Temat: "Autophagy-Related Protein-1 Homolog" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Endurance Exercise Training Mitigates Diastolic Dysfunction in Diabetic Mice Independent of Phosphorylation of Ulk1 at S555.
Autorzy:: Guan Y; Fralin Biomedical Research Institute, Center for Exercise Medicine Research at Virginia Tech Carilion, Roanoke, VA 24016, USA.; Center for Skeletal Muscle Research at Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22903, USA.; Departments of Pharmacology, School of Medicine, University of Virginia, Charlottesville, VA 22903, USA.
Zhang M; Fralin Biomedical Research Institute, Center for Exercise Medicine Research at Virginia Tech Carilion, Roanoke, VA 24016, USA.; Center for Skeletal Muscle Research at Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22903, USA.; Departments of Medicine, School of Medicine, University of Virginia, Charlottesville, VA 22903, USA.
Lacy C; Fralin Biomedical Research Institute, Center for Exercise Medicine Research at Virginia Tech Carilion, Roanoke, VA 24016, USA.
Shah S; Departments of Biomedical Engineering, School of Medicine, University of Virginia, Charlottesville, VA 22903, USA.
Epstein FH; Departments of Biomedical Engineering, School of Medicine, University of Virginia, Charlottesville, VA 22903, USA.
Yan Z; Fralin Biomedical Research Institute, Center for Exercise Medicine Research at Virginia Tech Carilion, Roanoke, VA 24016, USA.; Center for Skeletal Muscle Research at Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22903, USA.; Departments of Pharmacology, School of Medicine, University of Virginia, Charlottesville, VA 22903, USA.; Departments of Medicine, School of Medicine, University of Virginia, Charlottesville, VA 22903, USA.; Departments of Biomedical Engineering, School of Medicine, University of Virginia, Charlottesville, VA 22903, USA.; Departments of Molecular Physiology and Biological Physics, School of Medicine, University of Virginia, Charlottesville, VA 22903, USA.; Department of Human Nutrition, Foods, and Exercise, College of Agriculture and Life Sciences, Virginia Tech, Blacksburg, VA 24061, USA.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2024 Jan 03; Vol. 25 (1). Date of Electronic Publication: 2024 Jan 03.
Typ publikacji:: Journal Article
MeSH Terms:: Diabetes Mellitus, Experimental*/complications
Diabetes Mellitus, Experimental*/therapy
Physical Conditioning, Animal*
Autophagy-Related Protein-1 Homolog*/genetics
Animals ; Mice ; Exercise Therapy ; Motor Activity ; Phosphorylation ; Diastole

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Skocz do pozycji: 2.

Tytuł:: Imeglimin Exhibits Novel Anti-Inflammatory Effects on High-Glucose-Stimulated Mouse Microglia through ULK1-Mediated Suppression of the TXNIP-NLRP3 Axis.
Autorzy:: Kato H; Department of Endocrinology, Metabolism and Hypertension Research, Clinical Research Institute, NHO Kyoto Medical Center, Kyoto 612-8555, Japan.
Iwashita K; Department of Endocrinology, Metabolism and Hypertension Research, Clinical Research Institute, NHO Kyoto Medical Center, Kyoto 612-8555, Japan.
Iwasa M; Department of Endocrinology, Metabolism and Hypertension Research, Clinical Research Institute, NHO Kyoto Medical Center, Kyoto 612-8555, Japan.
Kato S; Department of Endocrinology, Metabolism and Hypertension Research, Clinical Research Institute, NHO Kyoto Medical Center, Kyoto 612-8555, Japan.; Department of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan.
Yamakage H; Department of Endocrinology, Metabolism and Hypertension Research, Clinical Research Institute, NHO Kyoto Medical Center, Kyoto 612-8555, Japan.
Suganami T; Department of Molecular Medicine and Metabolism, Research Institute of Environmental Medicine, Nagoya University, Nagoya 464-8601, Japan.; Department of Immunometabolism, Nagoya University Graduate School of Medicine, Nagoya 464-8601, Japan.; Institute of Nano-Life-Systems, Institutes of Innovation for Future Society, Nagoya University, Nagoya 464-8601, Japan.; Center for One Medicine Innovative Translational Research (COMIT), Nagoya University, Nagoya 464-8601, Japan.
Tanaka M; Department of Endocrinology, Metabolism and Hypertension Research, Clinical Research Institute, NHO Kyoto Medical Center, Kyoto 612-8555, Japan.; Department of Rehabilitation, Health Science University, Minamitsuru-gun 401-0380, Japan.
Satoh-Asahara N; Department of Endocrinology, Metabolism and Hypertension Research, Clinical Research Institute, NHO Kyoto Medical Center, Kyoto 612-8555, Japan.; Department of Metabolic Syndrome and Nutritional Science, Research Institute of Environmental Medicine, Nagoya University, Nagoya 466-8550, Japan.; Pokaż więcej
Źródło:: Cells [Cells] 2024 Feb 05; Vol. 13 (3). Date of Electronic Publication: 2024 Feb 05.
Typ publikacji:: Journal Article
MeSH Terms:: Diabetes Mellitus, Type 2*/complications
Diabetes Mellitus, Type 2*/drug therapy
Triazines*
Animals ; Mice ; Anti-Inflammatory Agents/pharmacology ; Glucose/pharmacology ; Microglia/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Reactive Oxygen Species/metabolism ; Autophagy-Related Protein-1 Homolog/drug effects ; Autophagy-Related Protein-1 Homolog/metabolism ; Thioredoxins/drug effects ; Thioredoxins/metabolism

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Skocz do pozycji: 3.

Tytuł:: AFF4 regulates osteogenic potential of human periodontal ligament stem cells via mTOR-ULK1-autophagy axis.
Autorzy:: Zhu L; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Wang J; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Wu Z; Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou, China.
Chen S; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
He Y; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Jiang Y; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Luo G; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Wu Z; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Li Y; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Xie J; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Zou S; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.; Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Zhou C; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.; Department of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, China.; Pokaż więcej
Źródło:: Cell proliferation [Cell Prolif] 2024 Feb; Vol. 57 (2), pp. e13546. Date of Electronic Publication: 2023 Sep 20.
Typ publikacji:: Journal Article
MeSH Terms:: Osteogenesis*
Periodontal Ligament*
Humans ; Autophagy-Related Protein-1 Homolog ; Cell Differentiation ; Cells, Cultured ; Intracellular Signaling Peptides and Proteins ; Sirolimus/pharmacology ; Stem Cells ; TOR Serine-Threonine Kinases ; Transcription Factors ; Transcriptional Elongation Factors

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Skocz do pozycji: 4.

Tytuł:: Exosomal circHIPK3 derived from umbilical cord-derived mesenchymal stem cells enhances skin fibroblast autophagy by blocking miR-20b-5p/ULK1/Atg13 axis.
Autorzy:: Qiu ZY; Department of Burn & Skin Repair Surgery, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou, Hainan, China.
Lin SS; Department of Burn & Skin Repair Surgery, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou, Hainan, China.
Pan NF; Department of Burn & Skin Repair Surgery, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou, Hainan, China.
Lin ZH; Department of Burn & Skin Repair Surgery, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou, Hainan, China.
Pan YC; Department of Burn & Skin Repair Surgery, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou, Hainan, China.
Liang ZH; Department of Burn & Skin Repair Surgery, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou, Hainan, China.; Pokaż więcej
Źródło:: Journal of diabetes investigation [J Diabetes Investig] 2023 Dec; Vol. 14 (12), pp. 1344-1355. Date of Electronic Publication: 2023 Sep 08.
Typ publikacji:: Journal Article
MeSH Terms:: MicroRNAs*/genetics
MicroRNAs*/metabolism
Mesenchymal Stem Cells*
Humans ; Transcription Factors ; Autophagy ; Fibroblasts ; Glucose ; Autophagy-Related Protein-1 Homolog/genetics ; Autophagy-Related Protein-1 Homolog/metabolism ; Intracellular Signaling Peptides and Proteins/genetics

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Skocz do pozycji: 5.

Tytuł:: Qiangjing tablets ameliorate asthenozoospermia via mitochondrial ubiquitination and mitophagy mediated by LKB1/AMPK/ULK1 signaling.
Autorzy:: Li G; Department of Urology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Xu Y; Department of Urology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Li Y; Department of Urology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Chang D; Department of Urology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Zhang P; Department of Urology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Ma Z; Department of Urology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Chen D; Department of Urology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
You Y; Department of Urology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Huang X; Department of Urology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Cai J; Department of Urology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.; Pokaż więcej
Źródło:: Pharmaceutical biology [Pharm Biol] 2023 Dec; Vol. 61 (1), pp. 271-280.
Typ publikacji:: Journal Article
MeSH Terms:: Asthenozoospermia*/drug therapy
Drugs, Chinese Herbal*/therapeutic use
Animals ; Male ; Rats ; AMP-Activated Protein Kinases ; Autophagy-Related Protein-1 Homolog ; Intracellular Signaling Peptides and Proteins/pharmacology ; Intracellular Signaling Peptides and Proteins/therapeutic use ; Mitophagy ; Rats, Sprague-Dawley ; Semen ; Sperm Motility ; Tablets/therapeutic use ; Ubiquitination

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Skocz do pozycji: 6.

Tytuł:: Decrease in α-Globin and Increase in the Autophagy-Activating Kinase ULK1 mRNA in Erythroid Precursors from β-Thalassemia Patients Treated with Sirolimus.
Autorzy:: Zurlo M; Department of Life Sciences and Biotechnology, Ferrara University, 44121 Ferrara, Italy.
Zuccato C; Department of Life Sciences and Biotechnology, Ferrara University, 44121 Ferrara, Italy.; Center 'Chiara Gemmo and Elio Zago' for the Research on Thalassemia, Ferrara University, 44121 Ferrara, Italy.
Cosenza LC; Department of Life Sciences and Biotechnology, Ferrara University, 44121 Ferrara, Italy.
Gasparello J; Department of Life Sciences and Biotechnology, Ferrara University, 44121 Ferrara, Italy.
Gamberini MR; Thalassemia Unit, Arcispedale S. Anna, 44121 Ferrara, Italy.
Stievano A; Thalassemia Unit, Arcispedale S. Anna, 44121 Ferrara, Italy.
Fortini M; Thalassemia Unit, Arcispedale S. Anna, 44121 Ferrara, Italy.
Prosdocimi M; Rare Partners S.r.L. Impresa Sociale, 20123 Milano, Italy.
Finotti A; Department of Life Sciences and Biotechnology, Ferrara University, 44121 Ferrara, Italy.; Center 'Chiara Gemmo and Elio Zago' for the Research on Thalassemia, Ferrara University, 44121 Ferrara, Italy.
Gambari R; Department of Life Sciences and Biotechnology, Ferrara University, 44121 Ferrara, Italy.; Center 'Chiara Gemmo and Elio Zago' for the Research on Thalassemia, Ferrara University, 44121 Ferrara, Italy.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Oct 10; Vol. 24 (20). Date of Electronic Publication: 2023 Oct 10.
Typ publikacji:: Journal Article
MeSH Terms:: beta-Thalassemia*/drug therapy
beta-Thalassemia*/genetics
beta-Thalassemia*/metabolism
Adult ; Humans ; Sirolimus/pharmacology ; Sirolimus/therapeutic use ; Fetal Hemoglobin ; alpha-Globins/genetics ; alpha-Globins/metabolism ; RNA, Messenger/genetics ; Autophagy ; Autophagy-Related Protein-1 Homolog/genetics ; Intracellular Signaling Peptides and Proteins/genetics

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Skocz do pozycji: 7.

Tytuł:: Hypoxic mesenchymal stem cell-derived exosomes promote the survival of skin flaps after ischaemia-reperfusion injury via mTOR/ULK1/FUNDC1 pathways.
Autorzy:: Deng C; Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China.
Dong K; Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China.
Liu Y; Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China.
Chen K; Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China.
Min C; Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China.
Cao Z; Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China.
Wu P; Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China.
Luo G; Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China.
Cheng G; Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China.
Qing L; Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China. .
Tang J; Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China. .; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital of Central South University, Changsha, China. .; Pokaż więcej
Źródło:: Journal of nanobiotechnology [J Nanobiotechnology] 2023 Sep 21; Vol. 21 (1), pp. 340. Date of Electronic Publication: 2023 Sep 21.
Typ publikacji:: Journal Article
MeSH Terms:: Exosomes*
Reperfusion Injury*/therapy
MicroRNAs*/genetics
Humans ; Endothelial Cells ; Oxidative Stress ; Hypoxia ; Autophagy-Related Protein-1 Homolog ; Intracellular Signaling Peptides and Proteins/genetics ; Membrane Proteins ; Mitochondrial Proteins

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Skocz do pozycji: 8.

Tytuł:: Lifelong Ulk1-Mediated Autophagy Deficiency in Muscle Induces Mitochondrial Dysfunction and Contractile Weakness.
Autorzy:: Nichenko AS; Department of Kinesiology, University of Georgia, Athens, GA 30602, USA.; Regenerative Bioscience Center, University of Georgia, Athens, GA 30602, USA.
Sorensen JR; School of Kinesiology, University of Minnesota, Minneapolis, MN 55455, USA.
Southern WM; Department of Kinesiology, University of Georgia, Athens, GA 30602, USA.; Regenerative Bioscience Center, University of Georgia, Athens, GA 30602, USA.
Qualls AE; Regenerative Bioscience Center, University of Georgia, Athens, GA 30602, USA.
Schifino AG; Department of Kinesiology, University of Georgia, Athens, GA 30602, USA.; Regenerative Bioscience Center, University of Georgia, Athens, GA 30602, USA.
McFaline-Figueroa J; Department of Kinesiology, University of Georgia, Athens, GA 30602, USA.; Regenerative Bioscience Center, University of Georgia, Athens, GA 30602, USA.
Blum JE; Division of Nutrition Science, Cornell University, Ithaca, NY 14850, USA.
Tehrani KF; Regenerative Bioscience Center, University of Georgia, Athens, GA 30602, USA.
Yin H; Center for Molecular Medicine, University of Georgia, Athens, GA 30602, USA.
Mortensen LJ; Regenerative Bioscience Center, University of Georgia, Athens, GA 30602, USA.
Thalacker-Mercer AE; Division of Nutrition Science, Cornell University, Ithaca, NY 14850, USA.; Department of Cell, Developmental and Integrative Biology, University of Alabama, Birmingham, AL 35294, USA.
Greising SM; School of Kinesiology, University of Minnesota, Minneapolis, MN 55455, USA.
Call JA; Department of Kinesiology, University of Georgia, Athens, GA 30602, USA.; Regenerative Bioscience Center, University of Georgia, Athens, GA 30602, USA.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2021 Feb 16; Vol. 22 (4). Date of Electronic Publication: 2021 Feb 16.
Typ publikacji:: Journal Article
MeSH Terms:: Aging/*metabolism
Autophagy/*genetics
Autophagy-Related Protein-1 Homolog/*deficiency
Autophagy-Related Protein-1 Homolog/*metabolism
Intracellular Signaling Peptides and Proteins/*metabolism
Mitochondria/*metabolism
Muscle Contraction/*genetics
Muscle Fibers, Skeletal/*metabolism
Muscle Weakness/*metabolism
Signal Transduction/*genetics
Adult ; Aged ; Aged, 80 and over ; Animals ; Autophagosomes/metabolism ; Autophagy-Related Protein-1 Homolog/genetics ; Female ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Middle Aged ; Neuromuscular Junction/metabolism ; Phosphorylation/genetics ; Reactive Oxygen Species/metabolism ; Young Adult

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Skocz do pozycji: 9.

Tytuł:: AMPK, metabolism, and vascular function.
Autorzy:: Rodríguez C; Departamento de Fisiología, Facultad de Farmacia, Universidad Complutense, Madrid, Spain.
Muñoz M; Departamento de Fisiología, Facultad de Farmacia, Universidad Complutense, Madrid, Spain.
Contreras C; Departamento de Fisiología, Facultad de Farmacia, Universidad Complutense, Madrid, Spain.
Prieto D; Departamento de Fisiología, Facultad de Farmacia, Universidad Complutense, Madrid, Spain.; Pokaż więcej
Źródło:: The FEBS journal [FEBS J] 2021 Jun; Vol. 288 (12), pp. 3746-3771. Date of Electronic Publication: 2021 Apr 19.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:: AMP-Activated Protein Kinases/*metabolism
Autophagy-Related Protein-1 Homolog/*metabolism
Blood Vessels/*metabolism
Cardiovascular Diseases/*metabolism
Hypoxia/*metabolism
Intracellular Signaling Peptides and Proteins/*metabolism
Metabolic Diseases/*metabolism
AMP-Activated Protein Kinases/genetics ; Adenosine Monophosphate/metabolism ; Animals ; Autophagy/genetics ; Autophagy-Related Protein-1 Homolog/genetics ; Blood Vessels/pathology ; Cardiovascular Diseases/genetics ; Cardiovascular Diseases/pathology ; Gene Expression Regulation ; Glucose/metabolism ; Humans ; Hypoxia/genetics ; Hypoxia/pathology ; Intracellular Signaling Peptides and Proteins/genetics ; Lipid Metabolism/genetics ; Metabolic Diseases/genetics ; Metabolic Diseases/pathology ; Mitochondria/metabolism ; Mitochondria/pathology ; Reactive Oxygen Species/metabolism ; Signal Transduction ; Stress, Physiological

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Skocz do pozycji: 10.

Tytuł:: Dexamethasone Downregulates Autophagy through Accelerated Turn-Over of the Ulk-1 Complex in a Trabecular Meshwork Cells Strain: Insights on Steroid-Induced Glaucoma Pathogenesis.
Autorzy:: Sbardella D; IRCCS-Fondazione Bietti, 00198 Rome, Italy.
Tundo GR; IRCCS-Fondazione Bietti, 00198 Rome, Italy.
Coletta M; Department of Clinical Sciences and Translational Medicine, University of Tor Vergata, 00133 Rome, Italy.
Manni G; Department of Clinical Sciences and Translational Medicine, University of Tor Vergata, 00133 Rome, Italy.
Oddone F; IRCCS-Fondazione Bietti, 00198 Rome, Italy.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2021 May 31; Vol. 22 (11). Date of Electronic Publication: 2021 May 31.
Typ publikacji:: Journal Article
MeSH Terms:: Autophagy/*drug effects
Autophagy-Related Protein-1 Homolog/*metabolism
Dexamethasone/*pharmacology
Intracellular Signaling Peptides and Proteins/*metabolism
Multiprotein Complexes/*metabolism
Trabecular Meshwork/*drug effects
Trabecular Meshwork/*metabolism
Apoptosis/drug effects ; Autophagy/genetics ; Autophagy-Related Protein-1 Homolog/genetics ; Cell Proliferation/drug effects ; Dexamethasone/adverse effects ; Disease Susceptibility ; Glaucoma/etiology ; Glaucoma/metabolism ; Glaucoma/physiopathology ; Humans ; Intracellular Signaling Peptides and Proteins/genetics ; Proteasome Endopeptidase Complex/metabolism

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Skocz do pozycji: 11.

Tytuł:: Oscillation of Autophagy Induction under Cellular Stress and What Lies behind It, a Systems Biology Study.
Autorzy:: Hajdú B; Department of Molecular Biology, Institute of Biochemistry and Molecular Biology, Semmelweis University, 1085 Budapest, Hungary.
Csabai L; Earlham Institute, Norwich Research Park, Norwich NR4 7UG, UK.; Department of Genetics, Eötvös Loránd University, 1117 Budapest, Hungary.
Márton M; Department of Molecular Biology, Institute of Biochemistry and Molecular Biology, Semmelweis University, 1085 Budapest, Hungary.
Holczer M; Department of Molecular Biology, Institute of Biochemistry and Molecular Biology, Semmelweis University, 1085 Budapest, Hungary.
Korcsmáros T; Earlham Institute, Norwich Research Park, Norwich NR4 7UG, UK.; Department of Genetics, Eötvös Loránd University, 1117 Budapest, Hungary.; Quadram Institute Bioscience, Norwich Research Park, Norwich NR4 7UQ, UK.; Department of Metabolism, Digestion and Reproduction, Imperial College London, London W12 0NN, UK.
Kapuy O; Department of Molecular Biology, Institute of Biochemistry and Molecular Biology, Semmelweis University, 1085 Budapest, Hungary.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Apr 21; Vol. 24 (8). Date of Electronic Publication: 2023 Apr 21.
Typ publikacji:: Journal Article
MeSH Terms:: AMP-Activated Protein Kinases*/metabolism
Intracellular Signaling Peptides and Proteins*/pharmacology
Autophagy-Related Protein-1 Homolog/genetics ; Autophagy-Related Protein-1 Homolog/metabolism ; Systems Biology ; TOR Serine-Threonine Kinases/metabolism ; Autophagy

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Skocz do pozycji: 12.

Tytuł:: A novel palmitic acid hydroxy stearic acid (5-PAHSA) plays a neuroprotective role by inhibiting phosphorylation of the m-TOR-ULK1 pathway and regulating autophagy.
Autorzy:: Wang JT; Department of Geriatric Neurology of Huashan Hospital, National Clinical Research Center for Aging and Medicine, Fudan University, Shanghai, China.
Yu ZY; Department of Geriatric Neurology of Huashan Hospital, National Clinical Research Center for Aging and Medicine, Fudan University, Shanghai, China.
Tao YH; Department of Medical Examination Center, Huashan Hospital, Fudan University, Shanghai, China.
Liu YC; Department of Neurosurgery, Provincial Hospital Affiliated to Shandong University, Jinan, China.
Wang YM; Department of Geriatric Neurology of Huashan Hospital, National Clinical Research Center for Aging and Medicine, Fudan University, Shanghai, China.
Guo QL; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Department of Translational Neuroscience, Jing'an District Centre Hospital of Shanghai, Fudan University, Shanghai, China.
Xue JZ; Department of Neurology, Fifth Clinical Medical College of Yangzhou University, Changshu Second People's Hospital of Jiangsu Province, Changshu, China.
Wen XH; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Department of Translational Neuroscience, Jing'an District Centre Hospital of Shanghai, Fudan University, Shanghai, China.
Zhang Q; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Department of Translational Neuroscience, Jing'an District Centre Hospital of Shanghai, Fudan University, Shanghai, China.
Xu XD; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Department of Translational Neuroscience, Jing'an District Centre Hospital of Shanghai, Fudan University, Shanghai, China.
He CF; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Department of Translational Neuroscience, Jing'an District Centre Hospital of Shanghai, Fudan University, Shanghai, China.
Xue WJ; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Department of Translational Neuroscience, Jing'an District Centre Hospital of Shanghai, Fudan University, Shanghai, China.
Guo JC; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Department of Translational Neuroscience, Jing'an District Centre Hospital of Shanghai, Fudan University, Shanghai, China.
Zhou HG; Department of Geriatric Neurology of Huashan Hospital, National Clinical Research Center for Aging and Medicine, Fudan University, Shanghai, China.; Pokaż więcej
Źródło:: CNS neuroscience & therapeutics [CNS Neurosci Ther] 2021 Apr; Vol. 27 (4), pp. 484-496. Date of Electronic Publication: 2021 Jan 18.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Autophagy/*drug effects
Autophagy-Related Protein-1 Homolog/*antagonists & inhibitors
Neuroprotective Agents/*pharmacology
Palmitic Acid/*pharmacology
Stearic Acids/*pharmacology
TOR Serine-Threonine Kinases/*antagonists & inhibitors
Animals ; Autophagy/physiology ; Autophagy-Related Protein-1 Homolog/metabolism ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Neuroprotective Agents/therapeutic use ; PC12 Cells ; Palmitic Acid/therapeutic use ; Phosphorylation/drug effects ; Phosphorylation/physiology ; Rats ; Signal Transduction/drug effects ; Signal Transduction/physiology ; Stearic Acids/therapeutic use ; TOR Serine-Threonine Kinases/metabolism

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Skocz do pozycji: 13.

Tytuł:: Activating autophagy and ferroptosis of 3‑Chloropropane‑1,2‑diol induces injury of human umbilical vein endothelial cells via AMPK/mTOR/ULK1.
Autorzy:: Yi X; Department of Cardiovasology, North China University of Science and Technology Affiliated Hospital, Tangshan, Hebei 063000, P.R. China.
Long X; Department of Cardiovasology, North China University of Science and Technology Affiliated Hospital, Tangshan, Hebei 063000, P.R. China.
Liu C; Department of Cardiovasology, North China University of Science and Technology Affiliated Hospital, Tangshan, Hebei 063000, P.R. China.; Pokaż więcej
Źródło:: Molecular medicine reports [Mol Med Rep] 2023 Mar; Vol. 27 (3). Date of Electronic Publication: 2023 Feb 17.
Typ publikacji:: Journal Article
MeSH Terms:: Ferroptosis*
alpha-Chlorohydrin*/pharmacology
alpha-Chlorohydrin*/metabolism
Humans ; Human Umbilical Vein Endothelial Cells/metabolism ; AMP-Activated Protein Kinases/metabolism ; TOR Serine-Threonine Kinases/metabolism ; Autophagy ; Autophagy-Related Protein-1 Homolog/metabolism ; Intracellular Signaling Peptides and Proteins/metabolism

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Skocz do pozycji: 14.

Tytuł:: A pan-cancer assessment of alterations of the kinase domain of ULK1, an upstream regulator of autophagy.
Autorzy:: Kumar M; Computational Biology Laboratory, Center for Autophagy, Recycling and Disease (CARD), Danish Cancer Society Research Center, Strandboulevarden 49, 2100, Copenhagen, Denmark.
Papaleo E; Computational Biology Laboratory, Center for Autophagy, Recycling and Disease (CARD), Danish Cancer Society Research Center, Strandboulevarden 49, 2100, Copenhagen, Denmark. .; Translational Disease System Biology, Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2020 Sep 10; Vol. 10 (1), pp. 14874. Date of Electronic Publication: 2020 Sep 10.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Autophagy-Related Protein-1 Homolog/*metabolism
Intracellular Signaling Peptides and Proteins/*metabolism
Neoplasms/*enzymology
Autophagy/physiology ; Autophagy-Related Protein-1 Homolog/chemistry ; Autophagy-Related Protein-1 Homolog/genetics ; Humans ; Intracellular Signaling Peptides and Proteins/chemistry ; Intracellular Signaling Peptides and Proteins/genetics ; Molecular Dynamics Simulation ; Mutation ; Neoplasms/genetics ; Neoplasms/pathology ; Phosphorylation ; Protein Structural Elements ; Signal Transduction ; Structure-Activity Relationship

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Skocz do pozycji: 15.

Tytuł:: Absence of ULK1 decreases AMPK activity in the kidney, leading to chronic kidney disease progression.
Autorzy:: Yanagi T; Department of Nephrology, Tokyo Medical and Dental University, Tokyo, Japan.
Kikuchi H; Department of Nephrology, Tokyo Medical and Dental University, Tokyo, Japan.; Epithelial Systems Biology Laboratory, Systems Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
Susa K; Department of Nephrology, Tokyo Medical and Dental University, Tokyo, Japan.
Takahashi N; Department of Nephrology, Tokyo Medical and Dental University, Tokyo, Japan.
Bamba H; Department of Nephrology, Tokyo Medical and Dental University, Tokyo, Japan.
Suzuki T; Department of Nephrology, Tokyo Medical and Dental University, Tokyo, Japan.
Nakano Y; Department of Nephrology, Tokyo Medical and Dental University, Tokyo, Japan.
Fujiki T; Department of Nephrology, Tokyo Medical and Dental University, Tokyo, Japan.
Mori Y; Department of Nephrology, Tokyo Medical and Dental University, Tokyo, Japan.
Ando F; Department of Nephrology, Tokyo Medical and Dental University, Tokyo, Japan.
Mandai S; Department of Nephrology, Tokyo Medical and Dental University, Tokyo, Japan.
Mori T; Department of Nephrology, Tokyo Medical and Dental University, Tokyo, Japan.
Takeuchi K; Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.
Honda S; Department of Pathological Cell Biology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.
Torii S; Department of Pathological Cell Biology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.
Shimizu S; Department of Pathological Cell Biology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.
Rai T; Department of Nephrology, Tokyo Medical and Dental University, Tokyo, Japan.
Uchida S; Department of Nephrology, Tokyo Medical and Dental University, Tokyo, Japan.
Sohara E; Department of Nephrology, Tokyo Medical and Dental University, Tokyo, Japan.; Pokaż więcej
Źródło:: Genes to cells : devoted to molecular & cellular mechanisms [Genes Cells] 2023 Jan; Vol. 28 (1), pp. 5-14. Date of Electronic Publication: 2022 Nov 09.
Typ publikacji:: Journal Article
MeSH Terms:: AMP-Activated Protein Kinases*/genetics
AMP-Activated Protein Kinases*/metabolism
Renal Insufficiency, Chronic*/metabolism
Mice ; Animals ; Autophagy-Related Protein-1 Homolog/genetics ; Autophagy-Related Protein-1 Homolog/metabolism ; Kidney/metabolism ; Phosphorylation ; Autophagy

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Skocz do pozycji: 16.

Tytuł:: ULK1 inhibition as a targeted therapeutic strategy for FLT3-ITD-mutated acute myeloid leukemia.
Autorzy:: Hwang DY; Division of Hematology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea.
Eom JI; Avison Biomedical Research Center, Yonsei University College of Medicine, Seoul, 03722, South Korea.
Jang JE; Division of Hematology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea.
Jeung HK; Avison Biomedical Research Center, Yonsei University College of Medicine, Seoul, 03722, South Korea.
Chung H; Division of Hematology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea.
Kim JS; Division of Hematology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea.
Cheong JW; Division of Hematology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea.
Min YH; Division of Hematology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea. .; Pokaż więcej
Źródło:: Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2020 May 11; Vol. 39 (1), pp. 85. Date of Electronic Publication: 2020 May 11.
Typ publikacji:: Journal Article
MeSH Terms:: Mutation*
Autophagy-Related Protein-1 Homolog/*antagonists & inhibitors
Intracellular Signaling Peptides and Proteins/*antagonists & inhibitors
Leukemia, Myeloid, Acute/*drug therapy
fms-Like Tyrosine Kinase 3/*genetics
Apoptosis/drug effects ; Autophagy/drug effects ; Autophagy-Related Protein-1 Homolog/biosynthesis ; Autophagy-Related Protein-1 Homolog/metabolism ; Benzamides/pharmacology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Humans ; Intracellular Signaling Peptides and Proteins/biosynthesis ; Intracellular Signaling Peptides and Proteins/metabolism ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/metabolism ; Leukemia, Myeloid, Acute/pathology ; Molecular Targeted Therapy ; Protein Kinase Inhibitors/pharmacology ; Pyrimidines/pharmacology ; Transfection ; fms-Like Tyrosine Kinase 3/metabolism

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Skocz do pozycji: 17.

Tytuł:: Long non‑coding RNA growth arrest‑specific 5 (GAS5) acts as a tumor suppressor by promoting autophagy in breast cancer.
Autorzy:: Li G; Integration of Traditional and Western Medicine and Oncology, Chengdu, Sichuan 610072, P.R. China.
Qian L; The Teaching Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610072, P.R. China.
Tang X; Department of Pathology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China.
Chen Y; Department of Pathology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China.
Zhao Z; The Teaching Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610072, P.R. China.
Zhang C; Department of Pathology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China.; Pokaż więcej
Źródło:: Molecular medicine reports [Mol Med Rep] 2020 Sep; Vol. 22 (3), pp. 2460-2468. Date of Electronic Publication: 2020 Jul 10.
Typ publikacji:: Journal Article
MeSH Terms:: Autophagy-Related Protein-1 Homolog/*genetics
Breast Neoplasms/*genetics
Intracellular Signaling Peptides and Proteins/*genetics
Protein Serine-Threonine Kinases/*genetics
RNA, Long Noncoding/*genetics
Adult ; Aged ; Aged, 80 and over ; Autophagy ; Autophagy-Related Protein-1 Homolog/metabolism ; Breast Neoplasms/metabolism ; Cell Line, Tumor ; Down-Regulation ; Female ; Humans ; Intracellular Signaling Peptides and Proteins/metabolism ; MCF-7 Cells ; Middle Aged ; Protein Serine-Threonine Kinases/metabolism

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Skocz do pozycji: 18.

Tytuł:: ULK1 and ULK2 are less redundant than previously thought: computational analysis uncovers distinct regulation and functions of these autophagy induction proteins.
Autorzy:: Demeter A; Earlham Institute, Norwich Research Park, Norwich, NR4 7UZ, UK.; Quadram Institute Bioscience, Norwich Research Park, Norwich, NR4 7UQ, UK.
Romero-Mulero MC; Earlham Institute, Norwich Research Park, Norwich, NR4 7UZ, UK.; Faculty of Biology, University of Seville, 41012, Seville, Spain.
Csabai L; Earlham Institute, Norwich Research Park, Norwich, NR4 7UZ, UK.; Eötvös Loránd University, Budapest, 1117, Hungary.
Ölbei M; Earlham Institute, Norwich Research Park, Norwich, NR4 7UZ, UK.; Quadram Institute Bioscience, Norwich Research Park, Norwich, NR4 7UQ, UK.
Sudhakar P; Earlham Institute, Norwich Research Park, Norwich, NR4 7UZ, UK.; Quadram Institute Bioscience, Norwich Research Park, Norwich, NR4 7UQ, UK.
Haerty W; Earlham Institute, Norwich Research Park, Norwich, NR4 7UZ, UK.
Korcsmáros T; Earlham Institute, Norwich Research Park, Norwich, NR4 7UZ, UK. .; Quadram Institute Bioscience, Norwich Research Park, Norwich, NR4 7UQ, UK. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2020 Jul 02; Vol. 10 (1), pp. 10940. Date of Electronic Publication: 2020 Jul 02.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Autophagy*
Autophagy-Related Protein-1 Homolog/*metabolism
Autophagy-Related Proteins/*metabolism
Computational Biology/*methods
Intracellular Signaling Peptides and Proteins/*metabolism
Protein Serine-Threonine Kinases/*metabolism
Autophagy-Related Protein-1 Homolog/chemistry ; Autophagy-Related Proteins/chemistry ; Humans ; Intracellular Signaling Peptides and Proteins/chemistry ; Lysosomes ; Protein Binding ; Protein Conformation ; Protein Interaction Mapping ; Protein Serine-Threonine Kinases/chemistry

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Skocz do pozycji: 19.

Tytuł:: Small Molecule Inhibitors for Unc-51-like Autophagy-Activating Kinase Targeting Autophagy in Cancer.
Autorzy:: Karmacharya U; College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu 41566, Republic of Korea.; Vessel-Organ Interaction Research Center, Kyungpook National University, Daegu 41566, Republic of Korea.
Jung JW; College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu 41566, Republic of Korea.; Vessel-Organ Interaction Research Center, Kyungpook National University, Daegu 41566, Republic of Korea.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Jan 04; Vol. 24 (2). Date of Electronic Publication: 2023 Jan 04.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Protein Serine-Threonine Kinases*/metabolism
Neoplasms*/drug therapy
Humans ; Autophagy-Related Protein-1 Homolog/metabolism ; Autophagy

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Skocz do pozycji: 20.

Tytuł:: Osthole Suppresses Knee Osteoarthritis Development by Enhancing Autophagy Activated via the AMPK/ULK1 Pathway.
Autorzy:: Ma T; First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.
Wang X; Department of Orthopedics, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250011, China.
Qu W; First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.
Yang L; Department of Orthopedics, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250011, China.
Jing C; Department of Orthopedics, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250011, China.
Zhu B; Department of Orthopedics, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250011, China.
Zhang Y; Department of Orthopedics, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250011, China.
Xie W; Department of Orthopedics, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250011, China.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2022 Dec 06; Vol. 27 (23). Date of Electronic Publication: 2022 Dec 06.
Typ publikacji:: Journal Article
MeSH Terms:: Autophagy*
Osteoarthritis, Knee*/metabolism
Rats ; Animals ; Chondrocytes ; Signal Transduction ; Apoptosis ; AMP-Activated Protein Kinases/metabolism ; Autophagy-Related Protein-1 Homolog/metabolism

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