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Tytuł :
l-asparaginase production and enhancement by Sarocladium strictum: In vitro evaluation of anti-cancerous properties.
Autorzy :
Golbabaie A; Department of Microbial Biotechnology, School of Biology, College of Science, University of Tehran, Tehran, Iran.
Nouri H; Department of Microbial Biotechnology, School of Biology, College of Science, University of Tehran, Tehran, Iran.
Moghimi H; Department of Microbial Biotechnology, School of Biology, College of Science, University of Tehran, Tehran, Iran.
Khaleghian A; Department of Biochemistry, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran.
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Źródło :
Journal of applied microbiology [J Appl Microbiol] 2020 Aug; Vol. 129 (2), pp. 356-366. Date of Electronic Publication: 2020 Mar 22.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Asparaginase/*pharmacology
Hypocreales/*metabolism
Antineoplastic Agents/isolation & purification ; Apoptosis/drug effects ; Asparaginase/isolation & purification ; Cell Proliferation/drug effects ; HL-60 Cells ; Humans ; Hypocreales/enzymology ; K562 Cells ; Kinetics ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/pathology
Czasopismo naukowe
Tytuł :
Microbial L-asparaginase: purification, characterization and applications.
Autorzy :
Muneer F; Department of Bioinformatics and Biotechnology, Government College University, Faisalabad, Pakistan.
Siddique MH; Department of Bioinformatics and Biotechnology, Government College University, Faisalabad, Pakistan.
Azeem F; Department of Bioinformatics and Biotechnology, Government College University, Faisalabad, Pakistan.
Rasul I; Department of Bioinformatics and Biotechnology, Government College University, Faisalabad, Pakistan.
Muzammil S; Department of Microbiology, Government College University, Faisalabad, Pakistan.
Zubair M; Department of Bioinformatics and Biotechnology, Government College University, Faisalabad, Pakistan.
Afzal M; Department of Bioinformatics and Biotechnology, Government College University, Faisalabad, Pakistan.
Nadeem H; Department of Bioinformatics and Biotechnology, Government College University, Faisalabad, Pakistan. .
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Źródło :
Archives of microbiology [Arch Microbiol] 2020 Jul; Vol. 202 (5), pp. 967-981. Date of Electronic Publication: 2020 Feb 12.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Asparaginase/*chemistry
Bacteria/*enzymology
Fungi/*enzymology
Hodgkin Disease/*drug therapy
Precursor Cell Lymphoblastic Leukemia-Lymphoma/*drug therapy
Ammonia/metabolism ; Asparaginase/genetics ; Asparaginase/isolation & purification ; Asparagine/chemistry ; Aspartic Acid/metabolism ; Humans ; Phylogeny ; Plants
Czasopismo naukowe
Tytuł :
Characterization of a novel type I l-asparaginase from Acinetobacter soli and its ability to inhibit acrylamide formation in potato chips.
Autorzy :
Jiao L; College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, PR China.
Chi H; College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, PR China.
Lu Z; College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, PR China.
Zhang C; College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, PR China.
Chia SR; Department of Chemical and Environmental Engineering, Faculty of Science and Engineering, University of Nottingham Malaysia, 43500 Semenyih, Selangor Darul Ehsan, Malaysia.
Show PL; Department of Chemical and Environmental Engineering, Faculty of Science and Engineering, University of Nottingham Malaysia, 43500 Semenyih, Selangor Darul Ehsan, Malaysia.
Tao Y; College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, PR China.
Lu F; College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, PR China. Electronic address: .
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Źródło :
Journal of bioscience and bioengineering [J Biosci Bioeng] 2020 Jun; Vol. 129 (6), pp. 672-678. Date of Electronic Publication: 2020 Feb 20.
Typ publikacji :
Journal Article
MeSH Terms :
Acinetobacter/*enzymology
Acrylamide/*metabolism
Asparaginase/*metabolism
Solanum tuberosum/*metabolism
Acinetobacter/genetics ; Asparaginase/genetics ; Asparagine/metabolism ; Enzyme Stability ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Glutamine/metabolism ; Snacks
SCR Organism :
Acinetobacter soli
Czasopismo naukowe
Tytuł :
Heterologous gene expression and characterization of TK2246, a highly active and thermostable plant type l-asparaginase from Thermococcus kodakarensis.
Autorzy :
Chohan SM; School of Biological Sciences, University of the Punjab, Quaid-e-Azam Campus, Lahore 54590, Pakistan.
Sajed M; School of Biological Sciences, University of the Punjab, Quaid-e-Azam Campus, Lahore 54590, Pakistan.
Naeem SU; Institute of Biochemistry and Biotechnology, University of the Punjab, Quaid-e-Azam Campus, Lahore 54590, Pakistan.
Rashid N; School of Biological Sciences, University of the Punjab, Quaid-e-Azam Campus, Lahore 54590, Pakistan. Electronic address: .
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2020 Mar 15; Vol. 147, pp. 131-137. Date of Electronic Publication: 2020 Jan 07.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression*
Temperature*
Archaeal Proteins/*genetics
Asparaginase/*genetics
Thermococcus/*enzymology
Amino Acid Sequence ; Archaeal Proteins/metabolism ; Asparaginase/chemistry ; Asparaginase/metabolism ; Cloning, Molecular ; Edetic Acid/pharmacology ; Enzyme Stability/drug effects ; Hydrogen-Ion Concentration ; Ions ; Kinetics ; Metals/pharmacology ; Recombinant Proteins/isolation & purification ; Sequence Analysis, Protein ; Structural Homology, Protein ; Substrate Specificity/drug effects
Czasopismo naukowe
Tytuł :
Determination of glycation levels in Erwinia chrysanthemi asparaginase drug product by liquid chromatography - mass spectrometry.
Autorzy :
Kanda P; Porton Biopharma Ltd., Manor Farm Road, Porton Down, Salisbury SP4 0JG, United Kingdom. Electronic address: .
Minshull TC; Porton Biopharma Ltd., Manor Farm Road, Porton Down, Salisbury SP4 0JG, United Kingdom.
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Źródło :
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences [Eur J Pharm Sci] 2020 Mar 30; Vol. 145, pp. 105253. Date of Electronic Publication: 2020 Feb 04.
Typ publikacji :
Journal Article
MeSH Terms :
Asparaginase/*metabolism
Chemistry, Pharmaceutical/*methods
Pectobacterium chrysanthemi/*metabolism
Asparaginase/analysis ; Chromatography, Liquid/methods ; Glycosylation ; Humans ; Isoelectric Focusing/methods ; Mass Spectrometry/methods ; Pectobacterium chrysanthemi/chemistry
Czasopismo naukowe
Tytuł :
Adolescent Male With Epigastric Pain.
Autorzy :
Cao C; Department of Pediatrics, Los Angeles County + University of Southern California Medical Center, Keck School of Medicine, Los Angeles, CA.
Chan RY; Department of Pediatrics, Los Angeles County + University of Southern California Medical Center, Keck School of Medicine, Los Angeles, CA.
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Źródło :
Annals of emergency medicine [Ann Emerg Med] 2020 Apr; Vol. 75 (4), pp. 546-557.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Asparaginase/*adverse effects
Hypertriglyceridemia/*chemically induced
Triglycerides/*blood
Adolescent ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Asparaginase/administration & dosage ; Chest Pain/etiology ; Humans ; Male ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/complications ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/drug therapy
Czasopismo naukowe
Tytuł :
Study of L-Asparaginase, Vincristine, and Dexamethasone Combined With Intensity-modulated Radiation Therapy in Early-Stage Nasal NK/T-Cell Lymphoma.
Autorzy :
Hu Y; Department of Lymphoma, Affiliated Hospital of Guizhou Medical University, Guizhou Province Tumor Hospital, Guiyang, Guizhou Province.
Chen M; Department of Lymphoma, Affiliated Hospital of Guizhou Medical University, Guizhou Province Tumor Hospital, Guiyang, Guizhou Province.
Song Y; Department of Oncology, Third Affiliated Hospital of Army Medical University, Chongqing.
Liu X; Department of Thoracic Oncology, Third People's Hospital of Jiujiang City, Jiujiang, China.
Gou F; Department of Lymphoma, Affiliated Hospital of Guizhou Medical University, Guizhou Province Tumor Hospital, Guiyang, Guizhou Province.
Zhang J; Department of Lymphoma, Affiliated Hospital of Guizhou Medical University, Guizhou Province Tumor Hospital, Guiyang, Guizhou Province.
Huang Y; Department of Lymphoma, Affiliated Hospital of Guizhou Medical University, Guizhou Province Tumor Hospital, Guiyang, Guizhou Province.
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Źródło :
American journal of clinical oncology [Am J Clin Oncol] 2020 Apr; Vol. 43 (4), pp. 257-262.
Typ publikacji :
Journal Article
MeSH Terms :
Killer Cells, Natural*
Radiotherapy, Intensity-Modulated*/adverse effects
Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
Asparaginase/*administration & dosage
Dexamethasone/*administration & dosage
Lymphoma, T-Cell/*drug therapy
Lymphoma, T-Cell/*radiotherapy
Nose Neoplasms/*drug therapy
Nose Neoplasms/*radiotherapy
Vincristine/*administration & dosage
Adolescent ; Adult ; Aged ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Asparaginase/adverse effects ; Combined Modality Therapy ; Female ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Treatment Outcome ; Vincristine/adverse effects ; Young Adult
Czasopismo naukowe
Tytuł :
How I treat the toxicities of pegasparaginase in adults with acute lymphoblastic leukemia.
Autorzy :
Aldoss I; Gehr Family Center for Leukemia Research, Department of Hematology and Hematopoietic Cell Transplantation, City of Hope Medical Center, Duarte, CA; and.
Douer D; Jane Anne Nohl Division of Hematology, University of Southern California, Los Angeles, CA.
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Źródło :
Blood [Blood] 2020 Mar 26; Vol. 135 (13), pp. 987-995.
Typ publikacji :
Case Reports; Journal Article; Review
MeSH Terms :
Antineoplastic Agents/*adverse effects
Asparaginase/*adverse effects
Drug-Related Side Effects and Adverse Reactions/*etiology
Polyethylene Glycols/*adverse effects
Precursor Cell Lymphoblastic Leukemia-Lymphoma/*complications
Antineoplastic Agents/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Asparaginase/therapeutic use ; Drug-Related Side Effects and Adverse Reactions/diagnosis ; Drug-Related Side Effects and Adverse Reactions/therapy ; Humans ; Polyethylene Glycols/therapeutic use ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy
Czasopismo naukowe
Tytuł :
A single-center multidisciplinary approach to managing the global Erwinia asparaginase shortage.
Autorzy :
Marini BL; Department of Pharmacy Services and Clinical Sciences Michigan Medicine, University of Michigan College of Pharmacy, Ann Arbor, MI, USA.
Brown J; Department of Pharmacy Services and Clinical Sciences Michigan Medicine, University of Michigan College of Pharmacy, Ann Arbor, MI, USA.
Benitez L; Department of Pharmacy Services and Clinical Sciences Michigan Medicine, University of Michigan College of Pharmacy, Ann Arbor, MI, USA.
Walling E; Department of Pediatrics and Communicable Diseases Division of Pediatric Hematology and Oncology, University of Michigan Medical School, Ann Arbor, MI, USA.
Hutchinson RJ; Department of Pediatrics and Communicable Diseases Division of Pediatric Hematology and Oncology, University of Michigan Medical School, Ann Arbor, MI, USA.
Mody R; Department of Pediatrics and Communicable Diseases Division of Pediatric Hematology and Oncology, University of Michigan Medical School, Ann Arbor, MI, USA.
Jasty Rao R; Department of Pediatrics and Communicable Diseases Division of Pediatric Hematology and Oncology, University of Michigan Medical School, Ann Arbor, MI, USA.
Slagle L; Department of Pediatrics and Communicable Diseases Division of Pediatric Hematology and Oncology, University of Michigan Medical School, Ann Arbor, MI, USA.
Bishop L; Department of Pediatrics and Communicable Diseases Division of Pediatric Hematology and Oncology, University of Michigan Medical School, Ann Arbor, MI, USA.
Pettit K; Department of Internal Medicine Division of Hematology and Oncology, University of Michigan Medical School, Ann Arbor, MI, USA.
Bixby DL; Department of Internal Medicine Division of Hematology and Oncology, University of Michigan Medical School, Ann Arbor, MI, USA.
Burke PW; Department of Internal Medicine Division of Hematology and Oncology, University of Michigan Medical School, Ann Arbor, MI, USA.
Perissinotti AJ; Department of Pharmacy Services and Clinical Sciences Michigan Medicine, University of Michigan College of Pharmacy, Ann Arbor, MI, USA.
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Źródło :
Leukemia & lymphoma [Leuk Lymphoma] 2019 Dec; Vol. 60 (12), pp. 2854-2868. Date of Electronic Publication: 2019 May 17.
Typ publikacji :
Journal Article
MeSH Terms :
Disease Management*
Institutional Management Teams*
Interdisciplinary Communication*
Patient Care Team*
Antineoplastic Agents/*supply & distribution
Asparaginase/*supply & distribution
Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/adverse effects ; Antineoplastic Agents/economics ; Asparaginase/administration & dosage ; Asparaginase/adverse effects ; Asparaginase/economics ; Clinical Decision-Making ; Drug Hypersensitivity/diagnosis ; Drug Hypersensitivity/immunology ; Drug Monitoring ; Drug Substitution ; Global Health ; Guidelines as Topic ; Humans
Czasopismo naukowe
Tytuł :
Optimizing pegylated asparaginase use: An institutional guideline for dosing, monitoring, and management.
Autorzy :
Bade NA; Division of Hematology/Oncology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.; Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, MD, USA.
Lu C; Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, MD, USA.
Patzke CL; Department of Pharmacy Practice and Administration, Ernest Mario School of Pharmacy at Rutgers, The State University of New Jersey, Piscataway, NJ, USA.; Department of Pharmacy, Hackensack University Medical Center, Hackensack, NJ, USA.
Baer MR; Division of Hematology/Oncology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.; Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, MD, USA.
Duong VH; Division of Hematology/Oncology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.; Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, MD, USA.
Law JY; Division of Hematology/Oncology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.; Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, MD, USA.
Lee ST; Division of Hematology/Oncology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.; Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, MD, USA.
Sausville EA; Division of Hematology/Oncology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.; Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, MD, USA.
Zimrin AB; Division of Hematology/Oncology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.; Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, MD, USA.
Duffy AP; Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, MD, USA.; Department of Pharmacy Practice, University of Maryland School of Pharmacy, Baltimore, MD, USA.
Lawson J; Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, MD, USA.
Emadi A; Division of Hematology/Oncology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.; Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, MD, USA.
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Źródło :
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners [J Oncol Pharm Pract] 2020 Jan; Vol. 26 (1), pp. 74-92. Date of Electronic Publication: 2019 Mar 27.
Typ publikacji :
Journal Article
MeSH Terms :
Disease Management*
Antineoplastic Agents/*administration & dosage
Asparaginase/*administration & dosage
Cancer Care Facilities/*standards
Drug Monitoring/*standards
Polyethylene Glycols/*administration & dosage
Practice Guidelines as Topic/*standards
Adult ; Antineoplastic Agents/adverse effects ; Asparaginase/adverse effects ; Child, Preschool ; Dose-Response Relationship, Drug ; Drug Monitoring/methods ; Humans ; Polyethylene Glycols/adverse effects ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/epidemiology ; Thrombosis/chemically induced ; Thrombosis/epidemiology ; Thrombosis/prevention & control ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Production, purification and kinetic characterization of glutaminase free anti-leukemic L-asparaginase with low endotoxin level from novel soil isolate.
Autorzy :
Prakash P; Department of Bio-Engineering, Birla Institute of Technology, Mesra, Ranchi.
Singh HR; Department of Bio-Engineering, Birla Institute of Technology, Mesra, Ranchi.
Jha SK; Department of Bio-Engineering, Birla Institute of Technology, Mesra, Ranchi.
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Źródło :
Preparative biochemistry & biotechnology [Prep Biochem Biotechnol] 2020; Vol. 50 (3), pp. 260-271. Date of Electronic Publication: 2019 Nov 23.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents*/chemistry
Antineoplastic Agents*/isolation & purification
Asparaginase*/chemistry
Asparaginase*/isolation & purification
Soil Microbiology*
Bacillus/*enzymology
Endotoxins/*analysis
SCR Organism :
Bacillus altitudinis
Czasopismo naukowe
Tytuł :
Improvement of the activity of l-asparaginase I improvement of the catalytic activity of l-asparaginase I from Bacillus megaterium H-1 by in vitro directed evolution.
Autorzy :
Lu X; College of Food Science and Technology, Nanjing Agriculture University, Xuanwu District, Weigang No. 1, Nanjing 210095, China.
Chen J; College of Food Science and Technology, Nanjing Agriculture University, Xuanwu District, Weigang No. 1, Nanjing 210095, China.
Jiao L; College of Food Science and Technology, Nanjing Agriculture University, Xuanwu District, Weigang No. 1, Nanjing 210095, China.
Zhong L; College of Food Science and Technology, Nanjing Agriculture University, Xuanwu District, Weigang No. 1, Nanjing 210095, China.
Lu Z; College of Food Science and Technology, Nanjing Agriculture University, Xuanwu District, Weigang No. 1, Nanjing 210095, China.
Zhang C; College of Food Science and Technology, Nanjing Agriculture University, Xuanwu District, Weigang No. 1, Nanjing 210095, China.
Lu F; College of Food Science and Technology, Nanjing Agriculture University, Xuanwu District, Weigang No. 1, Nanjing 210095, China. Electronic address: .
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Źródło :
Journal of bioscience and bioengineering [J Biosci Bioeng] 2019 Dec; Vol. 128 (6), pp. 683-689. Date of Electronic Publication: 2019 Jul 18.
Typ publikacji :
Journal Article
MeSH Terms :
Asparaginase/*metabolism
Bacillus megaterium/*enzymology
Asparaginase/chemistry ; Asparaginase/genetics ; Bacillus megaterium/genetics ; Biocatalysis ; Catalytic Domain ; Hydrogen Bonding ; Models, Molecular ; Protein Structure, Tertiary ; Structural Homology, Protein
Czasopismo naukowe
Tytuł :
Application of a protein domain as chaperone for enhancing biological activity and stability of other proteins.
Autorzy :
Jena R; Kusuma School of Biological Sciences, Indian Institute of Technology Delhi, New Delhi, India.
Garg DK; School of Biotechnology, Jawaharlal Nehru University, New Delhi, India.
Achary MMV; International Center of Genetic Engineering and Biotechnology, New Delhi, India.
Singh J; Kusuma School of Biological Sciences, Indian Institute of Technology Delhi, New Delhi, India.
Tomar R; Kusuma School of Biological Sciences, Indian Institute of Technology Delhi, New Delhi, India.
Choudhury L; School of Biotechnology, Guru Gobind Singh Indraprastha University, New Delhi, India.
Bansal R; Department of Chemical Engineering Indian Institute of Technology Delhi, New Delhi, India.
Kundu B; Kusuma School of Biological Sciences, Indian Institute of Technology Delhi, New Delhi, India. Electronic address: .
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Źródło :
Journal of biotechnology [J Biotechnol] 2020 Feb 20; Vol. 310, pp. 68-79. Date of Electronic Publication: 2020 Jan 31.
Typ publikacji :
Journal Article
MeSH Terms :
Archaeal Proteins/*chemistry
Asparaginase/*chemistry
Molecular Chaperones/*chemistry
Pyrococcus furiosus/*chemistry
Archaeal Proteins/genetics ; Asparaginase/genetics ; Molecular Chaperones/genetics ; Plasmodium falciparum/chemistry ; Plasmodium falciparum/genetics ; Protein Domains ; Protein Stability ; Pyrococcus furiosus/genetics ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Thermococcus/chemistry ; Thermococcus/genetics
Czasopismo naukowe
Tytuł :
Clinical decisions following implementation of asparaginase activity monitoring in pediatric patients with acute lymphoblastic leukemia: Experience from a single-center study.
Autorzy :
Nadeem K; Department of Pharmacy, The Hospital for Sick Children, Toronto, Canada.; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Canada.
Colantonio D; Pathology and Laboratory Medicine, University of Ottawa, Ottawa, Canada.; The Ottawa Hospital/Eastern Ontario Regional Laboratory Association, Ottawa, Canada.
Kircanski I; Department of Pharmacy, The Hospital for Sick Children, Toronto, Canada.; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Canada.
Naqvi A; Division of Haematology/Oncology, Department of Paediatrics, The Hospital for Sick Children, Toronto, Canada.
Hitzler J; Division of Haematology/Oncology, Department of Paediatrics, The Hospital for Sick Children, Toronto, Canada.; Developmental and Stem Cell Biology, Research Institute, The Hospital for Sick Children, Toronto, Canada.
Whitlock JA; Division of Haematology/Oncology, Department of Paediatrics, The Hospital for Sick Children, Toronto, Canada.; Faculty of Medicine, University of Toronto, Toronto, Canada.; Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, Toronto, Canada.
Dupuis LL; Department of Pharmacy, The Hospital for Sick Children, Toronto, Canada.; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Canada.; Division of Haematology/Oncology, Department of Paediatrics, The Hospital for Sick Children, Toronto, Canada.; Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, Toronto, Canada.
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Źródło :
Pediatric blood & cancer [Pediatr Blood Cancer] 2020 Feb; Vol. 67 (2), pp. e28044. Date of Electronic Publication: 2019 Oct 18.
Typ publikacji :
Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Clinical Decision-Making*
Antineoplastic Agents/*therapeutic use
Asparaginase/*metabolism
Biomarkers, Tumor/*analysis
Polyethylene Glycols/*therapeutic use
Precursor Cell Lymphoblastic Leukemia-Lymphoma/*enzymology
Asparaginase/therapeutic use ; Canada/epidemiology ; Child ; Child, Preschool ; Drug Hypersensitivity/drug therapy ; Drug Hypersensitivity/epidemiology ; Female ; Follow-Up Studies ; Humans ; Incidence ; Male ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/pathology ; Prognosis ; Retrospective Studies
Czasopismo naukowe
Tytuł :
Disordered hemostasis associated with severely depressed fibrinolysis demonstrated using a simultaneous thrombin and plasmin generation assay during L-asparaginase induction therapy in pediatric acute lymphoblastic leukemia.
Autorzy :
Ishihara T; Department of Pediatrics, Nara Medical University, Kashihara, Japan.
Nogami K; Department of Pediatrics, Nara Medical University, Kashihara, Japan.
Ochi S; Department of Pediatrics, Nara Medical University, Kashihara, Japan.
Ishida T; Department of Hematology and Oncology, Children's Cancer Center, Kobe Children's Hospital, Kobe, Japan.
Kosaka Y; Department of Hematology and Oncology, Children's Cancer Center, Kobe Children's Hospital, Kobe, Japan.
Sawada A; Department of Hematology/Oncology, Osaka Women's and Children's Hospital, Osaka, Japan.
Inoue M; Department of Hematology/Oncology, Osaka Women's and Children's Hospital, Osaka, Japan.
Osone S; Department of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Imamura T; Department of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Hosoi H; Department of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Shima M; Department of Pediatrics, Nara Medical University, Kashihara, Japan.
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Źródło :
Pediatric blood & cancer [Pediatr Blood Cancer] 2020 Jan; Vol. 67 (1), pp. e28016. Date of Electronic Publication: 2019 Sep 25.
Typ publikacji :
Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Asparaginase/*adverse effects
Blood Coagulation Disorders/*pathology
Fibrinolysin/*metabolism
Fibrinolysis/*drug effects
Hemostasis/*drug effects
Precursor Cell Lymphoblastic Leukemia-Lymphoma/*drug therapy
Thrombin/*metabolism
Adolescent ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/adverse effects ; Asparaginase/administration & dosage ; Blood Coagulation Disorders/chemically induced ; Blood Coagulation Disorders/metabolism ; Child ; Child, Preschool ; Female ; Follow-Up Studies ; Humans ; Induction Chemotherapy ; Infant ; Japan ; Male ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/pathology ; Prognosis ; Prospective Studies
Czasopismo naukowe
Tytuł :
Erythrocyte-encapsulated asparaginase (eryaspase) combined with chemotherapy in second-line treatment of advanced pancreatic cancer: An open-label, randomized Phase IIb trial.
Autorzy :
Hammel P; Digestive and Medical Oncology Unit, Hôpital Beaujon, Assistance Publique - Hôpitaux de Paris, University Denis Diderot Paris VII, 92110 Clichy, France. Electronic address: .
Fabienne P; Parc Euromedecine, 208 Rue Des Apothicaires, 34070 Montpellier, France.
Mineur L; Institut Sainte Catherine, Gastrointestinal and Liver Cancer Unit, Chemin de Baigne Pieds, 84000 Avignon, France.
Metges JP; CHRU de Brest - Hôpital Morvan, 2 Avenue Foch, 29609 Brest, France.
Andre T; Hôpital Saint-Antoine, 184 Rue du Faubourg Saint-Antoine, 75012 Paris, and Sorbonne Universités, France.
De La Fouchardiere C; Medical Oncology Department, Centre Leon Berard, Lyon, France.
Louvet C; Department of Medical Oncology, Institut Mutualiste Montsouris, 42 Boulevard Jourdan, 75014 Paris, France.
El Hajbi F; Centre Oscar Lambret, 3 Rue Frédéric Combemale, 59000 Lille, France.
Faroux R; Les Oudairies, Hospital La Roche-Sur-Yon, Boulevard Stephane Moreau, 85000 La Roche Sur Yon, France.
Guimbaud R; Institut Universitaire du Cancer, Avenue Hubert Curien, 31100 Toulouse, France.
Tougeron D; Gastroenterology Department and Medical Oncology Department, Poitiers University Hospital, Faculty of Medicine of Poitiers, 86000 Poitiers, France.
Bouche O; Service Oncologie Digestive, CHU Reims, Avenue Général Koenig, 51092 Reims Cede, France.
Lecomte T; Department of Hepatogastroenterology and Digestive Oncology, CHU de Tours, 37044 Tours Cedex, France.
Rebischung C; Groupe Hospitalier Mutualiste de Grenoble, 8 Rue Docteur Calmette, 38100 Grenoble, France.
Tournigand C; Service d'Oncologie médicale, Hôpital Henri Mondor, AP-HP, Université Paris-Est, 94010 Créteil, France.
Cros J; Beaujon University Hospital, Department of Pathology-INSERM U1149, 100 Bvd Gal Lerclerc, 92110 Clichy, France.
Kay R; RK Statistics Ltd, St Giles View, Main Street, Great Longstone, Bakewell, DE45 1TZ, UK.
Hamm A; Cytel Inc., 675 Massachusetts Ave Cambridge, MA 02139, USA.
Gupta A; ERYTECH, One Main Street, Suite 1150, Cambridge, MA 02142, USA.
Bachet JB; Sorbonne Universités, UPMC Université, Gastroenterology and Digestive Oncology Department, Pitié Salpêtrière Hospital, 75013 Paris, France.
El Hariry I; ERYTECH, One Main Street, Suite 1150, Cambridge, MA 02142, USA.
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Źródło :
European journal of cancer (Oxford, England : 1990) [Eur J Cancer] 2020 Jan; Vol. 124, pp. 91-101. Date of Electronic Publication: 2019 Nov 21.
Typ publikacji :
Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Adenocarcinoma/*drug therapy
Antineoplastic Combined Chemotherapy Protocols/*administration & dosage
Asparaginase/*administration & dosage
Neutropenia/*epidemiology
Pancreatic Neoplasms/*drug therapy
Adenocarcinoma/mortality ; Adenocarcinoma/pathology ; Adult ; Aged ; Aged, 80 and over ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Asparaginase/adverse effects ; Biopsy ; Carbon-Nitrogen Ligases with Glutamine as Amide-N-Donor/metabolism ; Deoxycytidine/administration & dosage ; Deoxycytidine/adverse effects ; Deoxycytidine/analogs & derivatives ; Female ; Fluorouracil/administration & dosage ; Fluorouracil/adverse effects ; Follow-Up Studies ; Humans ; Kaplan-Meier Estimate ; Leucovorin/administration & dosage ; Leucovorin/adverse effects ; Male ; Middle Aged ; Neoplasm Staging ; Neutropenia/chemically induced ; Organoplatinum Compounds/administration & dosage ; Organoplatinum Compounds/adverse effects ; Pancreas/pathology ; Pancreatic Neoplasms/mortality ; Pancreatic Neoplasms/pathology ; Progression-Free Survival ; Response Evaluation Criteria in Solid Tumors
SCR Protocol :
Folfox protocol
Czasopismo naukowe
Tytuł :
Maltose functionalized magnetic core/shell Fe 3 O 4 @Au nanoparticles for an efficient l-asparaginase immobilization.
Autorzy :
Tarhan T; Mardin Artuklu University, Vocational High School of Health Services, 47100 Mardin, Turkey; Department of Genetics and Bioengineering, Yeditepe University, Atasehir, Istanbul 34755, Turkey.
Ulu A; Department of Chemistry, Faculty of Science & Arts, Inonu University, Malatya 44280, Turkey.
Sariçam M; Department of Genetics and Bioengineering, Yeditepe University, Atasehir, Istanbul 34755, Turkey.
Çulha M; Department of Genetics and Bioengineering, Yeditepe University, Atasehir, Istanbul 34755, Turkey.
Ates B; Department of Chemistry, Faculty of Science & Arts, Inonu University, Malatya 44280, Turkey. Electronic address: .
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2020 Jan 01; Vol. 142, pp. 443-451. Date of Electronic Publication: 2019 Oct 05.
Typ publikacji :
Journal Article
MeSH Terms :
Asparaginase/*chemistry
Enzymes, Immobilized/*chemistry
Ferric Compounds/*chemistry
Gold/*chemistry
Magnets/*chemistry
Maltose/*chemistry
Metal Nanoparticles/*chemistry
Asparaginase/metabolism ; Enzyme Stability ; Enzymes, Immobilized/metabolism ; Hydrogen-Ion Concentration ; Kinetics ; Temperature
Czasopismo naukowe
Tytuł :
Expression of a recombinant bacterial L-asparaginase in human cells.
Autorzy :
Dantas RC; Experimental Biology Center (NUBEX), University of Fortaleza (UNIFOR), Fortaleza, Brazil.
Caetano LF; Oswaldo Cruz Foundation (FIOCRUZ), Fortaleza, Brazil.
Torres ALS; Oswaldo Cruz Foundation (FIOCRUZ), Fortaleza, Brazil.
Alves MS; Experimental Biology Center (NUBEX), University of Fortaleza (UNIFOR), Fortaleza, Brazil.
Silva ETMF; Experimental Biology Center (NUBEX), University of Fortaleza (UNIFOR), Fortaleza, Brazil.
Teixeira LPR; Experimental Biology Center (NUBEX), University of Fortaleza (UNIFOR), Fortaleza, Brazil.
Teixeira DC; Experimental Biology Center (NUBEX), University of Fortaleza (UNIFOR), Fortaleza, Brazil.
de Azevedo Moreira R; Experimental Biology Center (NUBEX), University of Fortaleza (UNIFOR), Fortaleza, Brazil.
Fonseca MHG; Oswaldo Cruz Foundation (FIOCRUZ), Fortaleza, Brazil.
Gaudêncio Neto S; Experimental Biology Center (NUBEX), University of Fortaleza (UNIFOR), Fortaleza, Brazil.
Martins LT; Experimental Biology Center (NUBEX), University of Fortaleza (UNIFOR), Fortaleza, Brazil.
Furtado GP; Oswaldo Cruz Foundation (FIOCRUZ), Fortaleza, Brazil.
Tavares KCS; Experimental Biology Center (NUBEX), University of Fortaleza (UNIFOR), Fortaleza, Brazil. .
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Źródło :
BMC research notes [BMC Res Notes] 2019 Dec 05; Vol. 12 (1), pp. 794. Date of Electronic Publication: 2019 Dec 05.
Typ publikacji :
Journal Article
MeSH Terms :
Asparaginase/*genetics
Escherichia coli/*enzymology
Asparaginase/metabolism ; Cloning, Molecular ; Escherichia coli/genetics ; Glycosylation ; HEK293 Cells ; Humans ; Hydrogen-Ion Concentration ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Temperature
Czasopismo naukowe
Tytuł :
The effect of asparaginase therapy on methotrexate toxicity and efficacy in children with acute lymphoblastic leukemia.
Autorzy :
Kloos RQH; Department of Pediatric Oncology and Hematology, Erasmus MC - Sophia Children's Hospital, Rotterdam, The Netherlands.
Pieters R; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
van den Bos C; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Academic Medical Center, Amsterdam, The Netherlands.
van Eijkelenburg NKA; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
de Jonge R; Department of Clinical Chemistry, Amsterdam UMC, Amsterdam, The Netherlands.
van der Sluis IM; Department of Pediatric Oncology and Hematology, Erasmus MC - Sophia Children's Hospital, Rotterdam, The Netherlands.; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
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Źródło :
Leukemia & lymphoma [Leuk Lymphoma] 2019 Dec; Vol. 60 (12), pp. 3002-3010. Date of Electronic Publication: 2019 May 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*therapeutic use
Asparaginase/*therapeutic use
Precursor Cell Lymphoblastic Leukemia-Lymphoma/*drug therapy
Age Factors ; Antineoplastic Agents/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Asparaginase/administration & dosage ; Child ; Child, Preschool ; Drug-Related Side Effects and Adverse Reactions/diagnosis ; Drug-Related Side Effects and Adverse Reactions/etiology ; Female ; Humans ; Male ; Methotrexate/administration & dosage ; Methotrexate/adverse effects ; Methotrexate/therapeutic use ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/diagnosis ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/mortality ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Space for Calaspargase? A New Asparaginase for Acute Lymphoblastic Leukemia.
Autorzy :
Lew G; Aflac Cancer & Blood Disorders Center, Emory University/Children's Healthcare of Atlanta, Atlanta, Geogia. .
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Źródło :
Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2020 Jan 15; Vol. 26 (2), pp. 325-327. Date of Electronic Publication: 2019 Oct 22.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Asparaginase*
Precursor Cell Lymphoblastic Leukemia-Lymphoma*
Antineoplastic Combined Chemotherapy Protocols ; Child ; Humans ; Polyethylene Glycols ; Young Adult
Czasopismo naukowe

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