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Tytuł:
Non-animal models for blood-brain barrier permeability evaluation of drug-like compounds.
Autorzy:
Dehnbostel FO; Institute for Physiology, Charité - University Medicine Berlin, 10115, Berlin, Germany.
Dixit VA; Department of Medicinal Chemistry, Department of Pharmaceuticals, National Institute of Pharmaceutical Education and Research, Guwahati, (NIPER Gu-Wahati), Ministry of Chemicals and Fertilizers, Government of India, Sila Katamur (Halugurisuk), Kamrup, P.O.: Changsari, Guwahati, Assam, 781101, India.
Preissner R; Institute for Physiology, Charité - University Medicine Berlin, 10115, Berlin, Germany.
Banerjee P; Institute for Physiology, Charité - University Medicine Berlin, 10115, Berlin, Germany. .
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Źródło:
Scientific reports [Sci Rep] 2024 Apr 17; Vol. 14 (1), pp. 8908. Date of Electronic Publication: 2024 Apr 17.
Typ publikacji:
Journal Article
MeSH Terms:
Blood-Brain Barrier*
Central Nervous System*
Biological Transport/physiology ; Machine Learning ; Permeability
Czasopismo naukowe
Tytuł:
Specific nanoprobe design for MRI: Targeting laminin in the blood-brain barrier to follow alteration due to neuroinflammation.
Autorzy:
Zapata-Acevedo JF; Grupo de Investigación en Neurociencias (NeURos), Centro de Neurociencia Neurovitae-UR, Instituto de Medicina Traslacional (IMT), Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogotá, Colombia.
Losada-Barragán M; Grupo de Biología Celular y Funcional e Ingeniería de Biomoleculas, Departamento de Biología, Universidad Antonio Nariño, Bogotá, Colombia.
Osma JF; Department of Electrical and Electronic Engineering, Universidad de los Andes, Bogotá, Colombia.; Department of Biomedical Engineering, Universidad de los Andes, Bogotá, Colombia.
Cruz JC; Department of Biomedical Engineering, Universidad de los Andes, Bogotá, Colombia.
Reiber A; Chemistry Department, Grupo La Quimica en la interfase inorgánica-orgánica QUINORG, Universidad de los Andes, Bogotá, Colombia.
Petry KG; CNRS UMR 5536 Centre de Resonance Magnétique des Systemes Biologiques and INSERM U1049 Neuroinflammation, University of Bordeaux, Bordeaux, France.
Caillard A; GREMI, UMR7344, University of Orleans, Orleans, France.
Sauldubois A; GREMI, UMR7344, University of Orleans, Orleans, France.
Llamosa Pérez D; Facultad de Ciencias, Grupo Investigación fundamental y aplicada en Materiales, Universidad Antonio Nariño, Bogotá, Colombia.
Morillo Zárate AJ; Médico Radiólogo Institucional, Fundación Santa Fé de Bogotá, Bogotá, Colombia.
Muñoz SB; Médico Radiólogo Institucional, Fundación Santa Fé de Bogotá, Bogotá, Colombia.
Daza Moreno A; Oficial de Protección Radiológica, Fundación Santa Fé de Bogotá, Bogotá, Colombia.
Silva RV; Experimental and Clinical Research Center, a Cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité-Universitätsmedizin Berlin, Berlin, Germany.
Infante-Duarte C; Experimental and Clinical Research Center, a Cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité-Universitätsmedizin Berlin, Berlin, Germany.
Chamorro-Coral W; Laboratorio de Neurofisiología Celular, Grupo de Neurociencia Traslacional, Facultad de Medicina, Universidad de los Andes, Bogotá, Colombia.
González-Reyes RE; Grupo de Investigación en Neurociencias (NeURos), Centro de Neurociencia Neurovitae-UR, Instituto de Medicina Traslacional (IMT), Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogotá, Colombia.
Vargas-Sánchez K; Laboratorio de Neurofisiología Celular, Grupo de Neurociencia Traslacional, Facultad de Medicina, Universidad de los Andes, Bogotá, Colombia.
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Źródło:
PloS one [PLoS One] 2024 Apr 11; Vol. 19 (4), pp. e0302031. Date of Electronic Publication: 2024 Apr 11 (Print Publication: 2024).
Typ publikacji:
Journal Article
MeSH Terms:
Blood-Brain Barrier*/diagnostic imaging
Blood-Brain Barrier*/metabolism
Laminin*/metabolism
Animals ; Neuroinflammatory Diseases ; Endothelial Cells/metabolism ; Inflammation/diagnostic imaging ; Inflammation/metabolism ; Magnetic Resonance Imaging/methods
Czasopismo naukowe
Tytuł:
Fasting upregulates the monocarboxylate transporter MCT1 at the rat blood-brain barrier through PPAR δ activation.
Autorzy:
Chasseigneaux S; Optimisation Thérapeutique en Neuropsychopharmacologie, Université Paris Cité, Inserm, 4 avenue de l'Observatoire, 75006, Paris, France.
Cochois-Guégan V; Optimisation Thérapeutique en Neuropsychopharmacologie, Université Paris Cité, Inserm, 4 avenue de l'Observatoire, 75006, Paris, France.
Lecorgne L; Optimisation Thérapeutique en Neuropsychopharmacologie, Université Paris Cité, Inserm, 4 avenue de l'Observatoire, 75006, Paris, France.
Lochus M; Optimisation Thérapeutique en Neuropsychopharmacologie, Université Paris Cité, Inserm, 4 avenue de l'Observatoire, 75006, Paris, France.
Nicolic S; Optimisation Thérapeutique en Neuropsychopharmacologie, Université Paris Cité, Inserm, 4 avenue de l'Observatoire, 75006, Paris, France.
Blugeon C; Département de biologie, GenomiqueENS, Institut de Biologie de l'ENS (IBENS), École normale supérieure, CNRS, INSERM, Université PSL, 75005, Paris, France.
Jourdren L; Département de biologie, GenomiqueENS, Institut de Biologie de l'ENS (IBENS), École normale supérieure, CNRS, INSERM, Université PSL, 75005, Paris, France.
Gomez-Zepeda D; Helmholtz-Institute for Translational Oncology Mainz (HI-TRON Mainz), A Hemlholtz Institute of the DKFZ, Mainz, Germany.; German Cancer Research Center (DKFZ) Heidelberg, Division 191, 69120, Heidelberg, Germany.; Institute of Immunology, University Medical Center of the Johannes-Gutenberg University, Mainz, Germany.
Tenzer S; Helmholtz-Institute for Translational Oncology Mainz (HI-TRON Mainz), A Hemlholtz Institute of the DKFZ, Mainz, Germany.; German Cancer Research Center (DKFZ) Heidelberg, Division 191, 69120, Heidelberg, Germany.; Institute of Immunology, University Medical Center of the Johannes-Gutenberg University, Mainz, Germany.; Research Center for Immunotherapy (FZI), University Medical Center of the Johannes-Gutenberg University, Mainz, Germany.
Sanquer S; AP.HP.Centre, Université Paris Cité, Paris, France.
Nivet-Antoine V; AP-HP Biochimie générale, Hôpital Necker Enfants Malades, Université Paris Cité, Inserm, Innovations Thérapeutiques en Hémostase, Paris, France.
Menet MC; Institut de Chimie Physique, CNRS UMR8000, Université Paris-Saclay, 91400, Orsay, France.
Laplanche JL; Optimisation Thérapeutique en Neuropsychopharmacologie, Université Paris Cité, Inserm, 4 avenue de l'Observatoire, 75006, Paris, France.
Declèves X; Optimisation Thérapeutique en Neuropsychopharmacologie, Université Paris Cité, Inserm, 4 avenue de l'Observatoire, 75006, Paris, France.
Cisternino S; Optimisation Thérapeutique en Neuropsychopharmacologie, Université Paris Cité, Inserm, 4 avenue de l'Observatoire, 75006, Paris, France.
Saubaméa B; Optimisation Thérapeutique en Neuropsychopharmacologie, Université Paris Cité, Inserm, 4 avenue de l'Observatoire, 75006, Paris, France. .
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Źródło:
Fluids and barriers of the CNS [Fluids Barriers CNS] 2024 Apr 08; Vol. 21 (1), pp. 33. Date of Electronic Publication: 2024 Apr 08.
Typ publikacji:
Journal Article
MeSH Terms:
Blood-Brain Barrier*/metabolism
PPAR delta*/metabolism
Rats ; Male ; Animals ; Endothelial Cells/metabolism ; Membrane Transport Proteins/metabolism ; Brain/metabolism ; Fasting
Czasopismo naukowe
Tytuł:
Focused ultrasound-mediated blood-brain barrier opening is safe and feasible with moderately hypofractionated radiotherapy for brainstem diffuse midline glioma.
Autorzy:
Tazhibi M; Department of Radiation Oncology, Columbia University Irving Medical Center, 622 W. 168th Street, New York, NY, 10032, USA.
McQuillan N; Department of Radiation Oncology, Columbia University Irving Medical Center, 622 W. 168th Street, New York, NY, 10032, USA.
Wei HJ; Department of Radiation Oncology, Columbia University Irving Medical Center, 622 W. 168th Street, New York, NY, 10032, USA.
Gallitto M; Department of Radiation Oncology, Columbia University Irving Medical Center, 622 W. 168th Street, New York, NY, 10032, USA.
Bendau E; Department of Biomedical Engineering, Columbia University, New York, NY, 10027, USA.
Webster Carrion A; Division of Pediatric Hematology Oncology and Stem Cell Transplant, Department of Pediatrics, Columbia University Irving Medical Center, 161 Fort Washington Avenue, New York, NY, 10032, USA.; Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
Berg X; Department of Radiation Oncology, Columbia University Irving Medical Center, 622 W. 168th Street, New York, NY, 10032, USA.
Kokossis D; Department of Radiation Oncology, Columbia University Irving Medical Center, 622 W. 168th Street, New York, NY, 10032, USA.
Zhang X; Division of Pediatric Hematology Oncology and Stem Cell Transplant, Department of Pediatrics, Columbia University Irving Medical Center, 161 Fort Washington Avenue, New York, NY, 10032, USA.; Institute for Cancer Genetics, Columbia University Irving Medical Center, New York, NY, 10032, USA.
Zhang Z; Division of Pediatric Hematology Oncology and Stem Cell Transplant, Department of Pediatrics, Columbia University Irving Medical Center, 161 Fort Washington Avenue, New York, NY, 10032, USA.; Institute for Cancer Genetics, Columbia University Irving Medical Center, New York, NY, 10032, USA.
Jan CI; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, 10032, USA.; Department of Pathology and Laboratory Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, 813, Taiwan.
Mintz A; Department of Radiology, Columbia University, New York, NY, 10027, USA.
Gartrell RD; Division of Pediatric Hematology Oncology and Stem Cell Transplant, Department of Pediatrics, Columbia University Irving Medical Center, 161 Fort Washington Avenue, New York, NY, 10032, USA.; Division of Pediatric Oncology, Department of Oncology, Johns Hopkins School of Medicine, Baltimore, MD, 21287, USA.
Syed HR; Department of Neurosurgery, Children's National Hospital, Washington, DC, USA.; George Washington University, Washington, DC, USA.
Fonseca A; George Washington University, Washington, DC, USA.; Center for Cancer and Blood Disorders, Children's National Hospital, Washington, DC, USA.; The Brain Tumor Institute, Children's National Hospital, Washington, DC, USA.
Pavisic J; Division of Pediatric Hematology Oncology and Stem Cell Transplant, Department of Pediatrics, Columbia University Irving Medical Center, 161 Fort Washington Avenue, New York, NY, 10032, USA.
Szalontay L; Division of Pediatric Hematology Oncology and Stem Cell Transplant, Department of Pediatrics, Columbia University Irving Medical Center, 161 Fort Washington Avenue, New York, NY, 10032, USA.
Konofagou EE; Department of Biomedical Engineering, Columbia University, New York, NY, 10027, USA.
Zacharoulis S; Division of Pediatric Hematology Oncology and Stem Cell Transplant, Department of Pediatrics, Columbia University Irving Medical Center, 161 Fort Washington Avenue, New York, NY, 10032, USA. .; Bristol Myers Squibb, Princeton, NJ, 08901, USA. .
Wu CC; Department of Radiation Oncology, Columbia University Irving Medical Center, 622 W. 168th Street, New York, NY, 10032, USA. .; Herbert Irving Comprehensive Cancer Center, New York, NY, 10032, USA. .
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Źródło:
Journal of translational medicine [J Transl Med] 2024 Mar 30; Vol. 22 (1), pp. 320. Date of Electronic Publication: 2024 Mar 30.
Typ publikacji:
Journal Article
MeSH Terms:
Blood-Brain Barrier*
Glioma*/radiotherapy
Humans ; Rats ; Child ; Male ; Mice ; Animals ; Disease Models, Animal ; Rats, Sprague-Dawley ; Brain Stem ; Drug Delivery Systems/methods ; Magnetic Resonance Imaging ; Microbubbles ; Brain
Czasopismo naukowe
Tytuł:
Inflammation-induced TRPV4 channels exacerbate blood-brain barrier dysfunction in multiple sclerosis.
Autorzy:
Hansen CE; Department of Molecular Cell Biology and Immunology, Amsterdam UMC Location Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands. .; Amsterdam Neuroscience, Amsterdam UMC, Amsterdam, The Netherlands. .; MS Center Amsterdam, Amsterdam UMC Location VU Medical Center, Amsterdam, The Netherlands. .
Kamermans A; Department of Molecular Cell Biology and Immunology, Amsterdam UMC Location Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands.; Amsterdam Neuroscience, Amsterdam UMC, Amsterdam, The Netherlands.; MS Center Amsterdam, Amsterdam UMC Location VU Medical Center, Amsterdam, The Netherlands.
Mol K; Department of Biomedical Engineering and Physics, Amsterdam UMC Location University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands.
Berve K; Theodor Kocher Institute, University of Bern, Bern, Switzerland.
Rodriguez-Mogeda C; Department of Molecular Cell Biology and Immunology, Amsterdam UMC Location Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands.; Amsterdam Neuroscience, Amsterdam UMC, Amsterdam, The Netherlands.; MS Center Amsterdam, Amsterdam UMC Location VU Medical Center, Amsterdam, The Netherlands.
Fung WK; Department of Molecular Cell Biology and Immunology, Amsterdam UMC Location Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands.
van Het Hof B; Department of Molecular Cell Biology and Immunology, Amsterdam UMC Location Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands.
Fontijn RD; Department of Molecular Cell Biology and Immunology, Amsterdam UMC Location Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands.
van der Pol SMA; Department of Molecular Cell Biology and Immunology, Amsterdam UMC Location Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands.
Michalick L; Institute of Physiology, Corporate member of the Freie Universität Berlin and Humboldt Universität to Berlin, Charité-Universitätsmedizin Berlin, Berlin, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Berlin, Germany.
Kuebler WM; Institute of Physiology, Corporate member of the Freie Universität Berlin and Humboldt Universität to Berlin, Charité-Universitätsmedizin Berlin, Berlin, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Berlin, Germany.; Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, ON, Canada.; Departments of Surgery and Physiology, University of Toronto, Toronto, ON, Canada.
Kenkhuis B; Department of Human Genetics, Leiden University Medical Center Leiden, Leiden, The Netherlands.; UK Dementia Research Institute at University of Edinburgh, Edinburgh, UK.
van Roon-Mom W; Department of Human Genetics, Leiden University Medical Center Leiden, Leiden, The Netherlands.
Liedtke W; Department of Neurology, Duke University, Durham, NY, USA.; Department of Molecular Pathobiology, New York University College of Dentistry, New York, USA.
Engelhardt B; Theodor Kocher Institute, University of Bern, Bern, Switzerland.
Kooij G; Department of Molecular Cell Biology and Immunology, Amsterdam UMC Location Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands.; Amsterdam Neuroscience, Amsterdam UMC, Amsterdam, The Netherlands.; MS Center Amsterdam, Amsterdam UMC Location VU Medical Center, Amsterdam, The Netherlands.; Amsterdam Institute for Immunology and Infectious Diseases, Amsterdam UMC, Amsterdam, The Netherlands.
Witte ME; Department of Molecular Cell Biology and Immunology, Amsterdam UMC Location Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands.; Amsterdam Neuroscience, Amsterdam UMC, Amsterdam, The Netherlands.; MS Center Amsterdam, Amsterdam UMC Location VU Medical Center, Amsterdam, The Netherlands.; Amsterdam Institute for Immunology and Infectious Diseases, Amsterdam UMC, Amsterdam, The Netherlands.
de Vries HE; Department of Molecular Cell Biology and Immunology, Amsterdam UMC Location Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands. .; Amsterdam Neuroscience, Amsterdam UMC, Amsterdam, The Netherlands. .; MS Center Amsterdam, Amsterdam UMC Location VU Medical Center, Amsterdam, The Netherlands. .
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Źródło:
Journal of neuroinflammation [J Neuroinflammation] 2024 Mar 23; Vol. 21 (1), pp. 72. Date of Electronic Publication: 2024 Mar 23.
Typ publikacji:
Journal Article
MeSH Terms:
Blood-Brain Barrier*/metabolism
Multiple Sclerosis*/pathology
TRPV Cation Channels*/metabolism
Humans ; Central Nervous System/metabolism ; Inflammation/metabolism
Czasopismo naukowe
Tytuł:
Abcg2a is the functional homolog of human ABCG2 expressed at the zebrafish blood-brain barrier.
Autorzy:
Thomas JR; Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Room 2108, Bethesda, MD, 20892, USA.
Frye WJE; Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Room 2108, Bethesda, MD, 20892, USA.
Robey RW; Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Room 2108, Bethesda, MD, 20892, USA.
Warner AC; Molecular Histopathology Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Butcher D; Molecular Histopathology Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Matta JL; Molecular Histopathology Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Morgan TC; Molecular Histopathology Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Edmondson EF; Molecular Histopathology Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Salazar PB; Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Room 2108, Bethesda, MD, 20892, USA.
Ambudkar SV; Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Room 2108, Bethesda, MD, 20892, USA.
Gottesman MM; Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Room 2108, Bethesda, MD, 20892, USA. .
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Źródło:
Fluids and barriers of the CNS [Fluids Barriers CNS] 2024 Mar 15; Vol. 21 (1), pp. 27. Date of Electronic Publication: 2024 Mar 15.
Typ publikacji:
Journal Article
MeSH Terms:
ATP Binding Cassette Transporter, Subfamily G, Member 2*/genetics
ATP Binding Cassette Transporter, Subfamily G, Member 2*/metabolism
Blood-Brain Barrier*/metabolism
Zebrafish*/metabolism
Adult ; Animals ; Humans ; Endothelial Cells/metabolism ; HEK293 Cells ; Mammals/metabolism ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism
Czasopismo naukowe
Tytuł:
Anti-Inflammatory Action of Resveratrol in the Central Nervous System in Relation to Glucose Concentration-An In Vitro Study on a Blood-Brain Barrier Model.
Autorzy:
Komorowska J; Laboratory of the Blood-Brain Barrier, Department of Biophysics, Physiology and Pathophysiology, Medical University of Warsaw, Chalubinskiego 5, 02-004 Warsaw, Poland.
Wątroba M; Laboratory of the Blood-Brain Barrier, Department of Biophysics, Physiology and Pathophysiology, Medical University of Warsaw, Chalubinskiego 5, 02-004 Warsaw, Poland.
Bednarzak M; Laboratory of the Blood-Brain Barrier, Department of Biophysics, Physiology and Pathophysiology, Medical University of Warsaw, Chalubinskiego 5, 02-004 Warsaw, Poland.
Grabowska AD; Laboratory of the Blood-Brain Barrier, Department of Biophysics, Physiology and Pathophysiology, Medical University of Warsaw, Chalubinskiego 5, 02-004 Warsaw, Poland.
Szukiewicz D; Laboratory of the Blood-Brain Barrier, Department of Biophysics, Physiology and Pathophysiology, Medical University of Warsaw, Chalubinskiego 5, 02-004 Warsaw, Poland.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Mar 07; Vol. 25 (6). Date of Electronic Publication: 2024 Mar 07.
Typ publikacji:
Journal Article
MeSH Terms:
Blood-Brain Barrier*/metabolism
Hyperglycemia*/drug therapy
Animals ; Humans ; Resveratrol/pharmacology ; Endothelial Cells/metabolism ; Lipopolysaccharides/toxicity ; Anti-Inflammatory Agents/pharmacology ; Cytokines/metabolism ; Glucose/pharmacology
Czasopismo naukowe
Tytuł:
The proteome of the blood-brain barrier in rat and mouse: highly specific identification of proteins on the luminal surface of brain microvessels by in vivo glycocapture.
Autorzy:
Tremblay TL; Human Health Therapeutics, National Research Council Canada, 100 Sussex Dr., Ottawa, ON, K1A 0R6, Canada.
Alata W; Human Health Therapeutics, National Research Council Canada, 100 Sussex Dr., Ottawa, ON, K1A 0R6, Canada.; Biology Program, New York University Abu Dhabi, Saadiyat Island Campus, P.O. Box 129188, Abu Dhabi, United Arab Emirates.
Slinn J; Human Health Therapeutics, National Research Council Canada, 100 Sussex Dr., Ottawa, ON, K1A 0R6, Canada.
Baumann E; Human Health Therapeutics, National Research Council Canada, 100 Sussex Dr., Ottawa, ON, K1A 0R6, Canada.
Delaney CE; Human Health Therapeutics, National Research Council Canada, 100 Sussex Dr., Ottawa, ON, K1A 0R6, Canada.
Moreno M; Human Health Therapeutics, National Research Council Canada, 100 Sussex Dr., Ottawa, ON, K1A 0R6, Canada.
Haqqani AS; Human Health Therapeutics, National Research Council Canada, 100 Sussex Dr., Ottawa, ON, K1A 0R6, Canada.
Stanimirovic DB; Human Health Therapeutics, National Research Council Canada, 100 Sussex Dr., Ottawa, ON, K1A 0R6, Canada.
Hill JJ; Human Health Therapeutics, National Research Council Canada, 100 Sussex Dr., Ottawa, ON, K1A 0R6, Canada. .
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Źródło:
Fluids and barriers of the CNS [Fluids Barriers CNS] 2024 Mar 04; Vol. 21 (1), pp. 23. Date of Electronic Publication: 2024 Mar 04.
Typ publikacji:
Journal Article
MeSH Terms:
Blood-Brain Barrier*
Proteome*
Rats ; Mice ; Animals ; Endothelial Cells ; Proteomics ; Brain ; Microvessels ; Membrane Proteins ; Polysaccharides
Czasopismo naukowe
Tytuł:
CYP1B1 affects the integrity of the blood-brain barrier and oxidative stress in the striatum: An investigation of manganese-induced neurotoxicity.
Autorzy:
Wu J; Department of Pharmacology, School of Basic Medical Sciences, Wuhan University, Wuhan, China.; Department of Pharmacy, Taikang Tongji (Wuhan) Hospital, Wuhu, China.
Li Y; Department of Pharmacology, School of Basic Medical Sciences, Wuhan University, Wuhan, China.; Department of Pharmacy, The First Affiliated Hospital of Wannan Medical College, Wuhu, China.
Tian S; Department of Pharmacology, School of Basic Medical Sciences, Wuhan University, Wuhan, China.
Na S; Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan, Hubei, China.
Wei H; Department of Pharmacology, School of Basic Medical Sciences, Wuhan University, Wuhan, China.
Wu Y; Department of Pharmacology, School of Basic Medical Sciences, Wuhan University, Wuhan, China.
Yang Y; Department of Pharmacology, School of Basic Medical Sciences, Wuhan University, Wuhan, China.
Shen Z; Department of Pharmacology, School of Basic Medical Sciences, Wuhan University, Wuhan, China.
Ding J; Department of Pharmacology, School of Basic Medical Sciences, Wuhan University, Wuhan, China.
Bao S; Department of Pharmacology, School of Basic Medical Sciences, Wuhan University, Wuhan, China.
Liu S; Department of Pharmacology, School of Basic Medical Sciences, Wuhan University, Wuhan, China.
Li L; Department of Pharmacology, School of Basic Medical Sciences, Wuhan University, Wuhan, China.
Feng R; Department of Pharmacology, School of Basic Medical Sciences, Wuhan University, Wuhan, China.
Zhu Y; Department of Pharmacology, School of Basic Medical Sciences, Wuhan University, Wuhan, China.
He C; Demonstration Center for Experimental Basic Medicine Education, School of Basic Medical Sciences, Wuhan University, Wuhan, China.
Yue J; Department of Pharmacology, School of Basic Medical Sciences, Wuhan University, Wuhan, China.; Hubei Province Key Laboratory of Allergy and Immunology, Wuhan, China.
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Źródło:
CNS neuroscience & therapeutics [CNS Neurosci Ther] 2024 Mar; Vol. 30 (3), pp. e14633.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Blood-Brain Barrier*/metabolism
Cytochrome P-450 CYP1B1*/metabolism
Neuroblastoma*
Animals ; Humans ; Mice ; alpha-Synuclein/metabolism ; Biotin/metabolism ; Dopamine/metabolism ; Endothelial Cells/metabolism ; Manganese/toxicity ; Oxidative Stress
Czasopismo naukowe
Tytuł:
Selective HDAC6 inhibition protects against blood-brain barrier dysfunction after intracerebral hemorrhage.
Autorzy:
Peng C; Department of Neurology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.; Department of Neurology, Hunan Provincial Rehabilitation Hospital, Hunan University of Medicine, Changsha, Hunan, China.
Wang Y; Department of Neurology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Hu Z; Department of Neurology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Chen C; Department of Neurology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
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Źródło:
CNS neuroscience & therapeutics [CNS Neurosci Ther] 2024 Mar; Vol. 30 (3), pp. e14429. Date of Electronic Publication: 2023 Sep 04.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Blood-Brain Barrier*/metabolism
Tubulin*/metabolism
Animals ; Humans ; Rats ; Brain/metabolism ; Cerebral Hemorrhage/complications ; Cerebral Hemorrhage/drug therapy ; Cerebral Hemorrhage/genetics ; Disease Models, Animal ; Endothelial Cells/metabolism ; Histone Deacetylase 6/metabolism
Czasopismo naukowe
Tytuł:
Electroacupuncture stimulation enhances the permeability of the blood-brain barrier: A systematic review and meta-analysis of preclinical evidence and possible mechanisms.
Autorzy:
Xu N; The Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, China.
Gong P; The Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, China.; The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
Xu S; The Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, China.
Chen Y; The Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, China.
Dai M; The Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, China.
Jia Z; The Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, China.
Lin X; The Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, China.; The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
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Źródło:
PloS one [PLoS One] 2024 Mar 27; Vol. 19 (3), pp. e0298533. Date of Electronic Publication: 2024 Mar 27 (Print Publication: 2024).
Typ publikacji:
Meta-Analysis; Systematic Review; Journal Article
MeSH Terms:
Blood-Brain Barrier*/metabolism
Electroacupuncture*
Rats ; Animals ; Vascular Endothelial Growth Factor A/metabolism ; Matrix Metalloproteinase 9/metabolism ; Rats, Sprague-Dawley ; ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism ; ATP Binding Cassette Transporter, Subfamily B/metabolism ; Permeability
Czasopismo naukowe
Tytuł:
17-Oxime ethers of oxidized ecdysteroid derivatives modulate oxidative stress in human brain endothelial cells and dose-dependently might protect or damage the blood-brain barrier.
Autorzy:
Vágvölgyi M; Institute of Pharmacognosy, University of Szeged, Szeged, Hungary.
Laczkó D; Institute of Pharmacognosy, University of Szeged, Szeged, Hungary.
Santa-Maria AR; Institute of Biophysics, HUN-REN Biological Research Centre, Szeged, Hungary.; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, United States of America.
Vigh JP; Institute of Biophysics, HUN-REN Biological Research Centre, Szeged, Hungary.; Doctoral School of Biology, University of Szeged, Szeged, Hungary.
Walter FR; Institute of Biophysics, HUN-REN Biological Research Centre, Szeged, Hungary.
Berkecz R; Institute of Pharmaceutical Analysis, University of Szeged, Szeged, Hungary.
Deli MA; Institute of Biophysics, HUN-REN Biological Research Centre, Szeged, Hungary.
Tóth G; NMR Group, Department of Inorganic and Analytical Chemistry, Budapest University of Technology and Economics, Budapest, Hungary.
Hunyadi A; Institute of Pharmacognosy, University of Szeged, Szeged, Hungary.; Interdisciplinary Centre of Natural Products, University of Szeged, Szeged, Hungary.; HUN-REN-SZTE Biologically Active Natural Products Research Group, Szeged, Hungary.
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Źródło:
PloS one [PLoS One] 2024 Feb 22; Vol. 19 (2), pp. e0290526. Date of Electronic Publication: 2024 Feb 22 (Print Publication: 2024).
Typ publikacji:
Journal Article
MeSH Terms:
Ecdysteroids*
Blood-Brain Barrier*
Animals ; Humans ; Endothelial Cells ; Ethers ; Oximes/pharmacology ; Oxidative Stress ; Mammals
Czasopismo naukowe
Tytuł:
Endothelial and mural laminin-α5 contributes to neurovascular integrity maintenance.
Autorzy:
Nirwane A; Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd., MDC 8, 33612, Tampa, FL, USA.
Kang M; Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd., MDC 8, 33612, Tampa, FL, USA.
Adithan A; Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd., MDC 8, 33612, Tampa, FL, USA.
Maharaj V; Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd., MDC 8, 33612, Tampa, FL, USA.
Nguyen F; Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd., MDC 8, 33612, Tampa, FL, USA.
Santaella Aguilar E; Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd., MDC 8, 33612, Tampa, FL, USA.
Nasrollahi A; Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd., MDC 8, 33612, Tampa, FL, USA.
Yao Y; Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd., MDC 8, 33612, Tampa, FL, USA. .
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Źródło:
Fluids and barriers of the CNS [Fluids Barriers CNS] 2024 Feb 21; Vol. 21 (1), pp. 18. Date of Electronic Publication: 2024 Feb 21.
Typ publikacji:
Journal Article
MeSH Terms:
Blood-Brain Barrier*/metabolism
Endothelial Cells*/metabolism
Animals ; Mice ; Astrocytes/metabolism ; Endothelium/metabolism ; Laminin/metabolism ; Mice, Knockout
Czasopismo naukowe
Tytuł:
The Role of the Vascular System in Degenerative Diseases: Mechanisms and Implications.
Autorzy:
Sheikh AM; Department of Laboratory Medicine, Faculty of Medicine, Shimane University, 89-1 Enya Cho, Izumo 693-8501, Japan.
Yano S; Department of Laboratory Medicine, Faculty of Medicine, Shimane University, 89-1 Enya Cho, Izumo 693-8501, Japan.
Tabassum S; Department of Laboratory Medicine, Faculty of Medicine, Shimane University, 89-1 Enya Cho, Izumo 693-8501, Japan.
Nagai A; Department of Laboratory Medicine, Faculty of Medicine, Shimane University, 89-1 Enya Cho, Izumo 693-8501, Japan.; Department of Neurology, Faculty of Medicine, Shimane University, 89-1 Enya Cho, Izumo 693-8501, Japan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 11; Vol. 25 (4). Date of Electronic Publication: 2024 Feb 11.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Blood-Brain Barrier*/pathology
Neurodegenerative Diseases*/pathology
Humans ; Cerebrovascular Circulation ; Biological Transport ; Homeostasis
Czasopismo naukowe
Tytuł:
Vulnerability of the Hippocampus to Insults: Links to Blood-Brain Barrier Dysfunction.
Autorzy:
Davidson TL; Department of Neuroscience, Center for Neuroscience and Behavior, American University, 4400 Massachusetts Avenue, NW, Washington, DC 20016, USA.
Stevenson RJ; Department of Psychology, Macquarie University, Sydney, NSW 2109, Australia.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 06; Vol. 25 (4). Date of Electronic Publication: 2024 Feb 06.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Blood-Brain Barrier*/metabolism
Neurodegenerative Diseases*/metabolism
Humans ; Hippocampus/metabolism ; Brain ; Aging/metabolism
Czasopismo naukowe
Tytuł:
In the Rat Hippocampus, Pilocarpine-Induced Status Epilepticus Is Associated with Reactive Glia and Concomitant Increased Expression of CD31, PDGFRβ, and Collagen IV in Endothelial Cells and Pericytes of the Blood-Brain Barrier.
Autorzy:
Kyriatzis G; Aix-Marseille Univ, CNRS, INP, Inst Neurophysiopathol, Marseille, France, Institut de Neurophysiopathologie, Faculté de Médecine, 27 Bd Jean Moulin, 13005 Marseille, France.
Bernard A; Aix-Marseille Univ, CNRS, INP, Inst Neurophysiopathol, Marseille, France, Institut de Neurophysiopathologie, Faculté de Médecine, 27 Bd Jean Moulin, 13005 Marseille, France.
Bôle A; Aix-Marseille Univ, CNRS, INP, Inst Neurophysiopathol, Marseille, France, Institut de Neurophysiopathologie, Faculté de Médecine, 27 Bd Jean Moulin, 13005 Marseille, France.
Khrestchatisky M; Aix-Marseille Univ, CNRS, INP, Inst Neurophysiopathol, Marseille, France, Institut de Neurophysiopathologie, Faculté de Médecine, 27 Bd Jean Moulin, 13005 Marseille, France.
Ferhat L; Aix-Marseille Univ, CNRS, INP, Inst Neurophysiopathol, Marseille, France, Institut de Neurophysiopathologie, Faculté de Médecine, 27 Bd Jean Moulin, 13005 Marseille, France.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Jan 30; Vol. 25 (3). Date of Electronic Publication: 2024 Jan 30.
Typ publikacji:
Journal Article
MeSH Terms:
Blood-Brain Barrier*/metabolism
Epilepsy*/metabolism
Epilepsy, Temporal Lobe*/chemically induced
Epilepsy, Temporal Lobe*/metabolism
Status Epilepticus*/metabolism
Receptor, Platelet-Derived Growth Factor beta*/genetics
Receptor, Platelet-Derived Growth Factor beta*/metabolism
Animals ; Humans ; Rats ; Collagen/metabolism ; Disease Models, Animal ; Endothelial Cells/metabolism ; Hippocampus/metabolism ; Neuroglia/metabolism ; Pericytes/metabolism ; Pilocarpine/adverse effects ; Rats, Sprague-Dawley ; Platelet Endothelial Cell Adhesion Molecule-1/genetics ; Platelet Endothelial Cell Adhesion Molecule-1/metabolism ; Receptors, Platelet-Derived Growth Factor/genetics ; Receptors, Platelet-Derived Growth Factor/metabolism
Czasopismo naukowe
Tytuł:
Recapitulation of Structure-Function-Regulation of Blood-Brain Barrier under (Patho)Physiological Conditions.
Autorzy:
Fong H; Faculty of Medicine, International School, Jinan University, Guangzhou 510632, China.
Zhou B; Department of Physiology, Basic Medical and Public Health School, Jinan University, Guangzhou 510632, China.
Feng H; Gies College of Business, University of Illinois Urbana-Champaign, Urbana-Champaign, IL 61801, USA.
Luo C; Faculty of Medicine, International School, Jinan University, Guangzhou 510632, China.
Bai B; Faculty of Medicine, International School, Jinan University, Guangzhou 510632, China.
Zhang J; Department of Physiology and Pharmacology, Loma Linda University, Loma Linda, CA 92350, USA.; Department of Neurosurgery, Loma Linda University, Loma Linda, CA 92350, USA.
Wang Y; Department of Physiology, Basic Medical and Public Health School, Jinan University, Guangzhou 510632, China.
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Źródło:
Cells [Cells] 2024 Jan 30; Vol. 13 (3). Date of Electronic Publication: 2024 Jan 30.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Blood-Brain Barrier*
Endothelial Cells*
Brain/pathology ; Central Nervous System ; Astrocytes
Czasopismo naukowe
Tytuł:
Magnetic resonance imaging with upconversion nanoprobes capable of crossing the blood-cerebrospinal fluid barrier.
Autorzy:
Han F; Department of Radiology, Huashan Hospital, Fudan University, Shanghai, 200040, P.R. China.
Gao J; Department of Radiology, Huashan Hospital, Fudan University, Shanghai, 200040, P.R. China.
Lv G; Department of Materials Science and State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, 200433, P.R. China.
Liu T; Department of Oncology, Huashan Hospital, Fudan University, Shanghai, 200040, P.R. China.
Hu Q; Department of Urology, Huashan Hospital, Fudan University, Shanghai, 200040, P.R. China.
Zhu M; Department of Radiology, Huashan Hospital, Fudan University, Shanghai, 200040, P.R. China.
Du Z; Department of Pathology, Huashan Hospital, Fudan University, Shanghai, 200040, P.R. China.
Yang J; Department of Radiology, Huashan Hospital, Fudan University, Shanghai, 200040, P.R. China.
Yao Z; Department of Radiology, Huashan Hospital, Fudan University, Shanghai, 200040, P.R. China.
Fang X; Department of Medical Imaging, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, Jiangsu Province, 214023, P.R. China. xiangming_.
Ni D; Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, P.R. China. .
Zhang J; Department of Radiology, Huashan Hospital, Fudan University, Shanghai, 200040, P.R. China. jiawen_.
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Źródło:
Journal of nanobiotechnology [J Nanobiotechnology] 2024 Jan 30; Vol. 22 (1), pp. 43. Date of Electronic Publication: 2024 Jan 30.
Typ publikacji:
Journal Article
MeSH Terms:
Blood-Brain Barrier*
Brain*/diagnostic imaging
Central Nervous System ; Biological Transport/physiology ; Magnetic Resonance Imaging
Czasopismo naukowe
Tytuł:
The Cellular Dysfunction of the Brain-Blood Barrier from Endothelial Cells to Astrocytes: The Pathway towards Neurotransmitter Impairment in Schizophrenia.
Autorzy:
Stanca S; Department of Surgical, Medical, Molecular Pathology and Critical Area, University of Pisa, Via Savi 10, 56126 Pisa, Italy.; NeuroCare Onlus, 56100 Pisa, Italy.
Rossetti M; Department of Surgical, Medical, Molecular Pathology and Critical Area, University of Pisa, Via Savi 10, 56126 Pisa, Italy.; NeuroCare Onlus, 56100 Pisa, Italy.
Bokulic Panichi L; NeuroCare Onlus, 56100 Pisa, Italy.; Neuroscience Department, Azienda Ospedaliero-Universitaria Pisana, 56100 Pisa, Italy.
Bongioanni P; NeuroCare Onlus, 56100 Pisa, Italy.; Neuroscience Department, Azienda Ospedaliero-Universitaria Pisana, 56100 Pisa, Italy.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Jan 19; Vol. 25 (2). Date of Electronic Publication: 2024 Jan 19.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Blood-Brain Barrier*/metabolism
Schizophrenia*/metabolism
Humans ; Astrocytes/metabolism ; Endothelial Cells/metabolism ; Brain/metabolism ; Pericytes/metabolism
Czasopismo naukowe
Tytuł:
Heparan Sulfate Modulation Affects Breast Cancer Cell Adhesion and Transmigration across In Vitro Blood-Brain Barrier.
Autorzy:
Li Y; Department of Biomedical Engineering, The City College of the City University of New York, New York, NY 10031, USA.
Shteyman DB; Department of Biomedical Engineering, The City College of the City University of New York, New York, NY 10031, USA.
Hachem Z; Department of Natural Sciences, CASL, University of Michigan-Dearborn, Dearborn, MI 48128, USA.
Ulay AA; Department of Biomedical Engineering, The City College of the City University of New York, New York, NY 10031, USA.
Fan J; Department of Natural Sciences, CASL, University of Michigan-Dearborn, Dearborn, MI 48128, USA.
Fu BM; Department of Biomedical Engineering, The City College of the City University of New York, New York, NY 10031, USA.
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Źródło:
Cells [Cells] 2024 Jan 19; Vol. 13 (2). Date of Electronic Publication: 2024 Jan 19.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms:
Blood-Brain Barrier*/pathology
Breast Neoplasms*/pathology
Humans ; Female ; Vascular Endothelial Growth Factor A/metabolism ; Endothelial Cells/metabolism ; Cell Adhesion ; Vascular Endothelial Growth Factors/metabolism
Czasopismo naukowe

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