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Wyświetlanie 61-80 z 179
Tytuł:
Atg7-dependent canonical autophagy regulates the degradation of aquaporin 2 in prolonged hypokalemia.
Autorzy:
Kim WY; Department of Anatomy and Cell Death Disease Research Center, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Nam SA; Department of Anatomy and Cell Death Disease Research Center, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Choi A; Department of Anatomy and Cell Death Disease Research Center, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Kim YM; Department of Anatomy and Cell Death Disease Research Center, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Park SH; Institute of Clinical Medicine Research of Bucheon St. Mary's Hospital, Bucheon, Korea.
Kim HL; Integrative Research Support Center, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Kim H; Division of Nephrology, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Seoul, Korea.
Han KH; Department of Anatomy, Ewha Womans University School of Medicine, Seoul, Korea.
Yang CW; Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Lee MS; Severance Biomedical Science Institute, College of Medicine, Yonsei University, Seoul, Korea.
Kim YK; Department of Anatomy and Cell Death Disease Research Center, College of Medicine, The Catholic University of Korea, Seoul, Korea. .; Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea. .
Kim J; Department of Anatomy and Cell Death Disease Research Center, College of Medicine, The Catholic University of Korea, Seoul, Korea. .
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Źródło:
Scientific reports [Sci Rep] 2019 Feb 28; Vol. 9 (1), pp. 3021. Date of Electronic Publication: 2019 Feb 28.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Aquaporin 2/*metabolism
Autophagy/*physiology
Autophagy-Related Protein 7/*metabolism
Hypokalemia/*metabolism
Animals ; Down-Regulation/physiology ; Kidney/metabolism ; Male ; Mice ; Microtubule-Associated Proteins/metabolism ; Phosphorylation/physiology ; rab GTP-Binding Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Control of the Epithelial-to-Mesenchymal Transition and Cancer Metastasis by Autophagy-Dependent SNAI1 Degradation.
Autorzy:
Zada S; Department of Biochemistry and Convergence Medical Sciences, Institute of Health Sciences, Gyeongsang National University School of Medicine, JinJu 527-27, Korea. .
Hwang JS; Department of Biochemistry and Convergence Medical Sciences, Institute of Health Sciences, Gyeongsang National University School of Medicine, JinJu 527-27, Korea. .
Ahmed M; Department of Biochemistry and Convergence Medical Sciences, Institute of Health Sciences, Gyeongsang National University School of Medicine, JinJu 527-27, Korea. ma7moud_.
Lai TH; Department of Biochemistry and Convergence Medical Sciences, Institute of Health Sciences, Gyeongsang National University School of Medicine, JinJu 527-27, Korea. .
Pham TM; Department of Biochemistry and Convergence Medical Sciences, Institute of Health Sciences, Gyeongsang National University School of Medicine, JinJu 527-27, Korea. .
Kim DR; Department of Biochemistry and Convergence Medical Sciences, Institute of Health Sciences, Gyeongsang National University School of Medicine, JinJu 527-27, Korea. .
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Źródło:
Cells [Cells] 2019 Feb 06; Vol. 8 (2). Date of Electronic Publication: 2019 Feb 06.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Autophagy*
Epithelial-Mesenchymal Transition*
Proteolysis*
Snail Family Transcription Factors/*metabolism
Autophagy-Related Protein 7/metabolism ; Cell Movement ; Cell Nucleus/metabolism ; HeLa Cells ; Humans ; Microtubule-Associated Proteins/metabolism ; Models, Biological ; Neoplasm Invasiveness ; Neoplasm Metastasis ; Neoplasms/metabolism ; Neoplasms/pathology ; Protein Binding ; Sequestosome-1 Protein/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Inactivation of autophagy leads to changes in sebaceous gland morphology and function.
Autorzy:
Rossiter H; Research Division of Biology and Pathobiolgy of the Skin, Medical University of Vienna, Vienna, Austria.
Stübiger G; Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria.
Gröger M; Core Facility Imaging, Medical University of Vienna, Vienna, Austria.
König U; Research Division of Biology and Pathobiolgy of the Skin, Medical University of Vienna, Vienna, Austria.
Gruber F; Research Division of Biology and Pathobiolgy of the Skin, Medical University of Vienna, Vienna, Austria.
Sukseree S; Research Division of Biology and Pathobiolgy of the Skin, Medical University of Vienna, Vienna, Austria.
Mlitz V; Research Division of Biology and Pathobiolgy of the Skin, Medical University of Vienna, Vienna, Austria.
Buchberger M; Research Division of Biology and Pathobiolgy of the Skin, Medical University of Vienna, Vienna, Austria.
Oskolkova O; Department of Vascular Biology and Thrombosis Research, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.
Bochkov V; Department of Vascular Biology and Thrombosis Research, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.
Eckhart L; Research Division of Biology and Pathobiolgy of the Skin, Medical University of Vienna, Vienna, Austria.
Tschachler E; Research Division of Biology and Pathobiolgy of the Skin, Medical University of Vienna, Vienna, Austria.
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Źródło:
Experimental dermatology [Exp Dermatol] 2018 Oct; Vol. 27 (10), pp. 1142-1151. Date of Electronic Publication: 2018 Aug 20.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Autophagy/*genetics
Autophagy-Related Protein 7/*genetics
Sebaceous Glands/*pathology
Sebaceous Glands/*physiopathology
Sebum/*chemistry
Animals ; Autophagosomes ; Cell Proliferation/genetics ; Cholesterol/analysis ; Fatty Acids, Nonesterified/analysis ; Hair ; Male ; Mice ; Phenotype ; Waxes/analysis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Glucocerebrosidase deficiency promotes protein aggregation through dysregulation of extracellular vesicles.
Autorzy:
Thomas RE; Department of Genome Sciences, University of Washington, Seattle, WA, United States of America.
Vincow ES; Department of Genome Sciences, University of Washington, Seattle, WA, United States of America.
Merrihew GE; Department of Genome Sciences, University of Washington, Seattle, WA, United States of America.
MacCoss MJ; Department of Genome Sciences, University of Washington, Seattle, WA, United States of America.
Davis MY; Department of Neurology, University of Washington, Seattle, WA, United States of America.; Department of Neurology, Veterans Affairs Puget Sound Health Care System, Seattle, WA, United States of America.
Pallanck LJ; Department of Genome Sciences, University of Washington, Seattle, WA, United States of America.
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Źródło:
PLoS genetics [PLoS Genet] 2018 Sep 26; Vol. 14 (9), pp. e1007694. Date of Electronic Publication: 2018 Sep 26 (Print Publication: 2018).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Drosophila Proteins/*genetics
Extracellular Vesicles/*pathology
Glucosylceramidase/*deficiency
Parkinson Disease/*pathology
Protein Aggregation, Pathological/*pathology
Animals ; Animals, Genetically Modified ; Autophagy/genetics ; Autophagy-Related Protein 7/genetics ; Disease Models, Animal ; Drosophila ; Female ; Glucosylceramidase/genetics ; Humans ; Male ; Mutation ; Parkinson Disease/genetics ; Protein Aggregation, Pathological/genetics ; Proteomics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Size dependent effects of Gold Nanoparticles in ISO-induced Hyperthyroid Rats.
Autorzy:
Zhang J; Department of Cardiovascular Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Shaanxi Key Laboratory of Molecular Cardiology, Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an, Shaanxi, China.
Xue Y; Department of Cardiovascular Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Shaanxi Key Laboratory of Molecular Cardiology, Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an, Shaanxi, China.
Ni Y; Department of Cardiovascular Medicine, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Ning F; Department of Cardiovascular Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Shaanxi Key Laboratory of Molecular Cardiology, Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an, Shaanxi, China. .
Shang L; School of Chemistry and Biosciences, University of Bradford, Bradford, BD7 1DP, UK. .
Ma A; Department of Cardiovascular Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Shaanxi Key Laboratory of Molecular Cardiology, Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an, Shaanxi, China. .
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Źródło:
Scientific reports [Sci Rep] 2018 Jul 19; Vol. 8 (1), pp. 10960. Date of Electronic Publication: 2018 Jul 19.
Typ publikacji:
Journal Article
MeSH Terms:
Gold/*administration & dosage
Heart Diseases/*prevention & control
Hyperthyroidism/*complications
Isoproterenol/*adverse effects
Administration, Intravenous ; Animals ; Autophagy-Related Protein 7/metabolism ; Caspase 12/metabolism ; Cell Line ; Disease Models, Animal ; Gold/pharmacokinetics ; Hyperthyroidism/chemically induced ; Metal Nanoparticles ; Microscopy, Electron, Transmission ; Particle Size ; Rats
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Autophagy enhances the replication of Peste des petits ruminants virus and inhibits caspase-dependent apoptosis in vitro.
Autorzy:
Yang B; a College of Veterinary Medicine , Northwest A&F University , Yangling , China.
Xue Q; b China Institute of Veterinary Drug Control , Beijing , China.
Qi X; a College of Veterinary Medicine , Northwest A&F University , Yangling , China.
Wang X; a College of Veterinary Medicine , Northwest A&F University , Yangling , China.
Jia P; a College of Veterinary Medicine , Northwest A&F University , Yangling , China.
Chen S; a College of Veterinary Medicine , Northwest A&F University , Yangling , China.
Wang T; a College of Veterinary Medicine , Northwest A&F University , Yangling , China.
Xue T; a College of Veterinary Medicine , Northwest A&F University , Yangling , China.
Wang J; a College of Veterinary Medicine , Northwest A&F University , Yangling , China.
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Źródło:
Virulence [Virulence] 2018; Vol. 9 (1), pp. 1176-1194.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Apoptosis*
Autophagy*
Virus Replication*
Caspases/*metabolism
Epithelial Cells/*virology
Peste-des-petits-ruminants virus/*pathogenicity
Ammonium Chloride/pharmacology ; Androstadienes/pharmacology ; Animals ; Autophagosomes/drug effects ; Autophagy-Related Protein 7/deficiency ; Autophagy-Related Protein 7/genetics ; Beclin-1/deficiency ; Beclin-1/genetics ; Chloroquine/pharmacology ; Endometrium/cytology ; Female ; Goats ; Host-Pathogen Interactions ; Humans ; In Vitro Techniques ; Lysosomes/drug effects ; Lysosomes/physiology ; Nucleoproteins/metabolism ; Peste-des-Petits-Ruminants/virology ; Peste-des-petits-ruminants virus/physiology ; Protein C/metabolism ; Wortmannin
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Autophagy is activated to protect renal tubular epithelial cells against iodinated contrast media‑induced cytotoxicity.
Autorzy:
Liu N; Department of Nephrology, Second Xiangya Hospital of Central South University, Nephrology Institute of Central South University, Center of Kidney Disease and Dialysis In Hunan Province, Changsha, Hunan 410011, P.R. China.
Lei R; Department of Nephrology, Second Xiangya Hospital of Central South University, Nephrology Institute of Central South University, Center of Kidney Disease and Dialysis In Hunan Province, Changsha, Hunan 410011, P.R. China.
Tang MM; Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China.
Cheng W; Department of Nephrology, Second Xiangya Hospital of Central South University, Nephrology Institute of Central South University, Center of Kidney Disease and Dialysis In Hunan Province, Changsha, Hunan 410011, P.R. China.
Luo M; Department of Nephrology, Second Xiangya Hospital of Central South University, Nephrology Institute of Central South University, Center of Kidney Disease and Dialysis In Hunan Province, Changsha, Hunan 410011, P.R. China.
Xu Q; Department of Nephrology, Second Xiangya Hospital of Central South University, Nephrology Institute of Central South University, Center of Kidney Disease and Dialysis In Hunan Province, Changsha, Hunan 410011, P.R. China.
Duan SB; Department of Nephrology, Second Xiangya Hospital of Central South University, Nephrology Institute of Central South University, Center of Kidney Disease and Dialysis In Hunan Province, Changsha, Hunan 410011, P.R. China.
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Źródło:
Molecular medicine reports [Mol Med Rep] 2017 Dec; Vol. 16 (6), pp. 8277-8282. Date of Electronic Publication: 2017 Sep 25.
Typ publikacji:
Journal Article
MeSH Terms:
Autophagy*/drug effects
Contrast Media/*adverse effects
Epithelial Cells/*drug effects
Epithelial Cells/*metabolism
Iodine Compounds/*adverse effects
Kidney Tubules/*cytology
Kidney Tubules/*metabolism
Adenine/analogs & derivatives ; Adenine/pharmacology ; Apoptosis/drug effects ; Apoptosis/genetics ; Autophagy-Related Protein 7/genetics ; Autophagy-Related Protein 7/metabolism ; Cell Survival ; Flow Cytometry ; Gene Expression Regulation ; Humans ; Iohexol/pharmacology ; Kidney Tubules/pathology ; Protective Agents/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Akt2 ablation prolongs life span and improves myocardial contractile function with adaptive cardiac remodeling: role of Sirt1-mediated autophagy regulation.
Autorzy:
Ren J; Department of Cardiology and Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.; Center for Cardiovascular Research and Integrative Medicine, School of Pharmacy, University of Wyoming, Laramie, WY, 82071, USA.
Yang L; Center for Cardiovascular Research and Integrative Medicine, School of Pharmacy, University of Wyoming, Laramie, WY, 82071, USA.; Department of Anesthesiology, Xi'an Children Hospital, Xi'an, 710003, China.
Zhu L; Department of Cardiology and Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Xu X; Center for Cardiovascular Research and Integrative Medicine, School of Pharmacy, University of Wyoming, Laramie, WY, 82071, USA.
Ceylan AF; Center for Cardiovascular Research and Integrative Medicine, School of Pharmacy, University of Wyoming, Laramie, WY, 82071, USA.
Guo W; Department of Animal Sciences, University of Wyoming, Laramie, WY, 82071, USA.
Yang J; Department of Cardiovascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.
Zhang Y; Department of Cardiology and Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.; Center for Cardiovascular Research and Integrative Medicine, School of Pharmacy, University of Wyoming, Laramie, WY, 82071, USA.
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Źródło:
Aging cell [Aging Cell] 2017 Oct; Vol. 16 (5), pp. 976-987. Date of Electronic Publication: 2017 Jul 05.
Typ publikacji:
Journal Article
MeSH Terms:
Autophagy/*genetics
Calcium/*metabolism
Cardiomegaly/*genetics
Longevity/*genetics
Proto-Oncogene Proteins c-akt/*genetics
Sirtuin 1/*genetics
Adaptation, Physiological ; Animals ; Atrial Remodeling/drug effects ; Autophagy/drug effects ; Autophagy-Related Protein 7/genetics ; Autophagy-Related Protein 7/metabolism ; Beclin-1/genetics ; Beclin-1/metabolism ; Cardiomegaly/metabolism ; Cardiomegaly/pathology ; Cardiomegaly/prevention & control ; Forkhead Box Protein O1/genetics ; Forkhead Box Protein O1/metabolism ; Gene Expression Regulation ; Heterocyclic Compounds, 4 or More Rings/pharmacology ; Male ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Mice ; Mice, Knockout ; Microtubule-Associated Proteins/genetics ; Microtubule-Associated Proteins/metabolism ; Mitochondria/metabolism ; Mitochondria/pathology ; Mitochondrial Proteins/genetics ; Mitochondrial Proteins/metabolism ; Myocardial Contraction/drug effects ; Myocardium/metabolism ; Myocardium/pathology ; Phosphorylation ; Protein Kinases/genetics ; Protein Kinases/metabolism ; Proto-Oncogene Proteins c-akt/deficiency ; Sarcoplasmic Reticulum Calcium-Transporting ATPases/genetics ; Sarcoplasmic Reticulum Calcium-Transporting ATPases/metabolism ; Signal Transduction ; Sirolimus/pharmacology ; Sirtuin 1/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Dietary fat may modulate adipose tissue homeostasis through the processes of autophagy and apoptosis.
Autorzy:
Camargo A; Lipids and Atherosclerosis Unit, IMIBIC, Reina Sofia University Hospital, University of Cordoba, Av. Menendez Pidal, s/n, 14004, Córdoba, Spain.; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Córdoba, Spain.
Rangel-Zúñiga OA; Lipids and Atherosclerosis Unit, IMIBIC, Reina Sofia University Hospital, University of Cordoba, Av. Menendez Pidal, s/n, 14004, Córdoba, Spain.; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Córdoba, Spain.
Alcalá-Díaz J; Lipids and Atherosclerosis Unit, IMIBIC, Reina Sofia University Hospital, University of Cordoba, Av. Menendez Pidal, s/n, 14004, Córdoba, Spain.; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Córdoba, Spain.
Gomez-Delgado F; Lipids and Atherosclerosis Unit, IMIBIC, Reina Sofia University Hospital, University of Cordoba, Av. Menendez Pidal, s/n, 14004, Córdoba, Spain.; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Córdoba, Spain.
Delgado-Lista J; Lipids and Atherosclerosis Unit, IMIBIC, Reina Sofia University Hospital, University of Cordoba, Av. Menendez Pidal, s/n, 14004, Córdoba, Spain.; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Córdoba, Spain.
García-Carpintero S; Lipids and Atherosclerosis Unit, IMIBIC, Reina Sofia University Hospital, University of Cordoba, Av. Menendez Pidal, s/n, 14004, Córdoba, Spain.; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Córdoba, Spain.
Marín C; Lipids and Atherosclerosis Unit, IMIBIC, Reina Sofia University Hospital, University of Cordoba, Av. Menendez Pidal, s/n, 14004, Córdoba, Spain.; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Córdoba, Spain.
Almadén Y; Lipids and Atherosclerosis Unit, IMIBIC, Reina Sofia University Hospital, University of Cordoba, Av. Menendez Pidal, s/n, 14004, Córdoba, Spain.; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Córdoba, Spain.
Yubero-Serrano EM; Lipids and Atherosclerosis Unit, IMIBIC, Reina Sofia University Hospital, University of Cordoba, Av. Menendez Pidal, s/n, 14004, Córdoba, Spain.; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Córdoba, Spain.
López-Moreno J; Lipids and Atherosclerosis Unit, IMIBIC, Reina Sofia University Hospital, University of Cordoba, Av. Menendez Pidal, s/n, 14004, Córdoba, Spain.; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Córdoba, Spain.
Tinahones FJ; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Córdoba, Spain.; Endocrinology and Nutrition Service, Hospital Virgen de la Victoria, Malaga, Spain.
Pérez-Martínez P; Lipids and Atherosclerosis Unit, IMIBIC, Reina Sofia University Hospital, University of Cordoba, Av. Menendez Pidal, s/n, 14004, Córdoba, Spain.; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Córdoba, Spain.
Roche HM; UCD Institute of Food and Health, UCD Conway Institute, School of Public Health and Population Sciences, University College Dublin, Dublin, UK.
López-Miranda J; Lipids and Atherosclerosis Unit, IMIBIC, Reina Sofia University Hospital, University of Cordoba, Av. Menendez Pidal, s/n, 14004, Córdoba, Spain. .; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Córdoba, Spain. .
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Źródło:
European journal of nutrition [Eur J Nutr] 2017 Jun; Vol. 56 (4), pp. 1621-1628. Date of Electronic Publication: 2016 Mar 30.
Typ publikacji:
Journal Article; Multicenter Study; Randomized Controlled Trial
MeSH Terms:
Apoptosis*
Autophagy*
Adipocytes/*cytology
Adipose Tissue/*physiopathology
Dietary Fats/*administration & dosage
Adult ; Aged ; Autophagy-Related Protein 7/genetics ; Autophagy-Related Protein 7/metabolism ; Beclin-1/genetics ; Beclin-1/metabolism ; Blood Glucose/metabolism ; Caspase 3/genetics ; Caspase 3/metabolism ; Caspase 7/genetics ; Caspase 7/metabolism ; Diet, Fat-Restricted ; Diet, High-Fat ; Fatty Acids/administration & dosage ; Fatty Acids, Monounsaturated/administration & dosage ; Fatty Acids, Omega-3/administration & dosage ; Female ; Gene Expression Regulation ; Homeostasis ; Humans ; Insulin Resistance ; Male ; Metabolic Syndrome/physiopathology ; Middle Aged ; Obesity/physiopathology ; Single-Blind Method
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Verapamil treatment induces cytoprotective autophagy by modulating cellular metabolism.
Autorzy:
Kania E; Mossakowski Medical Research Centre, Polish Academy of Science, Electron Microscopy Platform, Warsaw, Poland.
Pająk B; Mossakowski Medical Research Centre, Polish Academy of Science, Electron Microscopy Platform, Warsaw, Poland.; Independent Laboratory of Genetics and Molecular Biology, Kaczkowski Military Institute of Hygiene and Epidemiology, Warsaw, Poland.
O'Prey J; Cancer Research UK Beatson Institute, Glasgow, UK.
Sierra Gonzalez P; Cancer Research UK Beatson Institute, Glasgow, UK.
Litwiniuk A; Department of Neuroendocrinology, Centre of Postgraduate Medical Education, Warsaw, Poland.
Urbańska K; Warsaw University of Life Sciences - SGGW, Poland.
Ryan KM; Cancer Research UK Beatson Institute, Glasgow, UK.
Orzechowski A; Mossakowski Medical Research Centre, Polish Academy of Science, Electron Microscopy Platform, Warsaw, Poland.; Warsaw University of Life Sciences - SGGW, Poland.
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Źródło:
The FEBS journal [FEBS J] 2017 May; Vol. 284 (9), pp. 1370-1387. Date of Electronic Publication: 2017 Apr 18.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents/*pharmacology
Autophagy/*drug effects
Calcium Channel Blockers/*pharmacology
Cytoprotection/*drug effects
Glycolysis/*drug effects
Neoplasms/*drug therapy
Verapamil/*pharmacology
Antimalarials/pharmacology ; Antineoplastic Agents/adverse effects ; Autophagosomes/drug effects ; Autophagosomes/metabolism ; Autophagosomes/ultrastructure ; Autophagy-Related Protein 5/antagonists & inhibitors ; Autophagy-Related Protein 5/genetics ; Autophagy-Related Protein 5/metabolism ; Autophagy-Related Protein 7/antagonists & inhibitors ; Autophagy-Related Protein 7/genetics ; Autophagy-Related Protein 7/metabolism ; Biomarkers/metabolism ; CRISPR-Cas Systems ; Calcium Channel Blockers/adverse effects ; Cell Line, Transformed ; Cell Line, Tumor ; Cell Survival/drug effects ; Cells, Cultured ; Chloroquine/pharmacology ; Energy Metabolism/drug effects ; Humans ; Isoenzymes/antagonists & inhibitors ; Isoenzymes/metabolism ; L-Lactate Dehydrogenase/antagonists & inhibitors ; L-Lactate Dehydrogenase/metabolism ; Lactate Dehydrogenase 5 ; Microscopy, Electron, Transmission ; Neoplasms/metabolism ; Neoplasms/ultrastructure ; Verapamil/adverse effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Chronic activation of PPARα with fenofibrate reduces autophagic proteins in the liver of mice independent of FGF21.
Autorzy:
Jo E; School of Health and Biomedical Sciences, RMIT University, Melbourne, Victoria, Australia.
Li S; School of Health and Biomedical Sciences, RMIT University, Melbourne, Victoria, Australia.
Liang Q; State Key Laboratory of Pharmaceutical Biotechnology, Department of Medicine, Hong Kong University, Hong Kong, China.
Zhang X; School of Health and Biomedical Sciences, RMIT University, Melbourne, Victoria, Australia.
Wang H; School of Health and Biomedical Sciences, RMIT University, Melbourne, Victoria, Australia.
Herbert TP; School of Health and Biomedical Sciences, RMIT University, Melbourne, Victoria, Australia.
Jenkins TA; School of Health and Biomedical Sciences, RMIT University, Melbourne, Victoria, Australia.
Xu A; State Key Laboratory of Pharmaceutical Biotechnology, Department of Medicine, Hong Kong University, Hong Kong, China.
Ye JM; School of Health and Biomedical Sciences, RMIT University, Melbourne, Victoria, Australia.
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Źródło:
PloS one [PLoS One] 2017 Apr 19; Vol. 12 (4), pp. e0173676. Date of Electronic Publication: 2017 Apr 19 (Print Publication: 2017).
Typ publikacji:
Journal Article
MeSH Terms:
Autophagy/*drug effects
Fenofibrate/*pharmacology
Gene Expression Regulation/*drug effects
Liver/*drug effects
PPAR alpha/*agonists
Animals ; Autophagy/genetics ; Autophagy-Related Protein 5/antagonists & inhibitors ; Autophagy-Related Protein 5/genetics ; Autophagy-Related Protein 5/metabolism ; Autophagy-Related Protein 7/antagonists & inhibitors ; Autophagy-Related Protein 7/genetics ; Autophagy-Related Protein 7/metabolism ; Autophagy-Related Proteins/antagonists & inhibitors ; Autophagy-Related Proteins/genetics ; Autophagy-Related Proteins/metabolism ; Beclin-1/genetics ; Beclin-1/metabolism ; Blood Glucose/metabolism ; Cysteine Endopeptidases/genetics ; Cysteine Endopeptidases/metabolism ; Fibroblast Growth Factors/genetics ; Fibroblast Growth Factors/metabolism ; Forkhead Box Protein O1/genetics ; Forkhead Box Protein O1/metabolism ; Liver/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Microtubule-Associated Proteins/genetics ; Microtubule-Associated Proteins/metabolism ; PPAR alpha/genetics ; PPAR alpha/metabolism ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; Sequestosome-1 Protein/genetics ; Sequestosome-1 Protein/metabolism ; Signal Transduction ; Stearoyl-CoA Desaturase/genetics ; Stearoyl-CoA Desaturase/metabolism ; Sterol Regulatory Element Binding Protein 1/genetics ; Sterol Regulatory Element Binding Protein 1/metabolism ; TOR Serine-Threonine Kinases/genetics ; TOR Serine-Threonine Kinases/metabolism ; Triglycerides/metabolism ; Ubiquitin-Conjugating Enzymes/antagonists & inhibitors ; Ubiquitin-Conjugating Enzymes/genetics ; Ubiquitin-Conjugating Enzymes/metabolism ; fas Receptor/genetics ; fas Receptor/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Pre-incubation with hucMSC-exosomes prevents cisplatin-induced nephrotoxicity by activating autophagy.
Autorzy:
Wang B; Key Laboratory of Laboratory Medicine of Jiangsu Province, School of Medicine, Jiangsu University, 301 Xuefu Road, Zhenjiang, Jiangsu, 212013, People's Republic of China.; The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People's Republic of China.
Jia H; Key Laboratory of Laboratory Medicine of Jiangsu Province, School of Medicine, Jiangsu University, 301 Xuefu Road, Zhenjiang, Jiangsu, 212013, People's Republic of China.
Zhang B; Key Laboratory of Laboratory Medicine of Jiangsu Province, School of Medicine, Jiangsu University, 301 Xuefu Road, Zhenjiang, Jiangsu, 212013, People's Republic of China.
Wang J; Key Laboratory of Laboratory Medicine of Jiangsu Province, School of Medicine, Jiangsu University, 301 Xuefu Road, Zhenjiang, Jiangsu, 212013, People's Republic of China.
Ji C; Key Laboratory of Laboratory Medicine of Jiangsu Province, School of Medicine, Jiangsu University, 301 Xuefu Road, Zhenjiang, Jiangsu, 212013, People's Republic of China.
Zhu X; The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People's Republic of China.
Yan Y; Key Laboratory of Laboratory Medicine of Jiangsu Province, School of Medicine, Jiangsu University, 301 Xuefu Road, Zhenjiang, Jiangsu, 212013, People's Republic of China.
Yin L; Key Laboratory of Laboratory Medicine of Jiangsu Province, School of Medicine, Jiangsu University, 301 Xuefu Road, Zhenjiang, Jiangsu, 212013, People's Republic of China.
Yu J; Key Laboratory of Laboratory Medicine of Jiangsu Province, School of Medicine, Jiangsu University, 301 Xuefu Road, Zhenjiang, Jiangsu, 212013, People's Republic of China.
Qian H; Key Laboratory of Laboratory Medicine of Jiangsu Province, School of Medicine, Jiangsu University, 301 Xuefu Road, Zhenjiang, Jiangsu, 212013, People's Republic of China. .
Xu W; Key Laboratory of Laboratory Medicine of Jiangsu Province, School of Medicine, Jiangsu University, 301 Xuefu Road, Zhenjiang, Jiangsu, 212013, People's Republic of China. .
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Źródło:
Stem cell research & therapy [Stem Cell Res Ther] 2017 Apr 08; Vol. 8 (1), pp. 75. Date of Electronic Publication: 2017 Apr 08.
Typ publikacji:
Journal Article
MeSH Terms:
Adenine/*analogs & derivatives
Autophagy/*drug effects
Cisplatin/*antagonists & inhibitors
Exosomes/*transplantation
Mesenchymal Stem Cells/*cytology
Nephritis/*therapy
Adenine/pharmacology ; Animals ; Autophagy-Related Protein 5/genetics ; Autophagy-Related Protein 5/metabolism ; Autophagy-Related Protein 7/genetics ; Autophagy-Related Protein 7/metabolism ; Biomarkers/metabolism ; Cell Differentiation ; Cell Line ; Cisplatin/toxicity ; Epithelial Cells/cytology ; Epithelial Cells/drug effects ; Epithelial Cells/metabolism ; Exosomes/chemistry ; Female ; Fetus ; Fibroblasts/cytology ; Fibroblasts/drug effects ; Fibroblasts/metabolism ; Gene Expression ; Humans ; Mesenchymal Stem Cells/drug effects ; Mesenchymal Stem Cells/metabolism ; Microtubule-Associated Proteins/genetics ; Microtubule-Associated Proteins/metabolism ; Nephritis/chemically induced ; Nephritis/genetics ; Nephritis/pathology ; Primary Cell Culture ; Rats ; Rats, Sprague-Dawley ; Sirolimus/pharmacology ; Umbilical Cord/cytology ; Umbilical Cord/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Progranulin causes adipose insulin resistance via increased autophagy resulting from activated oxidative stress and endoplasmic reticulum stress.
Autorzy:
Guo Q; Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, 277 Yanta West Road, Xi'an, Shaanxi, 710061, China.
Xu L; Department of Endocrinology, the Affiliated Guangren Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710004, China.
Li H; Key Laboratory of Environment and Genes Related to Diseases, Medical School of Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, China.
Sun H; Key Laboratory of Environment and Genes Related to Diseases, Medical School of Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, China.
Liu J; Clinical Laboratory, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, China.
Wu S; Center for Translational Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, China.
Zhou B; Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, 277 Yanta West Road, Xi'an, Shaanxi, 710061, China. zb_.
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Źródło:
Lipids in health and disease [Lipids Health Dis] 2017 Jan 31; Vol. 16 (1), pp. 25. Date of Electronic Publication: 2017 Jan 31.
Typ publikacji:
Journal Article; Retracted Publication
MeSH Terms:
Adipose Tissue/*drug effects
Endoplasmic Reticulum Stress/*drug effects
Intercellular Signaling Peptides and Proteins/*pharmacology
Nitric Oxide/*agonists
Reactive Oxygen Species/*agonists
3T3-L1 Cells ; Adipose Tissue/metabolism ; Adipose Tissue/pathology ; Animals ; Autophagy/drug effects ; Autophagy-Related Protein 7/genetics ; Autophagy-Related Protein 7/metabolism ; Endoplasmic Reticulum Chaperone BiP ; Gene Expression Regulation ; Glucose/metabolism ; Granulins ; Heat-Shock Proteins/genetics ; Heat-Shock Proteins/metabolism ; Injections, Intraperitoneal ; Insulin Receptor Substrate Proteins/genetics ; Insulin Receptor Substrate Proteins/metabolism ; Insulin Resistance ; Male ; Mice ; Mice, Inbred C57BL ; Microtubule-Associated Proteins/genetics ; Microtubule-Associated Proteins/metabolism ; Nitric Oxide/metabolism ; Nitric Oxide Synthase Type II/genetics ; Nitric Oxide Synthase Type II/metabolism ; Oxidative Stress/drug effects ; Phenylbutyrates/pharmacology ; Progranulins ; Reactive Oxygen Species/metabolism ; Sequestosome-1 Protein/genetics ; Sequestosome-1 Protein/metabolism ; Signal Transduction ; Transcription Factor CHOP/genetics ; Transcription Factor CHOP/metabolism ; eIF-2 Kinase/genetics ; eIF-2 Kinase/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Adipocyte Fatty Acid Binding Protein Potentiates Toxic Lipids-Induced Endoplasmic Reticulum Stress in Macrophages via Inhibition of Janus Kinase 2-dependent Autophagy.
Autorzy:
Hoo RL; State Key Laboratory of Pharmaceutical Biotechnology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.; Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Shu L; State Key Laboratory of Pharmaceutical Biotechnology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.; Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Cheng KK; State Key Laboratory of Pharmaceutical Biotechnology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.; Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Wu X; State Key Laboratory of Pharmaceutical Biotechnology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.; Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Liao B; State Key Laboratory of Pharmaceutical Biotechnology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.; Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Wu D; Key laboratory of Regenerative Biology, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.
Zhou Z; Department of Geriatrics, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Xu A; State Key Laboratory of Pharmaceutical Biotechnology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.; Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.; Department of Pharmacology and Pharmacy, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
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Źródło:
Scientific reports [Sci Rep] 2017 Jan 17; Vol. 7, pp. 40657. Date of Electronic Publication: 2017 Jan 17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Autophagy*
Endoplasmic Reticulum Stress*/drug effects
Lipid Metabolism*
Adipocytes/*metabolism
Fatty Acid-Binding Proteins/*metabolism
Janus Kinase 2/*metabolism
Macrophages/*metabolism
Animals ; Autophagy-Related Protein 7/genetics ; Autophagy-Related Protein 7/metabolism ; Fatty Acid-Binding Proteins/genetics ; Macrophage Activation ; Mice ; Models, Biological ; Palmitic Acid/pharmacology ; Phagocytosis ; RAW 264.7 Cells ; Signal Transduction/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Loss of Atg16 delays the alcohol-induced sedation response via regulation of Corazonin neuropeptide production in Drosophila.
Autorzy:
Varga K; Department of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, Pázmány s. 1/C, Budapest, H-1117 Hungary.; Institute of Genetics, Biological Research Centre, Hungarian Academy of Sciences, Temesvári krt. 62, Szeged, H-6726 Hungary.
Nagy P; Department of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, Pázmány s. 1/C, Budapest, H-1117 Hungary.
Arsikin Csordás K; Department of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, Pázmány s. 1/C, Budapest, H-1117 Hungary.
Kovács AL; Department of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, Pázmány s. 1/C, Budapest, H-1117 Hungary.
Hegedűs K; Department of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, Pázmány s. 1/C, Budapest, H-1117 Hungary.
Juhász G; Department of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, Pázmány s. 1/C, Budapest, H-1117 Hungary.; Institute of Genetics, Biological Research Centre, Hungarian Academy of Sciences, Temesvári krt. 62, Szeged, H-6726 Hungary.
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Źródło:
Scientific reports [Sci Rep] 2016 Oct 06; Vol. 6, pp. 34641. Date of Electronic Publication: 2016 Oct 06.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Autophagy/*genetics
Autophagy-Related Proteins/*genetics
Drosophila Proteins/*genetics
Drosophila melanogaster/*drug effects
Ethanol/*pharmacology
Neuropeptides/*genetics
Neurosecretory Systems/*drug effects
Animals ; Animals, Genetically Modified ; Autophagy-Related Protein 7/deficiency ; Autophagy-Related Protein 7/genetics ; Autophagy-Related Proteins/deficiency ; Brain/cytology ; Brain/drug effects ; Brain/metabolism ; Drosophila Proteins/deficiency ; Drosophila Proteins/metabolism ; Drosophila melanogaster/genetics ; Drosophila melanogaster/metabolism ; Gene Deletion ; Gene Expression Regulation ; Hypnotics and Sedatives/pharmacology ; Neuropeptides/metabolism ; Neurosecretory Systems/cytology ; Neurosecretory Systems/metabolism ; Protein Isoforms/deficiency ; Protein Isoforms/genetics ; Signal Transduction ; Time Factors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Metabolomic Analysis of Mouse Embryonic Fibroblast Cells in Response to Autophagy Induced by Acute Starvation.
Autorzy:
Shen S; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Institute of Analytical Chemistry, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China.
Weng R; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Institute of Analytical Chemistry, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China.; Institute of Quality Standard and Testing Technology for Agro-Products, Chinese Academy of Agricultural Sciences, Beijing, 100081, China.
Li L; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Institute of Analytical Chemistry, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China.
Xu X; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Institute of Analytical Chemistry, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China.
Bai Y; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Institute of Analytical Chemistry, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China.
Liu H; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Institute of Analytical Chemistry, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China.
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Źródło:
Scientific reports [Sci Rep] 2016 Oct 05; Vol. 6, pp. 34075. Date of Electronic Publication: 2016 Oct 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Autophagy*
Metabolome*
Embryo, Mammalian/*metabolism
Fibroblasts/*metabolism
Animals ; Autophagy-Related Protein 7/deficiency ; Autophagy-Related Protein 7/metabolism ; Cell Line ; Embryo, Mammalian/cytology ; Fibroblasts/cytology ; Metabolomics ; Mice ; Mice, Knockout
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Autophagy-Associated Protein SmATG12 Is Required for Fruiting-Body Formation in the Filamentous Ascomycete Sordaria macrospora.
Autorzy:
Werner A; Institute of Microbiology and Genetics, Department of Genetics of Eukaryotic Microorganisms, Georg-August University, Göttingen, Germany.
Herzog B; Institute of Microbiology and Genetics, Department of Genetics of Eukaryotic Microorganisms, Georg-August University, Göttingen, Germany.
Frey S; Institute of Microbiology and Genetics, Department of Genetics of Eukaryotic Microorganisms, Georg-August University, Göttingen, Germany.
Pöggeler S; Institute of Microbiology and Genetics, Department of Genetics of Eukaryotic Microorganisms, Georg-August University, Göttingen, Germany.; Göttingen Center for Molecular Biosciences (GZMB), Georg-August University, Göttingen, Germany.
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Źródło:
PloS one [PLoS One] 2016 Jun 16; Vol. 11 (6), pp. e0157960. Date of Electronic Publication: 2016 Jun 16 (Print Publication: 2016).
Typ publikacji:
Journal Article
MeSH Terms:
Gene Expression Regulation, Fungal*
Autophagy/*genetics
Autophagy-Related Protein 12/*genetics
Fruiting Bodies, Fungal/*genetics
Fungal Proteins/*genetics
Sordariales/*genetics
Amino Acid Sequence ; Autophagy-Related Protein 12/metabolism ; Autophagy-Related Protein 7/genetics ; Autophagy-Related Protein 7/metabolism ; Autophagy-Related Protein 8 Family/genetics ; Autophagy-Related Protein 8 Family/metabolism ; Cloning, Molecular ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Fruiting Bodies, Fungal/growth & development ; Fruiting Bodies, Fungal/metabolism ; Fruiting Bodies, Fungal/ultrastructure ; Fungal Proteins/metabolism ; Hyphae/genetics ; Hyphae/growth & development ; Hyphae/metabolism ; Hyphae/ultrastructure ; Open Reading Frames ; Phagosomes/metabolism ; Phagosomes/ultrastructure ; Protein Binding ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Sequence Alignment ; Sequence Homology, Amino Acid ; Sordariales/growth & development ; Sordariales/metabolism ; Sordariales/ultrastructure ; Two-Hybrid System Techniques ; Vacuoles/metabolism ; Vacuoles/ultrastructure
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
TOR signaling pathway and autophagy are involved in the regulation of circadian rhythms in behavior and plasticity of L2 interneurons in the brain of Drosophila melanogaster.
Autorzy:
Kijak E; Department of Cell Biology and Imaging, Institute of Zoology, Jagiellonian University, Kraków, Poland.
Pyza E; Department of Cell Biology and Imaging, Institute of Zoology, Jagiellonian University, Kraków, Poland.
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Źródło:
PloS one [PLoS One] 2017 Feb 14; Vol. 12 (2), pp. e0171848. Date of Electronic Publication: 2017 Feb 14 (Print Publication: 2017).
Typ publikacji:
Journal Article
MeSH Terms:
Autophagy/*genetics
Brain/*metabolism
Drosophila Proteins/*genetics
Drosophila melanogaster/*genetics
Interneurons/*metabolism
TOR Serine-Threonine Kinases/*genetics
Animals ; Animals, Genetically Modified ; Autophagy-Related Protein 7/genetics ; Brain/cytology ; Circadian Rhythm/genetics ; Circadian Rhythm/physiology ; Drosophila melanogaster/physiology ; Gene Expression ; Male ; Microscopy, Confocal ; Motor Activity/genetics ; Motor Activity/physiology ; Neuronal Plasticity/genetics ; Neuronal Plasticity/physiology ; Phosphatidylinositol 3-Kinases/genetics ; Proto-Oncogene Proteins c-akt/genetics ; RNA Interference ; Reverse Transcriptase Polymerase Chain Reaction ; Signal Transduction/genetics ; Signal Transduction/physiology ; Sleep/genetics ; Sleep/physiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Co-Targeting IGF-1R and Autophagy Enhances the Effects of Cell Growth Suppression and Apoptosis Induced by the IGF-1R Inhibitor NVP-AEW541 in Triple-Negative Breast Cancer Cells.
Autorzy:
Wu W; Department of Breast Surgery, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.; Department of Vascular Surgery, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Ma J; Laboratory of General Surgery, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Shao N; Department of Breast Surgery, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Shi Y; Department of Breast Surgery, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Liu R; Laboratory of General Surgery, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Li W; Department of Vascular Surgery, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Lin Y; Department of Breast Surgery, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Wang S; Department of Breast Surgery, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.; Department of Vascular Surgery, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
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Źródło:
PloS one [PLoS One] 2017 Jan 03; Vol. 12 (1), pp. e0169229. Date of Electronic Publication: 2017 Jan 03 (Print Publication: 2017).
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis/*drug effects
Autophagy/*drug effects
Pyrimidines/*pharmacology
Pyrroles/*pharmacology
Receptor, IGF Type 1/*antagonists & inhibitors
Triple Negative Breast Neoplasms/*metabolism
Triple Negative Breast Neoplasms/*pathology
Adenine/analogs & derivatives ; Adenine/pharmacology ; Autophagy-Related Protein 7/metabolism ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Female ; G1 Phase Cell Cycle Checkpoints/drug effects ; Humans ; Proto-Oncogene Proteins c-akt/metabolism ; RNA, Small Interfering/metabolism ; Receptor, IGF Type 1/metabolism ; Signal Transduction/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 61-80 z 179

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