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Wyszukujesz frazę ""BRCA2 Protein"" wg kryterium: Temat


Tytuł :
Conformational flexibility and oligomerization of BRCA2 regions induced by RAD51 interaction.
Autorzy :
Sidhu A; Department of Molecular Genetics, Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands.; Department of Radiation Oncology and Cancer Genomics Center, Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands.
Grosbart M; Department of Molecular Genetics, Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands.
Sánchez H; Department of Bionanoscience, Kavli Institute of Nanoscience, Faculty of Applied Sciences, Delft University of Technology, 2628 CJ Delft, The Netherlands.
Verhagen B; Department of Molecular Genetics, Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands.
van der Zon NLL; Department of Molecular Genetics, Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands.
Ristić D; Department of Molecular Genetics, Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands.
van Rossum-Fikkert SE; Department of Molecular Genetics, Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands.
Wyman C; Department of Molecular Genetics, Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands.; Department of Radiation Oncology and Cancer Genomics Center, Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Sep 25; Vol. 48 (17), pp. 9649-9659.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
BRCA2 Protein/*chemistry
BRCA2 Protein/*metabolism
Rad51 Recombinase/*metabolism
BRCA2 Protein/genetics ; Humans ; Microscopy, Atomic Force ; Mutation, Missense ; Protein Conformation ; Protein Interaction Domains and Motifs ; Protein Multimerization ; Rad51 Recombinase/genetics
Czasopismo naukowe
Tytuł :
PCAF-Mediated Histone Acetylation Promotes Replication Fork Degradation by MRE11 and EXO1 in BRCA-Deficient Cells.
Autorzy :
Kim JJ; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.
Lee SY; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.
Choi JH; Department of Physiology, Ajou University School of Medicine, Suwon 16499, Republic of Korea.
Woo HG; Department of Physiology, Ajou University School of Medicine, Suwon 16499, Republic of Korea; Department of Biomedical Science, Graduate School, Ajou University, Suwon 16499, Republic of Korea.
Xhemalce B; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA; Livestrong Cancer Institutes, Dell Medical School, The University of Texas at Austin, Austin, TX 78712, USA.
Miller KM; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA; Livestrong Cancer Institutes, Dell Medical School, The University of Texas at Austin, Austin, TX 78712, USA. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2020 Oct 15; Vol. 80 (2), pp. 327-344.e8. Date of Electronic Publication: 2020 Sep 22.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
DNA Replication*/drug effects
BRCA1 Protein/*deficiency
BRCA2 Protein/*deficiency
DNA Repair Enzymes/*metabolism
Exodeoxyribonucleases/*metabolism
Histones/*metabolism
MRE11 Homologue Protein/*metabolism
p300-CBP Transcription Factors/*metabolism
Acetylation/drug effects ; Amino Acid Sequence ; Ataxia Telangiectasia Mutated Proteins/metabolism ; BRCA1 Protein/metabolism ; BRCA2 Protein/metabolism ; Breast Neoplasms/genetics ; Cell Line, Tumor ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Lysine/metabolism ; Models, Biological ; Mutation/genetics ; Phosphorylation/drug effects ; Phosphoserine/metabolism ; Poly(ADP-ribose) Polymerase Inhibitors/pharmacology ; Protein Binding/drug effects ; p300-CBP Transcription Factors/chemistry ; p300-CBP Transcription Factors/genetics
Czasopismo naukowe
Tytuł :
STAT3 imparts BRCAness by impairing homologous recombination repair in Epstein-Barr virus-transformed B lymphocytes.
Autorzy :
McIntosh MT; Child Health Research Institute, Department of Pediatrics, University of Florida, Gainesville, FL, United States of America.; Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL, United States of America.
Koganti S; Division of Infectious Diseases, Department of Pediatrics, Stony Brook University, Stony Brook, NY, United States of America.
Boatwright JL; Bioinformatics Core Facility, University of Florida, Gainesville, FL, United States of America.
Li X; Division of Infectious Diseases, Department of Pediatrics, University of Florida, Gainesville, FL, United States of America.
Spadaro SV; Division of Infectious Diseases, Department of Pediatrics, Stony Brook University, Stony Brook, NY, United States of America.
Brantly AC; Division of Infectious Diseases, Department of Pediatrics, University of Florida, Gainesville, FL, United States of America.
Ayers JB; Division of Infectious Diseases, Department of Pediatrics, Stony Brook University, Stony Brook, NY, United States of America.
Perez RD; Department of Microbiology and Immunology, Stony Brook University, Stony Brook, NY, United States of America.
Burton EM; Division of Infectious Diseases, Department of Pediatrics, University of Florida, Gainesville, FL, United States of America.
Burgula S; Division of Infectious Diseases, Department of Pediatrics, Stony Brook University, Stony Brook, NY, United States of America.
MacCarthy T; Laufer Center for Physical and Quantitative Biology, Stony Brook University, Stony Brook, NY, United States of America.
Bhaduri-McIntosh S; Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL, United States of America.; Division of Infectious Diseases, Department of Pediatrics, University of Florida, Gainesville, FL, United States of America.
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Źródło :
PLoS pathogens [PLoS Pathog] 2020 Oct 01; Vol. 16 (10), pp. e1008849. Date of Electronic Publication: 2020 Oct 01 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Breaks, Double-Stranded*
Recombinational DNA Repair*
B-Lymphocytes/*virology
BRCA1 Protein/*metabolism
BRCA2 Protein/*metabolism
Epstein-Barr Virus Infections/*virology
STAT3 Transcription Factor/*metabolism
Adolescent ; Adult ; B-Lymphocytes/cytology ; B-Lymphocytes/metabolism ; BRCA1 Protein/genetics ; BRCA2 Protein/genetics ; Burkitt Lymphoma/genetics ; Burkitt Lymphoma/pathology ; Burkitt Lymphoma/virology ; Cell Proliferation ; DNA End-Joining Repair ; Epstein-Barr Virus Infections/genetics ; Epstein-Barr Virus Infections/metabolism ; Herpesvirus 4, Human/isolation & purification ; Humans ; Neoplasms/genetics ; Neoplasms/pathology ; Neoplasms/virology ; Phosphorylation ; STAT3 Transcription Factor/genetics ; Young Adult
Czasopismo naukowe
Tytuł :
Bypass of premature stop codons and generation of functional BRCA2 by exon skipping.
Autorzy :
Stauffer S; Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Frederick, MD, 21702, USA.
Biswas K; Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Frederick, MD, 21702, USA.
Sharan SK; Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Frederick, MD, 21702, USA. .
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Źródło :
Journal of human genetics [J Hum Genet] 2020 Sep; Vol. 65 (9), pp. 805-809. Date of Electronic Publication: 2020 May 11.
Typ publikacji :
Journal Article
MeSH Terms :
Codon, Nonsense*/genetics
BRCA2 Protein/*genetics
Embryonic Stem Cells/*metabolism
Ovarian Neoplasms/*genetics
Alternative Splicing ; Animals ; BRCA2 Protein/metabolism ; Cell Survival/genetics ; Exons ; Female ; Gene Knockout Techniques ; Mice ; Mice, Knockout ; Mutation ; RNA Splice Sites
Czasopismo naukowe
Tytuł :
DSS1 and ssDNA regulate oligomerization of BRCA2.
Autorzy :
Le HP; Department of Microbiology and Molecular Genetics, University of California, Davis, Davis, CA 95616-8665, USA.
Ma X; Department of Microbiology and Molecular Genetics, University of California, Davis, Davis, CA 95616-8665, USA.
Vaquero J; Department of Microbiology and Molecular Genetics, University of California, Davis, Davis, CA 95616-8665, USA.
Brinkmeyer M; Department of Microbiology and Molecular Genetics, University of California, Davis, Davis, CA 95616-8665, USA.
Guo F; Department of Molecular and Cellular Biology, University of California, Davis, Davis, CA 95616-8665, USA.
Heyer WD; Department of Microbiology and Molecular Genetics, University of California, Davis, Davis, CA 95616-8665, USA.; Department of Molecular and Cellular Biology, University of California, Davis, Davis, CA 95616-8665, USA.
Liu J; Department of Microbiology and Molecular Genetics, University of California, Davis, Davis, CA 95616-8665, USA.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Aug 20; Vol. 48 (14), pp. 7818-7833.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
BRCA2 Protein/*metabolism
DNA, Single-Stranded/*metabolism
Proteasome Endopeptidase Complex/*metabolism
Animals ; BRCA2 Protein/chemistry ; BRCA2 Protein/genetics ; BRCA2 Protein/ultrastructure ; Cell Line ; Cricetulus ; Humans ; Protein Multimerization
Czasopismo naukowe
Tytuł :
Symmetric neural progenitor divisions require chromatin-mediated homologous recombination DNA repair by Ino80.
Autorzy :
Keil JM; Michigan Neuroscience Institute (MNI), University of Michigan, Ann Arbor, MI, 48109, USA.; Department of Human Genetics, University of Michigan, Ann Arbor, MI, 48109, USA.; Medical Scientist Training Program, University of Michigan, Ann Arbor, MI, 48109, USA.
Doyle DZ; Michigan Neuroscience Institute (MNI), University of Michigan, Ann Arbor, MI, 48109, USA.; Department of Human Genetics, University of Michigan, Ann Arbor, MI, 48109, USA.; Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI, 48109, USA.
Qalieh A; Michigan Neuroscience Institute (MNI), University of Michigan, Ann Arbor, MI, 48109, USA.; Department of Human Genetics, University of Michigan, Ann Arbor, MI, 48109, USA.
Lam MM; Michigan Neuroscience Institute (MNI), University of Michigan, Ann Arbor, MI, 48109, USA.; Department of Human Genetics, University of Michigan, Ann Arbor, MI, 48109, USA.
Funk OH; Michigan Neuroscience Institute (MNI), University of Michigan, Ann Arbor, MI, 48109, USA.; Department of Human Genetics, University of Michigan, Ann Arbor, MI, 48109, USA.
Qalieh Y; Michigan Neuroscience Institute (MNI), University of Michigan, Ann Arbor, MI, 48109, USA.; Department of Human Genetics, University of Michigan, Ann Arbor, MI, 48109, USA.
Shi L; Michigan Neuroscience Institute (MNI), University of Michigan, Ann Arbor, MI, 48109, USA.; Department of Human Genetics, University of Michigan, Ann Arbor, MI, 48109, USA.
Mohan N; Michigan Neuroscience Institute (MNI), University of Michigan, Ann Arbor, MI, 48109, USA.; Department of Human Genetics, University of Michigan, Ann Arbor, MI, 48109, USA.
Sorel A; Michigan Neuroscience Institute (MNI), University of Michigan, Ann Arbor, MI, 48109, USA.; Department of Human Genetics, University of Michigan, Ann Arbor, MI, 48109, USA.
Kwan KY; Michigan Neuroscience Institute (MNI), University of Michigan, Ann Arbor, MI, 48109, USA. .; Department of Human Genetics, University of Michigan, Ann Arbor, MI, 48109, USA. .; Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI, 48109, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Jul 31; Vol. 11 (1), pp. 3839. Date of Electronic Publication: 2020 Jul 31.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Recombinational DNA Repair*
ATPases Associated with Diverse Cellular Activities/*genetics
BRCA2 Protein/*genetics
Chromatin/*chemistry
DNA-Binding Proteins/*genetics
Neural Stem Cells/*metabolism
Neurogenesis/*genetics
ATPases Associated with Diverse Cellular Activities/deficiency ; Animals ; Apoptosis/genetics ; BRCA2 Protein/deficiency ; Cell Division ; Chromatin/metabolism ; Chromatin Assembly and Disassembly ; DNA/genetics ; DNA/metabolism ; DNA Breaks, Double-Stranded ; DNA-Binding Proteins/deficiency ; Embryo, Mammalian ; Gene Expression Regulation, Developmental ; Mice ; Mice, Transgenic ; Neocortex/cytology ; Neocortex/growth & development ; Neocortex/metabolism ; Neural Stem Cells/cytology ; Signal Transduction ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism ; YY1 Transcription Factor/genetics ; YY1 Transcription Factor/metabolism
Czasopismo naukowe
Tytuł :
Complex Characterization of Germline Large Genomic Rearrangements of the BRCA1 and BRCA2 Genes in High-Risk Breast Cancer Patients-Novel Variants from a Large National Center.
Autorzy :
Bozsik A; National Institute of Oncology, Department of Molecular Genetics, H-1122 Budapest, Ráth György utca 7-9, Hungary.; Hereditary Cancers Research Group, H-1089 Budapest, Nagyvárad tér 4, Hungary.
Pócza T; National Institute of Oncology, Department of Molecular Genetics, H-1122 Budapest, Ráth György utca 7-9, Hungary.
Papp J; National Institute of Oncology, Department of Molecular Genetics, H-1122 Budapest, Ráth György utca 7-9, Hungary.; Hereditary Cancers Research Group, H-1089 Budapest, Nagyvárad tér 4, Hungary.
Vaszkó T; National Institute of Oncology, Department of Molecular Genetics, H-1122 Budapest, Ráth György utca 7-9, Hungary.
Butz H; National Institute of Oncology, Department of Molecular Genetics, H-1122 Budapest, Ráth György utca 7-9, Hungary.; Hereditary Cancers Research Group, H-1089 Budapest, Nagyvárad tér 4, Hungary.; Semmelweis University, Department of Laboratory Medicine, H-1089 Budapest, Nagyvárad tér 4, Hungary.
Patócs A; National Institute of Oncology, Department of Molecular Genetics, H-1122 Budapest, Ráth György utca 7-9, Hungary.; Hereditary Cancers Research Group, H-1089 Budapest, Nagyvárad tér 4, Hungary.; Semmelweis University, Department of Laboratory Medicine, H-1089 Budapest, Nagyvárad tér 4, Hungary.
Oláh E; National Institute of Oncology, Department of Molecular Genetics, H-1122 Budapest, Ráth György utca 7-9, Hungary.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Jun 30; Vol. 21 (13). Date of Electronic Publication: 2020 Jun 30.
Typ publikacji :
Journal Article
MeSH Terms :
BRCA1 Protein/*genetics
BRCA2 Protein/*genetics
Breast Neoplasms/*genetics
Adult ; BRCA1 Protein/metabolism ; BRCA2 Protein/metabolism ; Breast Neoplasms/metabolism ; Exons/genetics ; Female ; Gene Rearrangement/genetics ; Genes, BRCA1 ; Genes, BRCA2 ; Genetic Predisposition to Disease/genetics ; Genomics/methods ; Germ Cells ; Germ-Line Mutation/genetics ; Humans ; Hungary/epidemiology ; Middle Aged ; Mutation/genetics ; Pedigree ; Risk Factors ; Sequence Deletion
Czasopismo naukowe
Tytuł :
Endogenous DNA 3' Blocks Are Vulnerabilities for BRCA1 and BRCA2 Deficiency and Are Reversed by the APE2 Nuclease.
Autorzy :
Álvarez-Quilón A; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada.
Wojtaszek JL; Structural Cell Biology Group, Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA.
Mathieu MC; Repare Therapeutics, 7210 Frederick-Banting, Suite 100, St-Laurent, QC H4S 2A1, Canada.
Patel T; Structural Cell Biology Group, Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA.
Appel CD; Structural Cell Biology Group, Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA.
Hustedt N; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada.
Rossi SE; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada.
Wallace BD; Structural Cell Biology Group, Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA.
Setiaputra D; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada.
Adam S; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada.
Ohashi Y; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada.
Melo H; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada.
Cho T; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada; Department of Molecular Genetics, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada.
Gervais C; National Research Council Canada Human Health Therapeutics Research Center, 6100 Royalmount Avenue, Montreal, QC H4P 2R2, Canada.
Muñoz IM; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.
Grazzini E; National Research Council Canada Human Health Therapeutics Research Center, 6100 Royalmount Avenue, Montreal, QC H4P 2R2, Canada.
Young JTF; Repare Therapeutics, 7210 Frederick-Banting, Suite 100, St-Laurent, QC H4S 2A1, Canada.
Rouse J; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.
Zinda M; Repare Therapeutics, 7210 Frederick-Banting, Suite 100, St-Laurent, QC H4S 2A1, Canada.
Williams RS; Structural Cell Biology Group, Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA. Electronic address: .
Durocher D; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada; Department of Molecular Genetics, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2020 Jun 18; Vol. 78 (6), pp. 1152-1165.e8. Date of Electronic Publication: 2020 Jun 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
BRCA1 Protein/*metabolism
BRCA2 Protein/*metabolism
DNA-(Apurinic or Apyrimidinic Site) Lyase/*metabolism
Endonucleases/*metabolism
Multifunctional Enzymes/*metabolism
BRCA1 Protein/genetics ; BRCA2 Protein/genetics ; Cell Line ; DNA/metabolism ; DNA Damage ; DNA Repair/genetics ; DNA-(Apurinic or Apyrimidinic Site) Lyase/genetics ; Endonucleases/genetics ; Genes, BRCA1/physiology ; Humans ; Multifunctional Enzymes/genetics ; Phosphoric Diester Hydrolases/genetics ; Phosphoric Diester Hydrolases/metabolism
Czasopismo naukowe
Tytuł :
Spontaneous Development of Hepatocellular Carcinoma and B-Cell Lymphoma in Mosaic and Heterozygous Brca2 and Cdkn1a Interacting Protein Knockout Mice.
Autorzy :
Lu H; Rutgers Cancer Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, Piscataway, New Jersey; Department of Radiation Oncology, Rutgers Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, Piscataway, New Jersey.
Ye C; Rutgers Cancer Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, Piscataway, New Jersey; Department of Radiation Oncology, Rutgers Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, Piscataway, New Jersey.
Feng X; Rutgers Cancer Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, Piscataway, New Jersey; Department of Radiation Oncology, Rutgers Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, Piscataway, New Jersey.
Liu J; Rutgers Cancer Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, Piscataway, New Jersey; Department of Radiation Oncology, Rutgers Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, Piscataway, New Jersey.
Bhaumik M; Department of Pediatrics, Rutgers Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, Piscataway, New Jersey.
Xia B; Rutgers Cancer Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, Piscataway, New Jersey; Department of Radiation Oncology, Rutgers Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, Piscataway, New Jersey.
Liu C; Department of Pathology, Rutgers Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, Piscataway, New Jersey.
Shen Z; Rutgers Cancer Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, Piscataway, New Jersey; Department of Radiation Oncology, Rutgers Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, Piscataway, New Jersey. Electronic address: .
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Źródło :
The American journal of pathology [Am J Pathol] 2020 Jun; Vol. 190 (6), pp. 1175-1187. Date of Electronic Publication: 2020 Mar 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
BRCA2 Protein/*genetics
Carcinoma, Hepatocellular/*genetics
Cell Cycle Proteins/*genetics
Liver Neoplasms/*genetics
Lymphoma, B-Cell/*genetics
Animals ; BRCA2 Protein/metabolism ; Carcinoma, Hepatocellular/metabolism ; Carcinoma, Hepatocellular/pathology ; Cell Cycle Proteins/metabolism ; Heterozygote ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; Lymphoma, B-Cell/metabolism ; Lymphoma, B-Cell/pathology ; Mice ; Mice, Knockout ; Mosaicism
Czasopismo naukowe
Tytuł :
Distinct roles of BRCA2 in replication fork protection in response to hydroxyurea and DNA interstrand cross-links.
Autorzy :
Rickman KA; Laboratory of Genome Maintenance, The Rockefeller University, New York, New York 10065, USA.
Noonan RJ; Laboratory of Genome Maintenance, The Rockefeller University, New York, New York 10065, USA.
Lach FP; Laboratory of Genome Maintenance, The Rockefeller University, New York, New York 10065, USA.
Sridhar S; Laboratory of Genome Maintenance, The Rockefeller University, New York, New York 10065, USA.
Wang AT; Laboratory of Genome Maintenance, The Rockefeller University, New York, New York 10065, USA.
Abhyankar A; New York Genome Center, New York, New York 10013, USA.
Huang A; Laboratory of Genome Maintenance, The Rockefeller University, New York, New York 10065, USA.
Kelly M; Tufts Medical Center, Boston, Massachusetts 02111, USA.
Auerbach AD; Human Genetics and Hematology, The Rockefeller University, New York, New York 10065, USA.
Smogorzewska A; Laboratory of Genome Maintenance, The Rockefeller University, New York, New York 10065, USA.
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Źródło :
Genes & development [Genes Dev] 2020 Jun 01; Vol. 34 (11-12), pp. 832-846. Date of Electronic Publication: 2020 Apr 30.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
BRCA2 Protein/*metabolism
Fanconi Anemia/*genetics
Fanconi Anemia/*physiopathology
BRCA2 Protein/genetics ; Cell Line ; DNA/chemistry ; DNA Repair/drug effects ; DNA Repair/genetics ; DNA Replication/drug effects ; Homologous Recombination/genetics ; Humans ; Hydroxyurea/pharmacology ; Mutation ; Protein Domains/genetics ; Rad51 Recombinase/metabolism
Czasopismo naukowe
Tytuł :
High resolution melting profiles (HRMPs) obtained by magnetic induction cycler (MIC) have been used to monitor the BRCA2 status highlighted by next generation tumor sequencing (NGTS): a combined approach in a diagnostic environment.
Autorzy :
Mazzuccato G; Molecular and Genomic Diagnostics Unit, Fondazione Policlinico Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
De Bonis M; Molecular and Genomic Diagnostics Unit, Fondazione Policlinico Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Carboni V; Division of Oncological Gynecology, Department of Women's and Children's Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Marchetti C; Division of Oncological Gynecology, Department of Women's and Children's Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.; Catholic University of the Sacred Heart, Rome, Italy.
Urbani A; Molecular and Genomic Diagnostics Unit, Fondazione Policlinico Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy. .; Catholic University of the Sacred Heart, Rome, Italy. .
Scambia G; Division of Oncological Gynecology, Department of Women's and Children's Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.; Catholic University of the Sacred Heart, Rome, Italy.
Capoluongo E; Università Federico II-CEINGE, Biotecnologie Avanzate, Naples, Italy.
Fagotti A; Division of Oncological Gynecology, Department of Women's and Children's Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.; Catholic University of the Sacred Heart, Rome, Italy.
Minucci A; Molecular and Genomic Diagnostics Unit, Fondazione Policlinico Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy. .
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Źródło :
Molecular biology reports [Mol Biol Rep] 2020 Jun; Vol. 47 (6), pp. 4897-4903. Date of Electronic Publication: 2020 May 28.
Typ publikacji :
Journal Article
MeSH Terms :
BRCA2 Protein/*genetics
Neoplasm Recurrence, Local/*diagnosis
Nucleic Acid Denaturation/*genetics
Adult ; Alleles ; BRCA1 Protein/genetics ; BRCA1 Protein/metabolism ; BRCA2 Protein/metabolism ; Breast Neoplasms/diagnosis ; Breast Neoplasms/genetics ; DNA Mutational Analysis/methods ; Female ; Genes, BRCA1 ; Genes, BRCA2/physiology ; Germ-Line Mutation/genetics ; High-Throughput Nucleotide Sequencing/methods ; Humans ; Magnetic Phenomena ; Mutation ; Neoplasm Recurrence, Local/genetics ; Polymerase Chain Reaction/methods
Czasopismo naukowe
Tytuł :
Design, synthesis and interaction of BRC4 analogous peptides with RAD51(241-260).
Autorzy :
Li J; College of Chemical, Zhengzhou University, Zhengzhou, 450001, China.; School of Chemical Engineering and Food Science, Zhengzhou Institute of Technology, Zhengzhou, 450044, China.
Lu K; School of Chemical Engineering and Food Science, Zhengzhou Institute of Technology, Zhengzhou, 450044, China. .; School of Material and Chemical Engineering, Henan University of Engineering, Zhengzhou, 450007, China. .; College of Chemistry, Chemical and Environmental Engineering, Henan University of Technology, Locus Street, High and New Tech Industry Development Zone, Zhengzhou, 450001, China. .
Lv M; School of Material and Chemical Engineering, Henan University of Engineering, Zhengzhou, 450007, China.
Liu G; College of Chemical, Zhengzhou University, Zhengzhou, 450001, China.; School of Chemical Engineering and Food Science, Zhengzhou Institute of Technology, Zhengzhou, 450044, China.
Ma L; College of Chemistry, Chemical and Environmental Engineering, Henan University of Technology, Locus Street, High and New Tech Industry Development Zone, Zhengzhou, 450001, China.
Qi J; Shaanxi Key Laboratory of Natural Products and Chemical Biology, College of Chemistry and Pharmacy, Northwest A&F University, Yangling, 712100, China.; Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Wuhan University School of Pharmaceutical Sciences, Wuhan University, Ministry of Education, Wuhan, 430071, China.
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Źródło :
Amino acids [Amino Acids] 2020 Mar; Vol. 52 (3), pp. 361-369. Date of Electronic Publication: 2019 Dec 24.
Typ publikacji :
Journal Article
MeSH Terms :
BRCA2 Protein*/chemical synthesis
BRCA2 Protein*/chemistry
BRCA2 Protein*/genetics
Peptide Fragments*/chemical synthesis
Peptide Fragments*/chemistry
Rad51 Recombinase/*chemistry
Amino Acid Substitution ; Circular Dichroism ; Humans ; Mutation ; Protein Conformation, alpha-Helical/genetics ; Spectrometry, Fluorescence
Czasopismo naukowe
Tytuł :
Functional evaluation of five BRCA2 unclassified variants identified in a Sri Lankan cohort with inherited cancer syndromes using a mouse embryonic stem cell-based assay.
Autorzy :
Sirisena N; Human Genetics Unit, Faculty of Medicine, University of Colombo, Colombo, 8, Sri Lanka.
Biswas K; Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Bldg 560, Room 32-33, 1050 Boyles Street, Frederick, MD, 21702, USA.
Sullivan T; Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Bldg 560, Room 32-33, 1050 Boyles Street, Frederick, MD, 21702, USA.
Stauffer S; Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Bldg 560, Room 32-33, 1050 Boyles Street, Frederick, MD, 21702, USA.
Cleveland L; Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Bldg 560, Room 32-33, 1050 Boyles Street, Frederick, MD, 21702, USA.
Southon E; Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Bldg 560, Room 32-33, 1050 Boyles Street, Frederick, MD, 21702, USA.
Dissanayake VHW; Human Genetics Unit, Faculty of Medicine, University of Colombo, Colombo, 8, Sri Lanka.
Sharan SK; Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Bldg 560, Room 32-33, 1050 Boyles Street, Frederick, MD, 21702, USA. .
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Źródło :
Breast cancer research : BCR [Breast Cancer Res] 2020 May 11; Vol. 22 (1), pp. 43. Date of Electronic Publication: 2020 May 11.
Typ publikacji :
Evaluation Study; Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Mutation*
BRCA2 Protein/*genetics
Breast Neoplasms/*genetics
Breast Neoplasms/*pathology
Mouse Embryonic Stem Cells/*metabolism
Neoplastic Syndromes, Hereditary/*genetics
Neoplastic Syndromes, Hereditary/*pathology
Animals ; BRCA2 Protein/metabolism ; Biological Assay/methods ; Breast Neoplasms/epidemiology ; Breast Neoplasms/metabolism ; Cell Survival ; Cohort Studies ; Female ; Homologous Recombination ; Humans ; Mice ; Neoplastic Syndromes, Hereditary/epidemiology ; Neoplastic Syndromes, Hereditary/metabolism ; Sri Lanka/epidemiology ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Systematic review of acceptability, cardiovascular, neurological, bone health and HRT outcomes following risk reducing surgery in BRCA carriers.
Autorzy :
Gaba F; Wolfson Institute of Preventive Medicine, Barts CRUK Cancer Centre, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK; Department of Gynaecological Oncology, St Bartholomew's Hospital, London, EC1A 7BE, UK.
Manchanda R; Wolfson Institute of Preventive Medicine, Barts CRUK Cancer Centre, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK; Department of Gynaecological Oncology, St Bartholomew's Hospital, London, EC1A 7BE, UK; MRC Clinical Trials Unit, University College London, 90 High Holborn, London, WC1V 6LJ, UK. Electronic address: .
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Źródło :
Best practice & research. Clinical obstetrics & gynaecology [Best Pract Res Clin Obstet Gynaecol] 2020 May; Vol. 65, pp. 46-65. Date of Electronic Publication: 2020 Feb 04.
Typ publikacji :
Journal Article; Systematic Review
MeSH Terms :
BRCA1 Protein/*genetics
BRCA2 Protein/*genetics
Bone Density/*physiology
Ovarian Neoplasms/*prevention & control
Ovarian Neoplasms/*surgery
Ovariectomy/*methods
Salpingectomy/*methods
Salpingo-oophorectomy/*methods
BRCA1 Protein/metabolism ; BRCA2 Protein/metabolism ; Female ; Genetic Predisposition to Disease ; Heterozygote ; Hormone Replacement Therapy ; Humans ; Mutation ; Ovarian Neoplasms/genetics ; Ovariectomy/adverse effects ; Salpingectomy/adverse effects ; Salpingo-oophorectomy/adverse effects
Czasopismo naukowe
Tytuł :
Design of BRC analogous peptides based on the complex BRC8-RAD51 and the preliminary study on the peptide structures.
Autorzy :
Zhao D; School of Chemistry and Chemical Engineering, Henan University of Technology, Zhengzhou, 450001, China. .
Lu K; School of Chemistry and Chemical Engineering, Henan University of Technology, Zhengzhou, 450001, China. .; School of Chemical Engineering and Food Science, Zhengzhou Institute of Technology, Zhengzhou, 450044, China. .
Liu G; School of Chemistry and Chemical Engineering, Henan University of Technology, Zhengzhou, 450001, China.; College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, 450007, China.
Zhu H; Chemical Industry Research Institute Co. Ltd. of Henan Province, Zhengzhou, 450052, China.
Ma L; School of Chemistry and Chemical Engineering, Henan University of Technology, Zhengzhou, 450001, China.
Qi J; Shananxi Key Laboratory of Natural Product & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, 712100, China.; Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Educationand School of Pharmaceutical Science, Wuhan University, Wuhan, 430072, China.
Yuan L; School of Chemistry and Chemical Engineering, Henan University of Technology, Zhengzhou, 450001, China.
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Źródło :
Amino acids [Amino Acids] 2020 May; Vol. 52 (5), pp. 831-839. Date of Electronic Publication: 2020 May 16.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Design*
BRCA2 Protein/*chemistry
Peptide Fragments/*chemistry
Rad51 Recombinase/*chemistry
BRCA2 Protein/metabolism ; Humans ; Protein Conformation ; Rad51 Recombinase/metabolism
Czasopismo naukowe
Tytuł :
BRCA1 and BRCA2 Gene Mutations and Lung Cancer Sisk: A Meta-Analysis.
Autorzy :
Lee YC; Department of Oncology, Tainan Hospital, Ministry of Health and Welfare, Tainan 700, Taiwan.; Department of Internal Medicine, National Cheng Kung University Hospital, College, Tainan 700, Taiwan.
Lee YC; Tainan Municipal Hospital, Tainan, Taiwan.
Li CY; Department of Public Health, College of Medicine, National Cheng Kung University, Tainan 700, Taiwan.; Department of Public Health, College of Public Health, China Medical University, Taichung 404, Taiwan.; Department of Healthcare Administration, College of Medical and Health Science, Asia University, Taichung 413, Taiwan.
Lee YL; Department of Oncology, Tainan Hospital, Ministry of Health and Welfare, Tainan 700, Taiwan.
Chen BL; College of Intelligence, National Taichung University of Science and Technology, Taichung 404, Taiwan.
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Źródło :
Medicina (Kaunas, Lithuania) [Medicina (Kaunas)] 2020 Apr 27; Vol. 56 (5). Date of Electronic Publication: 2020 Apr 27.
Typ publikacji :
Journal Article; Meta-Analysis; Systematic Review
MeSH Terms :
BRCA1 Protein/*analysis
BRCA2 Protein/*analysis
Lung Neoplasms/*blood
Adult ; Aged ; BRCA1 Protein/blood ; BRCA2 Protein/blood ; Female ; Genetic Predisposition to Disease ; Humans ; Incidence ; Mass Screening/methods ; Middle Aged ; Odds Ratio ; Retrospective Studies
Czasopismo naukowe
Tytuł :
Immunohistochemistry for the detection of BRCA1 and BRCA2 proteins in patients with ovarian cancer: a systematic review.
Autorzy :
Teixeira LA; Postgraduate Program in Gynecology and Obstetrics, Department of Gynecology and Obstetrics, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil.
Candido Dos Reis FJ; Postgraduate Program in Gynecology and Obstetrics, Department of Gynecology and Obstetrics, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil .
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Źródło :
Journal of clinical pathology [J Clin Pathol] 2020 Apr; Vol. 73 (4), pp. 191-196. Date of Electronic Publication: 2019 Nov 12.
Typ publikacji :
Journal Article; Systematic Review
MeSH Terms :
BRCA1 Protein/*metabolism
BRCA2 Protein/*metabolism
Ovarian Neoplasms/*mortality
Antibodies/metabolism ; BRCA1 Protein/immunology ; BRCA2 Protein/immunology ; Female ; Humans ; Immunohistochemistry ; Risk Factors
Czasopismo naukowe
Tytuł :
Synthetic Lethality in Pancreatic Cancer: Discovery of a New RAD51-BRCA2 Small Molecule Disruptor That Inhibits Homologous Recombination and Synergizes with Olaparib.
Autorzy :
Bagnolini G; Computational and Chemical Biology, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genoa, Italy.; Department of Pharmacy and Biotechnology, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy.
Milano D; Computational and Chemical Biology, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genoa, Italy.
Manerba M; Computational and Chemical Biology, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genoa, Italy.
Schipani F; Computational and Chemical Biology, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genoa, Italy.
Ortega JA; Computational and Chemical Biology, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genoa, Italy.
Gioia D; Computational and Chemical Biology, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genoa, Italy.
Falchi F; Computational and Chemical Biology, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genoa, Italy.
Balboni A; Computational and Chemical Biology, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genoa, Italy.; Department of Pharmacy and Biotechnology, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy.
Farabegoli F; Department of Pharmacy and Biotechnology, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy.
De Franco F; TES Pharma S.r.l., Via Palmiro Togliatti 22bis, I-06073 Corciano, Perugia, Italy.
Robertson J; TES Pharma S.r.l., Via Palmiro Togliatti 22bis, I-06073 Corciano, Perugia, Italy.
Pellicciari R; TES Pharma S.r.l., Via Palmiro Togliatti 22bis, I-06073 Corciano, Perugia, Italy.
Pallavicini I; Department of Experimental Oncology at the IEO, European Institute of Oncology IRCCS, IFOM-IEO Campus, Via Adamello 16, 20100 Milan, Italy.
Peri S; Department of Experimental Oncology at the IEO, European Institute of Oncology IRCCS, IFOM-IEO Campus, Via Adamello 16, 20100 Milan, Italy.
Minucci S; Department of Biosciences, University of Milan, Via Celoria 26, 20100 Milan, Italy.; Department of Experimental Oncology at the IEO, European Institute of Oncology IRCCS, IFOM-IEO Campus, Via Adamello 16, 20100 Milan, Italy.
Girotto S; Computational and Chemical Biology, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genoa, Italy.
Di Stefano G; Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Via S. Giacomo 14, 40126 Bologna, Italy.
Roberti M; Department of Pharmacy and Biotechnology, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy.
Cavalli A; Computational and Chemical Biology, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genoa, Italy.; Department of Pharmacy and Biotechnology, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2020 Mar 12; Vol. 63 (5), pp. 2588-2619. Date of Electronic Publication: 2020 Feb 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adenocarcinoma/*drug therapy
Antineoplastic Agents/*pharmacology
BRCA2 Protein/*metabolism
Pancreatic Neoplasms/*drug therapy
Phthalazines/*pharmacology
Piperazines/*pharmacology
Rad51 Recombinase/*metabolism
Adenocarcinoma/genetics ; Adenocarcinoma/metabolism ; Antineoplastic Agents/chemistry ; BRCA2 Protein/genetics ; Cell Line, Tumor ; DNA Damage/drug effects ; Drug Discovery ; Drug Synergism ; Homologous Recombination/drug effects ; Humans ; Models, Molecular ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/metabolism ; Phthalazines/chemistry ; Piperazines/chemistry ; Poly(ADP-ribose) Polymerase Inhibitors/chemistry ; Poly(ADP-ribose) Polymerase Inhibitors/pharmacology ; Protein Interaction Maps/drug effects ; Small Molecule Libraries/chemistry ; Small Molecule Libraries/pharmacology ; Synthetic Lethal Mutations/drug effects
Czasopismo naukowe
Tytuł :
The association between the methylation frequency of BRCA1/2 gene promoter and occurrence and prognosis of breast carcinoma: A meta-analysis.
Autorzy :
Li S; Clinical Laboratory, Chongqing Health Center for Women and Children.
He Y; Clinical Laboratory, Yongchuan Hospital of Chongqing Medical University, Chongqing.
Li C; Clinical Laboratory, Chongqing Health Center for Women and Children.
Liu X; Clinical Laboratory, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China.
Shen Y; Clinical Laboratory, Chongqing Health Center for Women and Children.
Wu Y; Clinical Laboratory, Yongchuan Hospital of Chongqing Medical University, Chongqing.
Bai N; Clinical Laboratory, Yongchuan Hospital of Chongqing Medical University, Chongqing.
Li Q; Clinical Laboratory, Chongqing Health Center for Women and Children.
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Źródło :
Medicine [Medicine (Baltimore)] 2020 Mar; Vol. 99 (10), pp. e19345.
Typ publikacji :
Journal Article; Meta-Analysis
MeSH Terms :
Prognosis*
BRCA1 Protein/*analysis
BRCA2 Protein/*analysis
Breast Neoplasms/*genetics
DNA Methylation/*genetics
BRCA1 Protein/blood ; BRCA2 Protein/blood ; Biomarkers, Tumor/analysis ; Biomarkers, Tumor/blood ; Breast Neoplasms/physiopathology ; Female ; Humans ; Middle Aged ; Proportional Hazards Models
Czasopismo naukowe
Tytuł :
Deep exploration of PARP inhibitors in breast cancer: monotherapy and combination therapy.
Autorzy :
Chen Z; Department of Medical Oncology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, People's Republic of China.
Wang X; Department of Medical Oncology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, People's Republic of China.
Li X; Department of Gastrointestinal and Pancreatic Surgery, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, People's Republic of China.
Zhou Y; Department of Gastrointestinal and Pancreatic Surgery, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, People's Republic of China.
Chen K; Department of Gastrointestinal and Pancreatic Surgery, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, People's Republic of China.
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Źródło :
The Journal of international medical research [J Int Med Res] 2021 Feb; Vol. 49 (2), pp. 300060521991019.
Typ publikacji :
Journal Article; Meta-Analysis; Systematic Review
MeSH Terms :
Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
Poly(ADP-ribose) Polymerase Inhibitors/*therapeutic use
Triple Negative Breast Neoplasms/*drug therapy
BRCA1 Protein/genetics ; BRCA2 Protein/genetics ; Female ; Humans ; Mutation ; Neoplasm Staging ; Progression-Free Survival ; Randomized Controlled Trials as Topic ; Triple Negative Breast Neoplasms/genetics ; Triple Negative Breast Neoplasms/mortality ; Triple Negative Breast Neoplasms/pathology
Czasopismo naukowe

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