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Tytuł :
Ultrafast Dynamics of a Solvatochromic Dye, Phenol Blue: Tautomerization and Coherent Wavepacket Oscillations.
Autorzy :
Ota C; Department of Applied Chemistry, College of Life Sciences, Ritsumeikan University, Kusatsu, Shiga 525-8577, Japan.
Matsumoto A; Department of Applied Chemistry, College of Life Sciences, Ritsumeikan University, Kusatsu, Shiga 525-8577, Japan.
Hidaka T; Department of Applied Chemistry, College of Life Sciences, Ritsumeikan University, Kusatsu, Shiga 525-8577, Japan.
Sugihara K; Department of Applied Chemistry, College of Life Sciences, Ritsumeikan University, Kusatsu, Shiga 525-8577, Japan.
Teramoto T; Institute for Radiation Sciences, Osaka University, 1-1 Machikaneyama, Toyonaka, Osaka 560-0043, Japan.
Nagasawa Y; Department of Applied Chemistry, College of Life Sciences, Ritsumeikan University, Kusatsu, Shiga 525-8577, Japan.
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Źródło :
The journal of physical chemistry. B [J Phys Chem B] 2021 Sep 30; Vol. 125 (38), pp. 10832-10842. Date of Electronic Publication: 2021 Sep 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Aniline Compounds*
Benzoquinones*
Molecular Structure ; Solutions
Czasopismo naukowe
Tytuł :
Toxic effects of substituted p-benzoquinones and hydroquinones in in vitro bioassays are altered by reactions with the cell assay medium.
Autorzy :
Tentscher PR; Eawag, Swiss Federal Institute of Aquatic Science and Technology, Duebendorf CH-8600, Switzerland; Department of Chemistry and Bioscience, Aalborg University, Aalborg 9220, Denmark.
Escher BI; Department of Cell Toxicology, UFZ - Helmholtz Centre for Environmental Research, Leipzig 04318, Germany; Center for Applied Geoscience, Eberhard Karls University of Tübingen, Schnarrenbergstr. 94-96, Tübingen 72076, Germany.
Schlichting R; Department of Cell Toxicology, UFZ - Helmholtz Centre for Environmental Research, Leipzig 04318, Germany.
König M; Department of Cell Toxicology, UFZ - Helmholtz Centre for Environmental Research, Leipzig 04318, Germany.
Bramaz N; Eawag, Swiss Federal Institute of Aquatic Science and Technology, Duebendorf CH-8600, Switzerland.
Schirmer K; Eawag, Swiss Federal Institute of Aquatic Science and Technology, Duebendorf CH-8600, Switzerland; Department of Environmental Systems Science, ETH Zürich, Zürich CH-8092, Switzerland; Civil and Environmental Engineering (ENAC), School of Architecture, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne CH-1015, Switzerland.
von Gunten U; Eawag, Swiss Federal Institute of Aquatic Science and Technology, Duebendorf CH-8600, Switzerland; Civil and Environmental Engineering (ENAC), School of Architecture, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne CH-1015, Switzerland. Electronic address: .
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Źródło :
Water research [Water Res] 2021 Sep 01; Vol. 202, pp. 117415. Date of Electronic Publication: 2021 Jul 07.
Typ publikacji :
Journal Article
MeSH Terms :
Benzoquinones*/toxicity
Hydroquinones*
Biological Assay ; Oxidation-Reduction ; Phenols ; Quinones
Czasopismo naukowe
Tytuł :
Anticancer activity and toxicity of new quaternary ammonium geldanamycin derivative salts and their mixtures with potentiators.
Autorzy :
Skrzypczak N; Faculty of Chemistry, Adam Mickiewicz University, Poznan, Poland.
Pyta K; Faculty of Chemistry, Adam Mickiewicz University, Poznan, Poland.
Ruszkowski P; Department of Pharmacology, Poznan University of Medical Sciences, Poznan, Poland.
Mikołajczak P; Department of Pharmacology, Poznan University of Medical Sciences, Poznan, Poland.
Kucińska M; Department of Toxicology, Poznan University of Medical Sciences, Poznań, Poland.
Murias M; Department of Toxicology, Poznan University of Medical Sciences, Poznań, Poland.
Gdaniec M; Faculty of Chemistry, Adam Mickiewicz University, Poznan, Poland.
Bartl F; Lebenswissenschaftliche Fakultät, Institutfür Biologie, Biophysikalische Chemie Humboldt-Universität zu Berlin Invalidenstrasse 42, Berlin, Germany.
Przybylski P; Faculty of Chemistry, Adam Mickiewicz University, Poznan, Poland.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 1898-1904.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Benzoquinones/*pharmacology
Lactams, Macrocyclic/*pharmacology
Quaternary Ammonium Compounds/*chemistry
Antineoplastic Agents/chemistry ; Benzoquinones/chemistry ; Cell Line ; Cell Line, Tumor ; Drug Screening Assays, Antitumor ; Drug Synergism ; Humans ; Lactams, Macrocyclic/chemistry ; Molecular Structure ; Salts/chemistry ; Spectrum Analysis/methods
Czasopismo naukowe
Tytuł :
Thymoquinone Loaded Topical Nanoemulgel for Wound Healing: Formulation Design and In-Vivo Evaluation.
Autorzy :
Algahtani MS; Department of Pharmaceutics, College of Pharmacy, Najran University, Najran 11001, Saudi Arabia.
Ahmad MZ; Department of Pharmaceutics, College of Pharmacy, Najran University, Najran 11001, Saudi Arabia.
Shaikh IA; Department of Pharmacology, College of Pharmacy, Najran University, Najran 11001, Saudi Arabia.
Abdel-Wahab BA; Department of Pharmacology, College of Pharmacy, Najran University, Najran 11001, Saudi Arabia.
Nourein IH; Department of Clinical Laboratory (Histopathology and Cytology), College of Applied Medical Sciences, Najran University, Najran 11001, Saudi Arabia.
Ahmad J; Department of Pharmaceutics, College of Pharmacy, Najran University, Najran 11001, Saudi Arabia.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Jun 24; Vol. 26 (13). Date of Electronic Publication: 2021 Jun 24.
Typ publikacji :
Journal Article
MeSH Terms :
Benzoquinones*/chemistry
Benzoquinones*/pharmacokinetics
Benzoquinones*/pharmacology
Drug Delivery Systems*
Nanoparticles*/chemistry
Nanoparticles*/therapeutic use
Skin/*metabolism
Skin Absorption/*drug effects
Wound Healing/*drug effects
Administration, Topical ; Animals ; Emulsions ; Rats ; Rats, Wistar ; Skin/pathology
Czasopismo naukowe
Tytuł :
Impact of zinc oxide nanoparticles and thymoquinone in Ehrlich ascites carcinoma induced in mice.
Autorzy :
Ghanem HB; Clinical Laboratory Sciences Department, College of Applied Medical Sciences, Jouf University, Sakaka, Saudi Arabia.; Medical Biochemistry Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
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Źródło :
Journal of biochemical and molecular toxicology [J Biochem Mol Toxicol] 2021 May; Vol. 35 (5), pp. e22736. Date of Electronic Publication: 2021 Jan 29.
Typ publikacji :
Journal Article
MeSH Terms :
Benzoquinones*/chemistry
Benzoquinones*/pharmacology
Carcinoma, Ehrlich Tumor*/drug therapy
Carcinoma, Ehrlich Tumor*/metabolism
Carcinoma, Ehrlich Tumor*/pathology
Nanoparticles*/chemistry
Nanoparticles*/therapeutic use
Zinc Oxide*/chemistry
Zinc Oxide*/pharmacology
Gene Expression Regulation, Neoplastic/*drug effects
Neoplasm Proteins/*biosynthesis
Animals ; Female ; Mice
Czasopismo naukowe
Tytuł :
Possible therapeutic effects of Nigella sativa and its thymoquinone on COVID-19.
Autorzy :
Khazdair MR; Pharmaceutical Science and Clinical Physiology, Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran.
Ghafari S; Infectious Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran.
Sadeghi M; Medical Toxicology and Drug Abuse Research Center (MTDRC), Birjand University of Medical Sciences, Birjand, Iran.
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Źródło :
Pharmaceutical biology [Pharm Biol] 2021 Dec; Vol. 59 (1), pp. 696-703.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Nigella sativa*/chemistry
Anti-Inflammatory Agents/*pharmacology
Antiviral Agents/*pharmacology
Benzoquinones/*pharmacology
COVID-19/*drug therapy
Plant Extracts/*pharmacology
SARS-CoV-2/*drug effects
Animals ; Anti-Inflammatory Agents/isolation & purification ; Antiviral Agents/isolation & purification ; Benzoquinones/isolation & purification ; COVID-19/immunology ; COVID-19/metabolism ; COVID-19/virology ; Cytokines/metabolism ; Humans ; Immune System/drug effects ; Immune System/immunology ; Immune System/metabolism ; Immune System/virology ; Inflammation Mediators/metabolism ; Lung/drug effects ; Lung/immunology ; Lung/metabolism ; Lung/virology ; Plant Extracts/isolation & purification ; SARS-CoV-2/immunology ; SARS-CoV-2/pathogenicity
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
The role of thymoquinone, a major constituent of Nigella sativa, in the treatment of inflammatory and infectious diseases.
Autorzy :
Fatima Shad K; University of Technology Sydney, Sydney, Australia.; Australian Catholic University, Sydney, Australia.; University of Health Sciences.; ISRA University.
Soubra W; University of Technology Sydney, Sydney, Australia.; Ingham Institute for Applied Medical Research.; A Health Step Clinic, Sydney, Australia.
Cordato DJ; Ingham Institute for Applied Medical Research.; Department of Neurophysiology, Liverpool Hospital, Liverpool, Australia.; South Western Sydney Clinical School, University of New South Wales, Sydney, Australia.
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Źródło :
Clinical and experimental pharmacology & physiology [Clin Exp Pharmacol Physiol] 2021 Nov; Vol. 48 (11), pp. 1445-1453. Date of Electronic Publication: 2021 Aug 18.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Benzoquinones/*pharmacology
Communicable Diseases/*drug therapy
Inflammation/*drug therapy
Nigella sativa/*chemistry
Animals ; Benzoquinones/therapeutic use ; Humans
Czasopismo naukowe
Tytuł :
Thymoquinone sensitizes human hepatocarcinoma cells to TRAIL-induced apoptosis via oxidative DNA damage.
Autorzy :
Zhang R; Department of Special Emergency Surgery, Special Medical Center of Chinese People 's Armed Police Forces, Tianjin, 300162, China.
Wu T; Department of Infectious Disease, Hainan General Hospital, Haikou, Hainan, 570311, China.
Zheng P; Department of General Surgery, the First Hospital Affiliated of Shandong First Medical University (Qianfoshan Hospital), Jinan, Shandong, 250014, China.
Liu M; Department of Infectious Disease, Hainan General Hospital, Haikou, Hainan, 570311, China.
Xu G; Department of General Surgery, Qingdao Fuwai Hospital Qingdao, Shandong, 266034, China.
Xi M; Department of Urology, Huadu District People's Hospital, Southern Medical University, Guangzhou, Guangdong, 510800, China.
Yu J; Department of General Surgery, the First Hospital Affiliated of Shandong First Medical University (Qianfoshan Hospital), Jinan, Shandong, 250014, China. Electronic address: .
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Źródło :
DNA repair [DNA Repair (Amst)] 2021 Jul; Vol. 103, pp. 103117. Date of Electronic Publication: 2021 Apr 15.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis*
DNA Damage*
Benzoquinones/*pharmacology
Carcinoma, Hepatocellular/*drug therapy
Liver Neoplasms/*drug therapy
TNF-Related Apoptosis-Inducing Ligand/*metabolism
Benzoquinones/therapeutic use ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/metabolism ; Carcinoma, Hepatocellular/physiopathology ; DNA/drug effects ; Hep G2 Cells ; Humans ; Liver Neoplasms/genetics ; Liver Neoplasms/metabolism ; Liver Neoplasms/physiopathology ; Oxidative Stress
Czasopismo naukowe
Tytuł :
Thymoquinone and Curcumin Defeat Aging-Associated Oxidative Alterations Induced by D-Galactose in Rats' Brain and Heart.
Autorzy :
El-Far AH; Department of Biochemistry, Faculty of Veterinary Medicine, Damanhour University, Damanhour 22511, Egypt.
Elewa YHA; Department of Histology, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44519, Egypt.; Laboratory of Anatomy, Faculty of Veterinary Medicine, Basic Veterinary Sciences, Hokkaido University, Sapporo 060-0818, Japan.
Abdelfattah EA; Animal Care Unit, Medical Research Institute, Alexandria University, Alexandria 21544, Egypt.
Alsenosy AA; Department of Biochemistry, Faculty of Veterinary Medicine, Damanhour University, Damanhour 22511, Egypt.
Atta MS; Department of Physiology, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh 33516, Egypt.
Abou-Zeid KM; Animal Care Unit, Medical Research Institute, Alexandria University, Alexandria 21544, Egypt.
Al Jaouni SK; Department of Hematology/Pediatric Oncology, Yousef Abdulatif Jameel Scientific Chair of Prophetic Medicine Application, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Mousa SA; Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY 12144, USA.
Noreldin AE; Histology and Cytology Department, Faculty of Veterinary Medicine, Damanhour University, Damanhour 22511, Egypt.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jun 25; Vol. 22 (13). Date of Electronic Publication: 2021 Jun 25.
Typ publikacji :
Journal Article
MeSH Terms :
Benzoquinones/*pharmacology
Brain/*drug effects
Brain/*metabolism
Curcumin/*pharmacology
Galactose/*pharmacology
Myocardium/*metabolism
Oxidation-Reduction/*drug effects
Oxidative Stress/*drug effects
Animals ; Benzoquinones/chemistry ; Curcumin/chemistry ; Immunohistochemistry ; Liver/drug effects ; Liver/metabolism ; Liver/pathology ; Organ Specificity ; Rats ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Protective roles of thymoquinone and vildagliptin in manganese-induced nephrotoxicity in adult albino rats.
Autorzy :
Mostafa HE; Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Zagazig University, Zagazig, 44519, Egypt.
Alaa El-Din EA; Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Zagazig University, Zagazig, 44519, Egypt. .
El-Shafei DA; Department of Community, Environmental & Occupational Medicine, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Abouhashem NS; Department of Pathology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Abouhashem AA; Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Zagazig University, Zagazig, 44519, Egypt.
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Źródło :
Environmental science and pollution research international [Environ Sci Pollut Res Int] 2021 Jun; Vol. 28 (24), pp. 31174-31184. Date of Electronic Publication: 2021 Feb 17.
Typ publikacji :
Journal Article
MeSH Terms :
Benzoquinones*
Manganese*/metabolism
Manganese*/toxicity
Animals ; Antioxidants/metabolism ; Kidney/metabolism ; Male ; Oxidative Stress ; Rats ; Vildagliptin/metabolism
Czasopismo naukowe
Tytuł :
Spectrophotometric and computational investigations of charge transfer complexes of chloranilic acid with tyrosine kinase inhibitors and application to development of novel universal 96-microwell assay for their determination in pharmaceutical formulations.
Autorzy :
Darwish IA; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia. Electronic address: .
Khalil NY; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
Darwish HW; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia; Department of Analytical Chemistry, Faculty of Pharmacy, Cairo University, Kasr El-Aini St., Cairo 11562, Egypt.
Alzoman NZ; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
Al-Hossaini AM; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
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Źródło :
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy [Spectrochim Acta A Mol Biomol Spectrosc] 2021 May 05; Vol. 252, pp. 119482. Date of Electronic Publication: 2021 Jan 18.
Typ publikacji :
Journal Article
MeSH Terms :
Benzoquinones*
Protein Kinase Inhibitors*
Spectrophotometry*
Drug Compounding
Czasopismo naukowe
Tytuł :
Thymoquinone: A Promising Natural Compound with Potential Benefits for COVID-19 Prevention and Cure.
Autorzy :
Badary OA; Clinical Pharmacy Practice Department, Faculty of Pharmacy, The British University in Egypt, Cairo, Egypt.; Clinical Pharmacy Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Hamza MS; Clinical Pharmacy Practice Department, Faculty of Pharmacy, The British University in Egypt, Cairo, Egypt.
Tikamdas R; Clinical Pharmacy Practice Department, Faculty of Pharmacy, The British University in Egypt, Cairo, Egypt.
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Źródło :
Drug design, development and therapy [Drug Des Devel Ther] 2021 May 03; Vol. 15, pp. 1819-1833. Date of Electronic Publication: 2021 May 03 (Print Publication: 2021).
Typ publikacji :
Journal Article; Review
MeSH Terms :
SARS-CoV-2*/chemistry
Benzoquinones/*therapeutic use
COVID-19/*drug therapy
Anti-Inflammatory Agents/pharmacology ; Antioxidants/pharmacology ; Benzoquinones/pharmacology ; COVID-19/prevention & control ; Comorbidity ; Epigenesis, Genetic ; Humans ; Molecular Docking Simulation
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Nutritional Value and Preventive Role of Nigella sativa L. and Its Main Component Thymoquinone in Cancer: An Evidenced-Based Review of Preclinical and Clinical Studies.
Autorzy :
Ansary J; Department of Clinical Sciences, Polytechnic University of Marche, 60131 Ancona, Italy.
Giampieri F; Department of Clinical Sciences, Polytechnic University of Marche, 60131 Ancona, Italy.; Department of Biochemistry, Faculty of Sciences, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Forbes-Hernandez TY; Nutrition and Food Science Group, Department of Analytical and Food Chemistry, CITACA, CACTI, University of Vigo, 36310 Vigo, Spain.
Regolo L; Department of Clinical Sciences, Polytechnic University of Marche, 60131 Ancona, Italy.
Quinzi D; Department of Clinical Sciences, Polytechnic University of Marche, 60131 Ancona, Italy.
Gracia Villar S; Research Center for Foods, Nutritional Biochemistry and Health, Universidad Europea del Atlántico, Isabel Torres 21, 39011 Santander, Spain.; Research Center for Foods, Nutritional Biochemistry and Health, Universidad Internacional Iberoamericana, Campeche 24560, Mexico.
Garcia Villena E; Research Center for Foods, Nutritional Biochemistry and Health, Universidad Europea del Atlántico, Isabel Torres 21, 39011 Santander, Spain.
Tutusaus Pifarre K; Research Center for Foods, Nutritional Biochemistry and Health, Universidad Europea del Atlántico, Isabel Torres 21, 39011 Santander, Spain.; Research Center for Foods, Nutritional Biochemistry and Health, Universidad Internacional Iberoamericana, Campeche 24560, Mexico.
Alvarez-Suarez JM; Departamento de Ingeniería en Alimentos, Colegio de Ciencias e Ingenierías, Universidad San Francisco de Quito, Quito 170157, Ecuador.; King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Battino M; Department of Clinical Sciences, Polytechnic University of Marche, 60131 Ancona, Italy.; International Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang 212013, China.
Cianciosi D; Department of Clinical Sciences, Polytechnic University of Marche, 60131 Ancona, Italy.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Apr 07; Vol. 26 (8). Date of Electronic Publication: 2021 Apr 07.
Typ publikacji :
Journal Article; Meta-Analysis; Review
MeSH Terms :
Nutritive Value*
Anticarcinogenic Agents/*chemistry
Anticarcinogenic Agents/*pharmacology
Benzoquinones/*chemistry
Benzoquinones/*pharmacology
Nigella sativa/*chemistry
Plant Extracts/*chemistry
Plant Extracts/*pharmacology
Animals ; Anticarcinogenic Agents/therapeutic use ; Benzoquinones/therapeutic use ; Biomarkers ; Clinical Studies as Topic ; Disease Susceptibility ; Drug Evaluation, Preclinical ; Humans ; Neoplasms/drug therapy ; Neoplasms/etiology ; Neoplasms/metabolism ; Neoplasms/prevention & control ; Plant Extracts/therapeutic use ; Signal Transduction/drug effects ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
The Hsp90 Inhibitor 17-DMAG Attenuates Hyperglycemia-Enhanced Hemorrhagic Transformation in Experimental Stroke.
Autorzy :
Zhang J; Department of Emergency, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, China 214023.
Wang K; Department of Neurology, Second Affiliated Hospital of Xuzhou Medical University, Xuzhou City, Jiangsu Province, China.
Qi J; Department of Pharmacy, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.
Cao X; Department of Emergency, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, China 214023.
Wang F; Department of Neurology, Shanghai 7th Hospital Affiliated to Shanghai Traditional Chinese Medical University, Shanghai, China 200000.
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Źródło :
BioMed research international [Biomed Res Int] 2021 Feb 02; Vol. 2021, pp. 6668442. Date of Electronic Publication: 2021 Feb 02 (Print Publication: 2021).
Typ publikacji :
Journal Article
MeSH Terms :
Benzoquinones*/administration & dosage
Benzoquinones*/pharmacology
Lactams, Macrocyclic*/administration & dosage
Lactams, Macrocyclic*/pharmacology
Cerebral Hemorrhage/*metabolism
HSP90 Heat-Shock Proteins/*antagonists & inhibitors
Hyperglycemia/*metabolism
Stroke/*metabolism
Animals ; Blood Glucose/drug effects ; Disease Models, Animal ; Infarction, Middle Cerebral Artery/metabolism ; Injections, Intraperitoneal ; Matrix Metalloproteinases/metabolism ; Oxidative Stress/drug effects ; Rats
Czasopismo naukowe
Tytuł :
Thymoquinone: A Tie-Breaker in SARS-CoV2-Infected Cancer Patients?
Autorzy :
Elgohary S; Molecular Pharmacology Research Group, Department of Pharmacology and Toxicology, Faculty of Pharmacy and Biotechnology, German University in Cairo, 11835 Cairo, Egypt.
Elkhodiry AA; Molecular Pharmacology Research Group, Department of Pharmacology and Toxicology, Faculty of Pharmacy and Biotechnology, German University in Cairo, 11835 Cairo, Egypt.
Amin NS; Molecular Pharmacology Research Group, Department of Pharmacology and Toxicology, Faculty of Pharmacy and Biotechnology, German University in Cairo, 11835 Cairo, Egypt.
Stein U; Experimental and Clinical Research Center, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.; Max-Delbrück-Center for Molecular Medicine, 13125 Berlin, Germany.; German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.
El Tayebi HM; Molecular Pharmacology Research Group, Department of Pharmacology and Toxicology, Faculty of Pharmacy and Biotechnology, German University in Cairo, 11835 Cairo, Egypt.
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Źródło :
Cells [Cells] 2021 Feb 02; Vol. 10 (2). Date of Electronic Publication: 2021 Feb 02.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/therapeutic use
Antiviral Agents*/pharmacology
Antiviral Agents*/therapeutic use
Benzoquinones*/pharmacology
Benzoquinones*/therapeutic use
COVID-19*/complications
COVID-19*/drug therapy
Drug Repositioning*
Neoplasms*/complications
Neoplasms*/drug therapy
Animals ; Cell Line, Tumor ; Humans ; Mice ; Rats
Czasopismo naukowe
Tytuł :
Molecular insights into the Patched1 drug efflux inhibitory activity of panicein A hydroquinone: a computational study.
Autorzy :
Kovachka S; Université Côte d'Azur, CNRS, ICN, 28 Avenue Valrose, 06108 Nice, CEDEX 2, France.
Malloci G
Vargiu AV
Azoulay S
Mus-Veteau I
Ruggerone P
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Źródło :
Physical chemistry chemical physics : PCCP [Phys Chem Chem Phys] 2021 Apr 07; Vol. 23 (13), pp. 8013-8022. Date of Electronic Publication: 2021 Feb 01.
Typ publikacji :
Journal Article
MeSH Terms :
Benzoquinones/*metabolism
Hydroquinones/*metabolism
Patched-1 Receptor/*metabolism
Benzoquinones/chemistry ; Binding Sites ; Humans ; Hydroquinones/chemistry ; Molecular Conformation ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Patched-1 Receptor/chemistry ; Protein Binding
Czasopismo naukowe
Tytuł :
Biological and therapeutic activities of thymoquinone: Focus on the Nrf2 signaling pathway.
Autorzy :
Talebi M; Department of Pharmacognosy and Pharmaceutical Biotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Talebi M; Department of Chemistry and Biochemistry, University of Texas at Arlington, Arlington, Texas, United States.; Mylan Pharmaceuticals Inc, San Antonio, Texas, United States.
Farkhondeh T; Medical Toxicology and Drug Abuse Research Center (MTDRC), Birjand University of Medical Sciences (BUMS), Birjand, Iran.; Faculty of Pharmacy, Birjand University of Medical Sciences, Birjand, Iran.
Samarghandian S; Noncommunicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran.
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Źródło :
Phytotherapy research : PTR [Phytother Res] 2021 Apr; Vol. 35 (4), pp. 1739-1753. Date of Electronic Publication: 2020 Oct 13.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Benzoquinones/*therapeutic use
NF-E2-Related Factor 2/*metabolism
Nigella sativa/*chemistry
Signal Transduction/*drug effects
Animals ; Benzoquinones/pharmacology ; Humans
Czasopismo naukowe
Tytuł :
Differential Roles of a Family of Flavodoxin-Like Proteins That Promote Resistance to Quinone-Mediated Oxidative Stress in Candida albicans.
Autorzy :
Foderaro JE; Department of Microbiology and Immunology, Stony Brook University, Stony Brook, New York, USA.
Konopka JB; Department of Microbiology and Immunology, Stony Brook University, Stony Brook, New York, USA .
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Źródło :
Infection and immunity [Infect Immun] 2021 Mar 17; Vol. 89 (4). Date of Electronic Publication: 2021 Mar 17 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Multigene Family*
Oxidative Stress*
Benzoquinones/*pharmacology
Candida albicans/*drug effects
Candida albicans/*physiology
Flavodoxin/*genetics
Fungal Proteins/*genetics
Antibodies, Fungal ; Benzoquinones/chemistry ; Drug Resistance, Fungal ; Flavodoxin/metabolism ; Fungal Proteins/metabolism ; Gene Expression Regulation, Fungal ; Lipid Peroxidation ; Microbial Sensitivity Tests
Czasopismo naukowe
Tytuł :
A Smart Hyperthermia Nanofiber-Platform-Enabled Sustained Release of Doxorubicin and 17AAG for Synergistic Cancer Therapy.
Autorzy :
Chen L; Research Center for Functional Materials, National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan.
Fujisawa N; Research Center for Functional Materials, National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan.; Graduate School of Pure and Applied Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-0006, Japan.
Takanohashi M; Research Center for Functional Materials, National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan.; Graduate School of Pure and Applied Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-0006, Japan.
Najmina M; Research Center for Functional Materials, National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan.; Graduate School of Pure and Applied Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-0006, Japan.
Uto K; Research Center for Functional Materials, National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan.
Ebara M; Research Center for Functional Materials, National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan.; Graduate School of Pure and Applied Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-0006, Japan.; Department of Materials Science and Technology, Tokyo University of Science, Tokyo 125-8585, Japan.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Mar 03; Vol. 22 (5). Date of Electronic Publication: 2021 Mar 03.
Typ publikacji :
Journal Article
MeSH Terms :
Benzoquinones/*pharmacology
Delayed-Action Preparations/*pharmacology
Doxorubicin/*pharmacology
Hyperthermia/*drug therapy
Lactams, Macrocyclic/*pharmacology
Nanofibers/*chemistry
Neoplasms/*drug therapy
Benzoquinones/chemistry ; Cell Line, Tumor ; Cell Survival/drug effects ; Delayed-Action Preparations/chemistry ; Doxorubicin/chemistry ; Drug Liberation ; Drug Synergism ; Ferric Compounds/chemistry ; Humans ; Lactams, Macrocyclic/chemistry ; MCF-7 Cells ; Magnetics/methods ; Magnetite Nanoparticles/chemistry
Czasopismo naukowe
Tytuł :
The conformation-specific Hsp90 inhibition interferes with the oncogenic RAF kinase adaptation and triggers premature cellular senescence, hence, acts as a tumor suppressor mechanism.
Autorzy :
Kanugovi Vijayavittal A; Presently at Department of Neurology & Neurological Sciences, Stanford University, USA.
Amere Subbarao S; CSIR-Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500 007, Telangana, India. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Molecular cell research [Biochim Biophys Acta Mol Cell Res] 2021 Mar; Vol. 1868 (3), pp. 118943. Date of Electronic Publication: 2020 Dec 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*administration & dosage
Benzoquinones/*administration & dosage
HSP90 Heat-Shock Proteins/*chemistry
HSP90 Heat-Shock Proteins/*metabolism
Lactams, Macrocyclic/*administration & dosage
Lung Neoplasms/*drug therapy
raf Kinases/*genetics
A549 Cells ; Animals ; Antineoplastic Agents/pharmacology ; Benzoquinones/pharmacology ; Cell Proliferation/drug effects ; Cellular Senescence ; DNA Repair/drug effects ; HEK293 Cells ; Humans ; Lactams, Macrocyclic/pharmacology ; Lung Neoplasms/genetics ; Lung Neoplasms/metabolism ; Male ; Mice ; Mutation ; Protein Conformation ; Signal Transduction/drug effects ; Xenograft Model Antitumor Assays
Czasopismo naukowe

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