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Tytuł:
Blood glutamate scavengers increase pro-apoptotic signaling and reduce metastatic melanoma growth in-vivo.
Autorzy:
Goldshmit Y; Steyer School of Health Professions, Sackler Faculty of Medicine, Tel-Aviv University, P.O. Box 39040, 6997801, Tel Aviv, Israel.; Australian Regenerative Medicine Institute, Monash Biotechnology, 15 Innovation Walk, Clayton, VIC, 3800, Australia.
Perelroizen R; Shmunis School of Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, 6997801, Tel Aviv, Israel.; Sagol School of Neuroscience, Tel Aviv University, 6997801, Tel Aviv, Israel.
Yakovchuk A; Steyer School of Health Professions, Sackler Faculty of Medicine, Tel-Aviv University, P.O. Box 39040, 6997801, Tel Aviv, Israel.
Banyas E; Steyer School of Health Professions, Sackler Faculty of Medicine, Tel-Aviv University, P.O. Box 39040, 6997801, Tel Aviv, Israel.
Mayo L; Shmunis School of Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, 6997801, Tel Aviv, Israel.; Sagol School of Neuroscience, Tel Aviv University, 6997801, Tel Aviv, Israel.
David S; Steyer School of Health Professions, Sackler Faculty of Medicine, Tel-Aviv University, P.O. Box 39040, 6997801, Tel Aviv, Israel.
Benbenishty A; Department of Biological Regulation, Weizmann Institute of Science, 7610001, Rehovot, Israel.
Blinder P; Sagol School of Neuroscience, Tel Aviv University, 6997801, Tel Aviv, Israel.; Neurobiology Department, George S. Wise Faculty of Life Sciences, Tel Aviv University, 6997801, Tel Aviv, Israel.
Shalom M; Steyer School of Health Professions, Sackler Faculty of Medicine, Tel-Aviv University, P.O. Box 39040, 6997801, Tel Aviv, Israel.
Ruban A; Steyer School of Health Professions, Sackler Faculty of Medicine, Tel-Aviv University, P.O. Box 39040, 6997801, Tel Aviv, Israel. .; Sagol School of Neuroscience, Tel Aviv University, 6997801, Tel Aviv, Israel. .
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Źródło:
Scientific reports [Sci Rep] 2021 Jul 19; Vol. 11 (1), pp. 14644. Date of Electronic Publication: 2021 Jul 19.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Aspartate Aminotransferase, Cytoplasmic/*administration & dosage
Brain Neoplasms/*drug therapy
Glutamic Acid/*metabolism
Melanoma/*drug therapy
Oxaloacetic Acid/*administration & dosage
Animals ; Apoptosis/drug effects ; Aspartate Aminotransferase, Cytoplasmic/pharmacology ; Brain Neoplasms/pathology ; Brain Neoplasms/secondary ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Drug Therapy, Combination ; Glioblastoma/drug therapy ; Glioblastoma/pathology ; Glioblastoma/secondary ; Humans ; Melanoma/pathology ; Mice ; Mice, Inbred C57BL ; Molecular Targeted Therapy/methods ; Oxaloacetic Acid/pharmacology ; Recombinant Proteins/administration & dosage ; Signal Transduction/drug effects ; Tumor Microenvironment/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Co-administration with A1M does not influence apoptotic response of Lu-octreotate in GOT1 neuroendocrine tumors.
Autorzy:
Rassol N; Department of Medical Radiation Sciences, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. .; Sahlgrenska Center for Cancer Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. .
Andersson C; Department of Medical Radiation Sciences, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Sahlgrenska Center for Cancer Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Pettersson D; Department of Medical Radiation Sciences, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Sahlgrenska Center for Cancer Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Al-Awar A; Department of Medical Radiation Sciences, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Sahlgrenska Center for Cancer Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Shubbar E; Department of Medical Radiation Sciences, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Sahlgrenska Center for Cancer Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Kovács A; Department of Clinical Pathology, Sahlgrenska University Hospital, Gothenburg, Sweden.
Åkerström B; Department of Clinical Sciences, Infection Medicine, Lund University, Lund, Sweden.
Gram M; Neonatology Unit, Department of Clinical Sciences, Pediatrics, Lund University, Lund, Sweden.
Helou K; Sahlgrenska Center for Cancer Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Forssell-Aronsson E; Department of Medical Radiation Sciences, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Sahlgrenska Center for Cancer Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Medical Physics and Biomedical Engineering, Sahlgrenska University Hospital, Gothenburg, Sweden.
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Źródło:
Scientific reports [Sci Rep] 2023 Apr 19; Vol. 13 (1), pp. 6417. Date of Electronic Publication: 2023 Apr 19.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Neuroendocrine Tumors*/drug therapy
Neuroendocrine Tumors*/genetics
Neuroendocrine Tumors*/metabolism
Humans ; Mice ; Animals ; Octreotide/pharmacology ; Octreotide/therapeutic use ; Aspartate Aminotransferase, Cytoplasmic
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A novel circular RNA hsa_circRNA_103809/miR-377-3p/GOT1 pathway regulates cisplatin-resistance in non-small cell lung cancer (NSCLC).
Autorzy:
Zhu X; The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, 310022, Zhejiang, China.
Han J; The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, 310022, Zhejiang, China.
Lan H; The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, 310022, Zhejiang, China.
Lin Q; The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, 310022, Zhejiang, China.
Wang Y; The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, 310022, Zhejiang, China. .
Sun X; The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, 310022, Zhejiang, China. .
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Źródło:
BMC cancer [BMC Cancer] 2020 Dec 04; Vol. 20 (1), pp. 1190. Date of Electronic Publication: 2020 Dec 04.
Typ publikacji:
Journal Article
MeSH Terms:
Aspartate Aminotransferase, Cytoplasmic/*physiology
Carcinoma, Non-Small-Cell Lung/*drug therapy
Cisplatin/*pharmacology
Lung Neoplasms/*drug therapy
MicroRNAs/*physiology
Neoplasm Proteins/*physiology
RNA, Circular/*physiology
RNA, Neoplasm/*physiology
3' Untranslated Regions ; Animals ; Apoptosis ; Aspartate Aminotransferase, Cytoplasmic/genetics ; Cell Division ; Cell Line, Tumor ; Gene Knockdown Techniques ; Genetic Vectors/pharmacology ; Humans ; Mice ; Mice, Nude ; MicroRNAs/genetics ; Neoplasm Proteins/genetics ; RNA, Circular/antagonists & inhibitors ; RNA, Circular/genetics ; RNA, Neoplasm/antagonists & inhibitors ; RNA, Neoplasm/genetics ; RNA, Small Interfering/genetics ; RNA, Small Interfering/pharmacology ; Signal Transduction/genetics ; Signal Transduction/physiology ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Tumor Cell Derived Exosomal GOT1 Suppresses Tumor Cell Ferroptosis to Accelerate Pancreatic Cancer Progression by Activating Nrf2/HO-1 Axis via Upregulating CCR2 Expression.
Autorzy:
Guo Y; Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Chen T; Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Liang X; Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Gou S; Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Xiong J; Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Cui J; Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Peng T; Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
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Źródło:
Cells [Cells] 2022 Dec 02; Vol. 11 (23). Date of Electronic Publication: 2022 Dec 02.
Typ publikacji:
Journal Article
MeSH Terms:
Pancreatic Neoplasms*/pathology
Dihydropyridines*
Exosomes*/metabolism
Humans ; Neoplastic Processes ; Receptors, CCR2/genetics ; Receptors, CCR2/metabolism ; Aspartate Aminotransferase, Cytoplasmic/metabolism ; Pancreatic Neoplasms
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Dimerization misalignment in human glutamate-oxaloacetate transaminase variants is the primary factor for PLP release.
Autorzy:
Lee J; Department of Chemistry and Biochemistry, San Francisco State University, San Francisco, CA, United States of America.
Gokey T; Department of Chemistry and Biochemistry, San Francisco State University, San Francisco, CA, United States of America.
Ting D; Department of Biology, San Francisco State University, San Francisco, CA, United States of America.
He ZH; Department of Biology, San Francisco State University, San Francisco, CA, United States of America.
Guliaev AB; Department of Chemistry and Biochemistry, San Francisco State University, San Francisco, CA, United States of America.
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Źródło:
PloS one [PLoS One] 2018 Sep 12; Vol. 13 (9), pp. e0203889. Date of Electronic Publication: 2018 Sep 12 (Print Publication: 2018).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Aspartate Aminotransferase, Cytoplasmic/*genetics
Aspartate Aminotransferase, Cytoplasmic/*physiology
Pyridoxal Phosphate/*metabolism
Amino Acid Substitution/genetics ; Aspartate Aminotransferase, Cytoplasmic/ultrastructure ; Aspartate Aminotransferases/metabolism ; Binding Sites/genetics ; Catalysis ; Catalytic Domain ; Computer Simulation ; Dimerization ; Glutamates/genetics ; Glutamates/physiology ; Humans ; Models, Molecular ; Molecular Dynamics Simulation ; Oxaloacetates/metabolism ; Principal Component Analysis ; Protein Domains/genetics ; Pyridoxal Phosphate/chemistry ; Pyridoxal Phosphate/physiology ; Vitamin B 6/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Glutamate is an essential mediator in glutamine-amplified insulin secretion.
Autorzy:
Han G; Division of Metabolism and Disease, Department of Biophysics, Kobe University Graduate School of Health Sciences, Kobe, Japan.; Division of Molecular and Metabolic Medicine, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe, Japan.; Kansai Electric Power Medical Research Institute, Kobe, Japan.
Takahashi H; Division of Molecular and Metabolic Medicine, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe, Japan.
Murao N; Division of Molecular and Metabolic Medicine, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe, Japan.
Gheni G; Division of Molecular and Metabolic Medicine, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe, Japan.
Yokoi N; Division of Molecular and Metabolic Medicine, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe, Japan.; Laboratory of Animal Breeding and Genetics, Graduate School of Agriculture, Kyoto University, Kyoto, Japan.
Hamamoto Y; Kansai Electric Power Medical Research Institute, Kobe, Japan.
Asahara SI; Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Seino Y; Kansai Electric Power Medical Research Institute, Kobe, Japan.
Kido Y; Division of Metabolism and Disease, Department of Biophysics, Kobe University Graduate School of Health Sciences, Kobe, Japan.; Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Seino S; Division of Molecular and Metabolic Medicine, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe, Japan.
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Źródło:
Journal of diabetes investigation [J Diabetes Investig] 2021 Jun; Vol. 12 (6), pp. 920-930. Date of Electronic Publication: 2021 Feb 17.
Typ publikacji:
Journal Article
MeSH Terms:
Glutamic Acid/*metabolism
Glutamine/*metabolism
Insulin Secretion/*physiology
Insulin-Secreting Cells/*metabolism
Animals ; Aspartate Aminotransferase, Cytoplasmic ; Cells, Cultured ; Glucose/metabolism ; Glutamate Dehydrogenase ; Insulin/metabolism ; Islets of Langerhans/cytology ; Mice ; Signal Transduction
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Mechanical stretching stimulates collagen synthesis via down-regulating SO2/AAT1 pathway.
Autorzy:
Liu J; Department of Pediatrics, Peking University First Hospital, Beijing 100034, P. R. China.
Yu W; Department of Pediatrics, Peking University First Hospital, Beijing 100034, P. R. China.
Liu Y; Anzhen Hospital, Capital Medical University, Beijing 100020, P. R. China.
Chen S; University of California, San Diego, La Jolla, California, 92093, United States of America.
Huang Y; Department of Pediatrics, Peking University First Hospital, Beijing 100034, P. R. China.
Li X; Department of Cardiovascular Pediatrics, Capital Institute of Pediatrics, Beijing 100020, P. R. China.
Liu C; Department of Pediatrics, Tianjin Fifth Centre Hospital, Tianjin 300450, P. R. China.
Zhang Y; Department of Pediatrics, The Hospital of Shunyi District Beijing, Beijing 101300, P. R. China.
Li Z; Department of Pediatrics, Peking University First Hospital, Beijing 100034, P. R. China.
Du J; Anzhen Hospital, Capital Medical University, Beijing 100020, P. R. China.; Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education (2014XXGB02).
Tang C; Department of Physiology and Pathophysiology, Peking University Health Science Centre, Beijing 100191, P. R. China.; Key Laboratory of Molecular Cardiology, Ministry of Education, Beijing 100191, P. R. China.
Du J; Department of Pediatrics, Peking University First Hospital, Beijing 100034, P. R. China.; Key Laboratory of Molecular Cardiology, Ministry of Education, Beijing 100191, P. R. China.
Jin H; Department of Pediatrics, Peking University First Hospital, Beijing 100034, P. R. China.; Anzhen Hospital, Capital Medical University, Beijing 100020, P. R. China.
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Źródło:
Scientific reports [Sci Rep] 2016 Feb 16; Vol. 6, pp. 21112. Date of Electronic Publication: 2016 Feb 16.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Mechanotransduction, Cellular*
Signal Transduction*
Aspartate Aminotransferase, Cytoplasmic/*metabolism
Collagen/*biosynthesis
Sulfur Dioxide/*metabolism
Animals ; Aspartate Aminotransferase, Cytoplasmic/genetics ; Fibroblasts/metabolism ; Gene Knockdown Techniques ; Lung/cytology ; Lung/metabolism ; Rats ; Smad2 Protein/metabolism ; Smad3 Protein/metabolism ; Transforming Growth Factor beta1/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Chronic dysfunction of Stromal interaction molecule by pulsed RNAi induction in fat tissue impairs organismal energy homeostasis in Drosophila.
Autorzy:
Xu Y; Max-Planck-Institut für biophysikalische Chemie, Research Group Molecular Physiology, Am Faβberg 11, D-37077, Göttingen, Germany. .; Max-Planck-Institut für biophysikalische Chemie, Department of Molecular Developmental Biology, Am Faβberg 11, D-37077, Göttingen, Germany. .; Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, D-85764, Neuherberg, München, Germany. .
Borcherding AF; Max-Planck-Institut für biophysikalische Chemie, Research Group Molecular Physiology, Am Faβberg 11, D-37077, Göttingen, Germany.
Heier C; University of Graz, Institute of Molecular Biosciences, Humboldtstrasse 50/2.OG, A-8010, Graz, Austria.
Tian G; Christian-Albrechts University Kiel, Zoology, Molecular Physiology, 24098, Kiel, Germany.; Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL), Kiel, Germany.
Roeder T; Christian-Albrechts University Kiel, Zoology, Molecular Physiology, 24098, Kiel, Germany.; Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL), Kiel, Germany.
Kühnlein RP; Max-Planck-Institut für biophysikalische Chemie, Research Group Molecular Physiology, Am Faβberg 11, D-37077, Göttingen, Germany. .; University of Graz, Institute of Molecular Biosciences, Humboldtstrasse 50/2.OG, A-8010, Graz, Austria. .; BioTechMed Graz, Graz, Austria. .
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Źródło:
Scientific reports [Sci Rep] 2019 May 06; Vol. 9 (1), pp. 6989. Date of Electronic Publication: 2019 May 06.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Adipose Tissue/*metabolism
Calcium/*metabolism
Drosophila Proteins/*genetics
Hyperphagia/*genetics
Insect Hormones/*genetics
Obesity/*genetics
Oligopeptides/*genetics
Pyrrolidonecarboxylic Acid/*analogs & derivatives
Stromal Interaction Molecule 1/*genetics
Adipose Tissue/pathology ; Animals ; Aspartate Aminotransferase, Cytoplasmic/genetics ; Aspartate Aminotransferase, Cytoplasmic/metabolism ; Calcium Signaling ; Calcium-Binding Proteins/genetics ; Calcium-Binding Proteins/metabolism ; Disease Models, Animal ; Drosophila Proteins/antagonists & inhibitors ; Drosophila Proteins/metabolism ; Drosophila melanogaster ; Energy Metabolism/genetics ; Female ; Gene Expression Regulation ; Homeostasis/genetics ; Humans ; Hyperphagia/metabolism ; Hyperphagia/pathology ; Insect Hormones/metabolism ; Ion Transport ; Isoenzymes/genetics ; Isoenzymes/metabolism ; Lipid Metabolism/genetics ; Malate Dehydrogenase/genetics ; Malate Dehydrogenase/metabolism ; Male ; Obesity/metabolism ; Obesity/pathology ; Oligopeptides/metabolism ; Pyrrolidonecarboxylic Acid/metabolism ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Stromal Interaction Molecule 1/antagonists & inhibitors ; Stromal Interaction Molecule 1/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A maternal GOT1 novel variant associated with early-onset severe preeclampsia identified by whole-exome sequencing.
Autorzy:
Zhang L; Department of Internal Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Chaoyang, Beijing, 100026, China.
Cao Z; Department of Laboratory Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Chaoyang, Beijing, 100026, China.
Feng F; Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Haidian, Beijing, 100084, China.
Xu YN; Department of Internal Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Chaoyang, Beijing, 100026, China.
Li L; Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Chaoyang, Beijing, 100026, China. .
Gao H; Department of Internal Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Chaoyang, Beijing, 100026, China. .
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Źródło:
BMC medical genetics [BMC Med Genet] 2020 Mar 06; Vol. 21 (1), pp. 49. Date of Electronic Publication: 2020 Mar 06.
Typ publikacji:
Case Reports; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Polymorphism, Single Nucleotide*
Aspartate Aminotransferase, Cytoplasmic/*genetics
Pre-Eclampsia/*genetics
Adult ; Age of Onset ; Cohort Studies ; Female ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Gestational Age ; Humans ; Pre-Eclampsia/epidemiology ; Pre-Eclampsia/pathology ; Pregnancy ; Severity of Illness Index ; Exome Sequencing
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Blood-Based Glutamate Scavengers Reverse Traumatic Brain Injury-Induced Synaptic Plasticity Disruption by Decreasing Glutamate Level in Hippocampus Interstitial Fluid, but Not Cerebral Spinal Fluid, In Vivo.
Autorzy:
Zhang D; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.; Henan Key Laboratory of Neural Regeneration and Repairment, The First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan, China.
Xiao M; Henan Key Laboratory of Neural Regeneration and Repairment, The First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan, China.
Wang L; Henan Key Laboratory of Neural Regeneration and Repairment, The First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan, China.
Jia W; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. .; China National Clinical Research Center for Neurological Diseases (NCRC-ND), Beijing, China. .
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Źródło:
Neurotoxicity research [Neurotox Res] 2019 Feb; Vol. 35 (2), pp. 360-372. Date of Electronic Publication: 2018 Sep 25.
Typ publikacji:
Journal Article
MeSH Terms:
Brain Injuries, Traumatic/*blood
Extracellular Fluid/*metabolism
Free Radical Scavengers/*blood
Glutamic Acid/*blood
Hippocampus/*metabolism
Neuronal Plasticity/*physiology
Animals ; Aspartate Aminotransferase, Cytoplasmic/blood ; Aspartate Aminotransferase, Cytoplasmic/pharmacology ; Aspartate Aminotransferase, Cytoplasmic/therapeutic use ; Biomarkers/blood ; Brain Injuries, Traumatic/drug therapy ; Excitatory Postsynaptic Potentials/drug effects ; Excitatory Postsynaptic Potentials/physiology ; Extracellular Fluid/drug effects ; Hippocampus/drug effects ; Male ; Neuronal Plasticity/drug effects ; Rats ; Rats, Wistar
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Acrolein modifies and inhibits cytosolic aspartate aminotransferase.
Autorzy:
Southwell JL; Department of Biochemistry, University of Health Sciences, Kansas City, MO 64106-1453, USA.
Yeargans GS
Kowalewski C
Seidler NW
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2002 Feb; Vol. 17 (1), pp. 19-23.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Acrolein/*pharmacology
Aspartate Aminotransferase, Cytoplasmic/*antagonists & inhibitors
Acrolein/chemistry ; Animals ; Aspartate Aminotransferase, Cytoplasmic/chemistry ; Cross-Linking Reagents ; Ischemia/metabolism ; Protein Conformation/drug effects ; Protein Denaturation/drug effects ; Protein Subunits ; Swine ; Temperature
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
2‑Deoxy‑D‑glucose initiates hepatocyte differentiation in human induced pluripotent stem cells.
Autorzy:
Tomizawa M; Department of Gastroenterology, National Hospital Organization, Shimoshizu Hospital, Yotsukaido, Chiba 284‑0003, Japan.
Shinozaki F; Department of Radiology, National Hospital Organization, Shimoshizu Hospital, Yotsukaido, Chiba 284‑0003, Japan.
Motoyoshi Y; Department of Neurology, National Hospital Organization, Shimoshizu Hospital, Yotsukaido, Chiba 284‑0003, Japan.
Sugiyama T; Department of Rheumatology, National Hospital Organization, Shimoshizu Hospital, Yotsukaido, Chiba 284‑0003, Japan.
Yamamoto S; Department of Pediatrics, National Hospital Organization, Shimoshizu Hospital, Yotsukaido, Chiba 284‑0003, Japan.
Ishige N; Department of Neurosurgery, National Hospital Organization, Shimoshizu Hospital, Yotsukaido, Chiba 284‑0003, Japan.
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Źródło:
Molecular medicine reports [Mol Med Rep] 2017 May; Vol. 15 (5), pp. 3083-3087. Date of Electronic Publication: 2017 Mar 28.
Typ publikacji:
Journal Article
MeSH Terms:
Cell Differentiation/*drug effects
Deoxyglucose/*pharmacology
Hepatocytes/*cytology
Hepatocytes/*drug effects
Induced Pluripotent Stem Cells/*cytology
Induced Pluripotent Stem Cells/*drug effects
Alanine Transaminase/metabolism ; Aspartate Aminotransferase, Cytoplasmic/metabolism ; Aspartate Aminotransferase, Mitochondrial/metabolism ; Cell Line ; Galactose/metabolism ; Glucose/metabolism ; Glycerol Kinase/metabolism ; Glycogen Synthase/metabolism ; Hepatocytes/metabolism ; Humans ; Induced Pluripotent Stem Cells/metabolism ; Oncostatin M/pharmacology ; RNA, Messenger/metabolism ; Real-Time Polymerase Chain Reaction/methods ; alpha-Fetoproteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Mutant KRAS associated malic enzyme 1 expression is a predictive marker for radiation therapy response in non-small cell lung cancer.
Autorzy:
Chakrabarti G; Departments of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390, USA. .; Departments of Radiation Oncology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390, USA. .; Departments of Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390, USA. .; University of Texas Southwestern Medical Center, 6001 Forest Park Drive, ND 2.210, Dallas, TX, 75390-8807, USA. .
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Źródło:
Radiation oncology (London, England) [Radiat Oncol] 2015 Jul 16; Vol. 10, pp. 145. Date of Electronic Publication: 2015 Jul 16.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Genes, ras*
Carcinoma, Non-Small-Cell Lung/*radiotherapy
Lung Neoplasms/*radiotherapy
Malate Dehydrogenase/*biosynthesis
Neoplasm Proteins/*biosynthesis
Animals ; Aspartate Aminotransferase, Cytoplasmic/biosynthesis ; Aspartate Aminotransferase, Cytoplasmic/genetics ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/mortality ; Carcinoma, Non-Small-Cell Lung/pathology ; Cell Line, Tumor ; Databases, Factual ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic/genetics ; Glutamine/metabolism ; Humans ; Kaplan-Meier Estimate ; Lung Neoplasms/genetics ; Lung Neoplasms/mortality ; Lung Neoplasms/pathology ; Malate Dehydrogenase/analysis ; Malate Dehydrogenase/genetics ; Mice ; Mice, Transgenic ; Mutation, Missense ; NADP/metabolism ; Neoplasm Proteins/analysis ; Neoplasm Proteins/genetics ; Oxidation-Reduction ; Point Mutation ; Prognosis ; RNA Interference ; RNA, Messenger/biosynthesis ; RNA, Neoplasm/biosynthesis ; RNA, Small Interfering/genetics ; Radiation Tolerance/genetics ; Recombinant Fusion Proteins/biosynthesis ; Tumor Stem Cell Assay ; Up-Regulation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Genome-wide association study identifies genetic variants in GOT1 determining serum aspartate aminotransferase levels.
Autorzy:
Shen H; Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA. />Damcott C
Shuldiner SR
Chai S
Yang R
Hu H
Gibson Q
Ryan KA
Mitchell BD
Gong DW
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Źródło:
Journal of human genetics [J Hum Genet] 2011 Nov; Vol. 56 (11), pp. 801-5. Date of Electronic Publication: 2011 Sep 08.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Genome-Wide Association Study*
Polymorphism, Single Nucleotide*
Aspartate Aminotransferase, Cytoplasmic/*blood
Aspartate Aminotransferase, Cytoplasmic/*genetics
Adult ; Amino Acid Sequence ; Amish/genetics ; Base Sequence ; Female ; Genotype ; HEK293 Cells ; Humans ; Male ; Middle Aged ; Molecular Sequence Data ; Mutation ; Sequence Alignment
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Heavy ethanol intoxication increases proinflammatory cytokines and aggravates hemorrhagic shock-induced organ damage in rats.
Autorzy:
Hu TM; Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan ; Department of Psychiatry, Yuli Veterans Hospital, Hualien, Taiwan.
Lee RP
Lee CJ
Subeq YM
Lin NT
Hsu BG
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Źródło:
Mediators of inflammation [Mediators Inflamm] 2013; Vol. 2013, pp. 121786. Date of Electronic Publication: 2013 Sep 12.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Alcoholic Intoxication*
Cytokines/*blood
Ethanol/*toxicity
Shock, Hemorrhagic/*physiopathology
Alanine Transaminase/blood ; Animals ; Arterial Pressure ; Aspartate Aminotransferase, Cytoplasmic/blood ; Aspartate Aminotransferases/blood ; Blood Urea Nitrogen ; Creatinine/blood ; Enzyme-Linked Immunosorbent Assay ; Ethanol/blood ; Gene Expression Regulation ; Heart Rate ; Hemoglobins/metabolism ; Inflammation ; Interleukin-6/blood ; L-Lactate Dehydrogenase/blood ; Male ; Multiple Organ Failure/etiology ; Rats ; Rats, Inbred WKY ; Time Factors ; Tumor Necrosis Factor-alpha/blood
Czasopismo naukowe
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Tytuł:
The promoter for C4-type mitochondrial aspartate aminotransferase does not direct bundle sheath-specific expression in transgenic rice plants.
Autorzy:
Nomura M; Faculty of Agriculture, Kagawa University, Miki, Kita, Kagawa, 761-0795 Japan.
Higuchi T
Katayama K
Taniguchi M
Miyao-Tokutomi M
Matsuoka M
Tajima S
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Źródło:
Plant & cell physiology [Plant Cell Physiol] 2005 May; Vol. 46 (5), pp. 743-53. Date of Electronic Publication: 2005 Mar 07.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Aspartate Aminotransferase, Mitochondrial/*genetics
Gene Expression Regulation, Plant/*genetics
Mitochondria/*enzymology
Oryza/*enzymology
Plants, Genetically Modified/*enzymology
Promoter Regions, Genetic/*genetics
Aspartate Aminotransferase, Cytoplasmic/genetics ; Aspartate Aminotransferase, Cytoplasmic/metabolism ; Genes, Reporter/genetics ; Light ; Mitochondria/genetics ; Oryza/genetics ; Oryza/growth & development ; Panicum/enzymology ; Panicum/genetics ; Photic Stimulation ; Photosynthesis/genetics ; Plant Shoots/enzymology ; Plant Shoots/genetics ; Plant Shoots/growth & development ; Plants, Genetically Modified/genetics ; Plants, Genetically Modified/growth & development ; Species Specificity
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
SNPs in the porcine GOT1 gene improve a QTL for serum aspartate aminotransferase activity on SSC14.
Autorzy:
Reiner G; Department of Veterinary Clinical Sciences, Justus-Liebig-University, D-35392 Giessen, Germany. />Clemens N
Lohner E
Willems H
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Źródło:
Animal genetics [Anim Genet] 2010 Jun; Vol. 41 (3), pp. 319-23. Date of Electronic Publication: 2009 Nov 26.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Polymorphism, Single Nucleotide*
Quantitative Trait Loci*
Aspartate Aminotransferase, Cytoplasmic/*genetics
Aspartate Aminotransferases/*genetics
Sus scrofa/*genetics
Animals ; Female ; Male
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 24

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