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Tytuł :
Design, synthesis and evaluation of carbazole derivatives as potential antimicrobial agents.
Autorzy :
Xue YJ; Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, Yanbian University, Yanji, China.; School of Pharmacy, Fudan University, Shanghai, China.
Li MY; Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, Yanbian University, Yanji, China.
Jin XJ; Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, Yanbian University, Yanji, China.
Zheng CJ; Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, Yanbian University, Yanji, China.
Piao HR; Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, Yanbian University, Yanji, China.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 295-306.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Infective Agents/*chemical synthesis
Bacterial Proteins/*chemistry
Carbazoles/*chemical synthesis
Enzyme Inhibitors/*chemical synthesis
Escherichia coli/*drug effects
Tetrahydrofolate Dehydrogenase/*chemistry
Anti-Infective Agents/pharmacology ; Bacterial Proteins/antagonists & inhibitors ; Bacterial Proteins/metabolism ; Binding Sites ; Candida albicans/drug effects ; Candida albicans/enzymology ; Candida albicans/growth & development ; Carbazoles/pharmacology ; Cell Line ; Cell Line, Tumor ; Enzyme Inhibitors/pharmacology ; Epithelial Cells/drug effects ; Escherichia coli/enzymology ; Escherichia coli/growth & development ; Guanidines/chemistry ; Hepatocytes/drug effects ; Humans ; Inhibitory Concentration 50 ; Isonicotinic Acids/chemistry ; Methicillin-Resistant Staphylococcus aureus/drug effects ; Methicillin-Resistant Staphylococcus aureus/enzymology ; Methicillin-Resistant Staphylococcus aureus/growth & development ; Microbial Sensitivity Tests ; Molecular Docking Simulation ; Protein Binding ; Protein Conformation ; Protein Interaction Domains and Motifs ; Semicarbazides/chemistry ; Staphylococcus aureus/drug effects ; Staphylococcus aureus/enzymology ; Staphylococcus aureus/growth & development ; Streptococcus mutans/drug effects ; Streptococcus mutans/enzymology ; Streptococcus mutans/growth & development ; Structure-Activity Relationship ; Tetrahydrofolate Dehydrogenase/metabolism ; Triazines/chemistry
Czasopismo naukowe
Tytuł :
Increasing chitosanase production in Bacillus cereus by a novel mutagenesis and screen method.
Autorzy :
Zhang C; Key Laboratory of Ministry of Education Industrial Fermentation Microbiology, Tianjin Key Laboratory of Industrial Microbiology, Tianjin Engineering Research Center of Microbial Metabolism and Fermentation Process Control, College of Biotechnology, Tianjin University of Science and Technology , Tianjin, P. R. China.
Li Y; Key Laboratory of Ministry of Education Industrial Fermentation Microbiology, Tianjin Key Laboratory of Industrial Microbiology, Tianjin Engineering Research Center of Microbial Metabolism and Fermentation Process Control, College of Biotechnology, Tianjin University of Science and Technology , Tianjin, P. R. China.
Zhang T; Key Laboratory of Ministry of Education Industrial Fermentation Microbiology, Tianjin Key Laboratory of Industrial Microbiology, Tianjin Engineering Research Center of Microbial Metabolism and Fermentation Process Control, College of Biotechnology, Tianjin University of Science and Technology , Tianjin, P. R. China.
Zhao H; Key Laboratory of Ministry of Education Industrial Fermentation Microbiology, Tianjin Key Laboratory of Industrial Microbiology, Tianjin Engineering Research Center of Microbial Metabolism and Fermentation Process Control, College of Biotechnology, Tianjin University of Science and Technology , Tianjin, P. R. China.
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Źródło :
Bioengineered [Bioengineered] 2021 Dec; Vol. 12 (1), pp. 266-277.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bacillus cereus*/enzymology
Bacillus cereus*/genetics
Bacterial Proteins*/chemistry
Bacterial Proteins*/genetics
Bacterial Proteins*/metabolism
Glycoside Hydrolases*/chemistry
Glycoside Hydrolases*/genetics
Glycoside Hydrolases*/metabolism
Mutagenesis/*genetics
Culture Media ; Enzyme Stability ; Fermentation ; Protein Engineering ; Soil Microbiology
Czasopismo naukowe
Tytuł :
Pathogenicity and virulence of Streptococcus pneumoniae : Cutting to the chase on proteases.
Autorzy :
Marquart ME; Department of Microbiology and Immunology, University of Mississippi Medical Center, Jackson, Mississippi USA.
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Źródło :
Virulence [Virulence] 2021 Dec; Vol. 12 (1), pp. 766-787.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Bacterial Proteins/*genetics
Peptide Hydrolases/*metabolism
Streptococcus pneumoniae/*enzymology
Streptococcus pneumoniae/*immunology
Streptococcus pneumoniae/*pathogenicity
Animals ; Bacterial Proteins/immunology ; Bacterial Proteins/metabolism ; Genome, Bacterial ; Humans ; Immune Evasion ; Lung/microbiology ; Mice ; Nasopharynx/microbiology ; Peptide Hydrolases/genetics ; Virulence ; Virulence Factors
Czasopismo naukowe
Tytuł :
Development of novel isatin-nicotinohydrazide hybrids with potent activity against susceptible/resistant Mycobacterium tuberculosis and bronchitis causing-bacteria.
Autorzy :
Elsayed ZM; Faculty of Pharmacy, Scientific Research and Innovation Support Unit, Kafrelsheikh University, Kafrelsheikh, Egypt.
Eldehna WM; Faculty of Pharmacy, Scientific Research and Innovation Support Unit, Kafrelsheikh University, Kafrelsheikh, Egypt.; Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Kafrelsheikh University, Kafrelsheikh, Egypt.
Abdel-Aziz MM; The Regional Center for Mycology & Biotechnology, Al-Azhar University, Cairo, Egypt.
El Hassab MA; Department of Pharmaceutical Chemistry, School of Pharmacy, Badr University in Cairo, Badr City, Egypt.
Elkaeed EB; Department of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University, Ad Diriyah, Saudi Arabia.; Faculty of Pharmacy (Boys), Department of Pharmaceutical Organic Chemistry, Al-Azhar University, Cairo, Egypt.
Al-Warhi T; Department of Chemistry, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.
Abdel-Aziz HA; Department of Applied Organic Chemistry, National Research Center, Giza, Egypt.
Abou-Seri SM; Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Cairo University, Cairo, Egypt.
Mohammed ER; Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Cairo University, Cairo, Egypt.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 384-393.
Typ publikacji :
Journal Article
MeSH Terms :
Alcohol Oxidoreductases/*antagonists & inhibitors
Anti-Bacterial Agents/*chemical synthesis
Bacterial Proteins/*antagonists & inhibitors
Drug Resistance, Bacterial/*drug effects
Hydrazines/*chemistry
Isatin/*chemistry
Mycobacterium tuberculosis/*enzymology
Alcohol Oxidoreductases/chemistry ; Alcohol Oxidoreductases/metabolism ; Anti-Bacterial Agents/pharmacology ; Bacterial Proteins/chemistry ; Bacterial Proteins/metabolism ; Binding Sites ; Bordetella pertussis/chemistry ; Bordetella pertussis/enzymology ; Bordetella pertussis/isolation & purification ; Bronchitis/drug therapy ; Bronchitis/microbiology ; Drug Design ; Drug Resistance, Bacterial/genetics ; Haemophilus influenzae/chemistry ; Haemophilus influenzae/enzymology ; Haemophilus influenzae/isolation & purification ; Isoniazid/pharmacology ; Klebsiella pneumoniae/chemistry ; Klebsiella pneumoniae/enzymology ; Klebsiella pneumoniae/isolation & purification ; Microbial Sensitivity Tests ; Molecular Docking Simulation ; Moraxella catarrhalis/chemistry ; Moraxella catarrhalis/enzymology ; Moraxella catarrhalis/isolation & purification ; Mycobacterium tuberculosis/chemistry ; Mycobacterium tuberculosis/isolation & purification ; Protein Binding ; Protein Conformation ; Protein Interaction Domains and Motifs ; Streptococcus pneumoniae/chemistry ; Streptococcus pneumoniae/enzymology ; Streptococcus pneumoniae/isolation & purification ; Streptomycin/pharmacology ; Structure-Activity Relationship ; Tuberculosis/drug therapy ; Tuberculosis/microbiology
Czasopismo naukowe
Tytuł :
Anion inhibition studies of the Zn(II)-bound ι-carbonic anhydrase from the Gram-negative bacterium Burkholderia territorii .
Autorzy :
Petreni A; Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Polo Scientifico, Firenze, Italy.
De Luca V; Department of Biology, Agriculture and Food Sciences, CNR, Institute of Biosciences and Bioresources, Napoli, Italy.; Proteomics and Mass Spectrometry Laboratory, ISPAAM, CNR, Naples, Italy.
Scaloni A; Proteomics and Mass Spectrometry Laboratory, ISPAAM, CNR, Naples, Italy.
Nocentini A; Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Polo Scientifico, Firenze, Italy.
Capasso C; Department of Biology, Agriculture and Food Sciences, CNR, Institute of Biosciences and Bioresources, Napoli, Italy.
Supuran CT; Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Polo Scientifico, Firenze, Italy.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 372-376.
Typ publikacji :
Journal Article
MeSH Terms :
Anions/*pharmacology
Bacterial Proteins/*antagonists & inhibitors
Burkholderia/*enzymology
Carbonic Anhydrases/*metabolism
Small Molecule Libraries/*pharmacology
Arsenicals/pharmacology ; Bacterial Proteins/chemistry ; Bacterial Proteins/metabolism ; Boronic Acids/pharmacology ; Burkholderia/chemistry ; Carbon Dioxide/chemistry ; Carbon Dioxide/metabolism ; Carbonic Anhydrases/chemistry ; Recombinant Proteins/chemistry ; Recombinant Proteins/metabolism ; Sulfonamides/pharmacology ; Sulfonic Acids/pharmacology ; Tin Compounds/pharmacology ; Zinc/chemistry ; Zinc/metabolism
SCR Organism :
Burkholderia territorii
Czasopismo naukowe
Tytuł :
Distinct allosteric mechanisms of first-generation MsbA inhibitors.
Autorzy :
Thélot FA; Department of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Biological and Biomedical Sciences Program, Harvard University, Cambridge, MA, USA.
Zhang W; Key Laboratory of Structural Biology of Zhejiang Province, Westlake University, Hangzhou, China.; Westlake AI Therapeutics Lab, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China.
Song K; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA, USA.; Cryo-EM Core Facility, University of Massachusetts Medical School, Worcester, MA, USA.
Xu C; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA, USA.; Cryo-EM Core Facility, University of Massachusetts Medical School, Worcester, MA, USA.
Huang J; Key Laboratory of Structural Biology of Zhejiang Province, Westlake University, Hangzhou, China.; Westlake AI Therapeutics Lab, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China.
Liao M; Department of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
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Źródło :
Science (New York, N.Y.) [Science] 2021 Oct 29; Vol. 374 (6567), pp. 580-585. Date of Electronic Publication: 2021 Sep 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
ATP-Binding Cassette Transporters/*antagonists & inhibitors
ATP-Binding Cassette Transporters/*metabolism
Bacterial Proteins/*antagonists & inhibitors
Bacterial Proteins/*metabolism
ATP-Binding Cassette Transporters/chemistry ; Adenosine Triphosphatases/metabolism ; Allosteric Regulation ; Bacterial Proteins/chemistry ; Binding Sites ; Cryoelectron Microscopy ; Drug Discovery ; Imaging, Three-Dimensional ; Lipopolysaccharides/metabolism ; Models, Molecular ; Molecular Dynamics Simulation ; Protein Binding ; Protein Conformation ; Small Molecule Libraries
Czasopismo naukowe
Tytuł :
Cryo-EM structure of the monomeric Rhodobacter sphaeroides RC-LH1 core complex at 2.5 Å.
Autorzy :
Qian P; Materials and Structural Analysis, Thermo Fisher Scientific, Achtseweg Noord 5, 5651 GG Eindhoven, Netherlands.; Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, U.K.
Swainsbury DJK; Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, U.K.
Croll TI; Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, U.K.
Salisbury JH; Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, U.K.
Martin EC; Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, U.K.
Jackson PJ; Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, U.K.; Department of Chemical and Biological Engineering, University of Sheffield, Sheffield, U.K.
Hitchcock A; Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, U.K.
Castro-Hartmann P; Materials and Structural Analysis, Thermo Fisher Scientific, Achtseweg Noord 5, 5651 GG Eindhoven, Netherlands.
Sader K; Materials and Structural Analysis, Thermo Fisher Scientific, Achtseweg Noord 5, 5651 GG Eindhoven, Netherlands.
Hunter CN; Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, U.K.
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Źródło :
The Biochemical journal [Biochem J] 2021 Oct 29; Vol. 478 (20), pp. 3775-3790.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bacterial Proteins/*chemistry
Light-Harvesting Protein Complexes/*chemistry
Peptides/*chemistry
Photosynthesis/*physiology
Photosynthetic Reaction Center Complex Proteins/*chemistry
Rhodobacter sphaeroides/*chemistry
Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Bacteriochlorophylls/chemistry ; Bacteriochlorophylls/metabolism ; Binding Sites ; Carotenoids/chemistry ; Carotenoids/metabolism ; Cryoelectron Microscopy ; Gene Expression ; Hydroquinones/chemistry ; Hydroquinones/metabolism ; Light ; Light-Harvesting Protein Complexes/genetics ; Light-Harvesting Protein Complexes/metabolism ; Models, Molecular ; Peptides/genetics ; Peptides/metabolism ; Photosynthetic Reaction Center Complex Proteins/genetics ; Photosynthetic Reaction Center Complex Proteins/metabolism ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Interaction Domains and Motifs ; Protein Multimerization ; Protein Subunits/chemistry ; Protein Subunits/genetics ; Protein Subunits/metabolism ; Rhodobacter sphaeroides/genetics ; Rhodobacter sphaeroides/metabolism ; Rhodobacter sphaeroides/radiation effects
Czasopismo naukowe
Tytuł :
A Promiscuous Halogenase for the Derivatization of Flavonoids.
Autorzy :
Kolling D; Department of Pharmaceutical Biotechnology, Saarland University, 66123 Saarbruecken, Germany.
Stierhof M; Department of Pharmaceutical Biotechnology, Saarland University, 66123 Saarbruecken, Germany.
Lasch C; Department of Pharmaceutical Biotechnology, Saarland University, 66123 Saarbruecken, Germany.
Myronovskyi M; Department of Pharmaceutical Biotechnology, Saarland University, 66123 Saarbruecken, Germany.
Luzhetskyy A; Department of Pharmaceutical Biotechnology, Saarland University, 66123 Saarbruecken, Germany.; AMEG Department, Helmholtz Institute for Pharmaceutical Research Saarland, 66123 Saarbruecken, Germany.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Oct 14; Vol. 26 (20). Date of Electronic Publication: 2021 Oct 14.
Typ publikacji :
Journal Article
MeSH Terms :
Halogenation*
Bacterial Proteins/*metabolism
Flavonoids/*metabolism
Oxidoreductases/*metabolism
Bacterial Proteins/chemistry ; Bacterial Proteins/genetics ; Biocatalysis ; Drug Discovery ; Flavonoids/chemistry ; Frankia/enzymology ; Frankia/genetics ; Genes, Bacterial ; Molecular Docking Simulation ; Oxidoreductases/chemistry ; Oxidoreductases/genetics ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Substrate Specificity
SCR Organism :
Frankia alni
Czasopismo naukowe
Tytuł :
Secondary-structure switch regulates the substrate binding of a YopJ family acetyltransferase.
Autorzy :
Xia Y; International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), College of Pharmacy, Jinan University, 510632, Guangzhou, China.; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, 510632, Guangzhou, China.
Zou R; Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, 518005, Shenzhen, China.
Escouboué M; Laboratoire des Interactions Plantes-Microbes-Environnement (LIPME), INRAE, CNRS, Université de Toulouse, 31326, Castanet-Tolosan, France.
Zhong L; International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), College of Pharmacy, Jinan University, 510632, Guangzhou, China.; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, 510632, Guangzhou, China.
Zhu C; International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), College of Pharmacy, Jinan University, 510632, Guangzhou, China.; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, 510632, Guangzhou, China.
Pouzet C; FRAIB-TRI Imaging Platform Facilities, FR AIB, Université de Toulouse, CNRS, 31320, Castanet-Tolosan, France.
Wu X; Institute for Pharmaceutical Analysis, College of Pharmacy, Jinan University, 510632, Guangzhou, China.
Wang Y; International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), College of Pharmacy, Jinan University, 510632, Guangzhou, China.; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, 510632, Guangzhou, China.
Lv G; Division of Histology & Embryology, Medical College, Jinan University, 510632, Guangzhou, China.
Zhou H; Institute for Pharmaceutical Analysis, College of Pharmacy, Jinan University, 510632, Guangzhou, China.
Sun P; International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), College of Pharmacy, Jinan University, 510632, Guangzhou, China. .; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, 510632, Guangzhou, China. .
Ding K; International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), College of Pharmacy, Jinan University, 510632, Guangzhou, China. .; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, 510632, Guangzhou, China. .
Deslandes L; Laboratoire des Interactions Plantes-Microbes-Environnement (LIPME), INRAE, CNRS, Université de Toulouse, 31326, Castanet-Tolosan, France. .
Yuan S; Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, 518005, Shenzhen, China. .
Zhang ZM; International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), College of Pharmacy, Jinan University, 510632, Guangzhou, China. .; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, 510632, Guangzhou, China. .
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Źródło :
Nature communications [Nat Commun] 2021 Oct 13; Vol. 12 (1), pp. 5969. Date of Electronic Publication: 2021 Oct 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Acetyltransferases/*chemistry
Apoproteins/*chemistry
Arabidopsis/*microbiology
Bacterial Proteins/*chemistry
Phytic Acid/*chemistry
Ralstonia solanacearum/*chemistry
Acetyltransferases/genetics ; Acetyltransferases/metabolism ; Allosteric Regulation ; Apoproteins/genetics ; Apoproteins/metabolism ; Arabidopsis Proteins/chemistry ; Arabidopsis Proteins/genetics ; Arabidopsis Proteins/metabolism ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Catalytic Domain ; Cloning, Molecular ; Crystallography, X-Ray ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Gene Expression ; Genetic Vectors/chemistry ; Genetic Vectors/metabolism ; Models, Molecular ; Phytic Acid/metabolism ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Interaction Domains and Motifs ; Ralstonia solanacearum/enzymology ; Recombinant Fusion Proteins/chemistry ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/metabolism ; Substrate Specificity ; Tobacco/microbiology
Czasopismo naukowe
Tytuł :
Reconstitution of an intact clock reveals mechanisms of circadian timekeeping.
Autorzy :
Chavan AG; School of Natural Sciences, University of California, Merced, CA 95343, USA.
Swan JA; Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA.
Heisler J; Department of Chemistry and Biochemistry, University of California, Merced, CA 95343, USA.
Sancar C; Center for Circadian Biology, University of California, San Diego, La Jolla, CA 92093, USA.
Ernst DC; Center for Circadian Biology, University of California, San Diego, La Jolla, CA 92093, USA.
Fang M; Center for Circadian Biology, University of California, San Diego, La Jolla, CA 92093, USA.
Palacios JG; Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA.
Spangler RK; Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA.
Bagshaw CR; Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA.
Tripathi S; Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA.
Crosby P; Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA.
Golden SS; Center for Circadian Biology, University of California, San Diego, La Jolla, CA 92093, USA.; Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
Partch CL; Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA.; Center for Circadian Biology, University of California, San Diego, La Jolla, CA 92093, USA.
LiWang A; School of Natural Sciences, University of California, Merced, CA 95343, USA.; Department of Chemistry and Biochemistry, University of California, Merced, CA 95343, USA.; Center for Circadian Biology, University of California, San Diego, La Jolla, CA 92093, USA.; Center for Cellular and Biomolecular Machines, University of California, Merced, CA 95343, USA.; Health Sciences Research Institute, University of California, Merced, CA 95343, USA.
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Źródło :
Science (New York, N.Y.) [Science] 2021 Oct 08; Vol. 374 (6564), pp. eabd4453. Date of Electronic Publication: 2021 Oct 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Bacterial Proteins/*metabolism
Circadian Rhythm/*physiology
Circadian Rhythm Signaling Peptides and Proteins/*metabolism
Phosphotransferases/*metabolism
Synechococcus/*physiology
Bacterial Proteins/chemistry ; Bacterial Proteins/genetics ; Circadian Rhythm/genetics ; Circadian Rhythm Signaling Peptides and Proteins/chemistry ; Circadian Rhythm Signaling Peptides and Proteins/genetics ; Gene Expression Regulation, Bacterial ; Molecular Mimicry ; Mutation ; Phosphotransferases/chemistry ; Phosphotransferases/genetics ; Promoter Regions, Genetic ; Protein Domains ; Protein Folding ; Protein Kinases/metabolism ; Protein Multimerization ; Synechococcus/genetics ; Synechococcus/metabolism ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
Characterization of the Chimeric PriB-SSBc Protein.
Autorzy :
Lin ES; Department of Beauty Science, National Taichung University of Science and Technology, No. 193, Sec.1, San-Min Rd., Taichung City 403, Taiwan.
Huang YH; School of Biomedical Sciences, Chung Shan Medical University, No. 110, Sec.1, Chien-Kuo N. Rd., Taichung City 402, Taiwan.
Huang CY; School of Biomedical Sciences, Chung Shan Medical University, No. 110, Sec.1, Chien-Kuo N. Rd., Taichung City 402, Taiwan.; Department of Medical Research, Chung Shan Medical University Hospital, No. 110, Sec.1, Chien-Kuo N. Rd., Taichung City 402, Taiwan.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Oct 07; Vol. 22 (19). Date of Electronic Publication: 2021 Oct 07.
Typ publikacji :
Journal Article
MeSH Terms :
Bacterial Proteins/*chemistry
Bacterial Proteins/*metabolism
Klebsiella pneumoniae/*metabolism
Recombinant Fusion Proteins/*chemistry
Recombinant Fusion Proteins/*metabolism
Amino Acid Sequence ; Bacterial Proteins/genetics ; Crystallography, X-Ray ; DNA Replication ; DNA-Binding Proteins/chemistry ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Models, Molecular ; Protein Conformation ; Protein Interaction Domains and Motifs ; Recombinant Fusion Proteins/genetics ; Sequence Homology
Czasopismo naukowe
Tytuł :
Residual Helicity at the Active Site of the Histidine Phosphocarrier, HPr, Modulates Binding Affinity to Its Natural Partners.
Autorzy :
Neira JL; IDIBE, Universidad Miguel Hernández, 03202 Elche, Spain.; Joint Units IQFR-CSIC-BIFI, and GBsC-CSIC-BIFI, Instituto de Biocomputación y Física de Sistemas Complejos (BIFI), Universidad de Zaragoza, 50018 Zaragoza, Spain.
Ortega-Alarcón D; Joint Units IQFR-CSIC-BIFI, and GBsC-CSIC-BIFI, Instituto de Biocomputación y Física de Sistemas Complejos (BIFI), Universidad de Zaragoza, 50018 Zaragoza, Spain.; Departamento de Bioquímica y Biología Molecular y Celular, Universidad de Zaragoza, 50009 Zaragoza, Spain.
Rizzuti B; Joint Units IQFR-CSIC-BIFI, and GBsC-CSIC-BIFI, Instituto de Biocomputación y Física de Sistemas Complejos (BIFI), Universidad de Zaragoza, 50018 Zaragoza, Spain.; CNR-NANOTEC, SS Rende (CS), Department of Physics, University of Calabria, Via P. Bucci, Cubo 31 C, 87036 Rende, Italy.
Palomino-Schätzlein M; Centro de Investigación Príncipe Felipe, Calle Eduardo Primo Yufera 3, 46022 Valencia, Spain.
Velázquez-Campoy A; Joint Units IQFR-CSIC-BIFI, and GBsC-CSIC-BIFI, Instituto de Biocomputación y Física de Sistemas Complejos (BIFI), Universidad de Zaragoza, 50018 Zaragoza, Spain.; Departamento de Bioquímica y Biología Molecular y Celular, Universidad de Zaragoza, 50009 Zaragoza, Spain.; Instituto de Investigación Sanitaria Aragón (IIS Aragón), 50009 Zaragoza, Spain.; Centro de Investigación Biomédica en Red en el Área Temática de Enfermedades Hepáticas y Digestivas (CIBERehd), 28029 Madrid, Spain.; Fundacion ARAID, Government of Aragon, 50009 Zaragoza, Spain.
Falcó A; IDIBE, Universidad Miguel Hernández, 03202 Elche, Spain.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Oct 06; Vol. 22 (19). Date of Electronic Publication: 2021 Oct 06.
Typ publikacji :
Journal Article
MeSH Terms :
Mutation*
Anti-Bacterial Agents/*pharmacology
Bacterial Proteins/*metabolism
Histidine/*metabolism
Peptide Fragments/*pharmacology
Phosphoenolpyruvate Sugar Phosphotransferase System/*metabolism
Staphylococcus aureus/*drug effects
Anti-Bacterial Agents/chemistry ; Bacterial Proteins/chemistry ; Bacterial Proteins/genetics ; Binding Sites ; Catalytic Domain ; Histidine/chemistry ; Peptide Fragments/chemistry ; Phosphoenolpyruvate Sugar Phosphotransferase System/chemistry ; Phosphoenolpyruvate Sugar Phosphotransferase System/genetics ; Staphylococcus aureus/metabolism
Czasopismo naukowe
Tytuł :
Proline-Glutamate/Proline-Proline-Glutamate (PE/PPE) proteins of Mycobacterium tuberculosis: The multifaceted immune-modulators.
Autorzy :
Medha; DS Kothari Central Interdisciplinary Research Centre and Department of Zoology, Miranda House, University of Delhi, Delhi 110007, India. Electronic address: .
Sharma S; DS Kothari Central Interdisciplinary Research Centre and Department of Zoology, Miranda House, University of Delhi, Delhi 110007, India. Electronic address: .
Sharma M; DS Kothari Central Interdisciplinary Research Centre and Department of Zoology, Miranda House, University of Delhi, Delhi 110007, India. Electronic address: .
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Źródło :
Acta tropica [Acta Trop] 2021 Oct; Vol. 222, pp. 106035. Date of Electronic Publication: 2021 Jul 03.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Bacterial Proteins*/genetics
Bacterial Proteins*/immunology
Mycobacterium tuberculosis*/genetics
Mycobacterium tuberculosis*/immunology
Antigens, Bacterial/genetics ; Antigens, Bacterial/immunology ; Glutamic Acid ; Humans ; Proline ; Tuberculosis
Czasopismo naukowe
Tytuł :
Activity of β-lactam plus β-lactam-enhancer combination cefepime/zidebactam against Klebsiella pneumoniae harbouring defective OmpK35/36 porins and carbapenemases.
Autorzy :
Joshi P; Drug Discovery Research, Wockhardt Research Center, Aurangabad, Maharashtra, India.
Shrivastava R; Drug Discovery Research, Wockhardt Research Center, Aurangabad, Maharashtra, India.
Bhagwat S; Drug Discovery Research, Wockhardt Research Center, Aurangabad, Maharashtra, India. Electronic address: .
Patel M; Drug Discovery Research, Wockhardt Research Center, Aurangabad, Maharashtra, India.
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Źródło :
Diagnostic microbiology and infectious disease [Diagn Microbiol Infect Dis] 2021 Oct; Vol. 101 (2), pp. 115481. Date of Electronic Publication: 2021 Jul 09.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Bacterial Agents/*pharmacology
Bacterial Proteins/*antagonists & inhibitors
Bacterial Proteins/*genetics
Klebsiella Infections/*drug therapy
Klebsiella pneumoniae/*enzymology
Porins/*genetics
Azabicyclo Compounds/pharmacology ; Bacterial Proteins/metabolism ; Carbapenems/pharmacology ; Cephalosporins/pharmacology ; Cyclooctanes/pharmacology ; Drug Resistance, Multiple, Bacterial ; Humans ; Klebsiella Infections/microbiology ; Klebsiella pneumoniae/drug effects ; Klebsiella pneumoniae/genetics ; Microbial Sensitivity Tests ; Mutation ; Porins/metabolism ; beta-Lactamases/genetics ; beta-Lactamases/metabolism ; beta-Lactams/pharmacology
Czasopismo naukowe
Tytuł :
Structural and DNA-binding properties of the cytoplasmic domain of Vibrio cholerae transcription factor ToxR.
Autorzy :
Gubensäk N; Institute of Chemistry/Organic and Bioorganic Chemistry, University of Graz, Graz, Austria; Institute of Molecular Biosciences, University of Graz, Graz, Austria. Electronic address: .
Schrank E; Institute of Chemistry/Organic and Bioorganic Chemistry, University of Graz, Graz, Austria.
Hartlmüller C; Center for Integrated Protein Science Munich (CIPSM) at the Department of Chemistry, Technische Universität München, Garching, Germany.
Göbl C; Department of Pathology and Biomedical Science, University of Otago Christchurch, Christchurch, New Zealand.
Falsone FS; Institute of Chemistry/Organic and Bioorganic Chemistry, University of Graz, Graz, Austria; Institute of Pharmaceutical Sciences/Pharmaceutical Technology and Biopharmacy, University of Graz, Graz, Austria.
Becker W; Institute of Chemistry/Organic and Bioorganic Chemistry, University of Graz, Graz, Austria; Department of Medical Biochemistry and Biophysics, Karolinska Institute, Solna, Sweden.
Wagner GE; Institute of Chemistry/Organic and Bioorganic Chemistry, University of Graz, Graz, Austria; Diagnostic and Research Institute of Hygiene, Microbiology and Environmental Medicine, Medical University of Graz, Graz, Austria.
Pulido S; Institute of Chemistry/Organic and Bioorganic Chemistry, University of Graz, Graz, Austria.
Meyer NH; Institute of Chemistry/Organic and Bioorganic Chemistry, University of Graz, Graz, Austria; Division of Experimental Allergology and Immunodermatology, University of Oldenburg, Oldenburg, Germany.
Pavkov-Keller T; Institute of Molecular Biosciences, University of Graz, Graz, Austria; BioTechMed-Graz, Graz, Austria; Field of Excellence BioHealth, University of Graz, Graz, Austria.
Madl T; BioTechMed-Graz, Graz, Austria; Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Institute of Molecular Biology & Biochemistry, Medical University of Graz, Graz, Austria.
Reidl J; Institute of Molecular Biosciences, University of Graz, Graz, Austria; BioTechMed-Graz, Graz, Austria; Field of Excellence BioHealth, University of Graz, Graz, Austria.
Zangger K; Institute of Chemistry/Organic and Bioorganic Chemistry, University of Graz, Graz, Austria; BioTechMed-Graz, Graz, Austria; Field of Excellence BioHealth, University of Graz, Graz, Austria. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2021 Oct; Vol. 297 (4), pp. 101167. Date of Electronic Publication: 2021 Sep 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bacterial Proteins/*chemistry
DNA-Binding Proteins/*chemistry
Transcription Factors/*chemistry
Vibrio cholerae/*chemistry
Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Helix-Turn-Helix Motifs ; Protein Domains ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Transcription, Genetic ; Vibrio cholerae/genetics ; Vibrio cholerae/metabolism
Czasopismo naukowe
Tytuł :
The structural mechanism for the nucleoside tri- and diphosphate hydrolysis activity of Ntdp from Staphylococcus aureus.
Autorzy :
Wang Z; National Synchrotron Radiation Laboratory, Hefei National Laboratory for Physical Sciences at Microscale, School of Life Sciences, University of Science and Technology of China, Hefei, China.
Shen H; National Synchrotron Radiation Laboratory, Hefei National Laboratory for Physical Sciences at Microscale, School of Life Sciences, University of Science and Technology of China, Hefei, China.
He B; National Synchrotron Radiation Laboratory, Hefei National Laboratory for Physical Sciences at Microscale, School of Life Sciences, University of Science and Technology of China, Hefei, China.
Teng M; National Synchrotron Radiation Laboratory, Hefei National Laboratory for Physical Sciences at Microscale, School of Life Sciences, University of Science and Technology of China, Hefei, China.
Guo Q; National Synchrotron Radiation Laboratory, Hefei National Laboratory for Physical Sciences at Microscale, School of Life Sciences, University of Science and Technology of China, Hefei, China.
Li X; National Synchrotron Radiation Laboratory, Hefei National Laboratory for Physical Sciences at Microscale, School of Life Sciences, University of Science and Technology of China, Hefei, China.
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Źródło :
The FEBS journal [FEBS J] 2021 Oct; Vol. 288 (20), pp. 6019-6034. Date of Electronic Publication: 2021 Jun 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bacterial Proteins/*metabolism
Diphosphates/*metabolism
Nucleosides/*metabolism
Polyphosphates/*metabolism
Staphylococcus aureus/*physiology
Trans-Activators/*metabolism
Virulence Factors/*metabolism
Bacterial Proteins/chemistry ; Bacterial Proteins/genetics ; Gene Expression Regulation, Bacterial ; Hydrolysis ; Trans-Activators/chemistry ; Trans-Activators/genetics ; Virulence Factors/chemistry ; Virulence Factors/genetics
Czasopismo naukowe
Tytuł :
Computational identification and characterization of antigenic properties of Rv3899c of Mycobacterium tuberculosis and its interaction with human leukocyte antigen (HLA).
Autorzy :
Das R; Department of Life Science, Acharya Narendra Dev College (University of Delhi), Govindpuri, New Delhi, 110019, India.
Eniyan K; Department of Biomedical Science, Acharya Narendra Dev College (University of Delhi), 110019, Govindpuri, New Delhi, India.; Antibiotic Resistance and Phage Therapy Laboratory, School of Bio Sciences and Technology, Vellore Institute of Technology, Vellore, India.
Bajpai U; Department of Biomedical Science, Acharya Narendra Dev College (University of Delhi), 110019, Govindpuri, New Delhi, India. .
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Źródło :
Immunogenetics [Immunogenetics] 2021 Oct; Vol. 73 (5), pp. 357-368. Date of Electronic Publication: 2021 Jul 06.
Typ publikacji :
Journal Article
MeSH Terms :
Bacterial Proteins/*chemistry
Bacterial Proteins/*immunology
HLA-DRB1 Chains/*metabolism
Mycobacterium tuberculosis/*immunology
Amino Acid Motifs ; Bacterial Proteins/metabolism ; Computer Simulation ; Epitopes, B-Lymphocyte/immunology ; HLA-DRB1 Chains/chemistry ; Host-Pathogen Interactions ; Humans ; Immunogenicity, Vaccine ; Molecular Docking Simulation ; Mycobacterium tuberculosis/chemistry ; Protein Domains ; Protein Folding
Czasopismo naukowe
Tytuł :
Discovery of ancestral L-ornithine and L-lysine decarboxylases reveals parallel, pseudoconvergent evolution of polyamine biosynthesis.
Autorzy :
Li B; Department of Biochemistry, UT Southwestern Medical Center, Dallas, Texas, USA.
Liang J; Department of Biochemistry, UT Southwestern Medical Center, Dallas, Texas, USA.
Hanfrey CC; Institute of Food Research, Norwich, United Kingdom.
Phillips MA; Department of Biochemistry, UT Southwestern Medical Center, Dallas, Texas, USA.
Michael AJ; Department of Biochemistry, UT Southwestern Medical Center, Dallas, Texas, USA. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2021 Oct; Vol. 297 (4), pp. 101219. Date of Electronic Publication: 2021 Sep 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Archaeal Proteins*/chemistry
Archaeal Proteins*/genetics
Archaeal Proteins*/metabolism
Bacteria*/enzymology
Bacteria*/genetics
Bacterial Proteins*/chemistry
Bacterial Proteins*/genetics
Bacterial Proteins*/metabolism
Biogenic Polyamines*/biosynthesis
Biogenic Polyamines*/chemistry
Carboxy-Lyases*/chemistry
Carboxy-Lyases*/genetics
Carboxy-Lyases*/metabolism
Euryarchaeota*/enzymology
Euryarchaeota*/genetics
Evolution, Molecular*
Ornithine Decarboxylase*/chemistry
Ornithine Decarboxylase*/genetics
Ornithine Decarboxylase*/metabolism
Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism
Czasopismo naukowe
Tytuł :
Structures and function of the amino acid polymerase cyanophycin synthetase.
Autorzy :
Sharon I; Department of Biochemistry and Centre de Recherche en Biologie Structurale, McGill University, Montréal, Quebec, Canada.
Haque AS; Department of Biochemistry and Centre de Recherche en Biologie Structurale, McGill University, Montréal, Quebec, Canada.
Grogg M; Laboratory of Organic Chemistry, ETH Zürich, Zürich, Switzerland.
Lahiri I; Department of Cellular and Molecular Medicine, and Section of Molecular Biology, Division of Biological Sciences, University of California San Diego (UCSD), La Jolla, CA, USA.
Seebach D; Laboratory of Organic Chemistry, ETH Zürich, Zürich, Switzerland.
Leschziner AE; Department of Cellular and Molecular Medicine, and Section of Molecular Biology, Division of Biological Sciences, University of California San Diego (UCSD), La Jolla, CA, USA.
Hilvert D; Laboratory of Organic Chemistry, ETH Zürich, Zürich, Switzerland.
Schmeing TM; Department of Biochemistry and Centre de Recherche en Biologie Structurale, McGill University, Montréal, Quebec, Canada. .
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Źródło :
Nature chemical biology [Nat Chem Biol] 2021 Oct; Vol. 17 (10), pp. 1101-1110. Date of Electronic Publication: 2021 Aug 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Bacteria/*enzymology
Bacterial Proteins/*chemistry
Bacterial Proteins/*metabolism
Peptide Synthases/*chemistry
Peptide Synthases/*metabolism
Bacteria/genetics ; Bacteria/metabolism ; Bacterial Proteins/genetics ; Gene Expression Regulation, Bacterial ; Gene Expression Regulation, Enzymologic ; Models, Molecular ; Peptide Synthases/genetics ; Protein Conformation
Czasopismo naukowe
Tytuł :
Insights into complex nanopillar-bacteria interactions: Roles of nanotopography and bacterial surface proteins.
Autorzy :
Ishak MI; Bristol Dental School, University of Bristol, Lower Maudlin Street, Bristol BS1 2LY, UK; School of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS, UK; Faculty of Engineering Technology, Universiti Malaysia Perlis (UniMAP), Perlis, Malaysia.
Jenkins J; Bristol Dental School, University of Bristol, Lower Maudlin Street, Bristol BS1 2LY, UK.
Kulkarni S; Deutsches Elektronen-Synchrotron DESY, Notkestraße 85, Hamburg 22607, Germany.
Keller TF; Deutsches Elektronen-Synchrotron DESY, Notkestraße 85, Hamburg 22607, Germany; Physics Department, University of Hamburg, Hamburg, Germany.
Briscoe WH; School of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS, UK.
Nobbs AH; Bristol Dental School, University of Bristol, Lower Maudlin Street, Bristol BS1 2LY, UK.
Su B; Bristol Dental School, University of Bristol, Lower Maudlin Street, Bristol BS1 2LY, UK. Electronic address: .
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Źródło :
Journal of colloid and interface science [J Colloid Interface Sci] 2021 Dec 15; Vol. 604, pp. 91-103. Date of Electronic Publication: 2021 Jul 02.
Typ publikacji :
Journal Article
MeSH Terms :
Bacterial Proteins*
Nanostructures*
Bacteria ; Bacterial Adhesion ; Membrane Proteins ; Surface Properties
Czasopismo naukowe

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