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Wyszukujesz frazę ""Aspartic Acid Endopeptidases"" wg kryterium: Temat


Tytuł :
Physiological functions of SPP/SPPL intramembrane proteases.
Autorzy :
Mentrup T; Institute for Physiological Chemistry, Medizinisch-Theoretisches Zentrum MTZ, Technische Universität Dresden, Fiedlerstraße 42, 01307, Dresden, Germany.
Cabrera-Cabrera F; Institute for Physiological Chemistry, Medizinisch-Theoretisches Zentrum MTZ, Technische Universität Dresden, Fiedlerstraße 42, 01307, Dresden, Germany.
Fluhrer R; Biochemistry and Molecular Biology, Faculty of Medicine, University of Augsburg, Universitätsstraße 2, 86135, Augsburg, Germany.; Biomedizinisches Centrum (BMC), Ludwig Maximilians University of Munich, Feodor-Lynen-Strasse 17, 81377, Munich, Germany.; DZNE-German Center for Neurodegenerative Diseases, Munich, Feodor-Lynen-Strasse 17, 81377, Munich, Germany.
Schröder B; Institute for Physiological Chemistry, Medizinisch-Theoretisches Zentrum MTZ, Technische Universität Dresden, Fiedlerstraße 42, 01307, Dresden, Germany. .
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Źródło :
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2020 Aug; Vol. 77 (15), pp. 2959-2979. Date of Electronic Publication: 2020 Feb 12.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Aspartic Acid Endopeptidases/*metabolism
Amyloid Precursor Protein Secretases/metabolism ; Animals ; Aspartic Acid Endopeptidases/chemistry ; Humans ; Membrane Proteins/metabolism ; Protein Transport ; Proteolysis ; Signal Transduction ; Substrate Specificity
Czasopismo naukowe
Tytuł :
Sex differences in circulating neuregulin1-β1 and β-secretase 1 expression in childhood-onset schizophrenia.
Autorzy :
Zhang Z; National Clinical Research Center for Mental Disorders, Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing 100088, China.
Li Y; Beijing Institute for Brain Disorders, Capital Medical University, Beijing 100069, China.
He F; National Clinical Research Center for Mental Disorders, Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing 100088, China.
Cui Y; National Clinical Research Center for Mental Disorders, Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing 100088, China.
Zheng Y; National Clinical Research Center for Mental Disorders, Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing 100088, China. Electronic address: .
Li R; National Clinical Research Center for Mental Disorders, Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing 100088, China; Beijing Institute for Brain Disorders, Capital Medical University, Beijing 100069, China. Electronic address: .
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Źródło :
Comprehensive psychiatry [Compr Psychiatry] 2020 Jul; Vol. 100, pp. 152176. Date of Electronic Publication: 2020 Apr 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amyloid Precursor Protein Secretases/*blood
Aspartic Acid Endopeptidases/*blood
Neuregulin-1/*blood
Schizophrenia/*blood
Adolescent ; Age of Onset ; Amyloid Precursor Protein Secretases/metabolism ; Aspartic Acid Endopeptidases/metabolism ; Biomarkers/blood ; Case-Control Studies ; Child ; Female ; Humans ; Male ; Schizophrenia/etiology ; Schizophrenia/metabolism ; Sex Factors ; Signal Transduction ; Young Adult
Czasopismo naukowe
Tytuł :
BACE2 degradation is mediated by both the proteasome and lysosome pathways.
Autorzy :
Qiu K; Cheeloo College of Medicine, Shandong University, 44 Wenhua West Road, LixiaDistrict, Jinan, Shandong, China.; Shandong Collaborative Innovation Center for Diagnosis, Treatment and Behavioral Interventions of mental disorders, Institute of Mental Health, Jining Medical University, 133 Hehua Road, Taibaihu New District, Jining, 272067, Shandong, China.; Shandong Key Laboratory of Behavioral Medicine, School of Mental Health, Jining Medical University, 133 Hehua Road, Taibaihu New District, Jining, Shandong, China.
Liang W; The National Clinical Research Center for Geriatric Disease, Xuanwu Hospital, Capital Medical University, Beijing, China.; Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China.
Wang S; Shandong Collaborative Innovation Center for Diagnosis, Treatment and Behavioral Interventions of mental disorders, Institute of Mental Health, Jining Medical University, 133 Hehua Road, Taibaihu New District, Jining, 272067, Shandong, China.; Shandong Key Laboratory of Behavioral Medicine, School of Mental Health, Jining Medical University, 133 Hehua Road, Taibaihu New District, Jining, Shandong, China.
Kong T; Cheeloo College of Medicine, Shandong University, 44 Wenhua West Road, LixiaDistrict, Jinan, Shandong, China.
Wang X; Shandong Collaborative Innovation Center for Diagnosis, Treatment and Behavioral Interventions of mental disorders, Institute of Mental Health, Jining Medical University, 133 Hehua Road, Taibaihu New District, Jining, 272067, Shandong, China.; Shandong Key Laboratory of Behavioral Medicine, School of Mental Health, Jining Medical University, 133 Hehua Road, Taibaihu New District, Jining, Shandong, China.
Li C; Cheeloo College of Medicine, Shandong University, 44 Wenhua West Road, LixiaDistrict, Jinan, Shandong, China.; Shandong Collaborative Innovation Center for Diagnosis, Treatment and Behavioral Interventions of mental disorders, Institute of Mental Health, Jining Medical University, 133 Hehua Road, Taibaihu New District, Jining, 272067, Shandong, China.; Shandong Key Laboratory of Behavioral Medicine, School of Mental Health, Jining Medical University, 133 Hehua Road, Taibaihu New District, Jining, Shandong, China.
Wang Z; The National Clinical Research Center for Geriatric Disease, Xuanwu Hospital, Capital Medical University, Beijing, China.; Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China.
Wu Y; Shandong Collaborative Innovation Center for Diagnosis, Treatment and Behavioral Interventions of mental disorders, Institute of Mental Health, Jining Medical University, 133 Hehua Road, Taibaihu New District, Jining, 272067, Shandong, China. .; Shandong Key Laboratory of Behavioral Medicine, School of Mental Health, Jining Medical University, 133 Hehua Road, Taibaihu New District, Jining, Shandong, China. .
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Źródło :
BMC molecular and cell biology [BMC Mol Cell Biol] 2020 Mar 11; Vol. 21 (1), pp. 13. Date of Electronic Publication: 2020 Mar 11.
Typ publikacji :
Journal Article
MeSH Terms :
Amyloid Precursor Protein Secretases/*metabolism
Aspartic Acid Endopeptidases/*metabolism
Lysosomes/*enzymology
Proteasome Endopeptidase Complex/*metabolism
Amyloid Precursor Protein Secretases/genetics ; Animals ; Aspartic Acid Endopeptidases/genetics ; HEK293 Cells ; Half-Life ; Humans ; Lysosomes/drug effects ; Lysosomes/metabolism ; Mice ; Neurons/enzymology ; Neurons/metabolism ; Neurons/pathology ; Proteasome Endopeptidase Complex/drug effects
Czasopismo naukowe
Tytuł :
Overexpression of Arabidopsis aspartic protease APA1 gene confers drought tolerance.
Autorzy :
Sebastián D; Biological Research Institute, National Council of Scientific and Technique Research (CONICET), University of Mar del Plata, Mar del Plata (UNMDP), Argentina.
Fernando FD; Biological Research Institute, National Council of Scientific and Technique Research (CONICET), University of Mar del Plata, Mar del Plata (UNMDP), Argentina.
Raúl DG; Biological Research Institute, National Council of Scientific and Technique Research (CONICET), University of Mar del Plata, Mar del Plata (UNMDP), Argentina.
Gabriela GM; Biological Research Institute, National Council of Scientific and Technique Research (CONICET), University of Mar del Plata, Mar del Plata (UNMDP), Argentina. Electronic address: .
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Źródło :
Plant science : an international journal of experimental plant biology 2020 Mar; Vol. 292, pp. 110406. Date of Electronic Publication: 2020 Jan 07.
Typ publikacji :
Journal Article
MeSH Terms :
Droughts*
Gene Expression Regulation, Plant*
Signal Transduction*
Abscisic Acid/*metabolism
Arabidopsis/*physiology
Arabidopsis Proteins/*genetics
Aspartic Acid Endopeptidases/*genetics
Acclimatization ; Arabidopsis/genetics ; Arabidopsis Proteins/metabolism ; Aspartic Acid Endopeptidases/metabolism
Czasopismo naukowe
Tytuł :
A Novel Dual Fluorochrome Near-Infrared Imaging Probe for Potential Alzheimer's Enzyme Biomarkers-BACE1 and Cathepsin D.
Autorzy :
Tam JM; Wyss Institute and Harvard Medical School, Boston, MA 02115, USA.
Josephson L; Center for Molecular Imaging Research (CMIR), Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
Pilozzi AR; Neurochemistry Laboratory, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
Huang X; Neurochemistry Laboratory, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2020 Jan 09; Vol. 25 (2). Date of Electronic Publication: 2020 Jan 09.
Typ publikacji :
Journal Article
MeSH Terms :
Molecular Imaging*
Alzheimer Disease/*diagnosis
Amyloid Precursor Protein Secretases/*chemistry
Aspartic Acid Endopeptidases/*chemistry
Cathepsin D/*chemistry
Alzheimer Disease/genetics ; Amino Acid Sequence/genetics ; Amyloid Precursor Protein Secretases/genetics ; Amyloid Precursor Protein Secretases/isolation & purification ; Amyloid beta-Protein Precursor/chemistry ; Amyloid beta-Protein Precursor/genetics ; Amyloid beta-Protein Precursor/isolation & purification ; Aspartic Acid Endopeptidases/genetics ; Aspartic Acid Endopeptidases/isolation & purification ; Biomarkers/chemistry ; Cathepsin D/genetics ; Cathepsin D/isolation & purification ; Fluorescent Dyes/chemistry ; Fluorescent Dyes/isolation & purification ; Humans
Czasopismo naukowe
Tytuł :
Tau deletion reduces plaque-associated BACE1 accumulation and decelerates plaque formation in a mouse model of Alzheimer's disease.
Autorzy :
Peters F; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Munich Cluster of Systems Neurology (SyNergy), Munich, Germany.
Salihoglu H; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Munich Cluster of Systems Neurology (SyNergy), Munich, Germany.
Pratsch K; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.
Herzog E; IINS, UMR 5297, Université Bordeaux, Bordeaux, France.; CNRS, IINS, UMR 5297, Bordeaux, France.
Pigoni M; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Munich Cluster of Systems Neurology (SyNergy), Munich, Germany.
Sgobio C; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.
Lichtenthaler SF; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Munich Cluster of Systems Neurology (SyNergy), Munich, Germany.; Neuroproteomics, School of Medicine, Klinikum rechts der Isar and Institute for Advanced Study, Technical University of Munich, Munich, Germany.
Neumann U; Neuroscience, Novartis Institutes for BioMedical Research (NIBR), Basel, Switzerland.
Herms J; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Munich Cluster of Systems Neurology (SyNergy), Munich, Germany.; Center for Neuropathology and Prion Research, Ludwig-Maximilians University, Munich, Germany.
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Źródło :
The EMBO journal [EMBO J] 2019 Dec 02; Vol. 38 (23), pp. e102345. Date of Electronic Publication: 2019 Nov 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation*
Alzheimer Disease/*prevention & control
Amyloid Precursor Protein Secretases/*physiology
Aspartic Acid Endopeptidases/*antagonists & inhibitors
Plaque, Amyloid/*prevention & control
tau Proteins/*antagonists & inhibitors
Alzheimer Disease/etiology ; Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Amyloid Precursor Protein Secretases/antagonists & inhibitors ; Amyloid Precursor Protein Secretases/genetics ; Amyloid Precursor Protein Secretases/metabolism ; Animals ; Aspartic Acid Endopeptidases/genetics ; Aspartic Acid Endopeptidases/metabolism ; Brain/metabolism ; Brain/pathology ; Disease Models, Animal ; Female ; Humans ; Male ; Mice ; Mice, Transgenic ; Plaque, Amyloid/etiology ; Plaque, Amyloid/metabolism ; Plaque, Amyloid/pathology
Czasopismo naukowe
Tytuł :
Mouse brain proteomics establishes MDGA1 and CACHD1 as in vivo substrates of the Alzheimer protease BACE1.
Autorzy :
Rudan Njavro J; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Neuroproteomics, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Klotz J; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Neuroproteomics, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Dislich B; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Institute of Pathology, University of Bern, Switzerland.
Wanngren J; Division of Neurogeriatrics, Department of NVS, Center for Alzheimer Research, Karolinska Institutet, Stockholm, Sweden.
Shmueli MD; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Neuroproteomics, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.; Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel.
Herber J; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Neuroproteomics, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Kuhn PH; Institute of Pathology, Technical University of Munich, Munich, Germany.
Kumar R; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; School of Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.; Department of Neurology, Ludwig Maximilian University of Munich, Munich, Germany.
Koeglsperger T; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Department of Neurology, Ludwig Maximilian University of Munich, Munich, Germany.
Conrad M; Institute of Developmental Genetics, Helmholtz Zentrum München, Neuherberg, Germany.
Wurst W; Institute of Developmental Genetics, Helmholtz Zentrum München, Neuherberg, Germany.; Genome Engineering, German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Developmental Genetics, School of Life Sciences Weihenstephan, Technical University of Munich, Freising, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
Feederle R; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.; German Research Center for Environmental Health, Institute for Diabetes and Obesity, Monoclonal Antibody Core Facility, Helmholtz Zentrum München, Neuherberg, Germany.; Core Facility Monoclonal Antibodies, German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.
Vlachos A; Department of Neuroanatomy, Institute of Anatomy and Cell Biology, Faculty of Medicine, University of Freiburg, Germany.; Center for Basics in Neuromodulation (NeuroModulBasics), Faculty of Medicine, University of Freiburg, Germany.
Michalakis S; Department of Ophthalmology, Ludwig Maximilian University of Munich, Munich, Germany.
Jedlicka P; Faculty of Medicine, ICAR3R - Interdisciplinary Centre for 3Rs in Animal Research, Justus-Liebig-University, Giessen, Germany.; Neuroscience Center, Institute of Clinical Neuroanatomy, Goethe University, Frankfurt am Main, Germany.; Frankfurt Institute for Advanced Studies, Frankfurt am Main, Germany.
Müller SA; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Neuroproteomics, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Lichtenthaler SF; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Neuroproteomics, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
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Źródło :
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2020 Feb; Vol. 34 (2), pp. 2465-2482. Date of Electronic Publication: 2019 Dec 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Proteomics*
Amyloid Precursor Protein Secretases/*metabolism
Aspartic Acid Endopeptidases/*metabolism
Brain/*metabolism
Neural Cell Adhesion Molecules/*metabolism
Alzheimer Disease/genetics ; Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Amyloid Precursor Protein Secretases/genetics ; Animals ; Aspartic Acid Endopeptidases/genetics ; Brain/pathology ; Mice ; Mice, Knockout ; Neural Cell Adhesion Molecules/genetics
Czasopismo naukowe
Tytuł :
Label-free quantitative proteomic analysis of the biological functions of Moringa oleifera seed proteins provides insights regarding the milk-clotting proteases.
Autorzy :
Wang X; College of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, Yunnan, China.
Shi Y; College of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, Yunnan, China.
He R; College of Food Science and Engineering, Nanjing University of Finance and Economics, Nanjing 210003, China.
Li B; College of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, Yunnan, China.
Huang A; College of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, Yunnan, China. Electronic address: .
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2020 Feb 01; Vol. 144, pp. 325-333. Date of Electronic Publication: 2019 Dec 10.
Typ publikacji :
Journal Article
MeSH Terms :
Proteomics*
Aspartic Acid Endopeptidases/*metabolism
Milk/*chemistry
Moringa oleifera/*enzymology
Animals ; Aspartic Acid Endopeptidases/isolation & purification ; Chromatography, Liquid ; Gene Ontology ; Hot Temperature ; Hydrogen-Ion Concentration ; Mass Spectrometry ; Moringa oleifera/chemistry ; Plant Proteins/isolation & purification ; Plant Proteins/metabolism ; Seeds/chemistry ; Seeds/enzymology
Czasopismo naukowe
Tytuł :
Potential role of Candida albicans secreted aspartic protease 9 in serum induced-hyphal formation and interaction with oral epithelial cells.
Autorzy :
Yang H; The Affiliated Stomatology Hospital, Zhejiang University School of Medicine, China; Key Laboratory of Oral Biomedical Research of Zhejiang Province, Zhejiang Univerisity School of Stomatology, China.
Tsang PCS; Department of Operative Dentistry, Faculty of Dentistry, The University of Hong Kong, Hong Kong.
Pow EHN; Department of Prosthodontics, Faculty of Dentistry, The University of Hong Kong, Hong Kong.
Lam OLT; Department of Prosthodontics, Faculty of Dentistry, The University of Hong Kong, Hong Kong.
Tsang PW; Technological and Higher Education Institute of Hong Kong, Hong Kong. Electronic address: .
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Źródło :
Microbial pathogenesis [Microb Pathog] 2020 Feb; Vol. 139, pp. 103896. Date of Electronic Publication: 2019 Nov 30.
Typ publikacji :
Journal Article
MeSH Terms :
Host-Pathogen Interactions*
Aspartic Acid Endopeptidases/*metabolism
Candida albicans/*physiology
Candidiasis, Oral/*metabolism
Candidiasis, Oral/*microbiology
Fungal Proteins/*metabolism
Mouth Mucosa/*metabolism
Mouth Mucosa/*microbiology
Aspartic Acid Endopeptidases/genetics ; Candidiasis, Oral/pathology ; Cell Line ; Fungal Proteins/genetics ; Gene Expression Regulation, Fungal ; Hyphae ; Mouth Mucosa/pathology ; Mutation
Czasopismo naukowe
Tytuł :
Expression Analysis of BDNF, BACE1, and Their Natural Occurring Antisenses in Autistic Patients.
Autorzy :
Ghafouri-Fard S; Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Namvar A; Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Arsang-Jang S; Clinical Research Development Center (CRDU), Qom University of Medical Sciences, Qom, Iran.
Komaki A; Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
Taheri M; Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. .
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Źródło :
Journal of molecular neuroscience : MN [J Mol Neurosci] 2020 Feb; Vol. 70 (2), pp. 194-200. Date of Electronic Publication: 2019 Nov 23.
Typ publikacji :
Journal Article
MeSH Terms :
Amyloid Precursor Protein Secretases/*genetics
Aspartic Acid Endopeptidases/*genetics
Autistic Disorder/*genetics
Brain-Derived Neurotrophic Factor/*genetics
Amyloid Precursor Protein Secretases/metabolism ; Aspartic Acid Endopeptidases/metabolism ; Autistic Disorder/blood ; Biomarkers/blood ; Blood Cells/metabolism ; Brain-Derived Neurotrophic Factor/metabolism ; Child ; Female ; Humans ; Male ; RNA, Antisense/blood ; RNA, Messenger/blood
Czasopismo naukowe
Tytuł :
Silencing of long noncoding RNA XIST attenuated Alzheimer's disease-related BACE1 alteration through miR-124.
Autorzy :
Yue D; Harbin Medical University Fourth Hospital, Neurology, Harbin, 150001, China.
Guanqun G; Harbin Medical University Fourth Hospital, Neurology, Harbin, 150001, China.
Jingxin L; Heilongjiang Provincial Hospital, Neurology, Harbin, Heilongjiang, 150030, China.
Sen S; Harbin Medical University Fourth Hospital, Neurology, Harbin, 150001, China.
Shuang L; Heilongjiang Provincial Hospital, Neurology, Harbin, Heilongjiang, 150030, China.
Yan S; Harbin Medical University Fourth Hospital, Neurology, Harbin, 150001, China.
Minxue Z; Harbin Medical University Fourth Hospital, Neurology, Harbin, 150001, China.
Ping Y; Heilongjiang Provincial Hospital, Neurology, Harbin, Heilongjiang, 150030, China.
Chong L; Heilongjiang Provincial Hospital, Neurology, Harbin, Heilongjiang, 150030, China.
Zhuobo Z; Harbin Medical University Fourth Hospital, Neurology, Harbin, 150001, China.
Yafen W; Heilongjiang Provincial Hospital, Neurology, Harbin, Heilongjiang, 150030, China.
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Źródło :
Cell biology international [Cell Biol Int] 2020 Feb; Vol. 44 (2), pp. 630-636. Date of Electronic Publication: 2019 Nov 26.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation*
Gene Silencing*
Alzheimer Disease/*prevention & control
Amyloid Precursor Protein Secretases/*metabolism
Aspartic Acid Endopeptidases/*metabolism
MicroRNAs/*genetics
Neuroblastoma/*prevention & control
RNA, Long Noncoding/*antagonists & inhibitors
Alzheimer Disease/etiology ; Alzheimer Disease/pathology ; Amyloid Precursor Protein Secretases/genetics ; Animals ; Apoptosis ; Aspartic Acid Endopeptidases/genetics ; Cell Proliferation ; Disease Models, Animal ; Mice ; Neuroblastoma/metabolism ; Neuroblastoma/pathology ; RNA, Long Noncoding/genetics ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
cGMP favors the interaction between APP and BACE1 by inhibiting Rab5 GTPase activity.
Autorzy :
Caudano F; Department of Experimental Medicine, University of Genoa, Genoa, Italy.
Montalto G; Department of Experimental Medicine, University of Genoa, Genoa, Italy.
Passalacqua M; Department of Experimental Medicine, University of Genoa, Genoa, Italy.
Pronzato MA; Department of Experimental Medicine, University of Genoa, Genoa, Italy.
Fedele E; Department of Pharmacy and Center of Excellence for Biomedical Research, University of Genoa, Genoa, Italy.; IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Ricciarelli R; Department of Experimental Medicine, University of Genoa, Genoa, Italy. .; IRCCS Ospedale Policlinico San Martino, Genoa, Italy. .
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Źródło :
Scientific reports [Sci Rep] 2020 Jan 28; Vol. 10 (1), pp. 1358. Date of Electronic Publication: 2020 Jan 28.
Typ publikacji :
Journal Article
MeSH Terms :
Second Messenger Systems*
Alzheimer Disease/*metabolism
Amyloid Precursor Protein Secretases/*metabolism
Amyloid beta-Protein Precursor/*metabolism
Aspartic Acid Endopeptidases/*metabolism
Cell Membrane/*metabolism
rab5 GTP-Binding Proteins/*metabolism
Alzheimer Disease/genetics ; Alzheimer Disease/pathology ; Amyloid Precursor Protein Secretases/genetics ; Amyloid beta-Protein Precursor/genetics ; Animals ; Aspartic Acid Endopeptidases/genetics ; Cell Line ; Cell Membrane/genetics ; Cell Membrane/pathology ; Cyclic GMP ; Endosomes/genetics ; Endosomes/metabolism ; Endosomes/pathology ; Mice ; rab5 GTP-Binding Proteins/genetics
Czasopismo naukowe
Tytuł :
Distinct anterograde trafficking pathways of BACE1 and amyloid precursor protein from the TGN and the regulation of amyloid-β production.
Autorzy :
Tan JZA; Department of Biochemistry and Molecular Biology and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Victoria 3010, Australia.
Fourriere L; Department of Biochemistry and Molecular Biology and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Victoria 3010, Australia.
Wang J; Department of Biochemistry and Molecular Biology and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Victoria 3010, Australia.
Perez F; Dynamics of Intracellular Organization Laboratory, Institut Curie, PSL Research University, Sorbonne Université, Centre National de la Recherche Scientifique, UMR 144, 75248 Paris, France.
Boncompain G; Dynamics of Intracellular Organization Laboratory, Institut Curie, PSL Research University, Sorbonne Université, Centre National de la Recherche Scientifique, UMR 144, 75248 Paris, France.
Gleeson PA; Department of Biochemistry and Molecular Biology and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Victoria 3010, Australia.
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Źródło :
Molecular biology of the cell [Mol Biol Cell] 2020 Jan 01; Vol. 31 (1), pp. 27-44. Date of Electronic Publication: 2019 Nov 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amyloid Precursor Protein Secretases/*metabolism
Amyloid beta-Protein Precursor/*metabolism
Aspartic Acid Endopeptidases/*metabolism
Protein Transport/*physiology
Alzheimer Disease/metabolism ; Amyloid Precursor Protein Secretases/physiology ; Amyloid beta-Peptides/metabolism ; Aspartic Acid Endopeptidases/physiology ; Cell Membrane/metabolism ; Cell Movement ; Endocytosis ; Endosomes/metabolism ; Golgi Apparatus/metabolism ; HeLa Cells ; Humans ; Neurons/metabolism ; trans-Golgi Network/metabolism ; trans-Golgi Network/physiology
Czasopismo naukowe
Tytuł :
Curcumin inhibits BACE1 expression through the interaction between ERβ and NFκB signaling pathway in SH-SY5Y cells.
Autorzy :
Huang P; Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, 430072, Hubei, People's Republic of China.
Zheng N; College of Bioengineering, Wuhan Polytechnic, Wuhan, 430072, Hubei, People's Republic of China.
Zhou HB; College of Pharmaceutical Sciences, Wuhan University, Wuhan, 430072, Hubei, People's Republic of China.
Huang J; Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, 430072, Hubei, People's Republic of China. .; Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Room 5105, Wuhan, 430072, Hubei, People's Republic of China. .
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Źródło :
Molecular and cellular biochemistry [Mol Cell Biochem] 2020 Jan; Vol. 463 (1-2), pp. 161-173. Date of Electronic Publication: 2019 Oct 08.
Typ publikacji :
Journal Article
MeSH Terms :
Alzheimer Disease/*drug therapy
Amyloid Precursor Protein Secretases/*metabolism
Aspartic Acid Endopeptidases/*metabolism
Curcumin/*pharmacology
Estrogen Receptor beta/*metabolism
NF-kappa B/*metabolism
Signal Transduction/*drug effects
Alzheimer Disease/genetics ; Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Amyloid Precursor Protein Secretases/genetics ; Aspartic Acid Endopeptidases/genetics ; Cell Line, Tumor ; Estrogen Receptor beta/genetics ; HEK293 Cells ; Humans ; NF-kappa B/genetics ; Signal Transduction/genetics
Czasopismo naukowe
Tytuł :
BACE1 partial deletion induces synaptic plasticity deficit in adult mice.
Autorzy :
Lombardo S; Alzheimer's Disease Research Laboratory, Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts, 02111, USA.; Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts, 02111, USA.
Chiacchiaretta M; Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts, 02111, USA.
Tarr A; Circuits and Behaviour Core, Center for Neuroscience Research, Tufts University School of Medicine, Boston, Massachusetts, 02111, USA.
Kim W; Alzheimer's Disease Research Laboratory, Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts, 02111, USA.; Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts, 02111, USA.
Cao T; Alzheimer's Disease Research Laboratory, Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts, 02111, USA.; Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts, 02111, USA.
Sigal G; Alzheimer's Disease Research Laboratory, Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts, 02111, USA.; Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts, 02111, USA.
Rosahl TW; External In Vivo Pharmacology, Merck & Co. Inc., Kenilworth, NJ, 07033, USA.
Xia W; Geriatric Research, Education and Clinic Center, Bedford Veterans Affairs Medical Center, Bedford, MA, 01730, USA.; Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, 02118, USA.
Haydon PG; Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts, 02111, USA.
Kennedy ME; Department of Neuroscience, Merck & Co. Inc, Boston, MA, 02115, USA.
Tesco G; Alzheimer's Disease Research Laboratory, Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts, 02111, USA. .; Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts, 02111, USA. .
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Źródło :
Scientific reports [Sci Rep] 2019 Dec 27; Vol. 9 (1), pp. 19877. Date of Electronic Publication: 2019 Dec 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
CA1 Region, Hippocampal*/enzymology
CA1 Region, Hippocampal*/pathology
Cerebral Cortex*/enzymology
Cerebral Cortex*/pathology
Gene Deletion*
Amyloid Precursor Protein Secretases/*deficiency
Aspartic Acid Endopeptidases/*deficiency
Axon Guidance/*genetics
Neuronal Plasticity/*genetics
Amyloid Precursor Protein Secretases/metabolism ; Amyloid beta-Peptides/genetics ; Amyloid beta-Peptides/metabolism ; Animals ; Aspartic Acid Endopeptidases/metabolism ; Mice ; Mice, Knockout
Czasopismo naukowe
Tytuł :
Inhibition of Plasmepsin V Activity Blocks Plasmodium falciparum Gametocytogenesis and Transmission to Mosquitoes.
Autorzy :
Jennison C; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, VIC, Australia; Department of Medical Biology, University of Melbourne, Parkville 3010, VIC, Australia.
Lucantoni L; Discovery Biology, Griffith Institute for Drug Discovery, Griffith University, Nathan 4111, QLD, Australia.
O'Neill MT; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, VIC, Australia.
McConville R; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, VIC, Australia; Department of Medical Biology, University of Melbourne, Parkville 3010, VIC, Australia.
Erickson SM; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, VIC, Australia; Department of Medical Biology, University of Melbourne, Parkville 3010, VIC, Australia.
Cowman AF; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, VIC, Australia; Department of Medical Biology, University of Melbourne, Parkville 3010, VIC, Australia.
Sleebs BE; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, VIC, Australia; Department of Medical Biology, University of Melbourne, Parkville 3010, VIC, Australia.
Avery VM; Discovery Biology, Griffith Institute for Drug Discovery, Griffith University, Nathan 4111, QLD, Australia.
Boddey JA; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, VIC, Australia; Department of Medical Biology, University of Melbourne, Parkville 3010, VIC, Australia. Electronic address: .
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Źródło :
Cell reports [Cell Rep] 2019 Dec 17; Vol. 29 (12), pp. 3796-3806.e4.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Aspartic Acid Endopeptidases/*antagonists & inhibitors
Culicidae/*growth & development
Enzyme Inhibitors/*pharmacology
Gametogenesis/*drug effects
Malaria, Falciparum/*prevention & control
Plasmodium falciparum/*growth & development
Protozoan Proteins/*antagonists & inhibitors
Animals ; Aspartic Acid Endopeptidases/metabolism ; Culicidae/drug effects ; Culicidae/parasitology ; Erythrocytes/drug effects ; Erythrocytes/parasitology ; Humans ; Life Cycle Stages ; Malaria, Falciparum/enzymology ; Malaria, Falciparum/parasitology ; Malaria, Falciparum/transmission ; Plasmodium falciparum/drug effects ; Plasmodium falciparum/enzymology ; Protozoan Proteins/metabolism
Czasopismo naukowe
Tytuł :
Synapsin 1 promotes Aβ generation via BACE1 modulation.
Autorzy :
Maesako M; MassGeneral Institute for Neurodegenerative Disease, Alzheimer's Disease Research Unit, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States of America.
Zoltowska KM; MassGeneral Institute for Neurodegenerative Disease, Alzheimer's Disease Research Unit, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States of America.
Berezovska O; MassGeneral Institute for Neurodegenerative Disease, Alzheimer's Disease Research Unit, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States of America.
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Źródło :
PloS one [PLoS One] 2019 Dec 12; Vol. 14 (12), pp. e0226368. Date of Electronic Publication: 2019 Dec 12 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Gene Expression Regulation*
Amyloid Precursor Protein Secretases/*metabolism
Amyloid beta-Peptides/*metabolism
Aspartic Acid Endopeptidases/*metabolism
Presenilin-1/*metabolism
Synapsins/*metabolism
Amyloid Precursor Protein Secretases/genetics ; Animals ; Aspartic Acid Endopeptidases/genetics ; Male ; Mice ; Mice, Inbred C57BL ; Presenilin-1/genetics ; Synapsins/genetics
Czasopismo naukowe
Tytuł :
Comparison of affinity ranking using AutoDock-GPU and MM-GBSA scores for BACE-1 inhibitors in the D3R Grand Challenge 4.
Autorzy :
El Khoury L; Department of Pharmaceutical Sciences, University of California, Irvine, Irvine, USA.
Santos-Martins D; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037-1000, USA.
Sasmal S; Department of Pharmaceutical Sciences, University of California, Irvine, Irvine, USA.
Eberhardt J; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037-1000, USA.
Bianco G; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037-1000, USA.
Ambrosio FA; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037-1000, USA.; Department of Health Sciences, 'Magna Græcia' University of Catanzaro, Campus 'S. Venuta', Viale Europa, 88100, Catanzaro, Italy.
Solis-Vasquez L; Embedded Systems and Applications Group, Technische Universität Darmstadt, Darmstadt, Germany.
Koch A; Embedded Systems and Applications Group, Technische Universität Darmstadt, Darmstadt, Germany.
Forli S; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037-1000, USA. .
Mobley DL; Department of Pharmaceutical Sciences, University of California, Irvine, Irvine, USA. .; Department of Chemistry, University of California, Irvine, 147 Bison Modular, Irvine, CA, 92697, USA. .
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Źródło :
Journal of computer-aided molecular design [J Comput Aided Mol Des] 2019 Dec; Vol. 33 (12), pp. 1011-1020. Date of Electronic Publication: 2019 Nov 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Design*
Amyloid Precursor Protein Secretases/*chemistry
Aspartic Acid Endopeptidases/*chemistry
Molecular Docking Simulation/*methods
Amyloid Precursor Protein Secretases/antagonists & inhibitors ; Aspartic Acid Endopeptidases/antagonists & inhibitors ; Binding Sites/drug effects ; Humans ; Ligands ; Protein Binding/drug effects ; Surface Properties
Czasopismo naukowe
Tytuł :
D3R Grand Challenge 4: prospective pose prediction of BACE1 ligands with AutoDock-GPU.
Autorzy :
Santos-Martins D; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, USA.
Eberhardt J; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, USA.
Bianco G; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, USA.
Solis-Vasquez L; Embedded Systems and Applications Group, Technische Universität Darmstadt, Darmstadt, Germany.
Ambrosio FA; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, USA.; Department of Health Sciences, 'Magna Græcia' University of Catanzaro, Campus 'S. Venuta', Viale Europa, 88100, Catanzaro, Italy.
Koch A; Embedded Systems and Applications Group, Technische Universität Darmstadt, Darmstadt, Germany.
Forli S; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, USA. .
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Źródło :
Journal of computer-aided molecular design [J Comput Aided Mol Des] 2019 Dec; Vol. 33 (12), pp. 1071-1081. Date of Electronic Publication: 2019 Nov 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Molecular Docking Simulation*
Protein Binding*
Protein Conformation*
Amyloid Precursor Protein Secretases/*chemistry
Aspartic Acid Endopeptidases/*chemistry
Amyloid Precursor Protein Secretases/ultrastructure ; Aspartic Acid Endopeptidases/ultrastructure ; Binding Sites/drug effects ; Computer-Aided Design ; Crystallography, X-Ray ; Databases, Protein ; Drug Design ; Ligands ; Macrocyclic Compounds/chemistry ; Thermodynamics
Czasopismo naukowe

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