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Wyszukujesz frazę ""Autophagy"" wg kryterium: Temat


Starter badań:

Tytuł:
Dysregulation of the progranulin-driven autophagy-lysosomal pathway mediates secretion of the nuclear protein TDP-43.
Autorzy:
Tanaka Y; Biochemistry Unit, Faculty of Veterinary Medicine, Okayama University of Science, Imabari-shi, Ehime, Japan. Electronic address: .
Ito SI; Biochemistry Unit, Faculty of Veterinary Medicine, Okayama University of Science, Imabari-shi, Ehime, Japan.
Honma Y; Biochemistry Unit, Faculty of Veterinary Medicine, Okayama University of Science, Imabari-shi, Ehime, Japan.
Hasegawa M; Department of Brain and Neurosciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Kametani F; Department of Brain and Neurosciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Suzuki G; Department of Brain and Neurosciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Kozuma L; Biochemistry Unit, Faculty of Veterinary Medicine, Okayama University of Science, Imabari-shi, Ehime, Japan.
Takeya K; Biochemistry Unit, Faculty of Veterinary Medicine, Okayama University of Science, Imabari-shi, Ehime, Japan.
Eto M; Biochemistry Unit, Faculty of Veterinary Medicine, Okayama University of Science, Imabari-shi, Ehime, Japan.
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Źródło:
The Journal of biological chemistry [J Biol Chem] 2023 Nov; Vol. 299 (11), pp. 105272. Date of Electronic Publication: 2023 Sep 20.
Typ publikacji:
Journal Article
MeSH Terms:
Autophagy*/drug effects
Autophagy*/genetics
DNA-Binding Proteins*/genetics
DNA-Binding Proteins*/metabolism
Lysosomes*/metabolism
Progranulins*/genetics
Progranulins*/metabolism
Humans ; HeLa Cells ; Intercellular Signaling Peptides and Proteins/genetics ; Intercellular Signaling Peptides and Proteins/metabolism ; Microtubule-Associated Proteins/genetics ; Microtubule-Associated Proteins/metabolism ; Gene Expression Regulation/drug effects ; Extracellular Vesicles/metabolism ; Enzyme Inhibitors/pharmacology ; Autophagosomes/drug effects ; Autophagosomes/metabolism ; Autophagy-Related Proteins/genetics ; Autophagy-Related Proteins/metabolism
Czasopismo naukowe
Tytuł:
The Intrinsically Disordered N Terminus in Atg12 from Yeast Is Necessary for the Functional Structure of the Protein.
Autorzy:
Popelka H; Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.
Lahiri V; Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.; Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Hawkins WD; Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.; Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
da Veiga Leprevost F; Department of Pathology, Michigan Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Nesvizhskii AI; Department of Pathology, Michigan Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Klionsky DJ; Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.; Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Oct 10; Vol. 24 (20). Date of Electronic Publication: 2023 Oct 10.
Typ publikacji:
Journal Article
MeSH Terms:
Autophagy-Related Protein 12*
Saccharomyces cerevisiae*/genetics
Saccharomyces cerevisiae*/metabolism
Saccharomyces cerevisiae Proteins*/metabolism
Autophagy ; Autophagy-Related Protein 5 ; Autophagy-Related Proteins/genetics ; Ubiquitin/genetics ; Ubiquitin/metabolism ; Ubiquitin-Protein Ligases
Czasopismo naukowe
Tytuł:
Integrated Multi-Omics Analyses Reveal That Autophagy-Mediated Cellular Metabolism Is Required for the Initiation of Pollen Germination.
Autorzy:
Zhou X; College of Life Sciences, South-Central Minzu University, Wuhan 430074, China.
Zhang Q; College of Life Sciences, South-Central Minzu University, Wuhan 430074, China.
Zhao Y; College of Life Sciences, South-Central Minzu University, Wuhan 430074, China.
Ding S; College of Life Sciences, South-Central Minzu University, Wuhan 430074, China.
Yu GH; College of Life Sciences, South-Central Minzu University, Wuhan 430074, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Oct 09; Vol. 24 (19). Date of Electronic Publication: 2023 Oct 09.
Typ publikacji:
Journal Article
MeSH Terms:
Multiomics*
Autophagy*/genetics
Autophagy-Related Proteins/genetics ; Autophagy-Related Protein 12/genetics ; Pollen/genetics ; Pollen/metabolism ; Germination/genetics
Czasopismo naukowe
Tytuł:
Targeting RPA promotes autophagic flux and the antitumor response to radiation in nasopharyngeal carcinoma.
Autorzy:
Feng Y; Department of Clinical Laboratory, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510655, China.; Guangdong Institute of Gastroenterology, Guangzhou, 510655, China.; Department of General Surgery, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510655, China.; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510655, China.; Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510655, China.
Jiang Y; Guangdong Institute of Gastroenterology, Guangzhou, 510655, China.; Department of General Surgery, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510655, China.; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510655, China.; Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510655, China.; Department of General Surgery (Department of Gastric Surgery Section 2, ), The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510655, China.
Liu J; Department of Clinical Laboratory, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510655, China.; Guangdong Institute of Gastroenterology, Guangzhou, 510655, China.; Department of General Surgery, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510655, China.; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510655, China.; Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510655, China.
Liu J; Department of Clinical Laboratory, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510655, China.; Guangdong Institute of Gastroenterology, Guangzhou, 510655, China.; Department of General Surgery, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510655, China.; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510655, China.; Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510655, China.
Shi M; Department of Clinical Laboratory, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510655, China.; Guangdong Institute of Gastroenterology, Guangzhou, 510655, China.; Department of General Surgery, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510655, China.; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510655, China.; Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510655, China.
Chen J; Department of Clinical Laboratory, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510655, China.; Guangdong Institute of Gastroenterology, Guangzhou, 510655, China.; Department of General Surgery, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510655, China.; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510655, China.; Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510655, China.
Zhang J; Department of Clinical Laboratory, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510655, China.; Guangdong Institute of Gastroenterology, Guangzhou, 510655, China.; Department of General Surgery, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510655, China.; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510655, China.; Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510655, China.
Tian Y; Department of Clinical Laboratory, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510655, China.; Guangdong Institute of Gastroenterology, Guangzhou, 510655, China.; Department of General Surgery, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510655, China.; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510655, China.; Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510655, China.
Yang X; Department of Clinical Laboratory, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510655, China. .; Guangdong Institute of Gastroenterology, Guangzhou, 510655, China. .; Department of General Surgery, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510655, China. .; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510655, China. .; Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510655, China. .
Liu H; Department of Clinical Laboratory, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510655, China. .; Guangdong Institute of Gastroenterology, Guangzhou, 510655, China. .; Department of General Surgery, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510655, China. .; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510655, China. .; Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510655, China. .
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Źródło:
Journal of translational medicine [J Transl Med] 2023 Oct 19; Vol. 21 (1), pp. 738. Date of Electronic Publication: 2023 Oct 19.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antineoplastic Agents*/therapeutic use
Autophagy*/drug effects
Autophagy*/genetics
Nasopharyngeal Carcinoma*/drug therapy
Nasopharyngeal Carcinoma*/genetics
Nasopharyngeal Carcinoma*/radiotherapy
Nasopharyngeal Neoplasms*/drug therapy
Nasopharyngeal Neoplasms*/genetics
Nasopharyngeal Neoplasms*/radiotherapy
Radiation Tolerance*/drug effects
Radiation Tolerance*/genetics
Replication Protein A*/antagonists & inhibitors
Replication Protein A*/genetics
Humans ; Apoptosis ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic ; Autophagy-Related Protein 5/genetics
Czasopismo naukowe
Tytuł:
Nix interacts with WIPI2 to induce mitophagy.
Autorzy:
Bunker EN; Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Le Guerroué F; Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Wang C; Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Strub MP; Biochemistry and Biophysics Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Werner A; Stem Cell Biochemistry Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
Tjandra N; Biochemistry and Biophysics Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Youle RJ; Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
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Źródło:
The EMBO journal [EMBO J] 2023 Nov 15; Vol. 42 (22), pp. e113491. Date of Electronic Publication: 2023 Aug 25.
Typ publikacji:
Journal Article
MeSH Terms:
Mitophagy*
Autophagy*
Mitochondria/metabolism ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Autophagy-Related Protein 8 Family/metabolism ; Mitochondrial Proteins/genetics ; Mitochondrial Proteins/metabolism
Czasopismo naukowe
Tytuł:
Local membrane source gathering by p62 body drives autophagosome formation.
Autorzy:
Feng X; State Key Laboratory of Pathogenesis, Prevention and Treatment of Central Asian High Incidence Diseases, Clinical Medical Research Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830011, Xinjiang, China.; Basic Medical College, Xinjiang Medical University, Urumqi, 830011, Xinjiang, China.
Sun D; Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307, Dresden, Germany. .
Li Y; State Key Laboratory of Proteomics, National Center for Protein Sciences (Beijing), Research Unit of Proteomics & Research and Development of New Drug of Chinese Academy of Medical Sciences, Beijing Proteome Research Center, Institute of Lifeomics, 102206, Beijing, China.
Zhang J; State Key Laboratory of Pathogenesis, Prevention and Treatment of Central Asian High Incidence Diseases, Clinical Medical Research Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830011, Xinjiang, China.; Basic Medical College, Xinjiang Medical University, Urumqi, 830011, Xinjiang, China.
Liu S; State Key Laboratory of Pathogenesis, Prevention and Treatment of Central Asian High Incidence Diseases, Clinical Medical Research Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830011, Xinjiang, China.; Basic Medical College, Xinjiang Medical University, Urumqi, 830011, Xinjiang, China.
Zhang D; School of Life Sciences, Tsinghua University, 100084, Beijing, China.
Zheng J; School of Life Sciences, Tsinghua University, 100084, Beijing, China.
Xi Q; State Key Laboratory of Pathogenesis, Prevention and Treatment of Central Asian High Incidence Diseases, Clinical Medical Research Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830011, Xinjiang, China.; Basic Medical College, Xinjiang Medical University, Urumqi, 830011, Xinjiang, China.
Liang H; School of Life Sciences, Tsinghua University, 100084, Beijing, China.
Zhao W; School of Life Sciences, Tsinghua University, 100084, Beijing, China.
Li Y; School of Life Sciences, Tsinghua University, 100084, Beijing, China.
Xu M; State Key Laboratory of Pathogenesis, Prevention and Treatment of Central Asian High Incidence Diseases, Clinical Medical Research Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830011, Xinjiang, China.; Basic Medical College, Xinjiang Medical University, Urumqi, 830011, Xinjiang, China.
He J; State Key Laboratory of Pathogenesis, Prevention and Treatment of Central Asian High Incidence Diseases, Clinical Medical Research Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830011, Xinjiang, China.; Basic Medical College, Xinjiang Medical University, Urumqi, 830011, Xinjiang, China.
Liu T; State Key Laboratory of Pathogenesis, Prevention and Treatment of Central Asian High Incidence Diseases, Clinical Medical Research Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830011, Xinjiang, China.; Basic Medical College, Xinjiang Medical University, Urumqi, 830011, Xinjiang, China.
Hasim A; Basic Medical College, Xinjiang Medical University, Urumqi, 830011, Xinjiang, China.; Department of Pathology, School of Basic Medicine, Xinjiang Medical University, Urumqi, 830011, Xinjiang, China.
Ma M; Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China.
Xu P; State Key Laboratory of Proteomics, National Center for Protein Sciences (Beijing), Research Unit of Proteomics & Research and Development of New Drug of Chinese Academy of Medical Sciences, Beijing Proteome Research Center, Institute of Lifeomics, 102206, Beijing, China. .
Mi N; State Key Laboratory of Pathogenesis, Prevention and Treatment of Central Asian High Incidence Diseases, Clinical Medical Research Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830011, Xinjiang, China. .; Basic Medical College, Xinjiang Medical University, Urumqi, 830011, Xinjiang, China. .; Key Laboratory of High Incidence Disease Research in Xinjiang (Xinjiang Medical University), Ministry of Education, Urumqi, 830011, Xinjiang, China. .
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Źródło:
Nature communications [Nat Commun] 2023 Nov 13; Vol. 14 (1), pp. 7338. Date of Electronic Publication: 2023 Nov 13.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Autophagosomes*/metabolism
Autophagy*/physiology
Macroautophagy ; Phagosomes/metabolism ; Autophagy-Related Proteins/genetics ; Autophagy-Related Proteins/metabolism ; Lipids
Czasopismo naukowe
Tytuł:
Involvement of Lipophagy and Chaperone-Mediated Autophagy in the Pathogenesis of Non-Alcoholic Fatty Liver Disease by Regulation of Lipid Droplets.
Autorzy:
Mastoridou EM; Department of Anatomy-Histology-Embryology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece.
Goussia AC; Department of Pathology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece.
Kanavaros P; Department of Anatomy-Histology-Embryology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece.
Charchanti AV; Department of Anatomy-Histology-Embryology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Nov 02; Vol. 24 (21). Date of Electronic Publication: 2023 Nov 02.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Non-alcoholic Fatty Liver Disease*/metabolism
Chaperone-Mediated Autophagy*
Humans ; Lipid Droplets/metabolism ; Lipid Metabolism ; Hepatocytes/metabolism ; Autophagy/physiology ; Perilipins/metabolism ; Liver/metabolism
Czasopismo naukowe
Tytuł:
Activation of Chaperone-Mediated Autophagy Inhibits the Aryl Hydrocarbon Receptor Function by Degrading This Receptor in Human Lung Epithelial Carcinoma A549 Cells.
Autorzy:
Xiong R; Department of Pharmaceutics & Medicinal Chemistry, Thomas J. Long School of Pharmacy, University of the Pacific, Stockton, CA 95211, USA.
Shao D; Department of Pharmaceutics & Medicinal Chemistry, Thomas J. Long School of Pharmacy, University of the Pacific, Stockton, CA 95211, USA.
Do S; Department of Pharmaceutics & Medicinal Chemistry, Thomas J. Long School of Pharmacy, University of the Pacific, Stockton, CA 95211, USA.
Chan WK; Department of Pharmaceutics & Medicinal Chemistry, Thomas J. Long School of Pharmacy, University of the Pacific, Stockton, CA 95211, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Oct 12; Vol. 24 (20). Date of Electronic Publication: 2023 Oct 12.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma*
Chaperone-Mediated Autophagy*
Lung Neoplasms*/metabolism
Humans ; A549 Cells ; Autophagy/genetics ; Chloroquine/pharmacology ; Ligands ; Lung/pathology ; Receptors, Aryl Hydrocarbon/genetics ; Receptors, Aryl Hydrocarbon/metabolism
Czasopismo naukowe
Tytuł:
Chaperone-mediated autophagy dysregulation during aging impairs hepatic fatty acid oxidation via accumulation of NCoR1.
Autorzy:
Choi YJ; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea.
Yun SH; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea.
Yu J; Division of Life Science, Korea Polar Research Institute, Incheon 21990, Republic of Korea.
Mun Y; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea.
Lee W; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea.
Park CJ; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea.
Han BW; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea.
Lee BH; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea. Electronic address: .
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Źródło:
Molecular metabolism [Mol Metab] 2023 Oct; Vol. 76, pp. 101784. Date of Electronic Publication: 2023 Jul 29.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Chaperone-Mediated Autophagy*
Animals ; Mice ; Autophagy ; PPAR alpha/genetics ; Aging ; Liver ; Lipid Metabolism ; Fatty Acids/pharmacology
Czasopismo naukowe
Tytuł:
ULK1 forms distinct oligomeric states and nanoscopic structures during autophagy initiation.
Autorzy:
Banerjee C; School of Physics and Astronomy, University of Minnesota, Twin Cities, Minneapolis, MN, USA.
Mehra D; School of Physics and Astronomy, University of Minnesota, Twin Cities, Minneapolis, MN, USA.; Department of Biomedical Engineering and Physiology, Mayo Clinic, Rochester, MN, USA.
Song D; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Twin Cities, Minneapolis, MN, USA.
Mancebo A; School of Physics and Astronomy, University of Minnesota, Twin Cities, Minneapolis, MN, USA.
Park JM; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Twin Cities, Minneapolis, MN, USA.
Kim DH; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Twin Cities, Minneapolis, MN, USA.
Puchner EM; School of Physics and Astronomy, University of Minnesota, Twin Cities, Minneapolis, MN, USA.
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Źródło:
Science advances [Sci Adv] 2023 Sep 29; Vol. 9 (39), pp. eadh4094. Date of Electronic Publication: 2023 Sep 29.
Typ publikacji:
Journal Article
MeSH Terms:
Autophagy*
Amino Acids/deficiency ; Autophagy-Related Protein-1 Homolog/metabolism ; Autophagy-Related Proteins/metabolism ; Humans
Czasopismo naukowe
Tytuł:
Model Organisms to Study Autophagy.
Autorzy:
Xiong Q; Shanxi Provincial Key Laboratory of Medical Molecular Cell Biology, Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institutes of Biomedical Sciences, Shanxi University, No. 92 Wucheng Road, Taiyuan 030006, China.
Eichinger L; Center for Biochemistry, Medical Faculty, University of Cologne, Joseph-Stelzmann-Str. 52, 50931 Cologne, Germany.
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Źródło:
Cells [Cells] 2023 Sep 05; Vol. 12 (18). Date of Electronic Publication: 2023 Sep 05.
Typ publikacji:
Editorial; Research Support, Non-U.S. Gov't
MeSH Terms:
Autophagy*
Eukaryotic Cells*
Humans ; Autophagy-Related Proteins ; Kinetics
Raport
Tytuł:
Interactome of Arabidopsis ATG5 Suggests Functions beyond Autophagy.
Autorzy:
Elander PH; Department of Molecular Sciences, Uppsala BioCenter, Swedish University of Agricultural Sciences and Linnean Center for Plant Biology, 750-07 Uppsala, Sweden.
Holla S; Department of Molecular Sciences, Uppsala BioCenter, Swedish University of Agricultural Sciences and Linnean Center for Plant Biology, 750-07 Uppsala, Sweden.
Sabljić I; Department of Molecular Sciences, Uppsala BioCenter, Swedish University of Agricultural Sciences and Linnean Center for Plant Biology, 750-07 Uppsala, Sweden.
Gutierrez-Beltran E; Instituto de Bioquımica Vegetal y Fotosıntesis, Universidad de Sevilla and Consejo Superior de Investigaciones Cientıficas, 41092 Sevilla, Spain.; Departamento de Bioquimica Vegetal y Biologia Molecular, Facultad de Biologia, Universidad de Sevilla, 41012 Sevilla, Spain.
Willems P; Department of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Ghent, Belgium.; Department of Biomolecular Medicine, Ghent University, 9000 Ghent, Belgium.
Bozhkov PV; Department of Molecular Sciences, Uppsala BioCenter, Swedish University of Agricultural Sciences and Linnean Center for Plant Biology, 750-07 Uppsala, Sweden.
Minina EA; Department of Molecular Sciences, Uppsala BioCenter, Swedish University of Agricultural Sciences and Linnean Center for Plant Biology, 750-07 Uppsala, Sweden.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Aug 01; Vol. 24 (15). Date of Electronic Publication: 2023 Aug 01.
Typ publikacji:
Journal Article
MeSH Terms:
Arabidopsis*/metabolism
Autophagy-Related Protein 5*/genetics
Autophagy-Related Protein 5*/metabolism
Autophagy/genetics ; Chromatography, Liquid ; Tandem Mass Spectrometry
Czasopismo naukowe
Tytuł:
LC3B is lipidated to large lipid droplets during prolonged starvation for noncanonical autophagy.
Autorzy:
Omrane M; Laboratoire de Physique de l'École Normale Supérieure, ENS, Université PSL, CNRS, Sorbonne Université, Université Paris Cité, 75005 Paris, France.
Ben M'Barek K; Laboratoire de Physique de l'École Normale Supérieure, ENS, Université PSL, CNRS, Sorbonne Université, Université Paris Cité, 75005 Paris, France.
Santinho A; Laboratoire de Physique de l'École Normale Supérieure, ENS, Université PSL, CNRS, Sorbonne Université, Université Paris Cité, 75005 Paris, France.
Nguyen N; Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06510, USA.
Nag S; Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06510, USA.
Melia TJ; Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06510, USA.
Thiam AR; Laboratoire de Physique de l'École Normale Supérieure, ENS, Université PSL, CNRS, Sorbonne Université, Université Paris Cité, 75005 Paris, France. Electronic address: .
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Źródło:
Developmental cell [Dev Cell] 2023 Jul 24; Vol. 58 (14), pp. 1266-1281.e7. Date of Electronic Publication: 2023 Jun 13.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Autophagy*/genetics
Lipid Droplets*/metabolism
Animals ; Humans ; Mice ; Autophagosomes/metabolism ; Autophagy-Related Protein 5/genetics ; Autophagy-Related Protein 5/metabolism ; Microtubule-Associated Proteins/genetics ; Microtubule-Associated Proteins/metabolism
Czasopismo naukowe
Tytuł:
Mammalian ATG8 proteins maintain autophagosomal membrane integrity through ESCRTs.
Autorzy:
Javed R; Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.; Autophagy, Inflammation and Metabolism Center of Biomedical Research Excellence, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Jain A; Faculty of Medicine, University of Oslo, Oslo, Norway.
Duque T; Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.; Autophagy, Inflammation and Metabolism Center of Biomedical Research Excellence, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Hendrix E; Department of Chemistry & Chemical Biology, The University of New Mexico, Albuquerque, NM, USA.
Paddar MA; Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.; Autophagy, Inflammation and Metabolism Center of Biomedical Research Excellence, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Khan S; Department of Physics and Astronomy, The University of New Mexico, Albuquerque, NM, USA.
Claude-Taupin A; Autophagy, Inflammation and Metabolism Center of Biomedical Research Excellence, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Jia J; Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.; Autophagy, Inflammation and Metabolism Center of Biomedical Research Excellence, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Allers L; Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.; Autophagy, Inflammation and Metabolism Center of Biomedical Research Excellence, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Wang F; Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.; Autophagy, Inflammation and Metabolism Center of Biomedical Research Excellence, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Mudd M; Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.; Autophagy, Inflammation and Metabolism Center of Biomedical Research Excellence, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Timmins G; Autophagy, Inflammation and Metabolism Center of Biomedical Research Excellence, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Lidke K; Department of Physics and Astronomy, The University of New Mexico, Albuquerque, NM, USA.
Rusten TE; Faculty of Medicine, University of Oslo, Oslo, Norway.
Akepati PR; Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of New Mexico, Albuquerque, NM, USA.
He Y; Department of Chemistry & Chemical Biology, The University of New Mexico, Albuquerque, NM, USA.
Reggiori F; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Aarhus Institute for Advanced Studies (AIAS), Aarhus University, Aarhus, Denmark.
Eskelinen EL; Institute of Biomedicine, University of Turku, Turku, Finland.
Deretic V; Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.; Autophagy, Inflammation and Metabolism Center of Biomedical Research Excellence, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
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Źródło:
The EMBO journal [EMBO J] 2023 Jul 17; Vol. 42 (14), pp. e112845. Date of Electronic Publication: 2023 Jun 05.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Microtubule-Associated Proteins*/genetics
Microtubule-Associated Proteins*/metabolism
Autophagy*
Animals ; Humans ; Autophagy-Related Protein 8 Family/genetics ; Autophagy-Related Protein 8 Family/metabolism ; Autophagosomes/metabolism ; Endosomal Sorting Complexes Required for Transport/metabolism ; Mammals
Czasopismo naukowe
Tytuł:
miR-30a-3p Regulates Autophagy in the Involution of Mice Mammary Glands.
Autorzy:
Tian L; Faculty of Food Science and Engineering, Kunming University of Science and Technology, Kunming 650500, China.
Guo S; Faculty of Food Science and Engineering, Kunming University of Science and Technology, Kunming 650500, China.
Zhao Z; Faculty of Food Science and Engineering, Kunming University of Science and Technology, Kunming 650500, China.
Chen Y; Faculty of Food Science and Engineering, Kunming University of Science and Technology, Kunming 650500, China.
Wang C; Key Laboratory of Dairy Science of Education Ministry, College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.
Li Q; Key Laboratory of Dairy Science of Education Ministry, College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.
Li Y; School of Medicine, Kunming University of Science and Technology, Kunming 650500, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Sep 20; Vol. 24 (18). Date of Electronic Publication: 2023 Sep 20.
Typ publikacji:
Journal Article
MeSH Terms:
Autophagy*/genetics
MicroRNAs*/genetics
Mammary Glands, Animal*/growth & development
Mammary Glands, Animal*/metabolism
Animals ; Female ; Mice ; Autophagy-Related Protein 5 ; Epithelial Cells ; Lactation/genetics
Czasopismo naukowe
Tytuł:
An ATG12-ATG5-TECPR1 E3-like complex regulates unconventional LC3 lipidation at damaged lysosomes.
Autorzy:
Corkery DP; Department of Chemistry, Umeå University, Umeå, Sweden.; Umeå Centre for Microbial Research, Umeå University, Umeå, Sweden.
Castro-Gonzalez S; Department of Chemistry, Umeå University, Umeå, Sweden.; Umeå Centre for Microbial Research, Umeå University, Umeå, Sweden.
Knyazeva A; Department of Chemistry, Umeå University, Umeå, Sweden.; Umeå Centre for Microbial Research, Umeå University, Umeå, Sweden.
Herzog LK; Department of Chemistry, Umeå University, Umeå, Sweden.; Umeå Centre for Microbial Research, Umeå University, Umeå, Sweden.
Wu YW; Department of Chemistry, Umeå University, Umeå, Sweden.; Umeå Centre for Microbial Research, Umeå University, Umeå, Sweden.
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Źródło:
EMBO reports [EMBO Rep] 2023 Sep 06; Vol. 24 (9), pp. e56841. Date of Electronic Publication: 2023 Jun 29.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Microtubule-Associated Proteins*/metabolism
Autophagy*
Macroautophagy ; Galectins/metabolism ; Lysosomes/metabolism ; Autophagy-Related Proteins/metabolism
Czasopismo naukowe
Tytuł:
Regulation of self-renewal in ovarian cancer stem cells by fructose via chaperone-mediated autophagy.
Autorzy:
Sohn EJ; College of Medicine, Pusan National University, Yangsan, Republic of Korea.; Inje University, 197 Injero, Gimhae 50834, Republic of Korea. Electronic address: .
Kim JH; Department of Physiology, School of Medicine, Pusan National University, Yangsan, Republic of Korea.
Oh SO; Department of Anatomy, School of Medicine, Yangsan, Republic of Korea.
Kim JY; The School of Korean Medicine Pusan National University, Yangsan 50612, Republic of Korea.
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Źródło:
Biochimica et biophysica acta. Molecular basis of disease [Biochim Biophys Acta Mol Basis Dis] 2023 Aug; Vol. 1869 (6), pp. 166723. Date of Electronic Publication: 2023 Apr 21.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Chaperone-Mediated Autophagy*
Ovarian Neoplasms*/genetics
Humans ; Female ; Autophagy/genetics ; Cell Line, Tumor ; Trehalose ; Fructose/pharmacology ; Neoplastic Stem Cells
Czasopismo naukowe
Tytuł:
GATA6 Inhibits Neuronal Autophagy and Ferroptosis in Cerebral ischemia-reperfusion Injury Through a miR-193b/ATG7 axis-dependent Mechanism.
Autorzy:
Fan W; Department of Vascular Surgery, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, 2800 Gongwei Road, Pudong, Shanghai, 201300, P. R. China.; Department of Vascular Surgery, Huashan Hospital of Fudan University, No.12, Mid-Wulumuqi Road, Shanghai, 200040, P.R. China.
Rong J; Department of Vascular Surgery, Suzhou TCM Hospital, Nanjing University of Chinese Medicine, Suzhou215000, Nanjing, P.R. China.
Shi W; Department of Vascular Surgery, Huashan Hospital of Fudan University, No.12, Mid-Wulumuqi Road, Shanghai, 200040, P.R. China.
Liu W; Department of Neurology, Suzhou TCM Hospital, Nanjing University of Chinese Medicine, Suzhou215000, Nanjing, P.R. China.
Wang J; Department of Vascular Surgery, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, 2800 Gongwei Road, Pudong, Shanghai, 201300, P. R. China.
Tan J; Department of Vascular Surgery, Huashan Hospital of Fudan University, No.12, Mid-Wulumuqi Road, Shanghai, 200040, P.R. China.
Yu B; Department of Vascular Surgery, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, 2800 Gongwei Road, Pudong, Shanghai, 201300, P. R. China. .; Department of Vascular Surgery, Huashan Hospital of Fudan University, No.12, Mid-Wulumuqi Road, Shanghai, 200040, P.R. China. .
Tong J; Department of Vascular Surgery, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, 2800 Gongwei Road, Pudong, Shanghai, 201300, P. R. China. .
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Źródło:
Neurochemical research [Neurochem Res] 2023 Aug; Vol. 48 (8), pp. 2552-2567. Date of Electronic Publication: 2023 Apr 15.
Typ publikacji:
Journal Article
MeSH Terms:
Infarction, Middle Cerebral Artery*/metabolism
Infarction, Middle Cerebral Artery*/pathology
MicroRNAs*/analysis
GATA6 Transcription Factor*/metabolism
Autophagy-Related Protein 7*/metabolism
Male ; Animals ; Rats ; Rats, Sprague-Dawley ; Disease Models, Animal ; Brain/metabolism ; Brain/pathology ; Neurons/metabolism ; Neurons/pathology ; Autophagy ; Ferroptosis ; Up-Regulation ; Reperfusion Injury/metabolism ; Gene Regulatory Networks
Czasopismo naukowe
Tytuł:
Activation of autophagy depends on Atg1/Ulk1-mediated phosphorylation and inhibition of the Hsp90 chaperone machinery.
Autorzy:
Backe SJ; Department of Urology, SUNY Upstate Medical University, Syracuse, NY 13210, USA; Upstate Cancer Center, SUNY Upstate Medical University, Syracuse, NY 13210, USA.
Sager RA; Department of Urology, SUNY Upstate Medical University, Syracuse, NY 13210, USA; Upstate Cancer Center, SUNY Upstate Medical University, Syracuse, NY 13210, USA.
Heritz JA; Department of Urology, SUNY Upstate Medical University, Syracuse, NY 13210, USA; Upstate Cancer Center, SUNY Upstate Medical University, Syracuse, NY 13210, USA; Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY 13210, USA.
Wengert LA; Department of Urology, SUNY Upstate Medical University, Syracuse, NY 13210, USA; Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY 13210, USA.
Meluni KA; Department of Urology, SUNY Upstate Medical University, Syracuse, NY 13210, USA; Upstate Cancer Center, SUNY Upstate Medical University, Syracuse, NY 13210, USA.
Aran-Guiu X; Biochemistry and Biomedicine, School of Life Sciences, University of Sussex, Brighton, UK.
Panaretou B; School of Cancer and Pharmaceutical Sciences, Institute of Pharmaceutical Science, King's College London, London SE1 9NQ, UK.
Woodford MR; Department of Urology, SUNY Upstate Medical University, Syracuse, NY 13210, USA; Upstate Cancer Center, SUNY Upstate Medical University, Syracuse, NY 13210, USA; Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY 13210, USA.
Prodromou C; Genome Damage and Stability Centre, University of Sussex, Brighton BN1 9RQ, UK.
Bourboulia D; Department of Urology, SUNY Upstate Medical University, Syracuse, NY 13210, USA; Upstate Cancer Center, SUNY Upstate Medical University, Syracuse, NY 13210, USA; Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY 13210, USA.
Mollapour M; Department of Urology, SUNY Upstate Medical University, Syracuse, NY 13210, USA; Upstate Cancer Center, SUNY Upstate Medical University, Syracuse, NY 13210, USA; Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY 13210, USA. Electronic address: .
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Źródło:
Cell reports [Cell Rep] 2023 Jul 25; Vol. 42 (7), pp. 112807. Date of Electronic Publication: 2023 Jul 14.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Autophagy*/physiology
HSP90 Heat-Shock Proteins*/metabolism
Animals ; Phosphorylation ; Autophagy-Related Protein-1 Homolog/metabolism ; Saccharomyces cerevisiae/metabolism ; Serine/metabolism ; Mammals/metabolism
Czasopismo naukowe
Tytuł:
MAEL facilitates metabolic reprogramming and breast cancer progression by promoting the degradation of citrate synthase and fumarate hydratase via chaperone-mediated autophagy.
Autorzy:
Zhou L; State Key Laboratory of Developmental Biology of Freshwater Fish & Key Laboratory of Protein Chemistry and Developmental Biology of the Ministry of Education, College of Life Science, Hunan Normal University, Changsha, China.; College of Clinical Laboratory, Changsha Medical University, China.
Ou S; State Key Laboratory of Developmental Biology of Freshwater Fish & Key Laboratory of Protein Chemistry and Developmental Biology of the Ministry of Education, College of Life Science, Hunan Normal University, Changsha, China.
Liang T; State Key Laboratory of Developmental Biology of Freshwater Fish & Key Laboratory of Protein Chemistry and Developmental Biology of the Ministry of Education, College of Life Science, Hunan Normal University, Changsha, China.
Li M; State Key Laboratory of Developmental Biology of Freshwater Fish & Key Laboratory of Protein Chemistry and Developmental Biology of the Ministry of Education, College of Life Science, Hunan Normal University, Changsha, China.
Xiao P; State Key Laboratory of Developmental Biology of Freshwater Fish & Key Laboratory of Protein Chemistry and Developmental Biology of the Ministry of Education, College of Life Science, Hunan Normal University, Changsha, China.
Cheng J; State Key Laboratory of Developmental Biology of Freshwater Fish & Key Laboratory of Protein Chemistry and Developmental Biology of the Ministry of Education, College of Life Science, Hunan Normal University, Changsha, China.
Zhou J; State Key Laboratory of Developmental Biology of Freshwater Fish & Key Laboratory of Protein Chemistry and Developmental Biology of the Ministry of Education, College of Life Science, Hunan Normal University, Changsha, China.
Yuan L; Department of General Surgery, The Second Xiangya Hospital, Central South University, Changsha, China.
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Źródło:
The FEBS journal [FEBS J] 2023 Jul; Vol. 290 (14), pp. 3614-3628. Date of Electronic Publication: 2023 Mar 12.
Typ publikacji:
Journal Article
MeSH Terms:
Breast Neoplasms*/genetics
Chaperone-Mediated Autophagy*
Humans ; Female ; Fumarate Hydratase/genetics ; Fumarate Hydratase/metabolism ; Citrate (si)-Synthase/metabolism ; Citric Acid Cycle ; Autophagy
Czasopismo naukowe

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