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Tytuł :
HSP70, a Novel Regulatory Molecule in B Cell-Mediated Suppression of Autoimmune Diseases.
Autorzy :
Wang L; Department of Immunology, School of Basic Medical Sciences, and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China; Department of Endocrinology and Metabolism, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China; Biotherapy Research Center, Fudan University, Shanghai 200032, China.
Fu Y; Department of Immunology, School of Basic Medical Sciences, and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China.
Yu B; Department of Immunology, School of Basic Medical Sciences, and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China.
Jiang X; Department of Immunology, School of Basic Medical Sciences, and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China.
Liu H; Department of Gastroenterology, Zhongshan Hospital, Fudan University, Shanghai, China.
Liu J; Department of Endocrinology and Metabolism, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.
Zha B; Department of Endocrinology and Metabolism, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China. Electronic address: .
Chu Y; Department of Immunology, School of Basic Medical Sciences, and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China; Biotherapy Research Center, Fudan University, Shanghai 200032, China. Electronic address: .
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Źródło :
Journal of molecular biology [J Mol Biol] 2021 Jan 08; Vol. 433 (1), pp. 166634. Date of Electronic Publication: 2020 Aug 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Susceptibility*
Immunomodulation*
Autoimmune Diseases/*etiology
Autoimmune Diseases/*metabolism
B-Lymphocytes/*immunology
B-Lymphocytes/*metabolism
HSP70 Heat-Shock Proteins/*metabolism
Adoptive Transfer ; Adult ; Aged ; Animals ; Autoimmune Diseases/diagnosis ; Autoimmune Diseases/therapy ; B-Lymphocytes, Regulatory/immunology ; B-Lymphocytes, Regulatory/metabolism ; Colitis/diagnosis ; Colitis/etiology ; Colitis/metabolism ; Colitis/therapy ; Cytokines/antagonists & inhibitors ; Cytokines/metabolism ; Dextran Sulfate/adverse effects ; Disease Models, Animal ; Female ; Gene Expression Profiling ; HSP70 Heat-Shock Proteins/genetics ; Humans ; Immunohistochemistry ; Immunophenotyping ; Male ; Mice ; Mice, Knockout ; Mice, Transgenic ; Middle Aged
Czasopismo naukowe
Tytuł :
B cells from Patients with Rheumatoid Arthritis Show Conserved CD39-Mediated Regulatory Function and increased CD39 Expression After Positive Response to Therapy.
Autorzy :
Zacca ER; Laboratorio de Inmunología. Hospital Nacional de Clínicas (HNC), Universidad Nacional de Córdoba (UNC), Córdoba, Argentina.
Amezcua Vesely MC; Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET), Facultad de Ciencias Químicas, UNC, Córdoba, Argentina.
Ferrero PV; Laboratorio de Inmunología. Hospital Nacional de Clínicas (HNC), Universidad Nacional de Córdoba (UNC), Córdoba, Argentina.
Acosta CDV; Laboratorio de Inmunología. Hospital Nacional de Clínicas (HNC), Universidad Nacional de Córdoba (UNC), Córdoba, Argentina.
Ponce NE; Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET), Facultad de Ciencias Químicas, UNC, Córdoba, Argentina.
Bossio SN; Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET), Facultad de Ciencias Químicas, UNC, Córdoba, Argentina.
Mussano E; Servicio de Reumatología. HNC, UNC, Córdoba, Argentina.
Onetti L; Servicio de Reumatología. HNC, UNC, Córdoba, Argentina.
Cadile I; Servicio de Reumatología. HNC, UNC, Córdoba, Argentina.
Acosta Rodríguez EV; Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET), Facultad de Ciencias Químicas, UNC, Córdoba, Argentina.
Montes CL; Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET), Facultad de Ciencias Químicas, UNC, Córdoba, Argentina.
Gruppi A; Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET), Facultad de Ciencias Químicas, UNC, Córdoba, Argentina. Electronic address: .
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Źródło :
Journal of molecular biology [J Mol Biol] 2021 Jan 08; Vol. 433 (1), pp. 166687. Date of Electronic Publication: 2020 Oct 22.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunomodulation*
Apyrase/*metabolism
Arthritis, Rheumatoid/*immunology
Arthritis, Rheumatoid/*metabolism
B-Lymphocytes/*immunology
B-Lymphocytes/*metabolism
Adenosine/metabolism ; Apyrase/genetics ; Arthritis, Rheumatoid/pathology ; Arthritis, Rheumatoid/therapy ; B-Lymphocytes, Regulatory/immunology ; B-Lymphocytes, Regulatory/metabolism ; Case-Control Studies ; Cytokines/biosynthesis ; Disease Management ; Disease Susceptibility ; Gene Expression ; Humans ; Lymphocyte Activation ; Lymphocyte Count ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Purification of Murine IL-10 B Cells for Analyses of Biological Functions and Transcriptomics.
Autorzy :
Sun J; Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-Sen University, Guangzhou, China. .
Basu U; Department of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA. .
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2270, pp. 307-321.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
B-Lymphocytes, Regulatory/*metabolism
Cell Separation/*methods
Gene Expression Profiling/*methods
Animals ; Antigens, CD19/immunology ; B-Lymphocyte Subsets/cytology ; B-Lymphocyte Subsets/metabolism ; B-Lymphocytes/cytology ; B-Lymphocytes/metabolism ; B-Lymphocytes, Regulatory/cytology ; Cell Lineage/genetics ; Female ; Interleukin-10/immunology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Oligonucleotide Array Sequence Analysis/methods ; Transcriptome/genetics
Czasopismo naukowe
Tytuł :
New Method for the Expansion of Highly Purified Human Regulatory Granzyme B-Expressing B Cells.
Autorzy :
Chesneau M; CHU Nantes, Université de Nantes, Inserm, Centre de Recherche en Transplantation et Immunologie, UMR 1064, ITUN, Nantes, France.; Labex IGO, Nantes, France.
Le Mai H; CHU Nantes, Université de Nantes, Inserm, Centre de Recherche en Transplantation et Immunologie, UMR 1064, ITUN, Nantes, France.; Labex IGO, Nantes, France.
Brouard S; CHU Nantes, Université de Nantes, Inserm, Centre de Recherche en Transplantation et Immunologie, UMR 1064, ITUN, Nantes, France. .; Labex IGO, Nantes, France. .; Centre d'Investigation Clinique en Biothérapie, Centre de ressources biologiques (CRB), Nantes, France. .
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2270, pp. 203-216.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
B-Lymphocytes, Regulatory/*immunology
Cell Culture Techniques/*methods
Granzymes/*isolation & purification
Apoptosis/immunology ; B-Lymphocytes/immunology ; B-Lymphocytes/metabolism ; B-Lymphocytes, Regulatory/metabolism ; Cell Proliferation ; Granzymes/immunology ; Granzymes/metabolism ; Humans ; Lymphocyte Activation ; T-Lymphocytes, Cytotoxic/immunology
Czasopismo naukowe
Tytuł :
IL-35 Detection in B Cells at the mRNA and Protein Level.
Autorzy :
Mirlekar B; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
Michaud D; Department of Cell Biology and Physiology, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
Pylayeva-Gupta Y; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA. .; Department of Genetics, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA. .
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2270, pp. 125-147.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
B-Lymphocytes/*cytology
Flow Cytometry/*methods
Interleukins/*analysis
Animals ; B-Lymphocyte Subsets/cytology ; B-Lymphocyte Subsets/immunology ; B-Lymphocytes/immunology ; B-Lymphocytes, Regulatory/immunology ; Cytokines/metabolism ; Enzyme-Linked Immunosorbent Assay/methods ; Humans ; Interleukin-10/immunology ; Interleukins/blood ; Mice ; RNA, Messenger/analysis ; RNA, Messenger/genetics ; Reverse Transcriptase Polymerase Chain Reaction/methods
Czasopismo naukowe
Tytuł :
Analysis of Regulatory B Cells in Experimental Autoimmune Uveitis.
Autorzy :
Choi JK; Molecular Immunology Section, Laboratory of Immunology, National Eye Institute (NEI), National Institutes of Health, Bethesda, MD, USA.; Department of Immunology, Jeonbuk National University Medical School, Jeonju, Jeonbuk, Republic of Korea.
Egwuagu CE; Molecular Immunology Section, Laboratory of Immunology, National Eye Institute (NEI), National Institutes of Health, Bethesda, MD, USA. .
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2270, pp. 437-450.
Typ publikacji :
Journal Article
MeSH Terms :
B-Lymphocytes, Regulatory/*pathology
Uveitis/*immunology
Uveitis/*therapy
Adoptive Transfer ; Animals ; Autoimmune Diseases/immunology ; B-Lymphocytes/cytology ; B-Lymphocytes/immunology ; B-Lymphocytes, Regulatory/cytology ; B-Lymphocytes, Regulatory/immunology ; Central Nervous System Diseases ; Disease Models, Animal ; Female ; Inflammation/pathology ; Interleukin-10/immunology ; Male ; Mice ; Mice, Inbred NOD ; T-Lymphocytes, Regulatory/immunology ; Uveitis/metabolism
Czasopismo naukowe
Tytuł :
Methods to Study the Transcriptome of Regulatory B Cells.
Autorzy :
Maho-Vaillant M; INSERM U1234, Normandy University, Rouen, France.; Dermatology Department, Rouen University Hospital, Rouen, France.
Calbo S; INSERM U1234, Normandy University, Rouen, France. .
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2270, pp. 295-305.
Typ publikacji :
Journal Article
MeSH Terms :
B-Lymphocytes, Regulatory/*metabolism
Gene Expression Profiling/*methods
Transcriptome/*genetics
Animals ; B-Lymphocyte Subsets/cytology ; B-Lymphocyte Subsets/metabolism ; B-Lymphocytes/cytology ; B-Lymphocytes/metabolism ; B-Lymphocytes, Regulatory/cytology ; Cell Lineage/genetics ; Humans ; Mice ; Oligonucleotide Array Sequence Analysis/methods ; Real-Time Polymerase Chain Reaction/methods
Czasopismo naukowe
Tytuł :
Regulatory B Cells in Type 1 Diabetes.
Autorzy :
Boldison J; Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, UK. .
Da Rosa LC; Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, UK.
Wong FS; Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, UK.
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2270, pp. 419-435.
Typ publikacji :
Journal Article
MeSH Terms :
B-Lymphocytes, Regulatory/*pathology
Diabetes Mellitus, Type 1/*immunology
Animals ; Antibodies, Monoclonal/metabolism ; Antigens, CD20/metabolism ; Autoimmune Diseases/immunology ; B-Lymphocytes/cytology ; B-Lymphocytes/immunology ; B-Lymphocytes, Regulatory/cytology ; B-Lymphocytes, Regulatory/immunology ; Diabetes Mellitus, Type 1/metabolism ; Disease Models, Animal ; Female ; Inflammation/pathology ; Insulin/metabolism ; Insulin-Secreting Cells/metabolism ; Islets of Langerhans/metabolism ; Male ; Mice ; Mice, Inbred NOD
Czasopismo naukowe
Tytuł :
Engineering antibody therapies for protective immunity.
Autorzy :
Lam N; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY.
Farber DL; Department of Surgery, Columbia University Irving Medical Center, New York, NY; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY. Electronic address: .
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Źródło :
The Journal of thoracic and cardiovascular surgery [J Thorac Cardiovasc Surg] 2021 Apr; Vol. 161 (4), pp. 1358-1361. Date of Electronic Publication: 2020 Jun 24.
Typ publikacji :
Editorial
MeSH Terms :
Antibodies*/genetics
Antibodies*/immunology
Antibodies*/metabolism
B-Lymphocytes*/immunology
B-Lymphocytes*/metabolism
Biological Therapy*
Cell Engineering*
Protein Engineering*
COVID-19/therapy ; Communicable Disease Control ; Communicable Diseases/immunology ; Humans ; Immunization, Passive
SCR Protocol :
COVID-19 serotherapy
Opinia redakcyjna
Tytuł :
Extremely potent human monoclonal antibodies from COVID-19 convalescent patients.
Autorzy :
Andreano E; Monoclonal Antibody Discovery (MAD) Lab, Fondazione Toscana Life Sciences, Siena, Italy.
Nicastri E; National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, Rome, Italy.
Paciello I; Monoclonal Antibody Discovery (MAD) Lab, Fondazione Toscana Life Sciences, Siena, Italy.
Pileri P; Monoclonal Antibody Discovery (MAD) Lab, Fondazione Toscana Life Sciences, Siena, Italy.
Manganaro N; Monoclonal Antibody Discovery (MAD) Lab, Fondazione Toscana Life Sciences, Siena, Italy.
Piccini G; VisMederi S.r.l, Siena, Italy.
Manenti A; VisMederi S.r.l, Siena, Italy; VisMederi Research S.r.l., Siena, Italy.
Pantano E; Monoclonal Antibody Discovery (MAD) Lab, Fondazione Toscana Life Sciences, Siena, Italy.
Kabanova A; Monoclonal Antibody Discovery (MAD) Lab, Fondazione Toscana Life Sciences, Siena, Italy; Tumour Immunology Unit, Fondazione Toscana Life Sciences, Siena, Italy.
Troisi M; Monoclonal Antibody Discovery (MAD) Lab, Fondazione Toscana Life Sciences, Siena, Italy; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Siena, Italy.
Vacca F; Monoclonal Antibody Discovery (MAD) Lab, Fondazione Toscana Life Sciences, Siena, Italy; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Siena, Italy.
Cardamone D; Monoclonal Antibody Discovery (MAD) Lab, Fondazione Toscana Life Sciences, Siena, Italy; University of Turin, Turin, Italy.
De Santi C; Monoclonal Antibody Discovery (MAD) Lab, Fondazione Toscana Life Sciences, Siena, Italy.
Torres JL; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Ozorowski G; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Benincasa L; VisMederi Research S.r.l., Siena, Italy.
Jang H; Center for Vaccines and Immunology, University of Georgia, Athens, GA 30602, USA.
Di Genova C; Viral Pseudotype Unit, Medway School of Pharmacy, University of Kent, Chatham, UK.
Depau L; MedBiotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, Siena, Italy.
Brunetti J; MedBiotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, Siena, Italy.
Agrati C; National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, Rome, Italy.
Capobianchi MR; National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, Rome, Italy.
Castilletti C; National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, Rome, Italy.
Emiliozzi A; Department of Medical Biotechnologies, University of Siena, Siena, Italy; Department of Medical Sciences, Infectious and Tropical Diseases Unit, University Hospital of Siena, Siena, Italy.
Fabbiani M; Department of Medical Sciences, Infectious and Tropical Diseases Unit, University Hospital of Siena, Siena, Italy.
Montagnani F; Department of Medical Biotechnologies, University of Siena, Siena, Italy; Department of Medical Sciences, Infectious and Tropical Diseases Unit, University Hospital of Siena, Siena, Italy.
Bracci L; MedBiotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, Siena, Italy.
Sautto G; Center for Vaccines and Immunology, University of Georgia, Athens, GA 30602, USA.
Ross TM; Center for Vaccines and Immunology, University of Georgia, Athens, GA 30602, USA; Department of Infectious Diseases, University of Georgia, Athens, GA 30602, USA.
Montomoli E; VisMederi S.r.l, Siena, Italy; VisMederi Research S.r.l., Siena, Italy; Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy.
Temperton N; Viral Pseudotype Unit, Medway School of Pharmacy, University of Kent, Chatham, UK.
Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Sala C; Monoclonal Antibody Discovery (MAD) Lab, Fondazione Toscana Life Sciences, Siena, Italy.
Ippolito G; National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, Rome, Italy.
Rappuoli R; Monoclonal Antibody Discovery (MAD) Lab, Fondazione Toscana Life Sciences, Siena, Italy; Faculty of Medicine, Imperial College, London, UK. Electronic address: .
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Źródło :
Cell [Cell] 2021 Apr 01; Vol. 184 (7), pp. 1821-1835.e16. Date of Electronic Publication: 2021 Feb 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
COVID-19*/immunology
COVID-19*/prevention & control
COVID-19*/therapy
Convalescence*
Antibodies, Monoclonal/*administration & dosage
Antibodies, Neutralizing/*administration & dosage
Antibodies, Viral/*administration & dosage
B-Lymphocytes/*immunology
3T3 Cells ; Animals ; Antibodies, Monoclonal/isolation & purification ; Antibodies, Neutralizing/isolation & purification ; Antibodies, Viral/isolation & purification ; B-Lymphocytes/cytology ; Chlorocebus aethiops ; Disease Models, Animal ; Female ; HEK293 Cells ; Humans ; Immunoglobulin Fc Fragments/immunology ; Male ; Mice ; Spike Glycoprotein, Coronavirus/immunology ; Vero Cells
Czasopismo naukowe
Tytuł :
Anti-interleukin-21 antibody and liraglutide for the preservation of β-cell function in adults with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled, phase 2 trial.
Autorzy :
von Herrath M; Novo Nordisk A/S, Søborg, Denmark.
Bain SC; Swansea University Medical School, Swansea, UK.
Bode B; Atlanta Diabetes Associates, Atlanta, GA, USA; Emory University School of Medicine, Atlanta, GA, USA.
Clausen JO; Novo Nordisk A/S, Søborg, Denmark.
Coppieters K; Novo Nordisk A/S, Måløv, Denmark.
Gaysina L; Kazan Federal University, Kazan, Russia.
Gumprecht J; Medical University of Silesia, Katowice, Poland.
Hansen TK; Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark.
Mathieu C; Clinical and Experimental Endocrinology, UZ Gasthuisberg, University of Leuven, Leuven, Belgium.
Morales C; Endocrinology and Nutrition Department, Virgen Macarena Hospital, Seville, Spain.
Mosenzon O; Diabetes Unit, Department of Endocrinology and Metabolism, Hadassah Medical Centre, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Segel S; Novo Nordisk A/S, Aalborg, Denmark.
Tsoukas G; Department of Medicine, McGill University, Montreal, QC, Canada.
Pieber TR; Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Graz, Austria. Electronic address: .
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Corporate Authors :
Anti-IL-21–liraglutide Study Group investigators and contributors
Źródło :
The lancet. Diabetes & endocrinology [Lancet Diabetes Endocrinol] 2021 Apr; Vol. 9 (4), pp. 212-224. Date of Electronic Publication: 2021 Mar 01.
Typ publikacji :
Clinical Trial, Phase II; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Monoclonal/*administration & dosage
B-Lymphocytes/*physiology
Diabetes Mellitus, Type 1/*drug therapy
Hypoglycemic Agents/*administration & dosage
Interleukins/*antagonists & inhibitors
Liraglutide/*administration & dosage
Adult ; B-Lymphocytes/drug effects ; Diabetes Mellitus, Type 1/blood ; Diabetes Mellitus, Type 1/diagnosis ; Double-Blind Method ; Drug Therapy, Combination ; Female ; Follow-Up Studies ; Humans ; Interleukins/blood ; Male ; Young Adult
Czasopismo naukowe
Tytuł :
Super-enhancers for RUNX3 are required for cell proliferation in EBV-infected B cell lines.
Autorzy :
Hosoi H; Cancer Science Institute of Singapore, National University of Singapore, Singapore; Department of Hematology/Oncology, Wakayama Medical University, Wakayama, Japan.
Niibori-Nambu A; Cancer Science Institute of Singapore, National University of Singapore, Singapore; Department of Tumor Genetics and Biology, Graduate School of Medical Sciences, Institute of Life Sciences, Kumamoto University, Kumamoto, Japan.
Nah GSS; Cancer Science Institute of Singapore, National University of Singapore, Singapore.
Bahirvani AG; Cancer Science Institute of Singapore, National University of Singapore, Singapore.
Mok MMH; Cancer Science Institute of Singapore, National University of Singapore, Singapore.
Sanda T; Cancer Science Institute of Singapore, National University of Singapore, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Kumar AP; Cancer Science Institute of Singapore, National University of Singapore, Singapore; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Cancer Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Tenen DG; Cancer Science Institute of Singapore, National University of Singapore, Singapore; Harvard Stem Cell Institute, Harvard Medical School, Boston, MA, USA.
Ito Y; Cancer Science Institute of Singapore, National University of Singapore, Singapore.
Sonoki T; Department of Hematology/Oncology, Wakayama Medical University, Wakayama, Japan. Electronic address: .
Osato M; Cancer Science Institute of Singapore, National University of Singapore, Singapore; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; International Research Center for Medical Sciences, Kumamoto University, Japan. Electronic address: .
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Źródło :
Gene [Gene] 2021 Mar 30; Vol. 774, pp. 145421. Date of Electronic Publication: 2021 Jan 12.
Typ publikacji :
Journal Article
MeSH Terms :
Enhancer Elements, Genetic*
B-Lymphocytes/*virology
Cell Proliferation/*genetics
Core Binding Factor Alpha 3 Subunit/*genetics
Herpesvirus 4, Human/*physiology
Azepines/pharmacology ; B-Lymphocytes/cytology ; Burkitt Lymphoma/genetics ; Burkitt Lymphoma/virology ; CRISPR-Cas Systems ; Cell Line ; Cell Line, Tumor ; Cell Proliferation/drug effects ; G1 Phase/drug effects ; Gene Expression Regulation/drug effects ; Genes, myc ; Humans ; Protein Domains ; Proteins/antagonists & inhibitors ; Proteins/metabolism ; Triazoles/pharmacology
Czasopismo naukowe
Tytuł :
The Interaction of Human and Epstein-Barr Virus miRNAs with Multiple Sclerosis Risk Loci.
Autorzy :
Afrasiabi A; Systems Biology and Health Data Analytics Lab, The Graduate School of Biomedical Engineering, UNSW Sydney, Sydney, NSW 2052, Australia.; EBV Molecular Lab, Centre for Immunology and Allergy Research, Westmead Institute for Medical Research, University of Sydney, Westmead, NSW 2145, Australia.
Fewings NL; EBV Molecular Lab, Centre for Immunology and Allergy Research, Westmead Institute for Medical Research, University of Sydney, Westmead, NSW 2145, Australia.
Schibeci SD; EBV Molecular Lab, Centre for Immunology and Allergy Research, Westmead Institute for Medical Research, University of Sydney, Westmead, NSW 2145, Australia.
Keane JT; EBV Molecular Lab, Centre for Immunology and Allergy Research, Westmead Institute for Medical Research, University of Sydney, Westmead, NSW 2145, Australia.
Booth DR; EBV Molecular Lab, Centre for Immunology and Allergy Research, Westmead Institute for Medical Research, University of Sydney, Westmead, NSW 2145, Australia.
Parnell GP; EBV Molecular Lab, Centre for Immunology and Allergy Research, Westmead Institute for Medical Research, University of Sydney, Westmead, NSW 2145, Australia.
Swaminathan S; EBV Molecular Lab, Centre for Immunology and Allergy Research, Westmead Institute for Medical Research, University of Sydney, Westmead, NSW 2145, Australia.; Department of Medicine, Western Sydney University, Sydney, NSW 2560, Australia.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Mar 13; Vol. 22 (6). Date of Electronic Publication: 2021 Mar 13.
Typ publikacji :
Journal Article
MeSH Terms :
Genetic Loci*
B-Lymphocytes/*virology
Host-Pathogen Interactions/*genetics
MicroRNAs/*genetics
RNA, Messenger/*genetics
RNA-Binding Proteins/*genetics
Alleles ; B-Lymphocytes/immunology ; Base Sequence ; Gene Expression Regulation ; Host-Pathogen Interactions/immunology ; Humans ; Interferon-gamma/genetics ; Interferon-gamma/immunology ; MicroRNAs/immunology ; Models, Biological ; Multiple Sclerosis/genetics ; Multiple Sclerosis/immunology ; Multiple Sclerosis/pathology ; Multiple Sclerosis/virology ; Polymorphism, Single Nucleotide ; Primary Cell Culture ; RNA, Messenger/immunology ; RNA-Binding Proteins/immunology ; Signal Transduction
Czasopismo naukowe
Tytuł :
Pertussis Toxin Inhibits Encephalitogenic T-Cell Infiltration and Promotes a B-Cell-Driven Disease during Th17-EAE.
Autorzy :
Maria Z; Department of Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.
Turner E; Department of Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.; Department of Animal and Food Sciences, Oklahoma State University, Stillwater, OK 74078, USA.
Agasing A; Department of Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.
Kumar G; Department of Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.
Axtell RC; Department of Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Mar 13; Vol. 22 (6). Date of Electronic Publication: 2021 Mar 13.
Typ publikacji :
Journal Article
MeSH Terms :
B-Lymphocytes/*pathology
Encephalomyelitis, Autoimmune, Experimental/*pathology
Pertussis Toxin/*administration & dosage
Th17 Cells/*pathology
Adoptive Transfer/methods ; Animals ; B-Lymphocytes/immunology ; Cell Movement/immunology ; Encephalomyelitis, Autoimmune, Experimental/chemically induced ; Encephalomyelitis, Autoimmune, Experimental/immunology ; Encephalomyelitis, Autoimmune, Experimental/mortality ; Female ; Humans ; Kaplan-Meier Estimate ; Mice ; Mice, Inbred C57BL ; Multiple Sclerosis/immunology ; Multiple Sclerosis/pathology ; Myelin-Oligodendrocyte Glycoprotein/administration & dosage ; Severity of Illness Index ; Th17 Cells/immunology ; Th17 Cells/transplantation
Czasopismo naukowe
Tytuł :
Complement-Opsonized Nano-Carriers Are Bound by Dendritic Cells (DC) via Complement Receptor (CR)3, and by B Cell Subpopulations via CR-1/2, and Affect the Activation of DC and B-1 Cells.
Autorzy :
Bednarczyk M; Department of Dermatology, University Medical Center Mainz, Langenbeckstraße 1, 55131 Mainz, Germany.
Medina-Montano C; Department of Dermatology, University Medical Center Mainz, Langenbeckstraße 1, 55131 Mainz, Germany.
Fittler FJ; Department of Dermatology, University Medical Center Mainz, Langenbeckstraße 1, 55131 Mainz, Germany.
Stege H; Department of Dermatology, University Medical Center Mainz, Langenbeckstraße 1, 55131 Mainz, Germany.
Roskamp M; Miltenyi Biotec GmbH, Friedrich-Ebert-Strasse 68, 51429 Bergisch Gladbach, Germany.
Kuske M; Department of Dermatology, University Medical Center Mainz, Langenbeckstraße 1, 55131 Mainz, Germany.
Langer C; Miltenyi Biotec GmbH, Friedrich-Ebert-Strasse 68, 51429 Bergisch Gladbach, Germany.
Vahldieck M; Miltenyi Biotec GmbH, Friedrich-Ebert-Strasse 68, 51429 Bergisch Gladbach, Germany.
Montermann E; Department of Dermatology, University Medical Center Mainz, Langenbeckstraße 1, 55131 Mainz, Germany.
Tubbe I; Department of Dermatology, University Medical Center Mainz, Langenbeckstraße 1, 55131 Mainz, Germany.
Röhrig N; Department of Dermatology, University Medical Center Mainz, Langenbeckstraße 1, 55131 Mainz, Germany.
Dzionek A; Miltenyi Biotec GmbH, Friedrich-Ebert-Strasse 68, 51429 Bergisch Gladbach, Germany.
Grabbe S; Department of Dermatology, University Medical Center Mainz, Langenbeckstraße 1, 55131 Mainz, Germany.
Bros M; Department of Dermatology, University Medical Center Mainz, Langenbeckstraße 1, 55131 Mainz, Germany.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Mar 11; Vol. 22 (6). Date of Electronic Publication: 2021 Mar 11.
Typ publikacji :
Journal Article
MeSH Terms :
B-Lymphocyte Subsets/*immunology
B-Lymphocytes/*immunology
CD11b Antigen/*immunology
Complement System Proteins/*immunology
Dendritic Cells/*immunology
Receptors, Complement/*immunology
Animals ; B-Lymphocyte Subsets/metabolism ; B-Lymphocytes/metabolism ; CD11b Antigen/genetics ; CD11b Antigen/metabolism ; Cells, Cultured ; Complement Activation/immunology ; Complement System Proteins/metabolism ; Dendritic Cells/metabolism ; Dextrans/chemistry ; Drug Carriers/chemistry ; Humans ; Lymphocyte Activation/immunology ; Mice, Inbred C57BL ; Mice, Knockout ; Nanoparticles/chemistry ; Opsonin Proteins/immunology ; Opsonin Proteins/metabolism ; Phagocytosis/immunology ; Receptors, Complement/metabolism
Czasopismo naukowe
Tytuł :
Immune Memory in Mild COVID-19 Patients and Unexposed Donors Reveals Persistent T Cell Responses After SARS-CoV-2 Infection.
Autorzy :
Ansari A; Vaccine Immunology Laboratory, National Institute of Immunology, New Delhi, India.
Arya R; Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India.
Sachan S; Vaccine Immunology Laboratory, National Institute of Immunology, New Delhi, India.
Jha SN; Vaccine Immunology Laboratory, National Institute of Immunology, New Delhi, India.
Kalia A; Vaccine Immunology Laboratory, National Institute of Immunology, New Delhi, India.
Lall A; Department of Transfusion Medicine, All India Institute of Medical Sciences, New Delhi, India.
Sette A; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, United States.; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego, La Jolla, CA, United States.
Grifoni A; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, United States.
Weiskopf D; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, United States.
Coshic P; Department of Transfusion Medicine, All India Institute of Medical Sciences, New Delhi, India.
Sharma A; Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India.
Gupta N; Vaccine Immunology Laboratory, National Institute of Immunology, New Delhi, India.
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Źródło :
Frontiers in immunology [Front Immunol] 2021 Mar 11; Vol. 12, pp. 636768. Date of Electronic Publication: 2021 Mar 11 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunologic Memory*
B-Lymphocytes/*immunology
CD4-Positive T-Lymphocytes/*immunology
COVID-19/*immunology
SARS-CoV-2/*immunology
Spike Glycoprotein, Coronavirus/*immunology
Adult ; Antibodies, Neutralizing/blood ; Antibodies, Viral/blood ; B-Lymphocytes/virology ; CD4-Positive T-Lymphocytes/virology ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/virology ; COVID-19/blood ; COVID-19/diagnosis ; COVID-19/virology ; Case-Control Studies ; Female ; Humans ; Immunity, Cellular ; Male ; Middle Aged ; Time Factors ; Young Adult
Czasopismo naukowe
Tytuł :
The dichotomous and incomplete adaptive immunity in COVID-19 patients with different disease severity.
Autorzy :
Gao L; Institute of Immunology, Third Military Medical University, Chongqing, China.
Zhou J; Institute of Immunology, Third Military Medical University, Chongqing, China.
Yang S; Chongqing Public Health Medical Center, Chongqing, China.
Wang L; Institute of Immunology, Third Military Medical University, Chongqing, China.
Chen X; Institute of Immunology, Third Military Medical University, Chongqing, China.
Yang Y; Institute of Immunology, Third Military Medical University, Chongqing, China.
Li R; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, Heilongjiang, China.; College of Veterinary Medicine, Northeast Agricultural University, Harbin, Heilongjiang, China.
Pan Z; Institute of Immunology, Third Military Medical University, Chongqing, China.
Zhao J; Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Li Z; Institute of Immunology, Third Military Medical University, Chongqing, China.
Huang Q; Cancer Center, The General Hospital of Western Theater Command, Chengdu, Sichuan, China.
Tang J; Institute of Immunology, Third Military Medical University, Chongqing, China.
Hu L; Institute of Immunology, Third Military Medical University, Chongqing, China.
Liu P; Comparative Immunology Research Center, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Zhang G; Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, China. .
Chen Y; Chongqing Public Health Medical Center, Chongqing, China. .
Ye L; Institute of Immunology, Third Military Medical University, Chongqing, China. .
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Źródło :
Signal transduction and targeted therapy [Signal Transduct Target Ther] 2021 Mar 08; Vol. 6 (1), pp. 113. Date of Electronic Publication: 2021 Mar 08.
Typ publikacji :
Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adaptive Immunity*
B-Lymphocytes/*immunology
CD8-Positive T-Lymphocytes/*immunology
COVID-19/*immunology
SARS-CoV-2/*immunology
Th1 Cells/*immunology
Adult ; B-Lymphocytes/pathology ; CD8-Positive T-Lymphocytes/pathology ; COVID-19/pathology ; Female ; Humans ; Male ; Severity of Illness Index ; Th1 Cells/pathology
Czasopismo naukowe
Tytuł :
Artemisinin attenuates IgM xenoantibody production via inhibition of T cell-independent marginal zone B cell proliferation.
Autorzy :
Liu L; Department of Traditional Chinese Medicine, The Fifth Affiliated Hospital, University of Sun Yat-sen, Zhuhai, P. R. China.
Zhao J; Department of Pharmacy, The Fifth Affiliated Hospital, University of Sun Yat-sen, Zhuhai, P. R. China.
Li A; Department of Traditional Chinese Medicine, The Fifth Affiliated Hospital, University of Sun Yat-sen, Zhuhai, P. R. China.
Yang X; Department of Traditional Chinese Medicine, The Fifth Affiliated Hospital, University of Sun Yat-sen, Zhuhai, P. R. China.
Sprangers B; Department of Microbiology and Immunology, Laboratory of Molecular Immunology (Rega institute), KU Leuven, Leuven, Belgium.
Li S; Department of Traditional Chinese Medicine, The Fifth Affiliated Hospital, University of Sun Yat-sen, Zhuhai, P. R. China.; Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital, University of Sun Yat-sen, Zhuhai, P. R. China.
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Źródło :
Journal of leukocyte biology [J Leukoc Biol] 2021 Mar; Vol. 109 (3), pp. 583-591. Date of Electronic Publication: 2020 Jun 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Heterophile/*biosynthesis
Artemisinins/*pharmacology
B-Lymphocytes/*cytology
Immunoglobulin M/*biosynthesis
T-Lymphocytes/*immunology
Animals ; Antibody Formation/drug effects ; Antigens, CD/metabolism ; B-Lymphocytes/drug effects ; Cell Proliferation/drug effects ; Interleukin-10/metabolism ; Lymphocyte Subsets/cytology ; Lymphocyte Subsets/drug effects ; Male ; Mice, Inbred BALB C ; Mice, Nude ; Spleen/immunology ; T-Lymphocytes/drug effects
Czasopismo naukowe
Tytuł :
il-10 Gene Locus DNA Methylation in Regulatory B Cells.
Autorzy :
Tonon S; Department of Medicine, University of Udine, Udine, Italy. .
Martinis E; Department of Medicine, University of Udine, Udine, Italy.
Pucillo CEM; Department of Medicine, University of Udine, Udine, Italy.
Mion F; Department of Medicine, University of Udine, Udine, Italy.
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2270, pp. 323-339.
Typ publikacji :
Journal Article; Review
MeSH Terms :
DNA Methylation*
B-Lymphocytes/*physiology
B-Lymphocytes, Regulatory/*metabolism
Interleukin-10/*genetics
Animals ; B-Lymphocytes/immunology ; B-Lymphocytes/metabolism ; B-Lymphocytes, Regulatory/immunology ; Cell Differentiation/genetics ; CpG Islands ; Cytokines/genetics ; Epigenesis, Genetic ; Epigenomics/methods ; Humans ; Interleukin-10/immunology ; Polymerase Chain Reaction/methods
Czasopismo naukowe
Tytuł :
The imbalance between regulatory and memory B cells accompanied by an increased number of circulating T-follicular helper cells in MOG-antibody-associated demyelination.
Autorzy :
Li X; Department of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Wulumuqi Zhong Road, Shanghai 200040, China; Department of Neurology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Wang L; Department of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Wulumuqi Zhong Road, Shanghai 200040, China.
Zhou L; Department of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Wulumuqi Zhong Road, Shanghai 200040, China.
ZhangBao J; Department of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Wulumuqi Zhong Road, Shanghai 200040, China.
Miao MZ; Department of Oral and Craniofacial Health Sciences, Adams School of Dentistry, University of North Carolina at Chapel Hill, NC, United States; Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Lu C; Department of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Wulumuqi Zhong Road, Shanghai 200040, China.
Lu J; Department of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Wulumuqi Zhong Road, Shanghai 200040, China.
Quan C; Department of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Wulumuqi Zhong Road, Shanghai 200040, China. Electronic address: .
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Źródło :
Multiple sclerosis and related disorders [Mult Scler Relat Disord] 2019 Nov; Vol. 36, pp. 101397. Date of Electronic Publication: 2019 Sep 16.
Typ publikacji :
Journal Article
MeSH Terms :
B-Lymphocytes*/immunology
T-Lymphocytes, Helper-Inducer*/immunology
Aquaporin 4/*immunology
Autoantibodies/*blood
Myelin-Oligodendrocyte Glycoprotein/*immunology
Neuromyelitis Optica/*immunology
Adolescent ; Adult ; Aged ; B-Lymphocytes, Regulatory/immunology ; Child ; Child, Preschool ; Female ; Humans ; Male ; Middle Aged ; Neuromyelitis Optica/blood ; Young Adult
Czasopismo naukowe

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