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Wyszukujesz frazę ""Arterial hypertension"" wg kryterium: Temat


Tytuł :
The soluble guanylate cyclase stimulator, 1-nitro-2-phenylethane, reverses monocrotaline-induced pulmonary arterial hypertension in rats.
Autorzy :
Gonzaga-Costa K; Department of Physiology and Pharmacology, School of Medicine, Federal University of Ceará, CE, Brazil.
Roque CR; Department of Physiology and Pharmacology, School of Medicine, Federal University of Ceará, CE, Brazil.
Vasconcelos-Silva AA; Department of Physiology and Pharmacology, School of Medicine, Federal University of Ceará, CE, Brazil.
Sousa-Brito HL; Department of Physiology and Pharmacology, School of Medicine, Federal University of Ceará, CE, Brazil.
Martins CS; Department of Morphology, Lab Nempi, School of Medicine, Federal University of Ceará, CE, Brazil.
Caetano-Souza MM; VETER, Veterinary Diagnostic Center, Fortaleza, CE, Brazil.
Duarte GP; Department of Physiology and Pharmacology, Federal University of Pernambuco, Recife, PE, Brazil.
da Silva JKR; Faculty of Biotechology, Institute of Biological Sciences, federal University of Pará, Belém, PA, Brazil.
Borges RS; Department of Pharmacy, Federal University of Pará, Belém, PA, Brazil.
Dos Santos AA; Department of Physiology and Pharmacology, School of Medicine, Federal University of Ceará, CE, Brazil.
Magalhães PJC; Department of Physiology and Pharmacology, School of Medicine, Federal University of Ceará, CE, Brazil.
Lahlou S; Department of Physiology and Pharmacology, School of Medicine, Federal University of Ceará, CE, Brazil. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Jun 15; Vol. 275, pp. 119334. Date of Electronic Publication: 2021 Mar 09.
Typ publikacji :
Journal Article
MeSH Terms :
Benzene Derivatives/*pharmacology
Pulmonary Arterial Hypertension/*drug therapy
Animals ; Echocardiography ; Endothelium, Vascular/drug effects ; Hemodynamics/drug effects ; Male ; Monocrotaline/antagonists & inhibitors ; Monocrotaline/pharmacology ; Pulmonary Arterial Hypertension/chemically induced ; Pulmonary Arterial Hypertension/diagnostic imaging ; Pulmonary Artery/drug effects ; Rats ; Rats, Wistar ; Soluble Guanylyl Cyclase/drug effects ; Vascular Remodeling/drug effects
Czasopismo naukowe
Tytuł :
Matrix stiffening induces a pathogenic QKI-miR-7-SRSF1 signaling axis in pulmonary arterial endothelial cells.
Autorzy :
Woodcock CC; Division of Cardiology, Department of Medicine, Center for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Hafeez N; Division of Cardiology, Department of Medicine, Center for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.; Physician Scientist Training Program, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Handen A; Division of Cardiology, Department of Medicine, Center for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Tang Y; Division of Cardiology, Department of Medicine, Center for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Harvey LD; Division of Cardiology, Department of Medicine, Center for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Estephan LE; Division of Cardiology, Department of Medicine, Center for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Speyer G; Research Computing, Arizona State University, Tempe, Arizona.
Kim S; Department of Electrical and Computer Engineering, Center for Computational Systems Biology, Prairie View A&M University, Prairie View, Texas.
Bertero T; Université Côte d'Azur, CNRS, IPMC, Sophia-Antipolis, France.
Chan SY; Division of Cardiology, Department of Medicine, Center for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
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Źródło :
American journal of physiology. Lung cellular and molecular physiology [Am J Physiol Lung Cell Mol Physiol] 2021 May 01; Vol. 320 (5), pp. L726-L738. Date of Electronic Publication: 2021 Feb 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Endothelium, Vascular/*pathology
Extracellular Matrix/*pathology
MicroRNAs/*genetics
Pulmonary Arterial Hypertension/*pathology
Pulmonary Artery/*pathology
RNA-Binding Proteins/*metabolism
Serine-Arginine Splicing Factors/*metabolism
Animals ; Cell Proliferation ; Disease Models, Animal ; Endothelium, Vascular/metabolism ; Extracellular Matrix/metabolism ; Humans ; Male ; Middle Aged ; Pulmonary Arterial Hypertension/genetics ; Pulmonary Arterial Hypertension/metabolism ; Pulmonary Artery/metabolism ; RNA-Binding Proteins/genetics ; Rats ; Rats, Sprague-Dawley ; Serine-Arginine Splicing Factors/genetics ; Signal Transduction ; Vascular Remodeling
Czasopismo naukowe
Tytuł :
A novel unidirectional-valved shunt approach for end-stage pulmonary arterial hypertension: Early experience in adolescents and adults.
Autorzy :
Rosenzweig EB; Division of Pediatric Cardiology, Department of Pediatrics and Medicine, Columbia University Medical Center-New York Presbyterian Hospital, New York, NY. Electronic address: .
Ankola A; Division of Pediatric Cardiology, Department of Pediatrics, Columbia University Medical Center-New York Presbyterian Hospital, New York, NY.
Krishnan U; Division of Pediatric Cardiology, Department of Pediatrics, Columbia University Medical Center-New York Presbyterian Hospital, New York, NY.
Middlesworth W; Division of Pediatric Surgery, Department of Surgery, Columbia University Medical Center-New York Presbyterian Hospital, New York, NY.
Bacha E; Division of Cardiothoracic Surgery, Department of Surgery, Columbia University Medical Center-New York Presbyterian Hospital, New York, NY.
Bacchetta M; Departments of Thoracic & Cardiac Surgery, Vanderbilt University Medical Center, Nashville, Tenn; Department of Biomedical Engineering, Columbia University, New York, NY. Electronic address: .
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Źródło :
The Journal of thoracic and cardiovascular surgery [J Thorac Cardiovasc Surg] 2021 Apr; Vol. 161 (4), pp. 1438-1446.e2. Date of Electronic Publication: 2019 Nov 14.
Typ publikacji :
Journal Article
MeSH Terms :
Blalock-Taussig Procedure/*methods
Pulmonary Arterial Hypertension/*surgery
Adolescent ; Age Factors ; Child ; Echocardiography ; Female ; Humans ; Male ; Pulmonary Arterial Hypertension/diagnostic imaging ; Pulmonary Arterial Hypertension/physiopathology ; Retrospective Studies ; Time Factors ; Treatment Outcome ; Ventricular Function, Right ; Young Adult
Czasopismo naukowe
Tytuł :
Sotatercept for the Treatment of Pulmonary Arterial Hypertension.
Autorzy :
Humbert M; From the Department of Respiratory and Intensive Care Medicine, Hôpital Bicêtre, Assistance Publique-Hôpitaux de Paris, INSERM Unité Mixte de Recherche 999, Université Paris-Saclay, Le Kremlin-Bicêtre, France (M.H., D.M.); the Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor (V.M.); the National Heart and Lung Institute, Imperial College London, and the National Pulmonary Hypertension Service, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London (J.S.R.G.); the Department of Medicine, George Washington University, Washington, DC (M.G.-M.); the Department of Respiratory Medicine, Hannover Medical School, and the German Center for Lung Research - both in Hannover, Germany (M.M.H., K.M.O.); the Division of Pulmonary, Critical Care and Sleep Medicine, Tufts Medical Center (I.R.P.), and the Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital (A.W.), Boston, and Acceleron Pharma, Cambridge (S.M., J.B., P.G.L., J.O.P.) - all in Massachusetts; the Pulmonary Division-Heart Institute, University of São Paulo Medical School, São Paulo (R.S.), and Complexo Hospitalar Santa Casa de Porto Alegre, Pulmonary Vascular Research Institute, Porto Alegre (G.M.) - both in Brazil; the Department of Cardiology, Centro de Investigación en Red en Enfermedades Cardiovasculares, Hospital Universitario 12 de Octubre, Universidad Complutense, Madrid (P.E.S.); Arizona Pulmonary Specialists, Phoenix (J.F.); and the Divisions of Pulmonary Sciences and Critical Care Medicine, and Cardiology, University of Colorado, Anschutz Medical Campus, Aurora (D.B.B.).
McLaughlin V; From the Department of Respiratory and Intensive Care Medicine, Hôpital Bicêtre, Assistance Publique-Hôpitaux de Paris, INSERM Unité Mixte de Recherche 999, Université Paris-Saclay, Le Kremlin-Bicêtre, France (M.H., D.M.); the Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor (V.M.); the National Heart and Lung Institute, Imperial College London, and the National Pulmonary Hypertension Service, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London (J.S.R.G.); the Department of Medicine, George Washington University, Washington, DC (M.G.-M.); the Department of Respiratory Medicine, Hannover Medical School, and the German Center for Lung Research - both in Hannover, Germany (M.M.H., K.M.O.); the Division of Pulmonary, Critical Care and Sleep Medicine, Tufts Medical Center (I.R.P.), and the Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital (A.W.), Boston, and Acceleron Pharma, Cambridge (S.M., J.B., P.G.L., J.O.P.) - all in Massachusetts; the Pulmonary Division-Heart Institute, University of São Paulo Medical School, São Paulo (R.S.), and Complexo Hospitalar Santa Casa de Porto Alegre, Pulmonary Vascular Research Institute, Porto Alegre (G.M.) - both in Brazil; the Department of Cardiology, Centro de Investigación en Red en Enfermedades Cardiovasculares, Hospital Universitario 12 de Octubre, Universidad Complutense, Madrid (P.E.S.); Arizona Pulmonary Specialists, Phoenix (J.F.); and the Divisions of Pulmonary Sciences and Critical Care Medicine, and Cardiology, University of Colorado, Anschutz Medical Campus, Aurora (D.B.B.).
Gibbs JSR; From the Department of Respiratory and Intensive Care Medicine, Hôpital Bicêtre, Assistance Publique-Hôpitaux de Paris, INSERM Unité Mixte de Recherche 999, Université Paris-Saclay, Le Kremlin-Bicêtre, France (M.H., D.M.); the Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor (V.M.); the National Heart and Lung Institute, Imperial College London, and the National Pulmonary Hypertension Service, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London (J.S.R.G.); the Department of Medicine, George Washington University, Washington, DC (M.G.-M.); the Department of Respiratory Medicine, Hannover Medical School, and the German Center for Lung Research - both in Hannover, Germany (M.M.H., K.M.O.); the Division of Pulmonary, Critical Care and Sleep Medicine, Tufts Medical Center (I.R.P.), and the Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital (A.W.), Boston, and Acceleron Pharma, Cambridge (S.M., J.B., P.G.L., J.O.P.) - all in Massachusetts; the Pulmonary Division-Heart Institute, University of São Paulo Medical School, São Paulo (R.S.), and Complexo Hospitalar Santa Casa de Porto Alegre, Pulmonary Vascular Research Institute, Porto Alegre (G.M.) - both in Brazil; the Department of Cardiology, Centro de Investigación en Red en Enfermedades Cardiovasculares, Hospital Universitario 12 de Octubre, Universidad Complutense, Madrid (P.E.S.); Arizona Pulmonary Specialists, Phoenix (J.F.); and the Divisions of Pulmonary Sciences and Critical Care Medicine, and Cardiology, University of Colorado, Anschutz Medical Campus, Aurora (D.B.B.).
Gomberg-Maitland M; From the Department of Respiratory and Intensive Care Medicine, Hôpital Bicêtre, Assistance Publique-Hôpitaux de Paris, INSERM Unité Mixte de Recherche 999, Université Paris-Saclay, Le Kremlin-Bicêtre, France (M.H., D.M.); the Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor (V.M.); the National Heart and Lung Institute, Imperial College London, and the National Pulmonary Hypertension Service, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London (J.S.R.G.); the Department of Medicine, George Washington University, Washington, DC (M.G.-M.); the Department of Respiratory Medicine, Hannover Medical School, and the German Center for Lung Research - both in Hannover, Germany (M.M.H., K.M.O.); the Division of Pulmonary, Critical Care and Sleep Medicine, Tufts Medical Center (I.R.P.), and the Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital (A.W.), Boston, and Acceleron Pharma, Cambridge (S.M., J.B., P.G.L., J.O.P.) - all in Massachusetts; the Pulmonary Division-Heart Institute, University of São Paulo Medical School, São Paulo (R.S.), and Complexo Hospitalar Santa Casa de Porto Alegre, Pulmonary Vascular Research Institute, Porto Alegre (G.M.) - both in Brazil; the Department of Cardiology, Centro de Investigación en Red en Enfermedades Cardiovasculares, Hospital Universitario 12 de Octubre, Universidad Complutense, Madrid (P.E.S.); Arizona Pulmonary Specialists, Phoenix (J.F.); and the Divisions of Pulmonary Sciences and Critical Care Medicine, and Cardiology, University of Colorado, Anschutz Medical Campus, Aurora (D.B.B.).
Hoeper MM; From the Department of Respiratory and Intensive Care Medicine, Hôpital Bicêtre, Assistance Publique-Hôpitaux de Paris, INSERM Unité Mixte de Recherche 999, Université Paris-Saclay, Le Kremlin-Bicêtre, France (M.H., D.M.); the Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor (V.M.); the National Heart and Lung Institute, Imperial College London, and the National Pulmonary Hypertension Service, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London (J.S.R.G.); the Department of Medicine, George Washington University, Washington, DC (M.G.-M.); the Department of Respiratory Medicine, Hannover Medical School, and the German Center for Lung Research - both in Hannover, Germany (M.M.H., K.M.O.); the Division of Pulmonary, Critical Care and Sleep Medicine, Tufts Medical Center (I.R.P.), and the Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital (A.W.), Boston, and Acceleron Pharma, Cambridge (S.M., J.B., P.G.L., J.O.P.) - all in Massachusetts; the Pulmonary Division-Heart Institute, University of São Paulo Medical School, São Paulo (R.S.), and Complexo Hospitalar Santa Casa de Porto Alegre, Pulmonary Vascular Research Institute, Porto Alegre (G.M.) - both in Brazil; the Department of Cardiology, Centro de Investigación en Red en Enfermedades Cardiovasculares, Hospital Universitario 12 de Octubre, Universidad Complutense, Madrid (P.E.S.); Arizona Pulmonary Specialists, Phoenix (J.F.); and the Divisions of Pulmonary Sciences and Critical Care Medicine, and Cardiology, University of Colorado, Anschutz Medical Campus, Aurora (D.B.B.).
Preston IR; From the Department of Respiratory and Intensive Care Medicine, Hôpital Bicêtre, Assistance Publique-Hôpitaux de Paris, INSERM Unité Mixte de Recherche 999, Université Paris-Saclay, Le Kremlin-Bicêtre, France (M.H., D.M.); the Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor (V.M.); the National Heart and Lung Institute, Imperial College London, and the National Pulmonary Hypertension Service, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London (J.S.R.G.); the Department of Medicine, George Washington University, Washington, DC (M.G.-M.); the Department of Respiratory Medicine, Hannover Medical School, and the German Center for Lung Research - both in Hannover, Germany (M.M.H., K.M.O.); the Division of Pulmonary, Critical Care and Sleep Medicine, Tufts Medical Center (I.R.P.), and the Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital (A.W.), Boston, and Acceleron Pharma, Cambridge (S.M., J.B., P.G.L., J.O.P.) - all in Massachusetts; the Pulmonary Division-Heart Institute, University of São Paulo Medical School, São Paulo (R.S.), and Complexo Hospitalar Santa Casa de Porto Alegre, Pulmonary Vascular Research Institute, Porto Alegre (G.M.) - both in Brazil; the Department of Cardiology, Centro de Investigación en Red en Enfermedades Cardiovasculares, Hospital Universitario 12 de Octubre, Universidad Complutense, Madrid (P.E.S.); Arizona Pulmonary Specialists, Phoenix (J.F.); and the Divisions of Pulmonary Sciences and Critical Care Medicine, and Cardiology, University of Colorado, Anschutz Medical Campus, Aurora (D.B.B.).
Souza R; From the Department of Respiratory and Intensive Care Medicine, Hôpital Bicêtre, Assistance Publique-Hôpitaux de Paris, INSERM Unité Mixte de Recherche 999, Université Paris-Saclay, Le Kremlin-Bicêtre, France (M.H., D.M.); the Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor (V.M.); the National Heart and Lung Institute, Imperial College London, and the National Pulmonary Hypertension Service, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London (J.S.R.G.); the Department of Medicine, George Washington University, Washington, DC (M.G.-M.); the Department of Respiratory Medicine, Hannover Medical School, and the German Center for Lung Research - both in Hannover, Germany (M.M.H., K.M.O.); the Division of Pulmonary, Critical Care and Sleep Medicine, Tufts Medical Center (I.R.P.), and the Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital (A.W.), Boston, and Acceleron Pharma, Cambridge (S.M., J.B., P.G.L., J.O.P.) - all in Massachusetts; the Pulmonary Division-Heart Institute, University of São Paulo Medical School, São Paulo (R.S.), and Complexo Hospitalar Santa Casa de Porto Alegre, Pulmonary Vascular Research Institute, Porto Alegre (G.M.) - both in Brazil; the Department of Cardiology, Centro de Investigación en Red en Enfermedades Cardiovasculares, Hospital Universitario 12 de Octubre, Universidad Complutense, Madrid (P.E.S.); Arizona Pulmonary Specialists, Phoenix (J.F.); and the Divisions of Pulmonary Sciences and Critical Care Medicine, and Cardiology, University of Colorado, Anschutz Medical Campus, Aurora (D.B.B.).
Waxman A; From the Department of Respiratory and Intensive Care Medicine, Hôpital Bicêtre, Assistance Publique-Hôpitaux de Paris, INSERM Unité Mixte de Recherche 999, Université Paris-Saclay, Le Kremlin-Bicêtre, France (M.H., D.M.); the Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor (V.M.); the National Heart and Lung Institute, Imperial College London, and the National Pulmonary Hypertension Service, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London (J.S.R.G.); the Department of Medicine, George Washington University, Washington, DC (M.G.-M.); the Department of Respiratory Medicine, Hannover Medical School, and the German Center for Lung Research - both in Hannover, Germany (M.M.H., K.M.O.); the Division of Pulmonary, Critical Care and Sleep Medicine, Tufts Medical Center (I.R.P.), and the Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital (A.W.), Boston, and Acceleron Pharma, Cambridge (S.M., J.B., P.G.L., J.O.P.) - all in Massachusetts; the Pulmonary Division-Heart Institute, University of São Paulo Medical School, São Paulo (R.S.), and Complexo Hospitalar Santa Casa de Porto Alegre, Pulmonary Vascular Research Institute, Porto Alegre (G.M.) - both in Brazil; the Department of Cardiology, Centro de Investigación en Red en Enfermedades Cardiovasculares, Hospital Universitario 12 de Octubre, Universidad Complutense, Madrid (P.E.S.); Arizona Pulmonary Specialists, Phoenix (J.F.); and the Divisions of Pulmonary Sciences and Critical Care Medicine, and Cardiology, University of Colorado, Anschutz Medical Campus, Aurora (D.B.B.).
Escribano Subias P; From the Department of Respiratory and Intensive Care Medicine, Hôpital Bicêtre, Assistance Publique-Hôpitaux de Paris, INSERM Unité Mixte de Recherche 999, Université Paris-Saclay, Le Kremlin-Bicêtre, France (M.H., D.M.); the Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor (V.M.); the National Heart and Lung Institute, Imperial College London, and the National Pulmonary Hypertension Service, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London (J.S.R.G.); the Department of Medicine, George Washington University, Washington, DC (M.G.-M.); the Department of Respiratory Medicine, Hannover Medical School, and the German Center for Lung Research - both in Hannover, Germany (M.M.H., K.M.O.); the Division of Pulmonary, Critical Care and Sleep Medicine, Tufts Medical Center (I.R.P.), and the Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital (A.W.), Boston, and Acceleron Pharma, Cambridge (S.M., J.B., P.G.L., J.O.P.) - all in Massachusetts; the Pulmonary Division-Heart Institute, University of São Paulo Medical School, São Paulo (R.S.), and Complexo Hospitalar Santa Casa de Porto Alegre, Pulmonary Vascular Research Institute, Porto Alegre (G.M.) - both in Brazil; the Department of Cardiology, Centro de Investigación en Red en Enfermedades Cardiovasculares, Hospital Universitario 12 de Octubre, Universidad Complutense, Madrid (P.E.S.); Arizona Pulmonary Specialists, Phoenix (J.F.); and the Divisions of Pulmonary Sciences and Critical Care Medicine, and Cardiology, University of Colorado, Anschutz Medical Campus, Aurora (D.B.B.).
Feldman J; From the Department of Respiratory and Intensive Care Medicine, Hôpital Bicêtre, Assistance Publique-Hôpitaux de Paris, INSERM Unité Mixte de Recherche 999, Université Paris-Saclay, Le Kremlin-Bicêtre, France (M.H., D.M.); the Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor (V.M.); the National Heart and Lung Institute, Imperial College London, and the National Pulmonary Hypertension Service, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London (J.S.R.G.); the Department of Medicine, George Washington University, Washington, DC (M.G.-M.); the Department of Respiratory Medicine, Hannover Medical School, and the German Center for Lung Research - both in Hannover, Germany (M.M.H., K.M.O.); the Division of Pulmonary, Critical Care and Sleep Medicine, Tufts Medical Center (I.R.P.), and the Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital (A.W.), Boston, and Acceleron Pharma, Cambridge (S.M., J.B., P.G.L., J.O.P.) - all in Massachusetts; the Pulmonary Division-Heart Institute, University of São Paulo Medical School, São Paulo (R.S.), and Complexo Hospitalar Santa Casa de Porto Alegre, Pulmonary Vascular Research Institute, Porto Alegre (G.M.) - both in Brazil; the Department of Cardiology, Centro de Investigación en Red en Enfermedades Cardiovasculares, Hospital Universitario 12 de Octubre, Universidad Complutense, Madrid (P.E.S.); Arizona Pulmonary Specialists, Phoenix (J.F.); and the Divisions of Pulmonary Sciences and Critical Care Medicine, and Cardiology, University of Colorado, Anschutz Medical Campus, Aurora (D.B.B.).
Meyer G; From the Department of Respiratory and Intensive Care Medicine, Hôpital Bicêtre, Assistance Publique-Hôpitaux de Paris, INSERM Unité Mixte de Recherche 999, Université Paris-Saclay, Le Kremlin-Bicêtre, France (M.H., D.M.); the Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor (V.M.); the National Heart and Lung Institute, Imperial College London, and the National Pulmonary Hypertension Service, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London (J.S.R.G.); the Department of Medicine, George Washington University, Washington, DC (M.G.-M.); the Department of Respiratory Medicine, Hannover Medical School, and the German Center for Lung Research - both in Hannover, Germany (M.M.H., K.M.O.); the Division of Pulmonary, Critical Care and Sleep Medicine, Tufts Medical Center (I.R.P.), and the Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital (A.W.), Boston, and Acceleron Pharma, Cambridge (S.M., J.B., P.G.L., J.O.P.) - all in Massachusetts; the Pulmonary Division-Heart Institute, University of São Paulo Medical School, São Paulo (R.S.), and Complexo Hospitalar Santa Casa de Porto Alegre, Pulmonary Vascular Research Institute, Porto Alegre (G.M.) - both in Brazil; the Department of Cardiology, Centro de Investigación en Red en Enfermedades Cardiovasculares, Hospital Universitario 12 de Octubre, Universidad Complutense, Madrid (P.E.S.); Arizona Pulmonary Specialists, Phoenix (J.F.); and the Divisions of Pulmonary Sciences and Critical Care Medicine, and Cardiology, University of Colorado, Anschutz Medical Campus, Aurora (D.B.B.).
Montani D; From the Department of Respiratory and Intensive Care Medicine, Hôpital Bicêtre, Assistance Publique-Hôpitaux de Paris, INSERM Unité Mixte de Recherche 999, Université Paris-Saclay, Le Kremlin-Bicêtre, France (M.H., D.M.); the Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor (V.M.); the National Heart and Lung Institute, Imperial College London, and the National Pulmonary Hypertension Service, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London (J.S.R.G.); the Department of Medicine, George Washington University, Washington, DC (M.G.-M.); the Department of Respiratory Medicine, Hannover Medical School, and the German Center for Lung Research - both in Hannover, Germany (M.M.H., K.M.O.); the Division of Pulmonary, Critical Care and Sleep Medicine, Tufts Medical Center (I.R.P.), and the Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital (A.W.), Boston, and Acceleron Pharma, Cambridge (S.M., J.B., P.G.L., J.O.P.) - all in Massachusetts; the Pulmonary Division-Heart Institute, University of São Paulo Medical School, São Paulo (R.S.), and Complexo Hospitalar Santa Casa de Porto Alegre, Pulmonary Vascular Research Institute, Porto Alegre (G.M.) - both in Brazil; the Department of Cardiology, Centro de Investigación en Red en Enfermedades Cardiovasculares, Hospital Universitario 12 de Octubre, Universidad Complutense, Madrid (P.E.S.); Arizona Pulmonary Specialists, Phoenix (J.F.); and the Divisions of Pulmonary Sciences and Critical Care Medicine, and Cardiology, University of Colorado, Anschutz Medical Campus, Aurora (D.B.B.).
Olsson KM; From the Department of Respiratory and Intensive Care Medicine, Hôpital Bicêtre, Assistance Publique-Hôpitaux de Paris, INSERM Unité Mixte de Recherche 999, Université Paris-Saclay, Le Kremlin-Bicêtre, France (M.H., D.M.); the Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor (V.M.); the National Heart and Lung Institute, Imperial College London, and the National Pulmonary Hypertension Service, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London (J.S.R.G.); the Department of Medicine, George Washington University, Washington, DC (M.G.-M.); the Department of Respiratory Medicine, Hannover Medical School, and the German Center for Lung Research - both in Hannover, Germany (M.M.H., K.M.O.); the Division of Pulmonary, Critical Care and Sleep Medicine, Tufts Medical Center (I.R.P.), and the Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital (A.W.), Boston, and Acceleron Pharma, Cambridge (S.M., J.B., P.G.L., J.O.P.) - all in Massachusetts; the Pulmonary Division-Heart Institute, University of São Paulo Medical School, São Paulo (R.S.), and Complexo Hospitalar Santa Casa de Porto Alegre, Pulmonary Vascular Research Institute, Porto Alegre (G.M.) - both in Brazil; the Department of Cardiology, Centro de Investigación en Red en Enfermedades Cardiovasculares, Hospital Universitario 12 de Octubre, Universidad Complutense, Madrid (P.E.S.); Arizona Pulmonary Specialists, Phoenix (J.F.); and the Divisions of Pulmonary Sciences and Critical Care Medicine, and Cardiology, University of Colorado, Anschutz Medical Campus, Aurora (D.B.B.).
Manimaran S; From the Department of Respiratory and Intensive Care Medicine, Hôpital Bicêtre, Assistance Publique-Hôpitaux de Paris, INSERM Unité Mixte de Recherche 999, Université Paris-Saclay, Le Kremlin-Bicêtre, France (M.H., D.M.); the Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor (V.M.); the National Heart and Lung Institute, Imperial College London, and the National Pulmonary Hypertension Service, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London (J.S.R.G.); the Department of Medicine, George Washington University, Washington, DC (M.G.-M.); the Department of Respiratory Medicine, Hannover Medical School, and the German Center for Lung Research - both in Hannover, Germany (M.M.H., K.M.O.); the Division of Pulmonary, Critical Care and Sleep Medicine, Tufts Medical Center (I.R.P.), and the Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital (A.W.), Boston, and Acceleron Pharma, Cambridge (S.M., J.B., P.G.L., J.O.P.) - all in Massachusetts; the Pulmonary Division-Heart Institute, University of São Paulo Medical School, São Paulo (R.S.), and Complexo Hospitalar Santa Casa de Porto Alegre, Pulmonary Vascular Research Institute, Porto Alegre (G.M.) - both in Brazil; the Department of Cardiology, Centro de Investigación en Red en Enfermedades Cardiovasculares, Hospital Universitario 12 de Octubre, Universidad Complutense, Madrid (P.E.S.); Arizona Pulmonary Specialists, Phoenix (J.F.); and the Divisions of Pulmonary Sciences and Critical Care Medicine, and Cardiology, University of Colorado, Anschutz Medical Campus, Aurora (D.B.B.).
Barnes J; From the Department of Respiratory and Intensive Care Medicine, Hôpital Bicêtre, Assistance Publique-Hôpitaux de Paris, INSERM Unité Mixte de Recherche 999, Université Paris-Saclay, Le Kremlin-Bicêtre, France (M.H., D.M.); the Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor (V.M.); the National Heart and Lung Institute, Imperial College London, and the National Pulmonary Hypertension Service, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London (J.S.R.G.); the Department of Medicine, George Washington University, Washington, DC (M.G.-M.); the Department of Respiratory Medicine, Hannover Medical School, and the German Center for Lung Research - both in Hannover, Germany (M.M.H., K.M.O.); the Division of Pulmonary, Critical Care and Sleep Medicine, Tufts Medical Center (I.R.P.), and the Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital (A.W.), Boston, and Acceleron Pharma, Cambridge (S.M., J.B., P.G.L., J.O.P.) - all in Massachusetts; the Pulmonary Division-Heart Institute, University of São Paulo Medical School, São Paulo (R.S.), and Complexo Hospitalar Santa Casa de Porto Alegre, Pulmonary Vascular Research Institute, Porto Alegre (G.M.) - both in Brazil; the Department of Cardiology, Centro de Investigación en Red en Enfermedades Cardiovasculares, Hospital Universitario 12 de Octubre, Universidad Complutense, Madrid (P.E.S.); Arizona Pulmonary Specialists, Phoenix (J.F.); and the Divisions of Pulmonary Sciences and Critical Care Medicine, and Cardiology, University of Colorado, Anschutz Medical Campus, Aurora (D.B.B.).
Linde PG; From the Department of Respiratory and Intensive Care Medicine, Hôpital Bicêtre, Assistance Publique-Hôpitaux de Paris, INSERM Unité Mixte de Recherche 999, Université Paris-Saclay, Le Kremlin-Bicêtre, France (M.H., D.M.); the Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor (V.M.); the National Heart and Lung Institute, Imperial College London, and the National Pulmonary Hypertension Service, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London (J.S.R.G.); the Department of Medicine, George Washington University, Washington, DC (M.G.-M.); the Department of Respiratory Medicine, Hannover Medical School, and the German Center for Lung Research - both in Hannover, Germany (M.M.H., K.M.O.); the Division of Pulmonary, Critical Care and Sleep Medicine, Tufts Medical Center (I.R.P.), and the Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital (A.W.), Boston, and Acceleron Pharma, Cambridge (S.M., J.B., P.G.L., J.O.P.) - all in Massachusetts; the Pulmonary Division-Heart Institute, University of São Paulo Medical School, São Paulo (R.S.), and Complexo Hospitalar Santa Casa de Porto Alegre, Pulmonary Vascular Research Institute, Porto Alegre (G.M.) - both in Brazil; the Department of Cardiology, Centro de Investigación en Red en Enfermedades Cardiovasculares, Hospital Universitario 12 de Octubre, Universidad Complutense, Madrid (P.E.S.); Arizona Pulmonary Specialists, Phoenix (J.F.); and the Divisions of Pulmonary Sciences and Critical Care Medicine, and Cardiology, University of Colorado, Anschutz Medical Campus, Aurora (D.B.B.).
de Oliveira Pena J; From the Department of Respiratory and Intensive Care Medicine, Hôpital Bicêtre, Assistance Publique-Hôpitaux de Paris, INSERM Unité Mixte de Recherche 999, Université Paris-Saclay, Le Kremlin-Bicêtre, France (M.H., D.M.); the Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor (V.M.); the National Heart and Lung Institute, Imperial College London, and the National Pulmonary Hypertension Service, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London (J.S.R.G.); the Department of Medicine, George Washington University, Washington, DC (M.G.-M.); the Department of Respiratory Medicine, Hannover Medical School, and the German Center for Lung Research - both in Hannover, Germany (M.M.H., K.M.O.); the Division of Pulmonary, Critical Care and Sleep Medicine, Tufts Medical Center (I.R.P.), and the Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital (A.W.), Boston, and Acceleron Pharma, Cambridge (S.M., J.B., P.G.L., J.O.P.) - all in Massachusetts; the Pulmonary Division-Heart Institute, University of São Paulo Medical School, São Paulo (R.S.), and Complexo Hospitalar Santa Casa de Porto Alegre, Pulmonary Vascular Research Institute, Porto Alegre (G.M.) - both in Brazil; the Department of Cardiology, Centro de Investigación en Red en Enfermedades Cardiovasculares, Hospital Universitario 12 de Octubre, Universidad Complutense, Madrid (P.E.S.); Arizona Pulmonary Specialists, Phoenix (J.F.); and the Divisions of Pulmonary Sciences and Critical Care Medicine, and Cardiology, University of Colorado, Anschutz Medical Campus, Aurora (D.B.B.).
Badesch DB; From the Department of Respiratory and Intensive Care Medicine, Hôpital Bicêtre, Assistance Publique-Hôpitaux de Paris, INSERM Unité Mixte de Recherche 999, Université Paris-Saclay, Le Kremlin-Bicêtre, France (M.H., D.M.); the Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor (V.M.); the National Heart and Lung Institute, Imperial College London, and the National Pulmonary Hypertension Service, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London (J.S.R.G.); the Department of Medicine, George Washington University, Washington, DC (M.G.-M.); the Department of Respiratory Medicine, Hannover Medical School, and the German Center for Lung Research - both in Hannover, Germany (M.M.H., K.M.O.); the Division of Pulmonary, Critical Care and Sleep Medicine, Tufts Medical Center (I.R.P.), and the Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital (A.W.), Boston, and Acceleron Pharma, Cambridge (S.M., J.B., P.G.L., J.O.P.) - all in Massachusetts; the Pulmonary Division-Heart Institute, University of São Paulo Medical School, São Paulo (R.S.), and Complexo Hospitalar Santa Casa de Porto Alegre, Pulmonary Vascular Research Institute, Porto Alegre (G.M.) - both in Brazil; the Department of Cardiology, Centro de Investigación en Red en Enfermedades Cardiovasculares, Hospital Universitario 12 de Octubre, Universidad Complutense, Madrid (P.E.S.); Arizona Pulmonary Specialists, Phoenix (J.F.); and the Divisions of Pulmonary Sciences and Critical Care Medicine, and Cardiology, University of Colorado, Anschutz Medical Campus, Aurora (D.B.B.).
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Corporate Authors :
PULSAR Trial Investigators
Źródło :
The New England journal of medicine [N Engl J Med] 2021 Apr 01; Vol. 384 (13), pp. 1204-1215.
Typ publikacji :
Clinical Trial, Phase II; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Pulmonary Arterial Hypertension/*drug therapy
Recombinant Fusion Proteins/*therapeutic use
Transforming Growth Factor beta/*antagonists & inhibitors
Vascular Resistance/*drug effects
Adult ; Dose-Response Relationship, Drug ; Double-Blind Method ; Exercise Tolerance/drug effects ; Female ; Humans ; Injections, Subcutaneous ; Least-Squares Analysis ; Male ; Middle Aged ; Natriuretic Peptide, Brain/blood ; Peptide Fragments/blood ; Pulmonary Arterial Hypertension/blood ; Pulmonary Arterial Hypertension/physiopathology ; Recombinant Fusion Proteins/adverse effects ; Recombinant Fusion Proteins/pharmacology ; Thrombocytopenia/chemically induced ; Walk Test
Czasopismo naukowe
Tytuł :
Inhibiting miR‑1 attenuates pulmonary arterial hypertension in rats.
Autorzy :
Liu Y; Department of Intensive Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.
Li Y; Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.
Li J; Department of Intensive Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.
Zuo X; Department of Intensive Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.
Cao Q; Department of Intensive Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.
Xie W; Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.
Wang H; Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.
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Źródło :
Molecular medicine reports [Mol Med Rep] 2021 Apr; Vol. 23 (4). Date of Electronic Publication: 2021 Feb 19.
Typ publikacji :
Journal Article
MeSH Terms :
Connective Tissue Growth Factor/*genetics
Familial Primary Pulmonary Hypertension/*therapy
MicroRNAs/*genetics
Pulmonary Arterial Hypertension/*therapy
Animals ; Antagomirs/pharmacology ; Disease Models, Animal ; Familial Primary Pulmonary Hypertension/genetics ; Familial Primary Pulmonary Hypertension/pathology ; Gene Expression Regulation/genetics ; Heart Ventricles/drug effects ; Heart Ventricles/pathology ; Humans ; MicroRNAs/antagonists & inhibitors ; Pulmonary Arterial Hypertension/genetics ; Pulmonary Arterial Hypertension/pathology ; Rats ; Rats, Sprague-Dawley ; Ventricular Remodeling/genetics
Czasopismo naukowe
Tytuł :
Metabolic remodeling in the right ventricle of rats with severe pulmonary arterial hypertension.
Autorzy :
Sakao S; Department of Respirology (B2), Graduate School of Medicine, Chiba University, Chiba 260‑8670, Japan.
Kawakami E; Artificial Intelligence Medicine, Graduate School of Medicine, Chiba University, Chiba 260‑8670, Japan.
Shoji H; Department of Respirology (B2), Graduate School of Medicine, Chiba University, Chiba 260‑8670, Japan.
Naito A; Department of Respirology (B2), Graduate School of Medicine, Chiba University, Chiba 260‑8670, Japan.
Miwa H; Department of Respirology (B2), Graduate School of Medicine, Chiba University, Chiba 260‑8670, Japan.
Suda R; Department of Respirology (B2), Graduate School of Medicine, Chiba University, Chiba 260‑8670, Japan.
Sanada TJ; Department of Respirology (B2), Graduate School of Medicine, Chiba University, Chiba 260‑8670, Japan.
Tanabe N; Department of Respirology (B2), Graduate School of Medicine, Chiba University, Chiba 260‑8670, Japan.
Tatsumi K; Department of Respirology (B2), Graduate School of Medicine, Chiba University, Chiba 260‑8670, Japan.
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Źródło :
Molecular medicine reports [Mol Med Rep] 2021 Apr; Vol. 23 (4). Date of Electronic Publication: 2021 Jan 26.
Typ publikacji :
Journal Article
MeSH Terms :
Fatty Acids/*metabolism
Hypertrophy, Right Ventricular/*drug therapy
Indoles/*pharmacology
Pulmonary Arterial Hypertension/*drug therapy
Pyrroles/*pharmacology
Animals ; Citric Acid Cycle/genetics ; Glucose/metabolism ; Heart Ventricles/drug effects ; Heart Ventricles/metabolism ; Heart Ventricles/pathology ; Humans ; Hypertrophy, Right Ventricular/genetics ; Hypertrophy, Right Ventricular/metabolism ; Hypoxia/genetics ; Hypoxia/metabolism ; Hypoxia/pathology ; Oxidation-Reduction/drug effects ; Pulmonary Arterial Hypertension/genetics ; Pulmonary Arterial Hypertension/pathology ; Rats ; Rats, Sprague-Dawley ; Ventricular Remodeling/drug effects ; Ventricular Remodeling/genetics
Czasopismo naukowe
Tytuł :
[Efficacy of emergent systemic-pulmonary arterial anastomosis (Potts shunt) in a child with severe idiopathic pulmonary hypertension].
Autorzy :
Zhang H; Department of Cardio-Thoracic Surgery, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, National Children's Medical Center, Shanghai 200127, China Shanghai Institution of Pediatric Congenital Heart Disease, Shanghai 200127, China.
Peng YX; Department of Cardio-Thoracic Surgery, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, National Children's Medical Center, Shanghai 200127, China.
Sun YJ; Department of Cardio-Thoracic Surgery, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, National Children's Medical Center, Shanghai 200127, China.
Xu ZM; Department of Cardio-Thoracic Surgery, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, National Children's Medical Center, Shanghai 200127, China Shanghai Institution of Pediatric Congenital Heart Disease, Shanghai 200127, China.
Bai J; Department of Anesthesiology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, National Children's Medical Center, Shanghai 200127, China.
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Źródło :
Zhonghua xin xue guan bing za zhi [Zhonghua Xin Xue Guan Bing Za Zhi] 2021 Jun 24; Vol. 49 (6), pp. 621-623.
Typ publikacji :
Journal Article
MeSH Terms :
Hypertension, Pulmonary*/surgery
Pulmonary Arterial Hypertension*
Anastomosis, Surgical ; Child ; Familial Primary Pulmonary Hypertension ; Humans ; Pulmonary Artery/surgery
Czasopismo naukowe
Tytuł :
Efficacy and safety of riociguat in the treatment of chronic thromboembolic pulmonary arterial hypertension: A meta-analysis.
Autorzy :
Ying M; Department of Pharmacy, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Song J
Gu S
Zhao R
Li M
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Źródło :
Medicine [Medicine (Baltimore)] 2021 Jun 04; Vol. 100 (22), pp. e26211.
Typ publikacji :
Journal Article; Meta-Analysis
MeSH Terms :
Enzyme Activators/*therapeutic use
Pulmonary Arterial Hypertension/*drug therapy
Pulmonary Embolism/*drug therapy
Pyrazoles/*therapeutic use
Pyrimidines/*therapeutic use
Adult ; Aged ; Case-Control Studies ; China/epidemiology ; Chronic Disease ; Data Management ; Enzyme Activators/administration & dosage ; Enzyme Activators/adverse effects ; Exercise Tolerance/drug effects ; Female ; Hemodynamics/drug effects ; Humans ; Male ; Middle Aged ; Placebos/administration & dosage ; Pulmonary Arterial Hypertension/complications ; Pulmonary Embolism/complications ; Pyrazoles/administration & dosage ; Pyrazoles/adverse effects ; Pyrimidines/administration & dosage ; Pyrimidines/adverse effects ; Randomized Controlled Trials as Topic ; Safety ; Soluble Guanylyl Cyclase/drug effects ; Treatment Outcome
Czasopismo naukowe
Tytuł :
ERK/Drp1-dependent mitochondrial fission contributes to HMGB1-induced autophagy in pulmonary arterial hypertension.
Autorzy :
Feng W; Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Wang J; Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Yan X; Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Zhang Q; Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Chai L; Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Wang Q; Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Shi W; Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Chen Y; Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Liu J; Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Qu Z; Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Li S; Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Xie X; Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Li M; Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
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Źródło :
Cell proliferation [Cell Prolif] 2021 Jun; Vol. 54 (6), pp. e13048. Date of Electronic Publication: 2021 May 04.
Typ publikacji :
Journal Article
MeSH Terms :
Autophagy*
MAP Kinase Signaling System*
Mitochondrial Dynamics*
Dynamins/*metabolism
HMGB1 Protein/*metabolism
Pulmonary Arterial Hypertension/*metabolism
Animals ; Cells, Cultured ; Male ; Mitochondria/metabolism ; Mitochondria/pathology ; Phosphorylation ; Pulmonary Arterial Hypertension/pathology ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
REPLACE and the role of riociguat in pulmonary arterial hypertension therapy.
Autorzy :
Frantz RP; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55902, USA. Electronic address: .
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Źródło :
The Lancet. Respiratory medicine [Lancet Respir Med] 2021 Jun; Vol. 9 (6), pp. 546-547. Date of Electronic Publication: 2021 Mar 24.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Pulmonary Arterial Hypertension*
Cyclic Nucleotide Phosphodiesterases, Type 5 ; Humans ; Phosphodiesterase 5 Inhibitors ; Pyrazoles ; Pyrimidines
Czasopismo naukowe
Tytuł :
The m A methyltransferase METTL3 promotes hypoxic pulmonary arterial hypertension.
Autorzy :
Qin Y; Department of Cardiology, Zhongda Hospital, School of Medicine, Southeast University, 87 Dingjiaqiao, Nanjing 210009, PR China.
Qiao Y; Department of Cardiology, Zhongda Hospital, School of Medicine, Southeast University, 87 Dingjiaqiao, Nanjing 210009, PR China.
Li L; Department of Cardiology, Zhongda Hospital, School of Medicine, Southeast University, 87 Dingjiaqiao, Nanjing 210009, PR China.
Luo E; Department of Cardiology, Zhongda Hospital, School of Medicine, Southeast University, 87 Dingjiaqiao, Nanjing 210009, PR China.
Wang D; Department of Cardiology, Zhongda Hospital, School of Medicine, Southeast University, 87 Dingjiaqiao, Nanjing 210009, PR China.
Yao Y; Department of Cardiology, Zhongda Hospital, School of Medicine, Southeast University, 87 Dingjiaqiao, Nanjing 210009, PR China.
Tang C; Department of Cardiology, Zhongda Hospital, School of Medicine, Southeast University, 87 Dingjiaqiao, Nanjing 210009, PR China. Electronic address: .
Yan G; Department of Cardiology, Zhongda Hospital, School of Medicine, Southeast University, 87 Dingjiaqiao, Nanjing 210009, PR China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Jun 01; Vol. 274, pp. 119366. Date of Electronic Publication: 2021 Mar 16.
Typ publikacji :
Journal Article
MeSH Terms :
Adenosine/*analogs & derivatives
Hypoxia/*physiopathology
Methyltransferases/*metabolism
Myocytes, Smooth Muscle/*pathology
Pulmonary Arterial Hypertension/*pathology
Pulmonary Artery/*pathology
RNA, Messenger/*metabolism
Adenosine/chemistry ; Animals ; Apoptosis ; Cell Proliferation ; Male ; Methylation ; Methyltransferases/genetics ; Myocytes, Smooth Muscle/metabolism ; PTEN Phosphohydrolase/genetics ; PTEN Phosphohydrolase/metabolism ; Pulmonary Arterial Hypertension/metabolism ; Pulmonary Artery/metabolism ; RNA, Messenger/chemistry ; RNA, Messenger/genetics ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism ; Rats ; Rats, Sprague-Dawley ; Signal Transduction
Czasopismo naukowe
Tytuł :
Reply: COVID-19 Experience and Pulmonary Arterial Hypertension: Do Earlier Theses and New Data Still Match?
Autorzy :
Lee JD; University of Washington Seattle, Washington.
Burger CD; Mayo Clinic Florida Jacksonville, Florida, and.
Rayner SG; University of Washington Seattle, Washington.
Ryan JJ; University of Utah Salt Lake City, Utah.
Leary PJ; University of Washington Seattle, Washington.
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Źródło :
Annals of the American Thoracic Society [Ann Am Thorac Soc] 2021 Jun; Vol. 18 (6), pp. 1081-1082.
Typ publikacji :
Letter; Comment
MeSH Terms :
COVID-19*
Hypertension, Pulmonary*
Pulmonary Arterial Hypertension*
Familial Primary Pulmonary Hypertension ; Humans ; SARS-CoV-2
Opinia redakcyjna
Tytuł :
COVID-19 Experience and Pulmonary Arterial Hypertension: Do Earlier Theses and New Data Still Match?
Autorzy :
Segura de la Cal T; Hospital Universitario 12 de Octubre Madrid, Spain.
Nuche J; Hospital Universitario 12 de Octubre Madrid, Spain.; En Red de enfermedades CardioVasculares (CIBERCV) Madrid, Spain.; Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain, and.; Universidad Complutense de Madrid Madrid, Spain.
Jiménez López-Guarch C; Hospital Universitario 12 de Octubre Madrid, Spain.; En Red de enfermedades CardioVasculares (CIBERCV) Madrid, Spain.; Universidad Complutense de Madrid Madrid, Spain.
Pérez-Olivares C; Hospital Universitario 12 de Octubre Madrid, Spain.
Cristo MJ; Hospital Universitario 12 de Octubre Madrid, Spain.
Oliver E; En Red de enfermedades CardioVasculares (CIBERCV) Madrid, Spain.; Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain, and.
Escribano Subías P; Hospital Universitario 12 de Octubre Madrid, Spain.; En Red de enfermedades CardioVasculares (CIBERCV) Madrid, Spain.; Universidad Complutense de Madrid Madrid, Spain.
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Źródło :
Annals of the American Thoracic Society [Ann Am Thorac Soc] 2021 Jun; Vol. 18 (6), pp. 1080-1081.
Typ publikacji :
Letter; Comment
MeSH Terms :
COVID-19*
Hypertension, Pulmonary*
Pulmonary Arterial Hypertension*
Humans ; Incidence ; SARS-CoV-2
Opinia redakcyjna
Tytuł :
[2020 Chinese expert-based consensus statement regarding the diagnosis and treatment of connective tissue disease associated pulmonary arterial hypertension].
Corporate Authors :
Group of Pulmonary Vascular and Interstitial Diseases Associated with Rheumatic Diseases, Chinese Association of Rheumatology and Immunology Physicians
Chinese Rheumatism Data Center
National Clinical Research Center for Dermatologic and Immunologic Diseases
Źródło :
Zhonghua nei ke za zhi [Zhonghua Nei Ke Za Zhi] 2021 May 01; Vol. 60 (5), pp. 406-420.
Typ publikacji :
Journal Article
MeSH Terms :
Connective Tissue Diseases*/complications
Connective Tissue Diseases*/diagnosis
Connective Tissue Diseases*/therapy
Pulmonary Arterial Hypertension*
China ; Consensus ; Familial Primary Pulmonary Hypertension ; Humans
Czasopismo naukowe
Tytuł :
[Organ Bath Experiments on Human Pulmonary Vessels: Assessment of Drug Efficacy for Treatment of Pulmonary Arterial Hypertension].
Autorzy :
Stadlbauer C; Klinik und Poliklinik für Herz-, Thorax- und herznahe Gefäßchirurgie, Universitätsklinikum Regensburg, Regensburg.
Golovchenko S; Klinik und Poliklinik für Herz-, Thorax- und herznahe Gefäßchirurgie, Universitätsklinikum Regensburg, Regensburg.
Englert L; Klinik und Poliklinik für Herz-, Thorax- und herznahe Gefäßchirurgie, Universitätsklinikum Regensburg, Regensburg.
Spaeth M; Klinik und Poliklinik für Herz-, Thorax- und herznahe Gefäßchirurgie, Universitätsklinikum Regensburg, Regensburg.
Hoenicka M; Klinik für Herz- und Thoraxchirurgie, Universitätsklinikum Ulm, Ulm.
Hofmann HS; Klinik und Poliklinik für Herz-, Thorax- und herznahe Gefäßchirurgie, Universitätsklinikum Regensburg, Regensburg.; Klinik für Thoraxchirurgie, Krankenhaus Barmherzige Brüder Regensburg, Regensburg.
Ried M; Klinik und Poliklinik für Herz-, Thorax- und herznahe Gefäßchirurgie, Universitätsklinikum Regensburg, Regensburg.
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Transliterated Title :
Organbadversuche an humanen Pulmonalgefäßen: Beurteilung der Medikamentenwirkung zur Behandlung der pulmonalarteriellen Hypertonie.
Źródło :
Pneumologie (Stuttgart, Germany) [Pneumologie] 2021 May; Vol. 75 (5), pp. 369-376. Date of Electronic Publication: 2021 Jan 20.
Typ publikacji :
Journal Article
MeSH Terms :
Hypertension, Pulmonary*/drug therapy
Pharmaceutical Preparations*
Pulmonary Arterial Hypertension*
Antihypertensive Agents ; Drug Therapy, Combination ; Humans ; Phosphodiesterase 5 Inhibitors/therapeutic use
Czasopismo naukowe
Tytuł :
Zooming into Cellular and Molecular Heterogeneity of Pulmonary Hypertension. What More Single-Cell Omics Can Offer.
Autorzy :
Chelladurai P; Max Planck Institute for Heart and Lung Research German Center for Lung Research (DZL) Cardio-Pulmonary Institute (CPI) Bad Nauheim, Germany.
Savai R; Max Planck Institute for Heart and Lung Research German Center for Lung Research (DZL) Cardio-Pulmonary Institute (CPI) Bad Nauheim, Germany.; Institute for Lung Health (ILH) Justus Liebig University Giessen, Germany and.
Pullamsetti SS; Max Planck Institute for Heart and Lung Research German Center for Lung Research (DZL) Cardio-Pulmonary Institute (CPI) Bad Nauheim, Germany.; Department of Internal Medicine German Center for Lung Research (DZL) Cardio-Pulmonary Institute (CPI) Justus Liebig University Giessen, Germany.
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Źródło :
American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2021 Apr 15; Vol. 203 (8), pp. 941-943.
Typ publikacji :
Editorial; Research Support, Non-U.S. Gov't; Comment
MeSH Terms :
Hypertension, Pulmonary*/genetics
Pulmonary Arterial Hypertension*
Animals ; Drug Repositioning ; Genomics ; Humans ; Metabolomics ; Rats
Raport
Tytuł :
Regional Variation in Methamphetamine-associated Pulmonary Arterial Hypertension: Who'd Better Call Saul?
Autorzy :
Prohaska CC; Division of Pulmonary, Critical Care, Sleep, and Occupational Medicine, Department of Medicine, Indiana University, Indianapolis, Indiana.
Machado RF; Division of Pulmonary, Critical Care, Sleep, and Occupational Medicine, Department of Medicine, Indiana University, Indianapolis, Indiana.
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Źródło :
Annals of the American Thoracic Society [Ann Am Thorac Soc] 2021 Apr; Vol. 18 (4), pp. 584-585.
Typ publikacji :
Editorial; Research Support, N.I.H., Extramural; Comment
MeSH Terms :
Hypertension, Pulmonary*/chemically induced
Methamphetamine*/adverse effects
Pulmonary Arterial Hypertension*
Familial Primary Pulmonary Hypertension ; Humans ; Registries
Raport
Tytuł :
Commentary: Potts shunt for pulmonary hypertension: Are we making progress?
Autorzy :
Miller JR; Section of Pediatric Cardiothoracic Surgery, Division of Cardiothoracic Surgery, Department of Surgery, Washington University in St Louis School of Medicine/St Louis Children's Hospital, St Louis, Mo.
Eghtesady P; Section of Pediatric Cardiothoracic Surgery, Division of Cardiothoracic Surgery, Department of Surgery, Washington University in St Louis School of Medicine/St Louis Children's Hospital, St Louis, Mo. Electronic address: .
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Źródło :
The Journal of thoracic and cardiovascular surgery [J Thorac Cardiovasc Surg] 2021 Apr; Vol. 161 (4), pp. 1449-1450. Date of Electronic Publication: 2021 Jan 28.
Typ publikacji :
Editorial; Comment
MeSH Terms :
Hypertension, Pulmonary*
Pulmonary Arterial Hypertension*
Adolescent ; Adult ; Aorta, Thoracic ; Humans ; Pulmonary Artery/surgery
Opinia redakcyjna
Tytuł :
Commentary: Right ventricular unloading with valved conduit for end-stage pulmonary arterial hypertension: When Eisenmenger is the last hurrah.
Autorzy :
Said SM; Division of Pediatric Cardiovascular Surgery, Masonic Children's Hospital, University of Minnesota, Minneapolis, Minn. Electronic address: .
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Źródło :
The Journal of thoracic and cardiovascular surgery [J Thorac Cardiovasc Surg] 2021 Apr; Vol. 161 (4), pp. 1447-1448. Date of Electronic Publication: 2021 Jan 22.
Typ publikacji :
Editorial; Comment
MeSH Terms :
Bioprosthesis*
Pulmonary Arterial Hypertension*
Pulmonary Valve*
Adolescent ; Adult ; Humans
Opinia redakcyjna

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