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Tytuł :
HSP70, a Novel Regulatory Molecule in B Cell-Mediated Suppression of Autoimmune Diseases.
Autorzy :
Wang L; Department of Immunology, School of Basic Medical Sciences, and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China; Department of Endocrinology and Metabolism, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China; Biotherapy Research Center, Fudan University, Shanghai 200032, China.
Fu Y; Department of Immunology, School of Basic Medical Sciences, and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China.
Yu B; Department of Immunology, School of Basic Medical Sciences, and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China.
Jiang X; Department of Immunology, School of Basic Medical Sciences, and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China.
Liu H; Department of Gastroenterology, Zhongshan Hospital, Fudan University, Shanghai, China.
Liu J; Department of Endocrinology and Metabolism, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.
Zha B; Department of Endocrinology and Metabolism, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China. Electronic address: .
Chu Y; Department of Immunology, School of Basic Medical Sciences, and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China; Biotherapy Research Center, Fudan University, Shanghai 200032, China. Electronic address: .
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Źródło :
Journal of molecular biology [J Mol Biol] 2021 Jan 08; Vol. 433 (1), pp. 166634. Date of Electronic Publication: 2020 Aug 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Susceptibility*
Immunomodulation*
Autoimmune Diseases/*etiology
Autoimmune Diseases/*metabolism
B-Lymphocytes/*immunology
B-Lymphocytes/*metabolism
HSP70 Heat-Shock Proteins/*metabolism
Adoptive Transfer ; Adult ; Aged ; Animals ; Autoimmune Diseases/diagnosis ; Autoimmune Diseases/therapy ; B-Lymphocytes, Regulatory/immunology ; B-Lymphocytes, Regulatory/metabolism ; Colitis/diagnosis ; Colitis/etiology ; Colitis/metabolism ; Colitis/therapy ; Cytokines/antagonists & inhibitors ; Cytokines/metabolism ; Dextran Sulfate/adverse effects ; Disease Models, Animal ; Female ; Gene Expression Profiling ; HSP70 Heat-Shock Proteins/genetics ; Humans ; Immunohistochemistry ; Immunophenotyping ; Male ; Mice ; Mice, Knockout ; Mice, Transgenic ; Middle Aged
Czasopismo naukowe
Tytuł :
B cells from Patients with Rheumatoid Arthritis Show Conserved CD39-Mediated Regulatory Function and increased CD39 Expression After Positive Response to Therapy.
Autorzy :
Zacca ER; Laboratorio de Inmunología. Hospital Nacional de Clínicas (HNC), Universidad Nacional de Córdoba (UNC), Córdoba, Argentina.
Amezcua Vesely MC; Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET), Facultad de Ciencias Químicas, UNC, Córdoba, Argentina.
Ferrero PV; Laboratorio de Inmunología. Hospital Nacional de Clínicas (HNC), Universidad Nacional de Córdoba (UNC), Córdoba, Argentina.
Acosta CDV; Laboratorio de Inmunología. Hospital Nacional de Clínicas (HNC), Universidad Nacional de Córdoba (UNC), Córdoba, Argentina.
Ponce NE; Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET), Facultad de Ciencias Químicas, UNC, Córdoba, Argentina.
Bossio SN; Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET), Facultad de Ciencias Químicas, UNC, Córdoba, Argentina.
Mussano E; Servicio de Reumatología. HNC, UNC, Córdoba, Argentina.
Onetti L; Servicio de Reumatología. HNC, UNC, Córdoba, Argentina.
Cadile I; Servicio de Reumatología. HNC, UNC, Córdoba, Argentina.
Acosta Rodríguez EV; Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET), Facultad de Ciencias Químicas, UNC, Córdoba, Argentina.
Montes CL; Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET), Facultad de Ciencias Químicas, UNC, Córdoba, Argentina.
Gruppi A; Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET), Facultad de Ciencias Químicas, UNC, Córdoba, Argentina. Electronic address: .
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Źródło :
Journal of molecular biology [J Mol Biol] 2021 Jan 08; Vol. 433 (1), pp. 166687. Date of Electronic Publication: 2020 Oct 22.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunomodulation*
Apyrase/*metabolism
Arthritis, Rheumatoid/*immunology
Arthritis, Rheumatoid/*metabolism
B-Lymphocytes/*immunology
B-Lymphocytes/*metabolism
Adenosine/metabolism ; Apyrase/genetics ; Arthritis, Rheumatoid/pathology ; Arthritis, Rheumatoid/therapy ; B-Lymphocytes, Regulatory/immunology ; B-Lymphocytes, Regulatory/metabolism ; Case-Control Studies ; Cytokines/biosynthesis ; Disease Management ; Disease Susceptibility ; Gene Expression ; Humans ; Lymphocyte Activation ; Lymphocyte Count ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Purification of Murine IL-10 B Cells for Analyses of Biological Functions and Transcriptomics.
Autorzy :
Sun J; Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-Sen University, Guangzhou, China. .
Basu U; Department of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA. .
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2270, pp. 307-321.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
B-Lymphocytes, Regulatory/*metabolism
Cell Separation/*methods
Gene Expression Profiling/*methods
Animals ; Antigens, CD19/immunology ; B-Lymphocyte Subsets/cytology ; B-Lymphocyte Subsets/metabolism ; B-Lymphocytes/cytology ; B-Lymphocytes/metabolism ; B-Lymphocytes, Regulatory/cytology ; Cell Lineage/genetics ; Female ; Interleukin-10/immunology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Oligonucleotide Array Sequence Analysis/methods ; Transcriptome/genetics
Czasopismo naukowe
Tytuł :
New Method for the Expansion of Highly Purified Human Regulatory Granzyme B-Expressing B Cells.
Autorzy :
Chesneau M; CHU Nantes, Université de Nantes, Inserm, Centre de Recherche en Transplantation et Immunologie, UMR 1064, ITUN, Nantes, France.; Labex IGO, Nantes, France.
Le Mai H; CHU Nantes, Université de Nantes, Inserm, Centre de Recherche en Transplantation et Immunologie, UMR 1064, ITUN, Nantes, France.; Labex IGO, Nantes, France.
Brouard S; CHU Nantes, Université de Nantes, Inserm, Centre de Recherche en Transplantation et Immunologie, UMR 1064, ITUN, Nantes, France. .; Labex IGO, Nantes, France. .; Centre d'Investigation Clinique en Biothérapie, Centre de ressources biologiques (CRB), Nantes, France. .
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2270, pp. 203-216.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
B-Lymphocytes, Regulatory/*immunology
Cell Culture Techniques/*methods
Granzymes/*isolation & purification
Apoptosis/immunology ; B-Lymphocytes/immunology ; B-Lymphocytes/metabolism ; B-Lymphocytes, Regulatory/metabolism ; Cell Proliferation ; Granzymes/immunology ; Granzymes/metabolism ; Humans ; Lymphocyte Activation ; T-Lymphocytes, Cytotoxic/immunology
Czasopismo naukowe
Tytuł :
IL-35 Detection in B Cells at the mRNA and Protein Level.
Autorzy :
Mirlekar B; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
Michaud D; Department of Cell Biology and Physiology, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
Pylayeva-Gupta Y; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA. .; Department of Genetics, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA. .
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2270, pp. 125-147.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
B-Lymphocytes/*cytology
Flow Cytometry/*methods
Interleukins/*analysis
Animals ; B-Lymphocyte Subsets/cytology ; B-Lymphocyte Subsets/immunology ; B-Lymphocytes/immunology ; B-Lymphocytes, Regulatory/immunology ; Cytokines/metabolism ; Enzyme-Linked Immunosorbent Assay/methods ; Humans ; Interleukin-10/immunology ; Interleukins/blood ; Mice ; RNA, Messenger/analysis ; RNA, Messenger/genetics ; Reverse Transcriptase Polymerase Chain Reaction/methods
Czasopismo naukowe
Tytuł :
Analysis of Regulatory B Cells in Experimental Autoimmune Uveitis.
Autorzy :
Choi JK; Molecular Immunology Section, Laboratory of Immunology, National Eye Institute (NEI), National Institutes of Health, Bethesda, MD, USA.; Department of Immunology, Jeonbuk National University Medical School, Jeonju, Jeonbuk, Republic of Korea.
Egwuagu CE; Molecular Immunology Section, Laboratory of Immunology, National Eye Institute (NEI), National Institutes of Health, Bethesda, MD, USA. .
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2270, pp. 437-450.
Typ publikacji :
Journal Article
MeSH Terms :
B-Lymphocytes, Regulatory/*pathology
Uveitis/*immunology
Uveitis/*therapy
Adoptive Transfer ; Animals ; Autoimmune Diseases/immunology ; B-Lymphocytes/cytology ; B-Lymphocytes/immunology ; B-Lymphocytes, Regulatory/cytology ; B-Lymphocytes, Regulatory/immunology ; Central Nervous System Diseases ; Disease Models, Animal ; Female ; Inflammation/pathology ; Interleukin-10/immunology ; Male ; Mice ; Mice, Inbred NOD ; T-Lymphocytes, Regulatory/immunology ; Uveitis/metabolism
Czasopismo naukowe
Tytuł :
Methods to Study the Transcriptome of Regulatory B Cells.
Autorzy :
Maho-Vaillant M; INSERM U1234, Normandy University, Rouen, France.; Dermatology Department, Rouen University Hospital, Rouen, France.
Calbo S; INSERM U1234, Normandy University, Rouen, France. .
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2270, pp. 295-305.
Typ publikacji :
Journal Article
MeSH Terms :
B-Lymphocytes, Regulatory/*metabolism
Gene Expression Profiling/*methods
Transcriptome/*genetics
Animals ; B-Lymphocyte Subsets/cytology ; B-Lymphocyte Subsets/metabolism ; B-Lymphocytes/cytology ; B-Lymphocytes/metabolism ; B-Lymphocytes, Regulatory/cytology ; Cell Lineage/genetics ; Humans ; Mice ; Oligonucleotide Array Sequence Analysis/methods ; Real-Time Polymerase Chain Reaction/methods
Czasopismo naukowe
Tytuł :
Regulatory B Cells in Type 1 Diabetes.
Autorzy :
Boldison J; Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, UK. .
Da Rosa LC; Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, UK.
Wong FS; Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, UK.
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2270, pp. 419-435.
Typ publikacji :
Journal Article
MeSH Terms :
B-Lymphocytes, Regulatory/*pathology
Diabetes Mellitus, Type 1/*immunology
Animals ; Antibodies, Monoclonal/metabolism ; Antigens, CD20/metabolism ; Autoimmune Diseases/immunology ; B-Lymphocytes/cytology ; B-Lymphocytes/immunology ; B-Lymphocytes, Regulatory/cytology ; B-Lymphocytes, Regulatory/immunology ; Diabetes Mellitus, Type 1/metabolism ; Disease Models, Animal ; Female ; Inflammation/pathology ; Insulin/metabolism ; Insulin-Secreting Cells/metabolism ; Islets of Langerhans/metabolism ; Male ; Mice ; Mice, Inbred NOD
Czasopismo naukowe
Tytuł :
Characterization of neutralizing versus binding antibodies and memory B cells in COVID-19 recovered individuals from India.
Autorzy :
Nayak K; ICGEB-Emory Vaccine Center, International Center for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India.
Gottimukkala K; ICGEB-Emory Vaccine Center, International Center for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India.
Kumar S; ICGEB-Emory Vaccine Center, International Center for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India.
Reddy ES; ICGEB-Emory Vaccine Center, International Center for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India; Kusuma School of Biological Sciences, Indian Institute of Technology, New Delhi, India.
Edara VV; Emory Vaccine Center, Emory University, Atlanta, GA 30322, USA; Department of Pediatrics, Emory University School of Medicine, Emory University, Atlanta, GA 30322, USA; Yerkes National Primate Research Center, Atlanta, GA 30329, USA.
Kauffman R; Emory Vaccine Center, Emory University, Atlanta, GA 30322, USA; Department of Pediatrics, Emory University School of Medicine, Emory University, Atlanta, GA 30322, USA.
Floyd K; Emory Vaccine Center, Emory University, Atlanta, GA 30322, USA; Department of Pediatrics, Emory University School of Medicine, Emory University, Atlanta, GA 30322, USA; Yerkes National Primate Research Center, Atlanta, GA 30329, USA.
Mantus G; Emory Vaccine Center, Emory University, Atlanta, GA 30322, USA; Department of Pediatrics, Emory University School of Medicine, Emory University, Atlanta, GA 30322, USA.
Savargaonkar D; ICMR-National Institute of Malaria Research, Dwarka, New Delhi, India.
Goel PK; Shaheed Hasan Khan Mewat Government Medical College, Nalhar, Mewat, Haryana, India.
Arora S; Department of Transfusion Medicine, Super Speciality Pediatric Hospital and Post Graduate Teaching Institute, Noida, UP, India.
Rahi M; Division of Epidemiology and Communicable Diseases, Indian Council of Medical Research, New Delhi, India.
Davis CW; Emory Vaccine Center, Emory University, Atlanta, GA 30322, USA; Deptartment of Microbiology and Immunology, Emory University School of Medicine, Emory University, Atlanta, GA 30322, USA.
Linderman S; Emory Vaccine Center, Emory University, Atlanta, GA 30322, USA; Department of Pediatrics, Emory University School of Medicine, Emory University, Atlanta, GA 30322, USA.
Wrammert J; Emory Vaccine Center, Emory University, Atlanta, GA 30322, USA; Department of Pediatrics, Emory University School of Medicine, Emory University, Atlanta, GA 30322, USA.
Suthar MS; Emory Vaccine Center, Emory University, Atlanta, GA 30322, USA; Department of Pediatrics, Emory University School of Medicine, Emory University, Atlanta, GA 30322, USA; Yerkes National Primate Research Center, Atlanta, GA 30329, USA.
Ahmed R; Emory Vaccine Center, Emory University, Atlanta, GA 30322, USA; Deptartment of Microbiology and Immunology, Emory University School of Medicine, Emory University, Atlanta, GA 30322, USA.
Sharma A; ICMR-National Institute of Malaria Research, Dwarka, New Delhi, India; Structural Parasitology Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India.
Murali-Krishna K; ICGEB-Emory Vaccine Center, International Center for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India; Emory Vaccine Center, Emory University, Atlanta, GA 30322, USA; Department of Pediatrics, Emory University School of Medicine, Emory University, Atlanta, GA 30322, USA. Electronic address: .
Chandele A; ICGEB-Emory Vaccine Center, International Center for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India. Electronic address: .
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Źródło :
Virology [Virology] 2021 Jun; Vol. 558, pp. 13-21. Date of Electronic Publication: 2021 Mar 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
B-Lymphocytes*/cytology
B-Lymphocytes*/immunology
Antibodies, Neutralizing/*analysis
Antibodies, Viral/*analysis
COVID-19/*immunology
Spike Glycoprotein, Coronavirus/*immunology
Adolescent ; Adult ; Aged ; COVID-19/epidemiology ; Humans ; Immunity, Humoral ; Immunoglobulin Isotypes/analysis ; India/epidemiology ; Male ; Middle Aged ; Pandemics ; Young Adult
Czasopismo naukowe
Tytuł :
Co-evolution of tumor and immune cells during progression of multiple myeloma.
Autorzy :
Liu R; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO, USA.
Gao Q; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO, USA.
Foltz SM; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO, USA.
Fowles JS; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.
Yao L; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO, USA.
Wang JT; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO, USA.
Cao S; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO, USA.
Sun H; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO, USA.
Wendl MC; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO, USA.; Department of Genetics, Washington University in St. Louis, St. Louis, MO, USA.; Department of Mathematics, Washington University in St. Louis, St. Louis, MO, USA.
Sethuraman S; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO, USA.
Weerasinghe A; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO, USA.
Rettig MP; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.
Storrs EP; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO, USA.
Yoon CJ; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO, USA.
Wyczalkowski MA; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO, USA.
McMichael JF; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO, USA.
Kohnen DR; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.
King J; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.
Goldsmith SR; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.
O'Neal J; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.
Fulton RS; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO, USA.
Fronick CC; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO, USA.
Ley TJ; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.
Jayasinghe RG; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO, USA.
Fiala MA; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.
Oh ST; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.; Center for Human Immunology and Immunotherapy Programs, Washington University in St. Louis, St. Louis, MO, USA.
DiPersio JF; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.; Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, USA.
Vij R; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA. .; Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, USA. .
Ding L; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA. .; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO, USA. .; Department of Genetics, Washington University in St. Louis, St. Louis, MO, USA. .; Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 May 07; Vol. 12 (1), pp. 2559. Date of Electronic Publication: 2021 May 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
B-Lymphocytes/*metabolism
Gene Expression Regulation, Neoplastic/*genetics
Multiple Myeloma/*genetics
Multiple Myeloma/*immunology
Neoplasm Recurrence, Local/*genetics
Tumor Microenvironment/*immunology
Aged ; B-Lymphocytes/cytology ; B-Lymphocytes/immunology ; Cell Lineage ; Clonal Evolution/genetics ; Cohort Studies ; Disease Progression ; Female ; Gene Expression Regulation, Neoplastic/immunology ; Haplotypes ; Humans ; Interleukin-1beta/blood ; Interleukin-6/blood ; Male ; Mass Spectrometry ; Middle Aged ; Multigene Family ; Multiple Myeloma/blood ; Multiple Myeloma/pathology ; Mutation ; Neoplasm Recurrence, Local/blood ; Neoplasm Recurrence, Local/immunology ; Proto-Oncogene Proteins c-fos/blood ; Proto-Oncogene Proteins c-jun/blood ; RNA-Seq ; Signal Transduction/genetics ; Signal Transduction/immunology ; Single-Cell Analysis
Czasopismo naukowe
Tytuł :
Nodal EBV-positive polymorphic B cell lymphoproliferative disorder with plasma cell differentiation: clinicopathological analysis of five cases.
Autorzy :
Satou A; Department of Surgical Pathology, Aichi Medical University Hospital, 1-1, Yazakokarimata, Nagakute, 480-1195, Japan. .
Tabata T; Department of Pathology, Okayama University Graduate School of Medicine, Okayama, Japan.
Suzuki Y; Department of Pathology and Laboratory Medicine, Nagoya University Hospital, Nagoya, Japan.
Sato Y; Division of Pathophysiology, Okayama University Graduate School of Health Sciences, Okayama, Japan.
Tahara I; Department of Pathology, Graduate School of Medicine, University of Yamanashi, Chuo, Japan.
Mochizuki K; Department of Pathology, Graduate School of Medicine, University of Yamanashi, Chuo, Japan.
Oishi N; Department of Pathology, Graduate School of Medicine, University of Yamanashi, Chuo, Japan.
Takahara T; Department of Surgical Pathology, Aichi Medical University Hospital, 1-1, Yazakokarimata, Nagakute, 480-1195, Japan.
Yoshino T; Department of Pathology, Okayama University Graduate School of Medicine, Okayama, Japan.
Tsuzuki T; Department of Surgical Pathology, Aichi Medical University Hospital, 1-1, Yazakokarimata, Nagakute, 480-1195, Japan.
Nakamura S; Department of Pathology and Laboratory Medicine, Nagoya University Hospital, Nagoya, Japan.
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Źródło :
Virchows Archiv : an international journal of pathology [Virchows Arch] 2021 May; Vol. 478 (5), pp. 969-976. Date of Electronic Publication: 2020 Nov 09.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Differentiation*
B-Lymphocytes/*pathology
Epstein-Barr Virus Infections/*pathology
Herpesvirus 4, Human/*pathogenicity
Lymphoma, Large B-Cell, Diffuse/*pathology
Lymphoproliferative Disorders/*pathology
Plasma Cells/*pathology
Aged ; Aged, 80 and over ; Antirheumatic Agents/adverse effects ; B-Lymphocytes/immunology ; B-Lymphocytes/virology ; Biomarkers, Tumor/analysis ; Biomarkers, Tumor/genetics ; Diagnosis, Differential ; Epstein-Barr Virus Infections/genetics ; Epstein-Barr Virus Infections/immunology ; Epstein-Barr Virus Infections/virology ; Female ; Genes, Immunoglobulin Heavy Chain ; Genes, T-Cell Receptor gamma ; Herpesvirus 4, Human/genetics ; Herpesvirus 4, Human/immunology ; Host-Pathogen Interactions ; Humans ; Lymphoma, Large B-Cell, Diffuse/genetics ; Lymphoma, Large B-Cell, Diffuse/immunology ; Lymphoma, Large B-Cell, Diffuse/virology ; Lymphoproliferative Disorders/genetics ; Lymphoproliferative Disorders/immunology ; Lymphoproliferative Disorders/virology ; Male ; Methotrexate/adverse effects ; Plasma Cells/immunology ; Plasma Cells/virology ; Predictive Value of Tests ; Risk Factors
Czasopismo naukowe
Tytuł :
Advances in Lupus Nephritis Pathogenesis: From Bench to Bedside.
Autorzy :
Obrișcă B; Department of Nephrology, Fundeni Clinical Institute, Fundeni Street 258, 022328 Bucharest, Romania.; Department of Nephrology, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Sorohan B; Department of Nephrology, Fundeni Clinical Institute, Fundeni Street 258, 022328 Bucharest, Romania.; Department of Nephrology, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Tuță L; Department of Nephrology, 'Ovidius' University, 900527 Constanta, Romania.
Ismail G; Department of Nephrology, Fundeni Clinical Institute, Fundeni Street 258, 022328 Bucharest, Romania.; Department of Nephrology, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Apr 05; Vol. 22 (7). Date of Electronic Publication: 2021 Apr 05.
Typ publikacji :
Journal Article; Review
MeSH Terms :
B-Lymphocytes*/immunology
B-Lymphocytes*/pathology
Kidney*/immunology
Kidney*/pathology
Lupus Nephritis*/drug therapy
Lupus Nephritis*/immunology
Lupus Nephritis*/pathology
Immunosuppressive Agents/*therapeutic use
Humans
Czasopismo naukowe
Tytuł :
Engineering antibody therapies for protective immunity.
Autorzy :
Lam N; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY.
Farber DL; Department of Surgery, Columbia University Irving Medical Center, New York, NY; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY. Electronic address: .
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Źródło :
The Journal of thoracic and cardiovascular surgery [J Thorac Cardiovasc Surg] 2021 Apr; Vol. 161 (4), pp. 1358-1361. Date of Electronic Publication: 2020 Jun 24.
Typ publikacji :
Editorial
MeSH Terms :
Antibodies*/genetics
Antibodies*/immunology
Antibodies*/metabolism
B-Lymphocytes*/immunology
B-Lymphocytes*/metabolism
Biological Therapy*
Cell Engineering*
Protein Engineering*
COVID-19/therapy ; Communicable Disease Control ; Communicable Diseases/immunology ; Humans ; Immunization, Passive
SCR Protocol :
COVID-19 serotherapy
Opinia redakcyjna
Tytuł :
A combination of the percentages of IFN-γ B cells is associated with acute hepatic rejection: a case control study.
Autorzy :
Zhu JQ; Department of Hepatobiliary and Pancreaticosplenic Surgery, Medical Research Center, Beijing Organ Transplant Center, Beijing Chaoyang Hospital, Capital Medical University, No. 8 Gongtinan Road, Chaoyang District, Beijing, 100020, China.
Wang J; Department of Hepatobiliary and Pancreaticosplenic Surgery, Medical Research Center, Beijing Organ Transplant Center, Beijing Chaoyang Hospital, Capital Medical University, No. 8 Gongtinan Road, Chaoyang District, Beijing, 100020, China.
Li XL; Department of Hepatobiliary and Pancreaticosplenic Surgery, Medical Research Center, Beijing Organ Transplant Center, Beijing Chaoyang Hospital, Capital Medical University, No. 8 Gongtinan Road, Chaoyang District, Beijing, 100020, China.
Xu WL; Department of Hepatobiliary and Pancreaticosplenic Surgery, Medical Research Center, Beijing Organ Transplant Center, Beijing Chaoyang Hospital, Capital Medical University, No. 8 Gongtinan Road, Chaoyang District, Beijing, 100020, China.
Lv SC; Department of Hepatobiliary and Pancreaticosplenic Surgery, Medical Research Center, Beijing Organ Transplant Center, Beijing Chaoyang Hospital, Capital Medical University, No. 8 Gongtinan Road, Chaoyang District, Beijing, 100020, China.
Zhao X; Department of Hepatobiliary and Pancreaticosplenic Surgery, Medical Research Center, Beijing Organ Transplant Center, Beijing Chaoyang Hospital, Capital Medical University, No. 8 Gongtinan Road, Chaoyang District, Beijing, 100020, China.
Lang R; Department of Hepatobiliary and Pancreaticosplenic Surgery, Medical Research Center, Beijing Organ Transplant Center, Beijing Chaoyang Hospital, Capital Medical University, No. 8 Gongtinan Road, Chaoyang District, Beijing, 100020, China. .
He Q; Department of Hepatobiliary and Pancreaticosplenic Surgery, Medical Research Center, Beijing Organ Transplant Center, Beijing Chaoyang Hospital, Capital Medical University, No. 8 Gongtinan Road, Chaoyang District, Beijing, 100020, China. .
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Źródło :
Journal of translational medicine [J Transl Med] 2021 May 01; Vol. 19 (1), pp. 187. Date of Electronic Publication: 2021 May 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
B-Lymphocytes*
Graft Rejection*
Case-Control Studies ; Granzymes ; Liver
Czasopismo naukowe
Tytuł :
Protective effect of trichostatin A on CD19 regulatory B cells in heart transplantation.
Autorzy :
Zhou B; Department of Cardiothoracic Surgery, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang 310014, P.R. China.
Mei F; Department of Cardiothoracic Surgery, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang 310014, P.R. China.
Wu C; Department of Cardiothoracic Surgery, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang 310014, P.R. China.
Xu H; Department of Cardiothoracic Surgery, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang 310014, P.R. China.
Liu Z; Department of Cardiothoracic Surgery, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang 310014, P.R. China.
Cui Y; Department of Cardiothoracic Surgery, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang 310014, P.R. China.
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Źródło :
Molecular medicine reports [Mol Med Rep] 2021 May; Vol. 23 (5). Date of Electronic Publication: 2021 Mar 24.
Typ publikacji :
Journal Article
MeSH Terms :
Heart Transplantation*
B-Lymphocytes, Regulatory/*immunology
Hydroxamic Acids/*pharmacology
Immune Tolerance/*immunology
Animals ; Antigens, CD19/immunology ; Antigens, CD1d/immunology ; B-Lymphocytes, Regulatory/drug effects ; CD5 Antigens/immunology ; Cell Count ; Cell Lineage/drug effects ; Cell Lineage/immunology ; Disease Models, Animal ; Flow Cytometry ; Histone Deacetylase Inhibitors/pharmacology ; Humans ; Immune Tolerance/drug effects ; Mice ; Protective Agents/pharmacology
Czasopismo naukowe
Tytuł :
Circulating Adaptive Immune Cells Expressing the Gut Homing Marker α4β7 Integrin Are Decreased in COVID-19.
Autorzy :
Müller TM; Department of Medicine 1 and Deutsches Zentrum Immuntherapie (DZI), University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Becker E; Department of Medicine 1 and Deutsches Zentrum Immuntherapie (DZI), University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Wiendl M; Department of Medicine 1 and Deutsches Zentrum Immuntherapie (DZI), University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Schulze LL; Department of Medicine 1 and Deutsches Zentrum Immuntherapie (DZI), University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Voskens C; Department of Dermatology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Völkl S; Department of Internal Medicine 5, Hematology and Clinical Oncology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Kremer AE; Department of Medicine 1 and Deutsches Zentrum Immuntherapie (DZI), University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Neurath MF; Department of Medicine 1 and Deutsches Zentrum Immuntherapie (DZI), University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Zundler S; Department of Medicine 1 and Deutsches Zentrum Immuntherapie (DZI), University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
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Źródło :
Frontiers in immunology [Front Immunol] 2021 Apr 20; Vol. 12, pp. 639329. Date of Electronic Publication: 2021 Apr 20 (Print Publication: 2021).
Typ publikacji :
Journal Article
MeSH Terms :
B-Lymphocytes/*metabolism
COVID-19/*immunology
Integrin alpha4/*metabolism
Integrins/*metabolism
SARS-CoV-2/*immunology
T-Lymphocytes/*metabolism
Adult ; B-Lymphocytes/immunology ; Biomarkers/analysis ; COVID-19/pathology ; Female ; Humans ; Immunologic Memory/immunology ; Intestinal Mucosa/cytology ; Intestinal Mucosa/immunology ; Lymphocyte Count ; Male ; Middle Aged ; T-Lymphocytes/immunology
Czasopismo naukowe
Tytuł :
Case Report: Complete and Fast Recovery From Severe COVID-19 in a Pemphigus Patient Treated With Rituximab.
Autorzy :
Sinagra JL; Molecular and Cell Biology Laboratory IDI-IRCCS, Rome, Italy.
Vedovelli C; Department of Infectious Diseases, Central Hospital of Bolzano, Bolzano, Italy.
Binazzi R; Department of Infectious Diseases, Central Hospital of Bolzano, Bolzano, Italy.
Salemme A; Molecular and Cell Biology Laboratory IDI-IRCCS, Rome, Italy.
Moro F; Molecular and Cell Biology Laboratory IDI-IRCCS, Rome, Italy.
Mazzanti C; Rare Diseases Unit, IDI-IRCCS, Rome, Italy.
Didona B; Rare Diseases Unit, IDI-IRCCS, Rome, Italy.
Di Zenzo G; Molecular and Cell Biology Laboratory IDI-IRCCS, Rome, Italy.
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Źródło :
Frontiers in immunology [Front Immunol] 2021 Apr 16; Vol. 12, pp. 665522. Date of Electronic Publication: 2021 Apr 16 (Print Publication: 2021).
Typ publikacji :
Case Reports; Research Support, Non-U.S. Gov't
MeSH Terms :
Adrenal Cortex Hormones/*therapeutic use
B-Lymphocytes/*immunology
COVID-19/*drug therapy
Pemphigus/*immunology
Rituximab/*adverse effects
Adrenal Cortex Hormones/adverse effects ; B-Lymphocytes/metabolism ; COVID-19/complications ; COVID-19/physiopathology ; Female ; Fever ; Humans ; Immunoglobulin G/immunology ; Inflammation/drug therapy ; Middle Aged ; Oxygen Inhalation Therapy ; Pemphigus/complications ; Pemphigus/drug therapy ; Rituximab/therapeutic use
Raport
Tytuł :
Extremely potent human monoclonal antibodies from COVID-19 convalescent patients.
Autorzy :
Andreano E; Monoclonal Antibody Discovery (MAD) Lab, Fondazione Toscana Life Sciences, Siena, Italy.
Nicastri E; National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, Rome, Italy.
Paciello I; Monoclonal Antibody Discovery (MAD) Lab, Fondazione Toscana Life Sciences, Siena, Italy.
Pileri P; Monoclonal Antibody Discovery (MAD) Lab, Fondazione Toscana Life Sciences, Siena, Italy.
Manganaro N; Monoclonal Antibody Discovery (MAD) Lab, Fondazione Toscana Life Sciences, Siena, Italy.
Piccini G; VisMederi S.r.l, Siena, Italy.
Manenti A; VisMederi S.r.l, Siena, Italy; VisMederi Research S.r.l., Siena, Italy.
Pantano E; Monoclonal Antibody Discovery (MAD) Lab, Fondazione Toscana Life Sciences, Siena, Italy.
Kabanova A; Monoclonal Antibody Discovery (MAD) Lab, Fondazione Toscana Life Sciences, Siena, Italy; Tumour Immunology Unit, Fondazione Toscana Life Sciences, Siena, Italy.
Troisi M; Monoclonal Antibody Discovery (MAD) Lab, Fondazione Toscana Life Sciences, Siena, Italy; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Siena, Italy.
Vacca F; Monoclonal Antibody Discovery (MAD) Lab, Fondazione Toscana Life Sciences, Siena, Italy; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Siena, Italy.
Cardamone D; Monoclonal Antibody Discovery (MAD) Lab, Fondazione Toscana Life Sciences, Siena, Italy; University of Turin, Turin, Italy.
De Santi C; Monoclonal Antibody Discovery (MAD) Lab, Fondazione Toscana Life Sciences, Siena, Italy.
Torres JL; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Ozorowski G; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Benincasa L; VisMederi Research S.r.l., Siena, Italy.
Jang H; Center for Vaccines and Immunology, University of Georgia, Athens, GA 30602, USA.
Di Genova C; Viral Pseudotype Unit, Medway School of Pharmacy, University of Kent, Chatham, UK.
Depau L; MedBiotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, Siena, Italy.
Brunetti J; MedBiotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, Siena, Italy.
Agrati C; National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, Rome, Italy.
Capobianchi MR; National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, Rome, Italy.
Castilletti C; National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, Rome, Italy.
Emiliozzi A; Department of Medical Biotechnologies, University of Siena, Siena, Italy; Department of Medical Sciences, Infectious and Tropical Diseases Unit, University Hospital of Siena, Siena, Italy.
Fabbiani M; Department of Medical Sciences, Infectious and Tropical Diseases Unit, University Hospital of Siena, Siena, Italy.
Montagnani F; Department of Medical Biotechnologies, University of Siena, Siena, Italy; Department of Medical Sciences, Infectious and Tropical Diseases Unit, University Hospital of Siena, Siena, Italy.
Bracci L; MedBiotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, Siena, Italy.
Sautto G; Center for Vaccines and Immunology, University of Georgia, Athens, GA 30602, USA.
Ross TM; Center for Vaccines and Immunology, University of Georgia, Athens, GA 30602, USA; Department of Infectious Diseases, University of Georgia, Athens, GA 30602, USA.
Montomoli E; VisMederi S.r.l, Siena, Italy; VisMederi Research S.r.l., Siena, Italy; Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy.
Temperton N; Viral Pseudotype Unit, Medway School of Pharmacy, University of Kent, Chatham, UK.
Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Sala C; Monoclonal Antibody Discovery (MAD) Lab, Fondazione Toscana Life Sciences, Siena, Italy.
Ippolito G; National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, Rome, Italy.
Rappuoli R; Monoclonal Antibody Discovery (MAD) Lab, Fondazione Toscana Life Sciences, Siena, Italy; Faculty of Medicine, Imperial College, London, UK. Electronic address: .
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Źródło :
Cell [Cell] 2021 Apr 01; Vol. 184 (7), pp. 1821-1835.e16. Date of Electronic Publication: 2021 Feb 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
COVID-19*/immunology
COVID-19*/prevention & control
COVID-19*/therapy
Convalescence*
Antibodies, Monoclonal/*administration & dosage
Antibodies, Neutralizing/*administration & dosage
Antibodies, Viral/*administration & dosage
B-Lymphocytes/*immunology
3T3 Cells ; Animals ; Antibodies, Monoclonal/isolation & purification ; Antibodies, Neutralizing/isolation & purification ; Antibodies, Viral/isolation & purification ; B-Lymphocytes/cytology ; Chlorocebus aethiops ; Disease Models, Animal ; Female ; HEK293 Cells ; Humans ; Immunoglobulin Fc Fragments/immunology ; Male ; Mice ; Spike Glycoprotein, Coronavirus/immunology ; Vero Cells
Czasopismo naukowe
Tytuł :
Anti-interleukin-21 antibody and liraglutide for the preservation of β-cell function in adults with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled, phase 2 trial.
Autorzy :
von Herrath M; Novo Nordisk A/S, Søborg, Denmark.
Bain SC; Swansea University Medical School, Swansea, UK.
Bode B; Atlanta Diabetes Associates, Atlanta, GA, USA; Emory University School of Medicine, Atlanta, GA, USA.
Clausen JO; Novo Nordisk A/S, Søborg, Denmark.
Coppieters K; Novo Nordisk A/S, Måløv, Denmark.
Gaysina L; Kazan Federal University, Kazan, Russia.
Gumprecht J; Medical University of Silesia, Katowice, Poland.
Hansen TK; Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark.
Mathieu C; Clinical and Experimental Endocrinology, UZ Gasthuisberg, University of Leuven, Leuven, Belgium.
Morales C; Endocrinology and Nutrition Department, Virgen Macarena Hospital, Seville, Spain.
Mosenzon O; Diabetes Unit, Department of Endocrinology and Metabolism, Hadassah Medical Centre, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Segel S; Novo Nordisk A/S, Aalborg, Denmark.
Tsoukas G; Department of Medicine, McGill University, Montreal, QC, Canada.
Pieber TR; Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Graz, Austria. Electronic address: .
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Corporate Authors :
Anti-IL-21–liraglutide Study Group investigators and contributors
Źródło :
The lancet. Diabetes & endocrinology [Lancet Diabetes Endocrinol] 2021 Apr; Vol. 9 (4), pp. 212-224. Date of Electronic Publication: 2021 Mar 01.
Typ publikacji :
Clinical Trial, Phase II; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Monoclonal/*administration & dosage
B-Lymphocytes/*physiology
Diabetes Mellitus, Type 1/*drug therapy
Hypoglycemic Agents/*administration & dosage
Interleukins/*antagonists & inhibitors
Liraglutide/*administration & dosage
Adult ; B-Lymphocytes/drug effects ; Diabetes Mellitus, Type 1/blood ; Diabetes Mellitus, Type 1/diagnosis ; Double-Blind Method ; Drug Therapy, Combination ; Female ; Follow-Up Studies ; Humans ; Interleukins/blood ; Male ; Young Adult
Czasopismo naukowe
Tytuł :
il-10 Gene Locus DNA Methylation in Regulatory B Cells.
Autorzy :
Tonon S; Department of Medicine, University of Udine, Udine, Italy. .
Martinis E; Department of Medicine, University of Udine, Udine, Italy.
Pucillo CEM; Department of Medicine, University of Udine, Udine, Italy.
Mion F; Department of Medicine, University of Udine, Udine, Italy.
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2270, pp. 323-339.
Typ publikacji :
Journal Article; Review
MeSH Terms :
DNA Methylation*
B-Lymphocytes/*physiology
B-Lymphocytes, Regulatory/*metabolism
Interleukin-10/*genetics
Animals ; B-Lymphocytes/immunology ; B-Lymphocytes/metabolism ; B-Lymphocytes, Regulatory/immunology ; Cell Differentiation/genetics ; CpG Islands ; Cytokines/genetics ; Epigenesis, Genetic ; Epigenomics/methods ; Humans ; Interleukin-10/immunology ; Polymerase Chain Reaction/methods
Czasopismo naukowe
Tytuł :
The imbalance between regulatory and memory B cells accompanied by an increased number of circulating T-follicular helper cells in MOG-antibody-associated demyelination.
Autorzy :
Li X; Department of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Wulumuqi Zhong Road, Shanghai 200040, China; Department of Neurology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Wang L; Department of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Wulumuqi Zhong Road, Shanghai 200040, China.
Zhou L; Department of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Wulumuqi Zhong Road, Shanghai 200040, China.
ZhangBao J; Department of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Wulumuqi Zhong Road, Shanghai 200040, China.
Miao MZ; Department of Oral and Craniofacial Health Sciences, Adams School of Dentistry, University of North Carolina at Chapel Hill, NC, United States; Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Lu C; Department of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Wulumuqi Zhong Road, Shanghai 200040, China.
Lu J; Department of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Wulumuqi Zhong Road, Shanghai 200040, China.
Quan C; Department of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Wulumuqi Zhong Road, Shanghai 200040, China. Electronic address: .
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Źródło :
Multiple sclerosis and related disorders [Mult Scler Relat Disord] 2019 Nov; Vol. 36, pp. 101397. Date of Electronic Publication: 2019 Sep 16.
Typ publikacji :
Journal Article
MeSH Terms :
B-Lymphocytes*/immunology
T-Lymphocytes, Helper-Inducer*/immunology
Aquaporin 4/*immunology
Autoantibodies/*blood
Myelin-Oligodendrocyte Glycoprotein/*immunology
Neuromyelitis Optica/*immunology
Adolescent ; Adult ; Aged ; B-Lymphocytes, Regulatory/immunology ; Child ; Child, Preschool ; Female ; Humans ; Male ; Middle Aged ; Neuromyelitis Optica/blood ; Young Adult
Czasopismo naukowe
Tytuł :
A Green and Blue Monochromatic Light Combination Therapy Reduces Oxidative Stress and Enhances B-Lymphocyte Proliferation through Promoting Melatonin Secretion.
Autorzy :
Zhang Y; Laboratory of Anatomy of Domestic Animals, College of Veterinary Medicine, China Agricultural University, Haidian, Beijing 100193, China.
Wang Z; Laboratory of Anatomy of Domestic Animals, College of Veterinary Medicine, China Agricultural University, Haidian, Beijing 100193, China.
Cao J; Laboratory of Anatomy of Domestic Animals, College of Veterinary Medicine, China Agricultural University, Haidian, Beijing 100193, China.
Dong Y; Laboratory of Anatomy of Domestic Animals, College of Veterinary Medicine, China Agricultural University, Haidian, Beijing 100193, China.
Chen Y; Laboratory of Anatomy of Domestic Animals, College of Veterinary Medicine, China Agricultural University, Haidian, Beijing 100193, China.
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Źródło :
Oxidative medicine and cellular longevity [Oxid Med Cell Longev] 2021 Mar 19; Vol. 2021, pp. 5595376. Date of Electronic Publication: 2021 Mar 19 (Print Publication: 2021).
Typ publikacji :
Journal Article
MeSH Terms :
Cell Proliferation*
Light*
Oxidative Stress*
B-Lymphocytes/*radiation effects
Melatonin/*metabolism
Phototherapy/*methods
Animals ; Avian Proteins/metabolism ; B-Lymphocytes/metabolism ; B-Lymphocytes/physiology ; Chickens ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Male ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Receptors, Melatonin/metabolism
Czasopismo naukowe
Tytuł :
High levels of gut-homing immunoglobulin A+ B lymphocytes support the pathogenic role of intestinal mucosal hyperresponsiveness in immunoglobulin A nephropathy patients.
Autorzy :
Sallustio F; Department of Interdisciplinary Medicine, University of Bari 'Aldo Moro', Bari, Italy.
Curci C; Department of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari 'Aldo Moro', Bari, Italy.; Nephrology, Dialysis and Transplantation Unit, Department of Emergency and Organ Transplantation, University 'Aldo Moro', Bari, Italy.
Chaoul N; Allergology Unit, Department of Emergency and Organ Transplantation, University 'Aldo Moro', Bari, Italy.
Fontò G; Nephrology, Dialysis and Transplantation Unit, Department of Emergency and Organ Transplantation, University 'Aldo Moro', Bari, Italy.
Lauriero G; Nephrology, Dialysis and Transplantation Unit, Department of Emergency and Organ Transplantation, University 'Aldo Moro', Bari, Italy.
Picerno A; Nephrology, Dialysis and Transplantation Unit, Department of Emergency and Organ Transplantation, University 'Aldo Moro', Bari, Italy.
Divella C; Nephrology, Dialysis and Transplantation Unit, Department of Emergency and Organ Transplantation, University 'Aldo Moro', Bari, Italy.
Di Leo V; Nephrology, Dialysis and Transplantation Unit, Department of Emergency and Organ Transplantation, University 'Aldo Moro', Bari, Italy.
De Angelis M; Department of Soil, Plant and Food Sciences, University of Bari Aldo Moro, Bari, Italy.
Ben Mkaddem S; Faculty of Medicine, Center for Research on Inflammation, Paris Diderot University, INSERM U1149, ELR8252 CNRS, Paris, France.
Macchia L; Allergology Unit, Department of Emergency and Organ Transplantation, University 'Aldo Moro', Bari, Italy.
Gallone A; Department of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari 'Aldo Moro', Bari, Italy.
Monteiro RC; Faculty of Medicine, Center for Research on Inflammation, Paris Diderot University, INSERM U1149, ELR8252 CNRS, Paris, France.
Pesce F; Nephrology, Dialysis and Transplantation Unit, Department of Emergency and Organ Transplantation, University 'Aldo Moro', Bari, Italy.
Gesualdo L; Nephrology, Dialysis and Transplantation Unit, Department of Emergency and Organ Transplantation, University 'Aldo Moro', Bari, Italy.
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Źródło :
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association [Nephrol Dial Transplant] 2021 Feb 20; Vol. 36 (3), pp. 452-464.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
B-Lymphocytes/*immunology
Gastrointestinal Microbiome/*immunology
Glomerulonephritis, IGA/*complications
Immunity, Mucosal/*immunology
Immunoglobulin A/*blood
Inflammation/*pathology
Intestinal Mucosa/*immunology
Adult ; B-Lymphocytes/metabolism ; B-Lymphocytes/pathology ; Case-Control Studies ; Cytokines/metabolism ; Female ; Humans ; Inflammation/etiology ; Inflammation/metabolism ; Intestinal Mucosa/metabolism ; Intestinal Mucosa/pathology ; Male ; Middle Aged
Czasopismo naukowe
Tytuł :
HIV-1 Tat Activates Akt/mTORC1 Pathway and AICDA Expression by Downregulating Its Transcriptional Inhibitors in B Cells.
Autorzy :
Akbay B; CNRS UMR9018, Institut Gustave Roussy, Université Paris-Saclay, 94805 Villejuif, France.; Department of Molecular Biology and Genetics, Faculty of Biology and Biotechnology, al-Farabi Kazakh National University, Almaty 050040, Kazakhstan.
Germini D; CNRS UMR9018, Institut Gustave Roussy, Université Paris-Saclay, 94805 Villejuif, France.
Bissenbaev AK; Department of Molecular Biology and Genetics, Faculty of Biology and Biotechnology, al-Farabi Kazakh National University, Almaty 050040, Kazakhstan.; Scientific Research Institute of Biology and Biotechnology Problems, al-Farabi Kazakh National University, Almaty 050040, Kazakhstan.
Musinova YR; Koltzov Institute of Developmental Biology of Russian Academy of Sciences, 119991 Moscow, Russia.; Belozersky Institute of Physicochemical Biology, Moscow State University, 119899 Moscow, Russia.
Sheval EV; Belozersky Institute of Physicochemical Biology, Moscow State University, 119899 Moscow, Russia.
Vassetzky Y; CNRS UMR9018, Institut Gustave Roussy, Université Paris-Saclay, 94805 Villejuif, France.; Koltzov Institute of Developmental Biology of Russian Academy of Sciences, 119991 Moscow, Russia.
Dokudovskaya S; CNRS UMR9018, Institut Gustave Roussy, Université Paris-Saclay, 94805 Villejuif, France.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Feb 04; Vol. 22 (4). Date of Electronic Publication: 2021 Feb 04.
Typ publikacji :
Journal Article
MeSH Terms :
DNA Damage*
Gene Expression Regulation*
B-Lymphocytes/*pathology
Cytidine Deaminase/*metabolism
Mechanistic Target of Rapamycin Complex 1/*metabolism
Proto-Oncogene Proteins c-akt/*metabolism
tat Gene Products, Human Immunodeficiency Virus/*metabolism
B-Lymphocytes/immunology ; B-Lymphocytes/metabolism ; Cells, Cultured ; Cytidine Deaminase/genetics ; Humans ; Mechanistic Target of Rapamycin Complex 1/genetics ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-myb/genetics ; Proto-Oncogene Proteins c-myb/metabolism ; Reactive Oxygen Species/metabolism ; Repressor Proteins/genetics ; Repressor Proteins/metabolism ; Transcriptional Activation ; tat Gene Products, Human Immunodeficiency Virus/genetics
Czasopismo naukowe
Tytuł :
Smc3 dosage regulates B cell transit through germinal centers and restricts their malignant transformation.
Autorzy :
Rivas MA; Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Meydan C; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Al-Saud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.
Chin CR; Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Al-Saud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.
Challman MF; Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Kim D; Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Bhinder B; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, USA.
Kloetgen A; Department of Pathology, New York University School of Medicine, New York, NY, USA.
Viny AD; Human Oncology & Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Teater MR; Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
McNally DR; Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, USA.
Doane AS; Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, USA.
Béguelin W; Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Fernández MTC; Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Shen H; Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Wang X; Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Levine RL; Human Oncology & Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Chen Z; Division of Biostatistics and Epidemiology, Department of Population Health Sciences, Weill Cornell Medicine, New York, NY, USA.
Tsirigos A; Department of Pathology, New York University School of Medicine, New York, NY, USA.; Institute for Computational Medicine, New York University School of Medicine, New York, NY, USA.; Applied Bioinformatics Laboratories, New York University School of Medicine, New York, NY, USA.
Elemento O; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Al-Saud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, USA.
Mason CE; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Al-Saud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.; The WorldQuant Initiative for Quantitative Prediction, Weill Cornell Medicine, New York, NY, USA.; The Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.
Melnick AM; Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA. .
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Źródło :
Nature immunology [Nat Immunol] 2021 Feb; Vol. 22 (2), pp. 240-253. Date of Electronic Publication: 2021 Jan 11.
Typ publikacji :
Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Dosage*
Immunity, Humoral*
B-Lymphocytes/*metabolism
Cell Cycle Proteins/*deficiency
Cell Cycle Proteins/*genetics
Cell Transformation, Neoplastic/*genetics
Chondroitin Sulfate Proteoglycans/*genetics
Chromosomal Proteins, Non-Histone/*deficiency
Chromosomal Proteins, Non-Histone/*genetics
Germinal Center/*metabolism
Lymphoma, B-Cell/*genetics
Animals ; B-Lymphocytes/immunology ; B-Lymphocytes/pathology ; Cell Cycle Proteins/metabolism ; Cell Differentiation ; Cell Proliferation ; Cell Transformation, Neoplastic/immunology ; Cell Transformation, Neoplastic/metabolism ; Cell Transformation, Neoplastic/pathology ; Cells, Cultured ; Chondroitin Sulfate Proteoglycans/deficiency ; Chondroitin Sulfate Proteoglycans/metabolism ; Chromosomal Proteins, Non-Histone/metabolism ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Gene Deletion ; Gene Expression Regulation, Neoplastic ; Germinal Center/immunology ; Germinal Center/pathology ; Haploinsufficiency ; Histone-Lysine N-Methyltransferase/genetics ; Histone-Lysine N-Methyltransferase/metabolism ; Humans ; Lymphoma, B-Cell/immunology ; Lymphoma, B-Cell/metabolism ; Lymphoma, B-Cell/pathology ; Lymphoma, Large B-Cell, Diffuse/genetics ; Lymphoma, Large B-Cell, Diffuse/immunology ; Lymphoma, Large B-Cell, Diffuse/metabolism ; Lymphoma, Large B-Cell, Diffuse/pathology ; Mice, Inbred C57BL ; Mice, Knockout ; Myeloid-Lymphoid Leukemia Protein/genetics ; Myeloid-Lymphoid Leukemia Protein/metabolism ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
Autoantibodies in outbred Swiss Webster mice following exposure to gold and mercury.
Autorzy :
Amirhosseini M; Division of Inflammation and Infection, Department of Biomedical and Clinical Sciences, Faculty of Medicine and Health Sciences, Linköping University, Linköping, Sweden.
Alkaissi H; Division of Inflammation and Infection, Department of Biomedical and Clinical Sciences, Faculty of Medicine and Health Sciences, Linköping University, Linköping, Sweden.
Hultman PA; Division of Inflammation and Infection, Department of Biomedical and Clinical Sciences, Faculty of Medicine and Health Sciences, Linköping University, Linköping, Sweden; Department of Clinical Pathology, Linköping University, Linköping, Sweden.
Havarinasab S; Division of Clinical Chemistry, Department of Biomedical and Clinical Sciences, Faculty of Medicine and Health Sciences, Linköping University, Linköping, Sweden. Electronic address: .
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Źródło :
Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2021 Feb 01; Vol. 412, pp. 115379. Date of Electronic Publication: 2020 Dec 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Antinuclear/*blood
Autoimmunity/*drug effects
B-Lymphocytes/*drug effects
Gold Sodium Thiomalate/*toxicity
Immunoglobulin G/*blood
Lymphocyte Activation/*drug effects
Mercuric Chloride/*toxicity
Administration, Oral ; Animals ; Antigen-Antibody Complex ; B-Lymphocytes/immunology ; B-Lymphocytes/metabolism ; Chromatin/immunology ; Chromosomal Proteins, Non-Histone/immunology ; Exoribonucleases/immunology ; Exosome Multienzyme Ribonuclease Complex/immunology ; Female ; Gold Sodium Thiomalate/administration & dosage ; Histones/immunology ; Injections, Intramuscular ; Kidney/drug effects ; Kidney/immunology ; Mercuric Chloride/administration & dosage ; Mice ; Spleen/drug effects ; Spleen/immunology
Czasopismo naukowe
Tytuł :
The regulation of DOCK family proteins on T and B cells.
Autorzy :
Chen Y; Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Chen Y; The Second Department of Pediatrics, Affiliated Hospital of Zunyi, Zunyi, Guizhou, China.
Yin W; Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Han H; Department of Hematology of Liyuan Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Miller H; The Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA.
Li J; Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Herrada AA; Lymphatic and Inflammation Research Laboratory, Facultad de Ciencias de la Salud, Instituto de Ciencias Biomedicas, Universidad Autonoma de Chile, Talca, Chile.
Kubo M; Laboratory for Cytokine Regulation, Center for Integrative Medical Science (IMS), RIKEN Yokohama Institute, Yokohama, Kanagawa, Japan.
Sui Z; Division of Medical and Biological Measurement, National Institute of Metrology, Beijing, China.
Gong Q; Department of immunology, School of Medicine, Yangtze University, Jingzhou, China.; Clinical Molecular Immunology Center, School of Medicine, Yangtze University, Jingzhou, China.
Liu C; Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
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Źródło :
Journal of leukocyte biology [J Leukoc Biol] 2021 Feb; Vol. 109 (2), pp. 383-394. Date of Electronic Publication: 2020 Jun 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
B-Lymphocytes/*metabolism
Guanine Nucleotide Exchange Factors/*metabolism
T-Lymphocytes/*metabolism
Animals ; B-Lymphocytes/cytology ; B-Lymphocytes/immunology ; Guanine Nucleotide Exchange Factors/chemistry ; Humans ; Immune Tolerance ; Lymphocyte Activation/immunology ; Protein Domains ; T-Lymphocytes/cytology ; T-Lymphocytes/immunology
Czasopismo naukowe
Tytuł :
Yishen-tongbi decoction inhibits excessive activation of B cells by activating the FcγRIIb/Lyn/SHP-1 pathway and attenuates the inflammatory response in CIA rats.
Autorzy :
Hu C; First Clinical Medical School, Guangzhou University of Chinese Medicine, Guangzhou, China; Lingnan Medical Research Center of Guangzhou University of Chinese Medicine, Guangzhou, China.
Peng S; First Clinical Medical School, Guangzhou University of Chinese Medicine, Guangzhou, China; Lingnan Medical Research Center of Guangzhou University of Chinese Medicine, Guangzhou, China.
Zhao L; First Clinical Medical School, Guangzhou University of Chinese Medicine, Guangzhou, China.
Li M; First Clinical Medical School, Guangzhou University of Chinese Medicine, Guangzhou, China.
Liu M; First Clinical Medical School, Guangzhou University of Chinese Medicine, Guangzhou, China.
Xu Y; First Clinical Medical School, Guangzhou University of Chinese Medicine, Guangzhou, China.
Chen G; Department of Rheumatology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China; Baiyun Hospital of The First Affiliated Hospital of Guangzhou University of Chinese Medicine, China. Electronic address: .
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Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2021 Feb; Vol. 134, pp. 111166. Date of Electronic Publication: 2020 Dec 26.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Inflammatory Agents/*pharmacology
Arthritis, Experimental/*prevention & control
B-Lymphocytes/*drug effects
Drugs, Chinese Herbal/*pharmacology
Joints/*drug effects
Lymphocyte Activation/*drug effects
Protein Tyrosine Phosphatase, Non-Receptor Type 6/*metabolism
Receptors, IgG/*metabolism
src-Family Kinases/*metabolism
Animals ; Apoptosis/drug effects ; Arthritis, Experimental/chemically induced ; Arthritis, Experimental/immunology ; Arthritis, Experimental/metabolism ; B-Lymphocytes/immunology ; B-Lymphocytes/metabolism ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Collagen Type II ; Female ; Humans ; Joints/immunology ; Joints/metabolism ; Joints/pathology ; Protein Tyrosine Phosphatase, Non-Receptor Type 6/genetics ; Rats, Wistar ; Receptors, IgG/genetics ; Signal Transduction ; src-Family Kinases/genetics
Czasopismo naukowe
Tytuł :
Loop extrusion mediates physiological Igh locus contraction for RAG scanning.
Autorzy :
Dai HQ; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA. .; Department of Genetics, Harvard Medical School, Boston, MA, USA. .
Hu H; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.
Lou J; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.
Ye AY; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.
Ba Z; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.
Zhang X; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.
Zhang Y; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.
Zhao L; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.
Yoon HS; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.
Chapdelaine-Williams AM; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.
Kyritsis N; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.
Chen H; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.
Johnson K; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.
Lin S; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.
Conte A; Lymphocyte Nuclear Biology, NIAMS, NIH, Bethesda, MD, USA.; Center of Cancer Research, NCI, NIH, Bethesda, MD, USA.
Casellas R; Lymphocyte Nuclear Biology, NIAMS, NIH, Bethesda, MD, USA.; Center of Cancer Research, NCI, NIH, Bethesda, MD, USA.
Lee CS; Department of Life Science, National Tsing Hua University, Institute of Molecular and Cellular Biology, Hsinchu, Taiwan, R.O.C.. .
Alt FW; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA. .; Department of Genetics, Harvard Medical School, Boston, MA, USA. .
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Źródło :
Nature [Nature] 2021 Feb; Vol. 590 (7845), pp. 338-343. Date of Electronic Publication: 2021 Jan 13.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Nucleic Acid Conformation*
B-Lymphocytes/*metabolism
DNA-Binding Proteins/*metabolism
Endonucleases/*metabolism
Homeodomain Proteins/*metabolism
Immunoglobulin Heavy Chains/*genetics
Animals ; B-Lymphocytes/cytology ; B-Lymphocytes/enzymology ; Cell Line ; Cells, Cultured ; DNA-Binding Proteins/deficiency ; DNA-Binding Proteins/genetics ; Down-Regulation ; Endonucleases/deficiency ; Endonucleases/genetics ; G1 Phase Cell Cycle Checkpoints ; High-Throughput Nucleotide Sequencing ; Homeodomain Proteins/genetics ; Mice ; Mice, Inbred C57BL ; Proteins/genetics ; Proteins/metabolism ; V(D)J Recombination/genetics
Czasopismo naukowe
Tytuł :
Epstein-Barr Virus-Encoded Latent Membrane Protein 1 and B-Cell Growth Transformation Induce Lipogenesis through Fatty Acid Synthase.
Autorzy :
Hulse M; Fels Institute for Cancer Research and Molecular Biology, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.
Johnson SM; Fels Institute for Cancer Research and Molecular Biology, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.
Boyle S; The Wistar Institute, Philadelphia, Pennsylvania, USA.
Caruso LB; The Wistar Institute, Philadelphia, Pennsylvania, USA.
Tempera I; The Wistar Institute, Philadelphia, Pennsylvania, USA .
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Źródło :
Journal of virology [J Virol] 2021 Jan 28; Vol. 95 (4). Date of Electronic Publication: 2021 Jan 28 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
B-Lymphocytes*/pathology
B-Lymphocytes*/virology
Cell Transformation, Neoplastic*
Lipogenesis*
Epstein-Barr Virus Infections/*virology
Fatty Acid Synthase, Type I/*metabolism
Viral Matrix Proteins/*metabolism
Cell Line, Tumor ; Cellular Reprogramming ; Herpesvirus 4, Human/physiology ; Humans
Czasopismo naukowe
Tytuł :
Large remodeling of the Myc-induced cell surface proteome in B cells and prostate cells creates new opportunities for immunotherapy.
Autorzy :
Chen W; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158.; Department of Therapeutic Discovery, Amgen Research, Thousand Oaks, CA 91320.
Mou KY; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158.; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan 11529.
Solomon P; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158.
Aggarwal R; Department of Medicine, University of California, San Francisco, CA 94158.
Leung KK; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158.
Wells JA; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158; .; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Jan 26; Vol. 118 (4).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Bispecific/*pharmacology
B-Lymphocytes/*drug effects
B7 Antigens/*genetics
Epithelial Cells/*drug effects
Proto-Oncogene Proteins c-myc/*genetics
Receptors, TNF-Related Apoptosis-Inducing Ligand/*genetics
Antibodies, Bispecific/biosynthesis ; B-Lymphocytes/immunology ; B-Lymphocytes/pathology ; B7 Antigens/antagonists & inhibitors ; B7 Antigens/immunology ; Cell Engineering/methods ; Cell Line, Tumor ; Cytarabine/pharmacology ; Epithelial Cells/immunology ; Epithelial Cells/pathology ; Gene Expression Regulation, Neoplastic ; Humans ; Immunosuppressive Agents/pharmacology ; Immunotherapy/methods ; Male ; Molecular Targeted Therapy/methods ; Plasmids/chemistry ; Plasmids/metabolism ; Prostate/immunology ; Prostate/pathology ; Protein Binding ; Proto-Oncogene Proteins c-myc/immunology ; Receptors, TNF-Related Apoptosis-Inducing Ligand/antagonists & inhibitors ; Receptors, TNF-Related Apoptosis-Inducing Ligand/immunology ; Signal Transduction ; TNF-Related Apoptosis-Inducing Ligand/pharmacology ; Transfection
Czasopismo naukowe
Tytuł :
A multi-omics approach to Epstein-Barr virus immortalization of B-cells reveals EBNA1 chromatin pioneering activities targeting nucleotide metabolism.
Autorzy :
Lamontagne RJ; The Wistar Institute, Philadelphia, Pennsylvania, United States of America.
Soldan SS; The Wistar Institute, Philadelphia, Pennsylvania, United States of America.
Su C; The Wistar Institute, Philadelphia, Pennsylvania, United States of America.
Wiedmer A; The Wistar Institute, Philadelphia, Pennsylvania, United States of America.
Won KJ; Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark.
Lu F; The Wistar Institute, Philadelphia, Pennsylvania, United States of America.
Goldman AR; The Wistar Institute, Philadelphia, Pennsylvania, United States of America.
Wickramasinghe J; The Wistar Institute, Philadelphia, Pennsylvania, United States of America.
Tang HY; The Wistar Institute, Philadelphia, Pennsylvania, United States of America.
Speicher DW; The Wistar Institute, Philadelphia, Pennsylvania, United States of America.
Showe L; The Wistar Institute, Philadelphia, Pennsylvania, United States of America.
Kossenkov AV; The Wistar Institute, Philadelphia, Pennsylvania, United States of America.
Lieberman PM; The Wistar Institute, Philadelphia, Pennsylvania, United States of America.
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Źródło :
PLoS pathogens [PLoS Pathog] 2021 Jan 26; Vol. 17 (1), pp. e1009208. Date of Electronic Publication: 2021 Jan 26 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Transformation, Viral*
B-Lymphocytes/*pathology
Chromatin/*genetics
Epstein-Barr Virus Infections/*pathology
Epstein-Barr Virus Nuclear Antigens/*metabolism
Nucleotides/*metabolism
Viral Proteins/*metabolism
B-Lymphocytes/metabolism ; B-Lymphocytes/virology ; Chromatin/metabolism ; Epigenesis, Genetic ; Epstein-Barr Virus Infections/metabolism ; Epstein-Barr Virus Infections/virology ; Epstein-Barr Virus Nuclear Antigens/genetics ; Herpesvirus 4, Human/physiology ; Host-Pathogen Interactions ; Humans ; Metabolome ; Transcriptome ; Viral Proteins/genetics
Czasopismo naukowe
Tytuł :
The thioredoxin-1 inhibitor Txnip restrains effector T-cell and germinal center B-cell expansion.
Autorzy :
Muri J; Institute of Molecular Health Sciences, ETH Zürich, Zürich, Switzerland.
Thut H; Institute of Molecular Health Sciences, ETH Zürich, Zürich, Switzerland.
Kopf M; Institute of Molecular Health Sciences, ETH Zürich, Zürich, Switzerland.
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Źródło :
European journal of immunology [Eur J Immunol] 2021 Jan; Vol. 51 (1), pp. 115-124. Date of Electronic Publication: 2020 Sep 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
B-Lymphocytes/*immunology
B-Lymphocytes/*metabolism
Carrier Proteins/*immunology
T-Lymphocytes/*immunology
T-Lymphocytes/*metabolism
Thioredoxins/*antagonists & inhibitors
Thioredoxins/*immunology
Animals ; B-Lymphocytes/cytology ; Carrier Proteins/genetics ; Carrier Proteins/metabolism ; Cell Proliferation ; Germinal Center/cytology ; Germinal Center/immunology ; Germinal Center/metabolism ; In Vitro Techniques ; Lymphocyte Activation ; Lymphocytic Choriomeningitis/immunology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; Oxidation-Reduction ; T-Lymphocytes/cytology ; Thioredoxins/genetics ; Thioredoxins/metabolism
Czasopismo naukowe
Tytuł :
Use of Toll-Like Receptor (TLR) Ligation to Characterize Human Regulatory B-Cells Subsets.
Autorzy :
Chayé MAM; Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands.
Tontini C; Allergy Unit, Department of Internal Medicine, University Hospital of Ancona, Ancona, Italy.
Ozir-Fazalalikhan A; Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands.
Voskamp AL; Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands.
Smits HH; Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands. .
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2270, pp. 235-261.
Typ publikacji :
Journal Article
MeSH Terms :
B-Lymphocytes, Regulatory/*cytology
Flow Cytometry/*methods
Toll-Like Receptors/*immunology
Autoimmunity/immunology ; B-Lymphocytes, Regulatory/immunology ; B-Lymphocytes, Regulatory/metabolism ; Cell Differentiation/immunology ; Humans ; Immune Tolerance/immunology ; Immunity, Innate/immunology ; Interleukin-10/immunology ; Lymphocyte Activation/immunology
Czasopismo naukowe
Tytuł :
Dysregulation in B-cell responses and T follicular helper cell function in ADA2 deficiency patients.
Autorzy :
Schena F; Unità Operativa Semplice Dipartimentale Centro Malattie Autoinfiammatorie e Immunodeficienze, IRCCS Istituto Giannina Gaslini, Genova, Italy.
Penco F; Unità Operativa Semplice Dipartimentale Centro Malattie Autoinfiammatorie e Immunodeficienze, IRCCS Istituto Giannina Gaslini, Genova, Italy.
Volpi S; Unità Operativa Semplice Dipartimentale Centro Malattie Autoinfiammatorie e Immunodeficienze, IRCCS Istituto Giannina Gaslini, Genova, Italy.; Dipartimento di Neuroscienze, riabilitazione, oftalmologia, genetica e scienze materno-infantili (DINOGMI), Università degli studi di Genova, Genova, Italy.
Pastorino C; Unità Operativa Semplice Dipartimentale Centro Malattie Autoinfiammatorie e Immunodeficienze, IRCCS Istituto Giannina Gaslini, Genova, Italy.
Caorsi R; Unità Operativa Clinica Pediatrica e Reumatologia, IRCCS Istituto Giannina Gaslini, Genova, Italy.
Kalli F; Center of Excellence for Biomedical Research/Department of Internal Medicine, Università di Genova, Genova, Italy.
Fenoglio D; Center of Excellence for Biomedical Research/Department of Internal Medicine, Università di Genova, Genova, Italy.; Ospedale Policlinico San Martino, Genova, Italy.
Salis A; Department of Experimental Medicine and Center of Excellence for Biomedical Research, Università di Genova, Genova, Italy.
Bertoni A; Unità Operativa Semplice Dipartimentale Centro Malattie Autoinfiammatorie e Immunodeficienze, IRCCS Istituto Giannina Gaslini, Genova, Italy.
Prigione I; Unità Operativa Semplice Dipartimentale Centro Malattie Autoinfiammatorie e Immunodeficienze, IRCCS Istituto Giannina Gaslini, Genova, Italy.
Bocca P; Unità Operativa Semplice Dipartimentale Centro Malattie Autoinfiammatorie e Immunodeficienze, IRCCS Istituto Giannina Gaslini, Genova, Italy.
Insalaco A; Division of Rheumatology, Department of Pediatric Medicine, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.
De Benedetti F; Division of Rheumatology, Department of Pediatric Medicine, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.
Antonini F; Core Facilities Flow-Cytometry and Cell Imaging Laboratory, IRCCS Istituto Giannina Gaslini, Genova, Italy.
Grossi A; UOSD Laboratory of Genetics and Genomics of Rare Diseases, IRCCS Istituto Giannina Gaslini, Genova, Italy.
Signa S; Unità Operativa Semplice Dipartimentale Centro Malattie Autoinfiammatorie e Immunodeficienze, IRCCS Istituto Giannina Gaslini, Genova, Italy.; Dipartimento di Neuroscienze, riabilitazione, oftalmologia, genetica e scienze materno-infantili (DINOGMI), Università degli studi di Genova, Genova, Italy.
Damonte G; Department of Experimental Medicine and Center of Excellence for Biomedical Research, Università di Genova, Genova, Italy.
Ceccherini I; UOSD Laboratory of Genetics and Genomics of Rare Diseases, IRCCS Istituto Giannina Gaslini, Genova, Italy.
Filaci G; Center of Excellence for Biomedical Research/Department of Internal Medicine, Università di Genova, Genova, Italy.; Biotherapy Unit, IRCCS Ospedale Policlinico San Martino, Genova, Italy.
Traggiai E; Novartis Institutes for Biomedical Research, Basel, Switzerland.
Gattorno M; Unità Operativa Semplice Dipartimentale Centro Malattie Autoinfiammatorie e Immunodeficienze, IRCCS Istituto Giannina Gaslini, Genova, Italy.; Unità Operativa Clinica Pediatrica e Reumatologia, IRCCS Istituto Giannina Gaslini, Genova, Italy.
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Źródło :
European journal of immunology [Eur J Immunol] 2021 Jan; Vol. 51 (1), pp. 206-219. Date of Electronic Publication: 2020 Aug 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adenosine Deaminase/*deficiency
Agammaglobulinemia/*immunology
B-Lymphocytes/*immunology
Intercellular Signaling Peptides and Proteins/*deficiency
Severe Combined Immunodeficiency/*immunology
T Follicular Helper Cells/*immunology
Adenosine Deaminase/genetics ; Adenosine Deaminase/immunology ; Adolescent ; Adult ; Agammaglobulinemia/enzymology ; Agammaglobulinemia/genetics ; B-Lymphocytes/enzymology ; B-Lymphocytes/pathology ; Case-Control Studies ; Cell Differentiation ; Cell Proliferation ; Child ; Child, Preschool ; Female ; Humans ; Immunologic Memory ; Immunophenotyping ; In Vitro Techniques ; Infant ; Infant, Newborn ; Intercellular Signaling Peptides and Proteins/genetics ; Intercellular Signaling Peptides and Proteins/immunology ; Interleukins/biosynthesis ; Lymphocyte Activation ; Male ; Mutation ; Severe Combined Immunodeficiency/enzymology ; Severe Combined Immunodeficiency/genetics ; T Follicular Helper Cells/pathology
SCR Disease Name :
Severe combined immunodeficiency due to adenosine deaminase deficiency
Czasopismo naukowe
Tytuł :
B-Cell Commitment to IL-10 Production: The VertX Il10 Mouse.
Autorzy :
Oka A; Center for Gastrointestinal Biology and Disease, Department of Medicine, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Internal Medicine II, Shimane University Faculty of Medicine, Izumo, Shimane, Japan.
Liu B; Center for Gastrointestinal Biology and Disease, Department of Medicine, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Herzog JW; Center for Gastrointestinal Biology and Disease, Department of Medicine, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Sartor RB; Center for Gastrointestinal Biology and Disease, Department of Medicine, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. .; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. .; National Gnotobiotic Rodent Resource Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. .
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2270, pp. 341-358.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
B-Lymphocytes, Regulatory/*pathology
Genes, Reporter/*genetics
Interleukin-10/*analysis
Animals ; B-Lymphocytes, Regulatory/cytology ; B-Lymphocytes, Regulatory/immunology ; Colitis/pathology ; Cytokines ; Female ; Gene Expression/genetics ; Green Fluorescent Proteins/genetics ; Interleukin-10/immunology ; Intestines/pathology ; Lymph Nodes/cytology ; Male ; Mice ; Mice, Inbred C57BL ; Models, Animal ; Spleen/cytology ; T-Lymphocytes, Regulatory/pathology
Czasopismo naukowe
Tytuł :
Artesunate inhibits Sjögren's syndrome-like autoimmune responses and BAFF-induced B cell hyperactivation via TRAF6-mediated NF-κB signaling.
Autorzy :
Zhan T; Department of Oral Surgery, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China; National Clinical Research Center of Oral Disease, Shanghai, China; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai, China.
Wang B; Department of Oral Surgery, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China; National Clinical Research Center of Oral Disease, Shanghai, China; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai, China.
Fu J; Department of Oral Surgery, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China; National Clinical Research Center of Oral Disease, Shanghai, China; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai, China.
Shao Y; Department of Oral Surgery, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China; National Clinical Research Center of Oral Disease, Shanghai, China; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai, China.
Ye L; Department of Oral Surgery, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China; National Clinical Research Center of Oral Disease, Shanghai, China; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai, China.
Shi H; Department of Oral Surgery, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China; National Clinical Research Center of Oral Disease, Shanghai, China; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai, China. Electronic address: .
Zheng L; Department of Oral Surgery, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China; National Clinical Research Center of Oral Disease, Shanghai, China; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai, China. Electronic address: .
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Źródło :
Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2021 Jan; Vol. 80, pp. 153381. Date of Electronic Publication: 2020 Oct 13.
Typ publikacji :
Journal Article
MeSH Terms :
Artesunate/*pharmacology
B-Cell Activating Factor/*pharmacology
B-Lymphocytes/*drug effects
Immunologic Factors/*pharmacology
Sjogren's Syndrome/*immunology
Animals ; Autoantibodies/metabolism ; Autoimmunity/drug effects ; B-Cell Activating Factor/metabolism ; B-Lymphocytes/immunology ; B-Lymphocytes/metabolism ; B-Lymphocytes/pathology ; Cell Line, Tumor ; Disease Models, Animal ; Humans ; Intracellular Signaling Peptides and Proteins/metabolism ; Lymphocytes/drug effects ; Mice, Inbred ICR ; Mice, Inbred NOD ; NF-kappa B/metabolism ; Salivary Glands/drug effects ; Salivary Glands/metabolism ; Signal Transduction/drug effects ; Sjogren's Syndrome/drug therapy ; Sjogren's Syndrome/pathology
Czasopismo naukowe
Tytuł :
9-cis Retinoic acid and 1.25-dihydroxyvitamin D 3 drive differentiation into IgA secreting plasmablasts in human naïve B cells.
Autorzy :
Treptow S; Division of Allergy and Immunology, Klinik für Dermatologie, Venerologie und Allergologie, CCM, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Grün J; Deutsches Rheuma-Forschungszentrum Berlin, Berlin, Germany.
Scholz J; Division of Allergy and Immunology, Klinik für Dermatologie, Venerologie und Allergologie, CCM, Charité - Universitätsmedizin Berlin, Berlin, Germany.; Deutsches Rheuma-Forschungszentrum Berlin, Berlin, Germany.
Radbruch A; Deutsches Rheuma-Forschungszentrum Berlin, Berlin, Germany.
Heine G; Division of Allergy and Immunology, Klinik für Dermatologie, Venerologie und Allergologie, CCM, Charité - Universitätsmedizin Berlin, Berlin, Germany.; Department of Dermatology and Allergy, University Hospital Schleswig-Holstein, Campus Kiel, Germany.
Worm M; Division of Allergy and Immunology, Klinik für Dermatologie, Venerologie und Allergologie, CCM, Charité - Universitätsmedizin Berlin, Berlin, Germany.; Deutsches Rheuma-Forschungszentrum Berlin, Berlin, Germany.
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Źródło :
European journal of immunology [Eur J Immunol] 2021 Jan; Vol. 51 (1), pp. 125-137. Date of Electronic Publication: 2020 Dec 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alitretinoin/*immunology
Alitretinoin/*pharmacology
B-Lymphocytes/*drug effects
B-Lymphocytes/*immunology
Calcitriol/*immunology
Calcitriol/*pharmacology
Immunoglobulin A/*biosynthesis
Adaptive Immunity/drug effects ; B-Lymphocytes/cytology ; Binding Sites/genetics ; CD40 Ligand/immunology ; Cell Differentiation/drug effects ; Cell Differentiation/immunology ; Cells, Cultured ; GTP-Binding Proteins/genetics ; Gene Expression ; Humans ; Immunoglobulin Class Switching/drug effects ; Immunoglobulin Class Switching/immunology ; Interleukin-4/immunology ; Ligands ; Lymphocyte Activation ; Plasma Cells/cytology ; Plasma Cells/drug effects ; Plasma Cells/immunology ; Promoter Regions, Genetic ; Receptors, Calcitriol/immunology ; Receptors, Retinoic Acid/immunology ; Retinoid X Receptors/immunology ; Signal Transduction/immunology ; Transforming Growth Factor beta1/biosynthesis ; Transforming Growth Factor beta1/genetics ; Transglutaminases/genetics ; Vitamin D3 24-Hydroxylase/genetics
Czasopismo naukowe
Tytuł :
Deficiency of Wiskott-Aldrich syndrome protein has opposing effect on the pro-oncogenic pathway activation in nonmalignant versus malignant lymphocytes.
Autorzy :
Han SS; Division of Pediatric Hematology-Oncology, Carver College of Medicine and the Stead Family University of Iowa Children's Hospital, Iowa City, IA, 52242, USA.
Wen KK; Division of Pediatric Hematology-Oncology, Carver College of Medicine and the Stead Family University of Iowa Children's Hospital, Iowa City, IA, 52242, USA.
Vyas YM; Division of Pediatric Hematology-Oncology, Carver College of Medicine and the Stead Family University of Iowa Children's Hospital, Iowa City, IA, 52242, USA. .
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Źródło :
Oncogene [Oncogene] 2021 Jan; Vol. 40 (2), pp. 345-354. Date of Electronic Publication: 2020 Nov 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
B-Lymphocytes/*pathology
Oncogene Proteins/*metabolism
T-Lymphocytes/*pathology
Tumor Suppressor Proteins/*metabolism
Wiskott-Aldrich Syndrome/*pathology
Wiskott-Aldrich Syndrome Protein/*deficiency
B-Lymphocytes/immunology ; B-Lymphocytes/metabolism ; Cell Proliferation ; Cells, Cultured ; Humans ; Mitogen-Activated Protein Kinase 1/metabolism ; Mitogen-Activated Protein Kinase 3/metabolism ; NF-kappa B/metabolism ; Signal Transduction ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; Transcription Factor AP-1/metabolism ; Wiskott-Aldrich Syndrome/immunology ; Wiskott-Aldrich Syndrome/metabolism ; cdc42 GTP-Binding Protein/metabolism
Czasopismo naukowe
Tytuł :
Super-enhancers for RUNX3 are required for cell proliferation in EBV-infected B cell lines.
Autorzy :
Hosoi H; Cancer Science Institute of Singapore, National University of Singapore, Singapore; Department of Hematology/Oncology, Wakayama Medical University, Wakayama, Japan.
Niibori-Nambu A; Cancer Science Institute of Singapore, National University of Singapore, Singapore; Department of Tumor Genetics and Biology, Graduate School of Medical Sciences, Institute of Life Sciences, Kumamoto University, Kumamoto, Japan.
Nah GSS; Cancer Science Institute of Singapore, National University of Singapore, Singapore.
Bahirvani AG; Cancer Science Institute of Singapore, National University of Singapore, Singapore.
Mok MMH; Cancer Science Institute of Singapore, National University of Singapore, Singapore.
Sanda T; Cancer Science Institute of Singapore, National University of Singapore, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Kumar AP; Cancer Science Institute of Singapore, National University of Singapore, Singapore; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Cancer Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Tenen DG; Cancer Science Institute of Singapore, National University of Singapore, Singapore; Harvard Stem Cell Institute, Harvard Medical School, Boston, MA, USA.
Ito Y; Cancer Science Institute of Singapore, National University of Singapore, Singapore.
Sonoki T; Department of Hematology/Oncology, Wakayama Medical University, Wakayama, Japan. Electronic address: .
Osato M; Cancer Science Institute of Singapore, National University of Singapore, Singapore; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; International Research Center for Medical Sciences, Kumamoto University, Japan. Electronic address: .
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Źródło :
Gene [Gene] 2021 Mar 30; Vol. 774, pp. 145421. Date of Electronic Publication: 2021 Jan 12.
Typ publikacji :
Journal Article
MeSH Terms :
Enhancer Elements, Genetic*
B-Lymphocytes/*virology
Cell Proliferation/*genetics
Core Binding Factor Alpha 3 Subunit/*genetics
Herpesvirus 4, Human/*physiology
Azepines/pharmacology ; B-Lymphocytes/cytology ; Burkitt Lymphoma/genetics ; Burkitt Lymphoma/virology ; CRISPR-Cas Systems ; Cell Line ; Cell Line, Tumor ; Cell Proliferation/drug effects ; G1 Phase/drug effects ; Gene Expression Regulation/drug effects ; Genes, myc ; Humans ; Protein Domains ; Proteins/antagonists & inhibitors ; Proteins/metabolism ; Triazoles/pharmacology
Czasopismo naukowe
Tytuł :
The Interaction of Human and Epstein-Barr Virus miRNAs with Multiple Sclerosis Risk Loci.
Autorzy :
Afrasiabi A; Systems Biology and Health Data Analytics Lab, The Graduate School of Biomedical Engineering, UNSW Sydney, Sydney, NSW 2052, Australia.; EBV Molecular Lab, Centre for Immunology and Allergy Research, Westmead Institute for Medical Research, University of Sydney, Westmead, NSW 2145, Australia.
Fewings NL; EBV Molecular Lab, Centre for Immunology and Allergy Research, Westmead Institute for Medical Research, University of Sydney, Westmead, NSW 2145, Australia.
Schibeci SD; EBV Molecular Lab, Centre for Immunology and Allergy Research, Westmead Institute for Medical Research, University of Sydney, Westmead, NSW 2145, Australia.
Keane JT; EBV Molecular Lab, Centre for Immunology and Allergy Research, Westmead Institute for Medical Research, University of Sydney, Westmead, NSW 2145, Australia.
Booth DR; EBV Molecular Lab, Centre for Immunology and Allergy Research, Westmead Institute for Medical Research, University of Sydney, Westmead, NSW 2145, Australia.
Parnell GP; EBV Molecular Lab, Centre for Immunology and Allergy Research, Westmead Institute for Medical Research, University of Sydney, Westmead, NSW 2145, Australia.
Swaminathan S; EBV Molecular Lab, Centre for Immunology and Allergy Research, Westmead Institute for Medical Research, University of Sydney, Westmead, NSW 2145, Australia.; Department of Medicine, Western Sydney University, Sydney, NSW 2560, Australia.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Mar 13; Vol. 22 (6). Date of Electronic Publication: 2021 Mar 13.
Typ publikacji :
Journal Article
MeSH Terms :
Genetic Loci*
B-Lymphocytes/*virology
Host-Pathogen Interactions/*genetics
MicroRNAs/*genetics
RNA, Messenger/*genetics
RNA-Binding Proteins/*genetics
Alleles ; B-Lymphocytes/immunology ; Base Sequence ; Gene Expression Regulation ; Host-Pathogen Interactions/immunology ; Humans ; Interferon-gamma/genetics ; Interferon-gamma/immunology ; MicroRNAs/immunology ; Models, Biological ; Multiple Sclerosis/genetics ; Multiple Sclerosis/immunology ; Multiple Sclerosis/pathology ; Multiple Sclerosis/virology ; Polymorphism, Single Nucleotide ; Primary Cell Culture ; RNA, Messenger/immunology ; RNA-Binding Proteins/immunology ; Signal Transduction
Czasopismo naukowe
Tytuł :
Pertussis Toxin Inhibits Encephalitogenic T-Cell Infiltration and Promotes a B-Cell-Driven Disease during Th17-EAE.
Autorzy :
Maria Z; Department of Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.
Turner E; Department of Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.; Department of Animal and Food Sciences, Oklahoma State University, Stillwater, OK 74078, USA.
Agasing A; Department of Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.
Kumar G; Department of Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.
Axtell RC; Department of Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Mar 13; Vol. 22 (6). Date of Electronic Publication: 2021 Mar 13.
Typ publikacji :
Journal Article
MeSH Terms :
B-Lymphocytes/*pathology
Encephalomyelitis, Autoimmune, Experimental/*pathology
Pertussis Toxin/*administration & dosage
Th17 Cells/*pathology
Adoptive Transfer/methods ; Animals ; B-Lymphocytes/immunology ; Cell Movement/immunology ; Encephalomyelitis, Autoimmune, Experimental/chemically induced ; Encephalomyelitis, Autoimmune, Experimental/immunology ; Encephalomyelitis, Autoimmune, Experimental/mortality ; Female ; Humans ; Kaplan-Meier Estimate ; Mice ; Mice, Inbred C57BL ; Multiple Sclerosis/immunology ; Multiple Sclerosis/pathology ; Myelin-Oligodendrocyte Glycoprotein/administration & dosage ; Severity of Illness Index ; Th17 Cells/immunology ; Th17 Cells/transplantation
Czasopismo naukowe
Tytuł :
Complement-Opsonized Nano-Carriers Are Bound by Dendritic Cells (DC) via Complement Receptor (CR)3, and by B Cell Subpopulations via CR-1/2, and Affect the Activation of DC and B-1 Cells.
Autorzy :
Bednarczyk M; Department of Dermatology, University Medical Center Mainz, Langenbeckstraße 1, 55131 Mainz, Germany.
Medina-Montano C; Department of Dermatology, University Medical Center Mainz, Langenbeckstraße 1, 55131 Mainz, Germany.
Fittler FJ; Department of Dermatology, University Medical Center Mainz, Langenbeckstraße 1, 55131 Mainz, Germany.
Stege H; Department of Dermatology, University Medical Center Mainz, Langenbeckstraße 1, 55131 Mainz, Germany.
Roskamp M; Miltenyi Biotec GmbH, Friedrich-Ebert-Strasse 68, 51429 Bergisch Gladbach, Germany.
Kuske M; Department of Dermatology, University Medical Center Mainz, Langenbeckstraße 1, 55131 Mainz, Germany.
Langer C; Miltenyi Biotec GmbH, Friedrich-Ebert-Strasse 68, 51429 Bergisch Gladbach, Germany.
Vahldieck M; Miltenyi Biotec GmbH, Friedrich-Ebert-Strasse 68, 51429 Bergisch Gladbach, Germany.
Montermann E; Department of Dermatology, University Medical Center Mainz, Langenbeckstraße 1, 55131 Mainz, Germany.
Tubbe I; Department of Dermatology, University Medical Center Mainz, Langenbeckstraße 1, 55131 Mainz, Germany.
Röhrig N; Department of Dermatology, University Medical Center Mainz, Langenbeckstraße 1, 55131 Mainz, Germany.
Dzionek A; Miltenyi Biotec GmbH, Friedrich-Ebert-Strasse 68, 51429 Bergisch Gladbach, Germany.
Grabbe S; Department of Dermatology, University Medical Center Mainz, Langenbeckstraße 1, 55131 Mainz, Germany.
Bros M; Department of Dermatology, University Medical Center Mainz, Langenbeckstraße 1, 55131 Mainz, Germany.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Mar 11; Vol. 22 (6). Date of Electronic Publication: 2021 Mar 11.
Typ publikacji :
Journal Article
MeSH Terms :
B-Lymphocyte Subsets/*immunology
B-Lymphocytes/*immunology
CD11b Antigen/*immunology
Complement System Proteins/*immunology
Dendritic Cells/*immunology
Receptors, Complement/*immunology
Animals ; B-Lymphocyte Subsets/metabolism ; B-Lymphocytes/metabolism ; CD11b Antigen/genetics ; CD11b Antigen/metabolism ; Cells, Cultured ; Complement Activation/immunology ; Complement System Proteins/metabolism ; Dendritic Cells/metabolism ; Dextrans/chemistry ; Drug Carriers/chemistry ; Humans ; Lymphocyte Activation/immunology ; Mice, Inbred C57BL ; Mice, Knockout ; Nanoparticles/chemistry ; Opsonin Proteins/immunology ; Opsonin Proteins/metabolism ; Phagocytosis/immunology ; Receptors, Complement/metabolism
Czasopismo naukowe
Tytuł :
Immune Memory in Mild COVID-19 Patients and Unexposed Donors Reveals Persistent T Cell Responses After SARS-CoV-2 Infection.
Autorzy :
Ansari A; Vaccine Immunology Laboratory, National Institute of Immunology, New Delhi, India.
Arya R; Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India.
Sachan S; Vaccine Immunology Laboratory, National Institute of Immunology, New Delhi, India.
Jha SN; Vaccine Immunology Laboratory, National Institute of Immunology, New Delhi, India.
Kalia A; Vaccine Immunology Laboratory, National Institute of Immunology, New Delhi, India.
Lall A; Department of Transfusion Medicine, All India Institute of Medical Sciences, New Delhi, India.
Sette A; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, United States.; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego, La Jolla, CA, United States.
Grifoni A; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, United States.
Weiskopf D; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, United States.
Coshic P; Department of Transfusion Medicine, All India Institute of Medical Sciences, New Delhi, India.
Sharma A; Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India.
Gupta N; Vaccine Immunology Laboratory, National Institute of Immunology, New Delhi, India.
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Źródło :
Frontiers in immunology [Front Immunol] 2021 Mar 11; Vol. 12, pp. 636768. Date of Electronic Publication: 2021 Mar 11 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunologic Memory*
B-Lymphocytes/*immunology
CD4-Positive T-Lymphocytes/*immunology
COVID-19/*immunology
SARS-CoV-2/*immunology
Spike Glycoprotein, Coronavirus/*immunology
Adult ; Antibodies, Neutralizing/blood ; Antibodies, Viral/blood ; B-Lymphocytes/virology ; CD4-Positive T-Lymphocytes/virology ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/virology ; COVID-19/blood ; COVID-19/diagnosis ; COVID-19/virology ; Case-Control Studies ; Female ; Humans ; Immunity, Cellular ; Male ; Middle Aged ; Time Factors ; Young Adult
Czasopismo naukowe
Tytuł :
The dichotomous and incomplete adaptive immunity in COVID-19 patients with different disease severity.
Autorzy :
Gao L; Institute of Immunology, Third Military Medical University, Chongqing, China.
Zhou J; Institute of Immunology, Third Military Medical University, Chongqing, China.
Yang S; Chongqing Public Health Medical Center, Chongqing, China.
Wang L; Institute of Immunology, Third Military Medical University, Chongqing, China.
Chen X; Institute of Immunology, Third Military Medical University, Chongqing, China.
Yang Y; Institute of Immunology, Third Military Medical University, Chongqing, China.
Li R; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, Heilongjiang, China.; College of Veterinary Medicine, Northeast Agricultural University, Harbin, Heilongjiang, China.
Pan Z; Institute of Immunology, Third Military Medical University, Chongqing, China.
Zhao J; Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Li Z; Institute of Immunology, Third Military Medical University, Chongqing, China.
Huang Q; Cancer Center, The General Hospital of Western Theater Command, Chengdu, Sichuan, China.
Tang J; Institute of Immunology, Third Military Medical University, Chongqing, China.
Hu L; Institute of Immunology, Third Military Medical University, Chongqing, China.
Liu P; Comparative Immunology Research Center, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Zhang G; Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, China. .
Chen Y; Chongqing Public Health Medical Center, Chongqing, China. .
Ye L; Institute of Immunology, Third Military Medical University, Chongqing, China. .
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Źródło :
Signal transduction and targeted therapy [Signal Transduct Target Ther] 2021 Mar 08; Vol. 6 (1), pp. 113. Date of Electronic Publication: 2021 Mar 08.
Typ publikacji :
Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adaptive Immunity*
B-Lymphocytes/*immunology
CD8-Positive T-Lymphocytes/*immunology
COVID-19/*immunology
SARS-CoV-2/*immunology
Th1 Cells/*immunology
Adult ; B-Lymphocytes/pathology ; CD8-Positive T-Lymphocytes/pathology ; COVID-19/pathology ; Female ; Humans ; Male ; Severity of Illness Index ; Th1 Cells/pathology
Czasopismo naukowe
Tytuł :
Alarmin-activated B cells accelerate murine atherosclerosis after myocardial infarction via plasma cell-immunoglobulin-dependent mechanisms.
Autorzy :
Kyaw T; Vascular Biology and Atherosclerosis, Baker Heart and Diabetes Institute, 75 Commercial Road, Melbourne, VIC 3004, Australia.; Centre for Inflammatory Diseases, Department of Medicine, Medical Centre, 246 Clayton Road, Clayton, VIC 3168, Australia.
Loveland P; Vascular Biology and Atherosclerosis, Baker Heart and Diabetes Institute, 75 Commercial Road, Melbourne, VIC 3004, Australia.
Kanellakis P; Vascular Biology and Atherosclerosis, Baker Heart and Diabetes Institute, 75 Commercial Road, Melbourne, VIC 3004, Australia.
Cao A; Vascular Biology and Atherosclerosis, Baker Heart and Diabetes Institute, 75 Commercial Road, Melbourne, VIC 3004, Australia.; Centre for Inflammatory Diseases, Department of Medicine, Medical Centre, 246 Clayton Road, Clayton, VIC 3168, Australia.
Kallies A; Department of Microbiology and Immunology, University of Melbourne, 792 Elizabeth Street, Melbourne, Vic 3000, Australia.
Huang AL; Atherothrombosis and Vascular Biology, Baker Heart and Diabetes Institute, 75 Commercial Road, Melbourne, VIC 3004, Australia.; Department of Cardiology, Alfred Hospital, 55 Commercial Rd, Melbourne, VIC 3004, Australia.
Peter K; Atherothrombosis and Vascular Biology, Baker Heart and Diabetes Institute, 75 Commercial Road, Melbourne, VIC 3004, Australia.; Department of Cardiology, Alfred Hospital, 55 Commercial Rd, Melbourne, VIC 3004, Australia.; Department of Immunology, Central Clinical School, 99 Commercial Rd, Melbourne, VIC 3004, Australia.
Toh BH; Centre for Inflammatory Diseases, Department of Medicine, Medical Centre, 246 Clayton Road, Clayton, VIC 3168, Australia.
Bobik A; Vascular Biology and Atherosclerosis, Baker Heart and Diabetes Institute, 75 Commercial Road, Melbourne, VIC 3004, Australia.; Centre for Inflammatory Diseases, Department of Medicine, Medical Centre, 246 Clayton Road, Clayton, VIC 3168, Australia.; Department of Immunology, Central Clinical School, 99 Commercial Rd, Melbourne, VIC 3004, Australia.
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Źródło :
European heart journal [Eur Heart J] 2021 Mar 01; Vol. 42 (9), pp. 938-947.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alarmins*
Atherosclerosis*/etiology
B-Lymphocytes*
Myocardial Infarction*
Plaque, Atherosclerotic*
Animals ; Disease Models, Animal ; Mice ; Mice, Inbred C57BL ; Mice, Knockout, ApoE ; Plasma Cells
Czasopismo naukowe
Tytuł :
Artemisinin attenuates IgM xenoantibody production via inhibition of T cell-independent marginal zone B cell proliferation.
Autorzy :
Liu L; Department of Traditional Chinese Medicine, The Fifth Affiliated Hospital, University of Sun Yat-sen, Zhuhai, P. R. China.
Zhao J; Department of Pharmacy, The Fifth Affiliated Hospital, University of Sun Yat-sen, Zhuhai, P. R. China.
Li A; Department of Traditional Chinese Medicine, The Fifth Affiliated Hospital, University of Sun Yat-sen, Zhuhai, P. R. China.
Yang X; Department of Traditional Chinese Medicine, The Fifth Affiliated Hospital, University of Sun Yat-sen, Zhuhai, P. R. China.
Sprangers B; Department of Microbiology and Immunology, Laboratory of Molecular Immunology (Rega institute), KU Leuven, Leuven, Belgium.
Li S; Department of Traditional Chinese Medicine, The Fifth Affiliated Hospital, University of Sun Yat-sen, Zhuhai, P. R. China.; Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital, University of Sun Yat-sen, Zhuhai, P. R. China.
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Źródło :
Journal of leukocyte biology [J Leukoc Biol] 2021 Mar; Vol. 109 (3), pp. 583-591. Date of Electronic Publication: 2020 Jun 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Heterophile/*biosynthesis
Artemisinins/*pharmacology
B-Lymphocytes/*cytology
Immunoglobulin M/*biosynthesis
T-Lymphocytes/*immunology
Animals ; Antibody Formation/drug effects ; Antigens, CD/metabolism ; B-Lymphocytes/drug effects ; Cell Proliferation/drug effects ; Interleukin-10/metabolism ; Lymphocyte Subsets/cytology ; Lymphocyte Subsets/drug effects ; Male ; Mice, Inbred BALB C ; Mice, Nude ; Spleen/immunology ; T-Lymphocytes/drug effects
Czasopismo naukowe
Tytuł :
Distinct functional properties of secretory l-asparaginase Rv1538c involved in phagosomal survival of Mycobacterium tuberculosis.
Autorzy :
Kataria A; Kusuma School of Biological Sciences, IIT Delhi, Hauz Khas, New Delhi, India, 110016.
Patel AK; Kusuma School of Biological Sciences, IIT Delhi, Hauz Khas, New Delhi, India, 110016.
Kundu B; Kusuma School of Biological Sciences, IIT Delhi, Hauz Khas, New Delhi, India, 110016. Electronic address: .
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Źródło :
Biochimie [Biochimie] 2021 Mar; Vol. 182, pp. 1-12. Date of Electronic Publication: 2021 Jan 05.
Typ publikacji :
Journal Article
MeSH Terms :
Asparaginase*/chemistry
Asparaginase*/genetics
Asparaginase*/metabolism
Bacterial Proteins*/chemistry
Bacterial Proteins*/genetics
Bacterial Proteins*/metabolism
Microbial Viability*
Mycobacterium tuberculosis*/enzymology
Mycobacterium tuberculosis*/genetics
B-Lymphocytes/*microbiology
Phagosomes/*microbiology
B-Lymphocytes/metabolism ; Humans ; Phagosomes/metabolism ; THP-1 Cells
Czasopismo naukowe
Tytuł :
Notch2-mediated plasticity between marginal zone and follicular B cells.
Autorzy :
Lechner M; Research Unit Gene Vectors, Helmholtz Zentrum München GmbH, German Research Center for Environmental Health, München, Germany.
Engleitner T; TranslaTUM, Center for Translational Cancer Research, Technical University of Munich, München, Germany.; Institute of Molecular Oncology and Functional Genomics, TUM School of Medicine, Technical University of Munich, Munich, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.
Babushku T; Research Unit Gene Vectors, Helmholtz Zentrum München GmbH, German Research Center for Environmental Health, München, Germany.
Schmidt-Supprian M; TranslaTUM, Center for Translational Cancer Research, Technical University of Munich, München, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; Institute of Experimental Hematology, TUM School of Medicine, Technical University of Munich, Munich, Germany.
Rad R; TranslaTUM, Center for Translational Cancer Research, Technical University of Munich, München, Germany.; Institute of Molecular Oncology and Functional Genomics, TUM School of Medicine, Technical University of Munich, Munich, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.
Strobl LJ; Research Unit Gene Vectors, Helmholtz Zentrum München GmbH, German Research Center for Environmental Health, München, Germany.
Zimber-Strobl U; Research Unit Gene Vectors, Helmholtz Zentrum München GmbH, German Research Center for Environmental Health, München, Germany. .
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Źródło :
Nature communications [Nat Commun] 2021 Feb 17; Vol. 12 (1), pp. 1111. Date of Electronic Publication: 2021 Feb 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
B-Lymphocytes/*metabolism
Cell Differentiation/*genetics
Gene Expression Profiling/*methods
Receptor, Notch2/*genetics
Signal Transduction/*genetics
Spleen/*metabolism
Animals ; B-Lymphocytes/cytology ; Calcium-Binding Proteins/genetics ; Calcium-Binding Proteins/metabolism ; Cells, Cultured ; Female ; Male ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; Precursor Cells, B-Lymphoid/cytology ; Precursor Cells, B-Lymphoid/metabolism ; Receptor, Notch2/metabolism ; Spleen/cytology
Czasopismo naukowe
Tytuł :
Pseurotin D Inhibits the Activation of Human Lymphocytes.
Autorzy :
Rubanova D; Institute of Biophysics of the Czech Academy of Sciences, 612 65 Brno, Czech Republic.; Department of Experimental Biology, Faculty of Science, Masaryk University, 625 00 Brno, Czech Republic.
Dadova P; Institute of Biophysics of the Czech Academy of Sciences, 612 65 Brno, Czech Republic.; Department of Experimental Biology, Faculty of Science, Masaryk University, 625 00 Brno, Czech Republic.
Vasicek O; Institute of Biophysics of the Czech Academy of Sciences, 612 65 Brno, Czech Republic.; Department of Experimental Biology, Faculty of Science, Masaryk University, 625 00 Brno, Czech Republic.
Kubala L; Institute of Biophysics of the Czech Academy of Sciences, 612 65 Brno, Czech Republic.; Department of Experimental Biology, Faculty of Science, Masaryk University, 625 00 Brno, Czech Republic.; International Clinical Research Center, St. Anne's University Hospital, 656 91 Brno, Czech Republic.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Feb 16; Vol. 22 (4). Date of Electronic Publication: 2021 Feb 16.
Typ publikacji :
Journal Article
MeSH Terms :
Antigens, CD19/*metabolism
B-Lymphocytes/*immunology
CD4-Positive T-Lymphocytes/*immunology
CD8-Positive T-Lymphocytes/*immunology
Immunologic Factors/*pharmacology
Lymphocyte Activation/*drug effects
Pyrrolidinones/*pharmacology
Adolescent ; Adult ; Apoptosis/drug effects ; B-Lymphocytes/drug effects ; CD4-Positive T-Lymphocytes/drug effects ; CD8-Positive T-Lymphocytes/drug effects ; Cell Differentiation/drug effects ; Cells, Cultured ; Female ; Healthy Volunteers ; Humans ; Male ; Middle Aged ; Signal Transduction/drug effects ; Tumor Necrosis Factor-alpha/metabolism ; Young Adult
Czasopismo naukowe

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