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Tytuł :
Donor human leukocyte antigen-G single nucleotide polymorphisms are associated with post-lung transplant mortality.
Autorzy :
Lazarte J; Toronto Lung Transplant Program, Toronto General Hospital, Toronto, ON, Canada.; Cardiac Transplant Program, Toronto General Hospital, Toronto, ON, Canada.
Ma J; University Health Network, University of Toronto, Toronto, Canada.
Martinu T; Toronto Lung Transplant Program, Toronto General Hospital, Toronto, ON, Canada.
Levy L; Toronto Lung Transplant Program, Toronto General Hospital, Toronto, ON, Canada.
Klement W; Toronto Lung Transplant Program, Toronto General Hospital, Toronto, ON, Canada.
White M; Toronto Lung Transplant Program, Toronto General Hospital, Toronto, ON, Canada.
Pelling J; Toronto Lung Transplant Program, Toronto General Hospital, Toronto, ON, Canada.
Guan Z; Toronto Lung Transplant Program, Toronto General Hospital, Toronto, ON, Canada.
Azad S; Toronto Lung Transplant Program, Toronto General Hospital, Toronto, ON, Canada.
Tikkanen J; Toronto Lung Transplant Program, Toronto General Hospital, Toronto, ON, Canada.
Rao V; Cardiac Transplant Program, Toronto General Hospital, Toronto, ON, Canada.
Tomlinson G; University Health Network, University of Toronto, Toronto, Canada.
Delgado D; Cardiac Transplant Program, Toronto General Hospital, Toronto, ON, Canada.
Keshavjee S; Toronto Lung Transplant Program, Toronto General Hospital, Toronto, ON, Canada.
Juvet SC; Toronto Lung Transplant Program, Toronto General Hospital, Toronto, ON, Canada .
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Źródło :
The European respiratory journal [Eur Respir J] 2019 Aug 15; Vol. 54 (2). Date of Electronic Publication: 2019 Aug 15 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Polymorphism, Single Nucleotide*
Tissue Donors*
HLA-G Antigens/*genetics
Lung Transplantation/*mortality
Adult ; Aged ; Alleles ; Biopsy ; DNA/genetics ; Female ; Genotype ; Graft Survival ; Humans ; Kaplan-Meier Estimate ; Leukocytes/cytology ; Lung/pathology ; Male ; Middle Aged ; Multivariate Analysis ; Proportional Hazards Models ; Retrospective Studies ; Risk
Czasopismo naukowe
Tytuł :
Sequential broncho-alveolar lavages reflect distinct pulmonary compartments: clinical and research implications in lung transplantation.
Autorzy :
Levy L; Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, ON, Canada.
Juvet SC; Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, ON, Canada.
Boonstra K; Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, ON, Canada.
Singer LG; Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, ON, Canada.
Azad S; Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, ON, Canada.
Joe B; Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, ON, Canada.
Cypel M; Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, ON, Canada.
Keshavjee S; Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, ON, Canada.
Martinu T; Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, ON, Canada. .; Toronto General Hospital, 585 University Ave, PMB 11-128, Toronto, ON, M5G 2N2, Canada. .
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Źródło :
Respiratory research [Respir Res] 2018 May 25; Vol. 19 (1), pp. 102. Date of Electronic Publication: 2018 May 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Biomedical Research/*trends
Bronchoalveolar Lavage/*trends
Bronchoalveolar Lavage Fluid/*cytology
Lung/*pathology
Lung Transplantation/*trends
Adult ; Aged ; Bronchoscopy/trends ; Cohort Studies ; Female ; Humans ; Lung/surgery ; Male ; Middle Aged ; Retrospective Studies ; Time Factors
Czasopismo naukowe
Tytuł :
Quantitative chest CT for subtyping chronic lung allograft dysfunction and its association with survival.
Autorzy :
Horie M; Joint Department of Medical Imaging, University Health Network, University of Toronto, Toronto, ON, Canada.; Institute for Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, Canada.
Salazar P; Vital Images, Minnetonka, MN, USA.
Saito T; Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, University of Toronto, Toronto, ON, Canada.; Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, ON, Canada.; Department of Thoracic Surgery, Kansai Medical University, Hirakata, Japan.
Binnie M; Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, ON, Canada.
Brock K; Department of Imaging Physics, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
Yasufuku K; Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, University of Toronto, Toronto, ON, Canada.; Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, ON, Canada.
Azad S; Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, University of Toronto, Toronto, ON, Canada.
Keshavjee S; Institute for Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, Canada.; Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, ON, Canada.; Department of Thoracic Surgery, Kansai Medical University, Hirakata, Japan.
Martinu T; Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, ON, Canada.
Paul N; Joint Department of Medical Imaging, University Health Network, University of Toronto, Toronto, ON, Canada.; Institute for Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, Canada.
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Źródło :
Clinical transplantation [Clin Transplant] 2018 May; Vol. 32 (5), pp. e13233. Date of Electronic Publication: 2018 Apr 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Postoperative Complications*
Bronchiolitis Obliterans/*mortality
Graft Rejection/*mortality
Lung Diseases/*mortality
Lung Transplantation/*mortality
Primary Graft Dysfunction/*mortality
Tomography, X-Ray Computed/*methods
Adult ; Allografts ; Bronchiolitis Obliterans/classification ; Bronchiolitis Obliterans/diagnostic imaging ; Bronchiolitis Obliterans/etiology ; Chronic Disease ; Female ; Follow-Up Studies ; Graft Rejection/diagnostic imaging ; Graft Rejection/etiology ; Graft Survival ; Humans ; Lung Diseases/surgery ; Lung Transplantation/adverse effects ; Male ; Middle Aged ; Primary Graft Dysfunction/classification ; Primary Graft Dysfunction/diagnostic imaging ; Primary Graft Dysfunction/etiology ; Prognosis ; Radiography, Thoracic ; Respiratory Function Tests ; Retrospective Studies ; Risk Factors
Czasopismo naukowe
Tytuł :
Extracorporeal life support as a bridge to lung transplantation-experience of a high-volume transplant center.
Autorzy :
Hoetzenecker K; Toronto Lung Transplant Program, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada; Department of Thoracic Surgery, Medical University of Vienna, Vienna, Austria.
Donahoe L; Toronto Lung Transplant Program, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Yeung JC; Toronto Lung Transplant Program, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Azad S; Toronto Lung Transplant Program, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Fan E; Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada.
Ferguson ND; Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada.
Del Sorbo L; Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada.
de Perrot M; Toronto Lung Transplant Program, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Pierre A; Toronto Lung Transplant Program, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Yasufuku K; Toronto Lung Transplant Program, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Singer L; Toronto Lung Transplant Program, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Waddell TK; Toronto Lung Transplant Program, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Keshavjee S; Toronto Lung Transplant Program, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Cypel M; Toronto Lung Transplant Program, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada. Electronic address: .
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Źródło :
The Journal of thoracic and cardiovascular surgery [J Thorac Cardiovasc Surg] 2018 Mar; Vol. 155 (3), pp. 1316-1328.e1. Date of Electronic Publication: 2017 Nov 22.
Typ publikacji :
Journal Article; Webcast
MeSH Terms :
Extracorporeal Membrane Oxygenation*/adverse effects
Extracorporeal Membrane Oxygenation*/mortality
Hospitals, High-Volume*
Lung Transplantation*
Lung Diseases/*surgery
Adolescent ; Adult ; Aged ; Clinical Decision-Making ; Databases, Factual ; Female ; Humans ; Lung Diseases/diagnosis ; Lung Diseases/mortality ; Lung Diseases/physiopathology ; Male ; Middle Aged ; Ontario ; Patient Selection ; Recovery of Function ; Retrospective Studies ; Risk Factors ; Time Factors ; Treatment Outcome ; Waiting Lists ; Young Adult
Czasopismo naukowe
Tytuł :
Soluble Adhesion Molecules During Ex Vivo Lung Perfusion Are Associated With Posttransplant Primary Graft Dysfunction.
Autorzy :
Hashimoto K; Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, University of Toronto, Toronto, Canada.
Cypel M; Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, University of Toronto, Toronto, Canada.
Kim H; Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, University of Toronto, Toronto, Canada.
Machuca TN; Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, University of Toronto, Toronto, Canada.
Nakajima D; Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, University of Toronto, Toronto, Canada.
Chen M; Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, University of Toronto, Toronto, Canada.
Hsin MK; Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, University of Toronto, Toronto, Canada.
Zamel R; Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, University of Toronto, Toronto, Canada.
Azad S; Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, University of Toronto, Toronto, Canada.
Waddell TK; Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, University of Toronto, Toronto, Canada.
Liu M; Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, University of Toronto, Toronto, Canada.
Keshavjee S; Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, University of Toronto, Toronto, Canada.
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Źródło :
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons [Am J Transplant] 2017 May; Vol. 17 (5), pp. 1396-1404. Date of Electronic Publication: 2017 Feb 01.
Typ publikacji :
Journal Article
MeSH Terms :
Tissue Donors*
Biomarkers/*metabolism
Lung Transplantation/*adverse effects
Postoperative Complications/*diagnosis
Primary Graft Dysfunction/*diagnosis
Adult ; E-Selectin/metabolism ; Extracorporeal Circulation ; Female ; Follow-Up Studies ; Humans ; Intercellular Adhesion Molecule-1/metabolism ; Male ; Middle Aged ; Perfusion ; Postoperative Complications/etiology ; Postoperative Complications/metabolism ; Primary Graft Dysfunction/etiology ; Primary Graft Dysfunction/metabolism ; Prognosis ; Retrospective Studies ; Vascular Cell Adhesion Molecule-1/metabolism
Czasopismo naukowe
Tytuł :
Lung Lavage and Surfactant Replacement During Ex Vivo Lung Perfusion for Treatment of Gastric Acid Aspiration-Induced Donor Lung Injury.
Autorzy :
Nakajima D; Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, and University of Toronto, Toronto, Ontario, Canada.
Liu M; Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, and University of Toronto, Toronto, Ontario, Canada.
Ohsumi A; Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, and University of Toronto, Toronto, Ontario, Canada.
Kalaf R; Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, and University of Toronto, Toronto, Ontario, Canada.
Iskender I; Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, and University of Toronto, Toronto, Ontario, Canada.
Hsin M; Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, and University of Toronto, Toronto, Ontario, Canada.
Kanou T; Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, and University of Toronto, Toronto, Ontario, Canada.
Chen M; Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, and University of Toronto, Toronto, Ontario, Canada.
Baer B; the Department of Physiology and Pharmacology, Lawson Health Research Institute, University of Western Ontario, London, Ontario, Canada.
Coutinho R; Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, and University of Toronto, Toronto, Ontario, Canada.
Maahs L; Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, and University of Toronto, Toronto, Ontario, Canada.
Behrens P; Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, and University of Toronto, Toronto, Ontario, Canada.
Azad S; Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, and University of Toronto, Toronto, Ontario, Canada.
Martinu T; Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, and University of Toronto, Toronto, Ontario, Canada.
Waddell TK; Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, and University of Toronto, Toronto, Ontario, Canada.
Lewis JF; the Department of Physiology and Pharmacology, Lawson Health Research Institute, University of Western Ontario, London, Ontario, Canada.
Post M; the Physiology and Experimental Medicine Program, The Hospital for Sick Children, Toronto, Ontario, Canada.
Veldhuizen RAW; the Department of Physiology and Pharmacology, Lawson Health Research Institute, University of Western Ontario, London, Ontario, Canada.
Cypel M; Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, and University of Toronto, Toronto, Ontario, Canada.
Keshavjee S; Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, and University of Toronto, Toronto, Ontario, Canada. Electronic address: .
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Źródło :
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation [J Heart Lung Transplant] 2017 May; Vol. 36 (5), pp. 577-585. Date of Electronic Publication: 2016 Dec 01.
Typ publikacji :
Journal Article
MeSH Terms :
Bronchoalveolar Lavage/*methods
Lung Injury/*surgery
Lung Transplantation/*methods
Organ Preservation/*methods
Pulmonary Surfactants/*pharmacology
Reperfusion Injury/*prevention & control
Analysis of Variance ; Animals ; Disease Models, Animal ; Extracorporeal Circulation/methods ; Gastric Acid ; Lung Injury/physiopathology ; Lung Transplantation/adverse effects ; Male ; Preoperative Care/methods ; Random Allocation ; Respiratory Function Tests ; Statistics, Nonparametric ; Sus scrofa ; Swine ; Tissue Donors
Czasopismo naukowe
Tytuł :
De Novo DQ Donor-Specific Antibodies Are Associated with Chronic Lung Allograft Dysfunction after Lung Transplantation.
Autorzy :
Tikkanen JM; 1 Toronto Lung Transplant Program.
Singer LG; 1 Toronto Lung Transplant Program.
Kim SJ; 2 Division of Nephrology, Department of Medicine, and.
Li Y; 2 Division of Nephrology, Department of Medicine, and.
Binnie M; 1 Toronto Lung Transplant Program.
Chaparro C; 1 Toronto Lung Transplant Program.
Chow CW; 1 Toronto Lung Transplant Program.
Martinu T; 1 Toronto Lung Transplant Program.
Azad S; 1 Toronto Lung Transplant Program.
Keshavjee S; 1 Toronto Lung Transplant Program.
Tinckam K; 2 Division of Nephrology, Department of Medicine, and.; 3 HLA Laboratory, Laboratory Medicine Program, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada.
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Źródło :
American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2016 Sep 01; Vol. 194 (5), pp. 596-606.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Tissue Donors*
Allografts/*immunology
Bronchiolitis Obliterans/*immunology
Graft Rejection/*immunology
HLA Antigens/*immunology
Lung/*immunology
Lung Transplantation/*adverse effects
Allografts/statistics & numerical data ; Bronchiolitis Obliterans/epidemiology ; Bronchiolitis Obliterans/etiology ; Female ; Graft Rejection/complications ; Graft Rejection/epidemiology ; Humans ; Immunosuppressive Agents/administration & dosage ; Kaplan-Meier Estimate ; Lung Transplantation/statistics & numerical data ; Male ; Middle Aged ; Ontario/epidemiology ; Proportional Hazards Models ; Retrospective Studies ; Sex Distribution
Czasopismo naukowe
Tytuł :
Circulating Cell Death Biomarkers May Predict Survival in Human Lung Transplantation.
Autorzy :
Hashimoto K; 1 Latner Thoracic Surgery Research Laboratories, Division of Thoracic Surgery, University of Toronto, Toronto, Canada; and.; 2 Division of Thoracic Surgery, Keio University School of Medicine, Tokyo, Japan.
Besla R; 1 Latner Thoracic Surgery Research Laboratories, Division of Thoracic Surgery, University of Toronto, Toronto, Canada; and.
Zamel R; 1 Latner Thoracic Surgery Research Laboratories, Division of Thoracic Surgery, University of Toronto, Toronto, Canada; and.
Juvet S; 1 Latner Thoracic Surgery Research Laboratories, Division of Thoracic Surgery, University of Toronto, Toronto, Canada; and.
Kim H; 1 Latner Thoracic Surgery Research Laboratories, Division of Thoracic Surgery, University of Toronto, Toronto, Canada; and.
Azad S; 1 Latner Thoracic Surgery Research Laboratories, Division of Thoracic Surgery, University of Toronto, Toronto, Canada; and.
Waddell TK; 1 Latner Thoracic Surgery Research Laboratories, Division of Thoracic Surgery, University of Toronto, Toronto, Canada; and.
Cypel M; 1 Latner Thoracic Surgery Research Laboratories, Division of Thoracic Surgery, University of Toronto, Toronto, Canada; and.
Liu M; 1 Latner Thoracic Surgery Research Laboratories, Division of Thoracic Surgery, University of Toronto, Toronto, Canada; and.
Keshavjee S; 1 Latner Thoracic Surgery Research Laboratories, Division of Thoracic Surgery, University of Toronto, Toronto, Canada; and.
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Źródło :
American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2016 Jul 01; Vol. 194 (1), pp. 97-105.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Death*
Lung Transplantation*
Postoperative Complications/*blood
Primary Graft Dysfunction/*blood
Adult ; Biomarkers/blood ; Enzyme-Linked Immunosorbent Assay ; Extracorporeal Membrane Oxygenation/statistics & numerical data ; Female ; Humans ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Predictive Value of Tests ; Proportional Hazards Models ; Reproducibility of Results ; Retrospective Studies ; Survival Analysis
Czasopismo naukowe
Tytuł :
Ex Vivo Perfusion Treatment of Infection in Human Donor Lungs.
Autorzy :
Nakajima D; Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Cypel M; Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Bonato R; Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Machuca TN; Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Iskender I; Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Hashimoto K; Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Linacre V; Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Chen M; Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Coutinho R; Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Azad S; Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Martinu T; Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Waddell TK; Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Hwang DM; Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Husain S; Transplant Infectious Diseases, Multi-Organ Transplant Program, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Liu M; Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Keshavjee S; Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada.
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Źródło :
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons [Am J Transplant] 2016 Apr; Vol. 16 (4), pp. 1229-37. Date of Electronic Publication: 2016 Jan 05.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anti-Infective Agents/*administration & dosage
Lung/*microbiology
Lung Transplantation/*standards
Perfusion/*methods
Tissue and Organ Procurement/*standards
Adult ; Anti-Infective Agents/pharmacology ; Bacterial Load ; Bronchoalveolar Lavage Fluid/microbiology ; Bronchopneumonia/drug therapy ; Bronchopneumonia/microbiology ; Bronchopneumonia/pathology ; Case-Control Studies ; Extracorporeal Circulation ; Female ; Follow-Up Studies ; Humans ; Lung/drug effects ; Male ; Middle Aged ; Prognosis ; Tissue Donors
Czasopismo naukowe
Tytuł :
Low-dose computed tomography volumetry for subtyping chronic lung allograft dysfunction.
Autorzy :
Saito T; Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute and Division of Thoracic Surgery, University Health Network, University of Toronto, Toronto, Ontario, Canada; Department of Thoracic and Cardiovascular Surgery, Kansai Medical University, Hirakara, Japan.
Horie M; Cardiothoracic Division, Department of Medical Imaging, Time Resolved Imaging and Image Optimization Core Laboratory, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Sato M; Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute and Division of Thoracic Surgery, University Health Network, University of Toronto, Toronto, Ontario, Canada; Department of Thoracic Surgery, Kyoto University, Kyoto, Japan.
Nakajima D; Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute and Division of Thoracic Surgery, University Health Network, University of Toronto, Toronto, Ontario, Canada; Department of Thoracic Surgery, Kyoto University, Kyoto, Japan.
Shoushtarizadeh H; Cardiothoracic Division, Department of Medical Imaging, Time Resolved Imaging and Image Optimization Core Laboratory, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Binnie M; Division of Respirology, Department of Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Azad S; Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute and Division of Thoracic Surgery, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Hwang DM; Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute and Division of Thoracic Surgery, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Machuca TN; Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute and Division of Thoracic Surgery, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Waddell TK; Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute and Division of Thoracic Surgery, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Singer LG; Division of Respirology, Department of Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Cypel M; Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute and Division of Thoracic Surgery, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Liu M; Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute and Division of Thoracic Surgery, University Health Network, University of Toronto, Toronto, Ontario, Canada; Division of Respirology, Department of Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Paul NS; Cardiothoracic Division, Department of Medical Imaging, Time Resolved Imaging and Image Optimization Core Laboratory, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Keshavjee S; Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute and Division of Thoracic Surgery, University Health Network, University of Toronto, Toronto, Ontario, Canada; Department of Thoracic and Cardiovascular Surgery, Kansai Medical University, Hirakara, Japan. Electronic address: .
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Źródło :
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation [J Heart Lung Transplant] 2016 Jan; Vol. 35 (1), pp. 59-66. Date of Electronic Publication: 2015 Aug 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bronchiolitis Obliterans/*surgery
Lung/*diagnostic imaging
Lung Transplantation/*adverse effects
Primary Graft Dysfunction/*diagnostic imaging
Total Lung Capacity/*physiology
Adult ; Allografts ; Female ; Follow-Up Studies ; Graft Rejection ; Humans ; Lung/physiopathology ; Lung/surgery ; Male ; Middle Aged ; Organ Size ; Primary Graft Dysfunction/physiopathology ; ROC Curve ; Radiation Dosage ; Retrospective Studies ; Risk Factors ; Time Factors ; Tomography, X-Ray Computed
Czasopismo naukowe
Tytuł :
The Effectiveness of Culture-Directed Preemptive Anti-Aspergillus Treatment in Lung Transplant Recipients at One Year After Transplant.
Autorzy :
Hosseini-Moghaddam SM; 1 Division of Infectious Diseases, Transplant Infectious Diseases, Western University, London, ON, Canada. 2 Division of Infectious Diseases, Transplant Infectious Diseases, Toronto General Hospital, University Health Network, University of Toronto, Toronto, ON, Canada. 3 Toronto Lung Transplantation Program, Toronto General Hospital, University Health Network, University of Toronto, Toronto, ON, Canada. 4 Department of Medical Microbiology and Infectious Diseases, Hôpital Saint-Luc, Montreal, QC, Canada. 5 Department of Laboratory Medicine, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada.
Chaparro C
Luong ML
Azad S
Singer LG
Mazzulli T
Rotstein C
Keshavjee S
Husain S
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Źródło :
Transplantation [Transplantation] 2015 Nov; Vol. 99 (11), pp. 2387-93.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antifungal Agents/*administration & dosage
Aspergillus/*drug effects
Invasive Pulmonary Aspergillosis/*prevention & control
Lung Transplantation/*adverse effects
Respiratory System/*microbiology
Adult ; Antilymphocyte Serum/adverse effects ; Aspergillus/classification ; Aspergillus/immunology ; Aspergillus/isolation & purification ; Chi-Square Distribution ; Drug Administration Schedule ; Female ; Humans ; Immunocompromised Host ; Immunosuppressive Agents/adverse effects ; Invasive Pulmonary Aspergillosis/diagnosis ; Invasive Pulmonary Aspergillosis/immunology ; Invasive Pulmonary Aspergillosis/microbiology ; Invasive Pulmonary Aspergillosis/mortality ; Logistic Models ; Lung Transplantation/mortality ; Male ; Middle Aged ; Multivariate Analysis ; Odds Ratio ; Proportional Hazards Models ; Retrospective Studies ; Risk Factors ; Time Factors ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Outcomes of intraoperative extracorporeal membrane oxygenation versus cardiopulmonary bypass for lung transplantation.
Autorzy :
Machuca TN; Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Collaud S; Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Mercier O; Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Cheung M; Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Cunningham V; Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Kim SJ; Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Azad S; Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Singer L; Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Yasufuku K; Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, Ontario, Canada.
de Perrot M; Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Pierre A; Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, Ontario, Canada.
McRae K; Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Waddell TK; Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Keshavjee S; Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Cypel M; Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, Ontario, Canada. Electronic address: .
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Źródło :
The Journal of thoracic and cardiovascular surgery [J Thorac Cardiovasc Surg] 2015 Apr; Vol. 149 (4), pp. 1152-7. Date of Electronic Publication: 2014 Nov 21.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cardiopulmonary Bypass*/adverse effects
Cardiopulmonary Bypass*/mortality
Extracorporeal Membrane Oxygenation*/adverse effects
Extracorporeal Membrane Oxygenation*/mortality
Idiopathic Pulmonary Fibrosis/*surgery
Lung Transplantation/*methods
Pulmonary Disease, Chronic Obstructive/*surgery
Adult ; Aged ; Databases, Factual ; Female ; Humans ; Idiopathic Pulmonary Fibrosis/diagnosis ; Idiopathic Pulmonary Fibrosis/mortality ; Intensive Care Units ; Kaplan-Meier Estimate ; Length of Stay ; Lung Transplantation/adverse effects ; Lung Transplantation/mortality ; Male ; Middle Aged ; Ontario ; Postoperative Complications/mortality ; Postoperative Complications/therapy ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Pulmonary Disease, Chronic Obstructive/mortality ; Respiration, Artificial ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Time Factors ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Lung transplantation with donation after circulatory determination of death donors and the impact of ex vivo lung perfusion.
Autorzy :
Machuca TN; Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, ON, Canada.
Mercier O
Collaud S
Tikkanen J
Krueger T
Yeung JC
Chen M
Azad S
Singer L
Yasufuku K
de Perrot M
Pierre A
Waddell TK
Keshavjee S
Cypel M
Pokaż więcej
Źródło :
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons [Am J Transplant] 2015 Apr; Vol. 15 (4), pp. 993-1002. Date of Electronic Publication: 2015 Mar 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Blood Circulation*
Lung Transplantation*
Tissue Donors*
Adult ; Female ; Humans ; Lung ; Male ; Middle Aged ; Perfusion ; Prognosis ; Retrospective Studies
Czasopismo naukowe
Tytuł :
Functional outcomes and quality of life after normothermic ex vivo lung perfusion lung transplantation.
Autorzy :
Tikkanen JM; Toronto Lung Transplant Program, University Health Network, University of Toronto, Ontario, Canada.
Cypel M; Toronto Lung Transplant Program, University Health Network, University of Toronto, Ontario, Canada.
Machuca TN; Toronto Lung Transplant Program, University Health Network, University of Toronto, Ontario, Canada.
Azad S; Toronto Lung Transplant Program, University Health Network, University of Toronto, Ontario, Canada.
Binnie M; Toronto Lung Transplant Program, University Health Network, University of Toronto, Ontario, Canada.
Chow CW; Toronto Lung Transplant Program, University Health Network, University of Toronto, Ontario, Canada.
Chaparro C; Toronto Lung Transplant Program, University Health Network, University of Toronto, Ontario, Canada.
Hutcheon M; Toronto Lung Transplant Program, University Health Network, University of Toronto, Ontario, Canada.
Yasufuku K; Toronto Lung Transplant Program, University Health Network, University of Toronto, Ontario, Canada.
de Perrot M; Toronto Lung Transplant Program, University Health Network, University of Toronto, Ontario, Canada.
Pierre AF; Toronto Lung Transplant Program, University Health Network, University of Toronto, Ontario, Canada.
Waddell TK; Toronto Lung Transplant Program, University Health Network, University of Toronto, Ontario, Canada.
Keshavjee S; Toronto Lung Transplant Program, University Health Network, University of Toronto, Ontario, Canada.
Singer LG; Toronto Lung Transplant Program, University Health Network, University of Toronto, Ontario, Canada. Electronic address: .
Pokaż więcej
Źródło :
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation [J Heart Lung Transplant] 2015 Apr; Vol. 34 (4), pp. 547-56. Date of Electronic Publication: 2014 Oct 24.
Typ publikacji :
Clinical Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Quality of Life*
Lung Transplantation/*methods
Adolescent ; Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Perfusion/methods ; Preoperative Care ; Recovery of Function ; Retrospective Studies ; Treatment Outcome ; Young Adult
Czasopismo naukowe
Tytuł :
Protein expression profiling predicts graft performance in clinical ex vivo lung perfusion.
Autorzy :
Machuca TN; Toronto Lung Transplant Program, University Health Network; and †Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University of Toronto, Toronto, Ontario, Canada.
Cypel M
Yeung JC
Bonato R
Zamel R
Chen M
Azad S
Hsin MK
Saito T
Guan Z
Waddell TK
Liu M
Keshavjee S
Pokaż więcej
Źródło :
Annals of surgery [Ann Surg] 2015 Mar; Vol. 261 (3), pp. 591-7.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Lung Transplantation*
Tissue Donors*
Cytokines/*metabolism
Lung/*blood supply
Perfusion/*methods
Biomarkers/metabolism ; Brain Death ; Chemokines/metabolism ; Heart Diseases/mortality ; Humans ; In Vitro Techniques ; Intercellular Signaling Peptides and Proteins/metabolism ; Ontario ; Predictive Value of Tests ; Tissue and Organ Procurement/methods
Czasopismo naukowe
Tytuł :
Distinct expression patterns of alveolar "alarmins" in subtypes of chronic lung allograft dysfunction.
Autorzy :
Saito T; Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, University of Toronto, Toronto, ON, Canada; Department of Thoracic and Cardiovascular Surgery, Kansai Medical University, Hirakara, Japan.
Liu M
Binnie M
Sato M
Hwang D
Azad S
Machuca TN
Zamel R
Waddell TK
Cypel M
Keshavjee S
Pokaż więcej
Źródło :
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons [Am J Transplant] 2014 Jun; Vol. 14 (6), pp. 1425-32. Date of Electronic Publication: 2014 May 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Lung Transplantation*
Pulmonary Alveoli/*metabolism
S100 Proteins/*metabolism
Adult ; Aged ; Bronchoalveolar Lavage Fluid ; Female ; Humans ; Male ; Middle Aged
Czasopismo naukowe
Tytuł :
Pretransplant Aspergillus colonization of cystic fibrosis patients and the incidence of post-lung transplant invasive aspergillosis.
Autorzy :
Luong ML; 1 Division of Infectious Diseases, Department of Medicine, University of Toronto, University Health Network, Toronto, Ontario, Canada. 2 Division of Respirology, Toronto Lung Transplant Program, University of Toronto, University Health Network, Toronto, Ontario, Canada. 3 Adult Cystic Fibrosis Centre and Department of Respiratory Medicine, University of Toronto, St Michael's Hospital, Toronto, Canada. 4 Division of Infectious Diseases, Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada. 5 Division of Thoracic Surgery, Toronto Lung Transplant Program, University of Toronto, University Health Network, Toronto, Ontario, Canada. 6 University of Toronto, Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, Canada. 7 Address correspondence to: Shahid Husain, M.D., Division of Infectious Diseases, Department of Medicine, University of Toronto, Toronto General Hospital, NCSB, 11th floor, 11c-1269, 585 University Avenue, Toronto, ON, Canada M5G 2N2.
Chaparro C
Stephenson A
Rotstein C
Singer LG
Waters V
Azad S
Keshavjee S
Tullis E
Husain S
Pokaż więcej
Źródło :
Transplantation [Transplantation] 2014 Feb 15; Vol. 97 (3), pp. 351-7.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Aspergillus/*pathogenicity
Cystic Fibrosis/*complications
Cystic Fibrosis/*microbiology
Invasive Pulmonary Aspergillosis/*complications
Lung Transplantation/*methods
Adult ; Antifungal Agents/therapeutic use ; Bronchoalveolar Lavage Fluid/microbiology ; Female ; Humans ; Immunosuppressive Agents/adverse effects ; Incidence ; Invasive Pulmonary Aspergillosis/epidemiology ; Male ; Postoperative Complications ; Retrospective Studies ; Risk Factors ; Sputum/microbiology ; Time Factors
Czasopismo naukowe
Tytuł :
Impact of cytokine expression in the pre-implanted donor lung on the development of chronic lung allograft dysfunction subtypes.
Autorzy :
Saito T; Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada; Department of Thoracic and Cardiovascular Surgery, Kansai Medical University, Hirakara, Japan.
Takahashi H
Kaneda H
Binnie M
Azad S
Sato M
Waddell TK
Cypel M
Liu M
Keshavjee S
Pokaż więcej
Źródło :
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons [Am J Transplant] 2013 Dec; Vol. 13 (12), pp. 3192-201. Date of Electronic Publication: 2013 Oct 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Lung Transplantation*
Bronchiolitis Obliterans/*therapy
Interleukin-6/*metabolism
Lung/*metabolism
Primary Graft Dysfunction/*etiology
Primary Graft Dysfunction/*metabolism
Adult ; Biopsy ; Bronchiolitis Obliterans/metabolism ; Cytokines/metabolism ; Female ; Follow-Up Studies ; Gene Expression Regulation ; Graft Rejection/blood ; Humans ; Male ; Middle Aged ; Proportional Hazards Models ; Retrospective Studies ; Time Factors ; Tissue Donors
Czasopismo naukowe
Tytuł :
Risk factors for voriconazole hepatotoxicity at 12 weeks in lung transplant recipients.
Autorzy :
Luong ML; Department of Medicine, Division of Infectious Diseases, University of Toronto, Toronto, Ontario, Canada.
Hosseini-Moghaddam SM
Singer LG
Chaparro C
Azad S
Lazar N
Boutros PC
Keshavjee S
Rotstein C
Husain S
Pokaż więcej
Źródło :
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons [Am J Transplant] 2012 Jul; Vol. 12 (7), pp. 1929-35. Date of Electronic Publication: 2012 Apr 05.
Typ publikacji :
Journal Article
MeSH Terms :
Lung Transplantation*
Antifungal Agents/*adverse effects
Liver/*drug effects
Pyrimidines/*adverse effects
Triazoles/*adverse effects
Adolescent ; Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Risk Factors ; Voriconazole ; Young Adult
Czasopismo naukowe

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