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Tytuł:
TET Enzymes and 5hmC Levels in Carcinogenesis and Progression of Breast Cancer: Potential Therapeutic Targets.
Autorzy:
Salmerón-Bárcenas EG; Departamento de Biomedicina Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Ciudad de México C.P. 07360, Mexico.
Zacapala-Gómez AE; Laboratorio de Biomedicina Molecular, Facultad de Ciencias Químico-Biológicas, Universidad Autónoma de Guerrero, Chilpancingo C. P. 39090, Guerrero, Mexico.
Torres-Rojas FI; Laboratorio de Biomedicina Molecular, Facultad de Ciencias Químico-Biológicas, Universidad Autónoma de Guerrero, Chilpancingo C. P. 39090, Guerrero, Mexico.
Antonio-Véjar V; Laboratorio de Biomedicina Molecular, Facultad de Ciencias Químico-Biológicas, Universidad Autónoma de Guerrero, Chilpancingo C. P. 39090, Guerrero, Mexico.
Ávila-López PA; Departamento de Biomedicina Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Ciudad de México C.P. 07360, Mexico.
Baños-Hernández CJ; Instituto de Investigación en Ciencias Biomédicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara C. P. 44340, Jalisco, Mexico.
Núñez-Martínez HN; Departamento de Genética Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad de México C. P. 04510, Mexico.
Dircio-Maldonado R; Laboratorio de Investigación Clínica, Facultad de Ciencias Químico-Biológicas, Universidad Autónoma de Guerrero, Chilpancingo C. P. 39090, Guerrero, Mexico.
Martínez-Carrillo DN; Laboratorio de Investigación Clínica, Facultad de Ciencias Químico-Biológicas, Universidad Autónoma de Guerrero, Chilpancingo C. P. 39090, Guerrero, Mexico.; Laboratorio de Investigación en Biomoléculas, Facultad de Ciencias Químico-Biológicas, Universidad Autónoma de Guerrero, Chilpancingo C. P. 39090, Guerrero, Mexico.
Ortiz-Ortiz J; Laboratorio de Biomedicina Molecular, Facultad de Ciencias Químico-Biológicas, Universidad Autónoma de Guerrero, Chilpancingo C. P. 39090, Guerrero, Mexico.
Jiménez-Wences H; Laboratorio de Investigación Clínica, Facultad de Ciencias Químico-Biológicas, Universidad Autónoma de Guerrero, Chilpancingo C. P. 39090, Guerrero, Mexico.; Laboratorio de Investigación en Biomoléculas, Facultad de Ciencias Químico-Biológicas, Universidad Autónoma de Guerrero, Chilpancingo C. P. 39090, Guerrero, Mexico.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Dec 24; Vol. 25 (1). Date of Electronic Publication: 2023 Dec 24.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Breast Neoplasms*/drug therapy
Breast Neoplasms*/genetics
Humans ; Female ; BRCA1 Protein ; BRCA2 Protein ; Carcinogenesis/genetics ; DNA
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
BRCA Mutations and Fertility Preservation.
Autorzy:
Dias Nunes J; Research Laboratory on Human Reproduction, Université Libre de Bruxelles (ULB), 1070 Brussels, Belgium.
Demeestere I; Research Laboratory on Human Reproduction, Université Libre de Bruxelles (ULB), 1070 Brussels, Belgium.; Fertility Clinic, HUB-Erasme Hospital, Université Libre de Bruxelles (ULB), 1070 Brussels, Belgium.
Devos M; Research Laboratory on Human Reproduction, Université Libre de Bruxelles (ULB), 1070 Brussels, Belgium.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Dec 22; Vol. 25 (1). Date of Electronic Publication: 2023 Dec 22.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Fertility Preservation*
Breast Neoplasms*/drug therapy
Breast Neoplasms*/genetics
Infertility, Male*
Adolescent ; Young Adult ; Humans ; Female ; Male ; BRCA1 Protein/genetics ; BRCA2 Protein/genetics ; Mutation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Small-scale mutations are infrequent as mechanisms of resistance in post-PARP inhibitor tumour samples in high grade serous ovarian cancer.
Autorzy:
Burdett NL; Peter MacCallum Cancer Centre, Melbourne, VIC, 3000, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Victoria, 3010, Australia.; Box Hill Hospital, Eastern Health, Box Hill, Victoria, 3128, Australia.
Willis MO; Peter MacCallum Cancer Centre, Melbourne, VIC, 3000, Australia.
Pandey A; Peter MacCallum Cancer Centre, Melbourne, VIC, 3000, Australia.
Fereday S; Peter MacCallum Cancer Centre, Melbourne, VIC, 3000, Australia.
DeFazio A; Centre for Cancer Research, The Westmead Institute for Medical Research, Sydney, NSW, 2145, Australia.; The Daffodil Centre, The University of Sydney, a joint venture with Cancer Council NSW, Sydney, NSW, 2006, Australia.; Department of Gynaecological Oncology, Westmead Hospital, Sydney, NSW, 2145, Australia.
Bowtell DDL; Peter MacCallum Cancer Centre, Melbourne, VIC, 3000, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Victoria, 3010, Australia.
Christie EL; Peter MacCallum Cancer Centre, Melbourne, VIC, 3000, Australia. .; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Victoria, 3010, Australia. .
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Corporate Authors:
AOCS Study Group
Źródło:
Scientific reports [Sci Rep] 2023 Dec 11; Vol. 13 (1), pp. 21884. Date of Electronic Publication: 2023 Dec 11.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents*/therapeutic use
Ovarian Neoplasms*/drug therapy
Ovarian Neoplasms*/genetics
Ovarian Neoplasms*/pathology
Humans ; Female ; Poly(ADP-ribose) Polymerase Inhibitors/pharmacology ; Poly(ADP-ribose) Polymerase Inhibitors/therapeutic use ; BRCA1 Protein/genetics ; BRCA2 Protein/genetics ; Mutation ; Tumor Microenvironment
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Combining Novel Hormonal Therapies with a Poly (ADP-Ribose) Polymerase Inhibitor for Metastatic Castration-Resistant Prostate Cancer: Emerging Evidence.
Autorzy:
Yang J; Department of Urology, Institute of Urology, Center of Biomedical Big Data and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu 610041, China.
Xiong X; Department of Urology, Institute of Urology, Center of Biomedical Big Data and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu 610041, China.
Zheng W; Department of Urology, Institute of Urology, Center of Biomedical Big Data and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu 610041, China.
Liao X; Department of Urology, Institute of Urology, Center of Biomedical Big Data and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu 610041, China.
Xu H; Department of Urology, Institute of Urology, Center of Biomedical Big Data and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu 610041, China.
Yang L; Department of Urology, Institute of Urology, Center of Biomedical Big Data and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu 610041, China.
Wei Q; Department of Urology, Institute of Urology, Center of Biomedical Big Data and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu 610041, China.
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Źródło:
Current oncology (Toronto, Ont.) [Curr Oncol] 2023 Dec 04; Vol. 30 (12), pp. 10311-10324. Date of Electronic Publication: 2023 Dec 04.
Typ publikacji:
Systematic Review; Journal Article; Review
MeSH Terms:
Prostatic Neoplasms, Castration-Resistant*/drug therapy
Antineoplastic Agents*/therapeutic use
Male ; Humans ; Poly(ADP-ribose) Polymerase Inhibitors/adverse effects ; BRCA1 Protein ; Ribose/therapeutic use ; BRCA2 Protein/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Homologous Recombination Deficiency (HRD) Scoring, by Means of Two Different Shallow Whole-Genome Sequencing Pipelines (sWGS), in Ovarian Cancer Patients: A Comparison with Myriad MyChoice Assay.
Autorzy:
Scaglione GL; Laboratory of Molecular Oncology, IDI-IRCCS, Via dei Monti di Creta, 104, 00167 Rome, Italy.
Pignata S; Department of Urology and Gynecology, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale, Via Mariano Semmola, 53, 80131 Naples, Italy.
Pettinato A; Department of Pathological Anatomy, A.O.E. Cannizzaro, Via Messina, 829, 95126 Catania, Italy.
Paolillo C; Department of Clinical and Experimental Medicine, University of Foggia, Viale Luigi Pinto, 71122 Foggia, Italy.
Califano D; Functional Genomic Unit, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale, Via Mariano Semmola, 53, 80131 Naples, Italy.
Scandurra G; Department of Medical Oncology, A.O.E. Cannizzaro, Via Messina, 829, 95126 Catania, Italy.
Lombardo V; Department of Medical Oncology, A.O.E. Cannizzaro, Via Messina, 829, 95126 Catania, Italy.
Di Gaudio F; A.O.U.P. Paolo Giaccone, Via del Vespro, 129, 90127 Palermo, Italy.
Pecorino B; Department of Obstetrics and Gynecology, A.O.E. Cannizzaro, Via Messina, 829, 95126 Catania, Italy.
Mereu L; Division of Obstetrics and Gynecology, Department of General Surgery and Medical-Surgical Specialism, University of Catania, P.O. 'G Rodolico', Via Santa Sofia, 78, 95123 Catania, Italy.
Scollo P; Department of Obstetrics and Gynecology, A.O.E. Cannizzaro, Via Messina, 829, 95126 Catania, Italy.; Faculty of Medicine, 'Kore' University, Cittadella Universitaria, 94100 Enna, Italy.
Capoluongo ED; Department of Clinical Pathology and Genomics, A.O.E. Cannizzaro, Via Messina 829, 95126 Catania, Italy.; Department of Molecular Medicine and Medical Biotechnology, Federico II University, Via Pansini, 5, 80131 Naples, Italy.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Dec 04; Vol. 24 (23). Date of Electronic Publication: 2023 Dec 04.
Typ publikacji:
Journal Article
MeSH Terms:
BRCA1 Protein*/genetics
Ovarian Neoplasms*/drug therapy
Ovarian Neoplasms*/genetics
Humans ; Female ; Mutation ; BRCA2 Protein/genetics ; Retrospective Studies ; Homologous Recombination
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
PSPC1 Inhibition Synergizes with Poly(ADP-ribose) Polymerase Inhibitors in a Preclinical Model of BRCA-Mutated Breast/Ovarian Cancer.
Autorzy:
Ghosh M; Department of Biomedical Science, The Graduate School, CHA University, Seongnam-si 13488, Republic of Korea.
Kang MS; Department of Biomedical Science, The Graduate School, CHA University, Seongnam-si 13488, Republic of Korea.
Katuwal NB; Department of Biomedical Science, The Graduate School, CHA University, Seongnam-si 13488, Republic of Korea.
Hong SD; Department of Biomedical Science, The Graduate School, CHA University, Seongnam-si 13488, Republic of Korea.
Jeong YG; Department of Biomedical Science, The Graduate School, CHA University, Seongnam-si 13488, Republic of Korea.
Park SM; Department of Biomedical Science, The Graduate School, CHA University, Seongnam-si 13488, Republic of Korea.
Kim SG; Hematology and Oncology, Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam-si 13496, Republic of Korea.
Moon YW; Hematology and Oncology, Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam-si 13496, Republic of Korea.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Dec 03; Vol. 24 (23). Date of Electronic Publication: 2023 Dec 03.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents*/therapeutic use
Poly(ADP-ribose) Polymerase Inhibitors*/therapeutic use
Ovarian Neoplasms*/drug therapy
Breast Neoplasms*/drug therapy
Animals ; Humans ; Female ; Mice ; Cell Line, Tumor ; RNA-Binding Proteins/antagonists & inhibitors ; BRCA1 Protein/genetics ; BRCA2 Protein/genetics ; RNA, Small Interfering/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Pathogenic germline variants in BRCA1 and TP53 increase lung cancer risk in Chinese.
Autorzy:
Wei B; Department of Molecular Pathology, Henan Key Laboratory of Molecular Pathology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, Henan, China.
Zhao J; Nanjing Shenyou Institute of Genome Research, Nanjing, Jiangsu, China.
Li J; Department of Molecular Pathology, Henan Key Laboratory of Molecular Pathology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, Henan, China.
Feng J; Department of Molecular Pathology, Henan Key Laboratory of Molecular Pathology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, Henan, China.
Sun M; Nanjing Shenyou Institute of Genome Research, Nanjing, Jiangsu, China.
Wang Z; Department of Molecular Pathology, Henan Key Laboratory of Molecular Pathology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, Henan, China.
Shi C; Department of Molecular Pathology, Henan Key Laboratory of Molecular Pathology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, Henan, China.
Yang K; Department of Molecular Pathology, Henan Key Laboratory of Molecular Pathology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, Henan, China.
Qin Y; Nanjing Shenyou Institute of Genome Research, Nanjing, Jiangsu, China.
Zhang J; Nanjing Shenyou Institute of Genome Research, Nanjing, Jiangsu, China.
Ma J; Department of Molecular Pathology, Henan Key Laboratory of Molecular Pathology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, Henan, China.
Dong H; Department of Gastroenterology, Shanghai Key Laboratory of Pancreatic Diseases, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
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Źródło:
Cancer medicine [Cancer Med] 2023 Dec; Vol. 12 (23), pp. 21219-21228. Date of Electronic Publication: 2023 Nov 06.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Genetic Predisposition to Disease*
Lung Neoplasms*/epidemiology
Lung Neoplasms*/genetics
Humans ; Case-Control Studies ; BRCA2 Protein/genetics ; BRCA1 Protein/genetics ; Germ-Line Mutation ; China/epidemiology ; Germ Cells ; Tumor Suppressor Protein p53/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Early-Onset Ovarian Cancer <30 Years: What Do We Know about Its Genetic Predisposition?
Autorzy:
Horackova K; Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University and General University Hospital in Prague, 128 00 Prague, Czech Republic.
Janatova M; Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University and General University Hospital in Prague, 128 00 Prague, Czech Republic.
Kleiblova P; Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University and General University Hospital in Prague, 128 00 Prague, Czech Republic.; Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University and General University Hospital in Prague, 128 00 Prague, Czech Republic.
Kleibl Z; Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University and General University Hospital in Prague, 128 00 Prague, Czech Republic.; Institute of Pathological Physiology, First Faculty of Medicine, Charles University, 128 00 Prague, Czech Republic.
Soukupova J; Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University and General University Hospital in Prague, 128 00 Prague, Czech Republic.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Nov 30; Vol. 24 (23). Date of Electronic Publication: 2023 Nov 30.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Genetic Predisposition to Disease*
Ovarian Neoplasms*/pathology
Adult ; Humans ; Female ; BRCA2 Protein/genetics ; BRCA1 Protein/genetics ; Genes, BRCA2 ; Carcinoma, Ovarian Epithelial/genetics ; Risk Factors ; Germ-Line Mutation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Breast cancer surveillance in BRCA positive Sri Lankan women: health equity for a high-risk group at a limited resource setting.
Autorzy:
Liyanage UA; Department of Anatomy, Genetics and Biomedical Informatics, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka. .
Sirisena ND; Department of Anatomy, Genetics and Biomedical Informatics, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.
Deshapriya PC; Department of Anatomy, Genetics and Biomedical Informatics, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.
Dissanayake VHW; Department of Anatomy, Genetics and Biomedical Informatics, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.
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Źródło:
BMC women's health [BMC Womens Health] 2023 Nov 28; Vol. 23 (1), pp. 636. Date of Electronic Publication: 2023 Nov 28.
Typ publikacji:
Journal Article
MeSH Terms:
Breast Neoplasms*/diagnosis
Breast Neoplasms*/genetics
Breast Neoplasms*/surgery
Health Equity*
Male ; Humans ; Female ; BRCA1 Protein/genetics ; Mastectomy ; Retrospective Studies ; Sri Lanka/epidemiology ; BRCA2 Protein/genetics ; Mutation ; Genes, BRCA1 ; Mammography ; Magnetic Resonance Imaging ; Genetic Predisposition to Disease
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
BRCA1 and BRCA2 deficient tumour models generate distinct ovarian tumour microenvironments and differential responses to therapy.
Autorzy:
Farokhi Boroujeni S; Cancer Therapeutics Program, Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, ON, K1H 8L6, Canada.; Department of Cellular and Molecular Medicine, University of Ottawa, 451 Smyth Road, Ottawa, ON, K1H 8M5, Canada.
Rodriguez G; Cancer Therapeutics Program, Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, ON, K1H 8L6, Canada.; Department of Cellular and Molecular Medicine, University of Ottawa, 451 Smyth Road, Ottawa, ON, K1H 8M5, Canada.
Galpin K; Cancer Therapeutics Program, Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, ON, K1H 8L6, Canada.; Department of Cellular and Molecular Medicine, University of Ottawa, 451 Smyth Road, Ottawa, ON, K1H 8M5, Canada.
Yakubovich E; Cancer Therapeutics Program, Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, ON, K1H 8L6, Canada.; Department of Cellular and Molecular Medicine, University of Ottawa, 451 Smyth Road, Ottawa, ON, K1H 8M5, Canada.
Murshed H; Cancer Therapeutics Program, Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, ON, K1H 8L6, Canada.; Department of Cellular and Molecular Medicine, University of Ottawa, 451 Smyth Road, Ottawa, ON, K1H 8M5, Canada.
Ibrahim D; Cancer Therapeutics Program, Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, ON, K1H 8L6, Canada.; Department of Cellular and Molecular Medicine, University of Ottawa, 451 Smyth Road, Ottawa, ON, K1H 8M5, Canada.
Asif S; Cancer Therapeutics Program, Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, ON, K1H 8L6, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, 451 Smyth Road, Ottawa, ON, K1H 8M5, Canada.
Vanderhyden BC; Cancer Therapeutics Program, Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, ON, K1H 8L6, Canada. .; Department of Cellular and Molecular Medicine, University of Ottawa, 451 Smyth Road, Ottawa, ON, K1H 8M5, Canada. .
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Źródło:
Journal of ovarian research [J Ovarian Res] 2023 Nov 28; Vol. 16 (1), pp. 231. Date of Electronic Publication: 2023 Nov 28.
Typ publikacji:
Journal Article
MeSH Terms:
B7-H1 Antigen*/genetics
Ovarian Neoplasms*/drug therapy
Ovarian Neoplasms*/genetics
Ovarian Neoplasms*/metabolism
Female ; Humans ; Animals ; Mice ; Tumor Microenvironment/genetics ; Genes, BRCA2 ; BRCA1 Protein/genetics ; Poly(ADP-ribose) Polymerase Inhibitors/pharmacology ; Poly(ADP-ribose) Polymerase Inhibitors/therapeutic use ; BRCA2 Protein/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Globally shared TCR repertoires within the tumor-infiltrating lymphocytes of patients with metastatic gynecologic cancer.
Autorzy:
Kim T; Department of Chemistry, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Korea.
Lim H; Department of Chemistry, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Korea.
Jun S; Department of Chemistry, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Korea.
Park J; Department of Obstetrics and Gynecology, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Korea.
Lee D; Department of Chemistry, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Korea.
Lee JH; Department of Clinical Pharmacology and Therapeutics, College of Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, Korea.; Department of Biomedical Science and Technology, Kyung Hee Medical Science Research Institute, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, Korea.
Lee JY; Department of Obstetrics and Gynecology, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Korea. .
Bang D; Department of Chemistry, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Korea. .
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Źródło:
Scientific reports [Sci Rep] 2023 Nov 22; Vol. 13 (1), pp. 20485. Date of Electronic Publication: 2023 Nov 22.
Typ publikacji:
Journal Article
MeSH Terms:
Ovarian Neoplasms*/genetics
Endometrial Neoplasms*/genetics
Humans ; Female ; BRCA1 Protein ; Lymphocytes, Tumor-Infiltrating ; BRCA2 Protein ; Receptors, Antigen, T-Cell/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
BRACNAC: A BRCA1 and BRCA2 Copy Number Alteration Caller from Next-Generation Sequencing Data.
Autorzy:
Kechin A; Institute of Chemical Biology and Fundamental Medicine, Novosibirsk 630090, Russia.; Faculty of Natural Sciences, Novosibirsk State University, Novosibirsk 630090, Russia.
Boyarskikh U; Institute of Chemical Biology and Fundamental Medicine, Novosibirsk 630090, Russia.
Borobova V; Institute of Chemical Biology and Fundamental Medicine, Novosibirsk 630090, Russia.; Faculty of Natural Sciences, Novosibirsk State University, Novosibirsk 630090, Russia.
Khrapov E; Institute of Chemical Biology and Fundamental Medicine, Novosibirsk 630090, Russia.
Subbotin S; Institute of Chemical Biology and Fundamental Medicine, Novosibirsk 630090, Russia.
Filipenko M; Institute of Chemical Biology and Fundamental Medicine, Novosibirsk 630090, Russia.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Nov 22; Vol. 24 (23). Date of Electronic Publication: 2023 Nov 22.
Typ publikacji:
Journal Article
MeSH Terms:
DNA Copy Number Variations*
Ovarian Neoplasms*/genetics
Ovarian Neoplasms*/diagnosis
Prostatic Neoplasms*/genetics
Female ; Humans ; Male ; BRCA1 Protein/genetics ; BRCA2 Protein/genetics ; Genes, BRCA2 ; High-Throughput Nucleotide Sequencing/methods
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Impact of PARP inhibitor maintenance therapy in newly diagnosed advanced epithelial ovarian cancer: A meta-analysis.
Autorzy:
Lee B; Department of Obstetrics and Gynecology, Inha University Hospital, Inha University College of Medicine, Incheon, Republic of Korea.
Chang SJ; Department of Obstetrics and Gynecology, Ajou University School of Medicine, Suwon-si, Gyeonggi-do, Republic of Korea.
Kwon BS; Department of Obstetrics and Gynecology, School of Medicine, Kyung Hee University Medical Center, Kyung Hee University, Seoul, Republic of Korea.
Son JH; Department of Obstetrics and Gynecology, Ajou University School of Medicine, Suwon-si, Gyeonggi-do, Republic of Korea.
Lim MC; Center for Gynecologic Cancer, Research Institute and Hospital, National Cancer Center, Goyang-si, Gyeonggi-do, Republic of Korea.
Kim YH; Department of Obstetrics and Gynecology, Ewha Womans University Mokdong Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea.
Lee SW; Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.
Choi CH; Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Eoh KJ; Department of Obstetrics and Gynecology, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin-si, Gyeonggi-do, Republic of Korea.
Lee JY; Department of Obstetrics and Gynecology, Yonsei University College of Medicine, Seoul, Republic of Korea.
Suh DH; Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Republic of Korea.
Kim YB; Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Republic of Korea.
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Źródło:
PloS one [PLoS One] 2023 Nov 17; Vol. 18 (11), pp. e0294647. Date of Electronic Publication: 2023 Nov 17 (Print Publication: 2023).
Typ publikacji:
Meta-Analysis; Journal Article
MeSH Terms:
Ovarian Neoplasms*/genetics
Antineoplastic Agents*/therapeutic use
Humans ; Female ; Carcinoma, Ovarian Epithelial/drug therapy ; Poly(ADP-ribose) Polymerase Inhibitors/adverse effects ; BRCA1 Protein/genetics ; BRCA2 Protein/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A Single nucleotide polymorphism in the ALDH2 gene modifies the risk of esophageal squamous cell carcinoma in BRCA2 p.K3326* carriers.
Autorzy:
Zamani N; Women's College Research Institute, University of Toronto, Toronto, Canada.; Faculty of Medicine, Institite of Medical Science, University of Toronto, Toronto, Canada.
Szymiczek A; Women's College Research Institute, University of Toronto, Toronto, Canada.
Shakeri R; Digestive Disease Research Institute, Tehran University of Medical Science, Tehran, Iran.
Poustchi H; Digestive Disease Research Institute, Tehran University of Medical Science, Tehran, Iran.
Pourshams A; Digestive Disease Research Institute, Tehran University of Medical Science, Tehran, Iran.
Narod S; Women's College Research Institute, University of Toronto, Toronto, Canada.; Faculty of Medicine, Institite of Medical Science, University of Toronto, Toronto, Canada.; Dalla Lana School of Public Health, University of Toronto, Toronto, Canada.
Malekzadeh R; Digestive Disease Research Institute, Tehran University of Medical Science, Tehran, Iran.
Akbari MR; Women's College Research Institute, University of Toronto, Toronto, Canada.; Faculty of Medicine, Institite of Medical Science, University of Toronto, Toronto, Canada.; Dalla Lana School of Public Health, University of Toronto, Toronto, Canada.
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Źródło:
PloS one [PLoS One] 2023 Nov 09; Vol. 18 (11), pp. e0292611. Date of Electronic Publication: 2023 Nov 09 (Print Publication: 2023).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Esophageal Squamous Cell Carcinoma*/genetics
Esophageal Squamous Cell Carcinoma*/complications
Carcinoma, Squamous Cell*/pathology
Esophageal Neoplasms*/pathology
Breast Neoplasms*/complications
Humans ; Female ; Polymorphism, Single Nucleotide ; Case-Control Studies ; Genetic Predisposition to Disease ; Risk Factors ; Aldehyde Dehydrogenase, Mitochondrial/genetics ; Genotype ; BRCA2 Protein/genetics
Czasopismo naukowe
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Tytuł:
Association of Germline Variation in Driver Genes with Breast Cancer Risk in Chilean Population.
Autorzy:
Morales-Pison S; Centro de Oncología de Precisión (COP), Facultad de Medicina y Ciencias de la Salud, Universidad Mayor, Las Condes, Santiago 7560908, Chile.
Tapia JC; Laboratorio de Transformación Celular, Programa de Biología Celular y Molecular, Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Independencia, Santiago 783090, Chile.
Morales-González S; Laboratorio de Genética Humana, Programa de Genética Humana, Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Independencia, Santiago 783090, Chile.
Maldonado E; Programa de Biología Celular y Molecular, Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Independencia, Santiago 783090, Chile.
Acuña M; Laboratorio de Genética Humana, Programa de Genética Humana, Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Independencia, Santiago 783090, Chile.
Calaf GM; Instituto de Alta Investigación, Universidad de Tarapacá, Arica 1010069, Chile.
Jara L; Laboratorio de Genética Humana, Programa de Genética Humana, Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Independencia, Santiago 783090, Chile.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Nov 08; Vol. 24 (22). Date of Electronic Publication: 2023 Nov 08.
Typ publikacji:
Journal Article
MeSH Terms:
Breast Neoplasms*/epidemiology
Breast Neoplasms*/genetics
Humans ; Female ; BRCA1 Protein/genetics ; Chile/epidemiology ; Genetic Predisposition to Disease ; BRCA2 Protein/genetics ; Germ-Line Mutation ; Germ Cells ; Polymorphism, Single Nucleotide
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Homologous recombination deficiency (HRD) testing on cell-free tumor DNA from peritoneal fluid.
Autorzy:
Roussel-Simonin C; Drug Development Department (DITEP), Gustave-Roussy Cancer Campus, Villejuif. Sorbonne Université, Paris, France. .
Blanc-Durand F; Departement of Medecine, Gustave-Roussy Cancer Campus, INSERM U981, Université Paris-Saclay, Villejuif, France.; Université Paris-Saclay, Gustave-Roussy Cancer Campus, Inserm U981, Villejuif, France.
Tang R; Cancer Genetics Laboratory, Medical Biology and Pathology Department, Gustave-Roussy Cancer Campus, Villejuif, France.
Vasseur D; Cancer Genetics Laboratory, Medical Biology and Pathology Department, Gustave-Roussy Cancer Campus, Villejuif, France.
Le Formal A; Université Paris-Saclay, Gustave-Roussy Cancer Campus, Inserm U981, Villejuif, France.
Chardin L; Université Paris-Saclay, Gustave-Roussy Cancer Campus, Inserm U981, Villejuif, France.
Yaniz E; Université Paris-Saclay, Gustave-Roussy Cancer Campus, Inserm U981, Villejuif, France.
Gouy S; Department of Pathology and Medical Biology, Gustave-Roussy Cancer Campus, Villejuif, France.
Maulard A; Department of Pathology and Medical Biology, Gustave-Roussy Cancer Campus, Villejuif, France.
Scherier S; Department of Pathology and Medical Biology, Gustave-Roussy Cancer Campus, Villejuif, France.
Sanson C; Department of Pathology and Medical Biology, Gustave-Roussy Cancer Campus, Villejuif, France.
Lacroix L; Department of Gynecologic Surgery, Gustave-Roussy Cancer Campus, Villejuif, France.
Cotteret S; Cancer Genetics Laboratory, Medical Biology and Pathology Department, Gustave-Roussy Cancer Campus, Villejuif, France.
Mauny L; Department of Pathology and Medical Biology, Gustave-Roussy Cancer Campus, Villejuif, France.
Zaccarini F; Department of Pathology and Medical Biology, Gustave-Roussy Cancer Campus, Villejuif, France.
Rouleau E; Université Paris-Saclay, Gustave-Roussy Cancer Campus, Inserm U981, Villejuif, France.; Cancer Genetics Laboratory, Medical Biology and Pathology Department, Gustave-Roussy Cancer Campus, Villejuif, France.
Leary A; Departement of Medecine, Gustave-Roussy Cancer Campus, INSERM U981, Université Paris-Saclay, Villejuif, France.; Université Paris-Saclay, Gustave-Roussy Cancer Campus, Inserm U981, Villejuif, France.
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Źródło:
Molecular cancer [Mol Cancer] 2023 Nov 06; Vol. 22 (1), pp. 178. Date of Electronic Publication: 2023 Nov 06.
Typ publikacji:
Journal Article
MeSH Terms:
Ovarian Neoplasms*/genetics
Circulating Tumor DNA*
Female ; Humans ; BRCA1 Protein/genetics ; BRCA2 Protein/genetics ; Mutation ; Homologous Recombination ; Ascitic Fluid/pathology ; Ascites ; Prospective Studies ; Retrospective Studies ; Carcinoma, Ovarian Epithelial ; Genomic Instability
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Multi-scale characterisation of homologous recombination deficiency in breast cancer.
Autorzy:
Jacobson DH; UCL Genetics Institute, Department of Genetics, Evolution and Environment, University College London, Gower Street, London, WC1E 6BT, UK.; UCL Cancer Institute, University College London, Paul O'Gorman Building, 72 Huntley Street, London, WC1E 6BT, UK.
Pan S; UCL Genetics Institute, Department of Genetics, Evolution and Environment, University College London, Gower Street, London, WC1E 6BT, UK.
Fisher J; UCL Cancer Institute, University College London, Paul O'Gorman Building, 72 Huntley Street, London, WC1E 6BT, UK.
Secrier M; UCL Genetics Institute, Department of Genetics, Evolution and Environment, University College London, Gower Street, London, WC1E 6BT, UK. .
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Źródło:
Genome medicine [Genome Med] 2023 Nov 02; Vol. 15 (1), pp. 90. Date of Electronic Publication: 2023 Nov 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Breast Neoplasms*/genetics
Breast Neoplasms*/pathology
Antineoplastic Agents*/therapeutic use
Humans ; Female ; BRCA1 Protein/genetics ; Poly(ADP-ribose) Polymerase Inhibitors/therapeutic use ; Likelihood Functions ; BRCA2 Protein/genetics ; Homologous Recombination ; Tumor Microenvironment
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The Mechanistic Understanding of RAD51 Defibrillation: A Critical Step in BRCA2-Mediated DNA Repair by Homologous Recombination.
Autorzy:
Schipani F; Computational and Chemical Biology, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genoa, Italy.
Manerba M; Computational and Chemical Biology, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genoa, Italy.
Marotta R; Electron Microscopy Facility, Istituto Italiano di Tecnologia, Via Morego, 30, 16163 Genoa, Italy.
Poppi L; Department of Pharmacy and Biotechnology, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy.
Gennari A; Laboratory of Polymers and Biomaterials, Istituto Italiano di Tecnologia, Via Morego, 30, 16163 Genoa, Italy.
Rinaldi F; Computational and Chemical Biology, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genoa, Italy.
Armirotti A; Analytical Chemistry Lab, Istituto Italiano di Tecnologia, Via Morego, 30, 16163 Genoa, Italy.
Farabegoli F; Department of Pharmacy and Biotechnology, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy.
Roberti M; Department of Pharmacy and Biotechnology, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy.
Di Stefano G; Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Via S. Giacomo 14, 40126 Bologna, Italy.
Rocchia W; CONCEPT Lab, Istituto Italiano di Tecnologia, Via E. Melen 83, 16152 Genoa, Italy.
Girotto S; Computational and Chemical Biology, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genoa, Italy.
Tirelli N; Laboratory of Polymers and Biomaterials, Istituto Italiano di Tecnologia, Via Morego, 30, 16163 Genoa, Italy.; School of Health Sciences, University of Manchester, Oxford Road, Manchester M13 9PL, UK.
Cavalli A; Computational and Chemical Biology, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genoa, Italy.; Department of Pharmacy and Biotechnology, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Jul 28; Vol. 23 (15). Date of Electronic Publication: 2022 Jul 28.
Typ publikacji:
Journal Article
MeSH Terms:
BRCA2 Protein*/genetics
BRCA2 Protein*/metabolism
Rad51 Recombinase*/genetics
Rad51 Recombinase*/metabolism
DNA Repair ; Homologous Recombination ; Peptides/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Saturation genome editing of 11 codons and exon 13 of BRCA2 coupled with chemotherapeutic drug response accurately determines pathogenicity of variants.
Autorzy:
Sahu S; Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, United States of America.
Sullivan TL; Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, United States of America.
Mitrophanov AY; Statistical Consulting and Scientific Programming, Frederick National Laboratory for Cancer Research, National Institutes of Health, Frederick, Maryland, United States of America.
Galloux M; Independent bioinformatician, Marseille, France.
Nousome D; CCR Bioinformatics Resource, Leidos Biomedical Sciences, Inc. Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America.
Southon E; Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, United States of America.
Caylor D; Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, United States of America.
Mishra AP; Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, United States of America.
Evans CN; Genome Modification Core, Laboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America.
Clapp ME; Genome Modification Core, Laboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America.
Burkett S; Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, United States of America.
Malys T; Statistical Consulting and Scientific Programming, Frederick National Laboratory for Cancer Research, National Institutes of Health, Frederick, Maryland, United States of America.
Chari R; Genome Modification Core, Laboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America.
Biswas K; Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, United States of America.
Sharan SK; Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, United States of America.
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Źródło:
PLoS genetics [PLoS Genet] 2023 Sep 15; Vol. 19 (9), pp. e1010940. Date of Electronic Publication: 2023 Sep 15 (Print Publication: 2023).
Typ publikacji:
Journal Article; Research Support, N.I.H., Intramural; Research Support, N.I.H., Extramural
MeSH Terms:
Gene Editing*
Breast Neoplasms*/genetics
Animals ; Humans ; Mice ; Female ; Virulence ; BRCA2 Protein/genetics ; BRCA2 Protein/metabolism ; Exons/genetics ; Codon ; Nucleotides ; Genetic Predisposition to Disease ; BRCA1 Protein/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Understanding and predicting the functional consequences of missense mutations in BRCA1 and BRCA2.
Autorzy:
Aljarf R; Computational Biology and Clinical Informatics, Baker Heart and Diabetes Institute, Melbourne, VIC, 3004, Australia.; Department of Biochemistry and Pharmacology, University of Melbourne, Melbourne, VIC, 3010, Australia.; Systems and Computational Biology, Bio21 Institute, University of Melbourne, 30 Flemington Rd, Parkville, VIC, 3052, Australia.
Shen M; Computational Biology and Clinical Informatics, Baker Heart and Diabetes Institute, Melbourne, VIC, 3004, Australia.; Department of Biochemistry and Pharmacology, University of Melbourne, Melbourne, VIC, 3010, Australia.; Systems and Computational Biology, Bio21 Institute, University of Melbourne, 30 Flemington Rd, Parkville, VIC, 3052, Australia.; School of Computing and Information Systems, University of Melbourne, Melbourne, VIC, 3053, Australia.
Pires DEV; Computational Biology and Clinical Informatics, Baker Heart and Diabetes Institute, Melbourne, VIC, 3004, Australia. .; Department of Biochemistry and Pharmacology, University of Melbourne, Melbourne, VIC, 3010, Australia. .; Systems and Computational Biology, Bio21 Institute, University of Melbourne, 30 Flemington Rd, Parkville, VIC, 3052, Australia. .; School of Computing and Information Systems, University of Melbourne, Melbourne, VIC, 3053, Australia. .
Ascher DB; Computational Biology and Clinical Informatics, Baker Heart and Diabetes Institute, Melbourne, VIC, 3004, Australia. .; Department of Biochemistry and Pharmacology, University of Melbourne, Melbourne, VIC, 3010, Australia. .; Systems and Computational Biology, Bio21 Institute, University of Melbourne, 30 Flemington Rd, Parkville, VIC, 3052, Australia. .; Department of Biochemistry, University of Cambridge, 80 Tennis Ct Rd, Cambridge, CB2 1GA, UK. .
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Źródło:
Scientific reports [Sci Rep] 2022 Jun 21; Vol. 12 (1), pp. 10458. Date of Electronic Publication: 2022 Jun 21.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
BRCA1 Protein*/genetics
BRCA2 Protein*/genetics
Breast Neoplasms*/genetics
Mutation, Missense*
Ovarian Neoplasms*/genetics
Female ; Genes, BRCA2 ; Genetic Predisposition to Disease ; High-Throughput Nucleotide Sequencing ; Humans
Czasopismo naukowe
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