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    Wyświetlanie 1-11 z 11
    Tytuł:
    NOD2 in Crohn's Disease-Unfinished Business.
    Autorzy:
    Ashton JJ; Department of Human Genetics and Genomic Medicine, University of Southampton, Southampton, UK.; Department of Paediatric Gastroenterology, Southampton Children's Hospital, Southampton, UK.
    Seaby EG; Department of Human Genetics and Genomic Medicine, University of Southampton, Southampton, UK.
    Beattie RM; Department of Paediatric Gastroenterology, Southampton Children's Hospital, Southampton, UK.
    Ennis S; Department of Human Genetics and Genomic Medicine, University of Southampton, Southampton, UK.
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    Źródło:
    Journal of Crohn's & colitis [J Crohns Colitis] 2023 Apr 03; Vol. 17 (3), pp. 450-458.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Genome-Wide Association Study*
    Crohn Disease*/diagnosis
    Crohn Disease*/genetics
    Humans ; Phenotype ; Nod2 Signaling Adaptor Protein/genetics ; Genetic Predisposition to Disease
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Evidence of a genetically driven metabolomic signature in actively inflamed Crohn's disease.
    Autorzy:
    Mossotto E; Human Genetics and Genomic Medicine, Southampton General Hospital, University of Southampton, Duthie Building (Mailpoint 808), Southampton, SO16 6YD, UK.; Institute for Life Sciences, University of Southampton, Southampton, UK.; NIHR Southampton Biomedical Research Centre, University Hospital Southampton, Southampton, UK.
    Boberska J; Department of Food and Nutritional Sciences, The University of Reading, Whiteknights campus, Reading, UK.
    Ashton JJ; Human Genetics and Genomic Medicine, Southampton General Hospital, University of Southampton, Duthie Building (Mailpoint 808), Southampton, SO16 6YD, UK.; Department of Paediatric Gastroenterology, Southampton Children's Hospital, Southampton, UK.
    Stafford IS; Human Genetics and Genomic Medicine, Southampton General Hospital, University of Southampton, Duthie Building (Mailpoint 808), Southampton, SO16 6YD, UK.; Institute for Life Sciences, University of Southampton, Southampton, UK.; NIHR Southampton Biomedical Research Centre, University Hospital Southampton, Southampton, UK.
    Cheng G; Human Genetics and Genomic Medicine, Southampton General Hospital, University of Southampton, Duthie Building (Mailpoint 808), Southampton, SO16 6YD, UK.; NIHR Southampton Biomedical Research Centre, University Hospital Southampton, Southampton, UK.
    Baker J; Department of Paediatric Gastroenterology, Southampton Children's Hospital, Southampton, UK.
    Borca F; NIHR Southampton Biomedical Research Centre, University Hospital Southampton, Southampton, UK.
    Phan HTT; NIHR Southampton Biomedical Research Centre, University Hospital Southampton, Southampton, UK.
    Coelho TF; Department of Paediatric Gastroenterology, Southampton Children's Hospital, Southampton, UK.
    Beattie RM; Department of Paediatric Gastroenterology, Southampton Children's Hospital, Southampton, UK.
    Claus SP; Department of Food and Nutritional Sciences, The University of Reading, Whiteknights campus, Reading, UK.
    Ennis S; Human Genetics and Genomic Medicine, Southampton General Hospital, University of Southampton, Duthie Building (Mailpoint 808), Southampton, SO16 6YD, UK. .; Institute for Life Sciences, University of Southampton, Southampton, UK. .; NIHR Southampton Biomedical Research Centre, University Hospital Southampton, Southampton, UK. .
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    Źródło:
    Scientific reports [Sci Rep] 2022 Aug 18; Vol. 12 (1), pp. 14101. Date of Electronic Publication: 2022 Aug 18.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Colitis, Ulcerative*/pathology
    Crohn Disease*/pathology
    Inflammatory Bowel Diseases*/pathology
    Child ; Humans ; Inflammation/genetics ; Metabolome/genetics ; Metabolomics
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Ileal Transcriptomic Analysis in Paediatric Crohn's Disease Reveals IL17- and NOD-signalling Expression Signatures in Treatment-naïve Patients and Identifies Epithelial Cells Driving Differentially Expressed Genes.
    Autorzy:
    Ashton JJ; Department of Human Genetics and Genomic Medicine, University of Southampton, Southampton, UK.; Department of Paediatric Gastroenterology, Southampton Children's Hospital, Southampton, UK.
    Boukas K; Wessex Investigational Sciences Hub, University of Southampton Faculty of Medicine, Southampton General Hospital, Southampton, UK.
    Davies J; Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, Faculty of Medicine, University of Southampton, Southampton, UK.
    Stafford IS; Department of Human Genetics and Genomic Medicine, University of Southampton, Southampton, UK.; Institute for Life Sciences, University of Southampton, Southampton, UK.
    Vallejo AF; Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, Faculty of Medicine, University of Southampton, Southampton, UK.
    Haggarty R; NIHR Southampton Biomedical Research Centre, University Hospital Southampton, Southampton, UK.
    Coelho TAF; Department of Paediatric Gastroenterology, Southampton Children's Hospital, Southampton, UK.
    Batra A; Department of Paediatric Gastroenterology, Southampton Children's Hospital, Southampton, UK.
    Afzal NA; Department of Paediatric Gastroenterology, Southampton Children's Hospital, Southampton, UK.
    Vadgama B; Department of Paediatric Histopathology, Southampton Children's Hospital, Southampton, UK.
    Williams AP; Wessex Investigational Sciences Hub, University of Southampton Faculty of Medicine, Southampton General Hospital, Southampton, UK.; Institute for Life Sciences, University of Southampton, Southampton, UK.
    Beattie RM; Department of Paediatric Gastroenterology, Southampton Children's Hospital, Southampton, UK.
    Polak ME; Department of Human Genetics and Genomic Medicine, University of Southampton, Southampton, UK.; Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, Faculty of Medicine, University of Southampton, Southampton, UK.
    Ennis S; Department of Human Genetics and Genomic Medicine, University of Southampton, Southampton, UK.
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    Źródło:
    Journal of Crohn's & colitis [J Crohns Colitis] 2021 May 04; Vol. 15 (5), pp. 774-786.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Crohn Disease/*genetics
    Epithelial Cells/*metabolism
    Gene Expression Profiling/*methods
    Ileum/*metabolism
    Interleukin-17/*genetics
    Nod2 Signaling Adaptor Protein/*genetics
    Adolescent ; Biopsy ; Child ; Crohn Disease/drug therapy ; Female ; Gastrointestinal Agents/therapeutic use ; Humans ; Male ; Signal Transduction ; Th17 Cells/metabolism
    SCR Disease Name:
    Pediatric Crohn's disease
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Expression profile of the matricellular protein periostin in paediatric inflammatory bowel disease.
    Autorzy:
    Coelho T; Human Genetics and Genomic Medicine, University of Southampton, Southampton, UK.; Department of Paediatric Gastroenterology, University Hospital Southampton, Southampton, UK.
    Sonnenberg-Riethmacher E; Department of Biomedical Sciences, Nazarbayev University School of Medicine, Nur-Sultan, Republic of Kazakhstan.; Academic Unit of Human Development and Health, University of Southampton, Southampton, UK.
    Gao Y; Cancer Sciences Division, Faculty of Medicine, University Hospital Southampton, Southampton, UK.; Organ Transplantation Center, The First Affiliated Hospital, Sun Yatsen University, Guangzhou, China.
    Mossotto E; Human Genetics and Genomic Medicine, University of Southampton, Southampton, UK.
    Khojanazarov A; Department of Biomedical Sciences, Nazarbayev University School of Medicine, Nur-Sultan, Republic of Kazakhstan.
    Griffin A; Cancer Sciences Division, Faculty of Medicine, University Hospital Southampton, Southampton, UK.
    Mukanova S; Department of Biomedical Sciences, Nazarbayev University School of Medicine, Nur-Sultan, Republic of Kazakhstan.
    Ashimkhanova A; Department of Biomedical Sciences, Nazarbayev University School of Medicine, Nur-Sultan, Republic of Kazakhstan.
    Haggarty R; Southampton Biomedical Research Centre, NIHR, University Hospital Southampton, Southampton, UK.
    Borissenko A; Department of Biomedical Sciences, Nazarbayev University School of Medicine, Nur-Sultan, Republic of Kazakhstan.
    Ashton JJ; Human Genetics and Genomic Medicine, University of Southampton, Southampton, UK.; Department of Paediatric Gastroenterology, University Hospital Southampton, Southampton, UK.
    Stafford IS; Human Genetics and Genomic Medicine, University of Southampton, Southampton, UK.
    Batra A; Department of Paediatric Gastroenterology, University Hospital Southampton, Southampton, UK.
    Afzal NA; Department of Paediatric Gastroenterology, University Hospital Southampton, Southampton, UK.
    Stanton MP; Department of Paediatric Surgery, University Hospital Southampton, Southampton, UK.
    Vadgama B; Department of Pathology, University Hospital Southampton, Southampton, UK.
    Adrisova K; National Research Center for Maternal and Child Health, Nur-Sultan, Republic of Kazakhstan.
    Beattie RM; Department of Paediatric Gastroenterology, University Hospital Southampton, Southampton, UK.
    Williams AP; Cancer Sciences Division, Faculty of Medicine, University Hospital Southampton, Southampton, UK.
    Ennis S; Human Genetics and Genomic Medicine, University of Southampton, Southampton, UK.
    Riethmacher D; Department of Biomedical Sciences, Nazarbayev University School of Medicine, Nur-Sultan, Republic of Kazakhstan. .; Academic Unit of Human Development and Health, University of Southampton, Southampton, UK. .
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    Źródło:
    Scientific reports [Sci Rep] 2021 Mar 18; Vol. 11 (1), pp. 6194. Date of Electronic Publication: 2021 Mar 18.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Gene Regulatory Networks*
    Cell Adhesion Molecules/*genetics
    Colitis, Ulcerative/*genetics
    Colon/*metabolism
    Crohn Disease/*genetics
    Intestinal Mucosa/*metabolism
    Adolescent ; Adult ; Case-Control Studies ; Cell Adhesion Molecules/blood ; Child ; Child, Preschool ; Colitis, Ulcerative/blood ; Colitis, Ulcerative/pathology ; Colon/pathology ; Crohn Disease/blood ; Crohn Disease/pathology ; Female ; Gene Expression Regulation ; Humans ; Intestinal Mucosa/pathology ; Male ; Prospective Studies ; Protein Isoforms/blood ; Protein Isoforms/genetics
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Review article: the genetics of the human leucocyte antigen region in inflammatory bowel disease.
    Autorzy:
    Ashton JJ; Human Genetics and Genomic Medicine, Faculty of Medicine, University of Southampton, Southampton, UK.; Department of Paediatric Gastroenterology, Southampton Children's Hospital, Southampton, UK.
    Latham K; Anthony Nolan Research Institute, University College London, London, UK.
    Beattie RM; Department of Paediatric Gastroenterology, Southampton Children's Hospital, Southampton, UK.
    Ennis S; Human Genetics and Genomic Medicine, Faculty of Medicine, University of Southampton, Southampton, UK.
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    Źródło:
    Alimentary pharmacology & therapeutics [Aliment Pharmacol Ther] 2019 Oct; Vol. 50 (8), pp. 885-900. Date of Electronic Publication: 2019 Sep 13.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't; Review
    MeSH Terms:
    Genetic Predisposition to Disease/*genetics
    Genome-Wide Association Study/*methods
    HLA Antigens/*genetics
    Inflammatory Bowel Diseases/*genetics
    HLA Antigens/immunology ; Histocompatibility Antigens Class I/genetics ; Histocompatibility Antigens Class I/immunology ; Histocompatibility Antigens Class II/genetics ; Histocompatibility Antigens Class II/immunology ; Humans ; Inflammatory Bowel Diseases/diagnosis ; Inflammatory Bowel Diseases/immunology ; Tumor Necrosis Factor-alpha/genetics ; Tumor Necrosis Factor-alpha/immunology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Letter: anti-TNF therapy and intestinal resections in Crohn's disease-are we just delaying the inevitable?
    Autorzy:
    Ashton JJ; Department of Paediatric Gastroenterology, Southampton Children's Hospital, Southampton, UK.; Department of Human Genetics and Genomics, University of Southampton, Southampton, UK.
    Beattie RM; Department of Paediatric Gastroenterology, Southampton Children's Hospital, Southampton, UK.
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    Źródło:
    Alimentary pharmacology & therapeutics [Aliment Pharmacol Ther] 2019 Oct; Vol. 50 (7), pp. 842-843.
    Typ publikacji:
    Letter; Research Support, Non-U.S. Gov't; Comment
    MeSH Terms:
    Crohn Disease*
    Digestive System Surgical Procedures*
    Cohort Studies ; Humans ; Infliximab ; Tumor Necrosis Factor-alpha
    Raport
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    GenePy - a score for estimating gene pathogenicity in individuals using next-generation sequencing data.
    Autorzy:
    Mossotto E; Department of Human Genetics and Genomic Medicine, University of Southampton, Southampton, UK. .; Institute for Life Sciences, University of Southampton, Southampton, UK. .
    Ashton JJ; Department of Human Genetics and Genomic Medicine, University of Southampton, Southampton, UK.; Department of Paediatric Gastroenterology, Southampton Children's Hospital, Southampton, UK.
    O'Gorman L; Department of Human Genetics and Genomic Medicine, University of Southampton, Southampton, UK.
    Pengelly RJ; Department of Human Genetics and Genomic Medicine, University of Southampton, Southampton, UK.; Institute for Life Sciences, University of Southampton, Southampton, UK.
    Beattie RM; Department of Paediatric Gastroenterology, Southampton Children's Hospital, Southampton, UK.
    MacArthur BD; Institute for Life Sciences, University of Southampton, Southampton, UK.
    Ennis S; Department of Human Genetics and Genomic Medicine, University of Southampton, Southampton, UK.
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    Źródło:
    BMC bioinformatics [BMC Bioinformatics] 2019 May 16; Vol. 20 (1), pp. 254. Date of Electronic Publication: 2019 May 16.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Software*
    High-Throughput Nucleotide Sequencing/*methods
    Virulence/*genetics
    Alleles ; Cohort Studies ; Databases, Genetic ; Exome ; Gene Frequency/genetics ; Humans ; Phenotype ; Polymorphism, Single Nucleotide/genetics ; Exome Sequencing ; Zygote/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Increased prevalence of anti-TNF therapy in paediatric inflammatory bowel disease is associated with a decline in surgical resections during childhood.
    Autorzy:
    Ashton JJ; Department of Paediatric Gastroenterology, Southampton Children's Hospital, Southampton, UK.; Department of Human Genetics and Genomic Medicine, University of Southampton, Southampton, UK.
    Borca F; NIHR Southampton Biomedical Research Centre, University Hospital Southampton, Southampton, UK.
    Mossotto E; Department of Human Genetics and Genomic Medicine, University of Southampton, Southampton, UK.; NIHR Southampton Biomedical Research Centre, University Hospital Southampton, Southampton, UK.
    Coelho T; Department of Paediatric Gastroenterology, Southampton Children's Hospital, Southampton, UK.
    Batra A; Department of Paediatric Gastroenterology, Southampton Children's Hospital, Southampton, UK.
    Afzal NA; Department of Paediatric Gastroenterology, Southampton Children's Hospital, Southampton, UK.
    Phan HTT; NIHR Southampton Biomedical Research Centre, University Hospital Southampton, Southampton, UK.
    Stanton M; Department of Paediatric Surgery, Southampton Children's Hospital, Southampton, UK.
    Ennis S; Department of Human Genetics and Genomic Medicine, University of Southampton, Southampton, UK.
    Beattie RM; Department of Paediatric Gastroenterology, Southampton Children's Hospital, Southampton, UK.; NIHR Southampton Biomedical Research Centre, University Hospital Southampton, Southampton, UK.
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    Źródło:
    Alimentary pharmacology & therapeutics [Aliment Pharmacol Ther] 2019 Feb; Vol. 49 (4), pp. 398-407. Date of Electronic Publication: 2019 Jan 09.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Colitis, Ulcerative/*drug therapy
    Crohn Disease/*drug therapy
    Tumor Necrosis Factor-alpha/*antagonists & inhibitors
    Adolescent ; Child ; Child, Preschool ; Cohort Studies ; Colitis, Ulcerative/surgery ; Crohn Disease/surgery ; Female ; Humans ; Infant ; Male ; Prevalence
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Genes implicated in thiopurine-induced toxicity: Comparing TPMT enzyme activity with clinical phenotype and exome data in a paediatric IBD cohort.
    Autorzy:
    Coelho T; Human Genetics and Genomic medicine, University of Southampton, Southampton, UK.; Department of Paediatric Gastroenterology, University Hospital Southampton, Southampton, UK.
    Andreoletti G; Human Genetics and Genomic medicine, University of Southampton, Southampton, UK.
    Ashton JJ; Department of Paediatric Gastroenterology, University Hospital Southampton, Southampton, UK.
    Batra A; Department of Paediatric Gastroenterology, University Hospital Southampton, Southampton, UK.
    Afzal NA; Department of Paediatric Gastroenterology, University Hospital Southampton, Southampton, UK.
    Gao Y; Cancer Sciences Division, Faculty of Medicine, University Hospital Southampton, Southampton, UK.
    Williams AP; Cancer Sciences Division, Faculty of Medicine, University Hospital Southampton, Southampton, UK.
    Beattie RM; Department of Paediatric Gastroenterology, University Hospital Southampton, Southampton, UK.
    Ennis S; Human Genetics and Genomic medicine, University of Southampton, Southampton, UK.
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    Źródło:
    Scientific reports [Sci Rep] 2016 Oct 05; Vol. 6, pp. 34658. Date of Electronic Publication: 2016 Oct 05.
    Typ publikacji:
    Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Colitis, Ulcerative*/drug therapy
    Colitis, Ulcerative*/enzymology
    Crohn Disease*/drug therapy
    Crohn Disease*/enzymology
    Crohn Disease*/genetics
    Exome*
    Methyltransferases*/genetics
    Methyltransferases*/metabolism
    Mutation*
    Sulfurtransferases*/genetics
    Sulfurtransferases*/metabolism
    Azathioprine/*adverse effects
    Mercaptopurine/*adverse effects
    Adolescent ; Azathioprine/administration & dosage ; Child ; Child, Preschool ; Female ; Genome-Wide Association Study ; High-Throughput Nucleotide Sequencing ; Humans ; Infant ; Male ; Mercaptopurine/administration & dosage
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
      Wyświetlanie 1-11 z 11

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