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Tytuł:
Astrocytes display ultrastructural alterations and heterogeneity in the hippocampus of aged APP-PS1 mice and human post-mortem brain samples.
Autorzy:
St-Pierre MK; Axe Neurosciences, Centre de Recherche du CHU de Québec-Université Laval, Québec, QC, Canada.; Départment de Médecine Moléculaire, Faculté de Médecine, Université Laval, Québec, QC, Canada.; Division of Medical Sciences, Medical Sciences Building, University of Victoria, Victoria, BC, Canada.
Carrier M; Axe Neurosciences, Centre de Recherche du CHU de Québec-Université Laval, Québec, QC, Canada.; Division of Medical Sciences, Medical Sciences Building, University of Victoria, Victoria, BC, Canada.
González Ibáñez F; Axe Neurosciences, Centre de Recherche du CHU de Québec-Université Laval, Québec, QC, Canada.; Départment de Médecine Moléculaire, Faculté de Médecine, Université Laval, Québec, QC, Canada.; Division of Medical Sciences, Medical Sciences Building, University of Victoria, Victoria, BC, Canada.
Khakpour M; Division of Medical Sciences, Medical Sciences Building, University of Victoria, Victoria, BC, Canada.
Wallman MJ; Département de Psychiatrie et de Neurosciences, Faculté de Médecine, Université Laval, Québec, QC, Canada.; CERVO Brain Research Center, Quebec City, QC, Canada.
Parent M; Département de Psychiatrie et de Neurosciences, Faculté de Médecine, Université Laval, Québec, QC, Canada.; CERVO Brain Research Center, Quebec City, QC, Canada.
Tremblay MÈ; Axe Neurosciences, Centre de Recherche du CHU de Québec-Université Laval, Québec, QC, Canada. .; Départment de Médecine Moléculaire, Faculté de Médecine, Université Laval, Québec, QC, Canada. .; Division of Medical Sciences, Medical Sciences Building, University of Victoria, Victoria, BC, Canada. .; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada. .; Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada. .; Centre for Advanced Materials and Related Technology (CAMTEC), University of Victoria, Victoria, BC, Canada. .; Institute on Aging and Lifelong Health, University of Victoria, Victoria, BC, Canada. .
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Źródło:
Journal of neuroinflammation [J Neuroinflammation] 2023 Mar 14; Vol. 20 (1), pp. 73. Date of Electronic Publication: 2023 Mar 14.
Typ publikacji:
Journal Article
MeSH Terms:
Astrocytes*/metabolism
Alzheimer Disease*/pathology
Mice ; Humans ; Male ; Animals ; Aged ; Infant ; Mice, Inbred C57BL ; Brain/metabolism ; Hippocampus/metabolism ; Mice, Transgenic ; Disease Models, Animal ; Amyloid beta-Protein Precursor/genetics ; Amyloid beta-Protein Precursor/metabolism ; Presenilin-1/genetics ; Presenilin-1/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Roles of neuropathology-associated reactive astrocytes: a systematic review.
Autorzy:
Lawrence JM; Molecular and Cell Biology and Genetics Graduate Program, Drexel University College of Medicine, Philadelphia, PA, USA.; Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, USA.; Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA, USA.
Schardien K; Molecular and Cell Biology and Genetics Graduate Program, Drexel University College of Medicine, Philadelphia, PA, USA.; Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA, USA.
Wigdahl B; Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, USA.; Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA, USA.; Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA.
Nonnemacher MR; Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, USA. .; Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA, USA. .; Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA. .
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Źródło:
Acta neuropathologica communications [Acta Neuropathol Commun] 2023 Mar 13; Vol. 11 (1), pp. 42. Date of Electronic Publication: 2023 Mar 13.
Typ publikacji:
Systematic Review; Journal Article; Review
MeSH Terms:
Astrocytes*/metabolism
Neurotoxicity Syndromes*/pathology
Humans ; Microglia/metabolism ; Central Nervous System/metabolism ; Blood-Brain Barrier/metabolism ; Chemokines/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Inhibition of A1 Astrocytes and Activation of A2 Astrocytes for the Treatment of Spinal Cord Injury.
Autorzy:
Wang J; Key Laboratory of Medical Electrophysiology, Ministry of Education, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, China.
Cheng C; Key Laboratory of Medical Electrophysiology, Ministry of Education, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, China.
Liu Z; Key Laboratory of Medical Electrophysiology, Ministry of Education, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, China.
Lin Y; Key Laboratory of Medical Electrophysiology, Ministry of Education, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, China.
Yang L; Key Laboratory of Medical Electrophysiology, Ministry of Education, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, China.
Zhang Z; Key Laboratory of Medical Electrophysiology, Ministry of Education, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, China.
Sun X; Key Laboratory of Medical Electrophysiology, Ministry of Education, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, China.
Zhou M; Department of Pharmacy, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, Sichuan, China.
Jing P; Department of Pharmacy, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, Sichuan, China. .
Zhong Z; Key Laboratory of Medical Electrophysiology, Ministry of Education, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, China. .; Central Nervous System Drug Key Laboratory of Sichuan Province, Luzhou, 646000, Sichuan, China. .
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Źródło:
Neurochemical research [Neurochem Res] 2023 Mar; Vol. 48 (3), pp. 767-780. Date of Electronic Publication: 2022 Nov 23.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Astrocytes*/pathology
Spinal Cord Injuries*/drug therapy
Spinal Cord Injuries*/pathology
Humans ; Neurons/pathology ; Gliosis/pathology ; Central Nervous System ; Spinal Cord/pathology
Czasopismo naukowe
Szczegóły
Tytuł:
Astrocyte reactivity in the glia limitans superficialis of the rat medial prefrontal cortex following sciatic nerve injury.
Autorzy:
Bretová K; Department of Anatomy, Cellular and Molecular Research Group, Faculty of Medicine, Masaryk University, Kamenice 3, Brno, 62500, Czech Republic.
Svobodová V; Department of Anatomy, Cellular and Molecular Research Group, Faculty of Medicine, Masaryk University, Kamenice 3, Brno, 62500, Czech Republic.
Dubový P; Department of Anatomy, Cellular and Molecular Research Group, Faculty of Medicine, Masaryk University, Kamenice 3, Brno, 62500, Czech Republic. .
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Źródło:
Histochemistry and cell biology [Histochem Cell Biol] 2023 Feb; Vol. 159 (2), pp. 185-198. Date of Electronic Publication: 2022 Nov 03.
Typ publikacji:
Journal Article
MeSH Terms:
Astrocytes*/metabolism
Astrocytes*/pathology
Peripheral Nerve Injuries*/metabolism
Rats ; Animals ; Prefrontal Cortex/metabolism ; Sciatic Nerve/injuries ; Sciatic Nerve/metabolism ; Glial Fibrillary Acidic Protein/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Small-molecule screen reveals pathways that regulate C4 secretion in stem cell-derived astrocytes.
Autorzy:
Rapino F; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address: francesca_.
Natoli T; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Limone F; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Leiden University Medical Center, LUMC, 2333 ZA Leiden, the Netherlands.
O'Connor E; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.
Blank J; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.
Tegtmeyer M; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Chen W; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.
Norabuena E; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.
Narula J; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.
Hazelbaker D; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Angelini G; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Barrett L; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
O'Neil A; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.
Beattie UK; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.
Thanos JM; Center for Quantitative Health, Center for Genomic Medicine and Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
de Rivera H; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Genetics, Harvard Medical School, Boston, MA, USA.
Sheridan SD; Center for Quantitative Health, Center for Genomic Medicine and Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
Perlis RH; Center for Quantitative Health, Center for Genomic Medicine and Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
McCarroll SA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Genetics, Harvard Medical School, Boston, MA, USA.
Stevens B; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Neurology, F.M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Subramanian A; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Nehme R; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Rubin LL; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address: lee_.
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Źródło:
Stem cell reports [Stem Cell Reports] 2023 Jan 10; Vol. 18 (1), pp. 237-253. Date of Electronic Publication: 2022 Dec 22.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms:
Astrocytes*/metabolism
Induced Pluripotent Stem Cells*/metabolism
Stem Cells ; Fetus
Czasopismo naukowe
Szczegóły
Tytuł:
Digoxin Induces Human Astrocyte Reaction In Vitro.
Autorzy:
Pamies D; Department of Biological Sciences, University of Lausanne, Lausanne, Switzerland.; School of Pharmaceutical Sciences and Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Geneva, Switzerland.
Vujić T; Swiss Centre for Applied Human Toxicology (SCAHT), Basel, Switzerland.; School of Pharmaceutical Sciences and Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Geneva, Switzerland.
Schvartz D; Swiss Centre for Applied Human Toxicology (SCAHT), Basel, Switzerland.; School of Pharmaceutical Sciences and Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Geneva, Switzerland.
Boccard J; Translational Biomarker Group, Department of Medicine, University of Geneva, Geneva, Switzerland.; School of Pharmaceutical Sciences and Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Geneva, Switzerland.
Repond C; Department of Biological Sciences, University of Lausanne, Lausanne, Switzerland.
Nunes C; Department of Biological Sciences, University of Lausanne, Lausanne, Switzerland.; School of Pharmaceutical Sciences and Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Geneva, Switzerland.
Rudaz S; Translational Biomarker Group, Department of Medicine, University of Geneva, Geneva, Switzerland.; School of Pharmaceutical Sciences and Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Geneva, Switzerland.
Sanchez JC; Swiss Centre for Applied Human Toxicology (SCAHT), Basel, Switzerland.; School of Pharmaceutical Sciences and Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Geneva, Switzerland.
González-Ruiz V; Translational Biomarker Group, Department of Medicine, University of Geneva, Geneva, Switzerland.; School of Pharmaceutical Sciences and Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Geneva, Switzerland.
Zurich MG; Department of Biological Sciences, University of Lausanne, Lausanne, Switzerland. .; School of Pharmaceutical Sciences and Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Geneva, Switzerland. .
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Źródło:
Molecular neurobiology [Mol Neurobiol] 2023 Jan; Vol. 60 (1), pp. 84-97. Date of Electronic Publication: 2022 Oct 12.
Typ publikacji:
Journal Article
MeSH Terms:
Astrocytes*/drug effects
Astrocytes*/metabolism
Digoxin*/pharmacology
Humans ; Central Nervous System/metabolism ; Energy Metabolism ; Tumor Necrosis Factor-alpha/pharmacology ; Cells, Cultured
Czasopismo naukowe
Szczegóły
Tytuł:
Specific knockout of Sox2 in astrocytes reduces reactive astrocyte formation and promotes recovery after early postnatal traumatic brain injury in mouse cortex.
Autorzy:
Liu Y; Department of Anatomy, Histology and Embryology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Hong W; Department of Anatomy, Histology and Embryology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Gong P; Department of Anatomy, Histology and Embryology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Qi G; Department of Anatomy, Histology and Embryology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Wang X; Department of Anatomy, Histology and Embryology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Kang S; Department of Anatomy, Histology and Embryology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Tang H; Department of Anatomy, Histology and Embryology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Qin S; Department of Anatomy, Histology and Embryology, School of Basic Medical Sciences, Fudan University, Shanghai, China.; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China.
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Źródło:
Glia [Glia] 2023 Mar; Vol. 71 (3), pp. 602-615. Date of Electronic Publication: 2022 Nov 10.
Typ publikacji:
Journal Article
MeSH Terms:
Astrocytes*/metabolism
Brain Injuries, Traumatic*/pathology
SOXB1 Transcription Factors*/genetics
Animals ; Mice ; Central Nervous System/metabolism ; Gliosis/pathology ; Neuroglia/metabolism ; Mice, Knockout
Czasopismo naukowe
Szczegóły
Tytuł:
Contribution of inwardly rectifying K channel 4.1 of supraoptic astrocytes to the regulation of vasopressin neuronal activity by hypotonicity.
Autorzy:
Jiang YH; Department of Physiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Li T; Department of Physiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.; Neuroelectrophysiology Laboratory, School of Mental Health, Qiqihar Medical University, Qiqihar, China.
Liu Y; Department of Physiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Liu X; Department of Physiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Jia S; Department of Physiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Hou C; Department of Physiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Chen G; Department of Physiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Wang H; Department of Physiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Ling S; Department of Physiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Gao Q; Department of Physiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Wang XR; Department of Physiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Wang YF; Department of Physiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
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Źródło:
Glia [Glia] 2023 Mar; Vol. 71 (3), pp. 704-719. Date of Electronic Publication: 2022 Nov 21.
Typ publikacji:
Journal Article
MeSH Terms:
Astrocytes*/metabolism
Neurons*/metabolism
Rats ; Animals ; Male ; Vasopressins/metabolism ; Aquaporin 4/genetics ; Aquaporin 4/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Graphene Oxide Nanosheets Reduce Astrocyte Reactivity to Inflammation and Ameliorate Experimental Autoimmune Encephalomyelitis.
Autorzy:
Di Mauro G; International School for Advanced Studies (SISSA/ISAS), 34136Trieste, Italy.
Amoriello R; International School for Advanced Studies (SISSA/ISAS), 34136Trieste, Italy.; Dipartimento di Medicina Sperimentale e Clinica, University of Florence, 50139Florence, Italy.
Lozano N; Catalan Institute of Nanoscience and Nanotechnology (ICN2), 08193Barcelona, Spain.
Carnasciali A; Dipartimento di Medicina Sperimentale e Clinica, University of Florence, 50139Florence, Italy.
Guasti D; Dipartimento di Medicina Sperimentale e Clinica, University of Florence, 50139Florence, Italy.
Becucci M; Dipartimento di Chimica 'Ugo Schiff', DICUS, University of Florence, 50139Florence, Italy.
Cellot G; International School for Advanced Studies (SISSA/ISAS), 34136Trieste, Italy.
Kostarelos K; Catalan Institute of Nanoscience and Nanotechnology (ICN2), 08193Barcelona, Spain.; Nanomedicine Lab, and Faculty of Biology, Medicine & Health, The National Graphene Institute, University of Manchester, ManchesterM13 9PL, United Kingdom.
Ballerini C; Dipartimento di Medicina Sperimentale e Clinica, University of Florence, 50139Florence, Italy.
Ballerini L; International School for Advanced Studies (SISSA/ISAS), 34136Trieste, Italy.
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Źródło:
ACS nano [ACS Nano] 2023 Feb 14; Vol. 17 (3), pp. 1965-1978. Date of Electronic Publication: 2023 Jan 24.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Astrocytes*
Encephalomyelitis, Autoimmune, Experimental*/drug therapy
Animals ; Neuroglia ; Inflammation/drug therapy
Czasopismo naukowe
Szczegóły
Tytuł:
Up-Regulation of Astrocytic Fgfr4 Expression in Adult Mice after Spinal Cord Injury.
Autorzy:
Bringuier CM; MMDN, Univ. Montpellier, EPHE, INSERM, 34095 Montpellier, France.
Noristani HN; MMDN, Univ. Montpellier, EPHE, INSERM, 34095 Montpellier, France.
Perez JC; MMDN, Univ. Montpellier, EPHE, INSERM, 34095 Montpellier, France.
Cardoso M; UMR 5221, Univ. Montpellier, CNRS, 34095 Montpellier, France.
Goze-Bac C; UMR 5221, Univ. Montpellier, CNRS, 34095 Montpellier, France.
Gerber YN; MMDN, Univ. Montpellier, EPHE, INSERM, 34095 Montpellier, France.
Perrin FE; MMDN, Univ. Montpellier, EPHE, INSERM, 34095 Montpellier, France.; Institut Universitaire de France (IUF), 75005 Paris, France.
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Źródło:
Cells [Cells] 2023 Feb 06; Vol. 12 (4). Date of Electronic Publication: 2023 Feb 06.
Typ publikacji:
Journal Article
MeSH Terms:
Astrocytes*/metabolism
Spinal Cord Injuries*/therapy
Mice ; Animals ; Up-Regulation ; Receptor, Fibroblast Growth Factor, Type 4/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Blood-brain barrier dysfunction promotes astrocyte senescence through albumin-induced TGFβ signaling activation.
Autorzy:
Preininger MK; Department of Integrative Biology, University of California, Berkeley, Berkeley, California, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, USA.
Zaytseva D; Department of Integrative Biology, University of California, Berkeley, Berkeley, California, USA.; Department of Biology, San Francisco State University, San Francisco, California, USA.
Lin JM; Department of Integrative Biology, University of California, Berkeley, Berkeley, California, USA.
Kaufer D; Department of Integrative Biology, University of California, Berkeley, Berkeley, California, USA.; Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, California, USA.
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Źródło:
Aging cell [Aging Cell] 2023 Feb; Vol. 22 (2), pp. e13747. Date of Electronic Publication: 2023 Jan 05.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Blood-Brain Barrier*/metabolism
Astrocytes*/metabolism
Rats ; Mice ; Animals ; Brain/metabolism ; Transforming Growth Factor beta/metabolism ; Transforming Growth Factor beta/pharmacology ; Serum Albumin/metabolism ; Serum Albumin/pharmacology ; Cellular Senescence
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Identification of astrocyte regulators by nucleic acid cytometry.
Autorzy:
Clark IC; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Bioengineering and Therapeutic Sciences, School of Pharmacy, University of California San Francisco, San Francisco, CA, USA.; Department of Bioengineering, College of Engineering, California Institute for Quantitative Biosciences, QB3, University of California Berkeley, Berkeley, CA, USA.
Wheeler MA; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Lee HG; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Li Z; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Sanmarco LM; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Thaploo S; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Polonio CM; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Shin SW; Department of Bioengineering, College of Engineering, California Institute for Quantitative Biosciences, QB3, University of California Berkeley, Berkeley, CA, USA.
Scalisi G; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Henry AR; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Rone JM; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Giovannoni F; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Charabati M; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Akl CF; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Aleman DM; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Zandee SEJ; Neuroimmunology Research Lab, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, Quebec, Canada.
Prat A; Neuroimmunology Research Lab, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, Quebec, Canada.
Douek DC; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Boritz EA; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Quintana FJ; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. .; Broad Institute of MIT and Harvard, Cambridge, MA, USA. .
Abate AR; Department of Bioengineering and Therapeutic Sciences, School of Pharmacy, University of California San Francisco, San Francisco, CA, USA. .
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Źródło:
Nature [Nature] 2023 Feb; Vol. 614 (7947), pp. 326-333. Date of Electronic Publication: 2023 Jan 04.
Typ publikacji:
Journal Article
MeSH Terms:
Astrocytes*/metabolism
Astrocytes*/pathology
Encephalomyelitis, Autoimmune, Experimental*
Multiple Sclerosis*/pathology
Microfluidics*/methods
Single-Cell Gene Expression Analysis*/methods
Nucleic Acids*/analysis
Animals ; Humans ; Mice ; Gene Expression Regulation ; Mice, Knockout ; Gene Editing
Czasopismo naukowe
Szczegóły
Tytuł:
Cholesterol-24-hydroxylase (CYP46) in the old brain: Analysis of positive populations and factors triggering its expression in astrocytes.
Autorzy:
Cataldi GG; Instituto Ferreyra, INIMEC-CONICET-UNC, Universidad Nacional de Córdoba, Córdoba, Argentina.
Elorza SD; Instituto Ferreyra, INIMEC-CONICET-UNC, Universidad Nacional de Córdoba, Córdoba, Argentina.
Toledano-Zaragoza A; Molecular Neuropathology Unit, Physiological and Pathological Processes Program, Centro de Biología Molecular Severo Ochoa (CBMSO-CSIC), Madrid, Spain.
de Olmos S; Instituto Ferreyra, INIMEC-CONICET-UNC, Universidad Nacional de Córdoba, Córdoba, Argentina.
Cragnolini AB; Instituto de Investigaciones Biológicas y Tecnológicas, CONICET-UNC, Facultad de Ciencias Exactas, Físicas y Naturales, Universidad Nacional de Córdoba, Córdoba, Argentina.
Martín MG; Instituto Ferreyra, INIMEC-CONICET-UNC, Universidad Nacional de Córdoba, Córdoba, Argentina.
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Źródło:
The Journal of comparative neurology [J Comp Neurol] 2023 Feb; Vol. 531 (3), pp. 486-499. Date of Electronic Publication: 2022 Dec 01.
Typ publikacji:
Journal Article
MeSH Terms:
Astrocytes*/metabolism
Brain*/metabolism
Cholesterol 24-Hydroxylase*/metabolism
Animals ; Mice ; Cholesterol/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Mutations in the transcriptional regulator MeCP2 severely impact key cellular and molecular signatures of human astrocytes during maturation.
Autorzy:
Sun J; Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY 11794, USA.
Osenberg S; Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY 11794, USA; Departments of Pediatrics-Neurology, Baylor College of Medicine, Houston, TX 77030, USA; Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX 77030, USA.
Irwin A; Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY 11794, USA.
Ma LH; Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX 77030, USA; Advanced Technology Cores, Baylor College of Medicine, Houston, TX 77030, USA.
Lee N; Departments of Pediatrics-Neurology, Baylor College of Medicine, Houston, TX 77030, USA; Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX 77030, USA.
Xiang Y; Department of Genetics, Yale Stem Cell Center, Yale School of Medicine, New Haven, CT 06520, USA.
Li F; Advanced Technology Cores, Baylor College of Medicine, Houston, TX 77030, USA; Center for Drug Discovery and Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030, USA.
Wan YW; Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX 77030, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Park IH; Department of Genetics, Yale Stem Cell Center, Yale School of Medicine, New Haven, CT 06520, USA.
Maletic-Savatic M; Departments of Pediatrics-Neurology, Baylor College of Medicine, Houston, TX 77030, USA; Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX 77030, USA. Electronic address: .
Ballas N; Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY 11794, USA. Electronic address: .
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Źródło:
Cell reports [Cell Rep] 2023 Jan 31; Vol. 42 (1), pp. 111942. Date of Electronic Publication: 2023 Jan 05.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Astrocytes*/metabolism
Rett Syndrome*/genetics
Rett Syndrome*/metabolism
Humans ; Methyl-CpG-Binding Protein 2/genetics ; Methyl-CpG-Binding Protein 2/metabolism ; Neurons/metabolism ; Brain/metabolism ; Mutation/genetics
Czasopismo naukowe
Szczegóły
Tytuł:
Astrocytic cell adhesion genes linked to schizophrenia correlate with synaptic programs in neurons.
Autorzy:
Pietiläinen O; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Stem Cell and Regenerative Biology and the Harvard Institute for Stem Cell Biology, Harvard University, Cambridge, MA 02138, USA; Neuroscience Center, Helsinki Institute for Life Science, University of Helsinki, 00290 Helsinki, Finland. Electronic address: .
Trehan A; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Stem Cell and Regenerative Biology and the Harvard Institute for Stem Cell Biology, Harvard University, Cambridge, MA 02138, USA.
Meyer D; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Mitchell J; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Stem Cell and Regenerative Biology and the Harvard Institute for Stem Cell Biology, Harvard University, Cambridge, MA 02138, USA.
Tegtmeyer M; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Stem Cell and Regenerative Biology and the Harvard Institute for Stem Cell Biology, Harvard University, Cambridge, MA 02138, USA; Centre for Gene Therapy and Regenerative Medicine, King's College, London WC2R 2LS, UK.
Valakh V; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Gebre H; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Chen T; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Vartiainen E; Neuroscience Center, Helsinki Institute for Life Science, University of Helsinki, 00290 Helsinki, Finland.
Farhi SL; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Eggan K; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Stem Cell and Regenerative Biology and the Harvard Institute for Stem Cell Biology, Harvard University, Cambridge, MA 02138, USA.
McCarroll SA; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Nehme R; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Stem Cell and Regenerative Biology and the Harvard Institute for Stem Cell Biology, Harvard University, Cambridge, MA 02138, USA. Electronic address: .
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Źródło:
Cell reports [Cell Rep] 2023 Jan 31; Vol. 42 (1), pp. 111988. Date of Electronic Publication: 2023 Jan 12.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Astrocytes*/metabolism
Schizophrenia*/genetics
Schizophrenia*/metabolism
Humans ; Cell Adhesion/genetics ; Neurons/metabolism ; Neuroglia ; Synapses/physiology
Czasopismo naukowe
Szczegóły
Tytuł:
Induced Remodelling of Astrocytes In Vitro and In Vivo by Manipulation of Astrocytic RhoA Activity.
Autorzy:
Domingos C; Institute of Cellular Neurosciences, Medical Faculty, University of Bonn, 53127 Bonn, Germany.
Müller FE; Cellular Neurophysiology, Hannover Medical School, 30625 Hannover, Germany.
Passlick S; Institute of Cellular Neurosciences, Medical Faculty, University of Bonn, 53127 Bonn, Germany.
Wachten D; Institute of Innate Immunity, Medical Faculty, University of Bonn, 53127 Bonn, Germany.
Ponimaskin E; Cellular Neurophysiology, Hannover Medical School, 30625 Hannover, Germany.
Schwarz MK; Institute of Experimental Epileptology and Cognition Research (EECR), Medical Faculty, University of Bonn, 53127 Bonn, Germany.
Schoch S; Institute of Neuropathology, University of Bonn Medical School, 53127 Bonn, Germany.
Zeug A; Cellular Neurophysiology, Hannover Medical School, 30625 Hannover, Germany.
Henneberger C; Institute of Cellular Neurosciences, Medical Faculty, University of Bonn, 53127 Bonn, Germany.; German Center for Neurodegenerative Diseases (DZNE), 53127 Bonn, Germany.
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Źródło:
Cells [Cells] 2023 Jan 15; Vol. 12 (2). Date of Electronic Publication: 2023 Jan 15.
Typ publikacji:
Journal Article
MeSH Terms:
Astrocytes*/metabolism
Neurons*
Cytoskeleton ; Signal Transduction
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Nanotopography and Microconfinement Impact on Primary Hippocampal Astrocyte Morphology, Cytoskeleton and Spontaneous Calcium Wave Signalling.
Autorzy:
Previdi A; CIMaINa and Dipartimento di Fisica, Università degli Studi di Milano, Via Celoria 16, 20133 Milano, Italy.
Borghi F; CIMaINa and Dipartimento di Fisica, Università degli Studi di Milano, Via Celoria 16, 20133 Milano, Italy.
Profumo F; CIMaINa and Dipartimento di Fisica, Università degli Studi di Milano, Via Celoria 16, 20133 Milano, Italy.
Schulte C; CIMaINa and Dipartimento di Fisica, Università degli Studi di Milano, Via Celoria 16, 20133 Milano, Italy.
Piazzoni C; CIMaINa and Dipartimento di Fisica, Università degli Studi di Milano, Via Celoria 16, 20133 Milano, Italy.
Lamanna J; Centre for Behavioural Neuroscience and Communication (BNC), Università Vita-Salute San Raffaele, 20132 Milano, Italy.
Racchetti G; Division of Neuroscience, Scientific Institute Ospedale San Raffaele, 20132 Milano, Italy.
Malgaroli A; Centre for Behavioural Neuroscience and Communication (BNC), Università Vita-Salute San Raffaele, 20132 Milano, Italy.
Milani P; CIMaINa and Dipartimento di Fisica, Università degli Studi di Milano, Via Celoria 16, 20133 Milano, Italy.
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Źródło:
Cells [Cells] 2023 Jan 12; Vol. 12 (2). Date of Electronic Publication: 2023 Jan 12.
Typ publikacji:
Journal Article
MeSH Terms:
Astrocytes*/metabolism
Calcium Signaling*
Rats ; Animals ; Cytoskeleton/metabolism ; Microtubules/metabolism ; Hippocampus/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Human Astrocyte Spheroids as Suitable In Vitro Screening Model to Evaluate Synthetic Cannabinoid MAM2201-Induced Effects on CNS.
Autorzy:
De Simone U; Laboratory of Clinical and Experimental Toxicology, and Pavia Poison Centre-National Toxicology Information Centre, Toxicology Unit, Istituti Clinici Scientifici Maugeri IRCCS, 27100 Pavia, Italy.
Pignatti P; Allergy and Immunology Unit, Istituti Clinici Scientifici Maugeri IRCCS, 27100 Pavia, Italy.
Villani L; Pathology Unit, Istituti Clinici Scientifici Maugeri IRCCS, 27100 Pavia, Italy.
Russo LA; Pathology Unit, Istituti Clinici Scientifici Maugeri IRCCS, 27100 Pavia, Italy.
Sargenti A; CellDynamics srl, 40129 Bologna, Italy.
Bonetti S; CNR-ISMN, Institute for Nanostructured Materials, 40129 Bologna, Italy.
Buscaglia E; Laboratory of Clinical and Experimental Toxicology, and Pavia Poison Centre-National Toxicology Information Centre, Toxicology Unit, Istituti Clinici Scientifici Maugeri IRCCS, 27100 Pavia, Italy.
Coccini T; Laboratory of Clinical and Experimental Toxicology, and Pavia Poison Centre-National Toxicology Information Centre, Toxicology Unit, Istituti Clinici Scientifici Maugeri IRCCS, 27100 Pavia, Italy.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jan 11; Vol. 24 (2). Date of Electronic Publication: 2023 Jan 11.
Typ publikacji:
Journal Article
MeSH Terms:
Astrocytes*/metabolism
Cannabinoids*/toxicity
Cannabinoids*/chemistry
Humans ; Naphthalenes/toxicity ; Naphthalenes/metabolism ; Neurons/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Astroglial cannabinoid signaling and behavior.
Autorzy:
Ramon-Duaso C; Cell-Type Mechanisms in Normal and Pathological Behavior Research Group, Neuroscience Programme, IMIM Hospital del Mar Medical Research Institute, Barcelona, Spain.
Conde-Moro AR; Cell-Type Mechanisms in Normal and Pathological Behavior Research Group, Neuroscience Programme, IMIM Hospital del Mar Medical Research Institute, Barcelona, Spain.
Busquets-Garcia A; Cell-Type Mechanisms in Normal and Pathological Behavior Research Group, Neuroscience Programme, IMIM Hospital del Mar Medical Research Institute, Barcelona, Spain.
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Źródło:
Glia [Glia] 2023 Jan; Vol. 71 (1), pp. 60-70. Date of Electronic Publication: 2022 Mar 16.
Typ publikacji:
Review; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Astrocytes*/physiology
Cannabinoids*/pharmacology
Neurons/physiology ; Signal Transduction ; Receptors, Cannabinoid
Czasopismo naukowe
Szczegóły
Tytuł:
Endocannabinoid signaling in astrocytes.
Autorzy:
Eraso-Pichot A; U1215 Neurocentre Magendie, Institut national de la santé et de la recherche médicale (INSERM), Bordeaux, France.; University of Bordeaux, Bordeaux, France.
Pouvreau S; U1215 Neurocentre Magendie, Institut national de la santé et de la recherche médicale (INSERM), Bordeaux, France.; University of Bordeaux, Bordeaux, France.
Olivera-Pinto A; U1215 Neurocentre Magendie, Institut national de la santé et de la recherche médicale (INSERM), Bordeaux, France.; University of Bordeaux, Bordeaux, France.
Gomez-Sotres P; U1215 Neurocentre Magendie, Institut national de la santé et de la recherche médicale (INSERM), Bordeaux, France.; University of Bordeaux, Bordeaux, France.
Skupio U; U1215 Neurocentre Magendie, Institut national de la santé et de la recherche médicale (INSERM), Bordeaux, France.; University of Bordeaux, Bordeaux, France.
Marsicano G; U1215 Neurocentre Magendie, Institut national de la santé et de la recherche médicale (INSERM), Bordeaux, France.; University of Bordeaux, Bordeaux, France.
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Źródło:
Glia [Glia] 2023 Jan; Vol. 71 (1), pp. 44-59. Date of Electronic Publication: 2022 Jul 13.
Typ publikacji:
Review; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Astrocytes*/metabolism
Cannabinoids*
Endocannabinoids/metabolism ; Neurons/metabolism ; Calcium/metabolism ; Calcium Signaling/physiology
Czasopismo naukowe
Szczegóły
Wyświetlanie 1-20 z 68251

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