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Tytuł :
Protective neutralizing antibodies from human survivors of Crimean-Congo hemorrhagic fever.
Autorzy :
Fels JM; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Maurer DP; Adimab, LLC, Lebanon, NH 03766, USA.
Herbert AS; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA; The Geneva Foundation, Tacoma, WA 98402, USA.
Wirchnianski AS; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Deparment of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Vergnolle O; Deparment of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Cross RW; Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77550, USA; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77550, USA.
Abelson DM; Mapp Biopharmaceutical, Inc., San Diego, CA 92121, USA.
Moyer CL; Mapp Biopharmaceutical, Inc., San Diego, CA 92121, USA.
Mishra AK; Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.
Aguilan JT; Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Kuehne AI; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.
Pauli NT; Adimab, LLC, Lebanon, NH 03766, USA.
Bakken RR; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.
Nyakatura EK; Deparment of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Hellert J; Structural Virology Unit, Department of Virology, CNRS UMR 3569, Institut Pasteur, Paris 75724, France.
Quevedo G; Deparment of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Lobel L; Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel.
Balinandi S; Uganda Virus Research Institute, Entebbe, Uganda.
Lutwama JJ; Uganda Virus Research Institute, Entebbe, Uganda.
Zeitlin L; Mapp Biopharmaceutical, Inc., San Diego, CA 92121, USA.
Geisbert TW; Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77550, USA; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77550, USA.
Rey FA; Structural Virology Unit, Department of Virology, CNRS UMR 3569, Institut Pasteur, Paris 75724, France.
Sidoli S; Deparment of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
McLellan JS; Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.
Lai JR; Deparment of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Bornholdt ZA; Mapp Biopharmaceutical, Inc., San Diego, CA 92121, USA. Electronic address: .
Dye JM; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA. Electronic address: .
Walker LM; Adimab, LLC, Lebanon, NH 03766, USA; Adagio Therapeutics, Inc., Waltham, MA 02451, USA. Electronic address: .
Chandran K; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address: .
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Źródło :
Cell [Cell] 2021 May 26. Date of Electronic Publication: 2021 May 26.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
A small molecule inhibitor of MyD88 exhibits broad spectrum antiviral activity by up regulation of type I interferon.
Autorzy :
Saikh KU; Department of Bacterial Immunology, Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Frederick, MD, 21702, USA. Electronic address: .
Morazzani EM; Virology Division, United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Frederick, MD, 21702, USA.
Piper AE; Virology Division, United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Frederick, MD, 21702, USA.
Bakken RR; Virology Division, United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Frederick, MD, 21702, USA.
Glass PJ; Virology Division, United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Frederick, MD, 21702, USA.
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Źródło :
Antiviral research [Antiviral Res] 2020 Sep; Vol. 181, pp. 104854. Date of Electronic Publication: 2020 Jul 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Czasopismo naukowe
Tytuł :
Development of an antibody cocktail for treatment of Sudan virus infection.
Autorzy :
Herbert AS; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702.; The Geneva Foundation, Tacoma, WA 98402.
Froude JW; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702.
Ortiz RA; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702.
Kuehne AI; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702.
Dorosky DE; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702.
Bakken RR; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702.
Zak SE; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702.; The Geneva Foundation, Tacoma, WA 98402.
Josleyn NM; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702.; The Geneva Foundation, Tacoma, WA 98402.
Musiychuk K; Fraunhofer USA Center for Molecular Biotechnology, Newark, DE 19711.
Jones RM; Fraunhofer USA Center for Molecular Biotechnology, Newark, DE 19711.
Green B; Fraunhofer USA Center for Molecular Biotechnology, Newark, DE 19711.
Streatfield SJ; Fraunhofer USA Center for Molecular Biotechnology, Newark, DE 19711.
Wec AZ; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461.
Bohorova N; Mapp Biopharmaceutical, Inc., San Diego, CA 92121.
Bohorov O; Mapp Biopharmaceutical, Inc., San Diego, CA 92121.
Kim DH; Mapp Biopharmaceutical, Inc., San Diego, CA 92121.
Pauly MH; Mapp Biopharmaceutical, Inc., San Diego, CA 92121.
Velasco J; Mapp Biopharmaceutical, Inc., San Diego, CA 92121.
Whaley KJ; Mapp Biopharmaceutical, Inc., San Diego, CA 92121.
Stonier SW; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702.; The Geneva Foundation, Tacoma, WA 98402.
Bornholdt ZA; Mapp Biopharmaceutical, Inc., San Diego, CA 92121.
Chandran K; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461.
Zeitlin L; Mapp Biopharmaceutical, Inc., San Diego, CA 92121.
Sampey D; BioFactura, Inc., Frederick, MD 21701.
Yusibov V; Fraunhofer USA Center for Molecular Biotechnology, Newark, DE 19711.
Dye JM; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Feb 18; Vol. 117 (7), pp. 3768-3778. Date of Electronic Publication: 2020 Feb 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Antibodies, Viral/*administration & dosage
Ebolavirus/*immunology
Hemorrhagic Fever, Ebola/*drug therapy
Animals ; Antibodies, Monoclonal/administration & dosage ; Disease Models, Animal ; Ebolavirus/genetics ; Female ; Glycoproteins/immunology ; Hemorrhagic Fever, Ebola/virology ; Humans ; Immunotherapy ; Macaca mulatta ; Male ; Mice ; Viral Proteins/immunology
Czasopismo naukowe
Tytuł :
Development of a Human Antibody Cocktail that Deploys Multiple Functions to Confer Pan-Ebolavirus Protection.
Autorzy :
Wec AZ; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Bornholdt ZA; Mapp Biopharmaceutical, San Diego, CA 92121, USA.
He S; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada.
Herbert AS; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.
Goodwin E; Adimab, LLC, Lebanon, NH 03766, USA.
Wirchnianski AS; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Gunn BM; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
Zhang Z; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.
Zhu W; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.
Liu G; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.
Abelson DM; Mapp Biopharmaceutical, San Diego, CA 92121, USA.
Moyer CL; Mapp Biopharmaceutical, San Diego, CA 92121, USA.
Jangra RK; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
James RM; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.
Bakken RR; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.
Bohorova N; Mapp Biopharmaceutical, San Diego, CA 92121, USA.
Bohorov O; Mapp Biopharmaceutical, San Diego, CA 92121, USA.
Kim DH; Mapp Biopharmaceutical, San Diego, CA 92121, USA.
Pauly MH; Mapp Biopharmaceutical, San Diego, CA 92121, USA.
Velasco J; Mapp Biopharmaceutical, San Diego, CA 92121, USA.
Bortz RH 3rd; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Whaley KJ; Mapp Biopharmaceutical, San Diego, CA 92121, USA.
Goldstein T; One Health Institute and Karen C. Drayer Wildlife Health Center, School of Veterinary Medicine, University of California, Davis, Davis, CA 95616, USA.
Anthony SJ; Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY 10032, USA.
Alter G; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
Walker LM; Adimab, LLC, Lebanon, NH 03766, USA.
Dye JM; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.
Zeitlin L; Mapp Biopharmaceutical, San Diego, CA 92121, USA. Electronic address: .
Qiu X; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada. Electronic address: .
Chandran K; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address: .
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Źródło :
Cell host & microbe [Cell Host Microbe] 2019 Jan 09; Vol. 25 (1), pp. 39-48.e5.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Antibodies, Monoclonal/*immunology
Antibodies, Viral/*immunology
Ebolavirus/*immunology
Hemorrhagic Fever, Ebola/*immunology
Hemorrhagic Fever, Ebola/*prevention & control
Animal Welfare ; Animals ; Antibodies, Monoclonal/administration & dosage ; Antibodies, Monoclonal/isolation & purification ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Neutralizing/administration & dosage ; Antibodies, Neutralizing/immunology ; Antibodies, Neutralizing/isolation & purification ; Antibodies, Neutralizing/therapeutic use ; Antibodies, Viral/administration & dosage ; Antibodies, Viral/therapeutic use ; Antiviral Agents ; Disease Models, Animal ; Ebolavirus/pathogenicity ; Epitopes/immunology ; Female ; Filoviridae/immunology ; Guinea Pigs ; Hemorrhagic Fever, Ebola/virology ; Humans ; Immunotherapy ; Mice ; Mice, Inbred BALB C ; Mice, Knockout ; Recombinant Proteins/immunology ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Post-Exposure Protection in Mice against Sudan Virus by a Two Antibody Cocktail.
Autorzy :
Froude JW; US Army Medical Research Institute for Infectious Disease (USAMRIID), Fort Detrick, MD 21702, USA. .
Herbert AS; US Army Medical Research Institute for Infectious Disease (USAMRIID), Fort Detrick, MD 21702, USA. .
Pelat T; Unite de Biotechnologie des Anticorps, Institut de Recherche Biomedicale des Armees (IRBA-CRSSA), La Tronche 38516, France. .
Miethe S; Institut für Biochemie, Biotechnologie und Bioinformatik, Technische Universität Braunschweig, Braunschweig 38106, Germany. .
Zak SE; US Army Medical Research Institute for Infectious Disease (USAMRIID), Fort Detrick, MD 21702, USA. .
Brannan JM; US Army Medical Research Institute for Infectious Disease (USAMRIID), Fort Detrick, MD 21702, USA. .
Bakken RR; US Army Medical Research Institute for Infectious Disease (USAMRIID), Fort Detrick, MD 21702, USA. russell.r.bakken..
Steiner AR; Sutro Biopharma Inc., South San Francisco, CA 94080, USA. .
Yin G; Sutro Biopharma Inc., South San Francisco, CA 94080, USA. .
Hallam TJ; Sutro Biopharma Inc., South San Francisco, CA 94080, USA. .
Sato AK; Sutro Biopharma Inc., South San Francisco, CA 94080, USA. .
Hust M; Institut für Biochemie, Biotechnologie und Bioinformatik, Technische Universität Braunschweig, Braunschweig 38106, Germany. .
Thullier P; Unite de Biotechnologie des Anticorps, Institut de Recherche Biomedicale des Armees (IRBA-CRSSA), La Tronche 38516, France. .
Dye JM; US Army Medical Research Institute for Infectious Disease (USAMRIID), Fort Detrick, MD 21702, USA. john.m.dye1..
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Źródło :
Viruses [Viruses] 2018 May 26; Vol. 10 (6). Date of Electronic Publication: 2018 May 26.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Ebolavirus*
Post-Exposure Prophylaxis*
Antibodies, Viral/*pharmacology
Hemorrhagic Fever, Ebola/*therapy
Membrane Glycoproteins/*immunology
Vaccines, Virus-Like Particle/*immunology
Viral Matrix Proteins/*immunology
Animals ; Antibodies, Neutralizing/pharmacology ; Cell Surface Display Techniques ; Cross Reactions ; Female ; Macaca ; Male ; Mice ; Mice, Knockout ; Single-Chain Antibodies/pharmacology ; Vaccination
Czasopismo naukowe
Tytuł :
Recombinant proteins of Zaire ebolavirus induce potent humoral and cellular immune responses and protect against live virus infection in mice.
Autorzy :
Lehrer AT; PanThera Biopharma, LLC, Aiea, HI 96701, United States. Electronic address: .
Wong TS; PanThera Biopharma, LLC, Aiea, HI 96701, United States.
Lieberman MM; Hawaii Biotech, Inc., Aiea, HI 96701, United States.
Humphreys T; Hawaii Biotech, Inc., Aiea, HI 96701, United States.
Clements DE; Hawaii Biotech, Inc., Aiea, HI 96701, United States.
Bakken RR; US Army Medical Research Institute for Infectious Diseases, Fort Detrick, MD 21702, United States.
Hart MK; US Army Medical Research Institute for Infectious Diseases, Fort Detrick, MD 21702, United States.
Pratt WD; US Army Medical Research Institute for Infectious Diseases, Fort Detrick, MD 21702, United States.
Dye JM; US Army Medical Research Institute for Infectious Diseases, Fort Detrick, MD 21702, United States.
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Źródło :
Vaccine [Vaccine] 2018 May 24; Vol. 36 (22), pp. 3090-3100. Date of Electronic Publication: 2017 Feb 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Ebola Vaccines/*immunology
Hemorrhagic Fever, Ebola/*prevention & control
Viral Envelope Proteins/*immunology
Viral Matrix Proteins/*immunology
Viral Proteins/*immunology
Adjuvants, Immunologic/administration & dosage ; Animals ; Antibodies, Neutralizing/blood ; Antibodies, Viral/blood ; Ebolavirus ; Female ; Hemorrhagic Fever, Ebola/immunology ; Immunity, Cellular ; Immunity, Humoral ; Mice ; Mice, Inbred BALB C ; Vaccines, Subunit/immunology ; Vaccines, Synthetic/immunology
Czasopismo naukowe
Tytuł :
Design and evaluation of bi- and trispecific antibodies targeting multiple filovirus glycoproteins.
Autorzy :
Nyakatura EK; From the Departments of Biochemistry, and.
Zak SE; the Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702, and.
Wec AZ; Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461.
Hofmann D; From the Departments of Biochemistry, and.
Shulenin S; Integrated Biotherapeutics Inc., Gaithersburg, Maryland 20878.
Bakken RR; the Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702, and.
Aman MJ; Integrated Biotherapeutics Inc., Gaithersburg, Maryland 20878.
Chandran K; Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461.
Dye JM; the Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702, and.
Lai JR; From the Departments of Biochemistry, and .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2018 Apr 20; Vol. 293 (16), pp. 6201-6211. Date of Electronic Publication: 2018 Mar 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Engineering*
Antibodies, Bispecific/*immunology
Antibodies, Monoclonal/*immunology
Antibodies, Neutralizing/*immunology
Antibodies, Viral/*immunology
Ebolavirus/*immunology
Glycoproteins/*immunology
Marburgvirus/*immunology
Viral Proteins/*immunology
Animals ; Antibodies, Bispecific/genetics ; Antibodies, Monoclonal/genetics ; Antibodies, Monoclonal/isolation & purification ; Antibodies, Neutralizing/genetics ; Epitopes/immunology ; Female ; Hemorrhagic Fever, Ebola/immunology ; Humans ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Receptor, Interferon alpha-beta/genetics
Czasopismo naukowe
Tytuł :
Mechanistic and Fc requirements for inhibition of Sudan virus entry and in vivo protection by a synthetic antibody.
Autorzy :
Hofmann D; Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA.
Zak SE; Virology Division, United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702, USA.
Nyakatura EK; Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA.
Mittler E; Department of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA.
Bakken RR; Virology Division, United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702, USA.
Chandran K; Department of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA.
Dye JM; Virology Division, United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702, USA.
Lai JR; Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA. Electronic address: .
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Źródło :
Immunology letters [Immunol Lett] 2017 Oct; Vol. 190, pp. 289-295. Date of Electronic Publication: 2017 Sep 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, Non-U.S. Gov't
MeSH Terms :
Ebolavirus/*immunology
Hemorrhagic Fever, Ebola/*immunology
Immunoglobulin Fc Fragments/*genetics
Animals ; Antibodies, Neutralizing/metabolism ; Antibodies, Viral/metabolism ; HEK293 Cells ; Humans ; Membrane Fusion ; Mice ; Mice, Knockout ; Mutation/genetics ; Viral Envelope Proteins/immunology ; Virus Internalization
Czasopismo naukowe
Tytuł :
Antibodies from a Human Survivor Define Sites of Vulnerability for Broad Protection against Ebolaviruses.
Autorzy :
Wec AZ; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Herbert AS; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.
Murin CD; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Nyakatura EK; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Abelson DM; Mapp Biopharmaceutical, San Diego, CA 92121, USA.
Fels JM; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
He S; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.
James RM; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.
de La Vega MA; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.
Zhu W; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.
Bakken RR; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.
Goodwin E; Adimab, LLC, Lebanon, NH 03766, USA.
Turner HL; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Jangra RK; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Zeitlin L; Mapp Biopharmaceutical, San Diego, CA 92121, USA.
Qiu X; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.
Lai JR; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Walker LM; Adimab, LLC, Lebanon, NH 03766, USA.
Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Dye JM; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA. Electronic address: .
Chandran K; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address: .
Bornholdt ZA; Mapp Biopharmaceutical, San Diego, CA 92121, USA. Electronic address: .
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Źródło :
Cell [Cell] 2017 May 18; Vol. 169 (5), pp. 878-890.e15.
Typ publikacji :
Journal Article
MeSH Terms :
Survivors*
Antibodies, Neutralizing/*isolation & purification
Antibodies, Viral/*isolation & purification
Ebola Vaccines/*immunology
Hemorrhagic Fever, Ebola/*immunology
Amino Acid Sequence ; Animals ; Antibodies, Monoclonal/chemistry ; Antibodies, Monoclonal/immunology ; Antibodies, Neutralizing/chemistry ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/chemistry ; Antibodies, Viral/immunology ; Chlorocebus aethiops ; Cross Reactions ; Ebolavirus/classification ; Ebolavirus/immunology ; Female ; Ferrets ; Hemorrhagic Fever, Ebola/virology ; Humans ; Kinetics ; Mice ; Mice, Inbred BALB C ; Models, Molecular ; Sequence Alignment ; Vero Cells
Czasopismo naukowe
Tytuł :
Generation and characterization of protective antibodies to Marburg virus.
Autorzy :
Froude JW; a US Army Medical Research Institute for Infectious Disease (USAMRIID) , Fort Detrick , MD , USA.
Pelat T; b Unite de Biotechnologie des Anticorps, Institut de Recherche Biomedicale des Armees [IRBA-CRSSA] , La Tronche , France.; c BIOTEM, Apprieu , France.
Miethe S; d Technische Universität Braunschweig, Institut für Biochemie, Biotechnologie und Bioinformatik Braunschweig , Germany.; e YUMAB GmbH, Rebenring , Braunschweig , Germany.
Zak SE; a US Army Medical Research Institute for Infectious Disease (USAMRIID) , Fort Detrick , MD , USA.
Wec AZ; f Department of Microbiology and Immunology , Albert Einstein College of Medicine , Bronx , NY , USA.
Chandran K; f Department of Microbiology and Immunology , Albert Einstein College of Medicine , Bronx , NY , USA.
Brannan JM; a US Army Medical Research Institute for Infectious Disease (USAMRIID) , Fort Detrick , MD , USA.
Bakken RR; a US Army Medical Research Institute for Infectious Disease (USAMRIID) , Fort Detrick , MD , USA.
Hust M; d Technische Universität Braunschweig, Institut für Biochemie, Biotechnologie und Bioinformatik Braunschweig , Germany.
Thullier P; b Unite de Biotechnologie des Anticorps, Institut de Recherche Biomedicale des Armees [IRBA-CRSSA] , La Tronche , France.
Dye JM; a US Army Medical Research Institute for Infectious Disease (USAMRIID) , Fort Detrick , MD , USA.
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Źródło :
MAbs [MAbs] 2017 May/Jun; Vol. 9 (4), pp. 696-703. Date of Electronic Publication: 2017 Mar 13.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Antibody Specificity*
Antibodies, Viral/*immunology
Marburgvirus/*immunology
Single-Chain Antibodies/*immunology
Animals ; Humans ; Macaca fascicularis
Czasopismo naukowe
Tytuł :
Anticancer kinase inhibitors impair intracellular viral trafficking and exert broad-spectrum antiviral effects.
Autorzy :
Bekerman E
Neveu G
Shulla A
Brannan J
Pu SY
Wang S
Xiao F
Barouch-Bentov R
Bakken RR
Mateo R
Govero J
Nagamine CM
Diamond MS
De Jonghe S
Herdewijn P
Dye JM
Randall G
Einav S
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Źródło :
The Journal of clinical investigation [J Clin Invest] 2017 Apr 03; Vol. 127 (4), pp. 1338-1352. Date of Electronic Publication: 2017 Feb 27.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Antiviral Agents/*pharmacology
Erlotinib Hydrochloride/*pharmacology
Indoles/*pharmacology
Protein Kinase Inhibitors/*pharmacology
Pyrroles/*pharmacology
Adaptor Protein Complex 1/metabolism ; Adaptor Protein Complex 2/metabolism ; Animals ; Cell Line, Tumor ; Dengue/prevention & control ; Dengue/virology ; Dengue Virus/drug effects ; Dengue Virus/metabolism ; Drug Evaluation, Preclinical ; Drug Synergism ; Ebolavirus/drug effects ; Ebolavirus/metabolism ; Female ; Hemorrhagic Fever, Ebola/prevention & control ; Hemorrhagic Fever, Ebola/virology ; Hepacivirus/drug effects ; Hepacivirus/metabolism ; Hepatitis C/prevention & control ; Hepatitis C/virology ; Humans ; Intracellular Signaling Peptides and Proteins/antagonists & inhibitors ; Intracellular Signaling Peptides and Proteins/metabolism ; Male ; Mice, 129 Strain ; Mice, Inbred C57BL ; Protein Transport ; Protein-Serine-Threonine Kinases/antagonists & inhibitors ; Protein-Serine-Threonine Kinases/metabolism ; Sunitinib ; Virus Internalization/drug effects
Czasopismo naukowe
Tytuł :
A "Trojan horse" bispecific-antibody strategy for broad protection against ebolaviruses.
Autorzy :
Wec AZ; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Nyakatura EK; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Herbert AS; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.
Howell KA; Integrated Biotherapeutics Inc., Gaithersburg, MD 20878, USA.
Holtsberg FW; Integrated Biotherapeutics Inc., Gaithersburg, MD 20878, USA.
Bakken RR; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.
Mittler E; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Christin JR; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Shulenin S; Integrated Biotherapeutics Inc., Gaithersburg, MD 20878, USA.
Jangra RK; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Bharrhan S; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Kuehne AI; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.
Bornholdt ZA; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 10550, USA.
Flyak AI; Department of Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, TN 37235, USA.
Saphire EO; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 10550, USA.; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 10550, USA.
Crowe JE Jr; Department of Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, TN 37235, USA. .; Department of Pediatrics, Vanderbilt University, Nashville, TN 37232, USA.; Vanderbilt Vaccine Center, Vanderbilt University, Nashville, TN 37232, USA.
Aman MJ; Integrated Biotherapeutics Inc., Gaithersburg, MD 20878, USA. .
Dye JM; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA. .
Lai JR; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA. .
Chandran K; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. .
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Źródło :
Science (New York, N.Y.) [Science] 2016 Oct 21; Vol. 354 (6310), pp. 350-354. Date of Electronic Publication: 2016 Sep 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Bispecific/*immunology
Antibodies, Neutralizing/*immunology
Antibodies, Viral/*immunology
Carrier Proteins/*immunology
Ebolavirus/*immunology
Hemorrhagic Fever, Ebola/*prevention & control
Membrane Glycoproteins/*immunology
Receptors, Virus/*immunology
Viral Envelope Proteins/*immunology
Animals ; Antibodies, Monoclonal/immunology ; Binding Sites/immunology ; Cell Line, Tumor ; Endosomes/virology ; Hemorrhagic Fever, Ebola/therapy ; Humans ; Immunotherapy/methods ; Intracellular Signaling Peptides and Proteins ; Mice ; Mice, Inbred BALB C ; Virus Internalization
Czasopismo naukowe
Tytuł :
1,5-Iodonaphthyl azide-inactivated V3526 protects against aerosol challenge with virulent venezuelan equine encephalitis virus.
Autorzy :
Gupta P; Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, United States.
Sharma A; Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, United States. Electronic address: .
Spurgers KB; Virology Division, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, United States.
Bakken RR; Virology Division, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, United States.
Eccleston LT; Virology Division, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, United States.
Cohen JW; Virology Division, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, United States.
Honnold SP; Virology Division, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, United States.
Glass PJ; Virology Division, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, United States.
Maheshwari RK; Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, United States.
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Źródło :
Vaccine [Vaccine] 2016 May 27; Vol. 34 (25), pp. 2762-5. Date of Electronic Publication: 2016 Apr 26.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Encephalomyelitis, Venezuelan Equine/*prevention & control
Vaccination/*methods
Viral Vaccines/*immunology
Aerosols ; Animals ; Antibodies, Viral/blood ; Azides/chemistry ; Encephalitis Virus, Venezuelan Equine ; Immunoglobulin G/blood ; Mice ; Neutralization Tests ; Vaccines, Inactivated/administration & dosage ; Vaccines, Inactivated/immunology ; Viral Vaccines/administration & dosage
Czasopismo naukowe
Tytuł :
Bispecific Antibody Affords Complete Post-Exposure Protection of Mice from Both Ebola (Zaire) and Sudan Viruses.
Autorzy :
Frei JC; Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Ave., Bronx, NY 10461.
Nyakatura EK; Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Ave., Bronx, NY 10461.
Zak SE; Virology Division, United States Army Medical Research Institute of Infectious Disease, 1425 Porter Street, Fort Detrick, MD 21702.
Bakken RR; Virology Division, United States Army Medical Research Institute of Infectious Disease, 1425 Porter Street, Fort Detrick, MD 21702.
Chandran K; Department of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Ave., Bronx, NY 10461.
Dye JM; Virology Division, United States Army Medical Research Institute of Infectious Disease, 1425 Porter Street, Fort Detrick, MD 21702.
Lai JR; Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Ave., Bronx, NY 10461.
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Źródło :
Scientific reports [Sci Rep] 2016 Jan 13; Vol. 6, pp. 19193. Date of Electronic Publication: 2016 Jan 13.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Post-Exposure Prophylaxis*
Antibodies, Bispecific/*immunology
Antibodies, Viral/*immunology
Ebolavirus/*immunology
Hemorrhagic Fever, Ebola/*prevention & control
Hemorrhagic Fever, Ebola/*virology
Animals ; Antibodies, Bispecific/chemistry ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/chemistry ; Antibody Affinity/immunology ; Cell Line ; Cross Reactions ; Disease Models, Animal ; Ebolavirus/classification ; Humans ; Mice ; Neutralization Tests ; Protein Binding ; Protein Engineering
Czasopismo naukowe
Tytuł :
Interferon α/β Receptor-Deficient Mice as a Model for Ebola Virus Disease.
Autorzy :
Brannan JM; US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland.
Froude JW; US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland.
Prugar LI; US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland.
Bakken RR; US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland.
Zak SE; US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland.
Daye SP; US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland.
Wilhelmsen CE; US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland.
Dye JM; US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland.
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Źródło :
The Journal of infectious diseases [J Infect Dis] 2015 Oct 01; Vol. 212 Suppl 2, pp. S282-94. Date of Electronic Publication: 2015 May 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Ebolavirus/*pathogenicity
Hemorrhagic Fever, Ebola/*virology
Receptor, Interferon alpha-beta/*deficiency
Virulence/*physiology
Animals ; Antibodies, Viral/immunology ; Cell Line ; Chlorocebus aethiops ; Disease Models, Animal ; Ebola Vaccines/immunology ; Ebolavirus/metabolism ; Glycoproteins/immunology ; Glycoproteins/metabolism ; Mice ; Mice, Inbred C57BL ; Replicon/immunology ; Vaccination/methods ; Vero Cells/virology ; Viral Proteins/immunology ; Viral Proteins/metabolism ; Virulence/immunology
Czasopismo naukowe
Tytuł :
Human Polyclonal Antibodies Produced through DNA Vaccination of Transchromosomal Cattle Provide Mice with Post-Exposure Protection against Lethal Zaire and Sudan Ebolaviruses.
Autorzy :
Bounds CE; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, United States of America.
Kwilas SA; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, United States of America.
Kuehne AI; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, United States of America.
Brannan JM; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, United States of America.
Bakken RR; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, United States of America.
Dye JM; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, United States of America.
Hooper JW; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, United States of America.
Dupuy LC; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, United States of America.
Ellefsen B; Ichor Medical Systems, Inc., San Diego, California, United States of America.
Hannaman D; Ichor Medical Systems, Inc., San Diego, California, United States of America.
Wu H; SAB Biotherapeutics, Sioux Falls, South Dakota, United States of America.
Jiao JA; SAB Biotherapeutics, Sioux Falls, South Dakota, United States of America.
Sullivan EJ; SAB Biotherapeutics, Sioux Falls, South Dakota, United States of America.
Schmaljohn CS; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, United States of America.
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Źródło :
PloS one [PLoS One] 2015 Sep 30; Vol. 10 (9), pp. e0137786. Date of Electronic Publication: 2015 Sep 30 (Print Publication: 2015).
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Post-Exposure Prophylaxis*/methods
Antibodies, Viral/*metabolism
Ebolavirus/*immunology
Hemorrhagic Fever, Ebola/*prevention & control
Vaccines, DNA/*immunology
Animals ; Animals, Genetically Modified ; Antibodies, Neutralizing/immunology ; Cattle/genetics ; Cattle/immunology ; Chromosomes, Artificial, Human/genetics ; Democratic Republic of the Congo ; Ebola Vaccines/immunology ; Female ; Hemorrhagic Fever, Ebola/virology ; Humans ; Mice ; Mice, Inbred BALB C ; Mice, Knockout ; Receptor, Interferon alpha-beta/genetics ; Sudan ; Vaccination/methods
Czasopismo naukowe
Tytuł :
Eastern equine encephalitis virus in mice II: pathogenesis is dependent on route of exposure.
Autorzy :
Honnold SP; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, 21702, USA. .; Department of Pathology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD, 20814, USA. .
Mossel EC; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, 21702, USA. .
Bakken RR; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, 21702, USA. Russell.r.bakken..
Lind CM; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, 21702, USA. .
Cohen JW; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, 21702, USA. .
Eccleston LT; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, 21702, USA. .
Spurgers KB; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, 21702, USA. .
Erwin-Cohen R; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, 21702, USA. Rebecca.a.erwin-cohen..
Glass PJ; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, 21702, USA. pamela.j.glass..
Maheshwari RK; Department of Pathology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD, 20814, USA. .
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Źródło :
Virology journal [Virol J] 2015 Sep 30; Vol. 12, pp. 154. Date of Electronic Publication: 2015 Sep 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Models, Animal*
Alphavirus Infections/*pathology
Alphavirus Infections/*virology
Encephalitis Virus, Eastern Equine/*growth & development
Encephalitis Virus, Eastern Equine/*physiology
Administration, Inhalation ; Administration, Intranasal ; Animal Structures/pathology ; Animal Structures/virology ; Animals ; Female ; Histocytochemistry ; Immunohistochemistry ; Injections, Subcutaneous ; Mice ; Mice, Inbred BALB C ; Microscopy
Czasopismo naukowe
Tytuł :
Eastern equine encephalitis virus in mice I: clinical course and outcome are dependent on route of exposure.
Autorzy :
Honnold SP; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, 21702, USA. .; Integrated Toxicology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, 21702, USA. .; Present address: Department of Internal Medicine, Center for Global Health, University of New Mexico, Albuquerque, NM, 87131, USA. .
Mossel EC; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, 21702, USA. .
Bakken RR; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, 21702, USA. Russell.r.bakken..
Fisher D; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, 21702, USA. .
Lind CM; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, 21702, USA. .
Cohen JW; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, 21702, USA. .
Eccleston LT; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, 21702, USA. .
Spurgers KB; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, 21702, USA. .
Erwin-Cohen R; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, 21702, USA. Rebecca.a.erwin-cohen..
Bradfute SB; Integrated Toxicology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, 21702, USA. .; Present address: Department of Internal Medicine, Center for Global Health, University of New Mexico, Albuquerque, NM, 87131, USA. .
Maheshwari RK; Department of Pathology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD, 20814, USA. .
Glass PJ; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, 21702, USA. pamela.j.glass..
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Źródło :
Virology journal [Virol J] 2015 Sep 29; Vol. 12, pp. 152. Date of Electronic Publication: 2015 Sep 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Models, Animal*
Alphavirus Infections/*pathology
Encephalitis Virus, Eastern Equine/*growth & development
Encephalitis Virus, Eastern Equine/*pathogenicity
Administration, Inhalation ; Administration, Intranasal ; Alphavirus Infections/virology ; Animal Structures/pathology ; Animal Structures/virology ; Animals ; Body Fluids/virology ; Cytokines/analysis ; Female ; Injections, Subcutaneous ; Mice, Inbred BALB C ; Survival Analysis ; Viral Load
Czasopismo naukowe
Tytuł :
Combined alphavirus replicon particle vaccine induces durable and cross-protective immune responses against equine encephalitis viruses.
Autorzy :
Reed DS; Center for Aerobiological Sciences, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA .
Glass PJ; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA.
Bakken RR; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA.
Barth JF; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA.
Lind CM; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA.
da Silva L; Center for Aerobiological Sciences, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA.
Hart MK; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA.
Rayner J; AlphaVax, Inc., Research Triangle Park, North Carolina, USA.
Alterson K; AlphaVax, Inc., Research Triangle Park, North Carolina, USA.
Custer M; AlphaVax, Inc., Research Triangle Park, North Carolina, USA.
Dudek J; AlphaVax, Inc., Research Triangle Park, North Carolina, USA.
Owens G; AlphaVax, Inc., Research Triangle Park, North Carolina, USA.
Kamrud KI; AlphaVax, Inc., Research Triangle Park, North Carolina, USA.
Parker MD; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA.
Smith J; AlphaVax, Inc., Research Triangle Park, North Carolina, USA.
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Źródło :
Journal of virology [J Virol] 2014 Oct; Vol. 88 (20), pp. 12077-86. Date of Electronic Publication: 2014 Aug 13.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Replicon*
Alphavirus/*immunology
Antibodies, Neutralizing/*immunology
Encephalitis Virus, Eastern Equine/*immunology
Viral Vaccines/*immunology
Alphavirus/classification ; Animals ; Blotting, Western ; Chlorocebus aethiops ; Cricetinae ; Encephalitis Virus, Eastern Equine/classification ; Enzyme-Linked Immunosorbent Assay ; Female ; Fluorescent Antibody Technique ; Macaca fascicularis ; Male ; Mice ; Vero Cells
Czasopismo naukowe
Tytuł :
Second generation inactivated eastern equine encephalitis virus vaccine candidates protect mice against a lethal aerosol challenge.
Autorzy :
Honnold SP; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, United States of America; Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States of America.
Bakken RR; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, United States of America.
Fisher D; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, United States of America.
Lind CM; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, United States of America.
Cohen JW; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, United States of America.
Eccleston LT; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, United States of America.
Spurgers KB; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, United States of America.
Maheshwari RK; Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States of America.
Glass PJ; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, United States of America.
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Źródło :
PloS one [PLoS One] 2014 Aug 12; Vol. 9 (8), pp. e104708. Date of Electronic Publication: 2014 Aug 12 (Print Publication: 2014).
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Antibodies, Neutralizing/*immunology
Antibodies, Viral/*immunology
Encephalitis Virus, Eastern Equine/*immunology
Encephalomyelitis, Equine/*immunology
Viral Vaccines/*immunology
Animals ; Azides/chemistry ; Encephalitis Virus, Eastern Equine/classification ; Encephalomyelitis, Equine/prevention & control ; Female ; Formaldehyde/chemistry ; Gamma Rays ; Immunity, Mucosal/immunology ; Mice ; Mice, Inbred BALB C ; Vaccination ; Vaccines, Attenuated/immunology
Czasopismo naukowe

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