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Wyszukujesz frazę ""BLOOD-brain barrier"" wg kryterium: Temat


Tytuł :
Assessment of brain-to-blood drug distribution using liquid chromatography.
Autorzy :
El Zahar NM; Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, GA, USA.; Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.; Medicinal Chemistry Department, Faculty of Pharmacy, King Salman International University, Ras-Sedr, South Sinai Governorate, Egypt.
Sutton JM; Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, GA, USA.
Bartlett MG; Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, GA, USA.
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Źródło :
Biomedical chromatography : BMC [Biomed Chromatogr] 2021 Jul; Vol. 35 (7), pp. e5123. Date of Electronic Publication: 2021 Apr 30.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Analytic Sample Preparation Methods*
Blood-Brain Barrier*/drug effects
Blood-Brain Barrier*/metabolism
Blood-Brain Barrier*/physiology
Chromatography, High Pressure Liquid*
Tandem Mass Spectrometry*
Animals ; Brain/metabolism ; Brain Chemistry ; Drug Delivery Systems ; Pharmaceutical Preparations/analysis ; Pharmaceutical Preparations/metabolism ; Pharmacokinetics ; Specimen Handling ; Spectrophotometry, Ultraviolet
Czasopismo naukowe
Tytuł :
Celastrol protects against early brain injury after subarachnoid hemorrhage in rats through alleviating blood-brain barrier disruption and blocking necroptosis.
Autorzy :
Xu H; Department of Neurosurgery, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou 310016, China.
Cai Y; School of Medicine, Zhejiang University, Hangzhou 310012, China.
Yu M; School of Medicine, Zhejiang University, Hangzhou 310012, China.
Sun J; School of Medicine, Zhejiang University, Hangzhou 310012, China.
Cai J; Neurointensive Care Unit, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou 310016, China.
Li J; Neurointensive Care Unit, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou 310016, China.
Qin B; Department of Neurosurgery, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou 310016, China.
Ying G; Department of Neurosurgery, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou 310016, China.
Chen T; Department of Neurosurgery, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou 310016, China.
Shen Y; Department of Neurosurgery, Hangzhou First People's Hospital, Hangzhou 310006, China.
Jie L; Department of Radiology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou 310016, China.
Xu D; Department of Radiology, Peking University Shenzhen Hospital, Shenzhen 518034, China.
Gu C; Department of Neurosurgery, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou 310016, China.
Wang C; Department of Neurosurgery, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou 310016, China.
Hu X; School of Medicine, Zhejiang University, Hangzhou 310012, China.
Chen J; Department of Neurosurgery, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou 310016, China.
Wang L; Department of Neurosurgery, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou 310016, China.
Chen G; Department of Neurosurgery, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou 310016, China.
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Źródło :
Aging [Aging (Albany NY)] 2021 Jun 28; Vol. 13 (12), pp. 16816-16833. Date of Electronic Publication: 2021 Jun 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Blood-Brain Barrier/*pathology
Brain Injuries/*drug therapy
Brain Injuries/*etiology
Necroptosis/*drug effects
Neuroprotective Agents/*therapeutic use
Pentacyclic Triterpenes/*therapeutic use
Subarachnoid Hemorrhage/*complications
Albumins/metabolism ; Animals ; Blood-Brain Barrier/diagnostic imaging ; Blood-Brain Barrier/drug effects ; Brain Edema/complications ; Brain Edema/diagnostic imaging ; Brain Edema/drug therapy ; Brain Injuries/diagnostic imaging ; Cerebral Ventricles/drug effects ; Cerebral Ventricles/pathology ; Down-Regulation/drug effects ; Inflammation/pathology ; Male ; Matrix Metalloproteinase 9/metabolism ; Neuroprotective Agents/pharmacology ; Organ Size/drug effects ; Pentacyclic Triterpenes/pharmacology ; Protein Kinases/metabolism ; Rats, Sprague-Dawley ; Receptor-Interacting Protein Serine-Threonine Kinases/metabolism ; Signal Transduction/drug effects ; Subarachnoid Hemorrhage/diagnostic imaging ; Survival Analysis ; Tight Junctions/drug effects ; Tight Junctions/metabolism ; Up-Regulation/drug effects
Czasopismo naukowe
Tytuł :
Integrin-dependent migratory switches regulate the translocation of Toxoplasma-infected dendritic cells across brain endothelial monolayers.
Autorzy :
Ross EC; Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.
Ten Hoeve AL; Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.
Barragan A; Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden. .
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Źródło :
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2021 Jun; Vol. 78 (12), pp. 5197-5212. Date of Electronic Publication: 2021 May 22.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Movement*
Blood-Brain Barrier/*parasitology
Dendritic Cells/*parasitology
Endothelium, Vascular/*parasitology
Integrins/*metabolism
Toxoplasma/*physiology
Toxoplasmosis/*parasitology
Animals ; Blood-Brain Barrier/immunology ; Blood-Brain Barrier/metabolism ; Cell Adhesion ; Dendritic Cells/metabolism ; Endothelium, Vascular/immunology ; Endothelium, Vascular/metabolism ; Female ; Host-Parasite Interactions ; Integrins/genetics ; Male ; Mice ; Mice, Inbred C57BL ; Toxoplasmosis/immunology ; Toxoplasmosis/metabolism ; Toxoplasmosis/pathology
Czasopismo naukowe
Tytuł :
Cycloastragenol inhibits Aβ 1-42 -induced blood-brain barrier disruption and enhances soluble Aβ efflux in vitro .
Autorzy :
Huang MY; Department of Neurology, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China.
Yu GR; Department of Neurology, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China.
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Źródło :
Journal of Asian natural products research [J Asian Nat Prod Res] 2021 Jun; Vol. 23 (6), pp. 556-569. Date of Electronic Publication: 2020 Jul 01.
Typ publikacji :
Journal Article
MeSH Terms :
Amyloid beta-Peptides*/metabolism
Blood-Brain Barrier*/drug effects
Blood-Brain Barrier*/metabolism
Sapogenins/*pharmacology
Animals ; Cell Line ; Mice ; Molecular Structure ; Peptide Fragments
Czasopismo naukowe
Tytuł :
GYY4137 protected the integrity of the blood-brain barrier via activation of the Nrf2/ARE pathway in mice with sepsis.
Autorzy :
Cui W; Department of Neurology, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Chen J; Department of Neurology, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Yu F; Department of Neurology, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Liu W; Department of Neurology, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
He M; Department of Neurology, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
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Źródło :
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2021 Jul; Vol. 35 (7), pp. e21710.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Blood-Brain Barrier/*drug effects
Morpholines/*pharmacology
NF-E2-Related Factor 2/*metabolism
Organothiophosphorus Compounds/*pharmacology
Sepsis/*drug therapy
Signal Transduction/*drug effects
Animals ; Apoptosis/drug effects ; Biological Transport/drug effects ; Blood-Brain Barrier/metabolism ; Brain/drug effects ; Brain/metabolism ; Disease Models, Animal ; Hydrogen Sulfide/pharmacology ; Kelch-Like ECH-Associated Protein 1/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Oxidative Stress/drug effects ; Sepsis/metabolism
Czasopismo naukowe
Tytuł :
Noncontrast assessment of blood-brain barrier permeability to water: Shorter acquisition, test-retest reproducibility, and comparison with contrast-based method.
Autorzy :
Lin Z; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; The Russell H. Morgan Department of Radiology & Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Jiang D; The Russell H. Morgan Department of Radiology & Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Liu D; The Russell H. Morgan Department of Radiology & Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, Maryland, USA.
Li Y; The Russell H. Morgan Department of Radiology & Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Uh J; Department of Radiation Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Hou X; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; The Russell H. Morgan Department of Radiology & Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Pillai JJ; The Russell H. Morgan Department of Radiology & Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Qin Q; The Russell H. Morgan Department of Radiology & Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, Maryland, USA.
Ge Y; Department of Radiology, New York University Langone Medical Center, New York, New York, USA.
Lu H; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; The Russell H. Morgan Department of Radiology & Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, Maryland, USA.
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Źródło :
Magnetic resonance in medicine [Magn Reson Med] 2021 Jul; Vol. 86 (1), pp. 143-156. Date of Electronic Publication: 2021 Feb 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Blood-Brain Barrier*/diagnostic imaging
Water*/analysis
Germany ; Magnetic Resonance Imaging ; Netherlands ; Permeability ; Reproducibility of Results
Czasopismo naukowe
Tytuł :
Emerging pathogenic role of peripheral blood factors following BBB disruption in neurodegenerative disease.
Autorzy :
Jeon MT; Korea Brain Research Institute (KBRI), 61, Cheomdan-ro, Dong-gu, Daegu, 41062, Republic of Korea.
Kim KS; Korea Brain Research Institute (KBRI), 61, Cheomdan-ro, Dong-gu, Daegu, 41062, Republic of Korea; Department of Brain and Cognitive Sciences, Daegu Gyeongbuk Institute of Science & Technology (DGIST), 333, Techno jungang-daero, Hyeonpung-eup, Dalseong-gun, Daegu, 42988, Republic of Korea.
Kim ES; Korea Brain Research Institute (KBRI), 61, Cheomdan-ro, Dong-gu, Daegu, 41062, Republic of Korea; Department of Brain and Cognitive Sciences, Daegu Gyeongbuk Institute of Science & Technology (DGIST), 333, Techno jungang-daero, Hyeonpung-eup, Dalseong-gun, Daegu, 42988, Republic of Korea.
Lee S; Korea Brain Research Institute (KBRI), 61, Cheomdan-ro, Dong-gu, Daegu, 41062, Republic of Korea; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, 16 De Crespigny Park, London, SE5 8AF, UK.
Kim J; Korea Brain Research Institute (KBRI), 61, Cheomdan-ro, Dong-gu, Daegu, 41062, Republic of Korea.
Hoe HS; Korea Brain Research Institute (KBRI), 61, Cheomdan-ro, Dong-gu, Daegu, 41062, Republic of Korea; Department of Brain and Cognitive Sciences, Daegu Gyeongbuk Institute of Science & Technology (DGIST), 333, Techno jungang-daero, Hyeonpung-eup, Dalseong-gun, Daegu, 42988, Republic of Korea. Electronic address: .
Kim DG; Korea Brain Research Institute (KBRI), 61, Cheomdan-ro, Dong-gu, Daegu, 41062, Republic of Korea. Electronic address: .
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Źródło :
Ageing research reviews [Ageing Res Rev] 2021 Jul; Vol. 68, pp. 101333. Date of Electronic Publication: 2021 Mar 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Blood-Brain Barrier*
Neurodegenerative Diseases*
Brain ; Central Nervous System ; Humans ; Neuroglia
Czasopismo naukowe
Tytuł :
High-fat diet exacerbates lead-induced blood-brain barrier disruption by disrupting tight junction integrity.
Autorzy :
Li C; School of Public Health, North China University of Science and Technology, Tangshan, Hebei, China.; Shandong Academy of Occupational Health and Occupational Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji'nan, Shandong, China.
Shi L; Biomedical Sciences College & Shandong Medicinal Biotechnology Centre, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji'nan, Shandong, China.
Wang Y; Institute of Plastic Surgery, Weifang Medical University, Weifang, Shandong, China.
Peng C; Shandong Academy of Occupational Health and Occupational Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji'nan, Shandong, China.; Queensland Alliance for Environmental Health Sciences (QAEHS), The University of Queensland, Brisbane, Queensland, Australia.
Wu L; School of Public Health, North China University of Science and Technology, Tangshan, Hebei, China.
Zhang Y; School of Public Health, North China University of Science and Technology, Tangshan, Hebei, China.; Laboratory Animal Center, North China University of Science and Technology, Tangshan, Hebei, China.
Du Z; Shandong Academy of Occupational Health and Occupational Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji'nan, Shandong, China.
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Źródło :
Environmental toxicology [Environ Toxicol] 2021 Jul; Vol. 36 (7), pp. 1412-1421. Date of Electronic Publication: 2021 Mar 21.
Typ publikacji :
Journal Article
MeSH Terms :
Blood-Brain Barrier*/metabolism
Tight Junctions*/metabolism
Diet, High-Fat/adverse effects ; Humans ; Lead/toxicity ; Occludin/metabolism
Czasopismo naukowe
Tytuł :
Comparing the Pfizer Central Nervous System Multiparameter Optimization Calculator and a BBB Machine Learning Model.
Autorzy :
Urbina F; Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7545, United States.; Collaborations Pharmaceuticals, Inc., 840 Main Campus Drive, Lab 3510, Raleigh, North Carolina 27606, United States.
Zorn KM; Collaborations Pharmaceuticals, Inc., 840 Main Campus Drive, Lab 3510, Raleigh, North Carolina 27606, United States.
Brunner D; PsychoGenics, 215 College Road, Paramus, New Jersey 07652, United States.
Ekins S; Collaborations Pharmaceuticals, Inc., 840 Main Campus Drive, Lab 3510, Raleigh, North Carolina 27606, United States.
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Źródło :
ACS chemical neuroscience [ACS Chem Neurosci] 2021 Jun 16; Vol. 12 (12), pp. 2247-2253. Date of Electronic Publication: 2021 May 24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Blood-Brain Barrier*
Central Nervous System*
Bayes Theorem ; Central Nervous System Agents ; Machine Learning
Czasopismo naukowe
Tytuł :
Blood-Brain Barrier Breakdown in Stress and Neurodegeneration: Biochemical Mechanisms and New Models for Translational Research.
Autorzy :
Salmina AB; Division of Brain Sciences, Research Center of Neurology, Moscow, 125367, Russia. .; Research Institute of Molecular Medicine and Pathobiochemistry, Prof. V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, 660022, Russia.
Komleva YK; Research Institute of Molecular Medicine and Pathobiochemistry, Prof. V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, 660022, Russia.
Malinovskaya NA; Research Institute of Molecular Medicine and Pathobiochemistry, Prof. V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, 660022, Russia.
Morgun AV; Research Institute of Molecular Medicine and Pathobiochemistry, Prof. V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, 660022, Russia.
Teplyashina EA; Research Institute of Molecular Medicine and Pathobiochemistry, Prof. V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, 660022, Russia.
Lopatina OL; Research Institute of Molecular Medicine and Pathobiochemistry, Prof. V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, 660022, Russia.
Gorina YV; Research Institute of Molecular Medicine and Pathobiochemistry, Prof. V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, 660022, Russia.
Kharitonova EV; Research Institute of Molecular Medicine and Pathobiochemistry, Prof. V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, 660022, Russia.
Khilazheva ED; Research Institute of Molecular Medicine and Pathobiochemistry, Prof. V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, 660022, Russia.
Shuvaev AN; Research Institute of Molecular Medicine and Pathobiochemistry, Prof. V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, 660022, Russia.
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Źródło :
Biochemistry. Biokhimiia [Biochemistry (Mosc)] 2021 Jun; Vol. 86 (6), pp. 746-760.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Blood-Brain Barrier/*physiopathology
Neurodegenerative Diseases/*physiopathology
Stress, Psychological/*physiopathology
Blood-Brain Barrier/metabolism ; Humans ; Neurodegenerative Diseases/metabolism ; Stress, Psychological/metabolism
Czasopismo naukowe
Tytuł :
Measuring Xe transfer across the blood-brain barrier using MR spectroscopy.
Autorzy :
Rao MR; POLARIS, Department of Infection, Immunity and Cardiovascular Disease and Insigneo Institute of In-silico Medicine, University of Sheffield, Sheffield, UK.
Norquay G; POLARIS, Department of Infection, Immunity and Cardiovascular Disease and Insigneo Institute of In-silico Medicine, University of Sheffield, Sheffield, UK.
Stewart NJ; POLARIS, Department of Infection, Immunity and Cardiovascular Disease and Insigneo Institute of In-silico Medicine, University of Sheffield, Sheffield, UK.
Wild JM; POLARIS, Department of Infection, Immunity and Cardiovascular Disease and Insigneo Institute of In-silico Medicine, University of Sheffield, Sheffield, UK.
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Źródło :
Magnetic resonance in medicine [Magn Reson Med] 2021 Jun; Vol. 85 (6), pp. 2939-2949. Date of Electronic Publication: 2021 Jan 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Blood-Brain Barrier*/diagnostic imaging
Xenon Isotopes*
Humans ; Lung ; Magnetic Resonance Imaging ; Magnetic Resonance Spectroscopy ; Xenon
Czasopismo naukowe
Tytuł :
Targeting receptor-ligand chemistry for drug delivery across blood-brain barrier in brain diseases.
Autorzy :
Anthony DP; Department of Biotechnology, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal 576104, Karnataka, India.
Hegde M; Department of Radiation Biology & Toxicology, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal 576104, Karnataka, India.
Shetty SS; Department of Biotechnology, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal 576104, Karnataka, India.
Rafic T; Department of Biotechnology, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal 576104, Karnataka, India.
Mutalik S; Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal 576104, Karnataka, India.
Rao BSS; Department of Radiation Biology & Toxicology, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal 576104, Karnataka, India. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Jun 01; Vol. 274, pp. 119326. Date of Electronic Publication: 2021 Mar 09.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Drug Delivery Systems*
Blood-Brain Barrier/*drug effects
Brain Diseases/*drug therapy
Central Nervous System Agents/*administration & dosage
Drug Carriers/*chemistry
Receptors, Cell Surface/*metabolism
Animals ; Biological Transport ; Blood-Brain Barrier/metabolism ; Brain Diseases/metabolism ; Brain Diseases/pathology ; Humans ; Ligands ; Permeability
Czasopismo naukowe
Tytuł :
Small Interfering RNA Targeting DMP1 Protects Mice Against Blood-Brain Barrier Disruption and Brain Injury After Intracerebral Hemorrhage.
Autorzy :
Shu Y; Department of Anatomy, Basic Medical College, Chongqing Medical University, Chongqing 400016, China; Institute of Neuroscience, Chongqing Medical University, Chongqing 400016, China. Electronic address: .
Huang J; Department of Anatomy, Basic Medical College, Chongqing Medical University, Chongqing 400016, China; Institute of Neuroscience, Chongqing Medical University, Chongqing 400016, China. Electronic address: .
Gao M; Department of Clinical Laboratory, 521 Hospital of Ordnance Industry, Xi'an 7100065, China. Electronic address: .
Gan S; Department of Anatomy, Basic Medical College, Chongqing Medical University, Chongqing 400016, China; Institute of Neuroscience, Chongqing Medical University, Chongqing 400016, China. Electronic address: .
Zhu S; Department of Anatomy, Basic Medical College, Chongqing Medical University, Chongqing 400016, China; Institute of Neuroscience, Chongqing Medical University, Chongqing 400016, China. Electronic address: .
Xu S; Department of Anatomy, Basic Medical College, Chongqing Medical University, Chongqing 400016, China; Institute of Neuroscience, Chongqing Medical University, Chongqing 400016, China. Electronic address: .
Yang Z; Department of Anatomy, Basic Medical College, Chongqing Medical University, Chongqing 400016, China; Institute of Neuroscience, Chongqing Medical University, Chongqing 400016, China. Electronic address: .
Liao Y; Department of Anatomy, Basic Medical College, Chongqing Medical University, Chongqing 400016, China; Institute of Neuroscience, Chongqing Medical University, Chongqing 400016, China. Electronic address: .
Lu W; Department of Anatomy, Basic Medical College, Chongqing Medical University, Chongqing 400016, China; Institute of Neuroscience, Chongqing Medical University, Chongqing 400016, China. Electronic address: .
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Źródło :
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association [J Stroke Cerebrovasc Dis] 2021 Jun; Vol. 30 (6), pp. 105760. Date of Electronic Publication: 2021 Apr 09.
Typ publikacji :
Journal Article
MeSH Terms :
RNA Interference*
Blood-Brain Barrier/*metabolism
Brain Edema/*prevention & control
Cerebral Hemorrhage/*therapy
Extracellular Matrix Proteins/*metabolism
RNA, Small Interfering/*metabolism
Animals ; Blood-Brain Barrier/ultrastructure ; Brain Edema/genetics ; Brain Edema/metabolism ; Brain Edema/pathology ; Cerebral Hemorrhage/genetics ; Cerebral Hemorrhage/metabolism ; Cerebral Hemorrhage/pathology ; Disease Models, Animal ; Extracellular Matrix Proteins/genetics ; Male ; Matrix Metalloproteinase 9/genetics ; Matrix Metalloproteinase 9/metabolism ; Mice ; Occludin/genetics ; Occludin/metabolism ; RNA, Small Interfering/genetics ; Zonula Occludens-1 Protein/genetics ; Zonula Occludens-1 Protein/metabolism
Czasopismo naukowe
Tytuł :
Rac1/Wave2/Arp3 Pathway Mediates Rat Blood-Brain Barrier Dysfunction under Simulated Microgravity Based on Proteomics Strategy.
Autorzy :
Yan R; School of Life Science, Beijing Institute of Technology, No. 5 Zhongguancun South Street, Haidian District, Beijing 100081, China.
Liu H; School of Life Science, Beijing Institute of Technology, No. 5 Zhongguancun South Street, Haidian District, Beijing 100081, China.
Lv F; School of Life Science, Beijing Institute of Technology, No. 5 Zhongguancun South Street, Haidian District, Beijing 100081, China.
Deng Y; School of Life Science, Beijing Institute of Technology, No. 5 Zhongguancun South Street, Haidian District, Beijing 100081, China.
Li Y; School of Life Science, Beijing Institute of Technology, No. 5 Zhongguancun South Street, Haidian District, Beijing 100081, China.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 May 13; Vol. 22 (10). Date of Electronic Publication: 2021 May 13.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation*
Actin-Related Protein 3/*metabolism
Blood-Brain Barrier/*pathology
Proteome/*metabolism
Weightlessness Simulation/*adverse effects
Wiskott-Aldrich Syndrome Protein Family/*metabolism
rac1 GTP-Binding Protein/*metabolism
Actin Cytoskeleton ; Animals ; Blood-Brain Barrier/metabolism ; Male ; Proteome/analysis ; Rats ; Rats, Sprague-Dawley ; Signal Transduction ; Tight Junctions
Czasopismo naukowe
Tytuł :
BBB-crossing adeno-associated virus vector: An excellent gene delivery tool for CNS disease treatment.
Autorzy :
Chen W; Center for Pituitary Tumor Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Yao S; Center for Pituitary Tumor Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Wan J; Department of Immunology, Jiangsu University, Zhenjiang 212013, China; Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address: .
Tian Y; Department of Immunology, Jiangsu University, Zhenjiang 212013, China.
Huang L; Department of Immunology, Jiangsu University, Zhenjiang 212013, China.
Wang S; Department of TCM, Yangzhou Traditional Chinese Medical Hospital, Yangzhou 225600, China.
Akter F; Faculty of Arts and Sciences, Harvard University, Cambridge, MA, USA; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.
Wu Y; Department of Immunology, Jiangsu University, Zhenjiang 212013, China; School of Medicine, Yangzhou University, Yangzhou 225600, China; Department of Nuclear Medicine, Yangzhou Traditional Chinese Medical Hospital, Yangzhou 225600, China.
Yao Y; Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address: .
Zhang X; School of Medicine, Yangzhou University, Yangzhou 225600, China; Department of Oncology, Yangzhou Traditional Chinese Medical Hospital, Yangzhou 225600, China. Electronic address: .
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Źródło :
Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2021 May 10; Vol. 333, pp. 129-138. Date of Electronic Publication: 2021 Mar 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Blood-Brain Barrier*
Central Nervous System Diseases*/therapy
Dependovirus/genetics ; Gene Transfer Techniques ; Genetic Therapy ; Humans
Czasopismo naukowe
Tytuł :
Blood-brain barrier permeability imaging as a predictor for delayed cerebral ischaemia following subarachnoid haemorrhage. A narrative review.
Autorzy :
Amoo M; National Center for Neurosurgery, Beaumont Hospital, Dublin 9, Ireland. .; Royal College of Surgeons in Ireland, Dublin, Ireland. .
Henry J; School of Medicine, University College Dublin, Belfield, Dublin 4, Ireland.
Pender N; Royal College of Surgeons in Ireland, Dublin, Ireland.; Department of Clinical Neuropsychology, Beaumont Hospital, Dublin 9, Ireland.; Department of Academic Neurology, Trinity College Dublin, Dublin, Ireland.
Brennan P; Royal College of Surgeons in Ireland, Dublin, Ireland.; Department of Radiology, Beaumont Hospital, Dublin 9, Ireland.
Campbell M; Department of Genetics, Trinity College Dublin, Dublin, Ireland.
Javadpour M; National Center for Neurosurgery, Beaumont Hospital, Dublin 9, Ireland.; Royal College of Surgeons in Ireland, Dublin, Ireland.; Department of Academic Neurology, Trinity College Dublin, Dublin, Ireland.
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Źródło :
Acta neurochirurgica [Acta Neurochir (Wien)] 2021 May; Vol. 163 (5), pp. 1457-1467. Date of Electronic Publication: 2021 Jan 06.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Capillary Permeability*
Blood-Brain Barrier/*metabolism
Brain Ischemia/*etiology
Subarachnoid Hemorrhage/*complications
Blood-Brain Barrier/pathology ; Humans
Czasopismo naukowe
Tytuł :
Combining T 2 measurements and crusher gradients into a single ASL sequence for comparison of the measurement of water transport across the blood-brain barrier.
Autorzy :
Petitclerc L; Gorter Center for High-Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands.; Leiden Institute for Brain and Cognition, Leiden, Netherlands.
Schmid S; Gorter Center for High-Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands.; Leiden Institute for Brain and Cognition, Leiden, Netherlands.
Hirschler L; Gorter Center for High-Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands.
van Osch MJP; Gorter Center for High-Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands.; Leiden Institute for Brain and Cognition, Leiden, Netherlands.
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Źródło :
Magnetic resonance in medicine [Magn Reson Med] 2021 May; Vol. 85 (5), pp. 2649-2660. Date of Electronic Publication: 2020 Nov 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Blood-Brain Barrier*/diagnostic imaging
Brain*
Cerebrovascular Circulation ; Humans ; Magnetic Resonance Imaging ; Spin Labels ; Water
Czasopismo naukowe
Tytuł :
SARS-CoV-2 journey to the brain with a focus on potential role of docosahexaenoic acid bioactive lipid mediators.
Autorzy :
Hachem M; Khalifa University, Department of Chemistry, Abu Dhabi, United Arab Emirates. Electronic address: .
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Źródło :
Biochimie [Biochimie] 2021 May; Vol. 184, pp. 95-103. Date of Electronic Publication: 2021 Feb 25.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Blood-Brain Barrier/*virology
COVID-19/*complications
Central Nervous System Diseases/*virology
Docosahexaenoic Acids/*metabolism
SARS-CoV-2/*metabolism
Anti-Inflammatory Agents/metabolism ; Anti-Inflammatory Agents/therapeutic use ; Blood-Brain Barrier/metabolism ; Brain/virology ; COVID-19/drug therapy ; COVID-19/metabolism ; Central Nervous System Diseases/metabolism ; Docosahexaenoic Acids/therapeutic use ; Flaviviridae/metabolism ; Humans ; Lipid Metabolism ; Neuroprotective Agents/metabolism ; Neuroprotective Agents/therapeutic use
Czasopismo naukowe
Tytuł :
2-(2-Cholesteroxyethoxyl)ethyl 3'-S-glutathionylpropionate and its self-assembled micelles for brain delivery: Design, synthesis and evaluation.
Autorzy :
Najmi A; Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, Box 2202C, South Dakota State University, Brookings, SD 57007, United States.
Wang S; Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, Box 2202C, South Dakota State University, Brookings, SD 57007, United States.
Huang Y; Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, Box 2202C, South Dakota State University, Brookings, SD 57007, United States.
Seefeldt T; Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, Box 2202C, South Dakota State University, Brookings, SD 57007, United States.
Alqahtani Y; Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, Box 2202C, South Dakota State University, Brookings, SD 57007, United States.
Guan X; Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, Box 2202C, South Dakota State University, Brookings, SD 57007, United States. Electronic address: .
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Źródło :
International journal of pharmaceutics [Int J Pharm] 2021 May 01; Vol. 600, pp. 120520. Date of Electronic Publication: 2021 Mar 26.
Typ publikacji :
Journal Article
MeSH Terms :
Blood-Brain Barrier*
Micelles*
Animals ; Biological Transport ; Brain ; Drug Delivery Systems ; Mice
Czasopismo naukowe
Tytuł :
Optimizing blood-brain barrier permeation through deep reinforcement learning for de novo drug design.
Autorzy :
Pereira T; CSUC/DEI, University of Coimbra, Coimbra 3030-290, Portugal.; IEETA/DETI, University of Aveiro, Aveiro 3810-193, Portugal.
Abbasi M; CSUC/DEI, University of Coimbra, Coimbra 3030-290, Portugal.
Oliveira JL; IEETA/DETI, University of Aveiro, Aveiro 3810-193, Portugal.
Ribeiro B; CSUC/DEI, University of Coimbra, Coimbra 3030-290, Portugal.
Arrais J; CSUC/DEI, University of Coimbra, Coimbra 3030-290, Portugal.
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Źródło :
Bioinformatics (Oxford, England) [Bioinformatics] 2021 Jul 12; Vol. 37 (Suppl_1), pp. i84-i92.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Blood-Brain Barrier*
Drug Design*
Biological Transport ; Neural Networks, Computer
Czasopismo naukowe

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