics ; gamma-Linolenic Acid/metabolism
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Arachidonic acid inhibits inflammatory responses by binding to myeloid differentiation factor-2 (MD2) and preventing MD2/toll-like receptor 4 signaling activation.
Autorzy :
Zhang Y; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China; Affiliated Cangnan Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325800, China.
Chen H; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China; Affiliated Yueqing Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325600, China.
Zhang W; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China; Affiliated Yueqing Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325600, China.
Cai Y; Affiliated Yueqing Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325600, China.
Shan P; Department of Cardiology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325025, China.
Wu D; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Zhang B; Affiliated Cangnan Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325800, China.
Liu H; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Khan ZA; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Liang G; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China; Affiliated Cangnan Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325800, China; Affiliated Yueqing Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325600, China. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Molecular basis of disease [Biochim Biophys Acta Mol Basis Dis] 2020 May 01; Vol. 1866 (5), pp. 165683. Date of Electronic Publication: 2020 Jan 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Acute Lung Injury/*drug therapy
Arachidonic Acid/*pharmacology
Myocarditis/*drug therapy
Obesity/*complications
Sepsis/*drug therapy
Signal Transduction/*drug effects
Acute Lung Injury/immunology ; Animals ; Arachidonic Acid/therapeutic use ; Cell Line ; Diet, High-Fat/adverse effects ; Disease Models, Animal ; Fatty Acids/immunology ; Fatty Acids/metabolism ; Humans ; Lipopolysaccharides/immunology ; Lung/immunology ; Lung/pathology ; Lymphocyte Antigen 96/antagonists & inhibitors ; Lymphocyte Antigen 96/metabolism ; Macrophages/drug effects ; Macrophages/immunology ; Macrophages/metabolism ; Male ; Mice ; Myocarditis/immunology ; Myocarditis/pathology ; Myocardium/immunology ; Myocardium/pathology ; Myocytes, Cardiac ; Obesity/immunology ; Obesity/metabolism ; Palmitic Acid/toxicity ; Primary Cell Culture ; Rats ; Sepsis/immunology ; Signal Transduction/immunology ; Toll-Like Receptor 4/metabolism
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Arachidonic acid promotes the binding of 5-lipoxygenase on nanodiscs containing 5-lipoxygenase activating protein in the absence of calcium-ions.
Autorzy :
Kumar RB; Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden.
Purhonen P; Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden.; Division of Structural Biotechnology, Department of Biomedical Engineering and Health Systems, School of Engineering Sciences in Chemistry, Biotechnology and Health, Royal Institute of Technology, Stockholm, Sweden.
Hebert H; Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden.; Division of Structural Biotechnology, Department of Biomedical Engineering and Health Systems, School of Engineering Sciences in Chemistry, Biotechnology and Health, Royal Institute of Technology, Stockholm, Sweden.
Jegerschöld C; Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden.; Division of Structural Biotechnology, Department of Biomedical Engineering and Health Systems, School of Engineering Sciences in Chemistry, Biotechnology and Health, Royal Institute of Technology, Stockholm, Sweden.
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Źródło :
PloS one [PLoS One] 2020 Jul 09; Vol. 15 (7), pp. e0228607. Date of Electronic Publication: 2020 Jul 09 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
5-Lipoxygenase-Activating Proteins/*metabolism
Arachidonate 5-Lipoxygenase/*metabolism
Arachidonic Acid/*metabolism
Calcium/*metabolism
5-Lipoxygenase-Activating Proteins/chemistry ; Arachidonic Acid/chemistry ; Centrifugation, Density Gradient ; Electrophoresis, Polyacrylamide Gel ; Humans ; Mass Spectrometry ; Microscopy, Electron, Transmission ; Models, Molecular ; Nanostructures/ultrastructure ; Protein Binding ; Protein Conformation ; Sucrose
Czasopismo naukowe
Szczegóły Pełny tekst Pełny tekst
Podgląd okładki
Tytuł :
Epoxyeicosatrienoic acid metabolites inhibit Kir4.1/Kir5.1 in the distal convoluted tubule.
Autorzy :
Wang MX; Department of Physiology, Zhuhai Campus of Zunyi Medical University, Zunyi, Guizhou, China.
Wang LJ; Department of Physiology, Harbin Medical University, Harbin, China.
Xiao Y; Department of Physiology, Qiqihar Medical College, Heilongjiang, China.
Zhang DD; Department of Pharmacology, New York Medical College, Valhalla, New York.
Duan XP; Department of Pharmacology, New York Medical College, Valhalla, New York.
Wang WH; Department of Pharmacology, New York Medical College, Valhalla, New York.
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Źródło :
American journal of physiology. Renal physiology [Am J Physiol Renal Physiol] 2020 Jun 01; Vol. 318 (6), pp. F1369-F1376. Date of Electronic Publication: 2020 Apr 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
8,11,14-Eicosatrienoic Acid/*analogs & derivatives
Arachidonic Acid/*pharmacology
Cytochrome P450 Family 2/*metabolism
Kidney Tubules, Distal/*drug effects
Potassium Channel Blockers/*pharmacology
Potassium Channels, Inwardly Rectifying/*antagonists & inhibitors
8,11,14-Eicosatrienoic Acid/metabolism ; 8,11,14-Eicosatrienoic Acid/pharmacology ; Amides/pharmacology ; Animals ; Arachidonic Acid/metabolism ; Cytochrome P450 Family 2/antagonists & inhibitors ; Cytochrome P450 Family 2/genetics ; Enzyme Inhibitors/pharmacology ; Kidney Tubules, Distal/metabolism ; Male ; Membrane Potentials ; Mice, 129 Strain ; Mice, Knockout ; Potassium Channel Blockers/metabolism ; Potassium Channels, Inwardly Rectifying/metabolism
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Effects of dietary arachidonic acid in European sea bass (Dicentrarchus labrax) distal intestine lipid classes and gut health.
Autorzy :
Rivero-Ramírez F; Grupo de Investigación en Acuicultura (GIA), Instituto Universitario Ecoaqua, University of Las Palmas de Gran Canaria, ULPGC, Crta. Taliarte s/n, 35214, Telde, Las Palmas, Canary Islands, Spain.
Torrecillas S; Grupo de Investigación en Acuicultura (GIA), Instituto Universitario Ecoaqua, University of Las Palmas de Gran Canaria, ULPGC, Crta. Taliarte s/n, 35214, Telde, Las Palmas, Canary Islands, Spain.
Betancor MB; Institute of Aquaculture, School of Natural Sciences, University of Stirling, Stirling, Scotland, FK9 4LA, UK.
Izquierdo MS; Grupo de Investigación en Acuicultura (GIA), Instituto Universitario Ecoaqua, University of Las Palmas de Gran Canaria, ULPGC, Crta. Taliarte s/n, 35214, Telde, Las Palmas, Canary Islands, Spain.
Caballero MJ; Grupo de Investigación en Acuicultura (GIA), Instituto Universitario Ecoaqua, University of Las Palmas de Gran Canaria, ULPGC, Crta. Taliarte s/n, 35214, Telde, Las Palmas, Canary Islands, Spain.
Montero D; Grupo de Investigación en Acuicultura (GIA), Instituto Universitario Ecoaqua, University of Las Palmas de Gran Canaria, ULPGC, Crta. Taliarte s/n, 35214, Telde, Las Palmas, Canary Islands, Spain. .
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Źródło :
Fish physiology and biochemistry [Fish Physiol Biochem] 2020 Apr; Vol. 46 (2), pp. 681-697. Date of Electronic Publication: 2019 Dec 16.
Typ publikacji :
Journal Article
MeSH Terms :
Animal Feed*
Arachidonic Acid*
Diet*
Dietary Supplements*
Fatty Acids*
Fish Oils*
Seafood*
Bass/*physiology
Intestines/*physiology
Animals
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Free radical-dependent inhibition of prostaglandin endoperoxide H Synthase-2 by nitro-arachidonic acid.
Autorzy :
Wood I; Departamento de Bioquímica, Facultad de Medicina, Universidad de la República (UDELAR), Montevideo, Uruguay; Centro de Investigaciones Biomédicas (CEINBIO), Facultad de Medicina, Universidad de la República (UDELAR), Montevideo, Uruguay.
Trostchansky A; Departamento de Bioquímica, Facultad de Medicina, Universidad de la República (UDELAR), Montevideo, Uruguay; Centro de Investigaciones Biomédicas (CEINBIO), Facultad de Medicina, Universidad de la República (UDELAR), Montevideo, Uruguay.
Xu Y; College of Health Professions, North Dakota State University, Fargo, ND, USA.
Qian S; College of Health Professions, North Dakota State University, Fargo, ND, USA.
Radi R; Departamento de Bioquímica, Facultad de Medicina, Universidad de la República (UDELAR), Montevideo, Uruguay; Centro de Investigaciones Biomédicas (CEINBIO), Facultad de Medicina, Universidad de la República (UDELAR), Montevideo, Uruguay.
Rubbo H; Departamento de Bioquímica, Facultad de Medicina, Universidad de la República (UDELAR), Montevideo, Uruguay; Centro de Investigaciones Biomédicas (CEINBIO), Facultad de Medicina, Universidad de la República (UDELAR), Montevideo, Uruguay. Electronic address: .
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Źródło :
Free radical biology & medicine [Free Radic Biol Med] 2019 Nov 20; Vol. 144, pp. 176-182. Date of Electronic Publication: 2019 Mar 25.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Anti-Inflammatory Agents/*chemistry
Arachidonic Acid/*chemistry
Cyclooxygenase 2/*chemistry
Enzyme Inhibitors/*chemistry
Nitro Compounds/*chemistry
Prostaglandin H2/*chemistry
Anti-Inflammatory Agents/metabolism ; Anti-Inflammatory Agents/pharmacology ; Arachidonic Acid/metabolism ; Arachidonic Acid/pharmacology ; Biocatalysis ; Cyclooxygenase 2/metabolism ; Electron Spin Resonance Spectroscopy ; Enzyme Inhibitors/metabolism ; Enzyme Inhibitors/pharmacology ; Heme/chemistry ; Heme/metabolism ; Humans ; Mass Spectrometry ; Nitro Compounds/metabolism ; Nitro Compounds/pharmacology ; Prostaglandin H2/antagonists & inhibitors ; Prostaglandin H2/biosynthesis ; Protein Binding
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Altered brain levels of arachidonic acid-derived inflammatory eicosanoids in a rodent model of anorexia nervosa.
Autorzy :
Collu R; Department of Biomedical Sciences, Division of Neuroscience and Clinical Pharmacology, University of Cagliari, Cagliari, Italy.
Post JM; Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University of Mainz, Mainz, Germany.
Scherma M; Department of Biomedical Sciences, Division of Neuroscience and Clinical Pharmacology, University of Cagliari, Cagliari, Italy.
Giunti E; Department of Biomedical Sciences, Division of Neuroscience and Clinical Pharmacology, University of Cagliari, Cagliari, Italy.
Fratta W; Department of Biomedical Sciences, Division of Neuroscience and Clinical Pharmacology, University of Cagliari, Cagliari, Italy; Centre of Excellence 'Neurobiology of Addiction', University of Cagliari, Cagliari, Italy.
Lutz B; Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University of Mainz, Mainz, Germany.
Fadda P; Department of Biomedical Sciences, Division of Neuroscience and Clinical Pharmacology, University of Cagliari, Cagliari, Italy; Centre of Excellence 'Neurobiology of Addiction', University of Cagliari, Cagliari, Italy; CNR Institute of Neuroscience - Cagliari, National Research Council, Cagliari, Italy; National Neuroscience Institute, Italy. Electronic address: .
Bindila L; Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University of Mainz, Mainz, Germany.
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Źródło :
Biochimica et biophysica acta. Molecular and cell biology of lipids [Biochim Biophys Acta Mol Cell Biol Lipids] 2020 Apr; Vol. 1865 (4), pp. 158578. Date of Electronic Publication: 2019 Nov 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anorexia Nervosa/*pathology
Arachidonic Acid/*analysis
Brain/*pathology
Eicosanoids/*analysis
Inflammation/*pathology
Animals ; Anorexia Nervosa/metabolism ; Arachidonic Acid/metabolism ; Brain/metabolism ; Disease Models, Animal ; Eicosanoids/metabolism ; Female ; Inflammation/metabolism ; Metabolic Networks and Pathways ; Rats, Sprague-Dawley
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Effects of unsaturated fatty acids (Arachidonic/Oleic Acids) on stability and structural properties of Calprotectin using molecular docking and molecular dynamics simulation approach.
Autorzy :
Gheibi N; Cellular and Molecular Research Center, Research Institute for Prevention of Non Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran.
Ghorbani M; Department of Nanobiotechnology/Biophysics, Faculty of Biological Science, Tarbiat Modares University, Tehran, Iran.
Shariatifar H; Young Researchers and Elite Club, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Farasat A; Cellular and Molecular Research Center, Research Institute for Prevention of Non Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran.
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Źródło :
PloS one [PLoS One] 2020 Mar 26; Vol. 15 (3), pp. e0230780. Date of Electronic Publication: 2020 Mar 26 (Print Publication: 2020).
Typ publikacji :
Journal Article
MeSH Terms :
Molecular Docking Simulation*
Molecular Dynamics Simulation*
Arachidonic Acid/*pharmacology
Leukocyte L1 Antigen Complex/*chemistry
Leukocyte L1 Antigen Complex/*metabolism
Oleic Acids/*pharmacology
Arachidonic Acid/metabolism ; Hydrogen Bonding ; Oleic Acids/metabolism ; Protein Conformation/drug effects ; Protein Stability/drug effects
Czasopismo naukowe
Szczegóły Pełny tekst Pełny tekst
Podgląd okładki
Tytuł :
Nitrate and nitrite exposure leads to mild anxiogenic-like behavior and alters brain metabolomic profile in zebrafish.
Autorzy :
García-Jaramillo M; School of Biological and Population Health Sciences, College of Public Health and Human Sciences, Oregon State University, Corvallis, Oregon, United States of America.; Linus Pauling Institute, Oregon State University, Corvallis, Oregon, United States of America.; Department of Chemistry, Oregon State University, Corvallis, Oregon, United States of America.; Helfgott Research Institute, National University of Natural Medicine, Portland, Oregon, United States of America.
Beaver LM; School of Biological and Population Health Sciences, College of Public Health and Human Sciences, Oregon State University, Corvallis, Oregon, United States of America.; Linus Pauling Institute, Oregon State University, Corvallis, Oregon, United States of America.
Truong L; Department of Environmental and Molecular Toxicology, Sinnhuber Aquatic Research Laboratory, Oregon State University, Corvallis, Oregon, United States of America.
Axton ER; Linus Pauling Institute, Oregon State University, Corvallis, Oregon, United States of America.; Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon, United States of America.
Keller RM; School of Biological and Population Health Sciences, College of Public Health and Human Sciences, Oregon State University, Corvallis, Oregon, United States of America.
Prater MC; School of Biological and Population Health Sciences, College of Public Health and Human Sciences, Oregon State University, Corvallis, Oregon, United States of America.
Magnusson KR; Linus Pauling Institute, Oregon State University, Corvallis, Oregon, United States of America.; Department of Biomedical Sciences, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, Oregon, United States of America.
Tanguay RL; Department of Environmental and Molecular Toxicology, Sinnhuber Aquatic Research Laboratory, Oregon State University, Corvallis, Oregon, United States of America.
Stevens JF; Linus Pauling Institute, Oregon State University, Corvallis, Oregon, United States of America.; Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon, United States of America.
Hord NG; School of Biological and Population Health Sciences, College of Public Health and Human Sciences, Oregon State University, Corvallis, Oregon, United States of America.; OU Health, Harold Hamm Diabetes Center, Department of Nutritional Sciences, College of Allied Health, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America.
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Źródło :
PloS one [PLoS One] 2020 Dec 31; Vol. 15 (12), pp. e0240070. Date of Electronic Publication: 2020 Dec 31 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Association Learning/*drug effects
Brain/*drug effects
Executive Function/*drug effects
Metabolome/*drug effects
Nitrates/*pharmacology
Sodium Nitrite/*pharmacology
Animals ; Anxiety/chemically induced ; Anxiety/psychology ; Arachidonic Acid/antagonists & inhibitors ; Arachidonic Acid/metabolism ; Behavior, Animal/drug effects ; Body Size/drug effects ; Body Weight/drug effects ; Brain/metabolism ; Dopamine/metabolism ; Epinephrine/metabolism ; Female ; Glutamine/metabolism ; Linoleic Acid/antagonists & inhibitors ; Linoleic Acid/metabolism ; Male ; Metabolome/physiology ; Norepinephrine/metabolism ; Reflex, Startle/drug effects ; Reinforcement, Psychology ; Zebrafish/metabolism ; gamma-Aminobutyric Acid/metabolism
Czasopismo naukowe
Szczegóły Pełny tekst Pełny tekst
Podgląd okładki
Tytuł :
What about COVID-19 and arachidonic acid pathway?
Autorzy :
Hoxha M; Department of Chemical-Toxicological and Pharmacological Evaluations of Drugs, Faculty of Pharmacy, Catholic University Our Lady of Good Counsel, Rruga Dritan Hoxha, Tirana, Albania. .
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Źródło :
European journal of clinical pharmacology [Eur J Clin Pharmacol] 2020 Nov; Vol. 76 (11), pp. 1501-1504. Date of Electronic Publication: 2020 Jun 25.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Arachidonic Acid/*biosynthesis
Coronavirus Infections/*physiopathology
Cyclooxygenase 2/*biosynthesis
Inflammation/*metabolism
Pneumonia, Viral/*physiopathology
Prostaglandin-E Synthases/*biosynthesis
Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Betacoronavirus ; COVID-19 ; Cyclooxygenase 2/blood ; Humans ; Pandemics ; Phospholipases A2/biosynthesis ; Prostaglandin-E Synthases/blood ; Prostaglandins/biosynthesis ; Prostaglandins/blood ; Protein-Lysine 6-Oxidase/biosynthesis ; SARS-CoV-2 ; Sex Factors
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
The Effects of Lipid-Lowering Therapy on Serum Eicosapentaenoic Acid to Arachidonic Acid Ratio: An HIJ-PROPER Sub-Analysis.
Autorzy :
Arashi H; Department of Cardiology, The Heart Institute of Japan, 13131Tokyo Women's Medical University, Tokyo, Japan.
Yamaguchi J; Department of Cardiology, The Heart Institute of Japan, 13131Tokyo Women's Medical University, Tokyo, Japan.
Kawada-Watanabe E; Department of Cardiology, The Heart Institute of Japan, 13131Tokyo Women's Medical University, Tokyo, Japan.
Otsuki H; Department of Cardiology, The Heart Institute of Japan, 13131Tokyo Women's Medical University, Tokyo, Japan.
Sekiguchi H; Department of Cardiology, The Heart Institute of Japan, 13131Tokyo Women's Medical University, Tokyo, Japan.
Ogawa H; Department of Cardiology, The Heart Institute of Japan, 13131Tokyo Women's Medical University, Tokyo, Japan.
Hagiwara N; Department of Cardiology, The Heart Institute of Japan, 13131Tokyo Women's Medical University, Tokyo, Japan.
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Źródło :
Journal of cardiovascular pharmacology and therapeutics [J Cardiovasc Pharmacol Ther] 2020 Nov; Vol. 25 (6), pp. 548-555. Date of Electronic Publication: 2020 Jun 22.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Acute Coronary Syndrome/*drug therapy
Anticholesteremic Agents/*therapeutic use
Arachidonic Acid/*blood
Eicosapentaenoic Acid/*blood
Ezetimibe/*therapeutic use
Hydroxymethylglutaryl-CoA Reductase Inhibitors/*therapeutic use
Quinolines/*therapeutic use
Acute Coronary Syndrome/blood ; Acute Coronary Syndrome/diagnosis ; Aged ; Anticholesteremic Agents/adverse effects ; Biomarkers/blood ; Ezetimibe/adverse effects ; Female ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects ; Japan ; Male ; Middle Aged ; Multicenter Studies as Topic ; Quinolines/adverse effects ; Randomized Controlled Trials as Topic ; Retrospective Studies ; Time Factors ; Treatment Outcome
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Novel nanoarchitecture of arginine-glycine-aspartate conjugated gold nanoparticles: a sensitive and selective platform for detecting arachidonic acid.
Autorzy :
Zhang N; Environmental Science Research Institute, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Nanjing Normal University, Nanjing, 210097, Jiangsu, China.
Li J; Neurosurgery Department, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing, 210029, Jiangsu, China.
Zhang P; Environmental Science Research Institute, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Nanjing Normal University, Nanjing, 210097, Jiangsu, China.
Yang X; Environmental Science Research Institute, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Nanjing Normal University, Nanjing, 210097, Jiangsu, China. .
Sun C; Institute of Agricultural Products Processing, Jiangsu Academy of Agricultural Sciences, Nanjing, 210014, Jiangsu, China. .
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Źródło :
Analytical and bioanalytical chemistry [Anal Bioanal Chem] 2019 Nov; Vol. 411 (27), pp. 7105-7113. Date of Electronic Publication: 2019 Sep 12.
Typ publikacji :
Journal Article
MeSH Terms :
Arachidonic Acid/*analysis
Arginine/*chemistry
Aspartic Acid/*chemistry
Glycine/*chemistry
Gold/*chemistry
Nanoparticles/*chemistry
Arachidonic Acid/blood ; Electrochemical Techniques/methods ; Electrolytes/chemistry ; Humans ; Limit of Detection ; Reproducibility of Results ; Spectrum Analysis/methods
Czasopismo naukowe
Szczegóły Pełny tekst Pełny tekst
Podgląd okładki
Tytuł :
Arachidonic acid exacerbates diet-induced obesity and reduces bone mineral content without impacting bone strength in growing male rats.
Autorzy :
Mak IL; School of Human Nutrition, McGill University, 21111 Lakeshore Road, Ste-Anne-de-Bellevue, QC, Canada H9X 3V9.
Lavery P; School of Human Nutrition, McGill University, 21111 Lakeshore Road, Ste-Anne-de-Bellevue, QC, Canada H9X 3V9.
Agellon S; School of Human Nutrition, McGill University, 21111 Lakeshore Road, Ste-Anne-de-Bellevue, QC, Canada H9X 3V9.
Rauch F; Shriners' Hospital for Children, 1003 Decarie Boulevard, Montreal, QC, Canada H4A 0A9.
Murshed M; Shriners' Hospital for Children, 1003 Decarie Boulevard, Montreal, QC, Canada H4A 0A9; Faculty of Dentistry, McGill University, 3640 rue University, Montreal, QC, Canada H3A 0C7.
Weiler HA; School of Human Nutrition, McGill University, 21111 Lakeshore Road, Ste-Anne-de-Bellevue, QC, Canada H9X 3V9. Electronic address: .
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Źródło :
The Journal of nutritional biochemistry [J Nutr Biochem] 2019 Nov; Vol. 73, pp. 108226. Date of Electronic Publication: 2019 Aug 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Arachidonic Acid/*adverse effects
Bone Density/*drug effects
Bone and Bones/*physiopathology
Diet, High-Fat/*adverse effects
Obesity/*etiology
3T3-L1 Cells ; Adipocytes/drug effects ; Adiposity/drug effects ; Animals ; Arachidonic Acid/administration & dosage ; Biomechanical Phenomena ; Body Composition/drug effects ; Bone Resorption/etiology ; Bone and Bones/drug effects ; Energy Intake ; Fatty Acids/pharmacology ; Femur/drug effects ; Femur/pathology ; Leptin/blood ; Male ; Mice ; Obesity/pathology ; Obesity/physiopathology ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Impacts of vesicular environment on Nox2 activity measurements in vitro.
Autorzy :
Serfaty X; Université Paris-Saclay, CNRS, Institut de Chimie Physique, UMR8000, 91405, Orsay, France.
Lefrançois P; Univ. Bordeaux, ISM, CNRS UMR 5255, NSysA group, ENSCBP, 33607 Pessac, France.
Houée-Levin C; Université Paris-Saclay, CNRS, Institut de Chimie Physique, UMR8000, 91405, Orsay, France.
Arbault S; Univ. Bordeaux, ISM, CNRS UMR 5255, NSysA group, ENSCBP, 33607 Pessac, France.
Baciou L; Université Paris-Saclay, CNRS, Institut de Chimie Physique, UMR8000, 91405, Orsay, France.
Bizouarn T; Université Paris-Saclay, CNRS, Institut de Chimie Physique, UMR8000, 91405, Orsay, France. Electronic address: .
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Źródło :
Biochimica et biophysica acta. General subjects [Biochim Biophys Acta Gen Subj] 2021 Jan; Vol. 1865 (1), pp. 129767. Date of Electronic Publication: 2020 Oct 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
NADPH Oxidase 2/*metabolism
Arachidonic Acid/metabolism ; Cells, Cultured ; Cytochromes c/metabolism ; Humans ; Hydrogen Peroxide/metabolism ; NADP/metabolism ; Neutrophils/metabolism ; Oxidation-Reduction ; Oxygen Consumption
Czasopismo naukowe
Szczegóły
Wyświetlanie 1-20 z 66353

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