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Tytuł:
Specialized DNA Structures Act as Genomic Beacons for Integration by Evolutionarily Diverse Retroviruses.
Autorzy:
Kohio HP; Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, Dental Sciences Building Room 3007, London, ON N6A 3K7, Canada.
Ajoge HO; Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, Dental Sciences Building Room 3007, London, ON N6A 3K7, Canada.
Coleman MD; Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, Dental Sciences Building Room 3007, London, ON N6A 3K7, Canada.
Ndashimye E; Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, Dental Sciences Building Room 3007, London, ON N6A 3K7, Canada.
Gibson RM; Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, Dental Sciences Building Room 3007, London, ON N6A 3K7, Canada.
Arts EJ; Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, Dental Sciences Building Room 3007, London, ON N6A 3K7, Canada.
Barr SD; Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, Dental Sciences Building Room 3007, London, ON N6A 3K7, Canada.
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Źródło:
Viruses [Viruses] 2023 Feb 07; Vol. 15 (2). Date of Electronic Publication: 2023 Feb 07.
Typ publikacji:
Meta-Analysis; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
HIV Seropositivity*
HIV-1*/genetics
Humans ; Retroviridae/genetics ; Genomics ; DNA
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
First-line HIV treatment failures in non-B subtypes and recombinants: a cross-sectional analysis of multiple populations in Uganda.
Autorzy:
Poon AFY; Department of Pathology and Laboratory Medicine, Health Sciences Addition, H422, Western University, London, ON, N6G 2R5, Canada. .; Department of Microbiology and Immunology, Western University, London, Canada. .; Department of Applied Mathematics, Western University, London, Canada. .
Ndashimye E; Department of Microbiology and Immunology, Western University, London, Canada.; Joint Clinical Research Centre, Kampala, Uganda.
Avino M; Department of Pathology and Laboratory Medicine, Health Sciences Addition, H422, Western University, London, ON, N6G 2R5, Canada.
Gibson R; Department of Microbiology and Immunology, Western University, London, Canada.
Kityo C; Joint Clinical Research Centre, Kampala, Uganda.
Kyeyune F; Center for AIDS Research Uganda Laboratories, Joint Clinical Research Centre, Kampala, Uganda.; Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, OH, USA.
Nankya I; Center for AIDS Research Uganda Laboratories, Joint Clinical Research Centre, Kampala, Uganda.; Department of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Quiñones-Mateu ME; Center for AIDS Research Uganda Laboratories, Joint Clinical Research Centre, Kampala, Uganda.; Department of Medicine, Case Western Reserve University, Cleveland, OH, USA.; Department of Pathology, Case Western Reserve University, Cleveland, OH, USA.
Arts EJ; Department of Microbiology and Immunology, Western University, London, Canada.; Center for AIDS Research Uganda Laboratories, Joint Clinical Research Centre, Kampala, Uganda.
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Corporate Authors:
The Ugandan Drug Resistance Study Team
Źródło:
AIDS research and therapy [AIDS Res Ther] 2019 Jan 22; Vol. 16 (1), pp. 3. Date of Electronic Publication: 2019 Jan 22.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Recombination, Genetic*
Anti-Retroviral Agents/*therapeutic use
HIV Infections/*drug therapy
HIV-1/*drug effects
HIV-1/*genetics
Adolescent ; Adult ; Bayes Theorem ; Cohort Studies ; Cross-Sectional Studies ; Drug Resistance, Viral ; Female ; Genotype ; HIV Infections/virology ; HIV Seropositivity ; HIV-1/classification ; Humans ; Male ; Sequence Analysis, DNA ; Treatment Failure ; Uganda ; Young Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Higher sequence diversity in the vaginal tract than in blood at early HIV-1 infection.
Autorzy:
Klein K; Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada.; Department of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America.
Nickel G; Department of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America.
Nankya I; Joint Clinical Research Centre, Kampala, Uganda.
Kyeyune F; Joint Clinical Research Centre, Kampala, Uganda.
Demers K; Department of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America.; Joint Clinical Research Centre, Kampala, Uganda.
Ndashimye E; Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada.; Joint Clinical Research Centre, Kampala, Uganda.
Kwok C; FHI 360, Durham, North Carolina, United States of America.
Chen PL; FHI 360, Durham, North Carolina, United States of America.
Rwambuya S; Department of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America.; Joint Clinical Research Centre, Kampala, Uganda.
Poon A; Department of Pathology and Laboratory Medicine, University of Western Ontario, London, Ontario, Canada.
Munjoma M; Department of Obstetrics and Gynaecology, University of Zimbabwe, Harare, Zimbabwe.
Chipato T; Department of Obstetrics and Gynaecology, University of Zimbabwe, Harare, Zimbabwe.
Byamugisha J; Faculty of Medicine, Makerere University, Kampala, Uganda.
Mugyenyi P; Joint Clinical Research Centre, Kampala, Uganda.
Salata RA; Department of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America.
Morrison CS; FHI 360, Durham, North Carolina, United States of America.
Arts EJ; Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada.; Department of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America.; Joint Clinical Research Centre, Kampala, Uganda.
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Źródło:
PLoS pathogens [PLoS Pathog] 2018 Jan 18; Vol. 14 (1), pp. e1006754. Date of Electronic Publication: 2018 Jan 18 (Print Publication: 2018).
Typ publikacji:
Comparative Study; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural
MeSH Terms:
Genetic Variation*
Cervix Uteri/*virology
HIV Infections/*virology
HIV Seropositivity/*virology
HIV-1/*genetics
Vagina/*virology
Viremia/*virology
Base Sequence ; Cohort Studies ; Female ; HIV Seropositivity/blood ; HIV-1/isolation & purification ; High-Throughput Nucleotide Sequencing ; Humans ; Longitudinal Studies ; RNA, Viral/blood ; RNA, Viral/chemistry ; RNA, Viral/isolation & purification ; Reproductive Tract Infections/blood ; Reproductive Tract Infections/virology ; Uganda ; Viral Load ; Viremia/blood ; Zimbabwe ; env Gene Products, Human Immunodeficiency Virus/chemistry ; env Gene Products, Human Immunodeficiency Virus/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Sensitive detection of HIV-1 resistance to Zidovudine and impact on treatment outcomes in low- to middle-income countries.
Autorzy:
Gibson RM; Department of Microbiology and Immunology, University of Western Ontario, 1151 Richmond St., Dental Sciences Bldg., Rm 3014, London, Ontario, N6A 5C1, Canada.
Nickel G; Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Crawford M; Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Kyeyune F; Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, OH, USA.; Department of Pathology, Case Western Reserve University, Cleveland, OH, USA.
Venner C; Department of Microbiology and Immunology, University of Western Ontario, 1151 Richmond St., Dental Sciences Bldg., Rm 3014, London, Ontario, N6A 5C1, Canada.
Nankya I; Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, OH, USA.; Center for AIDS Research Uganda Laboratories, Joint Clinical Research Centre, Kampala, Uganda.; Department of Pathology and Laboratory Medicine, University of Western Ontario, Kampala, Uganda.
Nabulime E; Center for AIDS Research Uganda Laboratories, Joint Clinical Research Centre, Kampala, Uganda.
Ndashimye E; Center for AIDS Research Uganda Laboratories, Joint Clinical Research Centre, Kampala, Uganda.
Poon AFY; Department of Pathology and Laboratory Medicine, University of Western Ontario, Kampala, Uganda.
Salata RA; Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Kityo C; Center for AIDS Research Uganda Laboratories, Joint Clinical Research Centre, Kampala, Uganda.
Mugyenyi P; Center for AIDS Research Uganda Laboratories, Joint Clinical Research Centre, Kampala, Uganda.
Quiñones-Mateu ME; Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, OH, USA.; Department of Pathology, Case Western Reserve University, Cleveland, OH, USA.; Center for AIDS Research Uganda Laboratories, Joint Clinical Research Centre, Kampala, Uganda.
Arts EJ; Department of Microbiology and Immunology, University of Western Ontario, 1151 Richmond St., Dental Sciences Bldg., Rm 3014, London, Ontario, N6A 5C1, Canada. .; TREAT, Joint Clinical Research Centre, Kampala, Uganda. .
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Źródło:
Infectious diseases of poverty [Infect Dis Poverty] 2017 Dec 04; Vol. 6 (1), pp. 163. Date of Electronic Publication: 2017 Dec 04.
Typ publikacji:
Journal Article
MeSH Terms:
Drug Resistance, Viral*
Treatment Outcome*
Anti-HIV Agents/*therapeutic use
HIV Infections/*drug therapy
HIV-1/*drug effects
Zidovudine/*therapeutic use
Adolescent ; Adult ; Anti-HIV Agents/pharmacology ; CD4 Lymphocyte Count ; Child ; Child, Preschool ; Cohort Studies ; Female ; Humans ; Male ; Middle Aged ; Treatment Failure ; Uganda ; Viral Load ; Young Adult ; Zidovudine/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
First Phase I human clinical trial of a killed whole-HIV-1 vaccine: demonstration of its safety and enhancement of anti-HIV antibody responses.
Autorzy:
Choi E; Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, The University of Western Ontario, 1400 Western Road, London, ON, N6G 2V4, Canada.; Sumagen Canada Inc., London, ON, Canada.
Michalski CJ; Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, The University of Western Ontario, 1400 Western Road, London, ON, N6G 2V4, Canada.
Choo SH; Sumagen Canada Inc., London, ON, Canada.
Kim GN; Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, The University of Western Ontario, 1400 Western Road, London, ON, N6G 2V4, Canada.
Banasikowska E; Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, The University of Western Ontario, 1400 Western Road, London, ON, N6G 2V4, Canada.
Lee S; Sumagen Canada Inc., London, ON, Canada.
Wu K; Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, The University of Western Ontario, 1400 Western Road, London, ON, N6G 2V4, Canada.
An HY; Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, The University of Western Ontario, 1400 Western Road, London, ON, N6G 2V4, Canada.
Mills A; Anthony M. Mills Internal Medicine, West Hollywood, CA, USA.
Schneider S; Long Beach Education and Research Consultants, Long Beach, CA, USA.
Bredeek UF; Metropolis Medical PC, San Francisco, CA, USA.
Coulston DR; Rockwood Clinics, P.C., Spokane, WA, USA.
Ding S; Centre de Recherche du CHUM, Department of Microbiology, Université de Montréal, Montreal, QC, Canada.
Finzi A; Centre de Recherche du CHUM, Department of Microbiology, Université de Montréal, Montreal, QC, Canada.
Tian M; Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, The University of Western Ontario, 1400 Western Road, London, ON, N6G 2V4, Canada.
Klein K; Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, The University of Western Ontario, 1400 Western Road, London, ON, N6G 2V4, Canada.
Arts EJ; Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, The University of Western Ontario, 1400 Western Road, London, ON, N6G 2V4, Canada.
Mann JF; Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, The University of Western Ontario, 1400 Western Road, London, ON, N6G 2V4, Canada.
Gao Y; Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, The University of Western Ontario, 1400 Western Road, London, ON, N6G 2V4, Canada.
Kang CY; Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, The University of Western Ontario, 1400 Western Road, London, ON, N6G 2V4, Canada. .
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Źródło:
Retrovirology [Retrovirology] 2016 Nov 28; Vol. 13 (1), pp. 82. Date of Electronic Publication: 2016 Nov 28.
Typ publikacji:
Clinical Trial, Phase I; Journal Article; Randomized Controlled Trial
MeSH Terms:
AIDS Vaccines*/administration & dosage
AIDS Vaccines*/adverse effects
AIDS Vaccines*/immunology
Immunogenicity, Vaccine*
Antibodies, Neutralizing/*blood
HIV Antibodies/*blood
HIV Infections/*prevention & control
HIV-1/*immunology
Adult ; Animals ; Antibodies, Neutralizing/immunology ; Bees/genetics ; Female ; Gene Products, nef/genetics ; HIV Antibodies/immunology ; HIV Infections/immunology ; HIV-1/genetics ; Human Immunodeficiency Virus Proteins/genetics ; Humans ; Male ; Middle Aged ; Protein Sorting Signals ; Vaccines, Inactivated/administration & dosage ; Vaccines, Inactivated/adverse effects ; Vaccines, Inactivated/immunology ; Viral Regulatory and Accessory Proteins/genetics ; Young Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Infection of rhesus macaques with a pool of simian immunodeficiency virus with the envelope genes from acute HIV-1 infections.
Autorzy:
Krebs KC; Division of Infectious Diseases, School of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106 USA.
Tian M; Division of Infectious Diseases, School of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106 USA.; Department of Microbiology and Immunology, Schulich School of Medicine & Dentistry, University of Western Ontario, 1151 Richmond St., London, ON N6A 5C1 Canada.
Asmal M; Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115 USA.
Ling B; Tulane National Primate Research Center, Tulane University School of Medicine, 18703 Three Rivers Road, Covington, LA 70433 USA.
Nelson K; Division of Infectious Diseases, School of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106 USA.
Henry K; Division of Infectious Diseases, School of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106 USA.
Gibson R; Division of Infectious Diseases, School of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106 USA.; Department of Microbiology and Immunology, Schulich School of Medicine & Dentistry, University of Western Ontario, 1151 Richmond St., London, ON N6A 5C1 Canada.
Li Y; Division of Infectious Diseases, School of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106 USA.
Han W; Division of Infectious Diseases, School of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106 USA.
Shattock RJ; Division of Medicine, Department of Infectious Diseases, Imperial College London, Norfolk Place, London, W2 1PG UK.
Veazey RS; Tulane National Primate Research Center, Tulane University School of Medicine, 18703 Three Rivers Road, Covington, LA 70433 USA.
Letvin N; Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115 USA.
Arts EJ; Division of Infectious Diseases, School of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106 USA.; Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106 USA.; Department of Microbiology and Immunology, Schulich School of Medicine & Dentistry, University of Western Ontario, 1151 Richmond St., London, ON N6A 5C1 Canada.
Gao Y; Division of Infectious Diseases, School of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106 USA.; Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106 USA.; Department of Microbiology and Immunology, Schulich School of Medicine & Dentistry, University of Western Ontario, 1151 Richmond St., London, ON N6A 5C1 Canada.
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Źródło:
AIDS research and therapy [AIDS Res Ther] 2016 Nov 25; Vol. 13 (1), pp. 41. Date of Electronic Publication: 2016 Nov 25.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
HIV Infections/*genetics
HIV-1/*genetics
Macaca mulatta/*virology
Simian Acquired Immunodeficiency Syndrome/*genetics
Simian Acquired Immunodeficiency Syndrome/*virology
Simian Immunodeficiency Virus/*genetics
Animals ; Cell Line ; Genes, env ; Glycosylation ; HEK293 Cells ; HIV Infections/virology ; Humans ; Mutation ; Simian Immunodeficiency Virus/pathogenicity ; Virus Replication/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Functional bottlenecks for generation of HIV-1 intersubtype Env recombinants.
Autorzy:
Bagaya BS; Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH, 44106, USA. .
Vega JF; Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH, 44106, USA. .
Tian M; Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, London, ON, N6A 5C1, Canada. .
Nickel GC; Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH, 44106, USA. .
Li Y; Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH, 44106, USA. .
Krebs KC; Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH, 44106, USA. .
Arts EJ; Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, London, ON, N6A 5C1, Canada. .
Gao Y; Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH, 44106, USA. .; Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH, 44106, USA. .
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Źródło:
Retrovirology [Retrovirology] 2015 May 23; Vol. 12, pp. 44. Date of Electronic Publication: 2015 May 23.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Recombination, Genetic*
HIV Envelope Protein gp120/*genetics
HIV Envelope Protein gp41/*genetics
HIV-1/*genetics
Genotype ; HIV Envelope Protein gp120/chemistry ; HIV Envelope Protein gp41/chemistry ; Humans ; Models, Molecular ; Protein Conformation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
SiRNA-induced mutation in HIV-1 polypurine tract region and its influence on viral fitness.
Autorzy:
Rausch JW; HIV Drug Resistance Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America.
Tian M; Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America.
Li Y; Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America.
Angelova L; Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America.
Bagaya BS; Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio, United States of America.
Krebs KC; Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America.
Qian F; Suzhou Fifth People's Hospital, Suzhou, Jiangsu, China.
Zhu C; Suzhou Fifth People's Hospital, Suzhou, Jiangsu, China.
Arts EJ; Department of Microbiology and Immunology, Western University, London, Ontario, Canada.
Le Grice SF; HIV Drug Resistance Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America.
Gao Y; Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America; Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio, United States of America.
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Źródło:
PloS one [PLoS One] 2015 Apr 10; Vol. 10 (4), pp. e0122953. Date of Electronic Publication: 2015 Apr 10 (Print Publication: 2015).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
HIV-1/*physiology
3' Flanking Region ; Base Sequence ; Cell Line ; DNA Primers/genetics ; DNA Primers/metabolism ; HIV-1/enzymology ; HIV-1/genetics ; Humans ; Mutation ; RNA Interference ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; RNA, Viral/antagonists & inhibitors ; RNA, Viral/genetics ; RNA, Viral/metabolism ; Ribonuclease H/metabolism ; Sequence Alignment ; Virus Replication
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Similar replicative fitness is shared by the subtype B and unique BF recombinant HIV-1 isolates that dominate the epidemic in Argentina.
Autorzy:
Rubio AE; Centro Nacional de Referencia para el SIDA, Departamento de Microbiología, Facultad de Medicina Universidad de Buenos Aires, Buenos Aires, Argentina.
Abraha A; Division of Infectious Diseases and HIV Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America.
Carpenter CA; Division of Infectious Diseases and HIV Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America.
Troyer RM; Division of Infectious Diseases and HIV Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America.
Reyes-Rodríguez ÁL; Division of Infectious Diseases and HIV Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America.
Salomon H; Centro Nacional de Referencia para el SIDA, Departamento de Microbiología, Facultad de Medicina Universidad de Buenos Aires, Buenos Aires, Argentina.
Arts EJ; Division of Infectious Diseases and HIV Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America.
Tebit DM; Division of Infectious Diseases and HIV Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America.
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Źródło:
PloS one [PLoS One] 2014 Apr 11; Vol. 9 (4), pp. e92084. Date of Electronic Publication: 2014 Apr 11 (Print Publication: 2014).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
HIV-1/*genetics
HIV-1/*pathogenicity
Recombination, Genetic/*genetics
Argentina/epidemiology ; Genome, Viral/genetics ; HIV Infections/epidemiology ; HIV-1/classification ; Humans ; Phylogeny ; Virus Replication/genetics ; Virus Replication/physiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Impact of mutations in highly conserved amino acids of the HIV-1 Gag-p24 and Env-gp120 proteins on viral replication in different genetic backgrounds.
Autorzy:
Liu Y; Department of Microbiology, University of Washington School of Medicine, Seattle, Washington, United States of America.
Rao U; Department of Microbiology, University of Washington School of Medicine, Seattle, Washington, United States of America.
McClure J; Department of Microbiology, University of Washington School of Medicine, Seattle, Washington, United States of America.
Konopa P; Department of Microbiology, University of Washington School of Medicine, Seattle, Washington, United States of America.
Manocheewa S; Department of Microbiology, University of Washington School of Medicine, Seattle, Washington, United States of America.
Kim M; Department of Microbiology, University of Washington School of Medicine, Seattle, Washington, United States of America.
Chen L; Department of Microbiology, University of Washington School of Medicine, Seattle, Washington, United States of America.
Troyer RM; Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America.
Tebit DM; Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America.
Holte S; Program in Biostatistics and Biomathematics, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.
Arts EJ; Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America.
Mullins JI; Department of Microbiology, University of Washington School of Medicine, Seattle, Washington, United States of America; Department of Medicine, University of Washington School of Medicine, Seattle, Washington, United States of America; Department of Laboratory Medicine, University of Washington School of Medicine, Seattle, Washington, United States of America.
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Źródło:
PloS one [PLoS One] 2014 Apr 08; Vol. 9 (4), pp. e94240. Date of Electronic Publication: 2014 Apr 08 (Print Publication: 2014).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Conserved Sequence*
Mutation*
Virus Replication*
HIV Core Protein p24/*genetics
HIV Envelope Protein gp120/*genetics
HIV-1/*genetics
Amino Acid Sequence ; Genetic Fitness ; HIV Core Protein p24/chemistry ; HIV Envelope Protein gp120/chemistry ; Humans ; Molecular Sequence Data ; Sequence Alignment
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Commentary on the role of treatment-related HIV compensatory mutations on increasing virulence: new discoveries twenty years since the clinical testing of protease inhibitors to block HIV-1 replication.
Autorzy:
Arts EJ; Division of Infectious Diseases and HIV Medicine, Department of Medicine, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
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Źródło:
BMC medicine [BMC Med] 2012 Oct 03; Vol. 10, pp. 114. Date of Electronic Publication: 2012 Oct 03.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Drug Resistance, Viral*
Mutation, Missense*
HIV Infections/*virology
HIV Protease Inhibitors/*pharmacology
HIV-1/*drug effects
HIV-1/*pathogenicity
CD4 Lymphocyte Count ; Disease Progression ; HIV Infections/epidemiology ; Humans ; Viral Load ; Virulence
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Use of four next-generation sequencing platforms to determine HIV-1 coreceptor tropism.
Autorzy:
Archer J; Computational and Evolutionary Biology, Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom.
Weber J
Henry K
Winner D
Gibson R
Lee L
Paxinos E
Arts EJ
Robertson DL
Mimms L
Quiñones-Mateu ME
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Źródło:
PloS one [PLoS One] 2012; Vol. 7 (11), pp. e49602. Date of Electronic Publication: 2012 Nov 14.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
High-Throughput Nucleotide Sequencing*
Viral Tropism*
HIV-1/*physiology
Receptors, CCR5/*metabolism
Receptors, CXCR4/*metabolism
Base Sequence ; Cluster Analysis ; HIV Envelope Protein gp120/genetics ; HIV Infections/virology ; HIV-1/genetics ; Humans ; Molecular Sequence Data ; Receptors, CCR5/genetics ; Receptors, CXCR4/genetics ; Sequence Alignment
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Enrichment of intersubtype HIV-1 recombinants in a dual infection system using HIV-1 strain-specific siRNAs.
Autorzy:
Gao Y; Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, Ohio 44106, USA. />Abreha M
Nelson KN
Baird H
Dudley DM
Abraha A
Arts EJ
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Źródło:
Retrovirology [Retrovirology] 2011 Jan 13; Vol. 8 (1), pp. 5. Date of Electronic Publication: 2011 Jan 13.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Recombination, Genetic*
HIV Infections/*virology
HIV-1/*genetics
RNA, Small Interfering/*genetics
Base Sequence ; Drug Resistance, Viral ; HIV-1/isolation & purification ; HIV-1/physiology ; Humans ; Molecular Sequence Data ; Sequence Alignment ; Virus Replication ; env Gene Products, Human Immunodeficiency Virus/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Variable fitness impact of HIV-1 escape mutations to cytotoxic T lymphocyte (CTL) response.
Autorzy:
Troyer RM; Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, OH, USA.
McNevin J
Liu Y
Zhang SC
Krizan RW
Abraha A
Tebit DM
Zhao H
Avila S
Lobritz MA
McElrath MJ
Le Gall S
Mullins JI
Arts EJ
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Źródło:
PLoS pathogens [PLoS Pathog] 2009 Apr; Vol. 5 (4), pp. e1000365. Date of Electronic Publication: 2009 Apr 03.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Mutation*
Virus Replication*
HIV-1/*immunology
T-Lymphocytes, Cytotoxic/*immunology
Amino Acid Sequence ; Epitopes, T-Lymphocyte/immunology ; Evolution, Molecular ; HIV Envelope Protein gp120/genetics ; HIV Envelope Protein gp120/metabolism ; HIV-1/genetics ; HIV-1/physiology ; Human Immunodeficiency Virus Proteins/genetics ; Human Immunodeficiency Virus Proteins/metabolism ; Humans ; Models, Molecular ; Molecular Sequence Data ; Peptide Fragments/genetics ; Peptide Fragments/metabolism ; gag Gene Products, Human Immunodeficiency Virus/genetics ; gag Gene Products, Human Immunodeficiency Virus/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Elite suppressor-derived HIV-1 envelope glycoproteins exhibit reduced entry efficiency and kinetics.
Autorzy:
Lassen KG; Department of Molecular Biology and Microbiology, Department of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Lobritz MA
Bailey JR
Johnston S
Nguyen S
Lee B
Chou T
Siliciano RF
Markowitz M
Arts EJ
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Źródło:
PLoS pathogens [PLoS Pathog] 2009 Apr; Vol. 5 (4), pp. e1000377. Date of Electronic Publication: 2009 Apr 10.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Virus Internalization*
Gene Products, env/*immunology
HIV Infections/*immunology
HIV Infections/*virology
HIV-1/*pathogenicity
Blotting, Western ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/virology ; Flow Cytometry ; Humans ; Receptors, CCR5/immunology ; Reverse Transcriptase Polymerase Chain Reaction ; Viral Load
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Identifying the important HIV-1 recombination breakpoints.
Autorzy:
Archer J; Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom.
Pinney JW
Fan J
Simon-Loriere E
Arts EJ
Negroni M
Robertson DL
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Źródło:
PLoS computational biology [PLoS Comput Biol] 2008 Sep 12; Vol. 4 (9), pp. e1000178. Date of Electronic Publication: 2008 Sep 12.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Models, Genetic*
Recombination, Genetic*
HIV-1/*genetics
Computational Biology ; Evolution, Molecular ; Genes, env ; Genetic Variation ; Genome, Viral ; HIV Infections/virology ; Humans ; Models, Statistical ; RNA, Viral/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Escape of HIV-1 from a small molecule CCR5 inhibitor is not associated with a fitness loss.
Autorzy:
Anastassopoulou CG; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York, United States of America.
Marozsan AJ
Matet A
Snyder AD
Arts EJ
Kuhmann SE
Moore JP
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Źródło:
PLoS pathogens [PLoS Pathog] 2007 Jun; Vol. 3 (6), pp. e79.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
CCR5 Receptor Antagonists*
Adaptation, Physiological/*drug effects
Anti-HIV Agents/*pharmacology
Drug Resistance, Viral/*drug effects
HIV-1/*drug effects
Niacinamide/*analogs & derivatives
Piperazines/*pharmacology
Adaptation, Physiological/genetics ; Base Sequence ; Cells, Cultured ; Drug Resistance, Viral/genetics ; HIV-1/genetics ; HIV-1/growth & development ; Humans ; Leukocytes, Mononuclear/virology ; Molecular Sequence Data ; Niacinamide/pharmacology ; Receptors, CCR5/metabolism ; Virus Replication/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Is HIV-1 evolving to a less virulent form in humans?
Autorzy:
Ariën KK; HIV and Retrovirology Research Unit, Department of Microbiology, Institute of Tropical Medicine, Nationalestraat 155, B2000 Antwerp, Belgium.
Vanham G
Arts EJ
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Źródło:
Nature reviews. Microbiology [Nat Rev Microbiol] 2007 Feb; Vol. 5 (2), pp. 141-51. Date of Electronic Publication: 2007 Jan 04.
Typ publikacji:
Recenzja
MeSH Terms:
Disease Outbreaks*
Evolution, Molecular*
HIV Infections/*epidemiology
HIV Infections/*virology
HIV-1/*classification
HIV-1/*pathogenicity
Animals ; HIV Infections/physiopathology ; HIV-1/genetics ; Humans ; Phylogeny ; Viral Load ; Virulence ; Virus Replication
Recenzja
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Influence of sequence identity and unique breakpoints on the frequency of intersubtype HIV-1 recombination.
Autorzy:
Baird HA; Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA. heather_ />Gao Y
Galetto R
Lalonde M
Anthony RM
Giacomoni V
Abreha M
Destefano JJ
Negroni M
Arts EJ
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Źródło:
Retrovirology [Retrovirology] 2006 Dec 12; Vol. 3, pp. 91. Date of Electronic Publication: 2006 Dec 12.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Recombination, Genetic*
HIV-1/*genetics
Base Sequence ; Cell Line ; Chromosome Mapping ; Genes, env ; HIV-1/isolation & purification ; HIV-1/physiology ; Humans ; RNA, Viral/chemistry ; Uganda ; Virus Replication
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 32

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