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Tytuł:
A twin convolutional neural network with hybrid binary optimizer for multimodal breast cancer digital image classification.
Autorzy:
Oyelade ON; School of Electronics, Electrical Engineering and Computer Science, Queen's University Belfast, Belfast, BT9 SBN, UK. .
Irunokhai EA; Department of Computer Science, Federal College of Wildlife Management, New-Bussa, Nigeria.
Wang H; School of Electronics, Electrical Engineering and Computer Science, Queen's University Belfast, Belfast, BT9 SBN, UK.
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Źródło:
Scientific reports [Sci Rep] 2024 Jan 06; Vol. 14 (1), pp. 692. Date of Electronic Publication: 2024 Jan 06.
Typ publikacji:
Journal Article
MeSH Terms:
Mammography*
Neoplasms*
Area Under Curve ; Benchmarking ; Histological Techniques ; Neural Networks, Computer
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A spatiotemporal computational model of focused ultrasound heat-induced nano-sized drug delivery system in solid tumors.
Autorzy:
Moradi Kashkooli F; Department of Physics, Toronto Metropolitan University, Toronto, ON, Canada.
Souri M; Department of Nanobiotechnology, Pasture Institute of Iran, Tehran, Iran.
Tavakkoli JJ; Department of Physics, Toronto Metropolitan University, Toronto, ON, Canada.; Institute for Biomedical Engineering, Science and Technology (iBEST), Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, ON, Canada.
C Kolios M; Department of Physics, Toronto Metropolitan University, Toronto, ON, Canada.; Institute for Biomedical Engineering, Science and Technology (iBEST), Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, ON, Canada.
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Źródło:
Drug delivery [Drug Deliv] 2023 Dec; Vol. 30 (1), pp. 2219871.
Typ publikacji:
Journal Article
MeSH Terms:
Hot Temperature*
Neoplasms*/drug therapy
Humans ; Area Under Curve ; Biological Transport ; Doxorubicin ; Drug Delivery Systems ; Nanoparticle Drug Delivery System
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Effect of itraconazole and fluconazole on the pharmacokinetics of valemetostat: An open-label, phase I study in healthy subjects.
Autorzy:
Tachibana M; Daiichi Sankyo Co., Ltd., Tokyo, Japan.
Matsuki S; Souseikai Fukuoka Mirai Hospital, Fukuoka, Japan.
Maekawa Y; Daiichi Sankyo Co., Ltd., Tokyo, Japan.
Kuroda K; Daiichi Sankyo Co., Ltd., Tokyo, Japan.
Shimizu T; Daiichi Sankyo Co., Ltd., Tokyo, Japan.
Tsutsumi J; Daiichi Sankyo Co., Ltd., Tokyo, Japan.
Ishizuka H; Daiichi Sankyo Co., Ltd., Tokyo, Japan.
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Źródło:
Clinical and translational science [Clin Transl Sci] 2023 Nov; Vol. 16 (11), pp. 2153-2162. Date of Electronic Publication: 2023 Sep 13.
Typ publikacji:
Clinical Trial, Phase I; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms:
Itraconazole*/adverse effects
Neoplasms*
Humans ; Male ; Area Under Curve ; Cross-Over Studies ; Cytochrome P-450 CYP3A/metabolism ; Cytochrome P-450 CYP3A Inhibitors ; Drug Interactions ; Enzyme Inhibitors ; Fluconazole/adverse effects ; Healthy Volunteers
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Pharmacokinetics and Comparative Bioavailability of Test or Reference Capecitabine and Discrepant Pharmacokinetics Among Various Tumors in Chinese Solid Cancer Patients.
Autorzy:
Li X; Clinical Trial Center, National Medical Products Administration Key Laboratory for Clinical Research and Evaluation of Innovative Drugs, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Cui D; Jiangsu Hengrui Medicine Co. Ltd., Lianyungang, Jiangsu, China.
Xiong J; Department of Oncology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Dang Q; Department of Oncology, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong, China.
Wen Q; Jinan Central Hospital Affiliated to Shandong University, Jinan, China.
Yan M; Henan Breast Cancer Centre, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou City, Henan Province, China.
Li H; Department of Pharmacology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou City, Henan Province, China.
Jiang X; Department of Oncology, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang, Jiangsu, China.
Lin C; Department of Pharmacy, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Xie X; Department of Medical Oncology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China.
Wang T; Department of Oncology, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, China.
Xiang L; Clinical Trial Center, National Medical Products Administration Key Laboratory for Clinical Research and Evaluation of Innovative Drugs, West China Hospital, Sichuan University, Chengdu, Sichuan, China.; Thoracic Oncology Ward, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Wang Y; Thoracic Oncology Ward, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Zheng L; Clinical Trial Center, National Medical Products Administration Key Laboratory for Clinical Research and Evaluation of Innovative Drugs, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
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Źródło:
Clinical pharmacology in drug development [Clin Pharmacol Drug Dev] 2023 Mar; Vol. 12 (3), pp. 324-332. Date of Electronic Publication: 2023 Jan 15.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Capecitabine*/pharmacokinetics
Neoplasms*/drug therapy
Humans ; Area Under Curve ; Biological Availability ; East Asian People ; Fluorouracil ; Tablets
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Fractionated oral dosing and its effect on cyclophosphamide pharmacokinetics in dogs with high-grade multicentric lymphoma.
Autorzy:
Veluvolu S; William R Pritchard Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California-Davis, Davis, California, USA.
Willcox JL; William R Pritchard Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California-Davis, Davis, California, USA.; Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, California, USA.
Skorupski KA; William R Pritchard Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California-Davis, Davis, California, USA.; Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, California, USA.
Al-Nadaf S; William R Pritchard Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California-Davis, Davis, California, USA.; Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, California, USA.
Rebhun R; William R Pritchard Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California-Davis, Davis, California, USA.; Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, California, USA.
Wittenburg L; Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, California, USA.
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Źródło:
Veterinary and comparative oncology [Vet Comp Oncol] 2023 Mar; Vol. 21 (1), pp. 20-27. Date of Electronic Publication: 2022 Sep 14.
Typ publikacji:
Journal Article
MeSH Terms:
Dog Diseases*/drug therapy
Neoplasms*/veterinary
Lymphoma, Non-Hodgkin*/veterinary
Humans ; Dogs ; Animals ; Cyclophosphamide ; Area Under Curve
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Study on pharmacokinetic interactions between SHR2554 and itraconazole in healthy subjects: A single-center, open-label phase I trial.
Autorzy:
Deng K; Center of Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, China.
Zou Y; School of Mathematics and Statistics, Central South University, Changsha, China.
Zou C; Center of Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, China.
Wang H; School of Mathematics and Statistics, Central South University, Changsha, China.
Xiang Y; Center of Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, China.; Research Center of Drug Clinical Evaluation of Central South University, Changsha, China.
Yang X; Center of Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, China.
Yang S; Center of Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, China.
Cui C; Center of Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, China.
Yang G; Center of Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, China.; Research Center of Drug Clinical Evaluation of Central South University, Changsha, China.; Department of Pharmacy, The Third Xiangya Hospital, Central South University, Changsha, China.; XiangYa School of Pharmaceutical Sciences, Central South University, Changsha, China.; National-Local Joint Engineering Laboratory of Drug Clinical Evaluation Technology, Changsha, China.
Huang J; Center of Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, China.; Research Center of Drug Clinical Evaluation of Central South University, Changsha, China.
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Źródło:
Cancer medicine [Cancer Med] 2023 Jan; Vol. 12 (2), pp. 1431-1440. Date of Electronic Publication: 2022 Jul 16.
Typ publikacji:
Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Itraconazole*/pharmacology
Neoplasms*
Humans ; Cytochrome P-450 CYP3A ; Healthy Volunteers ; Enzyme Inhibitors ; Area Under Curve ; Cross-Over Studies
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Vancomycin therapeutic monitoring by measured trough concentration versus Bayesian-derived area under the curve in critically ill patients with cancer.
Autorzy:
AbuSara AK; Department of Pharmacy, King Hussein Cancer Center, Amman, Jordan.
Abdelrahman DH; Department of Pharmacy, King Hussein Cancer Center, Amman, Jordan.
Habash KI; Department of Pharmacy, King Hussein Cancer Center, Amman, Jordan.
Al-Shaer MH; Infectious Disease Pharmacokinetics Laboratory, College of Pharmacy, University of Florida, Gainesville, Florida, USA.
Le J; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, USA.
Nazer LH; Department of Pharmacy, King Hussein Cancer Center, Amman, Jordan.
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Źródło:
Pharmacology research & perspectives [Pharmacol Res Perspect] 2022 Feb; Vol. 10 (1), pp. e00912.
Typ publikacji:
Comparative Study; Journal Article
MeSH Terms:
Anti-Bacterial Agents/*pharmacokinetics
Drug Monitoring/*methods
Neoplasms/*pathology
Vancomycin/*pharmacokinetics
Adult ; Aged ; Anti-Bacterial Agents/administration & dosage ; Area Under Curve ; Bayes Theorem ; Cohort Studies ; Critical Illness ; Female ; Humans ; Male ; Microbial Sensitivity Tests ; Middle Aged ; Retrospective Studies ; Vancomycin/administration & dosage
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
gGATLDA: lncRNA-disease association prediction based on graph-level graph attention network.
Autorzy:
Wang L; School of Computer Science and Engineering, South China University of Technology, Guangzhou, China.; School of Computer, Electronics and Information, Guangxi University, Nanning, China.
Zhong C; School of Computer, Electronics and Information, Guangxi University, Nanning, China. .; Key Laboratory of Parallel and Distributed Computing in Guangxi Colleges and Universities, Guangxi University, Nanning, China. .
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Źródło:
BMC bioinformatics [BMC Bioinformatics] 2022 Jan 04; Vol. 23 (1), pp. 11. Date of Electronic Publication: 2022 Jan 04.
Typ publikacji:
Journal Article
MeSH Terms:
RNA, Long Noncoding*/genetics
Neoplasms/*genetics
Algorithms ; Area Under Curve ; Computational Biology ; Humans ; Neural Networks, Computer
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
XOmiVAE: an interpretable deep learning model for cancer classification using high-dimensional omics data.
Autorzy:
Withnell E; Data Science Institute Imperial College London, SW7 2AZ London, UK.; Department of Health Informatics University College London, WC1E 6BT London, UK.
Zhang X; Data Science Institute Imperial College London, SW7 2AZ London, UK.
Sun K; Data Science Institute Imperial College London, SW7 2AZ London, UK.
Guo Y; Data Science Institute Imperial College London, SW7 2AZ London, UK.; Department of Computer Science Hong Kong Baptist University, Hong Kong China.
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Źródło:
Briefings in bioinformatics [Brief Bioinform] 2021 Nov 05; Vol. 22 (6).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Deep Learning*
Machine Learning*
Computational Biology/*methods
Genomics/*methods
Neoplasms/*diagnosis
Neoplasms/*etiology
Algorithms ; Area Under Curve ; Biomarkers, Tumor ; Cluster Analysis ; Computational Biology/standards ; Databases, Genetic ; Female ; Gene Expression Profiling/methods ; Gene Regulatory Networks ; Genomics/standards ; Humans ; Male ; Neoplasms/metabolism ; ROC Curve ; Reproducibility of Results ; Signal Transduction
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
TRIM59: A potential diagnostic and prognostic biomarker in human tumors.
Autorzy:
Jin Z; Department of Immunology, College of Basic Medical Sciences, Jilin University, Changchun City, Jilin Province, China.
Liu L; Department of Immunology, College of Basic Medical Sciences, Jilin University, Changchun City, Jilin Province, China.
Yu Y; College of Pharmacy, Shanghai University of Medicine & Health Sciences, Shanghai, China.
Li D; Department of Immunology, College of Basic Medical Sciences, Jilin University, Changchun City, Jilin Province, China.
Zhu X; Department of Immunology, College of Basic Medical Sciences, Jilin University, Changchun City, Jilin Province, China.
Yan D; Department of Immunology, College of Basic Medical Sciences, Jilin University, Changchun City, Jilin Province, China.
Zhu Z; Department of Orthopaedic Trauma, Center for Orthopaedic Surgery, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong Province, China.
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Źródło:
PloS one [PLoS One] 2021 Sep 17; Vol. 16 (9), pp. e0257445. Date of Electronic Publication: 2021 Sep 17 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Biomarkers, Tumor/*metabolism
Intracellular Signaling Peptides and Proteins/*metabolism
Neoplasms/*diagnosis
Tripartite Motif Proteins/*metabolism
Area Under Curve ; Databases, Factual ; Humans ; Neoplasms/mortality ; Neoplasms/pathology ; Prognosis ; ROC Curve ; Survival Analysis ; Up-Regulation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Predicting severe outcomes using national early warning score (NEWS) in patients identified by a rapid response system: a retrospective cohort study.
Autorzy:
Kim SH; Division of Pulmonology and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Choi HS; Department of Rapid Response Team, Advanced Practice Nurse, Hallym University Chuncheon Sacred Heart Hospital, Chuncheon, Korea.
Jin ES; Department of Rapid Response Team, Advanced Practice Nurse, Hallym University Chuncheon Sacred Heart Hospital, Chuncheon, Korea.
Choi H; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Hallym University Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.
Lee H; Division of Pulmonary Medicine and Allergy, Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.
Lee SH; Department of Neurology, Hallym University Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon, Korea.
Lee CY; Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Hallym University Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, 77, Sakju-ro, Chuncheon, Gangwon-do, 24253, Korea.
Lee MG; Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Hallym University Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, 77, Sakju-ro, Chuncheon, Gangwon-do, 24253, Korea.
Kim Y; Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Hallym University Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, 77, Sakju-ro, Chuncheon, Gangwon-do, 24253, Korea. .
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Źródło:
Scientific reports [Sci Rep] 2021 Sep 09; Vol. 11 (1), pp. 18021. Date of Electronic Publication: 2021 Sep 09.
Typ publikacji:
Journal Article
MeSH Terms:
Early Warning Score*
Gastrointestinal Diseases/*mortality
Lung Diseases/*mortality
Neoplasms/*mortality
Urologic Diseases/*mortality
Aged ; Aged, 80 and over ; Area Under Curve ; Body Temperature ; Critical Illness ; Female ; Gastrointestinal Diseases/diagnosis ; Gastrointestinal Diseases/pathology ; Hospital Mortality ; Hospital Rapid Response Team/organization & administration ; Humans ; Intensive Care Units ; Logistic Models ; Lung Diseases/diagnosis ; Lung Diseases/pathology ; Male ; Middle Aged ; Neoplasms/diagnosis ; Neoplasms/pathology ; ROC Curve ; Republic of Korea ; Retrospective Studies ; Survival Analysis ; Urologic Diseases/diagnosis ; Urologic Diseases/pathology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
SGANRDA: semi-supervised generative adversarial networks for predicting circRNA-disease associations.
Autorzy:
Wang L; Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, China.
Yan X; School of Computer Science and Technology, China University of Mining and Technology, Xuzhou, 221116, China.
You ZH; Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, China.
Zhou X; Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, China.
Li HY; School of Computer Science and Technology, China University of Mining and Technology, Xuzhou, 221116, China.
Huang YA; Department of Computing, Hong Kong Polytechnic University, Hong Kong, China.
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Źródło:
Briefings in bioinformatics [Brief Bioinform] 2021 Sep 02; Vol. 22 (5).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Deep Learning*
Gene Regulatory Networks*
Multiple Sclerosis/*genetics
Myocardial Infarction/*genetics
Neoplasms/*genetics
Osteoarthritis/*genetics
RNA, Circular/*genetics
Area Under Curve ; Computational Biology/methods ; Databases, Genetic ; Datasets as Topic ; Gene Expression Regulation ; Humans ; Multiple Sclerosis/metabolism ; Multiple Sclerosis/pathology ; Myocardial Infarction/metabolism ; Myocardial Infarction/pathology ; Neoplasms/classification ; Neoplasms/metabolism ; Neoplasms/pathology ; Osteoarthritis/metabolism ; Osteoarthritis/pathology ; RNA, Circular/classification ; RNA, Circular/metabolism ; Risk Factors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Predictive Value of IL-6 Combined with NLR in Inflammation and Cancer.
Autorzy:
Yuan C; School of Laboratory Medicine, Hubei University of Chinese Medicine, Wuhan, China.; Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, China.
Pan Y; Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, China.; Center for Gene Diagnosis, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, China.
Ning Y; School of Laboratory Medicine, Hubei University of Chinese Medicine, Wuhan, China.
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Źródło:
Cancer investigation [Cancer Invest] 2021 Jul-Aug; Vol. 39 (6-7), pp. 489-504. Date of Electronic Publication: 2021 Jun 18.
Typ publikacji:
Journal Article
MeSH Terms:
Inflammation/*diagnosis
Interleukin-6/*metabolism
Neoplasms/*diagnosis
Neutrophils/*metabolism
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Area Under Curve ; Child ; Female ; Humans ; Inflammation/immunology ; Lymphocyte Count ; Male ; Middle Aged ; Neoplasms/immunology ; Predictive Value of Tests ; Prognosis ; ROC Curve ; Retrospective Studies ; Young Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A Phase 1 Dose-Escalation Study of Low-Dose Metronomic Treatment With Novel Oral Paclitaxel Formulations in Combination With Ritonavir in Patients With Advanced Solid Tumors.
Autorzy:
de Weger VA; Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Vermunt MAC; Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Stuurman FE; Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Burylo AM; Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Damoiseaux D; Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Hendrikx JJMA; Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.; Department of Nuclear Medicine, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Sawicki E; Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.; Modra Pharmaceuticals BV, Amsterdam, The Netherlands.
Moes JJ; Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Huitema ADR; Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.; Department of Clinical Pharmacy, University Medical Center Utrecht, Utrecht University, The Netherlands.
Nuijen B; Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Rosing H; Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Mergui-Roelvink M; Division of Clinical Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Beijnen JH; Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.; Modra Pharmaceuticals BV, Amsterdam, The Netherlands.; Department of Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.
Marchetti S; Division of Clinical Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
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Źródło:
Clinical pharmacology in drug development [Clin Pharmacol Drug Dev] 2021 Jun; Vol. 10 (6), pp. 607-621. Date of Electronic Publication: 2020 Oct 05.
Typ publikacji:
Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antineoplastic Combined Chemotherapy Protocols/*administration & dosage
Neoplasms/*drug therapy
Administration, Oral ; Aged ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/pharmacokinetics ; Area Under Curve ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Female ; Humans ; Male ; Maximum Tolerated Dose ; Middle Aged ; Paclitaxel/administration & dosage ; Ritonavir/administration & dosage
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Spinal block and delirium in oncologic patients after laparoscopic surgery in the Trendelenburg position: A randomized controlled trial.
Autorzy:
Mitsunaga JK Junior; Department of Anaesthesiology, A.C.Camargo Cancer Center, São Paulo, Brazil.
Calsavara VF; Department of Epidemiology and Statistics, A.C.Camargo Cancer Center, São Paulo, Brazil.
Onari ES; Department of Anaesthesiology, A.C.Camargo Cancer Center, São Paulo, Brazil.
Arantes VM; Department of Anaesthesiology, A.C.Camargo Cancer Center, São Paulo, Brazil.
Akamine CP; Department of Anaesthesiology, A.C.Camargo Cancer Center, São Paulo, Brazil.
Handa AM; Department of Anaesthesiology, A.C.Camargo Cancer Center, São Paulo, Brazil.
Quezada MMC; Department of Anaesthesiology, A.C.Camargo Cancer Center, São Paulo, Brazil.
Ito FY; Department of Anaesthesiology, A.C.Camargo Cancer Center, São Paulo, Brazil.
Porto ACS; Department of Cutaneous Oncology, A.C.Camargo Cancer Center, São Paulo, Brazil.
Giroud Joaquim EH; Department of Anaesthesiology, A.C.Camargo Cancer Center, São Paulo, Brazil.
Nakamura G; Department of Anaesthesiology, A.C.Camargo Cancer Center, São Paulo, Brazil.
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Źródło:
PloS one [PLoS One] 2021 May 17; Vol. 16 (5), pp. e0249808. Date of Electronic Publication: 2021 May 17 (Print Publication: 2021).
Typ publikacji:
Journal Article; Randomized Controlled Trial
MeSH Terms:
Delirium/*etiology
Laparoscopy/*adverse effects
Neoplasms/*surgery
Aged ; Anesthesia, General/adverse effects ; Area Under Curve ; Delirium/diagnosis ; Female ; Head-Down Tilt ; Hemodynamics ; Humans ; Logistic Models ; Male ; Middle Aged ; Neoplasms/pathology ; Odds Ratio ; Postoperative Period ; ROC Curve
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Projecting COVID-19 disease severity in cancer patients using purposefully-designed machine learning.
Autorzy:
Navlakha S; Simons Center for Quantitative Biology, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
Morjaria S; Infectious Disease, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY, USA.
Perez-Johnston R; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Zhang A; MD/PhD Program, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
Taur Y; Infectious Disease, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. .; Department of Medicine, Weill Cornell Medical College, New York, NY, USA. .
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Źródło:
BMC infectious diseases [BMC Infect Dis] 2021 May 04; Vol. 21 (1), pp. 391. Date of Electronic Publication: 2021 May 04.
Typ publikacji:
Journal Article
MeSH Terms:
Decision Support Systems, Clinical*
Machine Learning*
Risk Factors*
COVID-19/*etiology
Neoplasms/*etiology
Aged ; Aged, 80 and over ; Algorithms ; Area Under Curve ; COVID-19/epidemiology ; COVID-19/therapy ; Comorbidity ; Female ; Humans ; Male ; Middle Aged ; Neoplasms/epidemiology ; Neoplasms/virology ; New York City/epidemiology ; Prognosis ; ROC Curve ; Respiration, Artificial ; Retrospective Studies ; Severity of Illness Index
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The ROC of Cox proportional hazards cure models with application in cancer studies.
Autorzy:
Zhang Y; Department of Biostatistics and Research Decision Sciences, Merck & Co., Inc, Kenilworth, NJ, USA.
Han X; Department of Public Health Sciences, Henry Ford Health System, Detroit, MI, USA.
Shao Y; Departments of Population Health & Environmental Medicine, NYU Grossman School of Medicine, 180 Madison Ave, 4th Floor, Suite 455, New York, NY, 10016, USA. .
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Źródło:
Lifetime data analysis [Lifetime Data Anal] 2021 Apr; Vol. 27 (2), pp. 195-215. Date of Electronic Publication: 2021 Jan 28.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Models, Statistical*
Neoplasms*
Area Under Curve ; Humans ; Proportional Hazards Models ; ROC Curve
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Optimizing the Therapeutic Window of Targeted Drugs in Oncology: Potency-Guided First-in-Human Studies.
Autorzy:
Goldstein MJ; Tango Therapeutics, Cambridge, Massachusetts, USA.
Peters M; MorphoSys AG, Planegg, Germany.
Weber BL; Tango Therapeutics, Cambridge, Massachusetts, USA.
Davis CB; Tango Therapeutics, Cambridge, Massachusetts, USA.
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Źródło:
Clinical and translational science [Clin Transl Sci] 2021 Mar; Vol. 14 (2), pp. 536-543. Date of Electronic Publication: 2020 Oct 28.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents/*administration & dosage
Clinical Trials, Phase I as Topic/*methods
Neoplasms/*drug therapy
Poly(ADP-ribose) Polymerase Inhibitors/*administration & dosage
Protein Kinase Inhibitors/*administration & dosage
Antineoplastic Agents/pharmacokinetics ; Area Under Curve ; Cell Line, Tumor ; Dose-Response Relationship, Drug ; Humans ; Inhibitory Concentration 50 ; Maximum Tolerated Dose ; Poly(ADP-ribose) Polymerase Inhibitors/pharmacokinetics ; Protein Kinase Inhibitors/pharmacokinetics ; Research Design
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Plasma metabolomic profile associated with fatigue in cancer patients.
Autorzy:
Feng LR; National Institute of Nursing Research, National Institutes of Health, Bethesda, MD, USA.
Barb JJ; Clinical Center, National Institutes of Health, Bethesda, MD, USA.
Regan J; The Pennsylvania State University College of Medicine, Hershey, PA, USA.
Saligan LN; National Institute of Nursing Research, National Institutes of Health, Bethesda, MD, USA.
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Źródło:
Cancer medicine [Cancer Med] 2021 Mar; Vol. 10 (5), pp. 1623-1633. Date of Electronic Publication: 2021 Feb 03.
Typ publikacji:
Journal Article; Research Support, N.I.H., Intramural
MeSH Terms:
Metabolome*
Fatigue/*blood
Metabolomics/*methods
Neoplasms/*blood
Aged ; Area Under Curve ; Body Mass Index ; Chromatography, High Pressure Liquid ; Discriminant Analysis ; Fatigue/etiology ; Humans ; Male ; Mass Spectrometry ; Metabolic Networks and Pathways ; Neoplasms/complications ; ROC Curve
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Effect of Food on the Pharmacokinetics of the Oral Docetaxel Tablet Formulation ModraDoc006 Combined with Ritonavir (ModraDoc006/r) in Patients with Advanced Solid Tumours.
Autorzy:
Vermunt MAC; Department of Pharmacy and Pharmacology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands. .
de Weger VA; Department of Pharmacy and Pharmacology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands.
Janssen JM; Department of Pharmacy and Pharmacology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands.
Lopez-Yurda MI; Department of Biometrics, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Keessen M; Modra Pharmaceuticals BV, Amsterdam, The Netherlands.
Thijssen B; Department of Pharmacy and Pharmacology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands.
Rosing H; Department of Pharmacy and Pharmacology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands.
Huitema ADR; Department of Pharmacy and Pharmacology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands.; Department of Clinical Pharmacy, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Beijnen JH; Department of Pharmacy and Pharmacology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands.; Modra Pharmaceuticals BV, Amsterdam, The Netherlands.; Department of Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.
Marchetti S; Department of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
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Źródło:
Drugs in R&D [Drugs R D] 2021 Mar; Vol. 21 (1), pp. 103-111. Date of Electronic Publication: 2021 Jan 19.
Typ publikacji:
Clinical Trial; Journal Article; Randomized Controlled Trial
MeSH Terms:
Antineoplastic Agents/*pharmacokinetics
Cytochrome P-450 CYP3A Inhibitors/*pharmacokinetics
Docetaxel/*pharmacokinetics
Neoplasms/*drug therapy
Ritonavir/*pharmacokinetics
Administration, Oral ; Aged ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/adverse effects ; Antineoplastic Agents/blood ; Area Under Curve ; Cross-Over Studies ; Cytochrome P-450 CYP3A Inhibitors/administration & dosage ; Cytochrome P-450 CYP3A Inhibitors/adverse effects ; Diarrhea/chemically induced ; Diet, High-Fat ; Docetaxel/administration & dosage ; Docetaxel/adverse effects ; Docetaxel/blood ; Drug Combinations ; Fasting ; Fatigue/chemically induced ; Female ; Food-Drug Interactions ; Humans ; Hypokalemia/chemically induced ; Male ; Middle Aged ; Ritonavir/administration & dosage ; Ritonavir/adverse effects ; Ritonavir/blood ; Tablets ; Therapeutic Equivalency
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
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