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Tytuł :
Melanoma-associated fibroblasts impair CD8+ T cell function and modify expression of immune checkpoint regulators via increased arginase activity.
Autorzy :
Érsek B; Department of Genetics, Cell and Immunobiology, Semmelweis University, 4 Nagyvarad ter, VII/709, Budapest, 1089, Hungary.; Office for Research Groups Attached to Universities and Other Institutions of the Hungarian Academy of Sciences, Budapest, 1051, Hungary.
Silló P; Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Budapest, 1085, Hungary.
Cakir U; Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Budapest, 1085, Hungary.
Molnár V; Institute of Genomic Medicine and Rare Disorders, Semmelweis University, Budapest, 1083, Hungary.
Bencsik A; Department of Genetics, Cell and Immunobiology, Semmelweis University, 4 Nagyvarad ter, VII/709, Budapest, 1089, Hungary.
Mayer B; Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Budapest, 1085, Hungary.
Mezey E; National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, 20815, USA.
Kárpáti S; Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Budapest, 1085, Hungary.
Pós Z; Department of Genetics, Cell and Immunobiology, Semmelweis University, 4 Nagyvarad ter, VII/709, Budapest, 1089, Hungary. .
Németh K; Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Budapest, 1085, Hungary.
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Źródło :
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2021 Jan; Vol. 78 (2), pp. 661-673. Date of Electronic Publication: 2020 Apr 23.
Typ publikacji :
Journal Article
MeSH Terms :
Arginase/*immunology
CD8-Positive T-Lymphocytes/*immunology
Cancer-Associated Fibroblasts/*immunology
Immune Checkpoint Proteins/*immunology
Melanoma/*immunology
Skin Neoplasms/*immunology
Arginase/genetics ; CD8-Positive T-Lymphocytes/metabolism ; Cancer-Associated Fibroblasts/metabolism ; Cells, Cultured ; Gene Expression Regulation, Neoplastic ; Humans ; Immune Checkpoint Proteins/genetics ; Lymphocyte Activation ; Melanoma/genetics ; Skin Neoplasms/genetics ; T-Lymphocytes, Cytotoxic/immunology ; T-Lymphocytes, Cytotoxic/metabolism
Czasopismo naukowe
Tytuł :
Rational design, engineer, and characterization of a novel pegylated single isomer human arginase for arginine depriving anti-cancer treatment.
Autorzy :
Yu KM; Athenex, Inc., Conventus Building, 1001 Main Street, Suite 600, Buffalo, NY, USA. Electronic address: .
Pang TP; Avalon Polytom (HK) Ltd., Unit 1511-13 & 15, Level 15, Tower II, Grand Central Plaza, 138 Shatin Rural Committee Road, Shatin, Hong Kong.
Cutler M; Athenex, Inc., Conventus Building, 1001 Main Street, Suite 600, Buffalo, NY, USA.
Tian M; Athenex, Inc., Conventus Building, 1001 Main Street, Suite 600, Buffalo, NY, USA.
Huang L; Athenex, Inc., Conventus Building, 1001 Main Street, Suite 600, Buffalo, NY, USA.
Lau JY; Athenex, Inc., Conventus Building, 1001 Main Street, Suite 600, Buffalo, NY, USA; State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology and Lo Ka Chung Research Centre for Natural Anti-Cancer Drug, The Hong Kong Polytechnic University, Hong Kong.
Chung SF; State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology and Lo Ka Chung Research Centre for Natural Anti-Cancer Drug, The Hong Kong Polytechnic University, Hong Kong.
Lo TW; State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology and Lo Ka Chung Research Centre for Natural Anti-Cancer Drug, The Hong Kong Polytechnic University, Hong Kong.
Leung TY; State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology and Lo Ka Chung Research Centre for Natural Anti-Cancer Drug, The Hong Kong Polytechnic University, Hong Kong.
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Źródło :
Life sciences [Life Sci] 2021 Jan 01; Vol. 264, pp. 118674. Date of Electronic Publication: 2020 Oct 28.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Design*
Antineoplastic Agents/*chemical synthesis
Arginase/*chemical synthesis
Arginine/*deficiency
Chemical Engineering/*methods
Polyethylene Glycols/*chemical synthesis
Animals ; Antineoplastic Agents/administration & dosage ; Arginase/administration & dosage ; Arginine/antagonists & inhibitors ; Dose-Response Relationship, Drug ; Humans ; Isoenzymes/administration & dosage ; Isoenzymes/chemical synthesis ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Polyethylene Glycols/administration & dosage ; Protein Structure, Secondary ; Rats ; Rats, Sprague-Dawley ; Treatment Outcome ; Xenograft Model Antitumor Assays/methods
Czasopismo naukowe
Tytuł :
Arginase II Plays a Central Role in the Sexual Dimorphism of Arginine Metabolism in C57BL/6 Mice.
Autorzy :
Mohammad MA; USDA/ARS (Agricultural Research Service) Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.; Food Science and Nutrition Department, National Research Centre, Dokki, Giza, Egypt.
Didelija IC; USDA/ARS (Agricultural Research Service) Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Marini JC; USDA/ARS (Agricultural Research Service) Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.; Pediatric Critical Care Medicine, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
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Źródło :
The Journal of nutrition [J Nutr] 2020 Dec 10; Vol. 150 (12), pp. 3133-3140.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Amino Acids/*metabolism
Arginase/*metabolism
Arginine/*metabolism
Gene Expression Regulation, Enzymologic/*drug effects
Amino Acids/pharmacology ; Animals ; Arginase/genetics ; Arginine/blood ; Arginine/pharmacology ; Citrulline/blood ; Citrulline/metabolism ; Female ; Gene Expression Regulation, Enzymologic/physiology ; Genotype ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout
Czasopismo naukowe
Tytuł :
What we know about plant arginases?
Autorzy :
Siddappa S; Department of Studies in Biochemistry, University of Mysore, Manasagangothri, Mysuru, 570006, Karnataka, India.
Marathe GK; Department of Studies in Biochemistry, University of Mysore, Manasagangothri, Mysuru, 570006, Karnataka, India; Department of Studies in Molecular Biology, University of Mysore, Manasagangothri, Mysuru, 570006, Karnataka, India. Electronic address: .
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Źródło :
Plant physiology and biochemistry : PPB [Plant Physiol Biochem] 2020 Nov; Vol. 156, pp. 600-610. Date of Electronic Publication: 2020 Oct 07.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Arginase*
Nitrogen/*metabolism
Plants/*enzymology
Animals ; Arginine ; Urea ; Urease
Czasopismo naukowe
Tytuł :
MS4A4A Regulates Arginase 1 Induction during Macrophage Polarization and Lung Inflammation in Mice.
Autorzy :
Sui Y; Institute for Immunology and School of Medicine, Center for Life Sciences, Tsinghua University, Beijing, China.; Beijing Key Laboratory for Immunological Research on Chronic Diseases, Beijing, China.; School of Life Science, Tsinghua University, Beijing, China.
Zeng W; Institute for Immunology and School of Medicine, Center for Life Sciences, Tsinghua University, Beijing, China.; Beijing Key Laboratory for Immunological Research on Chronic Diseases, Beijing, China.
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Źródło :
European journal of immunology [Eur J Immunol] 2020 Oct; Vol. 50 (10), pp. 1602-1605. Date of Electronic Publication: 2020 Jul 29.
Typ publikacji :
Letter; Research Support, Non-U.S. Gov't
MeSH Terms :
Arginase/*metabolism
Eosinophils/*immunology
Hypersensitivity/*immunology
Lung/*immunology
Macrophages/*physiology
Membrane Proteins/*metabolism
Pneumonia/*immunology
Animals ; Antigens, Dermatophagoides/immunology ; Arginase/genetics ; Cell Differentiation ; Macrophage Activation ; Membrane Proteins/genetics ; Mice ; Mice, Knockout ; Pyroglyphidae ; Up-Regulation
Raport
Tytuł :
Arginase impedes the resolution of colitis by altering the microbiome and metabolome.
Autorzy :
Baier J; Mikrobiologisches Institut, Klinische Mikrobiologie, Immunologie und Hygiene.
Gänsbauer M; Mikrobiologisches Institut, Klinische Mikrobiologie, Immunologie und Hygiene.
Giessler C; Mikrobiologisches Institut, Klinische Mikrobiologie, Immunologie und Hygiene.
Arnold H; Mikrobiologisches Institut, Klinische Mikrobiologie, Immunologie und Hygiene.
Muske M; Mikrobiologisches Institut, Klinische Mikrobiologie, Immunologie und Hygiene.
Schleicher U; Mikrobiologisches Institut, Klinische Mikrobiologie, Immunologie und Hygiene.
Lukassen S; Humangenetisches Institut.
Ekici A; Humangenetisches Institut.
Rauh M; Kinder- und Jugendklinik.
Daniel C; Nephropathologische Abteilung, and.
Hartmann A; Pathologisches Institut, Universitätsklinikum Erlangen and Friedrich-Alexander Universität (FAU) Erlangen-Nürnberg, Erlangen, Germany.
Schmid B; Optical Imaging Centre Erlangen (OICE), FAU Erlangen-Nürnberg, Erlangen, Germany.
Tripal P; Optical Imaging Centre Erlangen (OICE), FAU Erlangen-Nürnberg, Erlangen, Germany.
Dettmer K; Institut für Funktionelle Genomik, Universität Regensburg, Regensburg, Germany.
Oefner PJ; Institut für Funktionelle Genomik, Universität Regensburg, Regensburg, Germany.
Atreya R; Medizinische Klinik 1-Gastroenterologie, Pneumologie and Endokrinologie, Universitätsklinikum Erlangen and FAU Erlangen-Nürnberg, Erlangen, Germany.
Wirtz S; Medizinische Klinik 1-Gastroenterologie, Pneumologie and Endokrinologie, Universitätsklinikum Erlangen and FAU Erlangen-Nürnberg, Erlangen, Germany.; Medical Immunology Campus Erlangen, FAU Erlangen-Nürnberg, Erlangen, Germany.
Bogdan C; Mikrobiologisches Institut, Klinische Mikrobiologie, Immunologie und Hygiene.; Medical Immunology Campus Erlangen, FAU Erlangen-Nürnberg, Erlangen, Germany.
Mattner J; Mikrobiologisches Institut, Klinische Mikrobiologie, Immunologie und Hygiene.; Medical Immunology Campus Erlangen, FAU Erlangen-Nürnberg, Erlangen, Germany.
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Źródło :
The Journal of clinical investigation [J Clin Invest] 2020 Nov 02; Vol. 130 (11), pp. 5703-5720.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gastrointestinal Microbiome*
Hyperargininemia*/genetics
Hyperargininemia*/metabolism
Hyperargininemia*/microbiology
Hyperargininemia*/pathology
Inflammatory Bowel Diseases*/genetics
Inflammatory Bowel Diseases*/metabolism
Inflammatory Bowel Diseases*/microbiology
Inflammatory Bowel Diseases*/pathology
Metabolome*
Arginase/*metabolism
Animals ; Arginase/genetics ; Arginine/genetics ; Arginine/metabolism ; Endothelial Cells/enzymology ; Endothelial Cells/pathology ; Hematopoietic Stem Cells/enzymology ; Hematopoietic Stem Cells/pathology ; Mice ; Mice, Knockout
Czasopismo naukowe
Tytuł :
Myeloid-derived suppressor cells shift Th17/Treg ratio and promote systemic lupus erythematosus progression through arginase-1/miR-322-5p/TGF-β pathway.
Autorzy :
Pang B; Central Laboratory of the Eastern Division, The First Hospital of Jilin University, Changchun, Jilin, China.; Department of Cardiology, The First Hospital of Jilin University, Changchun, Jilin, China.
Zhen Y; Central Laboratory of the Eastern Division, The First Hospital of Jilin University, Changchun, Jilin, China.; Key Laboratory of Organ Regeneration and Transplantation, Ministry of Education, Changchun, Jilin 130021, China.; Department of Dermatology, The First Hospital of Jilin University, Changchun, Jilin, China.
Hu C; Central Laboratory of the Eastern Division, The First Hospital of Jilin University, Changchun, Jilin, China.; Key Laboratory of Organ Regeneration and Transplantation, Ministry of Education, Changchun, Jilin 130021, China.; Center for Reproductive Medicine, Center for Prenatal Diagnosis, The First Hospital of Jilin University, Changchun, Jilin, China.
Ma Z; Central Laboratory of the Eastern Division, The First Hospital of Jilin University, Changchun, Jilin, China.; Key Laboratory of Organ Regeneration and Transplantation, Ministry of Education, Changchun, Jilin 130021, China.
Lin S; Central Laboratory of the Eastern Division, The First Hospital of Jilin University, Changchun, Jilin, China.; Key Laboratory of Organ Regeneration and Transplantation, Ministry of Education, Changchun, Jilin 130021, China.
Yi H; Central Laboratory of the Eastern Division, The First Hospital of Jilin University, Changchun, Jilin, China.; Key Laboratory of Organ Regeneration and Transplantation, Ministry of Education, Changchun, Jilin 130021, China.
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Źródło :
Clinical science (London, England : 1979) [Clin Sci (Lond)] 2020 Aug 28; Vol. 134 (16), pp. 2209-2222.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Arginase/*immunology
Lupus Erythematosus, Systemic/*immunology
MicroRNAs/*immunology
Myeloid-Derived Suppressor Cells/*immunology
T-Lymphocytes, Regulatory/*immunology
Th17 Cells/*immunology
Transforming Growth Factor beta/*immunology
Animals ; Arginase/genetics ; Arginase/metabolism ; Disease Models, Animal ; Disease Progression ; Female ; Gene Expression/genetics ; Gene Expression/immunology ; Humans ; Lupus Erythematosus, Systemic/genetics ; Lupus Erythematosus, Systemic/metabolism ; Mice, Inbred C57BL ; MicroRNAs/genetics ; Myeloid-Derived Suppressor Cells/metabolism ; Signal Transduction/genetics ; Signal Transduction/immunology ; T-Lymphocytes, Regulatory/metabolism ; Th17 Cells/metabolism ; Transforming Growth Factor beta/genetics ; Transforming Growth Factor beta/metabolism
Czasopismo naukowe
Tytuł :
A novel compound heterozygous mutation in the arginase-1 gene identified in a Chinese patient with argininemia: A case report.
Autorzy :
Cui D; Department of Neurology, Qilu Hospital of Shandong University, Jinan, Shandong, People's Republic of China.
Liu Y
Jin L
Hu L
Cao L
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Źródło :
Medicine [Medicine (Baltimore)] 2020 Aug 07; Vol. 99 (32), pp. e21634.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Arginase/*genetics
Hyperargininemia/*complications
Arginase/blood ; Arginase/urine ; Baclofen/therapeutic use ; Botulinum Toxins/therapeutic use ; Cerebral Palsy/complications ; Cerebral Palsy/drug therapy ; Child ; China ; Diet, Protein-Restricted/methods ; Humans ; Hyperargininemia/genetics ; Hyperargininemia/physiopathology ; Male ; Propiophenones/therapeutic use
Czasopismo naukowe
Tytuł :
Mono-PEGylation of a Thermostable Arginine-Depleting Enzyme for the Treatment of Lung Cancer.
Autorzy :
Chung SF; Department of Applied Biology and Chemical Technology, Lo Ka Chung Research Centre for Natural Anti-Cancer Drug Development and State Key Laboratory of Chemical Biology and Drug Discovery, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.
Kim CF; Department of Applied Biology and Chemical Technology, Lo Ka Chung Research Centre for Natural Anti-Cancer Drug Development and State Key Laboratory of Chemical Biology and Drug Discovery, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.
Kwok SY; Department of Applied Biology and Chemical Technology, Lo Ka Chung Research Centre for Natural Anti-Cancer Drug Development and State Key Laboratory of Chemical Biology and Drug Discovery, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.
Tam SY; Department of Applied Biology and Chemical Technology, Lo Ka Chung Research Centre for Natural Anti-Cancer Drug Development and State Key Laboratory of Chemical Biology and Drug Discovery, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.
Chen YW; Department of Applied Biology and Chemical Technology, Lo Ka Chung Research Centre for Natural Anti-Cancer Drug Development and State Key Laboratory of Chemical Biology and Drug Discovery, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.
Chong HC; Department of Applied Biology and Chemical Technology, Lo Ka Chung Research Centre for Natural Anti-Cancer Drug Development and State Key Laboratory of Chemical Biology and Drug Discovery, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.
Leung SL; Department of Applied Biology and Chemical Technology, Lo Ka Chung Research Centre for Natural Anti-Cancer Drug Development and State Key Laboratory of Chemical Biology and Drug Discovery, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.
So PK; Department of Applied Biology and Chemical Technology, Lo Ka Chung Research Centre for Natural Anti-Cancer Drug Development and State Key Laboratory of Chemical Biology and Drug Discovery, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.
Wong KY; Department of Applied Biology and Chemical Technology, Lo Ka Chung Research Centre for Natural Anti-Cancer Drug Development and State Key Laboratory of Chemical Biology and Drug Discovery, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.
Leung YC; Department of Applied Biology and Chemical Technology, Lo Ka Chung Research Centre for Natural Anti-Cancer Drug Development and State Key Laboratory of Chemical Biology and Drug Discovery, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.
Lo WH; Department of Applied Biology and Chemical Technology, Lo Ka Chung Research Centre for Natural Anti-Cancer Drug Development and State Key Laboratory of Chemical Biology and Drug Discovery, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Jun 14; Vol. 21 (12). Date of Electronic Publication: 2020 Jun 14.
Typ publikacji :
Journal Article
MeSH Terms :
Mutation*
Arginase/*pharmacology
Geobacillus/*enzymology
Lung Neoplasms/*drug therapy
A549 Cells ; Animals ; Arginase/chemistry ; Arginase/genetics ; Arginine/metabolism ; Bacterial Proteins/chemistry ; Bacterial Proteins/genetics ; Bacterial Proteins/pharmacology ; Drug Stability ; Geobacillus/genetics ; Half-Life ; Humans ; Hydrolases/administration & dosage ; Hydrolases/pharmacology ; Injections, Intraperitoneal ; Lung Neoplasms/metabolism ; Mice ; Models, Molecular ; Polyethylene Glycols/administration & dosage ; Polyethylene Glycols/chemistry ; Polyethylene Glycols/pharmacology ; Treatment Outcome ; Xenograft Model Antitumor Assays
SCR Organism :
Bacillus caldovelox
Czasopismo naukowe
Tytuł :
Circulating and tumor-infiltrating arginase 1-expressing cells in gastric adenocarcinoma patients were mainly immature and monocytic Myeloid-derived suppressor cells.
Autorzy :
Ren W; Department of Laboratory Medicine, The First Affiliated Hospital of Henan University of Chinese Medicine, No.19 Renmin Road, Zhengzhou, Henan Province, China. .
Zhang X; Department of Laboratory Medicine, The First Affiliated Hospital of Henan University of Chinese Medicine, No.19 Renmin Road, Zhengzhou, Henan Province, China.
Li W; Department of Laboratory Medicine, The First Affiliated Hospital of Henan University of Chinese Medicine, No.19 Renmin Road, Zhengzhou, Henan Province, China.
Feng Q; Department of Laboratory Medicine, The First Affiliated Hospital of Henan University of Chinese Medicine, No.19 Renmin Road, Zhengzhou, Henan Province, China.
Feng H; Department of Laboratory Medicine, The First Affiliated Hospital of Henan University of Chinese Medicine, No.19 Renmin Road, Zhengzhou, Henan Province, China.
Tong Y; Department of Laboratory Medicine, The First Affiliated Hospital of Henan University of Chinese Medicine, No.19 Renmin Road, Zhengzhou, Henan Province, China.
Rong H; Department of Laboratory Medicine, The First Affiliated Hospital of Henan University of Chinese Medicine, No.19 Renmin Road, Zhengzhou, Henan Province, China.
Wang W; Department of Laboratory Medicine, The First Affiliated Hospital of Henan University of Chinese Medicine, No.19 Renmin Road, Zhengzhou, Henan Province, China.
Zhang D; Department of Laboratory Medicine, The First Affiliated Hospital of Henan University of Chinese Medicine, No.19 Renmin Road, Zhengzhou, Henan Province, China.
Zhang Z; Immunology Laboratory of Chinese Medicine, Henan University of Chinese Medicine, No.156 Jinshui East Road, Zhengzhou, Henan Province, China.
Tu S; Neurodegenerative Disease Center, Scintillon Institute, San Diego, CA, 92121, USA.
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Źródło :
Scientific reports [Sci Rep] 2020 May 15; Vol. 10 (1), pp. 8056. Date of Electronic Publication: 2020 May 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adenocarcinoma/*etiology
Adenocarcinoma/*pathology
Arginase/*genetics
Myeloid-Derived Suppressor Cells/*metabolism
Stomach Neoplasms/*etiology
Stomach Neoplasms/*pathology
Adenocarcinoma/metabolism ; Arginase/metabolism ; Gene Expression ; HLA-DR Antigens/immunology ; HLA-DR Antigens/metabolism ; Humans ; Monocytes/immunology ; Monocytes/metabolism ; Myeloid-Derived Suppressor Cells/pathology ; Nitric Oxide Synthase Type II/genetics ; Nitric Oxide Synthase Type II/metabolism ; Stomach Neoplasms/metabolism ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/metabolism
Czasopismo naukowe
Tytuł :
Detection and functional evaluation of arginase-1 isolated from human PMNs and murine MDSC.
Autorzy :
Canè S; Department of Medicine, Section of Immunology, University of Verona, Verona, Italy.
Bronte V; Department of Medicine, Section of Immunology, University of Verona, Verona, Italy. Electronic address: .
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Źródło :
Methods in enzymology [Methods Enzymol] 2020; Vol. 632, pp. 193-213. Date of Electronic Publication: 2019 Aug 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Arginase/*immunology
Myeloid-Derived Suppressor Cells/*immunology
Neutrophils/*immunology
Animals ; Arginase/analysis ; Cell Proliferation ; Cells, Cultured ; Flow Cytometry/methods ; Fluorescent Antibody Technique/methods ; Humans ; Mice ; Neoplasms/immunology ; T-Lymphocytes/immunology ; Tumor Microenvironment
Czasopismo naukowe
Tytuł :
The potential therapeutic effect of adipose-derived mesenchymal stem cells in the treatment of cutaneous leishmaniasis caused by L. major in BALB/c mice.
Autorzy :
Bahrami S; Department of Pathobiology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran. Electronic address: .
Safari M; Department of Pathobiology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
Razi Jalali MH; Department of Pathobiology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
Ghorbanpoor M; Department of Pathobiology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
Tabandeh MR; Department of Basic Science, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
Rezaie A; Department of Pathobiology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
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Źródło :
Experimental parasitology [Exp Parasitol] 2021 Mar; Vol. 222, pp. 108063. Date of Electronic Publication: 2021 Jan 04.
Typ publikacji :
Journal Article
MeSH Terms :
Leishmania major*
Leishmaniasis, Cutaneous/*therapy
Mesenchymal Stem Cells/*immunology
Analysis of Variance ; Animals ; Arginase/genetics ; Arginase/metabolism ; Down-Regulation ; Female ; Forkhead Transcription Factors/genetics ; Forkhead Transcription Factors/metabolism ; Gene Expression ; Interleukin-10/genetics ; Interleukin-10/metabolism ; Interleukin-12/genetics ; Interleukin-12/metabolism ; Interleukin-4/genetics ; Interleukin-4/metabolism ; Mice ; Mice, Inbred BALB C ; Th1 Cells/immunology ; Tumor Necrosis Factor-alpha/genetics ; Tumor Necrosis Factor-alpha/metabolism ; Up-Regulation
Czasopismo naukowe
Tytuł :
Hepatic thermal injury promotes colorectal cancer engraftment in C57/black 6 mice.
Autorzy :
Halpern AL; Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Fitz JG; Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas.
Fujiwara Y; Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Yi J; Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Anderson AL; Section of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Zhu Y; Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Schulick RD; Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
El Kasmi KC; Section of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Barnett CC Jr; Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
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Źródło :
American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2021 Jan 01; Vol. 320 (1), pp. C142-C151. Date of Electronic Publication: 2020 Nov 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Tumor Microenvironment*
Adenocarcinoma/*secondary
Burns, Electric/*pathology
Colonic Neoplasms/*pathology
Liver/*pathology
Liver Neoplasms/*secondary
Adenocarcinoma/metabolism ; Animals ; Arginase/genetics ; Arginase/metabolism ; Burns, Electric/genetics ; Burns, Electric/metabolism ; Cell Line, Tumor ; Colonic Neoplasms/metabolism ; Disease Models, Animal ; Disease Progression ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Liver/metabolism ; Liver Neoplasms/metabolism ; Macrophage Activation ; Mice, Inbred C57BL ; Neoplasm Transplantation ; Signal Transduction ; Vascular Endothelial Growth Factor A/genetics ; Vascular Endothelial Growth Factor A/metabolism
Czasopismo naukowe
Tytuł :
Preclinical safety and antitumor activity of the arginine-degrading therapeutic enzyme pegzilarginase, a PEGylated, cobalt-substituted recombinant human arginase 1.
Autorzy :
Agnello G; Aeglea BioTherapeutics, Inc., Austin, Texas.
Alters SE; Aeglea BioTherapeutics, Inc., Austin, Texas.
Rowlinson SW; Aeglea BioTherapeutics, Inc., Austin, Texas. Electronic address: .
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Źródło :
Translational research : the journal of laboratory and clinical medicine [Transl Res] 2020 Mar; Vol. 217, pp. 11-22. Date of Electronic Publication: 2019 Dec 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*pharmacology
Arginase/*pharmacology
Animals ; Arginase/analysis ; Arginase/toxicity ; Female ; Humans ; Macaca fascicularis ; Male ; Mice ; Mice, Inbred ICR ; Neoplasms, Experimental/drug therapy ; Neoplasms, Experimental/enzymology ; Recombinant Proteins/pharmacology ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
p32-Dependent p38 MAPK Activation by Arginase II Downregulation Contributes to Endothelial Nitric Oxide Synthase Activation in HUVECs.
Autorzy :
Koo BH; Department of Biological Sciences, Kangwon National University, Chuncheon, Gangwon 24341, Korea.
Won MH; Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon, Gangwon 24341, Korea.
Kim YM; Department of Molecular and Cellular Biochemistry, School of Medicine, Kangwon National University, Chuncheon, Gangwon 24341, Korea.
Ryoo S; Department of Biological Sciences, Kangwon National University, Chuncheon, Gangwon 24341, Korea.
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Źródło :
Cells [Cells] 2020 Feb 08; Vol. 9 (2). Date of Electronic Publication: 2020 Feb 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Down-Regulation*/drug effects
Arginase/*genetics
Human Umbilical Vein Endothelial Cells/*metabolism
Mitochondrial Proteins/*metabolism
Nitric Oxide Synthase Type III/*metabolism
p38 Mitogen-Activated Protein Kinases/*metabolism
Animals ; Aorta/metabolism ; Arginase/metabolism ; Calcium/metabolism ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/metabolism ; Cholesterol, Dietary ; Enzyme Activation/drug effects ; Human Umbilical Vein Endothelial Cells/drug effects ; Humans ; Mice, Inbred C57BL ; Nitric Oxide/biosynthesis ; Phosphorylation/drug effects ; Phosphoserine/metabolism ; Protein Kinase Inhibitors/pharmacology ; Proto-Oncogene Proteins c-akt/metabolism ; Reactive Oxygen Species/metabolism ; Vasodilation/drug effects
Czasopismo naukowe
Tytuł :
Arginase promotes immune evasion of Echinococcus granulosus in mice.
Autorzy :
Cao S; National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, 200025, China.; Chinese Center for Tropical Diseases Research, Shanghai, 200025, China.; WHO Collaborating Centre for Tropical Diseases, Shanghai, 200025, China.; National Center for International Research on Tropical Diseases, Ministry of Science and Technology, Shanghai, 200025, China.; Key Laboratory of Parasite and Vector Biology, Ministry of Health, Shanghai, 200025, China.
Gong W; National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, 200025, China.; Chinese Center for Tropical Diseases Research, Shanghai, 200025, China.; WHO Collaborating Centre for Tropical Diseases, Shanghai, 200025, China.; National Center for International Research on Tropical Diseases, Ministry of Science and Technology, Shanghai, 200025, China.; Key Laboratory of Parasite and Vector Biology, Ministry of Health, Shanghai, 200025, China.
Zhang X; National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, 200025, China.; Chinese Center for Tropical Diseases Research, Shanghai, 200025, China.; WHO Collaborating Centre for Tropical Diseases, Shanghai, 200025, China.; National Center for International Research on Tropical Diseases, Ministry of Science and Technology, Shanghai, 200025, China.; Key Laboratory of Parasite and Vector Biology, Ministry of Health, Shanghai, 200025, China.
Xu M; National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, 200025, China.; Chinese Center for Tropical Diseases Research, Shanghai, 200025, China.; WHO Collaborating Centre for Tropical Diseases, Shanghai, 200025, China.; National Center for International Research on Tropical Diseases, Ministry of Science and Technology, Shanghai, 200025, China.; Key Laboratory of Parasite and Vector Biology, Ministry of Health, Shanghai, 200025, China.
Wang Y; National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, 200025, China.; Chinese Center for Tropical Diseases Research, Shanghai, 200025, China.; WHO Collaborating Centre for Tropical Diseases, Shanghai, 200025, China.; National Center for International Research on Tropical Diseases, Ministry of Science and Technology, Shanghai, 200025, China.; Key Laboratory of Parasite and Vector Biology, Ministry of Health, Shanghai, 200025, China.
Xu Y; National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, 200025, China.; Chinese Center for Tropical Diseases Research, Shanghai, 200025, China.; WHO Collaborating Centre for Tropical Diseases, Shanghai, 200025, China.; National Center for International Research on Tropical Diseases, Ministry of Science and Technology, Shanghai, 200025, China.; Key Laboratory of Parasite and Vector Biology, Ministry of Health, Shanghai, 200025, China.
Cao J; National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, 200025, China.; Chinese Center for Tropical Diseases Research, Shanghai, 200025, China.; WHO Collaborating Centre for Tropical Diseases, Shanghai, 200025, China.; National Center for International Research on Tropical Diseases, Ministry of Science and Technology, Shanghai, 200025, China.; Key Laboratory of Parasite and Vector Biology, Ministry of Health, Shanghai, 200025, China.
Shen Y; National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, 200025, China. .; Chinese Center for Tropical Diseases Research, Shanghai, 200025, China. .; WHO Collaborating Centre for Tropical Diseases, Shanghai, 200025, China. .; National Center for International Research on Tropical Diseases, Ministry of Science and Technology, Shanghai, 200025, China. .; Key Laboratory of Parasite and Vector Biology, Ministry of Health, Shanghai, 200025, China. .
Chen J; National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, 200025, China. .; Chinese Center for Tropical Diseases Research, Shanghai, 200025, China. .; WHO Collaborating Centre for Tropical Diseases, Shanghai, 200025, China. .; National Center for International Research on Tropical Diseases, Ministry of Science and Technology, Shanghai, 200025, China. .; Key Laboratory of Parasite and Vector Biology, Ministry of Health, Shanghai, 200025, China. .
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Źródło :
Parasites & vectors [Parasit Vectors] 2020 Feb 06; Vol. 13 (1), pp. 49. Date of Electronic Publication: 2020 Feb 06.
Typ publikacji :
Journal Article
MeSH Terms :
Arginase/*immunology
Echinococcus granulosus/*immunology
Immune Evasion/*physiology
Animals ; Arginase/metabolism ; Echinococcosis/immunology ; Mice ; Mice, Inbred BALB C ; Myeloid Cells/immunology ; Nitric Oxide Synthase Type II/immunology ; Nitric Oxide Synthase Type II/metabolism ; T-Lymphocytes/immunology
Czasopismo naukowe
Tytuł :
Endothelin-1 increases expression and activity of arginase 2 via ETB receptors and is co-expressed with arginase 2 in human atherosclerotic plaques.
Autorzy :
Rafnsson A; From the Department of Medicine, Division of Cardiology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden. Electronic address: .
Matic LP; Division of Vascular Surgery, Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Lengquist M; Division of Vascular Surgery, Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Mahdi A; From the Department of Medicine, Division of Cardiology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Shemyakin A; From the Department of Medicine, Division of Cardiology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Paulsson-Berne G; Division of Cardiovascular Medicine, Center for Molecular Medicine, Department of Medicine. Karolinska Institutet, Stockholm, Sweden.
Hansson GK; Division of Cardiovascular Medicine, Center for Molecular Medicine, Department of Medicine. Karolinska Institutet, Stockholm, Sweden.
Gabrielsen A; From the Department of Medicine, Division of Cardiology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden; Division of Cardiovascular Medicine, Center for Molecular Medicine, Department of Medicine. Karolinska Institutet, Stockholm, Sweden.
Hedin U; Division of Vascular Surgery, Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Yang J; From the Department of Medicine, Division of Cardiology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Pernow J; From the Department of Medicine, Division of Cardiology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
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Źródło :
Atherosclerosis [Atherosclerosis] 2020 Jan; Vol. 292, pp. 215-223. Date of Electronic Publication: 2019 Oct 01.
Typ publikacji :
Journal Article
MeSH Terms :
Arginase/*physiology
Endothelin-1/*physiology
Plaque, Atherosclerotic/*metabolism
Receptor, Endothelin B/*physiology
Arginase/biosynthesis ; Cells, Cultured ; Endothelial Cells ; Endothelin-1/biosynthesis ; Humans
Czasopismo naukowe
Tytuł :
Functional analysis of the Mn requirement in the catalysis of ureohydrolases arginase and agmatinase - a historical perspective.
Autorzy :
Uribe E; Departamento de Bioquímica y Biología Molecular, Facultad de Ciencias Biológicas, Universidad de Concepción, Casilla 160-C, Concepción, Chile. Electronic address: .
Reyes MB; Departamento de Bioquímica y Biología Molecular, Facultad de Ciencias Biológicas, Universidad de Concepción, Casilla 160-C, Concepción, Chile.
Martínez I; Departamento de Bioquímica y Biología Molecular, Facultad de Ciencias Biológicas, Universidad de Concepción, Casilla 160-C, Concepción, Chile.
Mella K; Departamento de Bioquímica y Biología Molecular, Facultad de Ciencias Biológicas, Universidad de Concepción, Casilla 160-C, Concepción, Chile.
Salas M; Instituto de Bioquímica y Microbiología, Universidad Austral de Chile, Valdivia, Chile.
Tarifeño-Saldivia E; Departamento de Bioquímica y Biología Molecular, Facultad de Ciencias Biológicas, Universidad de Concepción, Casilla 160-C, Concepción, Chile.
López V; Departamento de Ciencias Biomédicas. Universidad Católica del Norte, Coquimbo, Chile.
García-Robles M; Departamento de Biología Celular, Facultad de Ciencias Biológicas, Universidad de Concepción, Casilla 160-C, Concepción, Chile.
Martínez-Oyanedel J; Departamento de Bioquímica y Biología Molecular, Facultad de Ciencias Biológicas, Universidad de Concepción, Casilla 160-C, Concepción, Chile.
Figueroa M; Departamento de Bioquímica y Biología Molecular, Facultad de Ciencias Biológicas, Universidad de Concepción, Casilla 160-C, Concepción, Chile.
Carvajal N; Departamento de Bioquímica y Biología Molecular, Facultad de Ciencias Biológicas, Universidad de Concepción, Casilla 160-C, Concepción, Chile.
Schenk G; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia.
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Źródło :
Journal of inorganic biochemistry [J Inorg Biochem] 2020 Jan; Vol. 202, pp. 110812. Date of Electronic Publication: 2019 Aug 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Arginase*/chemistry
Arginase*/metabolism
Manganese*/chemistry
Manganese*/metabolism
Ureohydrolases*/chemistry
Ureohydrolases*/metabolism
Catalysis
Czasopismo naukowe
Tytuł :
Co-stimulation with opposing macrophage polarization cues leads to orthogonal secretion programs in individual cells.
Autorzy :
Muñoz-Rojas AR; Department of Biomedical Engineering, Yale University, New Haven, CT, USA.; Department of Immunology, Harvard Medical School, Boston, MA, USA.
Kelsey I; Department of Biomedical Engineering, Yale University, New Haven, CT, USA.
Pappalardo JL; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
Chen M; Department of Biomedical Engineering, Yale University, New Haven, CT, USA.
Miller-Jensen K; Department of Biomedical Engineering, Yale University, New Haven, CT, USA. .; Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT, USA. .; Systems Biology Institute, Yale University, New Haven, CT, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Jan 12; Vol. 12 (1), pp. 301. Date of Electronic Publication: 2021 Jan 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Cell Polarity*/drug effects
Cell Polarity*/genetics
Macrophages/*cytology
Animals ; Arginase/metabolism ; Female ; Gene Expression Regulation/drug effects ; Interferon-gamma/pharmacology ; Interleukin-12/metabolism ; Interleukin-6/metabolism ; Lipopolysaccharides/pharmacology ; Machine Learning ; Macrophages/drug effects ; Macrophages/metabolism ; Male ; Mice, Inbred C57BL ; Neural Networks, Computer ; Odds Ratio ; Single-Cell Analysis ; Transcription Factors/metabolism ; Transcription, Genetic/drug effects
Czasopismo naukowe
Tytuł :
Cytochrome P450 1A1 enhances Arginase-1 expression, which reduces LPS-induced mouse peritonitis by targeting JAK1/STAT6.
Autorzy :
Tian LX; State Key Laboratory of Trauma, Burns and Combined Injury, Department of Wound Infection and Drug, Daping Hospital, Army Medical University, Chongqing, China.
Tang X; State Key Laboratory of Trauma, Burns and Combined Injury, Department of Wound Infection and Drug, Daping Hospital, Army Medical University, Chongqing, China.
Zhu JY; State Key Laboratory of Trauma, Burns and Combined Injury, Department of Wound Infection and Drug, Daping Hospital, Army Medical University, Chongqing, China.
Zhang W; Emergency and Trauma College of Hainan Medical University, Xueyuan Road 3, Haikou, China.
Tang WQ; State Key Laboratory of Trauma, Burns and Combined Injury, Department of Wound Infection and Drug, Daping Hospital, Army Medical University, Chongqing, China.
Yan J; State Key Laboratory of Trauma, Burns and Combined Injury, Department of Wound Infection and Drug, Daping Hospital, Army Medical University, Chongqing, China.
Xu X; State Key Laboratory of Trauma, Burns and Combined Injury, Department of Wound Infection and Drug, Daping Hospital, Army Medical University, Chongqing, China.
Liang HP; State Key Laboratory of Trauma, Burns and Combined Injury, Department of Wound Infection and Drug, Daping Hospital, Army Medical University, Chongqing, China. Electronic address: .
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Źródło :
Cellular immunology [Cell Immunol] 2020 Mar; Vol. 349, pp. 104047. Date of Electronic Publication: 2020 Jan 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Arginase/*biosynthesis
Cytochrome P-450 CYP1A1/*physiology
Janus Kinase 1/*antagonists & inhibitors
Macrophages, Peritoneal/*drug effects
Peritonitis/*prevention & control
STAT6 Transcription Factor/*antagonists & inhibitors
Signal Transduction/*drug effects
12-Hydroxy-5,8,10,14-eicosatetraenoic Acid/pharmacology ; Adoptive Transfer ; Animals ; Arachidonate 15-Lipoxygenase/physiology ; Arginase/genetics ; Cytochrome P-450 CYP1A1/biosynthesis ; Cytochrome P-450 CYP1A1/genetics ; Endotoxins/toxicity ; Humans ; Hydroxyeicosatetraenoic Acids/biosynthesis ; Hydroxyeicosatetraenoic Acids/genetics ; Hydroxyeicosatetraenoic Acids/pharmacology ; Interleukin-4/pharmacology ; Leukocytes, Mononuclear/drug effects ; Leukocytes, Mononuclear/metabolism ; Leukocytes, Mononuclear/transplantation ; Macrophages, Peritoneal/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Peritonitis/chemically induced ; RAW 264.7 Cells ; RNA Interference ; RNA, Messenger/biosynthesis ; RNA, Messenger/genetics ; Receptors, Cytoplasmic and Nuclear/biosynthesis ; Receptors, Cytoplasmic and Nuclear/genetics ; THP-1 Cells ; Up-Regulation/drug effects
Czasopismo naukowe

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