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Wyszukujesz frazę ""Aspartic Acid Endopeptidases"" wg kryterium: Temat


Tytuł:
New Highly Selective BACE1 Inhibitors and Their Effects on Dendritic Spine Density In Vivo.
Autorzy:
Pratsch K; German Center for Neurodegenerative Diseases (DZNE), 81377 Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany.; Center for Neuropathology and Prion Research (ZNP), Faculty of Medicine, LMU Munich, 81377 Munich, Germany.
Unemura C; Laboratory for Drug Discovery and Disease Research, Shionogi & Co., Ltd., Shionogi Pharmaceutical Research Center, Osaka 561-0825, Japan.
Ito M; Laboratory for Drug Discovery and Disease Research, Shionogi & Co., Ltd., Shionogi Pharmaceutical Research Center, Osaka 561-0825, Japan.
Lichtenthaler SF; German Center for Neurodegenerative Diseases (DZNE), 81377 Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany.; Neuroproteomics, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, 81675 Munich, Germany.
Horiguchi N; Laboratory for Drug Discovery and Disease Research, Shionogi & Co., Ltd., Shionogi Pharmaceutical Research Center, Osaka 561-0825, Japan.
Herms J; German Center for Neurodegenerative Diseases (DZNE), 81377 Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany.; Center for Neuropathology and Prion Research (ZNP), Faculty of Medicine, LMU Munich, 81377 Munich, Germany.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jul 31; Vol. 24 (15). Date of Electronic Publication: 2023 Jul 31.
Typ publikacji:
Journal Article
MeSH Terms:
Aspartic Acid Endopeptidases*/metabolism
Alzheimer Disease*/drug therapy
Alzheimer Disease*/metabolism
Animals ; Mice ; Amyloid Precursor Protein Secretases/metabolism ; Dendritic Spines/metabolism ; Amyloid beta-Peptides/metabolism ; Nerve Tissue Proteins/metabolism
Czasopismo naukowe
Tytuł:
Targeting blood brain barrier-Remote ischemic conditioning alleviates cognitive impairment in female APP/PS1 rats.
Autorzy:
Ma Y; International Science & Technology Cooperation Base of Geriatric, School of Public Health of North China University of Science and Technology, Tangshan, Hebei, China.
Sun W; School of Basic Medical Science, North China University of Science and Technology, Tangshan, Hebei, China.
Bai J; School of Basic Medical Science, North China University of Science and Technology, Tangshan, Hebei, China.
Gao F; International Science & Technology Cooperation Base of Geriatric, School of Public Health of North China University of Science and Technology, Tangshan, Hebei, China.
Ma H; International Science & Technology Cooperation Base of Geriatric, School of Public Health of North China University of Science and Technology, Tangshan, Hebei, China.
Liu H; International Science & Technology Cooperation Base of Geriatric, School of Public Health of North China University of Science and Technology, Tangshan, Hebei, China.
Hu J; School of Basic Medical Science, North China University of Science and Technology, Tangshan, Hebei, China.
Xu C; International Science & Technology Cooperation Base of Geriatric, School of Public Health of North China University of Science and Technology, Tangshan, Hebei, China.
Zhang X; International Science & Technology Cooperation Base of Geriatric, School of Public Health of North China University of Science and Technology, Tangshan, Hebei, China.
Liu Z; School of Basic Medical Science, North China University of Science and Technology, Tangshan, Hebei, China.
Yuan T; International Science & Technology Cooperation Base of Geriatric, School of Public Health of North China University of Science and Technology, Tangshan, Hebei, China.
Sun C; School of Basic Medical Science, North China University of Science and Technology, Tangshan, Hebei, China.
Huang Y; School of Basic Medical Science, North China University of Science and Technology, Tangshan, Hebei, China.
Wang R; International Science & Technology Cooperation Base of Geriatric, School of Public Health of North China University of Science and Technology, Tangshan, Hebei, China.; School of Basic Medical Science, North China University of Science and Technology, Tangshan, Hebei, China.
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Źródło:
CNS neuroscience & therapeutics [CNS Neurosci Ther] 2024 Feb; Vol. 30 (2), pp. e14613.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/drug therapy
Cognitive Dysfunction*/diagnostic imaging
Cognitive Dysfunction*/therapy
Mice ; Rats ; Female ; Animals ; Blood-Brain Barrier/metabolism ; Amyloid beta-Peptides/metabolism ; Amyloid beta-Protein Precursor/genetics ; Amyloid beta-Protein Precursor/metabolism ; Amyloid Precursor Protein Secretases/genetics ; Mice, Transgenic ; Rats, Transgenic ; Aspartic Acid Endopeptidases/genetics ; Aspartic Acid Endopeptidases/metabolism ; Aspartic Acid Endopeptidases/therapeutic use ; Disease Models, Animal ; Presenilin-1/genetics ; Presenilin-1/metabolism
Czasopismo naukowe
Tytuł:
Histone deacetylase inhibitors VPA and WT161 ameliorate the pathological features and cognitive impairments of the APP/PS1 Alzheimer's disease mouse model by regulating the expression of APP secretases.
Autorzy:
Zhang M; Department of Genetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.; Prenatal Diagnostic Center, Yiwu Maternity and Children Hospital, Yiwu, 322000, China.
Wang W; Department of Genetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.
Ye Q; Department of Genetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.
Fu Y; Department of Genetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.; College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Maternity and Child Health Hospital, Fujian Medical University, Fuzhou, 350000, China.
Li X; Department of Genetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.
Yang K; Department of Genetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.
Gao F; Department of Genetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.
Zhou A; Department of Genetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.
Wei Y; Department of Genetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.
Tian S; Department of Genetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.
Li S; Laboratory of Biological Psychiatry, Institute of Mental Health, Tianjin Anding Hospital, Mental Health Center of Tianjin Medical University, Tianjin, 300222, China.
Wei F; Department of Genetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.
Shi W; Department of Genetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China. .
Li WD; Department of Genetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China. .
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Źródło:
Alzheimer's research & therapy [Alzheimers Res Ther] 2024 Jan 20; Vol. 16 (1), pp. 15. Date of Electronic Publication: 2024 Jan 20.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Alzheimer Disease*/genetics
Cognitive Dysfunction*
Hydroxamic Acids*
Terphenyl Compounds*
Mice ; Animals ; Histone Deacetylase Inhibitors/pharmacology ; Histone Deacetylase Inhibitors/therapeutic use ; Amyloid Precursor Protein Secretases/metabolism ; Amyloid beta-Peptides/metabolism ; Chromatography, Liquid ; Aspartic Acid Endopeptidases/metabolism ; Tandem Mass Spectrometry ; Mice, Transgenic ; Disease Models, Animal ; Amyloid beta-Protein Precursor/genetics ; Amyloid beta-Protein Precursor/metabolism ; Presenilin-1/genetics ; Presenilin-1/metabolism
Czasopismo naukowe
Tytuł:
Response to Zhang et al., 'do egg cell-secreted aspartic proteases promote gamete attachment?'
Autorzy:
Jiang J; State Key Laboratory for Protein and Plant Gene Research, Peking-Tsinghua Center for Life Sciences at College of Life Sciences, Peking University, Beijing, 100871, China.
Qu LJ; State Key Laboratory for Protein and Plant Gene Research, Peking-Tsinghua Center for Life Sciences at College of Life Sciences, Peking University, Beijing, 100871, China.
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Źródło:
Journal of integrative plant biology [J Integr Plant Biol] 2023 Jan; Vol. 65 (1), pp. 7-9.
Typ publikacji:
Journal Article; Comment
MeSH Terms:
Aspartic Acid Endopeptidases*
Germ Cells*
Czasopismo naukowe
Tytuł:
Do egg cell-secreted aspartic proteases promote gamete attachment?
Autorzy:
Zhang X; State Key Laboratory of Hybrid Rice, College of Life Sciences, Wuhan University, Wuhan, 430072, China.
Yu X; Bamboo Diseases and Pest Control and Resources Development Key Laboratory of Sichuan Province, College of Life Science, Leshan Normal University, Leshan, 614000, China.
Shi C; State Key Laboratory of Hybrid Rice, College of Life Sciences, Wuhan University, Wuhan, 430072, China.
Dresselhaus T; Cell Biology and Plant Biochemistry, University of Regensburg, Regensburg, 31 93053, Germany.
Sun MX; State Key Laboratory of Hybrid Rice, College of Life Sciences, Wuhan University, Wuhan, 430072, China.
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Źródło:
Journal of integrative plant biology [J Integr Plant Biol] 2023 Jan; Vol. 65 (1), pp. 3-6.
Typ publikacji:
Journal Article
MeSH Terms:
Aspartic Acid Endopeptidases*/metabolism
Germ Cells*/metabolism
Biological Transport
Czasopismo naukowe
Tytuł:
PS1 Affects the Pathology of Alzheimer's Disease by Regulating BACE1 Distribution in the ER and BACE1 Maturation in the Golgi Apparatus.
Autorzy:
Li N; School of Medical Technology, Beijing Institute of Technology, Beijing 100081, China.; Key Laboratory of Molecular Medicine and Biotherapy, Department of Biology, School of Life Science, Beijing Institute of Technology, Beijing 100081, China.
Qiu Y; Key Laboratory of Molecular Medicine and Biotherapy, Department of Biology, School of Life Science, Beijing Institute of Technology, Beijing 100081, China.
Wang H; School of Medical Technology, Beijing Institute of Technology, Beijing 100081, China.
Zhao J; Key Laboratory of Molecular Medicine and Biotherapy, Department of Biology, School of Life Science, Beijing Institute of Technology, Beijing 100081, China.
Qing H; Key Laboratory of Molecular Medicine and Biotherapy, Department of Biology, School of Life Science, Beijing Institute of Technology, Beijing 100081, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Dec 18; Vol. 23 (24). Date of Electronic Publication: 2022 Dec 18.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/metabolism
Amyloid Precursor Protein Secretases*/genetics
Amyloid Precursor Protein Secretases*/metabolism
Aspartic Acid Endopeptidases*/genetics
Aspartic Acid Endopeptidases*/metabolism
Presenilin-1*/metabolism
Animals ; Mice ; Amyloid beta-Peptides/metabolism ; Amyloid beta-Protein Precursor/genetics ; Amyloid beta-Protein Precursor/metabolism ; Golgi Apparatus/metabolism ; Mutation
Czasopismo naukowe
Tytuł:
Next Generation Therapeutic Strategy for Treatment and Prevention of Alzheimer's Disease and Aging-Associated Cognitive Decline: Transient, Once-in-a-Lifetime-Only Depletion of Intraneuronal Aβ ( i Aβ) by Its Targeted Degradation via Augmentation of Intra- i Aβ-Cleaving Activities of BACE1 and/or BACE2.
Autorzy:
Volloch V; Department of Developmental Biology, Harvard School of Dental Medicine, Boston, MA 02115, USA.
Rits-Volloch S; Division of Molecular Medicine, Children's Hospital, Boston, MA 02115, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Dec 18; Vol. 24 (24). Date of Electronic Publication: 2023 Dec 18.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/metabolism
Cognitive Dysfunction*/drug therapy
Cognitive Dysfunction*/prevention & control
Humans ; Amyloid Precursor Protein Secretases/genetics ; Amyloid Precursor Protein Secretases/metabolism ; Aspartic Acid Endopeptidases/genetics ; Aspartic Acid Endopeptidases/metabolism ; Amyloid beta-Peptides/metabolism ; Amyloid beta-Protein Precursor/metabolism ; Aging
Czasopismo naukowe
Tytuł:
Helical stability of the GnTV transmembrane domain impacts on SPPL3 dependent cleavage.
Autorzy:
Papadopoulou AA; Biochemistry and Molecular Biology, Institute of Theoretical Medicine, Faculty of Medicine, University of Augsburg, Universitätstrasse 2, 86159, Augsburg, Germany.
Stelzer W; Lehrstuhl für Chemie der Biopolymere, Technische Universität München, Weihenstephaner Berg 3, 85354, Freising, Germany.
Silber M; Institute for Biological Interfaces 4, Karlsruhe Institute of Technology, 76344, Eggenstein-Leopoldshafen, Germany.; Institute of Organic Chemistry, Karlsruhe Institute of Technology, 76131, Karlsruhe, Germany.
Schlosser C; Biochemistry and Molecular Biology, Institute of Theoretical Medicine, Faculty of Medicine, University of Augsburg, Universitätstrasse 2, 86159, Augsburg, Germany.
Spitz C; Biochemistry and Molecular Biology, Institute of Theoretical Medicine, Faculty of Medicine, University of Augsburg, Universitätstrasse 2, 86159, Augsburg, Germany.
Haug-Kröper M; Biochemistry and Molecular Biology, Institute of Theoretical Medicine, Faculty of Medicine, University of Augsburg, Universitätstrasse 2, 86159, Augsburg, Germany.
Straub T; Core Facility Bioinformatics, Biomedical Center, Ludwig Maximilians University Munich, 82152, Planegg-Martinsried, Germany.
Müller SA; DZNE - German Center for Neurodegenerative Diseases, Munich, Germany.
Lichtenthaler SF; DZNE - German Center for Neurodegenerative Diseases, Munich, Germany.; Neuroproteomics, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, 81675, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
Muhle-Goll C; Institute for Biological Interfaces 4, Karlsruhe Institute of Technology, 76344, Eggenstein-Leopoldshafen, Germany.; Institute of Organic Chemistry, Karlsruhe Institute of Technology, 76131, Karlsruhe, Germany.
Langosch D; Lehrstuhl für Chemie der Biopolymere, Technische Universität München, Weihenstephaner Berg 3, 85354, Freising, Germany.
Fluhrer R; Biochemistry and Molecular Biology, Institute of Theoretical Medicine, Faculty of Medicine, University of Augsburg, Universitätstrasse 2, 86159, Augsburg, Germany. .
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Źródło:
Scientific reports [Sci Rep] 2022 Dec 05; Vol. 12 (1), pp. 20987. Date of Electronic Publication: 2022 Dec 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Aspartic Acid Endopeptidases*/metabolism
Membrane Proteins*/genetics
Membrane Proteins*/metabolism
Golgi Apparatus/metabolism ; Glycosylation ; Polysaccharides/metabolism
Czasopismo naukowe
Tytuł:
VHHs as tools for therapeutic protein delivery to the central nervous system.
Autorzy:
Wouters Y; VIB Center for Brain and Disease Research, Campus Gasthuisberg O&N4, Herestraat 49, box 602, 3000, Louvain, Belgium.; Laboratory for the Research of Neurodegenerative Diseases, Department of Neurosciences, Leuven Brain Institute (LBI), KU Leuven, 3000, Louvain, Belgium.; Department of Biotechnology and Biomedicine, Technical University of Denmark, 2800, Kongens Lyngby, Denmark.
Jaspers T; VIB Center for Brain and Disease Research, Campus Gasthuisberg O&N4, Herestraat 49, box 602, 3000, Louvain, Belgium.; Laboratory for the Research of Neurodegenerative Diseases, Department of Neurosciences, Leuven Brain Institute (LBI), KU Leuven, 3000, Louvain, Belgium.; Laboratory for Therapeutic and Diagnostic Antibodies, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 3000, Louvain, Belgium.
Rué L; VIB Center for Brain and Disease Research, Campus Gasthuisberg O&N4, Herestraat 49, box 602, 3000, Louvain, Belgium.; Laboratory for the Research of Neurodegenerative Diseases, Department of Neurosciences, Leuven Brain Institute (LBI), KU Leuven, 3000, Louvain, Belgium.
Serneels L; VIB Center for Brain and Disease Research, Campus Gasthuisberg O&N4, Herestraat 49, box 602, 3000, Louvain, Belgium.; Laboratory for the Research of Neurodegenerative Diseases, Department of Neurosciences, Leuven Brain Institute (LBI), KU Leuven, 3000, Louvain, Belgium.
De Strooper B; VIB Center for Brain and Disease Research, Campus Gasthuisberg O&N4, Herestraat 49, box 602, 3000, Louvain, Belgium. .; Laboratory for the Research of Neurodegenerative Diseases, Department of Neurosciences, Leuven Brain Institute (LBI), KU Leuven, 3000, Louvain, Belgium. .; UK Dementia Research Institute, University College London, London, UK. .
Dewilde M; VIB Center for Brain and Disease Research, Campus Gasthuisberg O&N4, Herestraat 49, box 602, 3000, Louvain, Belgium. .; Laboratory for the Research of Neurodegenerative Diseases, Department of Neurosciences, Leuven Brain Institute (LBI), KU Leuven, 3000, Louvain, Belgium. .; Laboratory for Therapeutic and Diagnostic Antibodies, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 3000, Louvain, Belgium. .
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Źródło:
Fluids and barriers of the CNS [Fluids Barriers CNS] 2022 Oct 03; Vol. 19 (1), pp. 79. Date of Electronic Publication: 2022 Oct 03.
Typ publikacji:
Journal Article
MeSH Terms:
Amyloid Precursor Protein Secretases*
Aspartic Acid Endopeptidases*/metabolism
Animals ; Antibodies/metabolism ; Blood-Brain Barrier/metabolism ; Humans ; Mice ; Neurotensin ; Receptors, Transferrin ; Transferrin/metabolism
Czasopismo naukowe
Tytuł:
Computer-Aided Prediction of the Interactions of Viral Proteases with Antiviral Drugs: Antiviral Potential of Broad-Spectrum Drugs.
Autorzy:
Ren P; School of Life Science and Technology, Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai 201210, China.
Li S; School of Life Science and Technology, Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai 201210, China.
Wang S; School of Life Science and Technology, Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai 201210, China.
Zhang X; School of Life Science and Technology, Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai 201210, China.
Bai F; School of Life Science and Technology, Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai 201210, China.; School of Information Science and Technology, ShanghaiTech University, Shanghai 201210, China.; Shanghai Clinical Research and Trial Center, Shanghai 201210, China.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2023 Dec 31; Vol. 29 (1). Date of Electronic Publication: 2023 Dec 31.
Typ publikacji:
Journal Article
MeSH Terms:
Viral Proteases*
Peptide Hydrolases*
Humans ; Aspartic Acid Endopeptidases ; Computers ; Protease Inhibitors/pharmacology ; Antiviral Agents/pharmacology
Czasopismo naukowe
Tytuł:
Amyloidogenic and Neuroinflammatory Molecular Pathways Are Contrasted Using Menaquinone 4 (MK4) and Reduced Menaquinone 7 (MK7R) in Association with Increased DNA Methylation in SK-N-BE Neuroblastoma Cell Line.
Autorzy:
Orticello M; Department of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy.
Cavallaro RA; Department of Surgery, Sapienza University of Rome, 00161 Rome, Italy.
Antinori D; Department of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy.
Raia T; Department of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy.
Lucarelli M; Department of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy.; Pasteur Institute, Cenci Bolognetti Foundation, Sapienza University of Rome, 00161 Rome, Italy.
Fuso A; Department of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy.
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Źródło:
Cells [Cells] 2023 Dec 27; Vol. 13 (1). Date of Electronic Publication: 2023 Dec 27.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Neurodegenerative Diseases*
Neuroblastoma*/genetics
Animals ; Humans ; Vitamin K 2/pharmacology ; Neuroinflammatory Diseases ; Amyloid Precursor Protein Secretases ; DNA Methylation/genetics ; Epigenesis, Genetic ; Interleukin-6 ; Aspartic Acid Endopeptidases ; Vitamin K ; Cell Line
Czasopismo naukowe
Tytuł:
Total alkaloids from the seed embryo of Nelumbo nucifera Gaertn. improve cognitive impairment in APP/PS1 mice and protect Aβ-damaged PC12 cells.
Autorzy:
Meng XL; School of Pharmaceutical Science, Liaoning University, Shenyang, People's Republic of China.; Research Center for Natural Product Pharmacy of Liaoning Province, Shenyang, People's Republic of China.
Xue JS; School of Pharmaceutical Science, Liaoning University, Shenyang, People's Republic of China.
Su SJ; School of Pharmaceutical Science, Liaoning University, Shenyang, People's Republic of China.
Gou JM; School of Pharmaceutical Science, Liaoning University, Shenyang, People's Republic of China.
Lu J; School of Pharmaceutical Science, Liaoning University, Shenyang, People's Republic of China.; Research Center for Natural Product Pharmacy of Liaoning Province, Shenyang, People's Republic of China.
Chen CL; School of Pharmaceutical Science, Liaoning University, Shenyang, People's Republic of China.
Xu CB; School of Environmental Science, Liaoning University, Shenyang, People's Republic of China.
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Źródło:
Nutritional neuroscience [Nutr Neurosci] 2023 Dec; Vol. 26 (12), pp. 1243-1257. Date of Electronic Publication: 2022 Nov 12.
Typ publikacji:
Journal Article
MeSH Terms:
Nelumbo*/metabolism
Alzheimer Disease*/metabolism
Alkaloids*/therapeutic use
Cognitive Dysfunction*
Mice ; Animals ; Rats ; Amyloid Precursor Protein Secretases/metabolism ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/therapeutic use ; PC12 Cells ; Aspartic Acid Endopeptidases/therapeutic use ; Amyloid beta-Peptides/metabolism ; Mice, Transgenic ; Disease Models, Animal ; Amyloid beta-Protein Precursor/genetics
Czasopismo naukowe
Tytuł:
m6A modified BACE1-AS contributes to liver metastasis and stemness-like properties in colorectal cancer through TUFT1 dependent activation of Wnt signaling.
Autorzy:
Wang X; Central Laboratory of the Medical Research Center, The First Affiliated Hospital of Ningbo University, 247 Renmin Road, Jiangbei District, Ningbo, 315020, P. R. China. .; Health Science Center, Ningbo University, 818 Fenghua Road, Jiangbei District, Ningbo, 315211, P. R. China. .
Liu Y; Health Science Center, Ningbo University, 818 Fenghua Road, Jiangbei District, Ningbo, 315211, P. R. China.
Zhou M; Central Laboratory of the Medical Research Center, The First Affiliated Hospital of Ningbo University, 247 Renmin Road, Jiangbei District, Ningbo, 315020, P. R. China.
Yu L; Department of Colorectal Cancer Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, P. R. China.
Si Z; Health Science Center, Ningbo University, 818 Fenghua Road, Jiangbei District, Ningbo, 315211, P. R. China. .
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Źródło:
Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2023 Nov 21; Vol. 42 (1), pp. 306. Date of Electronic Publication: 2023 Nov 21.
Typ publikacji:
Journal Article
MeSH Terms:
Colorectal Neoplasms*/metabolism
Colorectal Neoplasms*/pathology
RNA, Antisense*/metabolism
Amyloid Precursor Protein Secretases*/genetics
Liver Neoplasms*/secondary
Dental Enamel Proteins*/metabolism
Wnt Signaling Pathway ; Aspartic Acid Endopeptidases/genetics ; Cell Line, Tumor ; Adenosine/analogs & derivatives ; Humans ; RNA-Binding Proteins/metabolism
Czasopismo naukowe
Tytuł:
Potential Implications of miRNAs in the Pathogenesis, Diagnosis, and Therapeutics of Alzheimer's Disease.
Autorzy:
Wang L; Fujian Key Laboratory of Translational Research in Cancer and Neurodegenerative Diseases, School of Basic Medical Sciences, Fujian Medical University, Fuzhou 350122, China.
Shui X; Fujian Key Laboratory of Translational Research in Cancer and Neurodegenerative Diseases, School of Basic Medical Sciences, Fujian Medical University, Fuzhou 350122, China.
Diao Y; Fujian Key Laboratory of Translational Research in Cancer and Neurodegenerative Diseases, School of Basic Medical Sciences, Fujian Medical University, Fuzhou 350122, China.
Chen D; Fujian Key Laboratory of Translational Research in Cancer and Neurodegenerative Diseases, School of Basic Medical Sciences, Fujian Medical University, Fuzhou 350122, China.
Zhou Y; Fujian Key Laboratory of Translational Research in Cancer and Neurodegenerative Diseases, School of Basic Medical Sciences, Fujian Medical University, Fuzhou 350122, China.
Lee TH; Fujian Key Laboratory of Translational Research in Cancer and Neurodegenerative Diseases, School of Basic Medical Sciences, Fujian Medical University, Fuzhou 350122, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Nov 13; Vol. 24 (22). Date of Electronic Publication: 2023 Nov 13.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Alzheimer Disease*/diagnosis
Alzheimer Disease*/genetics
Alzheimer Disease*/therapy
MicroRNAs*/genetics
MicroRNAs*/metabolism
Humans ; Aged ; Amyloid Precursor Protein Secretases/metabolism ; Aspartic Acid Endopeptidases/metabolism ; Amyloid beta-Protein Precursor/genetics ; Amyloid beta-Protein Precursor/metabolism ; tau Proteins/genetics ; tau Proteins/metabolism ; Phosphorylation ; Amyloid beta-Peptides/metabolism
Czasopismo naukowe
Tytuł:
New Benzamides as Multi-Targeted Compounds: A Study on Synthesis, AChE and BACE1 Inhibitory Activity and Molecular Docking.
Autorzy:
Drozdowska D; Department of Organic Chemistry, Medical University of Białystok, Mickiewicza Street 2A, 15-222 Białystok, Poland.
Maliszewski D; Department of Organic Chemistry, Medical University of Białystok, Mickiewicza Street 2A, 15-222 Białystok, Poland.
Wróbel A; Department of Organic Chemistry, Medical University of Białystok, Mickiewicza Street 2A, 15-222 Białystok, Poland.
Ratkiewicz A; Department of Physical Chemistry, Faculty of Chemistry, University of Białystok, Ciołkowskiego 1K Street, 15-245 Białystok, Poland.
Sienkiewicz M; Department of Physical Chemistry, Faculty of Chemistry, University of Białystok, Ciołkowskiego 1K Street, 15-245 Białystok, Poland.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Oct 04; Vol. 24 (19). Date of Electronic Publication: 2023 Oct 04.
Typ publikacji:
Journal Article
MeSH Terms:
Acetylcholinesterase*/metabolism
Alzheimer Disease*/drug therapy
Humans ; Molecular Docking Simulation ; Cholinesterase Inhibitors/pharmacology ; Amyloid Precursor Protein Secretases/metabolism ; Aspartic Acid Endopeptidases/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł:
Absolute binding free energy calculations improve enrichment of actives in virtual compound screening.
Autorzy:
Feng M; Department of Chemistry and Biochemistry, and Skaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego, La Jolla, CA, 92093, USA.
Heinzelmann G; Departamento de Física, Universidade Federal de Santa Catarina, Florianópolis, Santa Catarina, Brazil.
Gilson MK; Department of Chemistry and Biochemistry, and Skaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego, La Jolla, CA, 92093, USA. .
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Źródło:
Scientific reports [Sci Rep] 2022 Aug 10; Vol. 12 (1), pp. 13640. Date of Electronic Publication: 2022 Aug 10.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Amyloid Precursor Protein Secretases*
Aspartic Acid Endopeptidases*
Entropy ; Ligands ; Molecular Docking Simulation ; Protein Binding
Czasopismo naukowe
Tytuł:
Stem cells-derived exosomes alleviate neurodegeneration and Alzheimer's pathogenesis by ameliorating neuroinflamation, and regulating the associated molecular pathways.
Autorzy:
Khan MI; Department of Biotechnology, Faculty of Biomedical and Life Sciences, Kohsar University, Murree, Pakistan.
Jeong ES; Department of Laboratory Medicine, Yeosu Chonnam Hospital, Yeosu, Korea.
Khan MZ; Department of Biotechnology, Chonnam Notational University, San96-1, Dun-Duk Dong, Yeosu, 59626, Chonnam, Korea.
Shin JH; Department of Biotechnology, Chonnam Notational University, San96-1, Dun-Duk Dong, Yeosu, 59626, Chonnam, Korea.
Kim JD; Department of Biotechnology, Chonnam Notational University, San96-1, Dun-Duk Dong, Yeosu, 59626, Chonnam, Korea. .; Research Center on Anti-Obesity and Health Care, Chonnam National University, San96-1, Dun-Duk Dong, Yeosu, 59626, Chonnam, Korea. .
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Źródło:
Scientific reports [Sci Rep] 2023 Sep 21; Vol. 13 (1), pp. 15731. Date of Electronic Publication: 2023 Sep 21.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Alzheimer Disease*/therapy
Exosomes*
Neuroblastoma*/therapy
Neural Stem Cells*
Humans ; Amyloid Precursor Protein Secretases/genetics ; Glycogen Synthase Kinase 3 beta ; Acetylcholinesterase ; Amyloid beta-Peptides ; Aspartic Acid Endopeptidases/genetics
Czasopismo naukowe
Tytuł:
Genome-wide association study of abnormal elevation of ALT in patients exposed to atabecestat.
Autorzy:
Li QS; Neuroscience, Janssen Research & Development, LLC, Titusville, NJ, 08560, USA. .; JRD Data Science, Janssen Research & Development, LLC, Titusville, NJ, 08560, USA. .
Francke S; Computational Science Translational Platforms, Janssen Research & Development, LLC, Spring House, PA, 19477, USA.; Pharmacogenomics & Biomarker in Clinical Development, Cary, NC, USA.
Snoeys J; Translational Pharmacokinetics Pharmacodynamics and Investigative Toxicology, Janssen Research & Development, Beerse, Belgium.
Thipphawong J; Neuroscience, Janssen Research & Development, LLC, Titusville, NJ, 08560, USA.
Romano G; Neuroscience, Janssen Research & Development, LLC, Titusville, NJ, 08560, USA.; Passage Bio, Philadelphia, PA, USA.
Novak GP; Neuroscience, Janssen Research & Development, LLC, Titusville, NJ, 08560, USA.
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Źródło:
BMC genomics [BMC Genomics] 2023 Sep 01; Vol. 24 (1), pp. 513. Date of Electronic Publication: 2023 Sep 01.
Typ publikacji:
Journal Article
MeSH Terms:
Genome-Wide Association Study*
Amyloid Precursor Protein Secretases*/genetics
Humans ; Alanine Transaminase ; Amyloid beta-Peptides ; Aspartic Acid Endopeptidases ; Carrier Proteins ; Mitochondrial Proteins
Czasopismo naukowe
Tytuł:
Advances and applications of fluids biomarkers in diagnosis and therapeutic targets of Alzheimer's disease.
Autorzy:
Xu Y; Department of Pharmacy, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.; School of Pharmacy, Capital Medical University, Beijing, China.
Jiang H; Department of Pharmacy, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Zhu B; Department of Pharmacy, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Cao M; Department of Pharmacy, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Feng T; Center for Movement Disorders, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Sun Z; Department of Pharmacy, The Sixth Medical Center of PLA General Hospital, Beijing, China.
Du G; The State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing, China.; Key Laboratory of Drug Target Research and Drug Screen, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
Zhao Z; Department of Pharmacy, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.; School of Pharmacy, Capital Medical University, Beijing, China.
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Źródło:
CNS neuroscience & therapeutics [CNS Neurosci Ther] 2023 Aug; Vol. 29 (8), pp. 2060-2073. Date of Electronic Publication: 2023 May 05.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
Alzheimer Disease*/diagnosis
Alzheimer Disease*/drug therapy
Neurodegenerative Diseases*
Humans ; Amyloid Precursor Protein Secretases ; Aspartic Acid Endopeptidases ; tau Proteins/cerebrospinal fluid ; Amyloid beta-Peptides/cerebrospinal fluid ; Biomarkers/cerebrospinal fluid ; Peptide Fragments/cerebrospinal fluid
Czasopismo naukowe

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