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Tytuł :
Soluble PD-L1 Concentration Is Proportional to the Expression of PD-L1 in Tissue and Is Associated with a Poor Prognosis in Esophageal Squamous Cell Carcinoma.
Autorzy :
Shiraishi T; Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
Toyozumi T; Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
Sakata H; Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
Murakami K; Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
Kano M; Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
Matsumoto Y; Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
Yokoyama M; Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
Okada K; Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
Kamata T; Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
Ryuzaki T; Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
Kinoshita K; Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
Hirasawa S; Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
Matsubara H; Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
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Źródło :
Oncology [Oncology] 2022; Vol. 100 (1), pp. 39-47. Date of Electronic Publication: 2021 Dec 06.
Typ publikacji :
Journal Article
MeSH Terms :
B7-H1 Antigen/*metabolism
Biomarkers, Tumor/*metabolism
Esophageal Neoplasms/*metabolism
Esophageal Squamous Cell Carcinoma/*metabolism
Aged ; Animals ; B7-H1 Antigen/blood ; B7-H1 Antigen/genetics ; Biomarkers, Tumor/blood ; Cell Line, Tumor ; Esophageal Neoplasms/mortality ; Esophageal Neoplasms/pathology ; Esophageal Neoplasms/surgery ; Esophageal Squamous Cell Carcinoma/mortality ; Esophageal Squamous Cell Carcinoma/pathology ; Esophageal Squamous Cell Carcinoma/surgery ; Female ; Humans ; Male ; Mice, Inbred BALB C ; Mice, Nude ; Middle Aged ; Prognosis ; Solubility ; Survival Rate ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
A Novel Renoprotective Strategy: Upregulation of PD-L1 Mitigates Cisplatin-Induced Acute Kidney Injury.
Autorzy :
Liu J; Department of Internal Medicine, Division of Nephrology, University of California Davis, Davis, CA 95616, USA.
Yang DC; Department of Internal Medicine, Division of Nephrology, University of California Davis, Davis, CA 95616, USA.; Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of California Davis, Davis, CA 95616, USA.
Zhang J; Department of Internal Medicine, Division of Nephrology, University of California Davis, Davis, CA 95616, USA.; Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of California Davis, Davis, CA 95616, USA.; Comprehensive Cancer Center, University of California Davis, Davis, CA 95616, USA.
Hsu SW; Department of Internal Medicine, Division of Nephrology, University of California Davis, Davis, CA 95616, USA.; Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of California Davis, Davis, CA 95616, USA.
Weiss RH; Department of Internal Medicine, Division of Nephrology, University of California Davis, Davis, CA 95616, USA.; Comprehensive Cancer Center, University of California Davis, Davis, CA 95616, USA.
Chen CH; Department of Internal Medicine, Division of Nephrology, University of California Davis, Davis, CA 95616, USA.; Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of California Davis, Davis, CA 95616, USA.; Comprehensive Cancer Center, University of California Davis, Davis, CA 95616, USA.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Dec 10; Vol. 22 (24). Date of Electronic Publication: 2021 Dec 10.
Typ publikacji :
Journal Article
MeSH Terms :
Acute Kidney Injury*/chemically induced
Acute Kidney Injury*/genetics
Acute Kidney Injury*/metabolism
Acute Kidney Injury*/therapy
B7-H1 Antigen*/biosynthesis
B7-H1 Antigen*/genetics
Gene Transfer Techniques*
Up-Regulation*
Cisplatin/*adverse effects
Epithelial Cells/*metabolism
Kidney Tubules, Proximal/*metabolism
Animals ; CD4-Positive T-Lymphocytes/metabolism ; Cisplatin/pharmacology ; Disease Models, Animal ; Macrophages/metabolism ; Mice
Czasopismo naukowe
Tytuł :
Glucocorticoid receptor regulates PD-L1 and MHC-I in pancreatic cancer cells to promote immune evasion and immunotherapy resistance.
Autorzy :
Deng Y; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Xia X; Department of Breast Surgery, Zhejiang Cancer Hospital, Institute of Cancer and Basic Medicine, Chinese Academy of Sciences, 310022, Hangzhou, Zhejiang, China.
Zhao Y; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Zhao Z; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Martinez C; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Yin W; Department of Pathology, Zhejiang Cancer Hospital, Institute of Cancer and Basic Medicine, Chinese Academy of Sciences, 310022, Hangzhou, Zhejiang, China.
Yao J; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Hang Q; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Wu W; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Zhang J; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Yu Y; Department of Breast Surgery, Zhejiang Cancer Hospital, Institute of Cancer and Basic Medicine, Chinese Academy of Sciences, 310022, Hangzhou, Zhejiang, China.
Xia W; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Yao F; Hubei Hongshan Laboratory, College of Life Science and Technology, College of Biomedicine and Health, Huazhong Agricultural University, 430070, Wuhan, Hubei, China.
Zhao D; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.; The University of Texas MD Anderson UTHealth Graduate School of Biomedical Sciences, Houston, TX, 77030, USA.
Sun Y; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Ying H; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.; The University of Texas MD Anderson UTHealth Graduate School of Biomedical Sciences, Houston, TX, 77030, USA.
Hung MC; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA. .; Graduate Institute of Biomedical Sciences and Center for Molecular Medicine, China Medical University, Taichung, 404, Taiwan. .; Department of Biotechnology, Asia University, Taichung, 413, Taiwan. .
Ma L; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA. .; The University of Texas MD Anderson UTHealth Graduate School of Biomedical Sciences, Houston, TX, 77030, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Dec 06; Vol. 12 (1), pp. 7041. Date of Electronic Publication: 2021 Dec 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
B7-H1 Antigen/*immunology
Carcinoma, Pancreatic Ductal/*immunology
Histocompatibility Antigens Class I/*immunology
Pancreatic Neoplasms/*immunology
Receptors, Glucocorticoid/*immunology
Tumor Escape/*immunology
Animals ; B7-H1 Antigen/genetics ; B7-H1 Antigen/metabolism ; Carcinoma, Pancreatic Ductal/genetics ; Carcinoma, Pancreatic Ductal/therapy ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic ; Histocompatibility Antigens Class I/genetics ; Histocompatibility Antigens Class I/metabolism ; Humans ; Immunoblotting ; Immunotherapy/methods ; Kaplan-Meier Estimate ; Mice, Inbred C57BL ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/therapy ; Receptors, Glucocorticoid/genetics ; Receptors, Glucocorticoid/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Tumor Escape/genetics
Czasopismo naukowe
Tytuł :
Assessment of PD-L1 Expression on Circulating Tumor Cells for Predicting Clinical Outcomes in Patients with Cancer Receiving PD-1/PD-L1 Blockade Therapies.
Autorzy :
Tan Z; Department of Gastrointestinal Oncology, The Fifth Medical Center, Chinese PLA General Hospital, Beijing, People's Republic of China.
Yue C; CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Key Laboratory for Biomedical Effects of Nanomaterial and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing, People's Republic of China.
Ji S; Department of Gastrointestinal Oncology, The Fifth Medical Center, Chinese PLA General Hospital, Beijing, People's Republic of China.
Zhao C; Department of Gastrointestinal Oncology, The Fifth Medical Center, Chinese PLA General Hospital, Beijing, People's Republic of China.
Jia R; Department of Gastrointestinal Oncology, The Fifth Medical Center, Chinese PLA General Hospital, Beijing, People's Republic of China.
Zhang Y; Department of Gastrointestinal Oncology, The Fifth Medical Center, Chinese PLA General Hospital, Beijing, People's Republic of China.
Liu R; Department of Gastrointestinal Oncology, The Fifth Medical Center, Chinese PLA General Hospital, Beijing, People's Republic of China.
Li D; CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Key Laboratory for Biomedical Effects of Nanomaterial and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing, People's Republic of China.
Yu Q; CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Key Laboratory for Biomedical Effects of Nanomaterial and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing, People's Republic of China.
Li P; CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Key Laboratory for Biomedical Effects of Nanomaterial and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing, People's Republic of China.
Hu Z; CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Key Laboratory for Biomedical Effects of Nanomaterial and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing, People's Republic of China.
Yang Y; CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Key Laboratory for Biomedical Effects of Nanomaterial and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing, People's Republic of China.
Xu J; Department of Gastrointestinal Oncology, The Fifth Medical Center, Chinese PLA General Hospital, Beijing, People's Republic of China.
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Źródło :
The oncologist [Oncologist] 2021 Dec; Vol. 26 (12), pp. e2227-e2238. Date of Electronic Publication: 2021 Sep 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
B7-H1 Antigen*/antagonists & inhibitors
B7-H1 Antigen*/metabolism
Immune Checkpoint Inhibitors*
Neoplasms*/diagnosis
Neoplasms*/drug therapy
Neoplastic Cells, Circulating*
Humans ; Immunotherapy
Czasopismo naukowe
Tytuł :
Dynamic CD4 T cell heterogeneity defines subset-specific suppression and PD-L1-blockade-driven functional restoration in chronic infection.
Autorzy :
Snell LM; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada. .; Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA. .
Xu W; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Abd-Rabbo D; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Boukhaled G; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Guo M; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Immunology, University of Toronto, Toronto, ON, Canada.
Macleod BL; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Elsaesser HJ; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Hezaveh K; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Alsahafi N; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Lukhele S; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Nejat S; Toronto General Hospital Research Institute, University Health Network (UHN), Toronto, ON, Canada.
Prabhakaran R; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Epelman S; Department of Immunology, University of Toronto, Toronto, ON, Canada.; Toronto General Hospital Research Institute, University Health Network (UHN), Toronto, ON, Canada.; Peter Munk Cardiac Centre, Ted Rogers Centre for Heart Research, Toronto, ON, Canada.
McGaha TL; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Immunology, University of Toronto, Toronto, ON, Canada.
Brooks DG; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada. .; Department of Immunology, University of Toronto, Toronto, ON, Canada. .
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Źródło :
Nature immunology [Nat Immunol] 2021 Dec; Vol. 22 (12), pp. 1524-1537. Date of Electronic Publication: 2021 Nov 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
B7-H1 Antigen/*antagonists & inhibitors
Immune Checkpoint Inhibitors/*pharmacology
Lymphocyte Activation/*drug effects
Lymphocytic Choriomeningitis/*drug therapy
Lymphocytic choriomeningitis virus/*immunology
Th1 Cells/*drug effects
Adoptive Transfer ; Animals ; B7-H1 Antigen/genetics ; B7-H1 Antigen/metabolism ; Cell Proliferation/drug effects ; Chronic Disease ; Cytokines/metabolism ; Cytotoxicity, Immunologic/drug effects ; Disease Models, Animal ; Female ; Gene Regulatory Networks ; Lymphocytic Choriomeningitis/immunology ; Lymphocytic Choriomeningitis/metabolism ; Lymphocytic Choriomeningitis/virology ; Lymphocytic choriomeningitis virus/pathogenicity ; Mice, Inbred C57BL ; Phenotype ; Programmed Cell Death 1 Receptor/genetics ; Programmed Cell Death 1 Receptor/metabolism ; Receptors, Antigen, T-Cell/genetics ; Receptors, Antigen, T-Cell/metabolism ; Signal Transduction ; Th1 Cells/immunology ; Th1 Cells/metabolism ; Th1 Cells/virology ; Transcriptome
Czasopismo naukowe
Tytuł :
PD-L1 (Programmed Death Ligand 1) Regulates T-Cell Differentiation to Control Adaptive Venous Remodeling.
Autorzy :
Matsubara (松原 裕) Y; Vascular Biology and Therapeutics Program (Y.M., L.G., G.K., J. Liu, J. Langford, M.G., X.G., R.T., B.Y., A.D.).; Department of Surgery and Sciences, Kyushu University, Fukuoka, Japan (Y.M., T.F., M.M.).
Gonzalez L; Vascular Biology and Therapeutics Program (Y.M., L.G., G.K., J. Liu, J. Langford, M.G., X.G., R.T., B.Y., A.D.).
Kiwan G; Vascular Biology and Therapeutics Program (Y.M., L.G., G.K., J. Liu, J. Langford, M.G., X.G., R.T., B.Y., A.D.).
Liu (刘 佳) J; Vascular Biology and Therapeutics Program (Y.M., L.G., G.K., J. Liu, J. Langford, M.G., X.G., R.T., B.Y., A.D.).
Langford J; Vascular Biology and Therapeutics Program (Y.M., L.G., G.K., J. Liu, J. Langford, M.G., X.G., R.T., B.Y., A.D.).
Gao (高 明杰) M; Vascular Biology and Therapeutics Program (Y.M., L.G., G.K., J. Liu, J. Langford, M.G., X.G., R.T., B.Y., A.D.).; Department of Vascular Ultrasonography, Xuanwu Hospital, Capital Medical University, Beijing, China (M.G.).
Gao (高 喜翔) X; Vascular Biology and Therapeutics Program (Y.M., L.G., G.K., J. Liu, J. Langford, M.G., X.G., R.T., B.Y., A.D.).; Department of Vascular Surgery, Xuanwu Hospital, Capital Medical University, Beijing, China (X.G).
Taniguchi (谷口 良輔) R; Vascular Biology and Therapeutics Program (Y.M., L.G., G.K., J. Liu, J. Langford, M.G., X.G., R.T., B.Y., A.D.).; Division of Vascular Surgery, The University of Tokyo, Japan (R.T.).
Yatsula B; Vascular Biology and Therapeutics Program (Y.M., L.G., G.K., J. Liu, J. Langford, M.G., X.G., R.T., B.Y., A.D.).
Furuyama (古山 正) T; Department of Surgery and Sciences, Kyushu University, Fukuoka, Japan (Y.M., T.F., M.M.).
Matsumoto (松本 拓也) T; Department of Vascular Surgery, Kyushu Central Hospital, Fukuoka, Japan (T.M.).
Komori (古森 公浩) K; Division of Vascular Surgery, Department of Surgery, Nagoya University Graduate School of Medicine, Japan (K.K.).
Mori (森 正樹) M; Department of Surgery and Sciences, Kyushu University, Fukuoka, Japan (Y.M., T.F., M.M.).
Dardik A; Vascular Biology and Therapeutics Program (Y.M., L.G., G.K., J. Liu, J. Langford, M.G., X.G., R.T., B.Y., A.D.).; Division of Vascular and Endovascular Surgery, Department of Surgery (A.D.), Yale School of Medicine, New Haven, CT.; Department of Surgery, VA Connecticut Healthcare Systems, West Haven, CT (A.D.).
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Źródło :
Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2021 Dec; Vol. 41 (12), pp. 2909-2922. Date of Electronic Publication: 2021 Oct 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Differentiation*
B7-H1 Antigen/*physiology
T-Lymphocytes/*physiology
Vascular Remodeling/*physiology
Animals ; Antibodies/physiology ; Arteriovenous Shunt, Surgical ; B7-H1 Antigen/antagonists & inhibitors ; B7-H1 Antigen/immunology ; Disease Models, Animal ; Female ; Kidney Failure, Chronic/therapy ; Macrophages/physiology ; Male ; Mice, Nude ; Renal Dialysis
Czasopismo naukowe
Tytuł :
Targeting cryptic-orthosteric site of PD-L1 for inhibitor identification using structure-guided approach.
Autorzy :
Mittal L; Translational Health Science and Technology Institute (THSTI), Faridabad, Haryana, India; Delhi Pharmaceutical Sciences and Research University (DPSRU), New Delhi, India.
Tonk RK; Delhi Pharmaceutical Sciences and Research University (DPSRU), New Delhi, India.
Awasthi A; Translational Health Science and Technology Institute (THSTI), Faridabad, Haryana, India.
Asthana S; Translational Health Science and Technology Institute (THSTI), Faridabad, Haryana, India. Electronic address: .
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Źródło :
Archives of biochemistry and biophysics [Arch Biochem Biophys] 2021 Nov 30; Vol. 713, pp. 109059. Date of Electronic Publication: 2021 Oct 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
B7-H1 Antigen/*antagonists & inhibitors
B7-H1 Antigen/*metabolism
Immune Checkpoint Inhibitors/*metabolism
Small Molecule Libraries/*metabolism
Amino Acid Sequence ; B7-H1 Antigen/chemistry ; Binding Sites ; Humans ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Protein Binding ; Thermodynamics
Czasopismo naukowe
Tytuł :
What Do We Have to Know about PD-L1 Expression in Prostate Cancer? A Systematic Literature Review. Part 4: Experimental Treatments in Pre-Clinical Studies (Cell Lines and Mouse Models).
Autorzy :
Palicelli A; Pathology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy.
Croci S; Clinical Immunology, Allergy and Advanced Biotechnologies Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy.
Bisagni A; Pathology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy.
Zanetti E; Pathology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy.
De Biase D; Department of Pharmacy and Biotechnology (FABIT), University of Bologna, 40126 Bologna, Italy.
Melli B; Fertility Center, Department of Obstetrics and Gynecology, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy.; International Doctorate School in Clinical and Experimental Medicine, University of Modena and Reggio Emilia, 41121 Modena, Italy.
Sanguedolce F; Pathology Unit, Policlinico Riuniti, University of Foggia, 71122 Foggia, Italy.
Ragazzi M; Pathology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy.
Zanelli M; Pathology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy.
Chaux A; Department of Scientific Research, School of Postgraduate Studies, Norte University, Asunción 1614, Paraguay.
Cañete-Portillo S; Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Bonasoni MP; Pathology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy.
Soriano A; Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.; Gastroenterology Division, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy.
Ascani S; Pathology Unit, Azienda Ospedaliera Santa Maria di Terni, University of Perugia, 05100 Terni, Italy.; Haematopathology Unit, CREO, Azienda Ospedaliera di Perugia, University of Perugia, 06129 Perugia, Italy.
Zizzo M; Surgical Oncology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy.
Castro Ruiz C; International Doctorate School in Clinical and Experimental Medicine, University of Modena and Reggio Emilia, 41121 Modena, Italy.; Surgical Oncology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy.
De Leo A; Molecular Diagnostic Unit, Azienda USL Bologna, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, 40138 Bologna, Italy.
Giordano G; Medical Oncology Unit, Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, Italy.
Landriscina M; Medical Oncology Unit, Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, Italy.
Carrieri G; Department of Urology and Renal Transplantation, University of Foggia, 71122 Foggia, Italy.
Cormio L; Department of Urology and Renal Transplantation, University of Foggia, 71122 Foggia, Italy.
Berney DM; Barts Cancer Institute, Queen Mary University of London, London EC1M 5PZ, UK.
Gandhi J; Department of Pathology and Laboratory Medicine, University of Washington, Seattle, WA 98195, USA.
Santandrea G; Pathology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy.; International Doctorate School in Clinical and Experimental Medicine, University of Modena and Reggio Emilia, 41121 Modena, Italy.
Bonacini M; Clinical Immunology, Allergy and Advanced Biotechnologies Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Nov 14; Vol. 22 (22). Date of Electronic Publication: 2021 Nov 14.
Typ publikacji :
Journal Article; Systematic Review
MeSH Terms :
Disease Models, Animal*
B7-H1 Antigen/*immunology
Immunotherapy/*methods
Prostatic Neoplasms/*therapy
Signal Transduction/*immunology
Animals ; B7-H1 Antigen/genetics ; B7-H1 Antigen/metabolism ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic/immunology ; Humans ; Male ; Mice ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/immunology ; Signal Transduction/genetics
Czasopismo naukowe
Tytuł :
CHI3L1 regulates PD-L1 and anti-CHI3L1-PD-1 antibody elicits synergistic antitumor responses.
Autorzy :
Ma B; Department of Molecular Microbiology and Immunology, Brown University, Providence, Rhode Island, USA.
Akosman B; Department of Molecular Microbiology and Immunology, Brown University, Providence, Rhode Island, USA.
Kamle S; Department of Molecular Microbiology and Immunology, Brown University, Providence, Rhode Island, USA.
Lee CM; Department of Molecular Microbiology and Immunology, Brown University, Providence, Rhode Island, USA.
He CH; Department of Molecular Microbiology and Immunology, Brown University, Providence, Rhode Island, USA.
Koo JS; Section of Medical Oncology, Department of Internal Medicine, Yale Cancer Center, Yale School of Medicine, New Haven, Connecticut, USA.
Lee CG; Department of Molecular Microbiology and Immunology, Brown University, Providence, Rhode Island, USA.
Elias JA; Department of Molecular Microbiology and Immunology, Brown University, Providence, Rhode Island, USA.; Department of Medicine, Brown University, Providence, Rhode Island, USA.
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Źródło :
The Journal of clinical investigation [J Clin Invest] 2021 Nov 01; Vol. 131 (21).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Video-Audio Media
MeSH Terms :
Antibodies, Bispecific*/immunology
Antibodies, Bispecific*/pharmacology
Antibodies, Neoplasm*/immunology
Antibodies, Neoplasm*/pharmacology
B7-H1 Antigen*/antagonists & inhibitors
B7-H1 Antigen*/immunology
Chitinase-3-Like Protein 1*/antagonists & inhibitors
Chitinase-3-Like Protein 1*/immunology
Lung Neoplasms*/immunology
Lung Neoplasms*/pathology
Lung Neoplasms*/prevention & control
Lung Neoplasms*/secondary
Neoplasm Proteins*/antagonists & inhibitors
Neoplasm Proteins*/immunology
Animals ; Melanoma, Experimental/drug therapy ; Melanoma, Experimental/immunology ; Melanoma, Experimental/pathology ; Mice ; Mice, Knockout ; Neoplasm Metastasis
Czasopismo naukowe
Tytuł :
[Current landscape of biomarker development for immune checkpoint inhibitors targeting PD-1/PD-L1 pathway in oncology].
Autorzy :
Chaput L; Université Lyon, université Claude-Bernard Lyon 1, faculté de pharmacie de Lyon, ISPB, 69008 Lyon, France.
Jordheim LP; Université Lyon, université Claude-Bernard Lyon 1, faculté de pharmacie de Lyon, ISPB, 69008 Lyon, France; Université Lyon, université Claude-Bernard Lyon 1, INSERM 1052, CNRS 5286, centre Léon-Bérard, centre de recherche en cancérologie de Lyon, 69008 Lyon, France. Electronic address: .
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Transliterated Title :
Un tour d’horizon du développement de biomarqueurs pour les anticorps PD-1 et PD-L1 en cancérologie.
Źródło :
Therapie [Therapie] 2021 Nov-Dec; Vol. 76 (6), pp. 597-615. Date of Electronic Publication: 2021 Jul 16.
Typ publikacji :
Journal Article; Review
MeSH Terms :
B7-H1 Antigen*/therapeutic use
Neoplasms*/drug therapy
Biomarkers ; Humans ; Immune Checkpoint Inhibitors ; Immunotherapy ; Programmed Cell Death 1 Receptor/therapeutic use
Czasopismo naukowe
Tytuł :
Inhibition of PAI-1 Blocks PD-L1 Endocytosis and Improves the Response of Melanoma Cells to Immune Checkpoint Blockade.
Autorzy :
Tseng YJ; Department of Dermatology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City, Taiwan.
Lee CH; Department of Dermatology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City, Taiwan.
Chen WY; Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City, Taiwan.
Yang JL; Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City, Taiwan.
Tzeng HT; Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City, Taiwan. Electronic address: .
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Źródło :
The Journal of investigative dermatology [J Invest Dermatol] 2021 Nov; Vol. 141 (11), pp. 2690-2698.e6. Date of Electronic Publication: 2021 May 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
B7-H1 Antigen/*metabolism
Endocytosis/*drug effects
Immune Checkpoint Inhibitors/*therapeutic use
Indoleacetic Acids/*pharmacology
Melanoma/*drug therapy
Plasminogen Activator Inhibitor 1/*pharmacology
Animals ; B7-H1 Antigen/analysis ; B7-H1 Antigen/antagonists & inhibitors ; Caveolins/physiology ; Humans ; Indoleacetic Acids/therapeutic use ; Melanoma/metabolism ; Mice ; Mice, Inbred C57BL
Czasopismo naukowe
Tytuł :
Dual blockage of PD-L/PD-1 and IL33/ST2 axes slows tumor growth and improves antitumor immunity by boosting NK cells.
Autorzy :
Jovanovic MZ; Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia.
Geller DA; Department of Surgery, University of Pittsburgh, 3459 Fifth Avenue, UPMC Montefiore, 7 South Pittsburgh, PA 15213 2582, USA. Electronic address: .
Gajovic NM; Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia.
Jurisevic MM; Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, SvetozaraMarkovica 69, 34000 Kragujevac, Serbia. Electronic address: .
Arsenijevic NN; Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia.
Jovanovic MM; Department of Abdominal Surgery, Military Medical Academy, Crnotravska 17, 11000 Belgrade, Serbia. Electronic address: .
Supic GM; Institute for Medical Research, Military Medical Academy, Crnotravska 17, 11000 Belgrade, Serbia; Medical Faculty of Military Medical Academy, University of Defense, Crnotravska 17, 11000 Belgrade, Serbia. Electronic address: .
Vojvodic DV; Institute for Medical Research, Military Medical Academy, Crnotravska 17, 11000 Belgrade, Serbia; Medical Faculty of Military Medical Academy, University of Defense, Crnotravska 17, 11000 Belgrade, Serbia. Electronic address: .
Jovanovic IP; Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2022 Jan 15; Vol. 289, pp. 120214. Date of Electronic Publication: 2021 Dec 07.
Typ publikacji :
Journal Article
MeSH Terms :
Immunity, Cellular*
B7-H1 Antigen/*immunology
Colonic Neoplasms/*immunology
Interleukin-1 Receptor-Like 1 Protein/*immunology
Interleukin-33/*immunology
Killer Cells, Natural/*immunology
Programmed Cell Death 1 Receptor/*immunology
Signal Transduction/*immunology
Animals ; B7-H1 Antigen/genetics ; Cell Line, Tumor ; Colonic Neoplasms/genetics ; Interleukin-1 Receptor-Like 1 Protein/genetics ; Interleukin-33/genetics ; Mice ; Mice, Inbred BALB C ; Mice, Knockout ; Programmed Cell Death 1 Receptor/genetics ; Signal Transduction/genetics
Czasopismo naukowe
Tytuł :
Association of PD-L1 gene polymorphisms and circulating sPD-L1 levels with HBV infection susceptibility and related liver disease progression.
Autorzy :
Xuan Hoan N; Department of Molecular Biology, 108 Institute of Clinical Medical and Pharmaceutical Sciences, Hanoi, Viet Nam; Vietnamese-German Center for Medical Research (VG-CARE), Hanoi, Viet Nam. Electronic address: .
Thi Minh Huyen P; Department of Biochemistry, 108 Institute of Clinical Medical and Pharmaceutical Sciences, Hanoi, Viet Nam.
Dinh Tung B; Faculty of Biochemistry, Hanoi Medical University, Hanoi, Viet Nam.
Phuong Giang D; Vietnamese-German Center for Medical Research (VG-CARE), Hanoi, Viet Nam.
Tat Trung N; Vietnamese-German Center for Medical Research (VG-CARE), Hanoi, Viet Nam; Centre for Genetic Consultation and Cancer Screening, 108 Institute of Clinical Medical and Pharmaceutical Sciences, Hanoi, Viet Nam.
Tien Sy B; Vietnamese-German Center for Medical Research (VG-CARE), Hanoi, Viet Nam.
Thi Tuan N; Department of Immunology, 108 Institute of Clinical Medical and Pharmaceutical Sciences, Hanoi, Viet Nam.
Thi Ngoc Dung D; Faculty of Biochemistry, Hanoi Medical University, Hanoi, Viet Nam.
Reddy Pallerla S; Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany.
Velavan TP; Vietnamese-German Center for Medical Research (VG-CARE), Hanoi, Viet Nam; Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany.
Hong Bang M; Vietnamese-German Center for Medical Research (VG-CARE), Hanoi, Viet Nam; Faculty of Gastroenterology, 108 Institute of Clinical Medical and Pharmaceutical Sciences, Hanoi, Viet Nam.
Huu Song L; Department of Molecular Biology, 108 Institute of Clinical Medical and Pharmaceutical Sciences, Hanoi, Viet Nam; Vietnamese-German Center for Medical Research (VG-CARE), Hanoi, Viet Nam.
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Źródło :
Gene [Gene] 2022 Jan 05; Vol. 806, pp. 145935. Date of Electronic Publication: 2021 Aug 31.
Typ publikacji :
Journal Article
MeSH Terms :
Polymorphism, Genetic*
B7-H1 Antigen/*genetics
Carcinoma, Hepatocellular/*genetics
Hepatitis B virus/*pathogenicity
Hepatitis B, Chronic/*genetics
Liver Cirrhosis/*genetics
Liver Neoplasms/*genetics
3' Untranslated Regions ; Adult ; Aged ; B7-H1 Antigen/blood ; Biomarkers/blood ; Carcinoma, Hepatocellular/diagnosis ; Carcinoma, Hepatocellular/etiology ; Carcinoma, Hepatocellular/virology ; Case-Control Studies ; Disease Progression ; Female ; Gene Expression ; Genetic Predisposition to Disease ; Hepatitis B virus/growth & development ; Hepatitis B, Chronic/complications ; Hepatitis B, Chronic/diagnosis ; Hepatitis B, Chronic/virology ; Humans ; Liver/metabolism ; Liver/pathology ; Liver/virology ; Liver Cirrhosis/diagnosis ; Liver Cirrhosis/etiology ; Liver Cirrhosis/virology ; Liver Neoplasms/diagnosis ; Liver Neoplasms/etiology ; Liver Neoplasms/virology ; Male ; Middle Aged ; Predictive Value of Tests
Czasopismo naukowe
Tytuł :
PAR2 blockade reverses osimertinib resistance in non-small-cell lung cancer cells via attenuating ERK-mediated EMT and PD-L1 expression.
Autorzy :
Jiang Y; Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs, School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan, PR China. Electronic address: .
Zhuo X; Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs, School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan, PR China.
Wu Y; Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs, School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan, PR China.
Fu X; Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs, School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan, PR China.
Mao C; Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs, School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan, PR China. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Molecular cell research [Biochim Biophys Acta Mol Cell Res] 2022 Jan; Vol. 1869 (1), pp. 119144. Date of Electronic Publication: 2021 Sep 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Resistance, Neoplasm*
B7-H1 Antigen/*metabolism
Carcinoma, Non-Small-Cell Lung/*drug therapy
Epithelial-Mesenchymal Transition/*drug effects
Lung Neoplasms/*drug therapy
Receptor, PAR-2/*antagonists & inhibitors
Acrylamides/pharmacology ; Acrylamides/therapeutic use ; Aniline Compounds/pharmacology ; Aniline Compounds/therapeutic use ; Animals ; B7-H1 Antigen/genetics ; Carcinoma, Non-Small-Cell Lung/metabolism ; Cell Line, Tumor ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Humans ; Lipopeptides/pharmacology ; Lipopeptides/therapeutic use ; Lung Neoplasms/metabolism ; Male ; Mice ; Mice, Inbred BALB C ; Receptor, PAR-2/metabolism
Czasopismo naukowe
Tytuł :
Reversing tumor immunosuppressive microenvironment via targeting codelivery of CpG ODNs/PD-L1 peptide antagonists to enhance the immune checkpoint blockade-based anti-tumor effect.
Autorzy :
Zhang M; Department of Biopharmacy, Shanghai Ocean University, Hucheng Ring Road, Shanghai 201306, China.
Fang Z; Department of Biopharmacy, Shanghai Ocean University, Hucheng Ring Road, Shanghai 201306, China.
Zhang H; Department of Biopharmacy, Shanghai Ocean University, Hucheng Ring Road, Shanghai 201306, China.
Cui M; Department of Biopharmacy, Shanghai Ocean University, Hucheng Ring Road, Shanghai 201306, China.
Wang M; Department of Biopharmacy, Shanghai Ocean University, Hucheng Ring Road, Shanghai 201306, China; School of biological sciences, University Hong Kong, Pokfulam Road, Hong Kong, 999077, China.
Liu K; Department of Biopharmacy, Shanghai Ocean University, Hucheng Ring Road, Shanghai 201306, China. Electronic address: .
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Źródło :
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences [Eur J Pharm Sci] 2022 Jan 01; Vol. 168, pp. 106044. Date of Electronic Publication: 2021 Oct 16.
Typ publikacji :
Journal Article
MeSH Terms :
B7-H1 Antigen*
Tumor Microenvironment*
Immune Checkpoint Inhibitors ; Mannose Receptor ; Peptides/pharmacology
Czasopismo naukowe
Tytuł :
PD-L1 expression in recurrent head and neck squamous cell carcinoma.
Autorzy :
Delafoy A; Radiation Oncology Department, University Hospital Morvan, 2 avenue Foch, 29200, Brest, France.
Uguen A; Department of Pathology, University Hospital Morvan, 2 avenue Foch, 29200, Brest, France.
Lemasson G; Department of Pathology, University Hospital Morvan, 2 avenue Foch, 29200, Brest, France.
Conan-Charlet V; Department of Pathology, University Hospital Morvan, 2 avenue Foch, 29200, Brest, France.
Pradier O; Radiation Oncology Department, University Hospital Morvan, 2 avenue Foch, 29200, Brest, France.; LaTIM, INSERM, UMR 1101, University of Brest, ISBAM, UBO, UBL, Brest, France.
Lucia F; Radiation Oncology Department, University Hospital Morvan, 2 avenue Foch, 29200, Brest, France. .; LaTIM, INSERM, UMR 1101, University of Brest, ISBAM, UBO, UBL, Brest, France. .
Schick U; Radiation Oncology Department, University Hospital Morvan, 2 avenue Foch, 29200, Brest, France.; LaTIM, INSERM, UMR 1101, University of Brest, ISBAM, UBO, UBL, Brest, France.
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Źródło :
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery [Eur Arch Otorhinolaryngol] 2022 Jan; Vol. 279 (1), pp. 343-351. Date of Electronic Publication: 2021 Apr 01.
Typ publikacji :
Journal Article
MeSH Terms :
B7-H1 Antigen*/metabolism
Head and Neck Neoplasms/*metabolism
Squamous Cell Carcinoma of Head and Neck/*metabolism
Head and Neck Neoplasms/therapy ; Humans ; Prognosis ; Recurrence ; Squamous Cell Carcinoma of Head and Neck/therapy
Czasopismo naukowe
Tytuł :
PD-L1 Triggered by Binding eIF3I Contributes to the Amelioration of Diabetes-Associated Wound Healing Defects by Regulating IRS4.
Autorzy :
Kuai L; Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China; Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China.
Xiang YW; Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China; School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Chen QL; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China; Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China.
Ru Y; Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China; Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China.
Yin SY; Center for Translational Medicine, Huaihe Hospital of Henan University, Kaifeng, China.
Li W; Center for Translational Medicine, Huaihe Hospital of Henan University, Kaifeng, China.
Jiang JS; Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China; Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China.
Luo Y; Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China; Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China.
Song JK; Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China; Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China.
Lu B; Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China; School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Luo Y; Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China; Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China.
Li B; Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China; Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China. Electronic address: .
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Źródło :
The Journal of investigative dermatology [J Invest Dermatol] 2022 Jan; Vol. 142 (1), pp. 220-231.e8. Date of Electronic Publication: 2021 Jul 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
B7-H1 Antigen/*metabolism
Diabetes Mellitus, Type 1/*metabolism
Eukaryotic Initiation Factors/*metabolism
Insulin Receptor Substrate Proteins/*metabolism
Intracellular Signaling Peptides and Proteins/*metabolism
Keratinocytes/*physiology
Ulcer/*metabolism
Animals ; B7-H1 Antigen/genetics ; Cell Line ; Disease Models, Animal ; Gene Expression Regulation ; Humans ; Insulin Receptor Substrate Proteins/genetics ; Male ; Mice ; Mice, Inbred C57BL ; Molecular Targeted Therapy ; Protein Binding ; Re-Epithelialization ; Signal Transduction ; Wound Healing
Czasopismo naukowe
Tytuł :
Differential Involvement of Programmed Cell Death Ligands in Skin Immune Responses.
Autorzy :
Tanaka R; Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Ichimura Y; Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Kubota N; Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Saito A; Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Nakamura Y; Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Ishitsuka Y; Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan; Laboratory of Cutaneous Immunology, WPI Immunology Frontier Research Center, Osaka University, Suita, Japan.
Watanabe R; Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan; Laboratory of Cutaneous Immunology, WPI Immunology Frontier Research Center, Osaka University, Suita, Japan.
Fujisawa Y; Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Mizuno S; Laboratory Animal Resource Center, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Takahashi S; Laboratory Animal Resource Center, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Fujimoto M; Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan; Department of Dermatology, Graduate School of Medicine, Faculty of Medicine, Osaka University, Suita, Japan.
Okiyama N; Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan. Electronic address: .
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Źródło :
The Journal of investigative dermatology [J Invest Dermatol] 2022 Jan; Vol. 142 (1), pp. 145-154.e8. Date of Electronic Publication: 2021 Jul 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
B7-H1 Antigen/*metabolism
Dendritic Cells/*immunology
Dermatitis, Atopic/*immunology
Dermatitis, Contact/*immunology
Inflammation/*immunology
Macrophages/*immunology
Programmed Cell Death 1 Ligand 2 Protein/*metabolism
Psoriasis/*immunology
Skin/*pathology
Th1 Cells/*immunology
Th17 Cells/*immunology
Th2 Cells/*immunology
Animals ; Antigen Presentation ; B7-H1 Antigen/genetics ; Calcitriol/analogs & derivatives ; Cells, Cultured ; Cytokines/metabolism ; Dinitrofluorobenzene ; Disease Models, Animal ; Humans ; Imiquimod ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Programmed Cell Death 1 Ligand 2 Protein/genetics ; Skin/immunology
Czasopismo naukowe
Tytuł :
A CT-based radiomics signature for preoperative discrimination between high and low expression of programmed death ligand 1 in head and neck squamous cell carcinoma.
Autorzy :
Zheng YM; Health Management Center, The Affiliated Hospital of Qingdao University, Qingdao, China.
Zhan JF; Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Yuan MG; Department of Nuclear Medicine, Affiliated Qingdao Central Hospital, Qingdao University, Qingdao, China.
Hou F; Department of Pathology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Jiang G; Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Wu ZJ; Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Dong C; Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao, China. Electronic address: .
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Źródło :
European journal of radiology [Eur J Radiol] 2022 Jan; Vol. 146, pp. 110093. Date of Electronic Publication: 2021 Dec 04.
Typ publikacji :
Journal Article
MeSH Terms :
B7-H1 Antigen*
Head and Neck Neoplasms*/diagnostic imaging
Humans ; Immunotherapy ; Retrospective Studies ; Squamous Cell Carcinoma of Head and Neck/diagnostic imaging ; Tomography, X-Ray Computed
Czasopismo naukowe
Tytuł :
Extracellular acidity in tumor tissue upregulates programmed cell death protein 1 expression on tumor cells via proton-sensing G protein-coupled receptors.
Autorzy :
Mori D; Department of Immunology, Kyoto Prefectural University of Medicine, Kyoto, Japan.; Department of Otolaryngology-Head and Neck Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Tsujikawa T; Department of Otolaryngology-Head and Neck Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Sugiyama Y; Department of Otolaryngology-Head and Neck Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Kotani SI; Department of Immunology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Fuse S; Department of Otolaryngology-Head and Neck Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Ohmura G; Department of Otolaryngology-Head and Neck Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Arai A; Department of Otolaryngology-Head and Neck Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Kawaguchi T; Department of Digestive Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Hirano S; Department of Otolaryngology-Head and Neck Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Mazda O; Department of Immunology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Kishida T; Department of Immunology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
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Źródło :
International journal of cancer [Int J Cancer] 2021 Dec 15; Vol. 149 (12), pp. 2116-2124. Date of Electronic Publication: 2021 Sep 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
B7-H1 Antigen/*genetics
Neoplasms/*immunology
Receptors, G-Protein-Coupled/*metabolism
Animals ; B7-H1 Antigen/metabolism ; Cell Line, Tumor/transplantation ; Datasets as Topic ; Disease Models, Animal ; Female ; Gene Expression Regulation, Neoplastic/immunology ; Humans ; Hydrogen-Ion Concentration ; Mice ; Neoplasms/genetics ; Neoplasms/pathology ; Protons ; RNA-Seq ; Tumor Escape/genetics ; Tumor Microenvironment/genetics ; Tumor Microenvironment/immunology ; Up-Regulation
Czasopismo naukowe

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