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Tytuł :
Immunomodulatory Drugs for the Treatment of B Cell Malignancies.
Autorzy :
Ioannou N; Faculty of Life Sciences & Medicine, School of Cancer & Pharmaceutical Sciences, King's College London, London SE1 9RT, UK.
Jain K; Faculty of Life Sciences & Medicine, School of Cancer & Pharmaceutical Sciences, King's College London, London SE1 9RT, UK.
Ramsay AG; Faculty of Life Sciences & Medicine, School of Cancer & Pharmaceutical Sciences, King's College London, London SE1 9RT, UK.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Aug 09; Vol. 22 (16). Date of Electronic Publication: 2021 Aug 09.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antineoplastic Agents/*therapeutic use
Enzyme Inhibitors/*therapeutic use
Immunologic Factors/*therapeutic use
Lymphoma, B-Cell/*drug therapy
Adaptor Proteins, Signal Transducing/antagonists & inhibitors ; Adaptor Proteins, Signal Transducing/immunology ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy ; Leukemia, Lymphocytic, Chronic, B-Cell/immunology ; Lymphoma, B-Cell/immunology ; Neoplasm Proteins/antagonists & inhibitors ; Neoplasm Proteins/immunology ; Ubiquitin-Protein Ligases/antagonists & inhibitors ; Ubiquitin-Protein Ligases/immunology
Czasopismo naukowe
Tytuł :
BAFF receptor antibody for mantle cell lymphoma therapy.
Autorzy :
Zhang K; Division of Hematology/Oncology, Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Roy NK; Division of Hematology/Oncology, Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Vicioso Y; Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA.
Woo J; Novartis Institute for BioMedical Research, Translational Clinical Oncology, NJ, USA.
Beck R; Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA.
de Lima M; Hematology and Oncology, University Hospitals, Cleveland, Ohio, USA.; The Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Caimi P; Hematology and Oncology, University Hospitals, Cleveland, Ohio, USA.; The Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Feinberg D; Division of Hematology/Oncology, Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Parameswaran R; Division of Hematology/Oncology, Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.; The Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
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Źródło :
Oncoimmunology [Oncoimmunology] 2021 Mar 05; Vol. 10 (1), pp. 1893501. Date of Electronic Publication: 2021 Mar 05.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
B-Cell Activation Factor Receptor*/genetics
Lymphoma, Mantle-Cell*/drug therapy
Antibodies, Monoclonal, Humanized/*therapeutic use
Animals ; Apoptosis ; B-Cell Activating Factor/genetics ; Humans ; Mice ; Neoplasm Recurrence, Local
Czasopismo naukowe
Tytuł :
Antibody Peptides as Cancer Vaccine-Turning Weapons to Targets.
Autorzy :
Seiffert M; Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany. .
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Źródło :
Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2021 Feb 01; Vol. 27 (3), pp. 659-661. Date of Electronic Publication: 2020 Dec 02.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Cancer Vaccines*
Leukemia, Lymphocytic, Chronic, B-Cell*/therapy
Animals ; Antibodies ; Humans ; Mice ; Peptides ; Receptors, Antigen, B-Cell
Czasopismo naukowe
Tytuł :
FcγRIIb-BCR coligation inhibits BCR signaling in chronic lymphocytic leukemia.
Autorzy :
Bosch R; Laboratory of Oncology/Hematology and Transplantation, IIB Sant Pau, Barcelona.
Mora A; Laboratory of Oncology/Hematology and Transplantation, IIB Sant Pau, Barcelona.
Cuellar C; Department of Hematology, Hospital de la Santa Creu i Sant Pau, Barcelona.
Ferrer G; Karches Center for Oncology Research, The Feinstein Institute for Medical Research.
Gorlatov S; MacroGenics, Inc., Rockville, MD.
Nomdedéu J; Laboratory of Hematology, Hospital de la Santa Creu i Sant Pau, Barcelona.
Montserrat E; Department of Hematology, Hospital Clínic, IDIBAPS, Barcelona.
Sierra J; Department of Hematology, Hospital de la Santa Creu i Sant Pau, Barcelona.
Rai KR; Karches Center for Oncology Research, The Feinstein Institute for Medical Research.
Chiorazzi N; Karches Center for Oncology Research, The Feinstein Institute for Medical Research.
Moreno C; Department of Hematology, Hospital de la Santa Creu i Sant Pau, Barcelona.
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Źródło :
Haematologica [Haematologica] 2021 Jan 01; Vol. 106 (1), pp. 306-309. Date of Electronic Publication: 2021 Jan 01.
Typ publikacji :
Letter; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Leukemia, Lymphocytic, Chronic, B-Cell*/genetics
Humans ; Receptors, Antigen, B-Cell/genetics ; Signal Transduction
Raport
Tytuł :
Outcomes of Richter's transformation of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL): an analysis of the SEER database.
Autorzy :
Elnair R; Division of Oncology and Hematology, University of Nebraska Medical Center, Omaha, NE, 68198, USA. .
Ellithi M; Department of Internal Medicine, Sanford School of Medicine, University of South Dakota, Vermillion, SD, USA.
Kallam A; Division of Oncology and Hematology, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Shostrom V; College of Public Health, Department of Biostatistics, University of Nebraska Medical Center, Omaha, NE, USA.
Bociek RG; Division of Oncology and Hematology, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
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Źródło :
Annals of hematology [Ann Hematol] 2021 Oct; Vol. 100 (10), pp. 2513-2519. Date of Electronic Publication: 2021 Jul 19.
Typ publikacji :
Journal Article
MeSH Terms :
Leukemia, Lymphocytic, Chronic, B-Cell/*pathology
Aged ; Cell Transformation, Neoplastic/pathology ; Disease Progression ; Female ; Hodgkin Disease/diagnosis ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/complications ; Leukemia, Lymphocytic, Chronic, B-Cell/diagnosis ; Lymphoma, Large B-Cell, Diffuse/diagnosis ; Male ; Middle Aged ; Prognosis
Czasopismo naukowe
Tytuł :
The role of 18F-FDG-PET in detecting Richter's transformation of chronic lymphocytic leukemia in patients receiving therapy with a B-cell receptor inhibitor.
Autorzy :
Wang Y; Division of Hematology, Mayo Clinic, Rochester, MN, USA.
Rabe KG; Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA.
Bold MS; Department of Radiology, Mayo Clinic, Rochester, MN, USA.
Shi M; Division of Hematopathology, Mayo Clinic, Rochester, MN, USA.
Hanson CA; Division of Hematopathology, Mayo Clinic, Rochester, MN, USA.
Schwager SM; Division of Hematology, Mayo Clinic, Rochester, MN, USA.
Call TG; Division of Hematology, Mayo Clinic, Rochester, MN, USA.
Kenderian SS; Division of Hematology, Mayo Clinic, Rochester, MN, USA.
Muchtar E; Division of Hematology, Mayo Clinic, Rochester, MN, USA.
Hayman SR; Division of Hematology, Mayo Clinic, Rochester, MN, USA.
Koehler AB; Division of Hematology, Mayo Clinic, Rochester, MN, USA.
Fonder AL; Division of Hematology, Mayo Clinic, Rochester, MN, USA.
Chanan-Khan AA; Division of Hematology and Medical Oncology, Mayo Clinic, Jacksonville, FL, USA.
Van Dyke DL; Division of Laboratory Genetics and Genomics, Mayo Clinic, Rochester, MN, USA.
Slager SL; Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA.
Kay NE; Division of Hematology, Mayo Clinic, Rochester, MN, USA.
Ding W; Division of Hematology, Mayo Clinic, Rochester, MN, USA.
Leis JF; Division of Hematology and Medical Oncology, Mayo Clinic, Phoenix, AZ, USA.
Parikh SA; Division of Hematology, Mayo Clinic, Rochester, MN, USA.
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Źródło :
Haematologica [Haematologica] 2020 Nov 01; Vol. 105 (11), pp. 2675-2678. Date of Electronic Publication: 2020 Nov 01.
Typ publikacji :
Letter; Research Support, N.I.H., Extramural
MeSH Terms :
Leukemia, Lymphocytic, Chronic, B-Cell*/diagnostic imaging
Leukemia, Lymphocytic, Chronic, B-Cell*/drug therapy
Lymphoma, Large B-Cell, Diffuse*
Cell Transformation, Neoplastic ; Fluorodeoxyglucose F18 ; Humans ; Positron-Emission Tomography ; Receptors, Antigen, B-Cell
Raport
Tytuł :
Constitutive activation of Lyn kinase enhances BCR responsiveness, but not the development of CLL in Eµ-TCL1 mice.
Autorzy :
Kohlhas V
Hallek M
Nguyen PH
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Źródło :
Blood advances [Blood Adv] 2020 Dec 22; Vol. 4 (24), pp. 6106-6116.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Leukemia, Lymphocytic, Chronic, B-Cell*/drug therapy
Leukemia, Lymphocytic, Chronic, B-Cell*/genetics
Animals ; Mice ; Mice, Transgenic ; Protein-Tyrosine Kinases ; Proto-Oncogene Proteins ; Receptors, Antigen, B-Cell/genetics ; Signal Transduction
Czasopismo naukowe
Tytuł :
IRF4 modulates the response to BCR activation in chronic lymphocytic leukemia regulating IKAROS and SYK.
Autorzy :
Maffei R; Hematology Unit, Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy. .; Hematology Unit, Department of Oncology and Hematology, A.O.U of Modena, Policlinico, Modena, Italy. .
Fiorcari S; Hematology Unit, Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy.
Benatti S; Hematology Unit, Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy.
Atene CG; Hematology Unit, Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy.
Martinelli S; Hematology Unit, Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy.
Zucchini P; Hematology Unit, Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy.
Potenza L; Hematology Unit, Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy.
Luppi M; Hematology Unit, Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy.
Marasca R; Hematology Unit, Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy.
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Źródło :
Leukemia [Leukemia] 2021 May; Vol. 35 (5), pp. 1330-1343. Date of Electronic Publication: 2021 Feb 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Ikaros Transcription Factor/*genetics
Interferon Regulatory Factors/*genetics
Leukemia, Lymphocytic, Chronic, B-Cell/*genetics
Syk Kinase/*genetics
Antineoplastic Agents/pharmacology ; Cell Line ; Cell Line, Tumor ; Down-Regulation/genetics ; Humans ; Lenalidomide/pharmacology ; Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy ; Leukocytes, Mononuclear/drug effects ; Receptors, Antigen, B-Cell ; Signal Transduction/genetics ; Spleen/drug effects
Czasopismo naukowe
Tytuł :
The Traf2 DNx BCL2-tg Mouse Model of Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Recapitulates the Biased IGHV Gene Usage, Stereotypy, and Antigen-Specific HCDR3 Selection of Its Human Counterpart.
Autorzy :
Perez-Chacon G; Instituto de Investigaciones Biomédicas 'Alberto Sols', CSIC-UAM, Madrid, Spain.; Instituto de Investigación Hospital Universitario La Paz (IDIPAZ), Madrid, Spain.
Zapata JM; Instituto de Investigaciones Biomédicas 'Alberto Sols', CSIC-UAM, Madrid, Spain.; Instituto de Investigación Hospital Universitario La Paz (IDIPAZ), Madrid, Spain.
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Źródło :
Frontiers in immunology [Front Immunol] 2021 Apr 12; Vol. 12, pp. 627602. Date of Electronic Publication: 2021 Apr 12 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genes, Immunoglobulin Heavy Chain*
Complementarity Determining Regions/*genetics
Immunoglobulin Variable Region/*genetics
Leukemia, Lymphocytic, Chronic, B-Cell/*immunology
Animals ; Complementarity Determining Regions/chemistry ; Disease Models, Animal ; Female ; Humans ; Infant ; Leukemia, Lymphocytic, Chronic, B-Cell/genetics ; Male ; Mice ; Mice, Inbred BALB C ; Mutation ; Proto-Oncogene Proteins c-bcl-2/genetics ; Receptors, Antigen, B-Cell/genetics ; Receptors, Antigen, B-Cell/immunology ; Somatic Hypermutation, Immunoglobulin ; TNF Receptor-Associated Factor 2/genetics
Czasopismo naukowe
Tytuł :
Genome-wide DNA methylation analysis along the progression of gastric marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) type.
Autorzy :
Dugge R; Institute of Pathology, Ulm University, Ulm, Germany.
Wagener R; Ulm University Medical Center, Institute of Human Genetics, Ulm University, Ulm, Germany.
Mӧller P; Institute of Pathology, Ulm University, Ulm, Germany.
Barth TFE; Institute of Pathology, Ulm University, Ulm, Germany.
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Źródło :
British journal of haematology [Br J Haematol] 2021 Apr; Vol. 193 (2), pp. 369-374. Date of Electronic Publication: 2021 Feb 16.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gastritis/*etiology
Helicobacter Infections/*complications
Lymphoma, B-Cell, Marginal Zone/*genetics
Lymphoma, Non-Hodgkin/*genetics
Stomach Neoplasms/*genetics
B-Lymphocytes/pathology ; DNA Methylation ; Disease Progression ; Extranodal Extension/pathology ; Gastritis/microbiology ; Genome-Wide Association Study ; Humans ; Lymphoma, B-Cell, Marginal Zone/diagnosis ; Lymphoma, B-Cell, Marginal Zone/pathology ; Lymphoma, Large B-Cell, Diffuse/pathology ; Lymphoma, Non-Hodgkin/diagnosis ; Lymphoma, Non-Hodgkin/pathology ; Stomach Neoplasms/diagnosis ; Stomach Neoplasms/pathology
SCR Disease Name :
Familial primary gastric lymphoma
Czasopismo naukowe
Tytuł :
Safety of venetoclax rapid dose escalation in CLL patients previously treated with B-cell receptor signaling antagonists.
Autorzy :
Koenig KL; Division of Hematology and.
Huang Y; Division of Hematology and.
Dotson EK; Department of Pharmacy, The Ohio State University, Columbus, OH; and.
Sheredy S; Department of Pharmacy, The Ohio State University, Columbus, OH; and.
Bhat SA; Division of Hematology and.
Byrd JC; Division of Hematology and.
Desmond E; Division of Hematology and.
Ford J; Division of Hematology and.
Iarocci S; Division of Hematology and.
Jones JA; Division of Hematology and.
Lucas MS; Division of Hematology and.
Moran ME; Division of Hematology and.
Wiczer TE; Department of Pharmacy, The Ohio State University, Columbus, OH; and.
Woyach JA; Division of Hematology and.
Awan FT; Division of Hematology and Oncology, University of Texas Southwestern Medical Center, Dallas, TX.
Rogers KA; Division of Hematology and.
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Źródło :
Blood advances [Blood Adv] 2020 Oct 13; Vol. 4 (19), pp. 4860-4863.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents*/therapeutic use
Leukemia, Lymphocytic, Chronic, B-Cell*/drug therapy
Bridged Bicyclo Compounds, Heterocyclic/adverse effects ; Humans ; Receptors, Antigen, B-Cell ; Sulfonamides
Czasopismo naukowe
Tytuł :
Active Akt signaling triggers CLL toward Richter transformation via overactivation of Notch1.
Autorzy :
Kohlhaas V; Max Planck Institute for Metabolism Research, Cologne, Germany.; Institute for Genetics, University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), Cologne, Germany.; Center for Endocrinology, Diabetes and Preventive Medicine (CEDP) Cologne, Cologne, Germany.
Blakemore SJ; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), Cologne, Germany.; Department I of Internal Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
Al-Maarri M; Max Planck Institute for Metabolism Research, Cologne, Germany.; Institute for Genetics, University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), Cologne, Germany.; Center for Endocrinology, Diabetes and Preventive Medicine (CEDP) Cologne, Cologne, Germany.
Nickel N; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), Cologne, Germany.; Department I of Internal Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
Pal M; Max Planck Institute for Metabolism Research, Cologne, Germany.; Institute for Genetics, University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), Cologne, Germany.; Center for Endocrinology, Diabetes and Preventive Medicine (CEDP) Cologne, Cologne, Germany.
Roth A; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), Cologne, Germany.; Department I of Internal Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
Hövelmeyer N; Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg, University Mainz, Mainz, Germany.
Schäfer SC; Institute of Pathology.
Knittel G; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), Cologne, Germany.; Department I of Internal Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
Lohneis P; Institute of Pathology.
Nikolic M; Center for Molecular Medicine Cologne (CMMC), Cologne, Germany.; Department of Translational Genomics, and.
Wiederstein JL; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany.; Department of Translational Genomics, and.
Franitza M; Cologne Center for Genomics (CCG), University of Cologne, Cologne, Germany.
Georgomonolis T; Cologne Center for Genomics (CCG), University of Cologne, Cologne, Germany.; West German Genome Center (WGGC), Cologne, Germany.
Reinart N; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), Cologne, Germany.; Department I of Internal Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
Herling M; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), Cologne, Germany.; Department I of Internal Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
Herling C; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), Cologne, Germany.; Department I of Internal Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
Hartmann EM; Institute of Pathology, University of Würzburg, and Comprehensive Cancer Center Mainfranken, Würzburg, Germany.
Rosenwald A; Institute of Pathology, University of Würzburg, and Comprehensive Cancer Center Mainfranken, Würzburg, Germany.
Klapper W; Department of Pathology, University Hospital of Schleswig-Holstein, Kiel, Germany.
Büttner R; Institute of Pathology.
Moia R; Division of Pathology, Department of Health Science, University of Piemonte Orientale (UPO), Novara, Italy.
Rossi D; Division of Hematology, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.; Laboratory of Experimental Hematology, Institute of Oncology Research, Bellinzona, Switzerland.
Boldorini R; Division of Pathology, Department of Health Science, University of Piemonte Orientale (UPO), Novara, Italy.; Università del Piemonte Orientale, Department of Translational Medicine, Novara, Italy; and.
Gaidano G; Università del Piemonte Orientale, Department of Translational Medicine, Novara, Italy; and.
Frenzel LP; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), Cologne, Germany.; Department I of Internal Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
Reinhardt HC; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), Cologne, Germany.; Department I of Internal Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.; Clinic for Hematology and Stem Cell Transplant, University Hospital of Essen, Essen, Germany.
Brüning JC; Max Planck Institute for Metabolism Research, Cologne, Germany.; Institute for Genetics, University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), Cologne, Germany.; Center for Endocrinology, Diabetes and Preventive Medicine (CEDP) Cologne, Cologne, Germany.
Hallek M; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), Cologne, Germany.; Department I of Internal Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
Krüger M; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany.; Department of Translational Genomics, and.
Peifer M; Center for Molecular Medicine Cologne (CMMC), Cologne, Germany.; Department of Translational Genomics, and.
Pallasch CP; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), Cologne, Germany.; Department I of Internal Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
Wunderlich FT; Max Planck Institute for Metabolism Research, Cologne, Germany.; Institute for Genetics, University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), Cologne, Germany.; Center for Endocrinology, Diabetes and Preventive Medicine (CEDP) Cologne, Cologne, Germany.
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Źródło :
Blood [Blood] 2021 Feb 04; Vol. 137 (5), pp. 646-660.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Leukemia, Lymphocytic, Chronic, B-Cell/*pathology
Lymphoma, Large B-Cell, Diffuse/*pathology
Neoplasm Proteins/*physiology
Proto-Oncogene Proteins c-akt/*physiology
Receptor, Notch1/*physiology
Animals ; Clonal Evolution ; Disease Progression ; Enzyme Activation ; Gene Expression Regulation, Neoplastic ; Genes, p53 ; Leukemia, Lymphocytic, Chronic, B-Cell/genetics ; Leukemia, Lymphocytic, Chronic, B-Cell/physiopathology ; Lymphocytes, Tumor-Infiltrating/immunology ; Lymphoma, Large B-Cell, Diffuse/genetics ; Lymphoma, Large B-Cell, Diffuse/physiopathology ; Mice ; Mice, Inbred C57BL ; Phenotype ; Phosphoproteins/physiology ; Proto-Oncogene Proteins c-akt/genetics ; Receptors, Antigen, B-Cell/immunology ; Signal Transduction/physiology ; Transcriptome ; Tumor Microenvironment ; Tumor Suppressor Protein p53/physiology ; Up-Regulation
Czasopismo naukowe
Tytuł :
Bacterial Infection and Non-Hodgkin B-Cell Lymphoma: Interactions between Pathogen, Host and the Tumor Environment.
Autorzy :
Biernat MM; Department of Haematology, Blood Neoplasms and Bone Marrow Transplantation, Wroclaw Medical University, 50-367 Wroclaw, Poland.
Wróbel T; Department of Haematology, Blood Neoplasms and Bone Marrow Transplantation, Wroclaw Medical University, 50-367 Wroclaw, Poland.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jul 09; Vol. 22 (14). Date of Electronic Publication: 2021 Jul 09.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Host-Pathogen Interactions*/genetics
Host-Pathogen Interactions*/immunology
Bacterial Infections/*complications
Burkitt Lymphoma/*microbiology
Helicobacter Infections/*microbiology
Lymphoma, B-Cell, Marginal Zone/*microbiology
Lymphoma, Large B-Cell, Diffuse/*microbiology
Bacterial Infections/immunology ; Burkitt Lymphoma/complications ; Burkitt Lymphoma/pathology ; Carcinogenesis/genetics ; Carcinogenesis/immunology ; Carcinogenesis/metabolism ; Helicobacter Infections/complications ; Helicobacter pylori/pathogenicity ; Humans ; Lymphoma, B-Cell, Marginal Zone/complications ; Lymphoma, B-Cell, Marginal Zone/pathology ; Lymphoma, Large B-Cell, Diffuse/complications ; Lymphoma, Large B-Cell, Diffuse/pathology ; Tumor Microenvironment/genetics ; Tumor Microenvironment/immunology
Czasopismo naukowe
Tytuł :
Frequent loss of CD10 expression in follicular lymphoma with leukaemic presentation.
Autorzy :
Chen SW; Lioying Chi-Mei Hospital, Department of Internal Medicine, Division of Hemato-Oncology, Tainan, Taiwan. .
Chang ST
Hsieh YC
Kuo CC
Wu HC
Feng YH
Chuang SS
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Źródło :
The Malaysian journal of pathology [Malays J Pathol] 2020 Aug; Vol. 42 (2), pp. 237-243.
Typ publikacji :
Journal Article
MeSH Terms :
Leukemia, B-Cell*/metabolism
Leukemia, B-Cell*/pathology
Lymphoma, Follicular*/metabolism
Lymphoma, Follicular*/pathology
Neprilysin/*metabolism
Adult ; Aged ; Female ; Flow Cytometry ; Humans ; Immunohistochemistry ; In Situ Hybridization, Fluorescence ; Leukemia, Lymphocytic, Chronic, B-Cell/metabolism ; Male ; Middle Aged ; Prognosis ; Survival Rate
Czasopismo naukowe
Tytuł :
BIRD-2, a BH4-domain-targeting peptide of Bcl-2, provokes Bax/Bak-independent cell death in B-cell cancers through mitochondrial Ca -dependent mPTP opening.
Autorzy :
Kerkhofs M; Laboratory of Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine, Leuven Cancer Institute (LKI), KU Leuven, Campus Gasthuisberg O/N-1 Bus 802, Herestraat 49, 3000, Leuven, Belgium.
La Rovere R; Laboratory of Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine, Leuven Cancer Institute (LKI), KU Leuven, Campus Gasthuisberg O/N-1 Bus 802, Herestraat 49, 3000, Leuven, Belgium.
Welkenhuysen K; Laboratory of Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine, Leuven Cancer Institute (LKI), KU Leuven, Campus Gasthuisberg O/N-1 Bus 802, Herestraat 49, 3000, Leuven, Belgium.
Janssens A; Department of Hematology, UZ Leuven, Leuven, Belgium.
Vandenberghe P; Department of Hematology, UZ Leuven, Leuven, Belgium; Department of Human Genetics, KU Leuven, Leuven, Belgium.
Madesh M; Department of Medicine/Cardiology, Institute for Precision Medicine and Health, University of Texas Health San Antonio, San Antonio, TX 78229, United States.
Parys JB; Laboratory of Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine, Leuven Cancer Institute (LKI), KU Leuven, Campus Gasthuisberg O/N-1 Bus 802, Herestraat 49, 3000, Leuven, Belgium.
Bultynck G; Laboratory of Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine, Leuven Cancer Institute (LKI), KU Leuven, Campus Gasthuisberg O/N-1 Bus 802, Herestraat 49, 3000, Leuven, Belgium. Electronic address: .
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Źródło :
Cell calcium [Cell Calcium] 2021 Mar; Vol. 94, pp. 102333. Date of Electronic Publication: 2021 Jan 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Calcium/*metabolism
Lymphoma, B-Cell/*pathology
Mitochondria/*metabolism
Mitochondrial Permeability Transition Pore/*metabolism
Peptides/*chemistry
Peptides/*pharmacology
bcl-2 Homologous Antagonist-Killer Protein/*metabolism
bcl-2-Associated X Protein/*metabolism
Bcl-2-Like Protein 11/metabolism ; Calcium Signaling/drug effects ; Calpain/metabolism ; Caspases/metabolism ; Cell Death/drug effects ; Cell Line, Tumor ; Enzyme Activation/drug effects ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/pathology ; Lymphoma, B-Cell/enzymology ; Lymphoma, B-Cell/metabolism ; Mitochondria/drug effects ; Protein Domains
Czasopismo naukowe
Tytuł :
Critical requirement for BCR, BAFF, and BAFFR in memory B cell survival.
Autorzy :
Müller-Winkler J; The Francis Crick Institute, London, UK.
Mitter R; The Francis Crick Institute, London, UK.
Rappe JCF; The Francis Crick Institute, London, UK.
Vanes L; The Francis Crick Institute, London, UK.
Schweighoffer E; The Francis Crick Institute, London, UK.
Mohammadi H; The Francis Crick Institute, London, UK.
Wack A; The Francis Crick Institute, London, UK.
Tybulewicz VLJ; The Francis Crick Institute, London, UK.; Imperial College, London, UK.
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Źródło :
The Journal of experimental medicine [J Exp Med] 2021 Feb 01; Vol. 218 (2).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
B-Cell Activating Factor/*immunology
B-Lymphocytes/*immunology
Immunologic Memory/*immunology
Receptors, Antigen, B-Cell/*immunology
Animals ; B-Cell Activation Factor Receptor/immunology ; Cell Survival ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Signal Transduction/immunology
Czasopismo naukowe
Tytuł :
B cell receptor signaling related to resistance to Helicobacter pylori eradication therapy in gastric diffuse large B cell lymphoma.
Autorzy :
Torisu T; Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Kawano S; Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Miyawaki K; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
Yamamoto H; Department of Anatomic Pathology, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan.
Ihara Y; Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Matsuno Y; Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Torisu K; Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Sugio T; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
Sasaki K; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
Shimakawa T; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
Kato K; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
Akashi K; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
Nakamura S; Department of Internal Medicine, Division of Gastroenterology, Iwate Medical University, Morioka, Japan.
Kitazono T; Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
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Źródło :
Hematological oncology [Hematol Oncol] 2021 Feb; Vol. 39 (1), pp. 145-147. Date of Electronic Publication: 2020 Oct 14.
Typ publikacji :
Letter
MeSH Terms :
Drug Resistance, Bacterial*
Helicobacter Infections*/drug therapy
Helicobacter Infections*/metabolism
Helicobacter Infections*/pathology
Lymphoma, Large B-Cell, Diffuse*/drug therapy
Lymphoma, Large B-Cell, Diffuse*/metabolism
Lymphoma, Large B-Cell, Diffuse*/pathology
Signal Transduction*
Stomach Neoplasms*/drug therapy
Stomach Neoplasms*/metabolism
Stomach Neoplasms*/pathology
Helicobacter pylori/*metabolism
Receptors, Antigen, B-Cell/*metabolism
Adult ; Aged ; Antineoplastic Combined Chemotherapy Protocols/administration & dosage ; Cyclophosphamide/administration & dosage ; Doxorubicin/administration & dosage ; Female ; Humans ; Male ; Middle Aged ; Prednisone/administration & dosage ; Retrospective Studies ; Rituximab/administration & dosage ; Vincristine/administration & dosage
Opinia redakcyjna
Tytuł :
Pyruvate dehydrogenase kinase 4-mediated metabolic reprogramming is involved in rituximab resistance in diffuse large B-cell lymphoma by affecting the expression of MS4A1/CD20.
Autorzy :
Jiang D; Department of Hematology, The Third Xiangya Hospital, Central South University, Changsha, China.; Department of Hematology, Affiliated Hospital of Guilin Medical University, Guilin, China.
Mo Q; Department of Hematology, Affiliated Hospital of Guilin Medical University, Guilin, China.
Sun X; Department of Hematology, The Qinghai Provincial People's Hospital, Xining, China.
Wang X; Department of Hematology, Affiliated Hospital of Guilin Medical University, Guilin, China.
Dong M; Department of Hematology, The Second Affiliated Hospital of Hainan Medical University, Haikou, China.
Zhang G; Department of Hematology, Affiliated Hospital of Guilin Medical University, Guilin, China.
Chen F; Department of Hematology, The Third Xiangya Hospital, Central South University, Changsha, China.
Zhao Q; Department of Hematology, The Qinghai Provincial People's Hospital, Xining, China.; Department of Blood Transfusion, The Third Xiangya Hospital, Central South University, Changsha, China.
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Źródło :
Cancer science [Cancer Sci] 2021 Sep; Vol. 112 (9), pp. 3585-3597. Date of Electronic Publication: 2021 Jul 28.
Typ publikacji :
Journal Article
MeSH Terms :
Antigens, CD20/*metabolism
Antineoplastic Agents, Immunological/*administration & dosage
Cellular Reprogramming/*genetics
Drug Resistance, Neoplasm/*genetics
Glycoproteins/*metabolism
Lymphoma, Large B-Cell, Diffuse/*drug therapy
Lymphoma, Large B-Cell, Diffuse/*metabolism
Pyruvate Dehydrogenase Acetyl-Transferring Kinase/*metabolism
Rituximab/*administration & dosage
Signal Transduction/*genetics
Adolescent ; Adult ; Aged ; Animals ; Apoptosis/drug effects ; Apoptosis/genetics ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Proliferation/genetics ; Cell Survival/drug effects ; Cell Survival/genetics ; Drug Resistance, Neoplasm/drug effects ; Female ; Humans ; Lymphoma, Large B-Cell, Diffuse/genetics ; Lymphoma, Large B-Cell, Diffuse/pathology ; Male ; Mice ; Middle Aged ; Pyruvate Dehydrogenase Acetyl-Transferring Kinase/genetics ; Transfection ; Treatment Outcome ; Tumor Burden/drug effects ; Tumor Burden/genetics ; Xenograft Model Antitumor Assays ; Young Adult
Czasopismo naukowe
Tytuł :
Risk stratification model based on VEGF and International Prognostic Index accurately identifies low-risk diffuse large B-cell lymphoma patients in the rituximab era.
Autorzy :
Sang W; Department of Hematology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, Jiangsu, China.
Zhou H; Department of Hematology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, Jiangsu, China.
Qin Y; Department of Hematology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, Jiangsu, China.
Shen Z; Department of Epidemiology and Biostatistics, School of Public Health, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China.
Yan D; Department of Hematology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, Jiangsu, China.
Sun C; Department of Hematology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, Jiangsu, China.
Song X; Department of Hematology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, Jiangsu, China.
Ma Y; Department of Hematology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, Jiangsu, China.
Tu D; Department of Hematology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, Jiangsu, China.
Bian Z; Department of Hematology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, Jiangsu, China.
Nie S; Department of Hematology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, Jiangsu, China.
Jin Y; Department of Epidemiology and Biostatistics, School of Public Health, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China.
Xu L; Department of Hematology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, Jiangsu, China.
Li Z; Department of Hematology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, Jiangsu, China.
Xu K; Department of Hematology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, Jiangsu, China. .
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Źródło :
International journal of hematology [Int J Hematol] 2021 Aug; Vol. 114 (2), pp. 189-198. Date of Electronic Publication: 2021 Apr 24.
Typ publikacji :
Journal Article
MeSH Terms :
Biomarkers, Tumor*
Lymphoma, Large B-Cell, Diffuse/*diagnosis
Lymphoma, Large B-Cell, Diffuse/*metabolism
Vascular Endothelial Growth Factor A/*metabolism
Adult ; Aged ; Aged, 80 and over ; Antineoplastic Agents, Immunological/administration & dosage ; Antineoplastic Agents, Immunological/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Female ; Humans ; Immunohistochemistry ; Lymphoma, Large B-Cell, Diffuse/drug therapy ; Lymphoma, Large B-Cell, Diffuse/etiology ; Male ; Middle Aged ; Molecular Targeted Therapy ; Prognosis ; Rituximab/administration & dosage ; Rituximab/therapeutic use ; Survival Analysis ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Richter's transformation in the heart.
Autorzy :
Marra A; Institute of Hematology and Center of Hemato-Oncology Research (CREO), University and Hospital of Perugia, Perugia, Italy. Electronic address: .
Adamo F; Institute of Hematology and Center of Hemato-Oncology Research (CREO), University and Hospital of Perugia, Perugia, Italy.
Baldoni S; Institute of Hematology and Center of Hemato-Oncology Research (CREO), University and Hospital of Perugia, Perugia, Italy.
Laurenti ME; Division of Anatomic Pathology and Histology, Department of Experimental Medicine, School of Medicine and Surgery, University of Perugia, Perugia, Italy.
Giansanti M; Division of Anatomic Pathology and Histology, Department of Experimental Medicine, School of Medicine and Surgery, University of Perugia, Perugia, Italy.
Pasquino S; Department of Cardiac Surgery, Hospital S.M. della Misericordia, Perugia, Italy.
Bigerna B; Institute of Hematology and Center of Hemato-Oncology Research (CREO), University and Hospital of Perugia, Perugia, Italy.
Sorcini D; Institute of Hematology and Center of Hemato-Oncology Research (CREO), University and Hospital of Perugia, Perugia, Italy.
Stella A; Institute of Hematology and Center of Hemato-Oncology Research (CREO), University and Hospital of Perugia, Perugia, Italy.
Guarente V; Institute of Hematology and Center of Hemato-Oncology Research (CREO), University and Hospital of Perugia, Perugia, Italy.
Limongello R; Institute of Hematology and Center of Hemato-Oncology Research (CREO), University and Hospital of Perugia, Perugia, Italy.
Perriello V; Institute of Hematology and Center of Hemato-Oncology Research (CREO), University and Hospital of Perugia, Perugia, Italy.
Martino G; Institute of Hematology and Center of Hemato-Oncology Research (CREO), University and Hospital of Perugia, Perugia, Italy.
Ascani S; Institute of Hematology and Center of Hemato-Oncology Research (CREO), University and Hospital of Perugia, Perugia, Italy.
Falini B; Institute of Hematology and Center of Hemato-Oncology Research (CREO), University and Hospital of Perugia, Perugia, Italy.
Sportoletti P; Institute of Hematology and Center of Hemato-Oncology Research (CREO), University and Hospital of Perugia, Perugia, Italy.
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Źródło :
The Lancet. Oncology [Lancet Oncol] 2021 Jul; Vol. 22 (7), pp. e341.
Typ publikacji :
Case Reports; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Transformation, Neoplastic/*pathology
Leukemia, Lymphocytic, Chronic, B-Cell/*pathology
Lymphoma, Large B-Cell, Diffuse/*pathology
Myocardium/*pathology
Aged ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Biomarkers, Tumor/genetics ; Cardiac Surgical Procedures ; Cell Transformation, Neoplastic/genetics ; Cell Transformation, Neoplastic/immunology ; Diagnosis, Differential ; Female ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/genetics ; Leukemia, Lymphocytic, Chronic, B-Cell/immunology ; Leukemia, Lymphocytic, Chronic, B-Cell/therapy ; Lymphoma, Large B-Cell, Diffuse/genetics ; Lymphoma, Large B-Cell, Diffuse/immunology ; Lymphoma, Large B-Cell, Diffuse/therapy ; Myocardium/immunology ; Predictive Value of Tests ; Treatment Outcome
Raport

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