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Wyszukujesz frazę ""Aryl Hydrocarbon Hydroxylases"" wg kryterium: Temat


Tytuł :
Highly homologous mouse Cyp2a4 and Cyp2a5 genes are differentially expressed in the liver and both express long non-coding antisense RNAs.
Autorzy :
Nail AN; Department of Microbiology, Immunology and Molecular Genetics, USA.
Spear BT; Department of Microbiology, Immunology and Molecular Genetics, USA; Markey Cancer Center, University of Kentucky College of Medicine, Lexington, KY 40536, USA.
Peterson ML; Department of Microbiology, Immunology and Molecular Genetics, USA; Markey Cancer Center, University of Kentucky College of Medicine, Lexington, KY 40536, USA. Electronic address: .
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Źródło :
Gene [Gene] 2021 Jan 30; Vol. 767, pp. 145162. Date of Electronic Publication: 2020 Sep 25.
Typ publikacji :
Journal Article
MeSH Terms :
Aryl Hydrocarbon Hydroxylases/*genetics
Cytochrome P450 Family 2/*genetics
Liver/*metabolism
Steroid Hydroxylases/*genetics
Animals ; Aryl Hydrocarbon Hydroxylases/metabolism ; Cytochrome P-450 Enzyme System/genetics ; Cytochrome P450 Family 2/metabolism ; Female ; Gene Expression Regulation/genetics ; Male ; Mice ; Mice, Inbred C57BL ; Protein Binding ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; RNA, Messenger/genetics ; Steroid Hydroxylases/metabolism
Czasopismo naukowe
Tytuł :
[The Effect of CYP 4 F 2 Polymorphism on Initial Warfarin Dose in Patients with Heart Valve Replacement].
Autorzy :
Wang MY; Clinical Medicine Postdoctoral Research Station, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China.; Department of Cardiac Surgery, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China.
Zhu T; Department of Cardiac Surgery, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China.
Yu GJ; Department of Cardiac Surgery, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China.
Huo Q; Department of Cardiac Surgery, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China.
Yang YN; Department of Cardiology, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China.
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Źródło :
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition [Sichuan Da Xue Xue Bao Yi Xue Ban] 2021 Jan; Vol. 52 (1), pp. 129-133.
Typ publikacji :
Journal Article
MeSH Terms :
Aryl Hydrocarbon Hydroxylases*/genetics
Warfarin*/therapeutic use
Anticoagulants/therapeutic use ; Cytochrome P-450 CYP2C9/genetics ; Genotype ; Heart Valves ; Humans ; International Normalized Ratio ; Polymorphism, Genetic ; Vitamin K Epoxide Reductases/genetics
Czasopismo naukowe
Tytuł :
The Influence of Tobacco Smoke/Nicotine on CYP2A Expression in Human and African Green Monkey Lungs.
Autorzy :
Gao Y; Department of Pharmacology and Toxicology, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH) (Y.G., S.M., R.F.T.) and Department of Psychiatry (R.F.T.), University of Toronto, Toronto, Ontario, Canada and Department of Psychiatry and Human Genetics, McGill University, Montreal, Quebec, Canada (R.M.P.).
Miksys S; Department of Pharmacology and Toxicology, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH) (Y.G., S.M., R.F.T.) and Department of Psychiatry (R.F.T.), University of Toronto, Toronto, Ontario, Canada and Department of Psychiatry and Human Genetics, McGill University, Montreal, Quebec, Canada (R.M.P.).
Palmour RM; Department of Pharmacology and Toxicology, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH) (Y.G., S.M., R.F.T.) and Department of Psychiatry (R.F.T.), University of Toronto, Toronto, Ontario, Canada and Department of Psychiatry and Human Genetics, McGill University, Montreal, Quebec, Canada (R.M.P.).
Tyndale RF; Department of Pharmacology and Toxicology, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH) (Y.G., S.M., R.F.T.) and Department of Psychiatry (R.F.T.), University of Toronto, Toronto, Ontario, Canada and Department of Psychiatry and Human Genetics, McGill University, Montreal, Quebec, Canada (R.M.P.) .
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Źródło :
Molecular pharmacology [Mol Pharmacol] 2020 Dec; Vol. 98 (6), pp. 658-668. Date of Electronic Publication: 2020 Oct 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Aryl Hydrocarbon Hydroxylases/*metabolism
Lung/*pathology
Smoking/*pathology
Steroid Hydroxylases/*metabolism
Tobacco Smoke Pollution/*adverse effects
Animals ; Aryl Hydrocarbon Hydroxylases/analysis ; Aryl Hydrocarbon Hydroxylases/genetics ; Chlorocebus aethiops ; Datasets as Topic ; Disease Models, Animal ; Gene Expression Profiling ; Humans ; Lung/drug effects ; Lung Neoplasms/etiology ; Lung Neoplasms/pathology ; Lung Neoplasms/prevention & control ; Male ; Microsomes, Liver ; Nicotine/toxicity ; Non-Smokers ; RNA, Messenger/analysis ; Sequence Analysis, RNA ; Smoke/adverse effects ; Smokers ; Smoking/adverse effects ; Steroid Hydroxylases/analysis ; Steroid Hydroxylases/genetics ; Tobacco/chemistry ; Tobacco/toxicity
Czasopismo naukowe
Tytuł :
Cytochrome P450 4B1 (CYP4B1) as a target in cancer treatment.
Autorzy :
Lim S; Division of Biomedical Science, School of Pharmacy, University of Nottingham Malaysia, Selangor, Malaysia.
Alshagga M; Division of Biomedical Science, School of Pharmacy, University of Nottingham Malaysia, Selangor, Malaysia.
Ong CE; School of Pharmacy, International Medical University, Kuala Lumpur, Malaysia.
Chieng JY; Hospital Pantai Ampang, Kuala Lumpur, Malaysia.
Pan Y; Division of Biomedical Science, School of Pharmacy, University of Nottingham Malaysia, Selangor, Malaysia.
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Źródło :
Human & experimental toxicology [Hum Exp Toxicol] 2020 Jun; Vol. 39 (6), pp. 785-796. Date of Electronic Publication: 2020 Feb 13.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Aryl Hydrocarbon Hydroxylases/*genetics
Neoplasms/*genetics
Animals ; Aryl Hydrocarbon Hydroxylases/metabolism ; Catalysis ; Genes, Transgenic, Suicide ; Humans ; Neoplasms/metabolism
Czasopismo naukowe
Tytuł :
[Verification of accuracy of warfarin stable dose prediction models in Shandong population].
Autorzy :
Ge Y; Qingdao Fuwai Cardiovascular Hospital, Qingdao, Shandong 266034, China. .
Qu F
Wang S
Guo X
Wang C
Liu S
Ma A
Jiang X
Tan K
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Źródło :
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics [Zhonghua Yi Xue Yi Chuan Xue Za Zhi] 2020 Apr 10; Vol. 37 (4), pp. 401-404.
Typ publikacji :
Journal Article
MeSH Terms :
Aryl Hydrocarbon Hydroxylases*
Anticoagulants/*administration & dosage
Warfarin/*administration & dosage
Cytochrome P-450 CYP2C9/genetics ; Cytochrome P450 Family 4/genetics ; Dose-Response Relationship, Drug ; Genotype ; Humans ; Models, Theoretical ; Polymorphism, Genetic ; Vitamin K Epoxide Reductases/genetics
Czasopismo naukowe
Tytuł :
Regulation of bile acid metabolism in mouse models with hydrophobic bile acid composition.
Autorzy :
Honda A; Joint Research Center, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan .; Department of Gastroenterology and Hepatology, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan.
Miyazaki T; Joint Research Center, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan.
Iwamoto J; Department of Gastroenterology and Hepatology, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan.
Hirayama T; Department of Gastroenterology and Hepatology, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan.
Morishita Y; Diagnostic Pathology Division, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan.
Monma T; Department of Gastroenterology and Hepatology, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan.
Ueda H; Department of Gastroenterology and Hepatology, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan.
Mizuno S; Laboratory Animal Resource Center, University of Tsukuba, Ibaraki, Japan.
Sugiyama F; Laboratory Animal Resource Center, University of Tsukuba, Ibaraki, Japan.
Takahashi S; Laboratory Animal Resource Center, University of Tsukuba, Ibaraki, Japan.
Ikegami T; Department of Gastroenterology and Hepatology, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan.
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Źródło :
Journal of lipid research [J Lipid Res] 2020 Jan; Vol. 61 (1), pp. 54-69. Date of Electronic Publication: 2019 Oct 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Models, Animal*
Aryl Hydrocarbon Hydroxylases/*genetics
Bile Acids and Salts/*metabolism
Cytochrome P-450 Enzyme System/*genetics
Steroid Hydroxylases/*genetics
Animals ; Aryl Hydrocarbon Hydroxylases/deficiency ; Aryl Hydrocarbon Hydroxylases/metabolism ; Bile Acids and Salts/chemistry ; Chenodeoxycholic Acid/chemistry ; Chenodeoxycholic Acid/metabolism ; Cytochrome P-450 Enzyme System/deficiency ; Cytochrome P-450 Enzyme System/metabolism ; Female ; Hydrophobic and Hydrophilic Interactions ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Molecular Structure ; Rats ; Rats, Sprague-Dawley ; Steroid Hydroxylases/deficiency ; Steroid Hydroxylases/metabolism
Czasopismo naukowe
Tytuł :
Novel insights into oxidation of fatty acids and fatty alcohols by cytochrome P450 monooxygenase CYP4B1.
Autorzy :
Thesseling FA; Institute of Biochemistry, Heinrich-Heine University, 40225, Düsseldorf, Germany. Electronic address: .
Hutter MC; Center for Bioinformatics, Saarland University, 66123, Saarbrücken, Germany. Electronic address: .
Wiek C; Department of Otorhinolaryngology and Head/Neck Surgery, Heinrich-Heine University, 40225, Düsseldorf, Germany. Electronic address: .
Kowalski JP; Department of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, WA, 98195, USA. Electronic address: .
Rettie AE; Department of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, WA, 98195, USA. Electronic address: .
Girhard M; Institute of Biochemistry, Heinrich-Heine University, 40225, Düsseldorf, Germany. Electronic address: .
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Źródło :
Archives of biochemistry and biophysics [Arch Biochem Biophys] 2020 Jan 15; Vol. 679, pp. 108216. Date of Electronic Publication: 2019 Dec 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Aryl Hydrocarbon Hydroxylases/*metabolism
Fatty Acids/*metabolism
Fatty Alcohols/*metabolism
Aryl Hydrocarbon Hydroxylases/chemistry ; Cytochromes b5/metabolism ; Humans ; Kinetics ; Molecular Docking Simulation ; Oxidation-Reduction ; Protein Conformation
Czasopismo naukowe
Tytuł :
Pharmacogenomics of poor drug metabolism in Greyhounds: Cytochrome P450 (CYP) 2B11 genetic variation, breed distribution, and functional characterization.
Autorzy :
Martinez SE; Comparative Pharmacogenomics Laboratory, Program in Individualized Medicine (PrIMe), Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, Washington, United States of America. .
Andresen MC; Comparative Pharmacogenomics Laboratory, Program in Individualized Medicine (PrIMe), Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, Washington, United States of America.
Zhu Z; Comparative Pharmacogenomics Laboratory, Program in Individualized Medicine (PrIMe), Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, Washington, United States of America.
Papageorgiou I; Comparative Pharmacogenomics Laboratory, Program in Individualized Medicine (PrIMe), Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, Washington, United States of America.; Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, Diabetes Institute, University of Florida, Gainesville, Florida, United States of America.
Court MH; Comparative Pharmacogenomics Laboratory, Program in Individualized Medicine (PrIMe), Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, Washington, United States of America.
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Źródło :
Scientific reports [Sci Rep] 2020 Jan 09; Vol. 10 (1), pp. 69. Date of Electronic Publication: 2020 Jan 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Genetic Variation*
Aryl Hydrocarbon Hydroxylases/*metabolism
Cytochrome P450 Family 2/*metabolism
Pharmacogenetics/*methods
Steroid Hydroxylases/*metabolism
3' Untranslated Regions ; Alleles ; Anesthetics, Intravenous/metabolism ; Animals ; Aryl Hydrocarbon Hydroxylases/genetics ; Breeding ; Cytochrome P450 Family 2/genetics ; Dogs ; Gene Frequency ; Haplotypes ; Linkage Disequilibrium ; Liver/enzymology ; Liver/metabolism ; Microsomes, Liver/metabolism ; Propofol/metabolism ; RNA Splicing ; Recombinant Proteins/biosynthesis ; Recombinant Proteins/isolation & purification ; Steroid Hydroxylases/genetics
Czasopismo naukowe
Tytuł :
Nurse empowerment through Pharmacogenetics.
Autorzy :
Moraes JC; Hospital das Clínicas de Ribeirão Preto, Ribeirão Preto, SP, Brazil.
Nunes FDD; Escola de Enfermagem de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.
Coeli-Lacchini FB; Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.
Miyazaki AHL; GASEO Medicina Ocupacional, Ribeirão Preto, SP, Brazil.
Flória-Santos M; Escola de Enfermagem de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.
Lacchini R; Escola de Enfermagem de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.
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Źródło :
Revista latino-americana de enfermagem [Rev Lat Am Enfermagem] 2020; Vol. 28, pp. e3265. Date of Electronic Publication: 2020 Aug 12.
Typ publikacji :
Journal Article
MeSH Terms :
Aryl Hydrocarbon Hydroxylases*
Pharmacogenetics*
Brazil ; Cross-Sectional Studies ; Cytochrome P-450 CYP2C9/genetics ; Empowerment ; Humans
Czasopismo naukowe
Tytuł :
Structure-Activity Relationships for CYP4B1 Bioactivation of 4-Ipomeanol Congeners: Direct Correlation between Cytotoxicity and Trapped Reactive Intermediates.
Autorzy :
Kowalski JP; Department of Medicinal Chemistry, School of Pharmacy , University of Washington , Seattle , Washington 98105 , United States.
McDonald MG; Department of Medicinal Chemistry, School of Pharmacy , University of Washington , Seattle , Washington 98105 , United States.
Whittington D; Department of Medicinal Chemistry, School of Pharmacy , University of Washington , Seattle , Washington 98105 , United States.
Guttman M; Department of Medicinal Chemistry, School of Pharmacy , University of Washington , Seattle , Washington 98105 , United States.
Scian M; Department of Medicinal Chemistry, School of Pharmacy , University of Washington , Seattle , Washington 98105 , United States.
Girhard M; Institute of Biochemistry , Heinrich-Heine University , 40225 Düsseldorf , Germany.
Hanenberg H; Department of Pediatrics III, University Children's Hospital Essen , University of Duisburg-Essen , 45122 Essen , Germany.
Wiek C; Department of Otorhinolaryngology and Head/Neck Surgery , Heinrich-Heine University , 40225 Düsseldorf , Germany.
Rettie AE; Department of Medicinal Chemistry, School of Pharmacy , University of Washington , Seattle , Washington 98105 , United States.
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Źródło :
Chemical research in toxicology [Chem Res Toxicol] 2019 Dec 16; Vol. 32 (12), pp. 2488-2498. Date of Electronic Publication: 2019 Dec 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Amides/*toxicity
Aryl Hydrocarbon Hydroxylases/*metabolism
Furans/*toxicity
Activation, Metabolic ; Amides/chemical synthesis ; Amides/metabolism ; Animals ; Aryl Hydrocarbon Hydroxylases/antagonists & inhibitors ; Aryl Hydrocarbon Hydroxylases/chemistry ; Catalytic Domain ; Cytochrome P-450 Enzyme Inhibitors/chemical synthesis ; Cytochrome P-450 Enzyme Inhibitors/metabolism ; Cytochrome P-450 Enzyme Inhibitors/toxicity ; Furans/chemical synthesis ; Furans/metabolism ; Hep G2 Cells ; Humans ; Hydroxylation ; Kinetics ; Molecular Docking Simulation ; Molecular Structure ; Protein Binding ; Rabbits ; Structure-Activity Relationship ; Terpenes/chemistry ; Terpenes/toxicity
Czasopismo naukowe
Tytuł :
High Dietary Kuding Tea Extract Supplementation Induces Hepatic Xenobiotic-Metabolizing Enzymes-A 6-Week Feeding Study in Mice.
Autorzy :
Wüpper S; Institute of Human Nutrition and Food Science, University of Kiel, Hermann-Rodewald-Strasse 6, 24118 Kiel, Germany.
Fischer A; Institute of Human Nutrition and Food Science, University of Kiel, Hermann-Rodewald-Strasse 6, 24118 Kiel, Germany.
Lüersen K; Institute of Human Nutrition and Food Science, University of Kiel, Hermann-Rodewald-Strasse 6, 24118 Kiel, Germany.
Lucius R; Anatomical Institute, University of Kiel, Otto-Hahn Platz 8, 24118 Kiel, Germany.
Okamoto H; CycloChem Bio Co., Ltd., 7-4-5 Minatojima-minamimachi, Chuo-ku, Kobe 650-0047, Japan.
Ishida Y; CycloChem Bio Co., Ltd., 7-4-5 Minatojima-minamimachi, Chuo-ku, Kobe 650-0047, Japan.
Terao K; CycloChem Bio Co., Ltd., 7-4-5 Minatojima-minamimachi, Chuo-ku, Kobe 650-0047, Japan.
Rimbach G; Institute of Human Nutrition and Food Science, University of Kiel, Hermann-Rodewald-Strasse 6, 24118 Kiel, Germany.
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Źródło :
Nutrients [Nutrients] 2019 Dec 22; Vol. 12 (1). Date of Electronic Publication: 2019 Dec 22.
Typ publikacji :
Journal Article
MeSH Terms :
Aryl Hydrocarbon Hydroxylases/*metabolism
Enzyme Induction/*drug effects
Liver/*enzymology
Plant Extracts/*pharmacology
Tea/*chemistry
Adipose Tissue ; Animals ; Aryl Hydrocarbon Hydroxylases/genetics ; Body Composition/drug effects ; Camellia sinensis/chemistry ; Dietary Supplements ; Hep G2 Cells ; Humans ; Liver/anatomy & histology ; Male ; Mice ; Mice, Inbred C57BL ; Organ Size ; Plant Extracts/chemistry
Czasopismo naukowe
Tytuł :
Metabolism of Benzalkonium Chlorides by Human Hepatic Cytochromes P450.
Autorzy :
Seguin RP; Department of Medicinal Chemistry, School of Pharmacy , University of Washington , Seattle , Washington 98195 , United States.
Herron JM; Department of Environmental and Occupational Health Sciences, School of Public Health , University of Washington , Seattle , Washington 98195 , United States.
Lopez VA; Department of Medicinal Chemistry, School of Pharmacy , University of Washington , Seattle , Washington 98195 , United States.
Dempsey JL; Department of Environmental and Occupational Health Sciences, School of Public Health , University of Washington , Seattle , Washington 98195 , United States.
Xu L; Department of Medicinal Chemistry, School of Pharmacy , University of Washington , Seattle , Washington 98195 , United States.; Department of Environmental and Occupational Health Sciences, School of Public Health , University of Washington , Seattle , Washington 98195 , United States.
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Źródło :
Chemical research in toxicology [Chem Res Toxicol] 2019 Dec 16; Vol. 32 (12), pp. 2466-2478. Date of Electronic Publication: 2019 Dec 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Aryl Hydrocarbon Hydroxylases/*metabolism
Benzalkonium Compounds/*metabolism
Cytochrome P-450 CYP2D6/*metabolism
Cytochrome P-450 CYP3A/*metabolism
Disinfectants/*metabolism
Amidines/pharmacology ; Animals ; Aryl Hydrocarbon Hydroxylases/chemistry ; Benzalkonium Compounds/chemistry ; Carbon Isotopes/chemistry ; Cytochrome P-450 CYP2D6/chemistry ; Cytochrome P-450 CYP2D6 Inhibitors/pharmacology ; Cytochrome P-450 CYP3A/chemistry ; Cytochrome P-450 CYP3A Inhibitors/pharmacology ; Female ; Humans ; Hydroxylation/drug effects ; Kinetics ; Male ; Mice ; Microsomes, Liver/metabolism ; Oxidation-Reduction ; Quinidine/pharmacology
Czasopismo naukowe
Tytuł :
Effects of CYP2C11 gene knockout on the pharmacokinetics and pharmacodynamics of warfarin in rats.
Autorzy :
Ye H; School of Pharmacy, Jiangsu University , Zhenjiang , PR China.
Sui D; School of Pharmacy, Jiangsu University , Zhenjiang , PR China.
Liu W; School of Pharmacy, Jiangsu University , Zhenjiang , PR China.
Yuan Y; School of Pharmacy, Jiangsu University , Zhenjiang , PR China.
Ouyang Z; School of Pharmacy, Jiangsu University , Zhenjiang , PR China.
Wei Y; School of Pharmacy, Jiangsu University , Zhenjiang , PR China.
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Źródło :
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2019 Dec; Vol. 49 (12), pp. 1478-1484. Date of Electronic Publication: 2019 Feb 27.
Typ publikacji :
Journal Article; Video-Audio Media
MeSH Terms :
Aryl Hydrocarbon Hydroxylases/*genetics
Cytochrome P450 Family 2/*genetics
Steroid 16-alpha-Hydroxylase/*genetics
Warfarin/*pharmacokinetics
Animals ; Anticoagulants/pharmacokinetics ; Aryl Hydrocarbon Hydroxylases/metabolism ; Cytochrome P450 Family 2/metabolism ; Female ; Gene Knockout Techniques ; Male ; Microsomes, Liver/drug effects ; Microsomes, Liver/metabolism ; Rats, Sprague-Dawley ; Steroid 16-alpha-Hydroxylase/metabolism
Czasopismo naukowe
Tytuł :
Toxicokinetic Interaction between Hepatic Disposition and Pulmonary Bioactivation of Inhaled Naphthalene Studied Using Cyp2abfgs -Null and CYP2A13/2F1-Humanized Mice with Deficient Hepatic Cytochrome P450 Activity.
Autorzy :
Kovalchuk N; Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona (N.K., Q.-Y.Z., X.D.); Wadsworth Center, New York State Department of Health, and School of Public Health, State University of New York, Albany, New York (N.K., Q.-Y.Z.); Center for Health and the Environment, Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California, Davis, California (J.K., L.V.W.); and College of Nanoscale Science, State University of New York Polytechnic Institute, Albany, New York (X.D.).
Zhang QY; Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona (N.K., Q.-Y.Z., X.D.); Wadsworth Center, New York State Department of Health, and School of Public Health, State University of New York, Albany, New York (N.K., Q.-Y.Z.); Center for Health and the Environment, Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California, Davis, California (J.K., L.V.W.); and College of Nanoscale Science, State University of New York Polytechnic Institute, Albany, New York (X.D.).
Kelty J; Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona (N.K., Q.-Y.Z., X.D.); Wadsworth Center, New York State Department of Health, and School of Public Health, State University of New York, Albany, New York (N.K., Q.-Y.Z.); Center for Health and the Environment, Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California, Davis, California (J.K., L.V.W.); and College of Nanoscale Science, State University of New York Polytechnic Institute, Albany, New York (X.D.).
Van Winkle L; Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona (N.K., Q.-Y.Z., X.D.); Wadsworth Center, New York State Department of Health, and School of Public Health, State University of New York, Albany, New York (N.K., Q.-Y.Z.); Center for Health and the Environment, Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California, Davis, California (J.K., L.V.W.); and College of Nanoscale Science, State University of New York Polytechnic Institute, Albany, New York (X.D.) .
Ding X; Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona (N.K., Q.-Y.Z., X.D.); Wadsworth Center, New York State Department of Health, and School of Public Health, State University of New York, Albany, New York (N.K., Q.-Y.Z.); Center for Health and the Environment, Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California, Davis, California (J.K., L.V.W.); and College of Nanoscale Science, State University of New York Polytechnic Institute, Albany, New York (X.D.) .
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Źródło :
Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2019 Dec; Vol. 47 (12), pp. 1469-1478. Date of Electronic Publication: 2019 Oct 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Aryl Hydrocarbon Hydroxylases/*metabolism
Cytochrome P450 Family 2/*metabolism
Inhalation Exposure/*adverse effects
Liver/*metabolism
Lung/*metabolism
Naphthalenes/*pharmacokinetics
Naphthalenes/*toxicity
Animals ; Aryl Hydrocarbon Hydroxylases/genetics ; Biological Availability ; Cytochrome P450 Family 2/genetics ; Female ; Humans ; Liver/enzymology ; Male ; Mice ; Mice, Knockout ; Mice, Transgenic ; Naphthalenes/blood ; Tissue Distribution ; Toxicokinetics
Czasopismo naukowe
Tytuł :
Validation of an HPLC Method for the Simultaneous Quantification of Metabolic Reaction Products Catalysed by CYP2C11 Enzymes in Rat Liver Microsomes: In Vitro Inhibitory Effect of Salicylic Acid on CYP2C11 Enzyme.
Autorzy :
Salhab H; School of Life Sciences, Pharmacy and Chemistry, Kingston University, Kingston upon Thames, London KT1 2EE, UK.
Naughton DP; School of Life Sciences, Pharmacy and Chemistry, Kingston University, Kingston upon Thames, London KT1 2EE, UK.
Barker J; School of Life Sciences, Pharmacy and Chemistry, Kingston University, Kingston upon Thames, London KT1 2EE, UK.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2019 Nov 25; Vol. 24 (23). Date of Electronic Publication: 2019 Nov 25.
Typ publikacji :
Journal Article
MeSH Terms :
Aryl Hydrocarbon Hydroxylases/*antagonists & inhibitors
Cytochrome P-450 Enzyme Inhibitors/*pharmacology
Cytochrome P450 Family 2/*antagonists & inhibitors
Liver/*drug effects
Salicylic Acid/*pharmacology
Steroid 16-alpha-Hydroxylase/*antagonists & inhibitors
Animals ; Aryl Hydrocarbon Hydroxylases/chemistry ; Catalysis ; Chromatography, High Pressure Liquid ; Cytochrome P-450 Enzyme Inhibitors/chemistry ; Cytochrome P450 Family 2/chemistry ; Drug Development ; Humans ; Liver/enzymology ; Rats ; Salicylic Acid/chemistry ; Steroid 16-alpha-Hydroxylase/chemistry
Czasopismo naukowe
Tytuł :
Regioselective hydroxylation of an antiarrhythmic drug, propafenone, mediated by rat liver cytochrome P450 2D2 differs from that catalyzed by human P450 2D6.
Autorzy :
Uehara S; a Central Institute for Experimental Animals , Kawasaki , Japan.
Murayama N; b Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University , Machida , Japan.
Yamazaki H; b Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University , Machida , Japan.
Suemizu H; a Central Institute for Experimental Animals , Kawasaki , Japan.
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Źródło :
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2019 Nov; Vol. 49 (11), pp. 1323-1331. Date of Electronic Publication: 2019 Jun 14.
Typ publikacji :
Journal Article; Video-Audio Media
MeSH Terms :
Aryl Hydrocarbon Hydroxylases/*metabolism
Cytochrome P-450 CYP2D6/*metabolism
Microsomes, Liver/*metabolism
Propafenone/*pharmacokinetics
Adult ; Aged ; Animals ; Anti-Arrhythmia Agents/chemistry ; Anti-Arrhythmia Agents/metabolism ; Anti-Arrhythmia Agents/pharmacokinetics ; Aryl Hydrocarbon Hydroxylases/chemistry ; Callithrix ; Cytochrome P-450 CYP2D6/chemistry ; Cytochrome P-450 Enzyme Inhibitors/pharmacology ; Dogs ; Female ; Humans ; Hydroxylation ; Macaca fascicularis ; Male ; Mice, Inbred Strains ; Microsomes, Liver/drug effects ; Middle Aged ; Propafenone/chemistry ; Propafenone/metabolism ; Rats, Sprague-Dawley ; Species Specificity ; Swine ; Swine, Miniature
Czasopismo naukowe
Tytuł :
Effect of piperine and quercetin alone or in combination with marbofloxacin on CYP3A37 and MDR1 mRNA expression levels in broiler chickens.
Autorzy :
Patel HB; Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Junagadh Agricultural University, Junagadh 362001, Gujarat, India. Electronic address: .
Patel UD; Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Junagadh Agricultural University, Junagadh 362001, Gujarat, India.
Mathapati BS; Department of Veterinary Microbiology, College of Veterinary Science and Animal Husbandry, Junagadh Agricultural University, Junagadh 362001, Gujarat, India.
Modi CM; Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Junagadh Agricultural University, Junagadh 362001, Gujarat, India.
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Źródło :
Research in veterinary science [Res Vet Sci] 2019 Oct; Vol. 126, pp. 178-183. Date of Electronic Publication: 2019 Sep 12.
Typ publikacji :
Journal Article
MeSH Terms :
ATP Binding Cassette Transporter, Subfamily B, Member 1/*genetics
Alkaloids/*pharmacology
Aryl Hydrocarbon Hydroxylases/*genetics
Benzodioxoles/*pharmacology
Chickens/*physiology
Cytochrome P450 Family 3/*genetics
Fluoroquinolones/*pharmacology
Gene Expression Regulation/*drug effects
Piperidines/*pharmacology
Polyunsaturated Alkamides/*pharmacology
Quercetin/*pharmacology
ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism ; Animals ; Anti-Bacterial Agents/pharmacology ; Antioxidants/pharmacology ; Aryl Hydrocarbon Hydroxylases/metabolism ; Avian Proteins/genetics ; Avian Proteins/metabolism ; Chickens/genetics ; Cytochrome P-450 Enzyme Inhibitors/pharmacology ; Cytochrome P450 Family 3/metabolism ; Duodenum/drug effects ; Duodenum/metabolism ; Liver/drug effects ; Liver/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Random Allocation
Czasopismo naukowe
Tytuł :
CYP4BN6 and CYP6BQ11 mediate insecticide susceptibility and their expression is regulated by Latrophilin in Tribolium castaneum.
Autorzy :
Xiong W; Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, China.
Gao S; Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, China.; College of Biology and Food Engineering, Anyang Institute of Technology, Anyang, China.
Mao J; Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, China.
Wei L; Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, China.
Xie J; Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, China.
Liu J; Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, China.
Bi J; Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, China.
Song X; Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, China.
Li B; Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, China.
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Źródło :
Pest management science [Pest Manag Sci] 2019 Oct; Vol. 75 (10), pp. 2744-2755. Date of Electronic Publication: 2019 Mar 21.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation*
Aryl Hydrocarbon Hydroxylases/*genetics
Insect Proteins/*genetics
Insecticide Resistance/*genetics
Receptors, Peptide/*metabolism
Tribolium/*genetics
Animals ; Aryl Hydrocarbon Hydroxylases/metabolism ; Insect Proteins/metabolism ; Larva/drug effects ; Larva/metabolism ; Ovum/drug effects ; Pupa/drug effects ; Pupa/metabolism ; Tribolium/drug effects ; Tribolium/growth & development ; Tribolium/metabolism
Czasopismo naukowe
Tytuł :
Association between CYP2A13 polymorphisms and lung cancer: A protocol for systematic review and meta-analysis.
Autorzy :
Ma L; Department of Clinical Medicine, Gansu University of Traditional Chinese Medicine.; Department of Thoracic Surgery, Gansu Provincial Hospital, Lanzhou, China.
Jin G; Department of Thoracic Surgery, Gansu Provincial Hospital, Lanzhou, China.
Yang Y; Department of Clinical Medicine, Gansu University of Traditional Chinese Medicine.; Department of Thoracic Surgery, Gansu Provincial Hospital, Lanzhou, China.
Pang Y; Department of Thoracic Surgery, Gansu Provincial Hospital, Lanzhou, China.
Wang W; Department of Thoracic Surgery, Gansu Provincial Hospital, Lanzhou, China.
Zhang H; Department of Thoracic Surgery, Gansu Provincial Hospital, Lanzhou, China.
Liu J; Department of Thoracic Surgery, Gansu Provincial Hospital, Lanzhou, China.
Wu P; Department of Clinical Medicine, Gansu University of Traditional Chinese Medicine.; Department of Thoracic Surgery, Gansu Provincial Hospital, Lanzhou, China.
Wang Z; Department of Thoracic Surgery, Gansu Provincial Hospital, Lanzhou, China.
Wang K; Department of Clinical Medicine, Gansu University of Traditional Chinese Medicine.; Department of Thoracic Surgery, Gansu Provincial Hospital, Lanzhou, China.
Chang R; Department of Thoracic Surgery, Gansu Provincial Hospital, Lanzhou, China.
Li J; Department of Thoracic Surgery, Gansu Provincial Hospital, Lanzhou, China.
Zhu Z; Department of Thoracic Surgery, Gansu Provincial Hospital, Lanzhou, China.
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Źródło :
Medicine [Medicine (Baltimore)] 2020 Dec 11; Vol. 99 (50), pp. e23289.
Typ publikacji :
Journal Article; Meta-Analysis; Systematic Review
MeSH Terms :
Aryl Hydrocarbon Hydroxylases/*genetics
Genetic Predisposition to Disease/*genetics
Lung Neoplasms/*genetics
Polymorphism, Genetic/*genetics
Humans
Czasopismo naukowe
Tytuł :
High-fat diet induces fibrosis in mice lacking CYP2A5 and PPARα: a new model for steatohepatitis-associated fibrosis.
Autorzy :
Chen X; Department of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, West Virginia.
Acquaah-Mensah GK; Department of Pharmaceutical Sciences, Massachusetts College of Pharmacy and Health Sciences, Worcester, Massachusetts.
Denning KL; Department of Pathology, Joan C. Edwards School of Medicine, Marshall University, Huntington, West Virginia.
Peterson JM; Department of Health Sciences, College of Public Health, East Tennessee State University, Johnson City, Tennessee.
Wang K; Department of Family and Community Health, School of Nursing, Health Sciences Center, West Virginia University, Morgantown, West Virginia.
Denvir J; Department of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, West Virginia.
Hong F; Institute of Liver Diseases, Affiliated Hospital of Jining Medical University, Jining, China.
Cederbaum AI; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York.
Lu Y; Department of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, West Virginia.; Department of Clinical and Translational Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, West Virginia.
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Źródło :
American journal of physiology. Gastrointestinal and liver physiology [Am J Physiol Gastrointest Liver Physiol] 2020 Nov 01; Vol. 319 (5), pp. G626-G635. Date of Electronic Publication: 2020 Sep 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Aryl Hydrocarbon Hydroxylases/*genetics
Cytochrome P450 Family 2/*genetics
Diet, High-Fat/*adverse effects
Liver Cirrhosis/*genetics
Liver Cirrhosis/*pathology
Non-alcoholic Fatty Liver Disease/*genetics
PPAR alpha/*genetics
Animals ; Body Weight ; Lipid Droplets/metabolism ; Lipid Peroxidation ; Liver Cirrhosis/etiology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Non-alcoholic Fatty Liver Disease/complications
Czasopismo naukowe

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